lacrimal apparatus disease: A non-neoplastic or neoplastic disorder that affects the lacrimal apparatus. [ NCIT:C26809 ]
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
74 |
4. Check minimum number of eventsNone |
74 |
5. Include endpointsNone |
74 |
6. Filter based on genotype QC (FinnGen only) |
69 |
Control definitions (FinnGen only)
- Control exclude
- H7_LIDLACRIMALORBIT
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified disorders of lacrimal system
based on the number of shared cases.
Similar with more cases:
- Disorders of lacrimal system
- Disorders of eyelid, lacrimal system and orbit
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 803 | 490 | 308 |
| Only index persons | 648 | 405 | 243 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 44.27 | 48.86 | 36.91 |
| Only index persons | 40.49 | 46.01 | 31.31 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 69 | 44 | 25 |
| Unadjusted period prevalence (%) | 0.01 | 0.02 | 0.01 |
| Median age at first event (years) | 41.15 | 44.25 | 35.70 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 74
- Matched controls
- 740
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H04.9
ICD-10 Finland
Disorder of lacrimal system, unspecified
+∞
32.7
29
*
36809
ICD-8 Finland
Inflammation of lachrymal glands and ducts, Unspecified
+∞
17.4
16
*
H04.8
ICD-10 Finland
Other disorders of lacrimal system
+∞
17.4
16
*
H04.5
ICD-10 Finland
Stenosis and insufficiency of lacrimal passages
127.3
10.7
11
*
36808
ICD-8 Finland
Inflammation of lachrymal glands and ducts, Alii definiti
+∞
10.7
10
*
XCC00
NOMESCO Finland
Investigative irrigation of lacrimal passages
+∞
7.4
7
*
TCC10
NOMESCO Finland
Probing of lacrimal canaliculus/duct
+∞
7.4
7
*
H04.10
ICD-10 Finland
Dry eye syndrome
8.7
7.1
15
21
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
8
10
8.80
4.17
6.4
1.1
93.88
98.30
%
—
8
10
6
9
7.13
2.92
8.5
1.4
234.67
196.78
%
—
6
9
5
7
7.55
2.59
1.2
1.3
—
—
—
0
0
7
16
4.71
2.54
2.1
1.3
—
—
—
0
0
6
12
5.33
2.45
2.8
1.5
1.14
1.19
g/l
—
6
12
6
12
5.33
2.45
2.8
1.5
0.27
0.25
g/l
—
6
12
5
9
5.86
2.25
1.6
1.4
—
—
—
0
0
40
274
2.00
2.22
7.5
4.3
0.00
0.00
estimate
—
9
56
14
63
2.51
2.17
4.6
5.7
104.07
103.38
mmol/l
0.23
14
63
40
277
1.97
2.12
6.4
3.4
0.00
0.00
estimate
—
9
51
6
17
3.74
1.88
1.3
1.3
—
—
—
0
0
6
17
3.74
1.88
1.2
1.1
—
—
—
0
0
7
25
2.98
1.69
22.7
3.6
23.96
24.34
mmol/l
—
7
25
15
79
2.13
1.64
5.5
2.6
0.60
1.29
e6/l
—
10
38
9
37
2.63
1.54
2.0
5.7
0.79
0.73
%
—
9
37
9
37
2.63
1.54
1.4
1.6
—
—
—
0
0
9
37
2.63
1.54
2.0
5.7
1.72
1.46
%
—
9
37
38
280
1.73
1.50
6.4
3.3
0.00
0.00
estimate
-0.00
11
60
33
246
1.62
1.18
6.0
3.7
35.95
35.90
g/l
0.01
33
234
30
219
1.62
1.16
3.3
4.1
25.89
31.33
ng/l
0.31
22
147
27
193
1.63
1.13
4.7
2.8
—
—
—
0
0
12
68
1.91
1.08
2.1
1.6
—
—
—
0
0
12
68
1.91
1.08
1.9
1.5
—
—
—
0
0
34
263
1.54
1.00
21.0
14.6
1.62
1.25
inr
0.86
13
79
6
29
2.16
0.91
1.7
3.3
0.60
0.09
e6/l
—
6
29
46
388
1.49
0.86
4.2
3.4
—
—
—
0
0
5
24
2.16
0.76
1.4
1.5
—
—
—
0
0
21
158
1.46
0.67
9.0
3.6
0.00
0.00
estimate
—
9
58
16
115
1.50
0.63
1.2
1.6
—
—
—
0
0
5
30
1.71
0.62
1.6
1.5
—
—
—
0
0
9
62
1.51
0.56
2.9
3.1
—
—
—
0
0
14
102
1.46
0.52
2.1
1.9
—
—
—
0
0
27
223
1.33
0.50
7.8
3.3
—
—
—
0
0
7
48
1.51
0.48
2.6
2.9
8.86
3.47
ug/l
—
7
43
53
483
1.34
0.48
3.8
3.9
15.15
14.78
pmol/l
0.63
46
443
5
31
1.66
0.44
2.0
1.3
—
—
—
0
0
17
133
1.36
0.43
4.5
1.8
—
—
—
0
0
19
155
1.30
0.37
2.6
3.7
11.03
10.18
mg/mmol
0.04
12
94
10
73
1.43
0.37
6.3
2.6
0.20
2.76
e6/l
—
5
32
8
63
1.30
0.29
1.9
2.3
—
—
—
0
0
8
64
1.28
0.28
10.3
7.5
—
—
—
0
0
59
565
1.22
0.22
13.7
12.3
80.21
82.18
ml/min/173m2
0.27
50
458
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
2.2
—
—
—
0
0
0
10
0.00
0.21
0.0
2.9
—
36.17
—
0
10
0
10
0.00
0.21
0.0
1.4
—
20.23
—
0
10
12
99
1.25
0.21
6.9
4.9
13.62
19.61
%
—
6
53
8
69
1.18
0.17
10.6
3.3
1.14
1.05
mmol/l
—
8
62
8
71
1.14
0.17
2.8
2.5
—
—
—
0
0
31
289
1.13
0.14
3.6
2.2
—
—
—
0
0
13
142
0.90
0.07
1.7
1.3
0.42
1.06
u/ml
—
5
34
61
620
0.91
0.05
23.3
14.7
3.97
3.98
mmol/l
0.12
61
606
61
618
0.93
0.03
23.1
14.7
139.05
139.61
mmol/l
1.04
61
604
22
225
0.97
0.00
1.5
1.8
105.36
93.98
pmol/l
0.62
11
107
57
571
0.99
0.00
4.8
4.3
5.77
5.80
mmol/l
0.11
52
527
57
569
1.01
0.00
5.0
4.6
2.15
1.88
mu/l
0.34
52
526
17
174
0.97
0.00
2.9
2.1
152.18
249.85
u/l
0.42
17
165
9
93
0.96
0.00
2.2
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
68
678
1.04
-0.00
29.9
19.2
133.84
134.58
g/l
0.16
68
673
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
1.67
—
0
6
0
5
0.00
-0.00
0.0
2.6
—
229.00
—
0
5
65
645
1.06
-0.00
21.7
14.8
80.26
75.01
umol/l
0.49
65
645
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_LACRINAS and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have H7_LACRINAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: H7_LACRINAS – Other and unspecified disorders of lacrimal system
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data