Drug-induced acute pancreatitis

DRUGADVERS_ACUTE_PANCREATIT

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — K85.3# 1 out of 7 registries used, show all original rules.	57
4. Check minimum number of events None	57
5. Include endpoints None	57
6. Filter based on genotype QC (FinnGen only)	57

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: C
First used in FinnGen datafreeze: DF5

NAME	DRUGADVERS_ACUTE_PANCREATIT
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	K853
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Drug-induced acute pancreatitis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	273	132	141
Only index persons	265	130	135
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.01
Median age at first event (years)
Whole population	-	50.38	50.23
Only index persons	50.98	50.75	51.19

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	57	30	27
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	47.14	50.82	43.06

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
50: Matched controls
502

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

K85.3

ICD-10 Finland

Drug-induced acute pancreatitis

+∞

71.5

K85.9

ICD-10 Finland

Acute pancreatitis, unspecified

125.1

16.8

208

Kela drug reimbursment

Ulcerative colitis and Crohn's disease

26.7

14.5

JN1AE

NOMESCO Finland

Ultrasound examination of upper part of abdomen

15.3

11.3

L04AX01

ATC

azathioprine; systemic

17.4

10.3

JN3AD

NOMESCO Finland

Abdominal CT examination

20.9

9.7

A07EA06

ATC

budesonide; oral, local oral

20.9

9.7

K50.8

ICD-10 Finland

Other Crohn disease

61.1

9.0

A07EC02

ATC

mesalazine; oral, rectal

13.7

8.8

GD1AA

NOMESCO Finland

Thorax X-ray examination

6.3

8.6

118

L01BB02

ATC

mercaptopurine; oral

53.7

8.0

K85.0

ICD-10 Finland

Idiopathic acute pancreatitis

93.4

7.6

K85.8

ICD-10 Finland

Other acute pancreatitis

93.4

7.6

H02AB06

ATC

prednisolone; systemic

5.2

7.2

135

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

5.7

6.6

K51.5

ICD-10 Finland

Left sided colitis

15.2

6.4

UJF32

NOMESCO Finland

Coloscopy

5.2

6.1

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3023368) Bacteria identified in Blood by Culture

13.27

21.98

6.8

4.5

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

15.68

19.35

2.1

1.5

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

168

12.71

15.23

13.4

4.0

34.2

36.6

g/l

1.66

159

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

7.89

12.51

6.5

2.3

93.7

28.6

u/l

2.54

(3022145) Colonoscopy Study observation

8.11

12.50

2.1

1.4

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

224

10.99

12.19

24.4

5.9

14.0

11.1

umol/l

0.55

213

(42870588) Differential panel, method unspecified - Blood

164

7.60

11.58

23.2

6.3

—

(3018418) pH of Serum or Plasma

111

6.58

11.52

8.3

3.8

7.4

—

(3001604) Monocytes [#/volume] in Blood

240

9.79

10.95

25.1

6.7

0.6

e9/l

1.17

211

(3006315) Basophils [#/volume] in Blood

241

9.72

10.89

25.1

6.7

0.0

e9/l

0.58

211

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

156

6.24

10.09

10.7

3.3

49.6

27.8

u/l

0.97

144

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

181

6.60

9.86

19.4

6.2

1.2

mmol/l

0.75

159

(3019198) Lymphocytes [#/volume] in Blood

248

7.93

9.48

25.8

6.7

2.1

2.0

e9/l

0.28

221

(3013115) Eosinophils [#/volume] in Blood

248

7.93

9.48

28.7

6.8

0.2

e9/l

1.37

221

(3030467) Casts [#/volume] in Urine by Automated count

114

5.50

9.46

4.7

2.3

0.2

0.3

e6/l

0.55

(3026782) Osmolality of Urine

5.40

8.77

2.5

2.2

502.8

600.2

mosm/kgh2o

1.25

(3002582) Erythrocytes [#/volume] in Urine

121

5.10

8.63

4.5

2.3

20.3

11.5

e6/l

0.46

(3018095) Leukocytes [#/volume] in Urine

149

5.23

8.59

6.4

2.9

47.6

38.4

e6/l

0.12

102

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

8.13

8.47

1.2

1.3

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

5.75

8.36

1.5

1.7

—

(3033658) Prothrombin time (PT) actual/Normal

104

4.98

8.36

16.3

3.7

97.5

94.5

0.25

104

(36304419) Bacteria [Presence] in Urine

112

4.88

8.16

4.6

2.3

—

(3032080) INR in Blood by Coagulation assay

136

4.72

7.77

6.6

6.2

1.1

1.2

inr

—

(3017181) Myelocytes/100 leukocytes in Blood

6.43

7.67

4.3

4.0

1.8

0.4

—

(3046279) Procalcitonin [Mass/volume] in Serum or Plasma

9.12

7.36

1.5

1.8

4.3

19.4

ug/l

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

137

4.35

7.00

4.8

2.6

—

(3037467) Urinalysis macro (dipstick) panel - Urine

305

6.19

6.71

6.4

3.8

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

4.33

6.56

1.7

—

(4035726)

5.66

6.39

1.5

1.3

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

4.45

6.38

4.6

2.3

1.2

0.9

e6/l

0.20

(3021440) Promyelocytes/100 leukocytes in Blood

5.51

5.85

4.5

4.1

0.2

0.0

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

110

3.76

5.63

1.7

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

4.34

5.20

6.7

1.8

349.2

381.5

nmol/l

0.27

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

201

3.67

5.19

5.7

3.2

—

(3021589) Normoblasts [#/volume] in Blood

210

3.71

5.18

31.2

8.3

0.0

e9/l

0.00

167

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

3.85

4.81

3.4

2.7

243.8

1909.9

ng/l

0.47

(3035350) Ketones [Presence] in Urine by Test strip

210

3.43

4.67

7.1

2.9

0.0

estimate

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

3.83

4.59

5.2

2.4

2.9

e6/l

—

(3044640) Blood type and Crossmatch panel - Blood

130

3.27

4.58

6.5

1.9

—

(3021601) Nitrite [Presence] in Urine by Test strip

206

3.27

4.40

10.1

4.1

0.0

estimate

0.00

(3026008) Bacteria identified in Urine by Culture

3.35

4.39

5.3

2.5

—

(3009261) Glucose [Presence] in Urine by Test strip

207

3.24

4.35

7.3

2.9

0.0

estimate

0.00

(3000991) Gas panel - Venous blood

4.26

4.34

8.8

3.9

—

(40758558) Short blood count panel - Blood

126

3.17

4.33

20.1

8.6

—

(3037522) Nuclear Ab [Titer] in Serum

3.46

4.26

1.7

1.4

240.0

483.1

titre

—

(3015736) pH of Urine

176

3.08

4.16

5.1

2.6

—

(3000494) Fungus identified in Specimen by Culture

3.80

3.97

1.7

1.6

—

(3020630) Protein [Mass/volume] in Serum or Plasma

4.64

3.88

4.0

65.5

66.8

g/l

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

4.08

3.86

38.1

3.9

1.1

1.6

mmol/l

1.11

(3034770) Mitochondria Ab [Titer] in Serum

7.54

3.82

1.4

1.3

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

6.45

3.48

1.4

1.0

—

(3042936) Bacteria identified in Isolate by Culture

3.39

3.37

2.9

1.9

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

103

2.85

3.37

6.0

2.9

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

9.39

3.34

3.3

1.7

—

(3002256) Pathology report gross observation

3.45

3.28

1.2

1.1

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

8.21

3.13

1.3

1.0

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

8.21

3.13

1.3

1.0

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

100

2.74

3.08

6.1

1.9

—

(3007853) Bacteria identified in Skin by Aerobe culture

3.35

2.96

2.4

2.0

—

(3003694) ABO and Rh group [Type] in Blood

134

2.54

2.87

1.6

1.4

—

(3021447) Carbon dioxide [Partial pressure] in Venous blood

3.27

2.85

37.4

2.1

5.5

5.7

kpa

0.21

(3025941) Bacteria identified in Stool by Culture

4.25

2.81

1.4

1.2

—

(40760892) CBC W Ordered Manual Differential panel - Blood

112

2.57

2.80

14.7

4.4

—

(3012544) pH of Venous blood

3.19

2.75

37.3

2.2

—

(3035637) Corticotropin [Mass/volume] in Plasma

7.68

2.60

1.8

2.1

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

4.54

2.44

1.0

1.5

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

6.71

2.42

1.2

1.1

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

6.71

2.42

1.0

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

6.71

2.42

1.2

1.1

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

6.71

2.42

1.0

1.4

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

509

+∞

2.42

51.2

11.7

75.3

73.4

umol/l

0.18

509

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

508

+∞

2.41

41.8

9.3

39.0

27.6

u/l

1.32

494

(3002173) Hemoglobin [Mass/volume] in Arterial blood

3.49

2.34

9.0

7.3

128.8

124.3

g/l

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

4.28

2.33

15.0

3.7

105.7

93.3

—

(3023420) DNA double strand Ab [Units/volume] in Serum

5.96

2.26

1.0

1.4

—

(3019060) Gas panel - Arterial blood

4.05

2.23

2.3

6.1

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

139

2.26

2.22

4.9

2.9

19.2

27.7

ng/l

0.36

(3015171) Extractable nuclear Ab [Units/volume] in Serum

4.65

2.21

1.3

1.1

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

4.65

2.21

17.8

4.2

2.8

3.8

g/l

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.86

2.16

2.3

1.5

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

3.14

2.11

4.6

3.0

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.53

2.09

2.4

1.8

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

160

2.15

2.05

6.8

2.7

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

3.65

2.04

61.4

2.0

21.9

25.0

mmol/l

—

(3041096) Erythrocytes [Presence] in Urine by Automated

111

2.24

2.02

6.5

2.5

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.72

1.99

2.5

1.5

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

4.86

1.98

1.0

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

120

2.19

1.98

3.0

2.0

118.0

180.3

u/l

0.63

114

(40768797) Stomach Pathology biopsy report

2.60

1.97

1.2

—

(3014007) Fractional oxyhemoglobin in Arterial blood

3.48

1.95

11.3

8.3

93.4

94.6

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

3.81

1.89

16.8

4.0

161.2

165.6

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

4.45

1.86

1.0

1.3

—

(3029937) Albumin [Presence] in Urine by Test strip

107

2.16

1.84

7.8

2.9

0.0

estimate

—

(40761536) Microorganisms panel - Urine sediment

2.77

1.83

3.8

3.1

—

(40761535) Cells panel - Urine sediment

2.93

1.80

3.0

2.2

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

133

2.07

1.77

1.8

2.2

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

3.04

1.71

58.7

2.1

117.6

131.0

g/l

—

(3003327) Ova and parasites identified in Stool by Light microscopy

3.23

1.63

1.7

1.5

—

(3036489) Thrombin time

3.23

1.63

17.2

3.3

22.2

20.6

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

446

2.89

1.62

31.2

9.6

92.8

91.0

ml/min/173m2

0.22

350

(3008898) HLA-B27 [Presence]

2.65

1.61

1.0

—

(40768804) Tissue Pathology biopsy report

172

1.94

1.60

2.5

1.8

—

(3019225) pH of Specimen

2.81

1.57

2.9

7.4

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

3.55

1.55

1.2

1.5

0.4

0.2

g/l

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

3.07

1.55

1.5

1.8

—

(3007164) IgA [Mass/volume] in Serum or Plasma

122

1.98

1.54

1.7

1.6

1.4

2.6

g/l

4.41

(3044889) 12 lead EKG panel

288

1.96

1.54

3.9

3.2

—

(40768443) Skin Pathology biopsy report

3.12

1.39

1.2

1.1

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

3.12

1.39

1.2

1.5

1.3

1.2

g/l

—

(3022313) Gas panel - Capillary blood

2.67

1.34

4.7

3.7

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

2.02

1.31

1.1

1.2

3.1

u/ml

—

(1761868) Lipid panel - Serum or Plasma

205

0.53

1.18

2.1

2.3

—

(3024354) Oxygen [Partial pressure] in Venous blood

2.16

1.17

53.6

1.9

4.8

5.3

kpa

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

2.51

1.11

3.6

2.2

25.3

24.0

mmol/l

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

2.39

1.05

81.6

1.9

0.7

0.8

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.19

0.92

80.8

3.7

24.0

24.7

mmol/l

—

(3000492) Spirometry study

2.00

0.92

2.0

1.4

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

153

1.59

0.83

3.5

1.8

85.5

95.1

pmol/l

0.82

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

1.71

0.80

1.5

1.3

7.9

30.3

iu/ml

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.28

0.78

81.6

1.9

1.8

1.6

—

(36660697) Celiac disease serology panel - Serum

1.66

0.64

1.5

1.2

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

1.60

0.54

2.8

2.3

1.5

—

(3027450) Sjogrens syndrome-B extractable nuclear Ab [Units/volume] in Serum

0.00

0.42

0.0

1.4

—

(4010399)

1.51

0.41

1.4

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.41

0.0

1.4

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

0.40

0.0

1.1

—

(3013512) EKG study

1.41

0.40

5.1

3.5

—

(21494755) Public health laboratory ask at order entry panel

1.40

0.33

1.5

1.4

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.33

0.29

1.8

2.4

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

0.00

0.21

0.0

1.4

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.21

0.0

1.1

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.4

—

(40768793) Breast Pathology biopsy report

0.00

0.21

0.0

1.2

—

(4094501)

0.00

0.21

0.0

1.2

—

(3025245) SCL-70 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.20

0.0

1.3

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.20

0.0

1.6

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.20

0.0

1.3

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

130

0.81

0.18

1.5

1.6

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

390

1.18

0.16

3.2

3.5

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.10

0.07

1.7

2.2

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.10

0.07

1.0

1.6

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.06

0.07

1.6

1.3

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(4027681)

0.00

0.0

1.2

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.01

0.00

1.7

1.8

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.0

1.3

—

13.1

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

0.00

0.0

1.5

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.6

—

115.9

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

14.0

—

769.4

—

(4146454)

0.00

0.0

2.9

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(3015183) Erythrocyte sedimentation rate

0.00

0.0

1.2

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

15.4

—

1184.0

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.02

0.00

1.6

2.2

—

(3011985) Renin [Units/volume] in Plasma

0.00

0.0

1.1

—

33.0

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.0

1.2

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.7

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.00

0.00

24.8

7.0

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.0

1.2

—

(3005082) Progesterone [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

34.1

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.0

1.4

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.3

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

1.00

0.00

3.0

3.9

34.8

30.3

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

0.00

0.0

1.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint DRUGADVERS_ACUTE_PANCREATIT and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have DRUGADVERS_ACUTE_PANCREATIT.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: DRUGADVERS_ACUTE_PANCREATIT – Drug-induced acute pancreatitis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Drug-induced acute pancreatitis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints