Drug-induced aplastic anaemia

DRUGADVERS_APLAST_ANAEM

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D61.1# 1 out of 7 registries used, show all original rules.	55
4. Check minimum number of events None	55
5. Include endpoints None	55
6. Filter based on genotype QC (FinnGen only)	55

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: C
First used in FinnGen datafreeze: DF5

NAME	DRUGADVERS_APLAST_ANAEM
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D611
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Drug-induced aplastic anaemia based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	549	296	245
Only index persons	425	235	190
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	69.55	71.11	67.73
Only index persons	68.94	70.57	66.92

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	55	26	29
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	64.77	60.83	68.30

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
52: Matched controls
520

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

D61.1

ICD-10 Finland

Drug-induced aplastic anaemia

+∞

74.4

WW500

NOMESCO Finland

Blood transfusion

33.3

14.1

D70.82

ICD-10 Finland

Drug-induced neutropenia

152.4

12.0

A04AA01

ATC

ondansetron; systemic, rectal

15.1

10.2

XW000

NOMESCO Finland

Bone marrow biopsy

25.3

9.0

WD125

NOMESCO Finland

Demanding cystostatic therapy of methastized malignancy

25.3

9.0

117

Kela drug reimbursment

Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue

25.3

9.0

R50.9

ICD-10 Finland

Fever, unspecified

8.9

H02AB02

ATC

dexamethasone; systemic

8.9

8.2

L03AA02

ATC

filgrastim; parenteral

53.3

8.0

D64.9

ICD-10 Finland

Anaemia, unspecified

8.0

7.7

A03FA01

ATC

metoclopramide; systemic, rectal

5.4

6.8

D70.89

ICD-10 Finland

Neutropenic splenomegaly

79.2

6.6

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3021879) Hepatitis B virus core Ab [Presence] in Serum

7.26

8.55

1.9

—

(3018418) pH of Serum or Plasma

128

4.26

6.60

8.5

5.1

7.4

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

15.01

5.81

1.3

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

4.60

5.53

2.1

2.0

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

13.13

5.51

1.3

1.4

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

15.73

4.71

1.4

1.2

—

(4035726)

4.42

4.52

1.2

1.3

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

10.15

4.44

2.8

2.1

—

(42870588) Differential panel, method unspecified - Blood

133

3.25

4.41

20.1

5.7

—

(3043849) Epstein Barr virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

13.10

4.40

3.1

1.3

—

u/ml

—

(3023368) Bacteria identified in Blood by Culture

106

3.24

4.24

8.0

4.5

—

(40758558) Short blood count panel - Blood

110

3.10

3.94

26.1

6.2

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

3.29

3.90

2.2

2.1

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

6.99

3.65

1.4

1.6

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

6.99

3.65

1.4

1.6

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

3.57

3.61

1.8

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

11.01

3.58

1.5

1.7

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

4.30

3.53

1.9

1.5

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

3.00

3.53

11.5

2.1

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

3.49

3.50

1.9

1.8

—

(3044640) Blood type and Crossmatch panel - Blood

132

2.84

3.47

8.7

2.1

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

3.23

3.41

1.7

—

(3000991) Gas panel - Venous blood

3.92

3.40

8.9

3.4

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

6.04

3.33

1.6

1.3

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

7.10

3.29

1.4

1.5

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

206

2.70

3.13

11.3

6.3

1.2

mmol/l

0.20

171

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

5.99

2.97

1.3

2.2

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

2.77

2.94

4.9

3.8

—

(44790049)

9.00

2.80

1.4

1.7

—

(44790047)

9.00

2.80

1.4

1.7

—

(44806118)

9.00

2.80

1.4

1.7

—

(44790048)

9.00

2.80

1.4

1.7

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

200

2.43

2.61

17.6

3.9

—

(3012544) pH of Venous blood

3.06

2.56

6.1

2.6

—

(3022948) Iron [Moles/volume] in Serum or Plasma

2.84

2.54

3.6

2.6

20.5

13.4

umol/l

0.77

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

6.73

2.42

1.6

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

2.92

2.37

3.2

3.0

45.8

24.8

0.93

(3004789) Transferrin [Mass/volume] in Serum or Plasma

2.79

2.33

3.0

2.7

1.7

2.3

g/l

2.80

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.57

2.23

2.3

2.0

—

(40768804) Tissue Pathology biopsy report

148

2.26

2.22

1.3

2.0

—

(40760892) CBC W Ordered Manual Differential panel - Blood

2.39

2.17

12.0

6.7

—

(3015736) pH of Urine

160

2.19

2.07

5.8

3.0

—

(3004588) Protein electrophoresis panel - Serum or Plasma

3.06

2.04

1.7

2.8

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

3.06

2.04

8.1

2.8

1.0

1.2

mmol/l

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

4.88

1.98

11.6

2.5

51.2

61.6

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

4.88

1.98

9.4

2.5

2.4

5.6

e9/l

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

164

2.11

1.91

5.7

2.8

—

(3022145) Colonoscopy Study observation

2.76

1.88

1.6

1.3

—

(3014007) Fractional oxyhemoglobin in Arterial blood

3.33

1.87

6.6

2.8

95.1

92.6

—

(3052851) Hemolysis interference index of Serum or Plasma

4.46

1.86

4.4

4.6

—

(36304419) Bacteria [Presence] in Urine

123

2.14

1.86

4.2

2.7

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

2.20

1.77

1.9

1.8

1.2

mg/l

0.01

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

4.11

1.75

6.2

5.4

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

3.41

1.71

2.2

1.9

—

(3018095) Leukocytes [#/volume] in Urine

162

2.00

1.66

5.0

3.5

54.2

44.0

e6/l

0.13

116

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

3.24

1.63

1.8

1.7

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

166

1.93

1.52

2.4

2.1

86.7

94.9

pmol/l

0.40

(3000963) Hemoglobin [Mass/volume] in Blood

475

0.46

1.51

68.3

20.9

118.1

135.5

g/l

5.02

464

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

2.93

1.48

7.5

2.6

0.7

0.8

—

(3024731) MCV [Entitic volume]

474

0.47

1.46

67.9

20.8

93.9

91.3

2.29

463

(3035941) MCH [Entitic mass]

474

0.47

1.46

67.8

20.7

31.2

30.4

1.78

463

(3021601) Nitrite [Presence] in Urine by Test strip

215

1.87

1.43

7.7

4.7

0.0

estimate

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

2.80

1.41

7.5

2.6

1.5

1.9

—

(4010399)

0.00

1.40

0.0

1.2

—

(3009261) Glucose [Presence] in Urine by Test strip

216

1.86

1.40

6.4

3.5

0.0

estimate

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.79

1.24

2.4

2.0

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.79

1.24

2.2

2.3

—

(3035350) Ketones [Presence] in Urine by Test strip

213

1.76

1.22

6.6

3.5

0.0

estimate

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

185

1.77

1.22

3.8

3.9

46.7

33.0

ng/l

0.27

128

(3016502) Oxygen saturation in Arterial blood

2.23

1.21

6.0

3.1

97.3

94.5

—

(3007164) IgA [Mass/volume] in Serum or Plasma

1.95

1.19

1.7

1.4

2.5

2.2

g/l

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.64

1.17

15.2

5.6

23.0

24.2

mmol/l

—

(40761511) CBC panel - Blood by Automated count

443

0.54

1.17

29.6

13.4

—

(3032080) INR in Blood by Coagulation assay

179

1.73

1.13

4.1

6.3

1.0

1.2

inr

—

(40768797) Stomach Pathology biopsy report

2.04

1.12

1.1

1.2

—

(3025941) Bacteria identified in Stool by Culture

2.51

1.11

1.0

1.2

—

(3000494) Fungus identified in Specimen by Culture

2.14

1.10

1.1

1.3

—

(3002173) Hemoglobin [Mass/volume] in Arterial blood

2.28

1.10

6.7

3.2

106.6

125.0

g/l

—

(3042936) Bacteria identified in Isolate by Culture

2.00

1.00

1.6

2.0

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

2.37

0.97

3.2

2.5

50.8

48.9

—

(36660697) Celiac disease serology panel - Serum

2.28

0.95

1.2

1.1

—

(3037467) Urinalysis macro (dipstick) panel - Urine

304

1.66

0.93

5.8

4.2

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

168

1.63

0.93

3.0

2.4

67.7

76.3

nmol/l

0.88

146

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

1.86

0.87

6.0

2.9

4.8

5.0

kpa

—

(3027801) Oxygen [Partial pressure] in Arterial blood

1.86

0.87

5.9

2.9

12.6

12.0

kpa

—

(3020891) Body temperature

2.29

0.78

5.2

3.3

—

(40761535) Cells panel - Urine sediment

1.91

0.76

7.4

2.4

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.81

0.73

1.3

1.7

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.81

0.73

7.4

4.6

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.93

0.70

6.8

2.6

1.2

1.5

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

1.79

0.65

6.8

2.5

117.6

126.7

g/l

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

1.66

0.65

4.4

14448.4

93.7

ng/l

0.50

(3019150) Specific gravity of Urine by Refractometry

1.56

0.62

6.3

3.3

—

1.0

—

(3048689) Calprotectin [Mass/mass] in Stool

1.59

0.62

8.0

1.4

743.1

199.8

ug/g

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.63

0.59

22.3

8.0

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

107

0.60

0.55

1.6

1.7

1.3

mmol/l

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

445

0.69

0.47

35.4

10.1

26.6

25.1

u/l

0.29

424

(3020564) Creatinine [Moles/volume] in Serum or Plasma

444

0.70

0.45

50.9

16.8

91.2

80.3

umol/l

0.85

444

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.42

0.0

1.4

—

(3029937) Albumin [Presence] in Urine by Test strip

126

1.38

0.41

9.1

3.7

0.0

estimate

—

(1002224) Polysomnography panel

0.00

0.40

0.0

1.1

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.40

0.0

1.4

—

(3003694) ABO and Rh group [Type] in Blood

118

1.37

0.39

1.9

1.4

—

(3020682) Albumin/Creatinine [Ratio] in Urine

124

1.29

0.27

3.5

4.1

5.7

9.6

mg/mmol

—

(3041096) Erythrocytes [Presence] in Urine by Automated

124

0.76

0.25

9.4

3.2

—

(3026008) Bacteria identified in Urine by Culture

136

1.25

0.23

5.6

3.0

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.21

0.0

1.3

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.21

0.0

1.9

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.21

0.0

1.1

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.1

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.0

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.1

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.0

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.1

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.1

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.21

0.0

1.1

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.6

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.21

0.0

1.8

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.21

0.0

1.1

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.31

0.21

2.3

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

167

1.21

0.20

8.6

3.6

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.22

0.20

2.0

1.4

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.17

0.20

2.7

2.5

—

(3009542) Hematocrit [Volume Fraction] of Blood

372

0.84

0.19

49.3

14.2

35.1

40.1

1.85

255

(3013512) EKG study

130

0.81

0.18

4.0

4.2

—

(3044889) 12 lead EKG panel

301

1.15

0.14

3.9

4.1

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.15

0.10

2.2

1.7

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

136

1.14

0.10

3.1

4.1

16.9

23.7

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.05

0.09

1.0

1.2

—

(1761868) Lipid panel - Serum or Plasma

123

0.87

0.09

3.9

3.1

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

246

1.03

0.00

4.5

3.0

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.6

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.0

1.3

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.0

1.3

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

12.3

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.3

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.5

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

1.8

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.5

—

(3003434) Protein [Mass/volume] in Pleural fluid

0.00

0.0

1.2

—

28.0

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.5

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.3

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.3

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.0

1.7

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.3

—

(3036782) Glucose [Moles/volume] in Pleural fluid

0.00

0.0

1.0

—

7.6

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.5

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.3

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.4

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.3

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.0

1.3

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.5

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.1

—

(3042631) Mycobacterium sp identified in Specimen

0.00

0.0

7.1

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.5

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.0

1.1

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.0

1.2

—

135.6

—

(3036432) Mycobacterium tuberculosis genotype [Identifier] in Isolate

0.00

0.0

10.4

—

(3019420) Tryptase [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

5.5

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

3.8

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.0

1.4

—

(3020287) Protein C actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.0

—

105.4

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

1.6

—

(4306422)

0.00

0.0

1.0

—

(4094501)

0.00

0.0

1.1

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.0

1.1

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.0

1.1

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

0.97

0.00

1.7

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.0

3.0

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.0

1.6

—

(3020629) Protein S Free Ag actual/normal in Platelet poor plasma by Immunoassay

0.00

0.0

1.0

—

97.4

—

(3017569) Oxygen content in Arterial blood

0.00

0.0

2.6

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.0

2.4

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.0

1.1

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.0

1.2

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.0

1.4

—

(3044927) Protein electrophoresis panel - Urine

0.00

0.0

1.0

—

(40768806) Pleura Pathology biopsy report

0.00

0.0

1.1

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.0

1.0

—

(40760848) Basement membrane zone BP180 Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(3012441) Differential panel - Pleural fluid

0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint DRUGADVERS_APLAST_ANAEM and mortality.

Females

Parameter	HR [95% CI]	p-value
DRUGADVERS_APLAST_ANAEM	4.979 [2.92, 8.49]	< 0.001
Birth year	0.995 [0.99, 1.0]	0.247

During the follow-up period (1.1.1998 — 31.12.2019), 149 out of 248 females with DRUGADVERS_APLAST_ANAEM died.

Males

Parameter	HR [95% CI]	p-value
DRUGADVERS_APLAST_ANAEM	6.784 [3.45, 13.35]	< 0.001
Birth year	0.984 [0.97, 0.99]	0.001

During the follow-up period (1.1.1998 — 31.12.2019), 138 out of 209 males with DRUGADVERS_APLAST_ANAEM died.

Mortality risk

Mortality risk for people of age

years, who have DRUGADVERS_APLAST_ANAEM.

N-year risk	Females	Males
1	0.537%	0.922%
5	3.103%	7.005%
10	7.649%	16.357%
15	14.183%	29.634%
20	22.687%	44.419%

Relationships between endpoints

↥

Index endpoint: DRUGADVERS_APLAST_ANAEM – Drug-induced aplastic anaemia

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Drug-induced aplastic anaemia

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints