Abuse of non-dependence-producing substances

F5_ABUNONDEP

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — F55 Cause of death: ICD-10 — F55 2 out of 7 registries used, show all original rules.	52
4. Check minimum number of events None	52
5. Include endpoints None	52
6. Filter based on genotype QC (FinnGen only)	48

Control definitions (FinnGen only)

Control exclude: F5_BEHAVE

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: F50-F59
Name in latin: Abusus substantiarum dependentiam non producentium

NAME	F5_ABUNONDEP
CONTROL_EXCLUDE	F5_BEHAVE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	F55
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	F55
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Abuse of non-dependence-producing substances based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	749	254	484
Only index persons	503	166	337
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	45.87	47.41	44.73
Only index persons	38.96	36.57	40.14

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	48	22	26
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	44.91	42.98	46.54

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
52: Matched controls
520

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

F55

ICD-10 Finland

Abuse of non-dependence-producing substances

+∞

74.4

F32.9

ICD-10 Finland

Depressive episode, unspecified

19.8

26.6

T36

ICD-10 Finland

Poisoning by systemic antibiotics

53.7

20.7

F10.1

ICD-10 Finland

Mental and behavioural disorders due to use of alcohol, Harmful use

30.3

20.3

X69

ICD-10 Finland

Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances

56.9

20.1

N06AX16

ATC

venlafaxine; oral

13.4

19.8

N06AB04

ATC

citalopram; systemic

13.0

19.6

N05AH04

ATC

quetiapine; oral

9.4

14.8

N06AX11

ATC

mirtazapine; oral

9.6

14.7

F51.0

ICD-10 Finland

Nonorganic insomnia

+∞

13.0

F33.9

ICD-10 Finland

Recurrent depressive disorder, unspecified

46.6

12.0

N05BA02

ATC

chlordiazepoxide; systemic

+∞

11.9

N05BA01

ATC

diazepam; systemic, rectal

8.4

11.8

N05AA02

ATC

levomepromazine; systemic

29.2

11.5

N05CF01

ATC

zopiclone; oral

6.6

10.7

N06AB06

ATC

sertraline; oral

11.3

10.2

AA1AD

NOMESCO Finland

CT of head and brain

6.4

10.0

F32.10

ICD-10 Finland

Moderate depressive episode without somatic syndrome

12.5

9.8

X44

ICD-10 Finland

Accidental poisoning by and exposure to other and unspecified drugs, medicaments and biological substances

121.2

9.8

N05BA04

ATC

oxazepam; oral

6.1

9.6

F10.25

ICD-10 Finland

Alcohol dependence continuous use

60.6

9.0

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

6.6

9.0

F10.21

ICD-10 Finland

Alcohol dependence currently abstinent, but staying in restrictive environment

106.7

8.7

N07BB01

ATC

disulfiram; oral

15.2

8.1

F60.30

ICD-10 Finland

Emotionally unstable personality disorder, impulsive

53.3

8.0

F10.26

ICD-10 Finland

Alcohol dependence periodic alcoholism

53.3

8.0

N05AH03

ATC

olanzapine; systemic

12.3

7.9

R11

ICD-10 Finland

Nausea and vomiting

10.6

7.8

F33.10

ICD-10 Finland

Recurrent depression, moderate episode without somatic syndrome

15.1

7.5

F10.09

ICD-10 Finland

Alcohol intoxication UNS

24.2

7.5

F10.00

ICD-10 Finland

Alcohol-related acute intoxication uncomplicated

24.2

7.5

N05AF03

ATC

chlorprothixene; systemic

35.5

7.4

F32.2

ICD-10 Finland

Severe depressive episode without psychotic symptoms

11.9

7.3

A06AD11

ATC

lactulose; oral

7.6

7.1

N05CD07

ATC

temazepam; oral

8.7

7.0

R56.8

ICD-10 Finland

Other and unspecified convulsions

12.6

7.0

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

4.5

6.7

P15

ICPC

Chronic alcohol abuse

13.5

6.7

N06AA06

ATC

trimipramine; systemic

79.2

6.6

N05BE01

ATC

buspirone; oral

30.8

6.4

F10.24

ICD-10 Finland

Alcohol depence active use

30.8

6.4

F10.29

ICD-10 Finland

Addiction caused by alcohol UNS

15.1

6.4

F41.9

ICD-10 Finland

Anxiety disorder, unspecified

7.9

6.2

R55

ICD-10 Finland

Syncope and collapse

8.7

6.2

F33.2

ICD-10 Finland

Recurrent depressive disorder, current episode severe without psychotic symptoms

11.3

6.1

Z00.4

ICD-10 Finland

General psychiatric examination, not elsewhere classified

7.1

6.1

N06AX21

ATC

duloxetine; oral

7.6

6.1

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3011288) Drugs identified in Urine by Screen method

12.28

7.89

19.7

1.4

—

(3028707) Methadone [Presence] in Urine by Screen method

12.87

7.55

17.4

1.9

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

8.70

6.98

20.3

1.7

—

(3028300) Cannabinoids [Presence] in Urine

7.21

6.53

19.3

1.6

—

(3016879) Cocaine [Presence] in Urine

7.35

6.29

20.3

1.7

—

(3000764) Benzodiazepines [Presence] in Urine

7.08

6.13

20.5

1.7

—

(3027944) Amphetamines [Presence] in Urine

7.08

6.13

20.9

1.6

—

(3027008) Opiates [Presence] in Urine

6.82

5.98

6.3

1.6

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

165

3.44

4.50

10.2

7.9

1.18

1.21

mmol/l

1.14

143

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

6.60

4.22

2.5

4.3

23.79

25.33

mmol/l

—

(3023183) Ammonium ion [Moles/volume] in Plasma

8.76

3.68

3.0

2.6

33.71

39.22

umol/l

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

3.54

3.52

5.2

7.3

103.29

105.31

mmol/l

0.71

(3000991) Gas panel - Venous blood

4.36

3.33

5.8

5.6

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

4.33

3.07

3.8

3.7

4.73

5.03

kpa

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

5.35

3.05

4.0

2.7

2.81

1.57

—

(3015235) Bicarbonate [Moles/volume] in Capillary blood

7.35

2.95

3.0

2.4

23.30

25.02

mmol/l

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

4.53

2.69

5.3

2.7

131.63

122.80

g/l

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

220

2.58

2.64

9.2

4.4

6.42

6.70

mmol/l

0.33

206

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

2.63

2.47

1.8

2.0

—

(3018405) Lactate [Moles/volume] in Arterial blood

4.58

2.45

3.0

7.8

1.43

1.16

mmol/l

—

(3019060) Gas panel - Arterial blood

3.66

2.44

9.1

4.0

—

(3012544) pH of Venous blood

3.39

2.44

3.8

2.3

—

(3026008) Bacteria identified in Urine by Culture

2.51

2.40

4.5

2.9

—

(3044640) Blood type and Crossmatch panel - Blood

122

2.39

2.32

2.2

2.0

—

(3022217) INR in Platelet poor plasma by Coagulation assay

165

2.32

2.27

20.7

9.3

1.41

1.21

inr

0.31

(3026782) Osmolality of Urine

2.56

2.18

3.9

2.8

479.00

538.98

mosm/kgh2o

—

(3022313) Gas panel - Capillary blood

3.87

2.14

3.6

3.8

—

(3023511) Choriogonadotropin [Units/volume] in Urine

5.40

2.12

1.8

1.2

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

3.68

2.04

1.6

1.4

—

(3043409) Potassium [Moles/volume] in Arterial blood

4.09

2.00

3.2

4.0

3.78

3.93

mmol/l

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

4.09

2.00

3.7

2.7

0.68

0.76

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

4.90

1.99

2.0

2.2

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

4.48

1.87

1.8

1.3

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

132

2.16

1.86

6.4

3.6

33.76

31.74

u/l

0.14

125

(3020891) Body temperature

3.62

1.80

6.5

5.1

—

(3014007) Fractional oxyhemoglobin in Arterial blood

3.20

1.79

4.0

7.2

91.91

93.32

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.33

1.74

1.8

1.9

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

3.07

1.72

4.4

7.0

2.91

1.73

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

3.07

1.72

4.4

7.0

1.01

0.69

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

3.83

1.65

2.4

1.2

—

(1761868) Lipid panel - Serum or Plasma

159

0.41

1.61

2.8

2.4

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.68

1.61

1.5

1.8

—

(3013512) EKG study

2.12

1.55

6.7

3.9

—

(3026361) Erythrocytes [#/volume] in Blood

481

0.39

1.52

37.2

17.5

4.53

4.61

e12/l

0.38

466

(3024731) MCV [Entitic volume]

481

0.39

1.52

37.0

17.4

89.86

90.49

0.22

469

(3035941) MCH [Entitic mass]

481

0.39

1.52

37.0

17.4

29.84

30.23

0.40

469

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.94

1.48

1.2

1.5

—

(3013115) Eosinophils [#/volume] in Blood

190

1.88

1.37

8.0

6.5

0.14

0.18

e9/l

0.89

167

(3019225) pH of Specimen

2.51

1.34

4.7

5.5

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

2.80

1.24

7.4

3.3

27.46

24.31

mmol/l

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.80

1.24

14.2

6.7

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

226

1.77

1.16

7.4

9.3

5.71

4.20

e9/l

0.96

194

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

143

1.79

1.14

4.9

3.1

—

(3041096) Erythrocytes [Presence] in Urine by Automated

100

1.87

1.14

3.7

3.3

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.37

1.13

3.0

4.2

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.21

1.12

1.4

1.7

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.52

1.11

2.6

2.3

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.52

1.11

2.6

1.8

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

311

0.58

1.10

4.3

3.1

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.10

1.09

1.4

1.6

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

146

1.74

1.05

7.4

3.8

17.84

37.10

ng/l

1.95

(3022145) Colonoscopy Study observation

2.15

1.04

1.3

1.2

—

(40761511) CBC panel - Blood by Automated count

449

0.53

0.99

24.1

11.4

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.99

0.0

1.5

—

(3001604) Monocytes [#/volume] in Blood

186

1.66

0.96

6.2

6.1

0.62

0.58

e9/l

0.28

164

(3006315) Basophils [#/volume] in Blood

186

1.66

0.96

6.3

6.1

0.03

0.04

e9/l

0.25

165

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

415

0.57

0.96

4.7

4.2

2.67

2.78

mmol/l

0.30

379

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

306

1.73

0.94

7.4

2.8

69.44

45.29

u/l

0.86

290

(3023368) Bacteria identified in Blood by Culture

106

1.74

0.93

5.7

4.7

—

(3018095) Leukocytes [#/volume] in Urine

142

1.66

0.91

6.7

3.1

47.36

80.03

e6/l

0.27

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.13

0.90

2.2

1.5

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

136

1.63

0.83

3.0

1.9

87.48

94.10

pmol/l

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.92

0.82

2.2

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

0.00

0.81

0.0

1.2

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.00

0.81

0.0

1.5

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.80

0.80

1.4

1.2

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

408

0.62

0.75

4.2

3.8

4.45

4.64

mmol/l

0.51

373

(40768797) Stomach Pathology biopsy report

1.86

0.75

1.1

1.2

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

140

1.56

0.72

8.4

4.0

—

(40760892) CBC W Ordered Manual Differential panel - Blood

179

1.51

0.68

7.3

6.2

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.73

0.67

1.9

1.6

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

182

1.47

0.62

2.3

2.2

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.62

0.0

1.6

—

(36660697) Celiac disease serology panel - Serum

1.86

0.61

1.2

—

(3037467) Urinalysis macro (dipstick) panel - Urine

251

1.46

0.60

6.0

3.8

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

1.54

0.57

1.9

2.3

2.66

2.36

g/l

—

(3019069) Monocytes/100 leukocytes in Blood

175

1.45

0.57

12.1

6.1

7.39

8.29

0.61

167

(40758558) Short blood count panel - Blood

1.53

0.55

6.2

7.0

—

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

1.62

0.43

1.4

1.1

—

119.41

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

0.00

0.42

0.0

1.1

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

0.00

0.42

0.0

1.1

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.42

0.0

1.3

—

(3045414) Leukocytes [Presence] in Urine

0.00

0.42

0.0

1.4

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.41

0.0

1.5

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.41

0.0

1.5

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.41

0.0

1.5

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.41

0.0

1.5

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.41

0.0

1.5

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.41

0.0

1.5

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.40

0.0

1.6

—

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

0.00

0.40

0.0

1.6

—

2.35

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.47

0.40

1.0

2.3

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

0.66

0.37

3.2

1.5

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

1.40

0.36

1.4

1.6

1.30

1.44

mmol/l

0.39

(3000494) Fungus identified in Specimen by Culture

1.38

0.35

1.2

1.4

—

(3030467) Casts [#/volume] in Urine by Automated count

111

1.36

0.34

3.3

2.8

0.06

0.57

e6/l

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

111

1.36

0.34

3.1

1.8

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.34

0.34

5.3

7.5

—

(3042936) Bacteria identified in Isolate by Culture

1.37

0.30

1.0

2.3

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.29

0.29

2.8

2.0

—

(3007566) Smooth muscle Ab [Titer] in Serum

0.00

0.21

0.0

1.1

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.21

0.0

1.4

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.21

0.0

1.7

—

(3034770) Mitochondria Ab [Titer] in Serum

0.00

0.21

0.0

1.1

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.21

0.0

1.7

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.21

0.0

2.2

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

0.00

0.21

0.0

1.9

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.5

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.2

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.2

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.21

0.0

1.5

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.20

0.0

1.8

—

(3003694) ABO and Rh group [Type] in Blood

130

0.80

0.18

1.3

—

(36304419) Bacteria [Presence] in Urine

111

1.23

0.18

3.3

2.6

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.15

0.17

3.0

2.1

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

413

1.24

0.14

30.7

13.9

3.96

mmol/l

0.00

400

(3044889) 12 lead EKG panel

251

1.16

0.14

5.2

3.4

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

0.79

0.08

1.8

3.3

2.47

2.45

mmol/l

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.04

0.07

12.2

3.8

—

(40768804) Tissue Pathology biopsy report

150

1.10

0.05

1.4

2.0

—

(3002385) Erythrocyte distribution width [Ratio]

369

0.92

0.04

28.3

14.7

15.77

14.26

0.84

363

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

384

0.96

0.00

22.9

11.3

89.45

88.43

ml/min/173m2

0.09

312

(1616796) Gas panel - Central venous blood

0.00

0.0

2.4

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.2

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.7

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.0

1.7

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.0

1.7

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.0

1.3

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.0

—

(3028167) CD3+CD4+ (T4 helper) cells [#/volume] in Blood

0.00

0.0

2.7

—

513.67

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.7

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.7

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.7

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.0

1.7

—

(3034274) Bile acid [Moles/volume] in Serum --fasting

0.00

0.0

2.9

—

3.40

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.0

1.7

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.7

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.7

—

(40760888) Immunoglobulin light chains.free panel - Serum

0.00

0.0

6.0

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.0

2.8

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(4146454) Self-monitoring of blood glucose

0.00

0.0

4.6

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.0

1.7

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.0

1.4

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.0

1.7

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.0

1.5

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(42529406) Shigella sp [Presence] in Stool by Culture

0.00

-0.00

0.0

1.7

—

(4062490) Immunoglobulin typing, IgG

0.00

-0.00

0.0

1.0

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(46235689) Lupus anticoagulant aPTT, dRVVT and PT screening panel W Reflex

0.00

-0.00

0.0

2.0

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3044355) Beta 2 glycoprotein 1 IgG Ab [Units/volume] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

1.2

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

2.1

—

4.30

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(3042631) Mycobacterium sp identified in Specimen

0.00

-0.00

0.0

6.2

—

(3006922) Hepatitis E virus Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

0.00

-0.00

0.0

1.6

—

(4094501) Cardiovascular stress test using bicycle ergometer

0.00

-0.00

0.0

1.0

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(3023419) Bacteria identified in Sputum by Culture

0.00

-0.00

0.0

2.6

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

-0.00

0.0

1.2

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.2

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

-0.00

0.0

2.4

—

(3012110) Lysozyme [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

14.50

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3043453) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3020629) Protein S Free Ag actual/normal in Platelet poor plasma by Immunoassay

0.00

-0.00

0.0

1.2

—

90.40

—

(40768795) Lymph node Pathology biopsy report

0.00

-0.00

0.0

1.0

—

(3017315) Amylase [Enzymatic activity/volume] in Urine

0.00

-0.00

0.0

1.4

—

419.40

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

-0.00

0.0

1.2

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

-0.00

0.0

2.0

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

-0.00

0.0

1.0

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.01

-0.00

1.6

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

0.00

-0.00

0.0

1.6

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

-0.00

0.0

1.2

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3029634) Reagin Ab [Titer] in Serum by VDRL

0.00

-0.00

0.0

2.4

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.6

—

1.50

—

Mortality – FinRegistry

↥

Association

Association between endpoint F5_ABUNONDEP and mortality.

Females

No data

Males

Parameter	HR [95% CI]	p-value
F5_ABUNONDEP	4.878 [3.14, 7.57]	< 0.001
Birth year	0.987 [0.98, 1.0]	0.009

During the follow-up period (1.1.1998 — 31.12.2019), 97 out of 279 males with F5_ABUNONDEP died.

Mortality risk

Mortality risk for people of age

years, who have F5_ABUNONDEP.

N-year risk	Females	Males
1	No data	0.902%
5	No data	5.273%
10	No data	12.758%
15	No data	24.307%
20	No data	38.78%

Relationships between endpoints

↥

Index endpoint: F5_ABUNONDEP – Abuse of non-dependence-producing substances

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Abuse of non-dependence-producing substances

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints