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Other and unspecified aplastic anaemias

DOID EFO Endpoint Browser PheWeb

D3_OTHERAPLASTICANAEMIA

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D61
  • Hospital discharge: ICD-9 — 2848
  • Hospital discharge: ICD-8 — 284
  • Hospital discharge: excluded ICD-9 — 2848C
  • Hospital discharge: excluded ICD-8 — 28404
  • Cause of death: ICD-10 — D61
  • Cause of death: ICD-9 — 2848
  • Cause of death: ICD-8 — 284
  • Cause of death: excluded ICD-9 — 2848C
  • Cause of death: excluded ICD-8 — 28404
  • KELA reimbursements: KELA codes — 122

3 out of 7 registries used, show all original rules.

424

4. Check minimum number of events

None

424

5. Include endpoints

None

424

6. Filter based on genotype QC (FinnGen only)

401

Control definitions (FinnGen only)

Control exclude
D3_APLASTICANDOTHANAEMIA

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D60-D64
Name in latin
Aliae anaemia aplasticae

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4109 2037 1985
Only index persons 2722 1371 1351
Unadjusted period prevalence (%)
Whole population 0.06 0.06 0.06
Only index persons 0.05 0.05 0.05
Median age at first event (years)
Whole population 64.32 65.00 63.49
Only index persons 61.52 61.81 61.22

-FinnGen-

Key figures

All Female Male
Number of individuals 401 189 212
Unadjusted period prevalence (%) 0.08 0.07 0.10
Median age at first event (years) 62.00 55.68 67.63

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
424
Matched controls
4240
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D64.9
ICD-10 Finland
Anaemia, unspecified
37.5
253.7
175
78
XW000
NOMESCO Finland
Bone marrow biopsy
41.1
235.5
154
58
D61.9
ICD-10 Finland
Aplastic anaemia, unspecified
+∞
219.4
191
*
L04AD01
ATC
ciclosporin; systemic
69.8
168.0
93
17
WW500
NOMESCO Finland
Blood transfusion
23.0
148.3
118
70
122
Kela drug reimbursment
Aplastic anaemia
+∞
119.6
109
*
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
36.0
119.0
77
26
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
49.5
95.1
56
13
D70.89
ICD-10 Finland
Neutropenic splenomegaly
40.2
85.5
53
15
D61.0
ICD-10 Finland
Constitutional aplastic anaemia
+∞
75.3
70
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
10.8
71.3
85
96
D61.3
ICD-10 Finland
Idiopathic aplastic anaemia
+∞
69.7
65
*
D61.1
ICD-10 Finland
Drug-induced aplastic anaemia
+∞
63.1
59
*
L03AA02
ATC
filgrastim; parenteral
13.6
58.7
58
49
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
12.5
45.7
47
42
B03XA02
ATC
darbepoetin alfa; parenteral
15.7
44.8
40
28
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.9
43.6
120
316
ZX120
NOMESCO Finland
Intravenous
5.7
43.3
95
206
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
7.1
40.8
67
109
D61.8
ICD-10 Finland
Other specified aplastic anaemias
+∞
40.2
38
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.3
31.2
175
737
L04AA01
ATC
[U] ciclosporin
29.7
28.5
38
14
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.0
26.6
248
1363
NEA10
NOMESCO Finland
Exploration of soft tissue of pelvis, percutaneous
143.8
25.9
27
*
H02AB06
ATC
prednisolone; systemic
2.9
25.5
251
1409
R50.9
ICD-10 Finland
Fever, unspecified
3.5
25.3
110
390
L04AX01
ATC
azathioprine; systemic
6.6
25.0
42
69
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.3
23.6
114
429
H02AB09
ATC
hydrocortisone; systemic
8.9
23.4
30
36
A04AA01
ATC
ondansetron; systemic, rectal
4.3
22.7
65
172
127
Kela drug reimbursment
Transplant complication
23.0
22.5
32
15
WW200
NOMESCO Finland
Immunization
8.1
22.4
31
41
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.6
22.2
85
276
J01MA12
ATC
levofloxacin; systemic
3.1
22.0
119
477
B02BX05
ATC
eltrombopag; oral
84.7
21.9
24
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.7
21.9
181
910
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
5.3
21.9
47
98
Z51.5
ICD-10 Finland
Palliative care
4.3
20.4
58
152
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.8
20.0
67
198
A41.9
ICD-10 Finland
Sepsis, unspecified
6.0
20.0
37
67
JN4AD
NOMESCO Finland
Body CT examination
3.8
19.8
67
199
C92.0
ICD-10 Finland
Acute myeloblastic leukaemia [AML]
42.3
19.7
24
6
D46.9
ICD-10 Finland
Myelodysplastic syndrome, unspecified
48.4
19.4
23
5
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
27.6
19.4
26
10
D64.8
ICD-10 Finland
Other specified anaemias
23.9
19.3
27
12
D61.2
ICD-10 Finland
Aplastic anaemia due to other external agents
+∞
18.9
18
*
D46.7
ICD-10 Finland
Other myelodysplastic syndromes
73.3
18.9
21
*
JN4BD
NOMESCO Finland
Extensive body CT
3.5
18.5
73
240
Z94.8
ICD-10 Finland
Other transplanted organ and tissue status
46.2
18.4
22
5
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
5.3
18.2
38
77
TPH04
NOMESCO Finland
Cathetrisation of vein
2.7
17.8
125
570
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
4.4
17.6
47
117
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
18.4
17.1
26
15
M04AA01
ATC
allopurinol; systemic
3.0
16.9
89
347
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
5.0
16.7
37
79
N02AA05
ATC
oxycodone; systemic
2.7
16.6
108
471
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
6.9
15.9
25
38
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
4.3
15.9
43
108
3039, ,
Kela drug reimbursment
62.5
15.9
18
*
1517, ,
Kela drug reimbursment
62.5
15.9
18
*
D60.9
ICD-10 Finland
Acquired pure red cell aplasia, unspecified
+∞
15.7
15
*
D70.82
ICD-10 Finland
Drug-induced neutropenia
11.9
15.5
28
25
B82
ICPC
Anaemia other/unspecified
7.3
15.4
23
33
C03CA01
ATC
furosemide; systemic
2.3
15.1
172
968
A46
ICD-10 Finland
Erysipelas
2.7
13.9
84
350
B03BA03
ATC
hydroxocobalamin; parenteral
4.0
13.7
41
111
A02BC02
ATC
pantoprazole; systemic
2.3
13.6
295
2123
TGC00
NOMESCO Finland
Bronchial lavation
5.4
13.3
27
53
L04AA06
ATC
mycophenolic acid; systemic
15.7
13.2
21
14
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.3
13.1
141
765
N17.9
ICD-10 Finland
Acute renal failure, unspecified
4.6
13.1
32
74
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
6.0
12.9
23
40
ZX108
NOMESCO Finland
Inhalation
20.8
12.6
18
9
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
12.1
12.5
22
19
A05AA02
ATC
ursodeoxycholic acid; oral
11.0
12.4
23
22
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.9
11.9
63
244
C91.1
ICD-10 Finland
Chronic lymphocytic leukaemia of B-cell type
11.0
11.9
22
21
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
5.1
11.8
25
51
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.6
11.7
40
119
V03AC03
ATC
deferasirox; oral
123.2
11.5
12
*
UJF32
NOMESCO Finland
Coloscopy
2.2
11.5
123
662
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
8.9
11.2
23
27
J05AB01
ATC
aciclovir; systemic
2.3
11.2
105
535
Z31.5
ICD-10 Finland
Genetic counselling
3.8
10.7
33
91
A03FA01
ATC
metoclopramide; systemic, rectal
2.2
10.5
105
547
9989/3-C42.1
ICD-O-3
Myelodysplastic syndrome, NOS, of bone marrow
112.7
10.5
11
*
K92.1
ICD-10 Finland
Melaena
3.7
10.4
34
98
J01MA14
ATC
moxifloxacin; systemic
2.9
10.1
51
192
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.8
9.9
54
212
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.9
9.6
226
1587
AA1AD
NOMESCO Finland
CT of head and brain
2.0
9.5
126
728
B02AA02
ATC
tranexamic acid; systemic
2.5
9.5
62
267
GD1AD
NOMESCO Finland
Thorax CT examination
3.4
9.4
34
105
L03AA13
ATC
pegfilgrastim; parenteral
3.8
9.3
29
81
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.6
9.2
59
251
TK800
NOMESCO Finland
Hemodialysis
8.0
9.2
20
26
Z3231
NOMESCO Finland
Registered nurse
2.0
9.2
132
785
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
3.6
9.1
30
87
PJ2AE
NOMESCO Finland
Lymphnode ultrasound examination
37.5
9.1
11
*
H02AB02
ATC
dexamethasone; systemic
2.6
9.0
57
241
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.0
8.8
112
635
TPX10
NOMESCO Finland
Implantation of vascular injection port
4.2
8.6
23
57
B03XA01
ATC
erythropoietin; parenteral
11.9
8.6
15
13
9861/3-C42.1
ICD-O-3
Acute myeloid leukemia, NOS, of bone marrow
28.2
8.5
11
*
SPAT1088
SPAT
Blood transfusion
28.2
8.5
11
*
WX892
NOMESCO Finland
Monitored bed care
2.8
8.5
43
162
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
4.5
8.5
21
49
9823/3-C42.1
ICD-O-3
B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma of bone marrow
13.1
8.4
14
11
28409
ICD-8 Finland
Aplastic anaemia, Unspecified
+∞
8.4
8
*
D60.8
ICD-10 Finland
Other acquired pure red cell aplasias
+∞
8.4
8
*
ZXD05
NOMESCO Finland
Urgent procedure
1.9
8.0
137
857
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
8.0
7.9
17
22
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
3.5
7.9
28
85
D75.9
ICD-10 Finland
Disease of blood and blood-forming organs, unspecified
13.4
7.9
13
10
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
4.5
7.8
19
44
EP1AE
NOMESCO Finland
Neck ultrasound examination
3.1
7.7
32
108
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
6.9
7.7
18
27
1XC02, ,
NOMESCO Finland
18.8
7.6
11
6
J02AC03
ATC
voriconazole; systemic
25.5
7.6
10
*
R79.8
ICD-10 Finland
Other specified abnormal findings of blood chemistry
25.5
7.6
10
*
C91.0
ICD-10 Finland
Acute lymphoblastic leukaemia [ALL]
25.5
7.6
10
*
Z49.1
ICD-10 Finland
Extracorporeal dialysis
10.3
7.6
14
14
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
3.8
7.6
23
63
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
3.1
7.5
31
104
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
4.5
7.5
18
41
C95.0
ICD-10 Finland
Acute leukaemia of unspecified cell type
81.5
7.4
8
*
D59.5
ICD-10 Finland
Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
81.5
7.4
8
*
D69.5
ICD-10 Finland
Secondary thrombocytopenia
81.5
7.4
8
*
J02AC04
ATC
posaconazole; systemic
81.5
7.4
8
*
L04AD02
ATC
tacrolimus; systemic
13.7
7.4
12
9
TPH07
NOMESCO Finland
Cathetrisation of artery
2.4
7.4
55
251
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
8.6
7.4
15
18
175
Kela drug reimbursment
Deferasirox
+∞
7.3
7
*
9961/3-C42.1
ICD-O-3
Primary myelofibrosis of bone marrow
+∞
7.3
7
*
28402
ICD-8 Finland
Aplastic anaemia, Acquisita secundaria
+∞
7.3
7
*
R18
ICD-10 Finland
Ascites
7.5
7.3
16
22
A07EA06
ATC
budesonide; oral, local oral
3.7
7.2
23
65
JN3AD
NOMESCO Finland
Abdominal CT examination
2.3
7.2
54
248
XQ848
NOMESCO Finland
Dermatological photography
4.2
7.2
19
47
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.1
7.1
73
380
D51.9
ICD-10 Finland
Vitamin B12deficiency anaemia, unspecified
10.3
7.1
13
13
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
3.7
7.0
22
62
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
14.1
6.9
11
8
XF400
NOMESCO Finland
ECG with 12 standard connections
2.0
6.9
81
444
L01BB02
ATC
mercaptopurine; oral
11.2
6.8
12
11
A11CC03
ATC
alfacalcidol; systemic
5.8
6.8
18
32
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.9
6.8
32
116
D69.1
ICD-10 Finland
Qualitative platelet defects
40.7
6.8
8
*
3AC01, ,
NOMESCO Finland
17.0
6.8
10
6
H02AB07
ATC
prednisone; oral
2.1
6.7
66
339
J05AB11
ATC
valaciclovir; oral
2.1
6.7
70
368
A10AB05
ATC
insulin aspart; parenteral
2.6
6.6
40
166
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.0
6.6
86
489
N02AX02
ATC
tramadol; systemic, rectal
1.7
6.6
178
1262
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
2.3
6.5
50
231
L04AX03
ATC
methotrexate; systemic
2.4
6.5
44
192
R06AE07
ATC
cetirizine; oral
1.7
6.5
171
1202
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
7.6
6.5
14
19
A07EC02
ATC
mesalazine; oral, rectal
3.0
6.4
28
97
JMA11
NOMESCO Finland
Laparoscopic total splenectomy
70.9
6.4
7
*
9101
FHL
Bone biopsy
70.9
6.4
7
*
D72.8
ICD-10 Finland
Other specified disorders of white blood cells
14.6
6.4
10
7
I50.9
ICD-10 Finland
Heart failure, unspecified
2.0
6.4
75
410
N03AX16
ATC
[U] pregabalin
1.9
6.3
96
573
K92.2
ICD-10 Finland
Gastrointestinal haemorrhage, unspecified
4.0
6.3
18
47
129
Kela drug reimbursment
Idiopathic thrombocytopaenia or granulocytopenia
18.3
6.3
9
5
2848X
ICD-9 Finland
Aplastic anaemia, Other specified aplastic anaemias[ANAEMIA APLASTICA ACQUISITA NON DEFINITA]
+∞
6.3
6
*
D69.4
ICD-10 Finland
Other primary thrombocytopenia
+∞
6.3
6
*
2848D
ICD-9 Finland
Aplastic anaemia, Other specified aplastic anaemias[ANAEMIA APLASTICA ALIA DEFINITA]
+∞
6.3
6
*
T86.0
ICD-10 Finland
Bone-marrow transplant rejection
27.1
6.2
8
*
D47.1
ICD-10 Finland
Chronic myeloproliferative disease
27.1
6.2
8
*
L01BA01
ATC
methotrexate; systemic
3.6
6.2
20
57
A08.4
ICD-10 Finland
Viral intestinal infection, unspecified
3.5
6.1
21
63
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.9
6.0
84
487

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
103
25
54.10
175.81
1.6
1.2
—
—
—
0
0
103
28
48.27
170.90
1.9
1.2
—
—
—
0
0
111
44
33.82
164.51
2.4
1.8
—
—
—
0
0
141
112
18.36
153.13
2.6
1.6
1.22
1.43
g/l
1.17
117
99
220
355
11.80
147.27
11.5
2.4
1.95
1.69
%
2.02
206
319
187
260
12.08
139.82
11.6
2.2
63.61
68.46
e9/l
0.75
151
203
132
253
7.12
70.62
3.9
2.5
10.27
10.29
g/l
0.01
124
234
51
26
22.16
66.99
2.3
1.8
0.99
1.13
e9/l
0.28
40
21
64
52
14.32
66.47
1.5
1.4
—
—
—
0
0
59
44
15.41
64.31
1.7
1.3
98.75
84.41
u/ml
—
12
9
161
421
5.55
61.03
3.9
2.1
2.05
2.34
g/l
8.30
155
386
61
53
13.28
60.70
1.4
1.5
281.58
239.00
u/ml
0.29
36
29
166
469
5.17
56.94
4.0
2.2
18.89
13.48
umol/l
6.41
161
430
152
400
5.36
56.73
4.0
2.2
38.30
23.27
%
8.05
136
348
108
208
6.63
56.65
2.3
1.5
1.43
1.22
g/l
0.37
94
192
112
241
5.96
52.06
3.2
2.9
65.24
66.55
g/l
0.92
104
216
100
194
6.44
51.80
2.1
2.9
—
—
—
0
0
41
24
18.81
50.33
2.2
1.8
408.97
467.05
e6/l
0.23
30
19
305
1487
4.75
49.01
24.4
6.0
—
—
—
0
0
71
102
8.16
48.59
1.5
1.4
—
—
—
0
0
65
86
8.75
47.62
2.4
4.8
47.81
141.23
mg/l
0.63
52
66
40
25
17.56
47.52
1.3
1.4
—
—
—
0
0
159
493
4.56
47.39
7.7
3.5
0.78
0.81
mmol/l
3.46
150
464
39
24
17.79
46.67
1.2
1.2
—
—
—
0
0
64
86
8.59
46.26
2.4
4.8
33.79
30.44
mg/l
0.24
51
68
63
85
8.53
45.36
2.4
4.7
3.50
2.47
ratio
—
7
12
101
224
5.61
45.00
1.6
1.4
—
—
—
0
0
40
28
15.67
44.78
2.6
2.9
—
—
—
0
0
202
784
4.01
43.53
3.1
2.0
3.14
3.00
mg/l
0.29
172
669
292
1457
4.23
43.44
21.5
5.6
0.55
0.63
%
1.84
281
1363
297
1508
4.24
42.88
23.2
5.8
9.27
8.61
%
2.02
289
1416
46
44
11.61
42.70
1.1
1.0
—
—
—
0
0
295
1496
4.19
42.54
22.0
5.5
2.35
2.79
%
2.56
287
1401
45
44
11.32
41.13
8.5
1.8
—
—
—
0
0
298
1547
4.12
40.91
22.5
5.7
34.10
27.56
%
8.73
289
1455
51
60
9.53
40.83
2.5
5.1
—
—
—
0
0
303
1595
4.15
40.65
20.5
5.4
0.51
0.60
e9/l
4.65
275
1393
303
1600
4.13
40.34
20.5
5.4
0.03
0.04
e9/l
6.96
274
1399
293
1526
3.98
39.50
21.2
5.4
50.17
57.49
%
11.24
284
1436
305
1651
4.02
38.35
22.9
5.8
0.13
0.19
e9/l
8.60
277
1460
196
799
3.70
38.26
5.5
2.8
1811.06
8265.87
umol/l
1.99
179
686
303
1644
3.95
37.70
20.8
5.5
2.10
2.01
e9/l
0.11
278
1470
122
362
4.33
37.59
1.8
1.4
—
—
—
0
0
42
47
9.81
34.79
1.1
1.1
—
—
—
0
0
118
365
4.09
34.05
5.9
3.2
10.22
8.64
umol/l
0.22
104
324
95
254
4.53
33.25
10.5
4.2
1.08
1.06
%
0.02
73
98
296
1673
3.55
32.52
17.3
6.0
12.98
11.91
umol/l
0.68
290
1577
96
263
4.43
32.52
1.7
1.3
—
—
—
0
0
316
1869
3.71
32.08
34.2
8.6
3.15
4.21
e9/l
4.30
295
1640
135
478
3.68
31.80
1.8
1.6
—
—
—
0
0
259
1378
3.26
30.92
5.9
2.5
438.44
119.55
ug/l
9.39
247
1252
37
9
44.91
30.46
1.2
1.2
—
—
—
0
0
42
58
7.93
29.36
1.4
1.8
—
—
—
0
0
35
40
9.45
28.44
9.1
1.8
35.66
33.77
pg
1.86
35
40
255
1389
3.10
28.39
10.6
4.6
34.17
35.51
g/l
3.05
246
1295
147
592
3.27
27.73
2.0
1.8
—
—
—
0
0
197
941
3.04
27.58
8.4
3.9
—
—
—
0
0
94
287
3.92
27.16
2.7
2.5
0.21
0.21
g/l
0.19
85
264
81
227
4.17
26.31
10.8
4.0
0.60
0.56
%
0.08
62
78
147
608
3.17
26.31
2.1
1.7
1252.19
1169.26
nmol/l
0.43
126
454
32
8
43.15
26.21
1.2
1.3
—
—
—
0
0
54
109
5.53
26.13
1.5
2.6
10.63
10.12
g/l
0.31
49
94
79
220
4.18
25.86
11.3
4.3
0.39
0.06
%
1.12
59
65
205
1039
2.88
25.19
14.3
2.4
—
—
—
0
0
81
236
4.01
24.87
10.8
4.3
0.09
0.11
%
0.15
60
80
31
37
8.96
24.30
5.9
3.9
—
—
—
0
0
165
773
2.86
23.11
2.3
1.5
18.88
20.73
nmol/l
1.00
152
645
267
1605
2.79
22.85
15.9
6.6
1.20
1.21
mmol/l
1.56
233
1364
153
694
2.88
22.71
2.8
1.7
1.34
1.18
mg/l
0.42
117
526
46
95
5.31
21.61
1.6
2.8
36.81
38.17
g/l
0.72
41
81
228
1299
2.63
21.21
3.1
2.0
87.97
93.63
pmol/l
1.06
159
673
164
797
2.72
21.05
13.1
2.2
—
—
—
0
0
187
974
2.65
20.83
9.5
3.7
7.40
7.40
ph
0.11
34
171
144
659
2.79
20.73
2.1
1.4
2.28
2.43
g/l
0.44
112
402
166
827
2.66
20.10
25.5
6.5
—
—
—
0
0
24
7
36.21
19.10
1.0
1.0
—
—
—
0
0
245
1505
2.49
18.59
14.0
2.6
—
—
—
0
0
102
413
2.94
18.20
1.5
1.3
390.00
457.26
titre
0.14
16
95
188
1039
2.45
17.81
5.9
3.1
32.00
31.82
u/l
0.03
175
988
240
1488
2.41
17.45
14.7
6.0
1.20
1.21
mmol/l
1.82
230
1333
22
7
33.03
17.20
1.3
1.3
—
—
—
0
0
234
1451
2.37
16.78
29.0
8.9
0.08
0.00
e9/l
0.51
207
1184
245
1556
2.36
16.54
16.9
15.6
1.36
1.31
inr
0.08
76
444
23
11
22.02
16.15
2.3
2.2
114.55
303.33
e6/l
—
11
6
26
18
15.30
16.05
3.3
2.9
40.22
48.22
%
—
17
9
27
47
6.07
15.12
8.6
3.6
48.37
58.04
%
1.58
27
47
26
46
5.96
14.32
5.8
3.2
2.75
4.27
e9/l
1.87
26
46
29
57
5.39
14.31
1.2
1.2
—
—
—
0
0
277
1922
2.27
14.26
10.4
4.8
6.67
6.67
mmol/l
0.01
271
1785
74
296
2.82
13.24
2.6
1.9
364.47
385.01
nmol/l
0.40
68
275
163
938
2.20
13.15
5.1
3.1
0.49
0.54
e6/l
0.08
132
707
157
906
2.16
12.44
5.0
3.0
—
—
—
0
0
173
1040
2.12
12.30
5.1
3.1
113.15
69.52
e6/l
0.23
139
799
324
2492
2.27
11.68
23.1
7.0
87.92
78.39
u/l
1.57
318
2318
35
96
3.88
11.48
4.4
2.7
—
—
—
0
0
189
1198
2.04
11.45
6.0
3.7
56.67
72.78
e6/l
0.38
145
846
15
6
25.82
11.21
1.4
1.5
—
—
—
0
0
18
14
13.37
10.74
2.2
3.2
1104.39
633.21
u/ml
0.60
18
14
84
401
2.37
10.32
2.4
1.6
—
—
—
0
0
94
475
2.26
10.10
2.6
1.9
—
—
—
0
0
55
217
2.76
10.01
4.2
2.9
6.07
6.84
e9/l
0.11
46
176
107
572
2.16
10.00
4.5
2.7
0.87
1.10
e6/l
0.53
68
331
191
1265
1.93
9.78
3.4
2.3
72.42
76.76
nmol/l
1.38
180
1112
170
1087
1.94
9.64
5.3
3.0
2.33
2.35
mmol/l
1.25
156
957
64
278
2.53
9.62
17.9
7.6
—
—
—
0
0
31
89
3.68
9.53
1.1
1.2
—
—
—
0
0
123
707
2.04
9.43
3.5
2.5
4.78
4.89
e6/l
0.04
116
630
100
546
2.09
8.74
4.7
2.9
1.64
2.08
e6/l
0.37
60
306
75
366
2.27
8.68
9.4
8.0
-0.30
1.39
mmol/l
1.87
62
294
14
12
12.02
8.13
1.1
1.0
—
—
—
0
0
29
89
3.42
8.09
1.3
1.4
239.38
326.41
ug/g
1.13
19
50
154
999
1.85
8.04
4.2
2.6
54.02
62.56
u/l
0.90
146
926
41
157
2.78
7.88
9.1
12.0
—
—
—
0
0
111
653
1.95
7.79
1.9
1.7
426.43
435.93
pmol/l
0.13
97
537
152
997
1.82
7.57
4.0
3.0
2778.61
1370.41
ng/l
1.89
136
842
109
647
1.92
7.41
4.5
3.7
1875.84
230.83
ng/l
0.57
102
510
13
12
11.13
7.34
5.1
1.4
—
—
—
0
0
113
685
1.89
7.19
4.1
2.8
530.22
562.18
mosm/kgh2o
0.84
102
580
149
1002
1.75
6.66
2.4
2.0
661.87
290.19
u/l
0.34
141
937
63
322
2.12
6.45
12.8
3.8
1.78
1.91
mmol/l
0.08
54
251
28
98
2.99
6.33
1.2
1.3
109.14
331.07
miu/ml
—
7
43
271
2170
1.69
6.14
6.9
4.5
29.50
2685.49
e6/l
—
6
41
131
872
1.73
5.96
1.8
1.4
—
—
—
0
0
293
2405
1.71
5.96
7.4
3.9
23.24
11.61
mm/h
13.08
280
2200
19
54
3.64
5.95
1.3
1.4
0.61
0.61
g/l
0.00
12
47
14
22
6.54
5.90
6.0
2.3
—
—
—
0
0
281
2286
1.68
5.86
7.1
4.2
—
—
—
0
0
11
12
9.37
5.82
2.8
1.8
27.27
28.33
umol/l
0.08
11
12
102
637
1.79
5.77
4.1
3.0
2.45
2.45
mmol/l
0.08
92
559
16
31
5.32
5.76
1.1
1.1
—
—
—
0
0
15
28
5.51
5.58
2.3
2.8
—
—
—
0
0
70
398
1.91
5.31
2.3
1.4
—
—
—
0
0
38
172
2.33
5.21
2.6
2.4
—
—
—
0
0
45
219
2.18
5.21
3.4
6.3
—
—
—
0
0
15
32
4.82
5.04
1.3
1.3
4.15
2.19
g/l
—
8
25
15
32
4.82
5.04
1.3
1.3
0.41
0.30
g/l
—
8
26
15
32
4.82
5.04
1.3
1.3
7.35
6.24
g/l
—
8
26
9
10
9.16
4.80
1.1
1.5
—
—
—
0
0
9
10
9.16
4.80
1.9
2.0
—
—
—
0
0
15
34
4.53
4.79
1.3
1.2
—
—
—
0
0
14
32
4.49
4.47
6.0
2.3
—
—
—
0
0
60
344
1.87
4.43
1.7
1.3
—
—
—
0
0
107
726
1.63
4.37
5.2
3.8
—
—
—
0
0
14
33
4.35
4.36
1.0
1.2
—
—
—
0
0
70
424
1.78
4.33
1.4
1.2
—
—
—
0
0
64
379
1.81
4.26
4.1
2.3
273.15
111.83
ug/g
1.05
56
296
77
482
1.73
4.25
1.4
1.2
3.60
10.79
u/ml
1.16
21
186
56
321
1.86
4.14
2.2
4.4
4.64
20.54
ug/l
0.65
46
268
168
1284
1.51
4.03
4.5
3.8
30.47
43.10
ng/l
1.18
139
911
16
53
3.10
4.00
3.4
3.2
—
—
—
0
0
19
70
2.79
3.97
11.6
4.2
—
—
—
0
0
27
119
2.36
3.96
2.2
1.8
—
—
—
0
0
17
59
2.96
3.94
1.5
1.2
17.20
7.70
u/ml
—
5
27
8
11
7.39
3.87
1.3
1.7
—
—
—
0
0
137
1014
1.52
3.78
4.7
3.1
—
—
—
0
0
198
1580
1.47
3.77
7.9
5.0
0.00
0.00
estimate
-0.00
34
290
199
1598
1.46
3.63
5.4
3.6
0.00
0.00
estimate
-0.00
35
281
7
9
7.88
3.57
2.0
1.7
—
—
—
0
0
8
13
6.25
3.51
1.3
1.2
—
—
—
0
0
197
1589
1.45
3.46
5.4
3.6
0.00
0.00
estimate
0.50
36
316
26
121
2.22
3.39
1.0
1.1
—
—
—
0
0
9
18
5.08
3.38
1.2
1.3
—
—
—
0
0
7
10
7.10
3.37
1.6
1.1
—
—
—
0
0
8
14
5.80
3.35
2.0
1.9
—
—
—
0
0
18
73
2.53
3.17
2.6
2.4
—
—
—
0
0
76
1080
0.64
3.13
3.1
2.8
—
—
—
0
0
48
287
1.76
3.11
3.4
3.2
304.54
184.32
ng/l
0.56
41
257
6
8
7.59
3.06
2.8
1.5
—
—
—
0
0
76
516
1.58
3.04
1.4
1.2
57.58
33.89
iu/ml
0.49
28
162
160
1265
1.43
3.03
5.5
3.4
5.75
5.92
ph
—
8
96
246
2101
1.41
2.97
5.0
3.1
62.01
47.91
u/l
1.29
237
1945
41
239
1.79
2.90
13.8
4.8
7.41
7.41
ph
—
7
26
7
13
5.45
2.88
1.0
1.0
—
—
—
0
0
45
271
1.74
2.86
5.5
3.5
—
—
—
0
0
18
77
2.40
2.86
1.4
1.2
—
—
—
0
0
49
303
1.70
2.83
1.6
1.6
—
—
—
0
0
47
289
1.70
2.78
2.3
2.5
7.92
7.03
ug/l
0.13
41
255
14
55
2.60
2.64
13.4
4.1
59.79
60.73
%
0.05
14
55
7
15
4.73
2.60
5.9
7.3
28.93
40.87
%
—
7
15
97
717
1.46
2.60
1.4
1.3
0.54
1.50
u/ml
2.03
20
191
8
20
4.06
2.58
3.5
2.4
—
—
—
0
0
5
7
7.21
2.55
3.0
1.9
—
—
—
0
0
6
11
5.51
2.55
1.0
1.0
—
—
—
0
0
33
188
1.82
2.53
1.8
1.2
947.07
320.96
u/ml
0.56
28
164
10
31
3.28
2.53
1.8
1.4
86.80
64.09
%
—
5
23
11
37
3.02
2.50
4.0
3.2
—
—
—
0
0
10
250
0.39
2.45
1.3
1.4
—
—
—
0
0
31
176
1.82
2.41
15.5
5.2
—
—
—
0
0
9
28
3.26
2.32
1.8
1.1
—
—
—
0
0
7
18
3.94
2.26
8.4
9.2
8.23
12.15
%
—
7
18
15
68
2.25
2.13
1.0
1.5
—
—
—
0
0
29
170
1.76
2.06
5.8
3.5
—
—
—
0
0
30
180
1.72
1.98
5.8
3.2
4.62
4.65
pmol/l
0.04
22
160
14
64
2.23
1.96
7.6
2.7
—
—
—
0
0
14
64
2.23
1.96
1.8
1.6
10579.43
16553.28
e6/l
—
7
47
8
27
3.00
1.94
1.0
1.0
—
—
—
0
0
22
122
1.85
1.88
4.6
5.0
—
—
—
0
0
14
66
2.16
1.84
8.6
3.4
2.69
2.56
mmol/l
—
9
40
23
131
1.80
1.81
2.5
2.6
—
—
—
0
0
7
23
3.08
1.80
1.1
1.3
—
—
—
0
0
14
67
2.13
1.78
3.6
3.2
—
—
—
0
0
14
67
2.13
1.78
3.9
2.5
12.10
16.14
%
—
7
35
37
242
1.58
1.78
1.2
1.2
—
—
—
0
0
6
18
3.37
1.75
1.7
1.6
13.55
21.63
umol/l
—
6
18
9
36
2.53
1.75
1.2
1.4
—
—
—
0
0
152
1283
1.29
1.69
2.7
2.0
—
—
—
0
0
11
50
2.23
1.58
2.4
1.5
—
—
—
0
0
5
15
3.36
1.52
1.0
2.3
9.60
9.13
mmol/l
—
5
15
5
15
3.36
1.52
1.2
1.1
131.20
184.80
mmol/24h
—
5
15
112
920
1.30
1.52
3.9
3.2
1723.77
266.58
mg/l
0.91
87
601
18
101
1.82
1.51
2.2
1.5
26.01
23.12
iu/l
0.10
11
84
29
187
1.59
1.50
1.2
1.2
—
—
—
0
0
21
125
1.72
1.46
4.8
3.3
0.17
0.20
g/l
0.26
13
46
7
28
2.52
1.45
1.1
1.2
—
—
—
0
0
9
39
2.34
1.44
1.0
1.3
0.59
0.47
nmol/l
—
9
34
9
39
2.34
1.44
2.2
1.8
91.93
90.49
%
—
9
39
262
2394
1.25
1.41
4.6
3.7
15.04
14.87
pmol/l
0.51
250
2123
21
326
0.63
1.29
1.7
1.7
—
—
—
0
0
245
2236
1.23
1.28
4.3
3.9
—
—
—
0
0
8
35
2.31
1.27
1.6
2.0
—
—
—
0
0
8
35
2.31
1.27
2.0
1.6
—
—
—
0
0
40
289
1.42
1.25
1.5
1.4
—
—
—
0
0
275
2944
0.81
1.23
6.6
5.8
39.96
39.95
mmol/mol
0.01
254
2719
118
1001
1.25
1.22
4.0
3.0
6.89
7.70
mmol/l
1.05
103
832
8
37
2.18
1.22
1.0
1.3
—
—
—
0
0
42
308
1.40
1.21
8.3
4.0
—
—
—
0
0
26
173
1.54
1.21
2.0
1.3
—
—
—
0
0
344
3272
1.27
1.15
47.1
14.1
22.37
24.75
mg/l
0.91
318
2599
10
51
1.98
1.12
1.0
1.5
—
—
—
0
0
5
22
2.29
1.03
1.0
1.5
1.69
1.87
mmol/l
—
5
22
7
34
2.08
1.03
1.3
1.2
—
—
—
0
0
11
61
1.82
0.99
3.0
3.1
0.85
0.90
nmol/l
—
6
48
299
2820
1.20
0.98
60.2
16.7
15.71
14.82
%
2.75
299
2776
26
183
1.45
0.96
1.3
1.3
111.86
131.42
iu/ml
—
7
75
67
804
0.80
0.90
1.7
1.6
1.44
1.34
mmol/l
0.56
58
671
29
212
1.39
0.89
2.9
2.7
—
—
—
0
0
49
389
1.29
0.89
1.7
1.3
—
—
—
0
0
293
3080
0.84
0.87
5.4
4.5
6.09
5.97
mmol/l
0.61
266
2788
6
31
1.95
0.84
1.0
1.4
—
—
nmol/l
—
0
0
6
31
1.95
0.84
1.2
1.3
—
—
—
0
0
309
2941
1.19
0.83
5.4
4.5
2.08
2.34
mu/l
0.27
289
2655
304
3179
0.85
0.81
4.8
4.9
2.50
2.69
mmol/l
3.52
288
2906
351
3624
0.82
0.80
72.1
20.5
185.40
245.48
e9/l
22.75
346
3531
7
121
0.57
0.79
1.3
1.1
—
—
—
0
0
107
943
1.18
0.75
4.8
4.0
—
—
—
0
0
352
3627
0.83
0.73
71.7
20.5
5.98
6.84
e9/l
2.98
344
3523
7
39
1.81
0.73
2.9
3.0
1.19
3.07
nmol/l
—
7
39
352
3626
0.83
0.72
71.8
20.5
3.76
4.51
e12/l
54.29
345
3521
352
3625
0.83
0.71
72.5
20.6
35.06
40.24
%
36.54
336
3390
5
26
1.93
0.71
1.4
1.2
—
—
—
0
0
296
3089
0.86
0.70
4.3
4.3
1.34
1.44
mmol/l
3.60
277
2828
82
712
1.19
0.68
5.7
4.0
1.01
1.02
kg/l
1.04
14
107
299
3115
0.86
0.67
4.4
4.4
4.32
4.55
mmol/l
3.63
286
2863
15
103
1.47
0.66
2.5
1.2
—
—
—
0
0
0
20
0.00
0.60
0.0
20.4
—
1889.75
—
0
20
0
20
0.00
0.60
0.0
10.6
—
961.95
—
0
20
12
80
1.51
0.60
3.0
2.0
29.57
144.28
ug/min
—
7
50
34
274
1.26
0.59
4.6
3.5
—
—
—
0
0
108
977
1.14
0.54
5.1
3.8
28.40
8.92
mg/mmol
0.93
81
605
7
48
1.47
0.47
2.1
2.3
—
—
—
0
0
13
175
0.73
0.45
1.3
1.4
—
—
—
0
0
95
867
1.12
0.43
5.5
3.9
0.00
0.00
estimate
0.50
34
285
5
32
1.57
0.42
1.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
7.1
—
—
—
0
0
0
17
0.00
0.40
0.0
6.9
—
0.65
—
0
17
0
17
0.00
0.40
0.0
1.2
—
—
—
0
0
5
34
1.48
0.40
1.0
1.1
—
—
—
0
0
8
60
1.34
0.40
1.3
1.5
—
—
—
0
0
5
35
1.43
0.39
1.4
1.7
—
—
—
0
0
5
35
1.43
0.39
1.0
1.7
—
—
—
0
0
77
698
1.13
0.39
2.8
3.1
0.86
0.81
ug/l
0.10
58
466
6
43
1.40
0.35
1.2
1.2
—
—
—
0
0
6
44
1.37
0.34
1.3
1.4
—
—
—
0
0
22
186
1.19
0.28
3.2
2.6
0.28
0.24
e6/l
0.08
22
180
13
103
1.27
0.28
9.6
4.0
—
—
—
0
0
8
63
1.27
0.28
1.3
1.3
—
—
—
0
0
8
67
1.20
0.26
1.3
1.2
—
—
—
0
0
95
896
1.08
0.23
5.3
3.2
—
—
—
0
0
293
2988
0.94
0.23
4.2
3.9
1.40
1.27
mmol/l
2.17
275
2722
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
336
3407
0.93
0.20
35.0
13.0
—
—
—
0
0
14
122
1.15
0.14
1.2
1.4
—
—
—
0
0
24
220
1.10
0.12
2.4
2.4
—
16.59
—
0
14
26
240
1.09
0.11
1.5
1.4
—
—
—
0
0
32
301
1.07
0.09
1.3
1.5
—
—
—
0
0
117
1198
0.97
0.09
5.1
5.0
3.54
3.06
ug/l
0.13
106
1062
14
133
1.05
0.01
1.4
1.4
—
—
—
0
0
14
133
1.05
0.01
1.3
1.4
—
—
—
0
0
14
147
0.95
0.01
1.4
1.3
—
—
—
0
0
10
106
0.94
0.01
1.3
1.4
—
—
—
0
0
14
134
1.05
0.00
1.3
1.4
—
—
—
0
0
13
135
0.96
0.00
1.3
1.4
—
—
—
0
0
10
103
0.97
0.00
17.7
9.7
—
—
—
0
0
11
112
0.98
0.00
1.3
1.6
—
—
—
0
0
12
121
0.99
0.00
1.5
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
92.16
—
0
5
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.5
—
19.03
—
0
6
7
69
1.01
-0.00
2.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
89
1.01
-0.00
1.7
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
7
76
0.92
-0.00
1.1
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
4.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
—
—
0
0
7
70
1.00
-0.00
1.0
1.1
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint D3_OTHERAPLASTICANAEMIA and mortality.

Females

Parameter HR [95% CI] p-value
D3_OTHERAPLASTICANAEMIA 4.14 [3.24, 5.29] < 0.001
Birth year 0.995 [0.99, 1.0] 0.266

During the follow-up period (1.1.1998 — 31.12.2019), 646 out of 1166 females with D3_OTHERAPLASTICANAEMIA died.

Males

Parameter HR [95% CI] p-value
D3_OTHERAPLASTICANAEMIA 3.95 [3.02, 5.16] < 0.001
Birth year 0.991 [0.98, 1.0] 0.051

During the follow-up period (1.1.1998 — 31.12.2019), 660 out of 1238 males with D3_OTHERAPLASTICANAEMIA died.

Mortality risk

Mortality risk for people of age

years, who have D3_OTHERAPLASTICANAEMIA.

N-year risk Females Males
1 0.339% 0.703%
5 2.533% 4.934%
10 5.664% 12.691%
15 10.663% 22.855%
20 18.979% 36.188%

Relationships between endpoints

↥

Index endpoint: D3_OTHERAPLASTICANAEMIA – Other and unspecified aplastic anaemias

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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