Abuse of non-dependence-producing substances

F5_ABUNONDEP

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — F55 Cause of death: ICD-10 — F55 2 out of 7 registries used, show all original rules.	48
4. Check minimum number of events None	48
5. Include endpoints None	48
6. Filter based on genotype QC (FinnGen only)	48

Control definitions (FinnGen only)

Control exclude: F5_BEHAVE

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: F50-F59
Name in latin: Abusus substantiarum dependentiam non producentium

NAME	F5_ABUNONDEP
CONTROL_EXCLUDE	F5_BEHAVE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	F55
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	F55
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Abuse of non-dependence-producing substances based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	749	254	484
Only index persons	503	166	337
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	45.87	47.41	44.73
Only index persons	38.96	36.57	40.14

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	48	22	26
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	45.99	42.98	48.54

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3011288) Drugs identified in Urine by Screen method

14.21

11.52

22.8

1.3

—

(3028707) Methadone [Presence] in Urine by Screen method

12.68

9.92

20.4

1.9

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

9.53

9.34

23.2

1.8

—

(3028300) Cannabinoids [Presence] in Urine

8.57

9.09

21.9

1.6

—

(3016879) Cocaine [Presence] in Urine

8.54

8.55

23.2

1.7

—

(3000764) Benzodiazepines [Presence] in Urine

8.12

8.19

23.5

1.7

—

(3027944) Amphetamines [Presence] in Urine

8.12

8.19

24.0

1.6

—

(3027008) Opiates [Presence] in Urine

7.73

7.85

7.2

1.6

—

(3042517) Benzodiazepines panel - Urine

+∞

5.29

4.6

0.0

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

3.52

4.29

4.6

2.3

205.6

181.6

u/l

0.15

(3023183) Ammonium ion [Moles/volume] in Plasma

13.42

3.87

3.3

3.0

34.8

40.8

umol/l

—

(3026008) Bacteria identified in Urine by Culture

2.76

2.75

4.5

2.8

—

(3019060) Gas panel - Arterial blood

4.18

2.74

9.1

3.3

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

4.93

2.58

1.9

4.9

25.0

25.5

mmol/l

—

(3018405) Lactate [Moles/volume] in Arterial blood

4.93

2.58

3.0

6.6

1.4

1.1

mmol/l

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

4.93

2.58

4.4

3.3

2.3

1.1

—

(3000991) Gas panel - Venous blood

3.86

2.55

5.7

6.3

—

(3022313) Gas panel - Capillary blood

4.63

2.46

3.6

3.1

—

(3012544) pH of Venous blood

3.58

2.37

4.0

2.7

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

4.36

2.35

5.9

3.2

132.4

122.5

g/l

—

(3023511) Choriogonadotropin [Units/volume] in Urine

5.43

2.12

1.8

1.4

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

209

2.36

2.08

9.7

4.4

6.4

6.7

mmol/l

0.29

194

(3044640) Blood type and Crossmatch panel - Blood

120

2.33

2.07

2.2

2.0

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

4.93

1.99

2.0

2.2

—

(3019225) pH of Specimen

3.22

1.96

4.7

5.7

—

(3026782) Osmolality of Urine

2.49

1.94

3.9

2.4

432.1

561.1

mosm/kgh2o

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

2.39

1.93

1.7

1.9

—

(3020891) Body temperature

3.88

1.90

6.5

3.6

—

(3035941) MCH [Entitic mass]

450

0.33

1.82

38.0

17.8

29.8

30.3

0.49

440

(3026361) Erythrocytes [#/volume] in Blood

450

0.33

1.82

38.3

17.9

4.5

4.6

e12/l

0.35

437

(3024731) MCV [Entitic volume]

450

0.33

1.82

38.0

17.8

89.8

90.7

0.34

440

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.46

1.80

1.8

2.0

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

4.16

1.76

2.4

1.2

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

3.27

1.64

1.7

1.4

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

3.59

1.56

4.2

3.3

0.8

0.7

—

(3000850) Epithelial cells [#/volume] in Urine

2.17

1.53

2.4

2.5

5.9

e6/l

—

(3013512) EKG study

2.17

1.53

6.9

3.8

—

(3014007) Fractional oxyhemoglobin in Arterial blood

2.83

1.41

3.0

6.4

91.7

93.3

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

3.16

1.39

7.4

3.4

27.5

24.9

mmol/l

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

3.16

1.39

14.2

7.4

—

(1761868) Lipid panel - Serum or Plasma

140

0.42

1.38

3.0

2.4

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

288

0.52

1.37

4.4

3.3

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

2.71

1.35

3.5

6.1

1.0

0.7

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

2.71

1.35

3.5

6.2

3.3

1.5

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.98

1.32

2.6

1.7

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.98

1.32

2.6

2.3

—

(3041096) Erythrocytes [Presence] in Urine by Automated

2.02

1.30

3.9

3.4

—

(3032080) INR in Blood by Coagulation assay

131

1.90

1.27

12.0

6.5

1.6

1.2

inr

—

(3015736) pH of Urine

140

1.89

1.27

7.6

3.7

—

(40761511) CBC panel - Blood by Automated count

421

0.47

1.19

25.4

11.1

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

389

0.51

1.18

4.9

4.1

2.7

2.8

mmol/l

0.18

356

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.67

1.18

1.2

1.5

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.14

1.15

1.5

1.8

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.39

1.13

1.4

1.7

—

(3022145) Colonoscopy Study observation

2.24

1.08

1.3

—

(3013115) Eosinophils [#/volume] in Blood

185

1.73

1.03

8.4

6.7

0.1

0.2

e9/l

0.76

164

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

139

1.75

1.02

5.2

3.0

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

139

1.75

1.02

7.5

3.8

18.2

35.8

ng/l

1.58

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

276

1.80

0.99

7.6

2.7

60.1

44.8

u/l

0.54

259

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.99

0.0

1.4

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

123

1.74

0.96

3.1

1.8

87.0

91.9

pmol/l

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.03

0.93

1.5

1.6

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.22

0.93

2.2

1.6

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

382

0.56

0.93

4.4

3.7

4.5

4.6

mmol/l

0.24

349

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.07

0.88

3.2

3.9

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.86

0.81

1.4

1.3

—

(3018095) Leukocytes [#/volume] in Urine

138

1.62

0.79

7.0

3.4

50.7

66.1

e6/l

0.12

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

129

1.63

0.79

8.8

4.1

—

(40768797) Stomach Pathology biopsy report

1.83

0.74

1.1

1.2

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.77

0.72

1.9

1.6

—

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

1.95

0.70

1.4

1.1

—

131.0

—

(3037467) Urinalysis macro (dipstick) panel - Urine

240

1.53

0.66

6.1

3.9

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

1.61

0.62

2.0

2.3

2.7

2.3

g/l

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.62

0.0

1.6

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.61

0.0

1.6

—

(36660697) Celiac disease serology panel - Serum

1.87

0.61

1.2

1.1

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

0.00

0.61

0.0

1.1

—

(3023368) Bacteria identified in Blood by Culture

100

1.56

0.60

5.5

4.6

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.00

0.60

0.0

1.6

—

(3009542) Hematocrit [Volume Fraction] of Blood

379

0.65

0.58

21.9

12.0

40.7

41.0

0.15

302

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

176

1.46

0.56

3.4

3.8

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.61

0.55

2.2

2.3

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

0.56

0.51

3.6

1.5

—

(40760892) CBC W Ordered Manual Differential panel - Blood

1.51

0.48

3.2

6.3

—

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

0.00

0.42

0.0

1.7

—

5.4

—

(3045414) Leukocytes [Presence] in Urine

0.00

0.41

0.0

1.7

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.40

0.0

1.5

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.40

0.0

1.5

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.40

0.0

1.5

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.40

0.0

1.5

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.40

0.0

1.5

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.40

0.0

1.5

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.40

0.0

1.3

—

(3019069) Monocytes/100 leukocytes in Blood

167

1.34

0.37

13.1

6.4

7.5

8.4

0.61

159

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.45

0.37

5.3

7.1

—

(3000494) Fungus identified in Specimen by Culture

1.45

0.37

1.2

1.3

—

(40758558) Short blood count panel - Blood

1.41

0.36

6.3

6.4

—

(3042936) Bacteria identified in Isolate by Culture

1.32

0.31

1.0

2.4

—

(3003694) ABO and Rh group [Type] in Blood

126

0.74

0.28

1.2

1.4

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

0.67

0.28

2.0

3.4

2.4

2.5

mmol/l

—

(3002385) Erythrocyte distribution width [Ratio]

336

0.78

0.27

29.3

15.2

14.4

13.4

1.76

330

(3007853) Bacteria identified in Skin by Aerobe culture

1.35

0.24

1.0

2.1

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.3

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.21

0.0

2.1

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.21

0.0

1.0

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.21

0.0

1.4

—

(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum

0.00

0.21

0.0

4.0

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

0.00

0.21

0.0

1.7

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.21

0.0

1.7

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.21

0.0

1.7

—

(3030467) Casts [#/volume] in Urine by Automated count

109

1.26

0.21

3.5

3.0

0.1

0.4

e6/l

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

0.00

0.21

0.0

1.2

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.20

0.0

1.9

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

1.26

0.17

1.5

1.6

1.3

1.5

mmol/l

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

386

1.22

0.15

31.3

14.5

3.9

4.0

mmol/l

0.04

374

(46235355) HIV 1 and 2 tests - Meaningful Use set

107

1.16

0.09

3.1

1.9

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.13

0.08

3.0

2.0

—

(36304419) Bacteria [Presence] in Urine

108

1.15

0.08

3.5

2.8

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

362

0.88

0.08

23.3

11.8

88.8

88.6

ml/min/173m2

0.02

292

(3011397) Hemoglobin [Presence] in Urine by Test strip

0.89

0.07

12.2

3.5

—

(42870588) Differential panel, method unspecified - Blood

112

1.10

0.03

10.4

5.2

—

(40768804) Tissue Pathology biopsy report

145

0.95

0.00

1.4

1.8

—

(3044889) 12 lead EKG panel

237

1.03

0.00

5.7

3.4

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.0

2.6

—

(3034274) Bile acid [Moles/volume] in Serum --fasting

0.00

0.0

3.2

—

3.8

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.0

1.4

—

(3042631) Mycobacterium sp identified in Specimen

0.00

0.0

6.2

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.0

1.2

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.0

2.4

—

5.1

—

(3005136) Cladosporium herbarum IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

0.00

0.0

1.8

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

0.0

7.7

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.0

—

(1616796) Gas panel - Central venous blood

0.00

0.0

1.7

—

(4146454)

0.00

0.0

4.2

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.7

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3007566) Smooth muscle Ab [Titer] in Serum

0.00

0.0

1.2

—

(3001405) CD3+CD8+ (T8 suppressor) cells [#/volume] in Blood

0.00

0.0

1.4

—

727.8

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(42529201) Cancer Ag 19-9 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

4.0

—

7.7

—

(3034770) Mitochondria Ab [Titer] in Serum

0.00

0.0

1.2

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(4094501)

0.00

0.0

1.0

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3029634) Reagin Ab [Titer] in Serum by VDRL

0.00

0.0

2.8

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.0

1.1

—

(40760888) Immunoglobulin light chains.free panel - Serum

0.00

0.0

6.0

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.0

1.8

—

(3025271) CD3-CD16+CD56+ (Natural killer) cells [#/volume] in Blood

0.00

0.0

1.4

—

0.2

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.0

2.3

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

0.00

0.0

1.8

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.00

0.00

3.3

2.2

—

(42529406) Shigella sp [Presence] in Stool by Culture

0.00

0.0

1.8

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.0

2.0

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.7

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.7

—

(3023420) DNA double strand Ab [Units/volume] in Serum

0.00

0.0

1.6

—

(3024980) IgG subclass 4 [Mass/volume] in Serum

0.00

0.0

1.4

—

1.2

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

0.92

0.00

1.5

1.6

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.0

1.7

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.0

1.3

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.0

1.7

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.7

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.7

—

(3043453) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum

0.00

0.0

1.2

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.0

1.7

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.0

1.7

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.2

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.7

—

(3012110) Lysozyme [Mass/volume] in Serum or Plasma

0.00

0.0

1.3

—

17.5

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

0.0

2.6

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.0

1.7

—

Mortality – FinRegistry

↥

Association

Association between endpoint F5_ABUNONDEP and mortality.

Females

No data

Males

Parameter	HR [95% CI]	p-value
F5_ABUNONDEP	4.878 [3.14, 7.57]	< 0.001
Birth year	0.987 [0.98, 1.0]	0.009

During the follow-up period (1.1.1998 — 31.12.2019), 97 out of 279 males with F5_ABUNONDEP died.

Mortality risk

Mortality risk for people of age

years, who have F5_ABUNONDEP.

N-year risk	Females	Males
1	No data	0.902%
5	No data	5.273%
10	No data	12.758%
15	No data	24.307%
20	No data	38.78%

Relationships between endpoints

↥

Index endpoint: F5_ABUNONDEP – Abuse of non-dependence-producing substances

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Abuse of non-dependence-producing substances

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints