No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
395 |
4. Check minimum number of eventsNone |
395 |
5. Include endpointsNone |
395 |
6. Filter based on genotype QC (FinnGen only) |
395 |
Control definitions (FinnGen only)
- Control exclude
- D3_APLASTICANDOTHANAEMIA
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D60-D64
- Name in latin
- Aliae anaemia aplasticae
Similar endpoints
↥List of similar endpoints to
Other and unspecified aplastic anaemias
based on the number of shared cases.
Similar with more cases:
- Aplastic and other anaemias
- Anaemias
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4109 | 2037 | 1985 |
| Only index persons | 2722 | 1371 | 1351 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.06 | 0.06 |
| Only index persons | 0.05 | 0.05 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 64.32 | 65.00 | 63.49 |
| Only index persons | 61.52 | 61.81 | 61.22 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 395 | 192 | 203 |
| Unadjusted period prevalence (%) | 0.08 | 0.07 | 0.09 |
| Median age at first event (years) | 60.46 | 54.48 | 66.11 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 374
- Matched controls
- 3740
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D61.9
ICD-10 Finland
Aplastic anaemia, unspecified
+∞
195.4
170
*
D64.9
ICD-10 Finland
Anaemia, unspecified
49.9
126.5
153
51
XW000
NOMESCO Finland
Bone marrow biopsy
36.4
105.9
138
59
122
Kela drug reimbursment
Aplastic anaemia
+∞
101.8
93
*
WW500
NOMESCO Finland
Blood transfusion
30.7
79.0
107
48
D61.0
ICD-10 Finland
Constitutional aplastic anaemia
+∞
70.0
65
*
D61.3
ICD-10 Finland
Idiopathic aplastic anaemia
+∞
60.0
56
*
L04AD01
ATC
ciclosporin; systemic
37.4
57.2
73
24
D61.1
ICD-10 Finland
Drug-induced aplastic anaemia
+∞
55.6
52
*
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
45.1
52.4
64
17
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
112.3
46.0
49
5
D70.89
ICD-10 Finland
Neutropenic splenomegaly
70.9
39.0
44
7
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
11.5
35.7
69
72
L03AA02
ATC
filgrastim; parenteral
16.2
31.2
51
36
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.8
28.9
109
292
D61.8
ICD-10 Finland
Other specified aplastic anaemias
+∞
28.5
27
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.7
27.4
158
619
ZX120
NOMESCO Finland
Intravenous
5.8
26.2
81
171
R50.9
ICD-10 Finland
Fever, unspecified
4.6
26.0
103
286
H02AB06
ATC
prednisolone; systemic
3.2
25.6
222
1167
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.2
25.6
215
1104
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
7.5
25.2
62
96
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
12.6
24.9
45
40
L04AA01
ATC
[U] ciclosporin; systemic
15.5
23.2
38
27
B03XA02
ATC
darbepoetin alfa; parenteral
22.5
23.0
33
16
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
51.0
20.4
24
5
D61.2
ICD-10 Finland
Aplastic anaemia due to other external agents
+∞
20.0
19
*
127
Kela drug reimbursment
Transplant complication
19.0
19.9
30
17
NEA10
NOMESCO Finland
Exploration of soft tissue of pelvis, percutaneous
58.2
19.1
22
*
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
20.0
18.9
28
15
Z94.8
ICD-10 Finland
Other transplanted organ and tissue status
44.2
17.5
21
5
D46.9
ICD-10 Finland
Myelodysplastic syndrome, unspecified
44.2
17.5
21
5
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.4
16.7
91
322
A04AA01
ATC
ondansetron; systemic, rectal
5.8
16.6
48
92
C92.0
ICD-10 Finland
Acute myeloblastic leukaemia [AML]
25.8
16.2
22
9
J01MA12
ATC
levofloxacin; systemic
3.1
16.2
103
407
TPH04
NOMESCO Finland
Cathetrisation of vein
3.0
16.0
109
451
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.8
15.6
72
223
JN4BD
NOMESCO Finland
Extensive body CT
3.8
15.3
70
215
D46.7
ICD-10 Finland
Other myelodysplastic syndromes
59.1
14.9
17
*
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
5.1
14.6
47
102
A41.9
ICD-10 Finland
Sepsis, unspecified
7.0
14.6
36
56
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
7.0
14.6
36
56
C03CA01
ATC
furosemide; systemic
2.5
14.4
144
739
WW200
NOMESCO Finland
Immunization
8.6
14.4
31
39
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.3
13.9
53
137
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.5
13.9
150
800
D70.82
ICD-10 Finland
Drug-induced neutropenia
14.3
13.9
23
17
D60.9
ICD-10 Finland
Acquired pure red cell aplasia, unspecified
+∞
13.6
13
*
B02BX05
ATC
eltrombopag; oral
144.9
13.5
14
*
A05AA02
ATC
ursodeoxycholic acid; oral
12.9
12.8
22
18
A02BC02
ATC
pantoprazole; systemic
2.3
12.7
247
1723
H02AB09
ATC
hydrocortisone; systemic
8.5
12.6
27
34
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
4.9
12.4
41
92
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
7.8
11.9
27
37
ZX108
NOMESCO Finland
Inhalation
17.7
11.3
17
10
C91.1
ICD-10 Finland
Chronic lymphocytic leukaemia of B-cell type
14.5
11.1
18
13
L04AA06
ATC
mycophenolic acid; systemic
12.4
11.0
19
16
L04AX01
ATC
azathioprine; systemic
5.1
10.9
34
72
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.3
10.7
116
605
3039
Kela drug reimbursment
NA
113.0
10.5
11
*
1517
Kela drug reimbursment
NA
113.0
10.5
11
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
9.2
10.4
21
24
D75.9
ICD-10 Finland
Disease of blood and blood-forming organs, unspecified
33.5
10.4
13
*
N02AA05
ATC
oxycodone; systemic
2.7
10.4
76
321
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.0
10.0
194
1294
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
12.6
9.9
17
14
TK800
NOMESCO Finland
Hemodialysis
9.1
9.9
20
23
J05AB11
ATC
valaciclovir; oral
2.9
9.8
61
233
D64.8
ICD-10 Finland
Other specified anaemias
15.5
9.6
15
10
Z51.5
ICD-10 Finland
Palliative care
4.1
9.5
37
98
D59.5
ICD-10 Finland
Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
+∞
9.4
9
*
JMA11
NOMESCO Finland
Laparoscopic total splenectomy
+∞
9.4
9
*
TPX10
NOMESCO Finland
Implantation of vascular injection port
6.7
9.4
23
36
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.6
9.4
76
339
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
6.3
9.4
24
40
UJF32
NOMESCO Finland
Coloscopy
2.2
9.3
110
590
B03BA03
ATC
hydroxocobalamin; parenteral
4.0
9.2
37
101
9861/3-C42.1
ICD-O-3
Acute myeloid leukemia, NOS, of bone marrow
37.6
9.1
11
*
N17.9
ICD-10 Finland
Acute renal failure, unspecified
5.0
9.1
28
59
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.1
8.9
49
171
A46
ICD-10 Finland
Erysipelas
2.6
8.8
68
295
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
4.5
8.7
30
71
Z3231
NOMESCO Finland
Registered nurse
2.1
8.7
118
671
J02AC03
ATC
voriconazole; systemic
92.0
8.4
9
*
T86.0
ICD-10 Finland
Bone-marrow transplant rejection
92.0
8.4
9
*
Z49.1
ICD-10 Finland
Extracorporeal dialysis
13.2
8.4
14
11
M04AA01
ATC
allopurinol; systemic
2.6
8.4
67
294
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.4
8.4
40
127
WW306
NOMESCO Finland
Transfer of stem cells from foreign registered donator
+∞
8.4
8
*
28409
ICD-8 Finland
Aplastic anaemia, Unspecified
+∞
8.4
8
*
V03AC03
ATC
deferasirox; oral
+∞
8.4
8
*
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
7.8
8.3
18
24
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.0
8.1
47
172
XF400
NOMESCO Finland
ECG with 12 standard connections
2.3
8.0
77
373
L03AA13
ATC
pegfilgrastim; parenteral
5.9
7.9
21
37
H02AB07
ATC
prednisone; oral
2.5
7.9
62
271
R18
ICD-10 Finland
Ascites
8.7
7.9
16
19
J01MA14
ATC
moxifloxacin; systemic
3.1
7.7
43
151
WX892
NOMESCO Finland
Monitored bed care
3.1
7.7
43
151
A03FA01
ATC
metoclopramide; systemic, rectal
2.3
7.7
81
408
J05AB01
ATC
aciclovir; systemic
2.2
7.5
84
437
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
6.7
7.5
18
28
D69.5
ICD-10 Finland
Secondary thrombocytopenia
81.6
7.4
8
*
D69.1
ICD-10 Finland
Qualitative platelet defects
81.6
7.4
8
*
Z31.5
ICD-10 Finland
Genetic counselling
4.5
7.4
25
59
B03XA01
ATC
erythropoietin; parenteral
11.2
7.3
13
12
175
Kela drug reimbursment
Deferasirox
+∞
7.3
7
*
JN4AD
NOMESCO Finland
Body CT examination
3.3
7.3
36
118
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
16.1
7.3
11
7
H02AB04
ATC
methylprednisolone; systemic
2.4
7.2
61
277
TGC00
NOMESCO Finland
Bronchial lavation
5.2
7.2
21
42
SPAT1088
SPAT
Blood transfusion
30.6
7.2
9
*
D51.0
ICD-10 Finland
Vitamin B12deficiency anaemia due to intrinsic factor deficiency
30.6
7.2
9
*
A41.1
ICD-10 Finland
Sepsis due to other specified staphylococcus
20.5
7.2
10
5
C90.0
ICD-10 Finland
Multiple myeloma
12.3
7.1
12
10
N02AX02
ATC
tramadol; systemic, rectal
1.8
7.0
156
1049
ZXD05
NOMESCO Finland
Urgent procedure
1.9
7.0
126
792
B02AA02
ATC
tranexamic acid; systemic
2.5
6.9
54
236
H02AB02
ATC
dexamethasone; systemic
2.7
6.9
45
178
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.3
6.8
33
107
D62
ICD-10 Finland
Acute posthaemorrhagic anaemia
40.8
6.8
8
*
AA1AD
NOMESCO Finland
CT of head and brain
2.0
6.7
95
544
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
8.9
6.6
13
15
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.0
6.5
85
471
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
4.1
6.5
24
62
EP1AE
NOMESCO Finland
Neck ultrasound examination
3.6
6.5
28
83
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
8.4
6.4
13
16
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
5.7
6.4
17
31
A11CC03
ATC
alfacalcidol; systemic
5.7
6.4
17
31
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
6.1
6.4
16
27
D46.2
ICD-10 Finland
Refractory anaemia with excess of blasts [RAEB]
+∞
6.3
6
*
2848X
ICD-9 Finland
Aplastic anaemia, Other specified aplastic anaemias[ANAEMIA APLASTICA ACQUISITA NON DEFINITA]
+∞
6.3
6
*
28402
ICD-8 Finland
Aplastic anaemia, Acquisita secundaria
+∞
6.3
6
*
C95.0
ICD-10 Finland
Acute leukaemia of unspecified cell type
27.1
6.2
8
*
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.5
6.2
49
213
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.6
6.1
44
184
L01BB02
ATC
mercaptopurine; oral
8.8
6.1
12
14
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
8.8
6.1
12
14
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
6.1
80
443
B82
ICPC
Anaemia other/unspecified
6.2
6.1
15
25
I50.9
ICD-10 Finland
Heart failure, unspecified
2.2
6.0
62
310
Mortality – FinRegistry
↥Association
Association between endpoint D3_OTHERAPLASTICANAEMIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_OTHERAPLASTICANAEMIA | 4.14 [3.24, 5.29] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.266 |
During the follow-up period (1.1.1998 — 31.12.2019), 646 out of 1166 females with D3_OTHERAPLASTICANAEMIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_OTHERAPLASTICANAEMIA | 3.95 [3.02, 5.16] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.051 |
During the follow-up period (1.1.1998 — 31.12.2019), 660 out of 1238 males with D3_OTHERAPLASTICANAEMIA died.
Mortality risk
Mortality risk for people of age
years, who have D3_OTHERAPLASTICANAEMIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.339% | 0.703% |
| 5 | 2.533% | 4.934% |
| 10 | 5.664% | 12.691% |
| 15 | 10.663% | 22.855% |
| 20 | 18.979% | 36.188% |
Relationships between endpoints
↥Index endpoint: D3_OTHERAPLASTICANAEMIA – Other and unspecified aplastic anaemias
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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