No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
57 |
4. Check minimum number of eventsNone |
57 |
5. Include endpointsNone |
57 |
6. Filter based on genotype QC (FinnGen only) |
57 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Drug-induced acute pancreatitis
based on the number of shared cases.
Similar with more cases:
- Acute pancreatitis (for exclusion)
- Acute pancreatitis
- Disorders of gallbladder, biliary tract and pancreas
- Gastrointestinal diseases
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 273 | 132 | 141 |
| Only index persons | 265 | 130 | 135 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.00 | 0.00 | 0.00 |
| Only index persons | 0.00 | 0.00 | 0.01 |
| Median age at first event (years) | |||
| Whole population | - | 50.38 | 50.23 |
| Only index persons | 50.98 | 50.75 | 51.19 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 57 | 30 | 27 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 47.14 | 50.82 | 43.06 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 50
- Matched controls
- 502
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K85.3
ICD-10 Finland
Drug-induced acute pancreatitis
+∞
71.5
50
*
K85.9
ICD-10 Finland
Acute pancreatitis, unspecified
125.1
16.8
17
*
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
26.7
14.5
20
12
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
15.3
11.3
19
19
L04AX01
ATC
azathioprine; systemic
17.4
10.3
16
13
A07EA06
ATC
budesonide; oral, local oral
20.9
9.7
14
9
JN3AD
NOMESCO Finland
Abdominal CT examination
20.9
9.7
14
9
K50.8
ICD-10 Finland
Other Crohn disease
61.1
9.0
10
*
A07EC02
ATC
mesalazine; oral, rectal
13.7
8.8
15
15
GD1AA
NOMESCO Finland
Thorax X-ray examination
6.3
8.6
33
118
L01BB02
ATC
mercaptopurine; oral
53.7
8.0
9
*
K85.0
ICD-10 Finland
Idiopathic acute pancreatitis
93.4
7.6
8
*
K85.8
ICD-10 Finland
Other acute pancreatitis
93.4
7.6
8
*
H02AB06
ATC
prednisolone; systemic
5.2
7.2
33
135
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
5.7
6.6
21
56
K51.5
ICD-10 Finland
Left sided colitis
15.2
6.4
10
8
UJF32
NOMESCO Finland
Coloscopy
5.2
6.1
21
61
Mortality – FinRegistry
↥Association
Association between endpoint DRUGADVERS_ACUTE_PANCREATIT and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have DRUGADVERS_ACUTE_PANCREATIT.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: DRUGADVERS_ACUTE_PANCREATIT – Drug-induced acute pancreatitis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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