This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Disorder of bilirubin metabolism, other/unspecified
E4_PORBILIRNAS
No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
49 |
4. Check minimum number of eventsNone |
49 |
5. Include endpointsNone |
49 |
6. Filter based on genotype QC (FinnGen only) |
49 |
Control definitions (FinnGen only)
- Control exclude
- E4_METABOLIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Disorder of bilirubin metabolism, other/unspecified
based on the number of shared cases.
Similar with more cases:
- Disorders of porphyrin and bilirubin metabolism
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 486 | 210 | 276 |
| Only index persons | 423 | 185 | 238 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | - | 43.10 | 42.16 |
| Only index persons | 42.70 | 45.65 | 40.40 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 49 | 19 | 30 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 56.51 | 62.50 | 52.71 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
No data available
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3034770) Mitochondria Ab [Titer] in Serum
11
6
23.01
8.02
1.5
1.2
titre
—
—
—
0
0
(40763571) Iron/Transferrin [Ratio] in Serum or Plasma
13
38
4.30
4.25
5.2
2.0
%
24.3
25.6
0.08
13
32
(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells
8
11
8.43
4.03
1.4
1.4
—
—
—
0
0
(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma
38
245
3.45
3.39
7.6
2.7
u/l
53.7
46.5
0.28
38
231
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
13
46
3.49
3.21
1.2
1.4
—
—
—
0
0
(3024561) Albumin [Mass/volume] in Serum or Plasma
27
149
2.81
3.10
10.4
6.2
g/l
36.6
35.1
0.61
27
135
(3017143) Hepatitis C virus Ab [Presence] in Serum
13
48
3.33
3.00
1.3
1.4
—
—
—
0
0
(3032080) INR in Blood by Coagulation assay
25
136
2.71
2.91
17.7
8.3
inr
1.4
1.2
—
9
48
(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma
28
166
2.60
2.68
10.4
8.3
mmol/l
1.2
1.2
0.49
21
142
(3004789) Transferrin [Mass/volume] in Serum or Plasma
10
38
3.05
2.16
6.4
2.1
g/l
2.5
2.4
—
10
33
(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood
6
16
4.12
2.00
12.3
8.2
%
1.3
2.1
—
6
16
(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay
5
11
4.92
1.99
10.6
2.2
%
160.4
187.1
—
5
11
(3000330) Specific gravity of Urine by Test strip
5
11
4.92
1.99
4.0
2.5
—
—
—
0
0
(3030366) Cystatin C [Mass/volume] in Serum or Plasma
5
12
4.50
1.87
10.0
18.9
mg/l
1.3
1.1
—
5
12
(3042936) Bacteria identified in Isolate by Culture
12
55
2.57
1.85
2.0
1.5
—
—
—
0
0
(3044640) Blood type and Crossmatch panel - Blood
19
108
2.24
1.85
3.7
2.6
—
—
—
0
0
(42870588) Differential panel, method unspecified - Blood
20
117
2.20
1.81
6.2
8.2
—
—
—
0
0
(3003694) ABO and Rh group [Type] in Blood
17
94
2.24
1.76
1.5
1.4
—
—
—
0
0
(3022145) Colonoscopy Study observation
8
31
2.88
1.75
1.0
1.3
—
—
—
0
0
(36305247) Microscopic observation [Identifier] in Isolate by Gram stain
5
14
3.85
1.66
1.6
1.3
—
—
—
0
0
(40760892) CBC W Ordered Manual Differential panel - Blood
16
90
2.15
1.57
6.1
5.6
—
—
—
0
0
(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood
5
15
3.58
1.56
9.2
1.9
%
48.0
44.0
—
5
15
(3020961) Endomysium IgA Ab [Titer] in Serum
5
15
3.58
1.56
1.0
1.2
—
—
—
0
0
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
6
21
3.11
1.56
1.7
1.8
—
—
—
0
0
(4035726)
7
28
2.74
1.51
1.9
1.4
—
—
—
0
0
(3012544) pH of Venous blood
8
34
2.61
1.37
15.8
9.3
—
—
—
0
0
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
23
155
1.91
1.36
5.9
4.2
—
—
—
0
0
(3016293) Bicarbonate [Moles/volume] in Serum or Plasma
7
31
2.46
1.16
20.7
11.9
mmol/l
25.1
24.4
—
7
31
(3019225) pH of Specimen
5
21
2.53
1.12
5.4
5.7
—
—
—
0
0
(3041096) Erythrocytes [Presence] in Urine by Automated
16
102
1.84
1.08
2.9
2.9
—
—
—
0
0
(3018418) pH of Serum or Plasma
16
105
1.78
0.97
5.7
3.7
ph
7.4
7.4
—
5
24
(3036481) Cortisol [Moles/volume] in Serum or Plasma
6
27
2.39
0.97
4.2
2.1
nmol/l
390.2
382.3
—
6
22
(3037467) Urinalysis macro (dipstick) panel - Urine
31
246
1.71
0.96
3.8
3.9
—
—
—
0
0
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
8
42
2.08
0.94
8.9
2.8
—
—
—
0
0
(3002256) Pathology report gross observation
8
42
2.08
0.94
1.5
1.2
—
—
—
0
0
(3013512) EKG study
15
99
1.74
0.89
4.2
3.7
—
—
—
0
0
(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)
40
345
1.87
0.87
17.9
12.6
ml/min/173m2
82.6
83.0
0.04
35
291
(3020460) C reactive protein [Mass/volume] in Serum or Plasma
43
382
2.02
0.85
21.5
13.3
mg/l
20.1
23.0
0.26
36
285
(3019832) Treponema pallidum Ab [Presence] in Serum
0
24
0.00
0.81
0.0
1.4
—
—
—
0
0
(1761868) Lipid panel - Serum or Plasma
21
156
1.61
0.80
2.3
2.6
—
—
—
0
0
(3035350) Ketones [Presence] in Urine by Test strip
23
175
1.59
0.79
3.8
3.8
estimate
0.0
0.0
—
7
39
(36660697) Celiac disease serology panel - Serum
5
24
2.20
0.77
1.0
1.2
—
—
—
0
0
(40761511) CBC panel - Blood by Automated count
44
397
2.06
0.76
25.3
12.2
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
19
140
1.58
0.74
3.9
3.6
—
—
—
0
0
(40768804) Tissue Pathology biopsy report
19
140
1.58
0.74
2.1
2.0
—
—
—
0
0
(3007853) Bacteria identified in Skin by Aerobe culture
7
42
1.78
0.72
1.1
1.7
—
—
—
0
0
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
12
83
1.59
0.58
4.3
2.7
—
—
—
0
0
(3026008) Bacteria identified in Urine by Culture
14
101
1.54
0.58
3.4
2.5
—
—
—
0
0
(40761536) Microorganisms panel - Urine sediment
6
39
1.61
0.55
3.0
4.4
—
—
—
0
0
(3033319) Streptococcus pyogenes Ag [Presence] in Throat
6
39
1.61
0.55
1.2
1.3
—
—
—
0
0
(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma
7
49
1.50
0.48
1.1
1.7
—
—
—
0
0
(3023368) Bacteria identified in Blood by Culture
13
96
1.48
0.48
4.8
4.2
—
—
—
0
0
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
17
133
1.43
0.47
3.1
3.5
—
—
—
0
0
(3022313) Gas panel - Capillary blood
5
31
1.68
0.44
10.8
6.5
—
—
—
0
0
(3021589) Normoblasts [#/volume] in Blood
22
182
1.38
0.44
15.0
12.1
e9/l
0.0
0.1
0.60
16
155
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
8
60
1.40
0.43
1.3
2.1
—
—
—
0
0
(3000991) Gas panel - Venous blood
5
33
1.57
0.43
31.2
12.8
—
—
—
0
0
(3000494) Fungus identified in Specimen by Culture
6
44
1.41
0.36
1.2
1.5
—
—
—
0
0
(3009343) pH of Capillary blood
6
44
1.41
0.36
9.2
7.4
—
7.4
—
0
6
(3009542) Hematocrit [Volume Fraction] of Blood
39
361
1.39
0.33
21.7
14.3
%
41.1
40.0
0.50
27
269
(3021601) Nitrite [Presence] in Urine by Test strip
21
179
1.30
0.33
5.2
4.9
estimate
0.0
0.0
—
7
38
(3009261) Glucose [Presence] in Urine by Test strip
21
181
1.28
0.29
3.9
3.7
estimate
0.0
0.0
—
7
36
(3019150) Specific gravity of Urine by Refractometry
5
71
0.67
0.28
6.0
4.2
—
1.0
—
0
7
(3011397) Hemoglobin [Presence] in Urine by Test strip
6
81
0.70
0.26
6.0
4.3
—
—
—
0
0
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
5
39
1.31
0.23
1.2
1.9
—
—
—
0
0
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
5
41
1.24
0.23
1.4
1.9
—
—
—
0
0
(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma
5
42
1.21
0.22
11.8
5.5
—
—
—
0
0
(1616796) Gas panel - Central venous blood
0
11
0.00
0.21
0.0
3.9
—
—
—
0
0
(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection
0
11
0.00
0.21
0.0
2.1
—
—
—
0
0
(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma
0
10
0.00
0.21
0.0
4.4
—
89.7
—
0
10
(3024891) Influenza virus A+B Ag [Presence] in Specimen
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
(3050238) Crystals [Presence] in Synovial fluid by Light microscopy
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection
0
10
0.00
0.21
0.0
2.2
—
—
—
0
0
(3042111) Morphology [Interpretation] in Bone marrow Narrative
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
(3004959) Base excess in Arterial cord blood by calculation
0
12
0.00
0.21
0.0
1.0
—
-3.9
—
0
6
(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
(3041008) Bicarbonate [Moles/volume] standard in Arterial cord blood
0
12
0.00
0.21
0.0
1.0
—
19.3
—
0
12
(3006598) pH of Arterial cord blood
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
28
256
1.22
0.21
2.5
3.2
—
—
—
0
0
(3017895) Helicobacter pylori Ab [Units/volume] in Serum
0
13
0.00
0.21
0.0
1.8
—
—
—
0
0
(46235355) HIV 1 and 2 tests - Meaningful Use set
7
58
1.24
0.19
1.4
1.9
—
—
—
0
0
(3000850) Epithelial cells [#/volume] in Urine
10
83
1.26
0.17
1.8
2.4
e6/l
4.3
4.6
—
10
70
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
15
136
1.15
0.10
1.7
1.8
pmol/l
68.4
90.4
—
8
64
(3029937) Albumin [Presence] in Urine by Test strip
11
97
1.17
0.10
4.5
4.4
estimate
0.0
0.0
—
6
35
(3009201) Thyrotropin [Units/volume] in Serum or Plasma
34
337
1.03
0.00
4.5
4.2
mu/l
2.6
1.9
1.66
29
302
(3044889) 12 lead EKG panel
26
264
0.97
0.00
4.7
3.8
—
—
—
0
0
(36304419) Bacteria [Presence] in Urine
11
112
0.98
0.00
2.5
3.5
—
—
—
0
0
(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection
0
7
0.00
0.00
0.0
2.1
—
—
—
0
0
(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(36304997) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells [Units/volume] in Blood
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis
0
6
0.00
0.00
0.0
1.3
—
0.0
—
0
6
(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3027901) Hemoglobin [Mass/volume] in Arterial cord blood
0
7
0.00
0.00
0.0
1.0
—
170.9
—
0
7
(3023150) Myeloperoxidase Ab [Units/volume] in Serum
0
9
0.00
0.00
0.0
2.2
—
—
—
0
0
(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
2.0
—
1.0
—
0
5
(3012447) Hantavirus puumala IgG Ab [Titer] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3000081) cloZAPine [Moles/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
29.6
—
1130.2
—
0
5
(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
(3005229) Alpha 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
0
8
0.00
0.00
0.0
1.3
—
8.1
—
0
8
(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
(3023465) Gamma globulin [Mass/volume] in Serum or Plasma by Electrophoresis
0
8
0.00
0.00
0.0
1.3
—
10.0
—
0
8
(3005791) Eosinophil cationic protein (ECP) [Mass/volume] in Serum
0
5
0.00
0.00
0.0
1.2
—
17.4
—
0
5
(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection
0
9
0.00
0.00
0.0
2.2
—
—
—
0
0
(3044242) Glucose [Moles/volume] in Arterial blood
0
6
0.00
0.00
0.0
12.7
—
—
—
0
0
(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection
0
6
0.00
0.00
0.0
2.3
—
—
—
0
0
(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(3025018) Bordetella pertussis Ab [Titer] in Serum
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis
0
6
0.00
0.00
0.0
1.3
—
0.0
—
0
6
(3015322) Alpha 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
0
8
0.00
0.00
0.0
1.3
—
3.4
—
0
8
(3043747) Beta 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
0
8
0.00
0.00
0.0
1.3
—
3.7
—
0
8
(3044941) Cell count panel - Synovial fluid
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3045142) Bone marrow Pathology biopsy report
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(3047007) Chlamydophila sp Ab [Presence] in Serum
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3038177) Helicobacter pylori Ab [Presence] in Serum
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3008832) Norclozapine [Moles/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
21.0
—
790.0
—
0
5
(3002523) Influenza virus A Ag [Presence] in Specimen
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(3027544) Mycobacterium sp identified in Sputum by Organism specific culture
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
(3023420) DNA double strand Ab [Units/volume] in Serum
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(40758558) Short blood count panel - Blood
9
93
0.96
0.00
5.0
7.2
—
—
—
0
0
(3043109) Cytology report of Tissue fine needle aspirate Cyto stain
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
(3009466) Valproate [Moles/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
2.5
—
295.5
—
0
6
(3040151) Glucose [Moles/volume] in Capillary blood
0
5
0.00
0.00
0.0
1.4
—
5.2
—
0
5
(3013201) Beta-2-Microglobulin [Mass/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.6
—
5.4
—
0
5
(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection
0
6
0.00
0.00
0.0
2.3
—
—
—
0
0
(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis
0
6
0.00
0.00
0.0
1.3
—
0.0
—
0
6
(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3003740) Influenza virus B Ag [Presence] in Specimen
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(3051611) Lipemic interference index of Serum or Plasma
0
7
0.00
0.00
0.0
2.6
—
—
—
0
0
(3028286) Albumin [Mass/volume] in Serum or Plasma by Electrophoresis
0
8
0.00
0.00
0.0
1.3
—
37.6
—
0
8
(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_PORBILIRNAS and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have E4_PORBILIRNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: E4_PORBILIRNAS – Disorder of bilirubin metabolism, other/unspecified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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