This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Drug-induced aplastic anaemia
DRUGADVERS_APLAST_ANAEM
No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
55 |
4. Check minimum number of eventsNone |
55 |
5. Include endpointsNone |
55 |
6. Filter based on genotype QC (FinnGen only) |
55 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Drug-induced aplastic anaemia
based on the number of shared cases.
Similar with more cases:
- Other and unspecified aplastic anaemias
- Aplastic and other anaemias
- Anaemias
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 549 | 296 | 245 |
| Only index persons | 425 | 235 | 190 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 69.55 | 71.11 | 67.73 |
| Only index persons | 68.94 | 70.57 | 66.92 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 55 | 26 | 29 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 64.77 | 60.83 | 68.30 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 52
- Matched controls
- 520
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D61.1
ICD-10 Finland
Drug-induced aplastic anaemia
+∞
74.4
52
*
WW500
NOMESCO Finland
Blood transfusion
33.3
14.1
18
8
D70.82
ICD-10 Finland
Drug-induced neutropenia
152.4
12.0
12
*
A04AA01
ATC
ondansetron; systemic, rectal
15.1
10.2
17
16
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
25.3
9.0
12
6
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
25.3
9.0
12
6
XW000
NOMESCO Finland
Bone marrow biopsy
25.3
9.0
12
6
R50.9
ICD-10 Finland
Fever, unspecified
8.9
8.9
20
34
H02AB02
ATC
dexamethasone; systemic
8.9
8.2
18
29
L03AA02
ATC
filgrastim; parenteral
53.3
8.0
9
*
D64.9
ICD-10 Finland
Anaemia, unspecified
8.0
7.7
18
32
A03FA01
ATC
metoclopramide; systemic, rectal
5.4
6.8
23
66
D70.89
ICD-10 Finland
Neutropenic splenomegaly
79.2
6.6
7
*
Mortality – FinRegistry
↥Association
Association between endpoint DRUGADVERS_APLAST_ANAEM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| DRUGADVERS_APLAST_ANAEM | 4.979 [2.92, 8.49] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.247 |
During the follow-up period (1.1.1998 — 31.12.2019), 149 out of 248 females with DRUGADVERS_APLAST_ANAEM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| DRUGADVERS_APLAST_ANAEM | 6.784 [3.45, 13.35] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 138 out of 209 males with DRUGADVERS_APLAST_ANAEM died.
Mortality risk
Mortality risk for people of age
years, who have DRUGADVERS_APLAST_ANAEM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.537% | 0.922% |
| 5 | 3.103% | 7.005% |
| 10 | 7.649% | 16.357% |
| 15 | 14.183% | 29.634% |
| 20 | 22.687% | 44.419% |
Relationships between endpoints
↥Index endpoint: DRUGADVERS_APLAST_ANAEM – Drug-induced aplastic anaemia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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