Drug-induced aplastic anaemia

DRUGADVERS_APLAST_ANAEM

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D61.1# 1 out of 7 registries used, show all original rules.	59
4. Check minimum number of events None	59
5. Include endpoints None	59
6. Filter based on genotype QC (FinnGen only)	54

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: C
First used in FinnGen datafreeze: DF5

NAME	DRUGADVERS_APLAST_ANAEM
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D611
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Drug-induced aplastic anaemia based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	549	296	245
Only index persons	425	235	190
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	69.55	71.11	67.73
Only index persons	68.94	70.57	66.92

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	54	27	27
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	65.48	62.67	68.30

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
59: Matched controls
590

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

D61.1

ICD-10 Finland

Drug-induced aplastic anaemia

+∞

84.6

A04AA01

ATC

ondansetron; systemic, rectal

16.3

13.9

D70.82

ICD-10 Finland

Drug-induced neutropenia

59.9

12.5

D64.9

ICD-10 Finland

Anaemia, unspecified

7.8

11.9

A03FA01

ATC

metoclopramide; systemic, rectal

6.6

11.9

WW500

NOMESCO Finland

Blood transfusion

15.2

9.8

H02AB02

ATC

dexamethasone; systemic

6.2

9.2

N02AA05

ATC

oxycodone; systemic

5.4

8.9

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

5.9

8.1

L04AX01

ATC

azathioprine; systemic

22.0

7.9

Z51.5

ICD-10 Finland

Palliative care

8.4

6.9

WD125

NOMESCO Finland

Demanding cystostatic therapy of methastized malignancy

10.1

6.8

Z51.1

ICD-10 Finland

Chemotherapy session for neoplasm

77.9

6.6

D70.89

ICD-10 Finland

Neutropenic splenomegaly

30.3

6.4

L03AA02

ATC

filgrastim; parenteral

14.7

6.3

WD105

NOMESCO Finland

Cystostatic therapy of methastized malignancy

11.0

6.1

R50.9

ICD-10 Finland

Fever, unspecified

4.2

6.1

GD1AA

NOMESCO Finland

Thorax X-ray examination

3.9

6.1

178

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3018418) pH of Serum or Plasma

139

4.41

7.39

8.0

5.0

7.40

7.41

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

14.70

6.34

1.5

1.3

—

(40760892) CBC W Ordered Manual Differential panel - Blood

200

4.11

6.24

21.9

7.3

—

(3023368) Bacteria identified in Blood by Culture

110

3.94

6.22

7.2

4.6

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

17.33

6.12

1.3

1.2

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

13.06

6.05

1.5

1.3

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

4.54

6.02

1.9

1.8

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

5.87

5.72

2.1

1.7

—

(40758558) Short blood count panel - Blood

114

3.52

5.23

25.4

6.2

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

4.10

5.09

2.2

1.9

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

4.10

5.09

2.1

1.9

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

10.05

4.43

2.8

2.1

—

(3043849) Epstein Barr virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

12.99

4.39

3.1

1.3

—

u/ml

—

(3044640) Blood type and Crossmatch panel - Blood

140

3.11

4.36

8.1

2.1

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

7.94

4.34

1.4

1.6

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

7.94

4.34

1.4

1.6

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

3.21

4.26

10.8

2.1

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

3.31

4.04

2.4

2.0

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

8.20

4.00

1.5

—

(4035726) Immunohistochemistry procedure

4.26

3.95

1.3

1.4

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

6.42

3.83

1.6

1.3

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

210

2.83

3.66

9.8

2.3

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

3.05

3.65

2.3

2.0

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

222

2.79

3.52

10.8

6.3

1.21

mmol/l

0.10

185

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

4.26

3.29

1.9

1.5

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

2.81

3.27

4.8

4.0

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

2.96

3.16

1.9

1.7

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

2.88

3.13

4.1

2.2

0.73

1.06

e6/l

0.34

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

8.18

3.13

1.3

1.5

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

8.18

3.13

1.7

1.6

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

8.18

3.13

1.3

1.5

—

(3000012) Reticulocyte production index

10.75

3.03

2.8

2.0

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

3.01

2.99

2.9

2.7

1.82

2.31

g/l

2.40

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

5.94

2.96

1.3

2.2

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

7.26

2.94

1.5

1.4

—

(40763324) Parainfluenza virus 1 RNA [Presence] in Isolate by NAA with probe detection

8.95

2.80

1.4

1.7

—

(40763470) Parainfluenza virus 4 RNA [Presence] in Isolate by NAA with probe detection

8.95

2.80

1.4

1.7

—

(40768804) Tissue Pathology biopsy report

160

2.43

2.76

1.5

2.1

—

(3022145) Colonoscopy Study observation

3.17

2.74

1.5

1.3

—

(3000991) Gas panel - Venous blood

3.42

2.66

8.9

3.6

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

2.54

2.66

1.9

1.7

1.74

1.14

mg/l

0.55

(3022217) INR in Platelet poor plasma by Coagulation assay

224

2.38

2.65

5.5

12.7

1.02

1.19

inr

2.50

(3030905) Polymorphonuclear cells [#/volume] in Blood

5.93

2.61

8.8

2.5

3.95

5.61

e9/l

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

5.93

2.61

10.8

2.5

55.67

61.64

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

7.66

2.60

1.4

1.7

—

(36304419) Bacteria [Presence] in Urine

131

2.40

2.59

4.0

2.8

—

(3022948) Iron [Moles/volume] in Serum or Plasma

2.75

2.57

3.5

2.6

20.27

13.57

umol/l

0.78

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

4.23

2.57

2.5

2.1

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

175

2.29

2.47

5.3

2.9

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

2.81

2.40

3.2

2.9

44.47

24.75

0.95

(3018095) Leukocytes [#/volume] in Urine

171

2.21

2.27

4.8

3.6

47.90

42.02

e6/l

0.08

122

(3004588) Protein electrophoresis panel - Serum or Plasma

3.13

2.27

1.6

2.7

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

5.95

2.26

1.6

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

5.95

2.26

3.8

1.6

4.02

2.50

u/ml

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

2.49

2.15

4.6

2.3

1.76

2.50

e6/l

—

(3021601) Nitrite [Presence] in Urine by Test strip

231

2.11

2.05

7.2

4.8

0.00

estimate

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

2.64

2.03

12.6

4.0

104.58

103.69

mmol/l

0.28

(3009261) Glucose [Presence] in Urine by Test strip

233

2.08

1.98

6.0

3.6

0.00

estimate

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

4.85

1.98

1.6

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

4.44

1.86

1.6

1.7

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

2.76

1.83

8.1

2.8

1.02

1.22

mmol/l

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

175

2.00

1.78

2.5

2.1

84.52

95.08

pmol/l

0.57

(3035350) Ketones [Presence] in Urine by Test strip

230

1.99

1.77

6.2

3.6

0.00

estimate

—

(3052851) Hemolysis interference index of Serum or Plasma

4.10

1.75

4.4

4.3

—

(3007164) IgA [Mass/volume] in Serum or Plasma

2.18

1.71

1.8

1.5

2.35

2.25

g/l

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

3.80

1.65

6.2

5.4

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

3.22

1.62

2.3

1.9

—

(40768797) Stomach Pathology biopsy report

2.21

1.52

1.1

1.2

—

(3000494) Fungus identified in Specimen by Culture

2.41

1.49

1.1

1.3

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.92

1.47

2.3

2.2

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.92

1.47

16.0

5.4

23.58

23.97

mmol/l

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.78

1.40

1.8

1.6

—

(4200892) Spirometry reversibility

0.00

1.39

0.0

1.3

—

(3016502) Oxygen saturation in Arterial blood

2.29

1.37

5.9

3.1

96.68

94.75

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

197

1.80

1.36

4.0

44.41

34.72

ng/l

0.20

138

(3037467) Urinalysis macro (dipstick) panel - Urine

324

1.87

1.36

5.7

4.2

—

(3025941) Bacteria identified in Stool by Culture

2.66

1.34

1.0

1.2

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.23

1.34

6.6

4.4

—

(3020891) Body temperature

2.55

1.28

5.3

3.5

—

(3002173) Hemoglobin [Mass/volume] in Arterial blood

2.34

1.27

6.5

3.2

108.25

124.51

g/l

—

(3045414) Leukocytes [Presence] in Urine

2.78

1.24

2.2

1.4

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

2.45

1.22

7.5

2.7

0.73

0.76

—

(3042936) Bacteria identified in Isolate by Culture

2.10

1.21

1.6

2.0

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

1.94

1.14

4.5

4.4

12226.54

91.08

ng/l

0.51

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

178

1.70

1.12

3.0

2.4

67.56

75.75

nmol/l

0.90

156

(3003694) ABO and Rh group [Type] in Blood

125

1.77

1.12

1.9

1.4

—

(3000963) Hemoglobin [Mass/volume] in Blood

505

0.54

1.06

67.6

21.3

117.87

135.48

g/l

5.88

494

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

1.94

1.02

6.0

3.0

4.84

5.00

kpa

—

(3027801) Oxygen [Partial pressure] in Arterial blood

1.94

1.02

5.9

3.0

12.17

12.40

kpa

—

(3009542) Hematocrit [Volume Fraction] of Blood

504

0.55

1.02

67.6

21.0

35.59

40.37

5.26

472

(3035941) MCH [Entitic mass]

504

0.55

1.02

67.2

21.1

31.12

30.44

1.83

493

(3024731) MCV [Entitic volume]

504

0.55

1.02

67.2

21.1

93.98

91.32

2.66

493

(3048689) Calprotectin [Mass/mass] in Stool

1.99

0.99

7.9

1.3

616.60

190.44

ug/g

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

2.36

0.96

7.5

2.7

1.55

1.77

—

(36660697) Celiac disease serology panel - Serum

2.27

0.94

1.2

1.1

—

(40761535) Cells panel - Urine sediment

2.04

0.93

6.8

2.5

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

2.19

0.92

3.2

2.6

50.80

50.25

—

(3022621) pH of Urine by Test strip

1.91

0.81

2.2

2.8

—

(40761511) CBC panel - Blood by Automated count

470

0.63

0.75

29.3

13.5

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.67

0.68

1.3

1.6

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.86

0.68

6.8

2.5

0.80

0.74

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.79

0.65

6.8

2.5

1.22

1.48

—

(3019150) Specific gravity of Urine by Refractometry

107

1.54

0.63

6.0

3.4

—

1.01

—

(3029937) Albumin [Presence] in Urine by Test strip

134

1.49

0.63

8.3

3.7

0.00

estimate

—

(1002224) Polysomnography panel

0.00

0.61

0.0

1.1

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.61

0.0

1.4

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.53

0.56

22.3

9.2

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

179

1.37

0.47

7.6

3.6

—

(3002385) Erythrocyte distribution width [Ratio]

389

1.39

0.46

52.0

17.6

16.34

14.98

0.90

382

(3004119) Hemoglobin [Mass/volume] in Venous blood

1.67

0.44

6.8

2.5

117.60

127.65

g/l

—

(3008152) Bicarbonate [Moles/volume] in Arterial blood

1.61

0.43

7.6

4.4

26.28

24.83

mmol/l

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

114

0.66

0.42

1.5

1.6

1.66

1.27

mmol/l

—

(3026008) Bacteria identified in Urine by Culture

144

1.36

0.42

5.4

3.0

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.41

0.0

1.5

—

(3019060) Gas panel - Arterial blood

1.47

0.40

5.6

2.5

—

(1761868) Lipid panel - Serum or Plasma

142

0.72

0.36

3.9

3.2

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.37

0.35

2.0

1.7

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.34

0.32

2.0

1.4

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

476

0.77

0.28

35.2

10.2

26.13

25.18

u/l

0.19

455

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

262

1.21

0.24

4.2

3.2

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

473

0.80

0.23

51.0

17.1

90.69

81.14

umol/l

0.78

473

(3044889) 12 lead EKG panel

323

1.21

0.23

3.9

4.2

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

146

1.23

0.22

3.1

4.1

17.40

23.83

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.21

0.0

1.1

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.21

0.0

1.0

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.21

0.0

1.3

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.1

—

(3006999) Ribonucleoprotein extractable nuclear Ab [Units/volume] in Serum

0.00

0.21

0.0

1.4

—

18.10

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.1

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.21

0.0

1.1

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.1

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.6

—

(3010726) Horse dander IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.0

—

0.08

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.2

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.1

—

(4094501) Cardiovascular stress test using bicycle ergometer

0.00

0.21

0.0

1.1

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.1

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.21

0.0

1.1

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.21

0.0

1.8

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.21

0.0

1.8

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.25

0.21

2.3

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.22

0.20

1.0

1.2

—

(3020682) Albumin/Creatinine [Ratio] in Urine

134

1.16

0.12

3.3

3.8

5.67

9.23

mg/mmol

—

(40761536) Microorganisms panel - Urine sediment

1.15

0.10

9.6

4.0

—

(3041096) Erythrocytes [Presence] in Urine by Automated

134

0.87

0.10

8.1

3.1

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.12

0.09

2.7

2.5

—

(3013512) EKG study

141

0.90

0.06

3.6

4.2

—

(3002256) Pathology report gross observation

0.98

0.00

1.0

1.2

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

-0.00

0.0

1.3

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

-0.00

0.0

1.1

—

(3003434) Protein [Mass/volume] in Pleural fluid

0.00

-0.00

0.0

1.2

—

28.02

—

(40760848) Basement membrane zone BP180 Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.2

—

(40768806) Pleura Pathology biopsy report

0.00

-0.00

0.0

1.1

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

-0.00

0.0

1.6

—

(3036782) Glucose [Moles/volume] in Pleural fluid

0.00

-0.00

0.0

1.0

—

7.63

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

-0.00

0.0

1.3

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

-0.00

0.0

1.3

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.5

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

-0.00

0.0

1.3

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.5

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

12.33

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.3

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

-0.00

0.0

1.7

—

(3005033) Fetal Nuchal fold Thickness US

0.00

-0.00

0.0

1.3

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.5

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.2

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.3

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

-0.00

0.0

1.1

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.1

—

(3012441) Differential panel - Pleural fluid

0.00

-0.00

0.0

1.0

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

3.0

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

-0.00

0.0

1.3

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.5

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.5

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

-0.00

0.0

1.3

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

1.6

—

13.40

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

-0.00

0.0

1.3

—

(4062490) Immunoglobulin typing, IgG

0.00

-0.00

0.0

1.2

—

(3044927) Protein electrophoresis panel - Urine

0.00

-0.00

0.0

1.0

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

-0.00

0.0

1.2

—

(3005570) Glucose [Moles/volume] in Urine

0.00

-0.00

0.0

3.8

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

-0.00

0.0

1.3

—

(3025130) Human papilloma virus identified in Specimen

0.00

-0.00

0.0

2.2

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

0.90

-0.00

1.7

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.5

—

(3019420) Tryptase [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

5.52

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

-0.00

0.0

1.2

—

135.60

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

-0.00

0.0

1.7

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.2

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

-0.00

0.0

1.0

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.1

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.1

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

-0.00

0.0

1.6

—

Mortality – FinRegistry

↥

Association

Association between endpoint DRUGADVERS_APLAST_ANAEM and mortality.

Females

Parameter	HR [95% CI]	p-value
DRUGADVERS_APLAST_ANAEM	4.979 [2.92, 8.49]	< 0.001
Birth year	0.995 [0.99, 1.0]	0.247

During the follow-up period (1.1.1998 — 31.12.2019), 149 out of 248 females with DRUGADVERS_APLAST_ANAEM died.

Males

Parameter	HR [95% CI]	p-value
DRUGADVERS_APLAST_ANAEM	6.784 [3.45, 13.35]	< 0.001
Birth year	0.984 [0.97, 0.99]	0.001

During the follow-up period (1.1.1998 — 31.12.2019), 138 out of 209 males with DRUGADVERS_APLAST_ANAEM died.

Mortality risk

Mortality risk for people of age

years, who have DRUGADVERS_APLAST_ANAEM.

N-year risk	Females	Males
1	0.537%	0.922%
5	3.103%	7.005%
10	7.649%	16.357%
15	14.183%	29.634%
20	22.687%	44.419%

Relationships between endpoints

↥

Index endpoint: DRUGADVERS_APLAST_ANAEM – Drug-induced aplastic anaemia

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Drug-induced aplastic anaemia

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints