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Other and unspecified disorders of lacrimal system

DOID EFO Endpoint Browser PheWeb

H7_LACRINAS

lacrimal apparatus disease: A non-neoplastic or neoplastic disorder that affects the lacrimal apparatus. [ NCIT:C26809 ]

Suggest a new description

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H04.8, H04.9
  • Hospital discharge: ICD-9 — 375[8-9]
  • Hospital discharge: ICD-8 — 3680[8-9]
  • Cause of death: ICD-10 — H04.8, H04.9
  • Cause of death: ICD-9 — 375[8-9]
  • Cause of death: ICD-8 — 3680[8-9]

2 out of 7 registries used, show all original rules.

71

4. Check minimum number of events

None

71

5. Include endpoints

None

71

6. Filter based on genotype QC (FinnGen only)

71

Control definitions (FinnGen only)

Control exclude
H7_LIDLACRIMALORBIT

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 803 490 308
Only index persons 648 405 243
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 44.27 48.86 36.91
Only index persons 40.49 46.01 31.31

-FinnGen-

Key figures

All Female Male
Number of individuals 71 47 24
Unadjusted period prevalence (%) 0.01 0.02 0.01
Median age at first event (years) 41.50 44.74 35.16

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
64
Matched controls
638
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H04.9
ICD-10 Finland
Disorder of lacrimal system, unspecified
+∞
24.5
22
*
36809
ICD-8 Finland
Inflammation of lachrymal glands and ducts, Unspecified
+∞
17.5
16
*
H04.8
ICD-10 Finland
Other disorders of lacrimal system
+∞
14.0
13
*
36808
ICD-8 Finland
Inflammation of lachrymal glands and ducts, Alii definiti
+∞
10.7
10
*
H04.5
ICD-10 Finland
Stenosis and insufficiency of lacrimal passages
+∞
10.7
10
*
H04.10
ICD-10 Finland
Dry eye syndrome
29.9
6.4
8
*

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
14
39
4.23
4.76
12.9
3.0
—
—
—
0
0
33
170
2.76
4.17
4.7
2.8
—
—
—
0
0
9
22
4.52
3.00
3.0
3.1
—
—
—
0
0
7
13
5.84
2.94
2.7
3.5
—
—
—
0
0
11
38
3.24
2.72
2.9
2.6
—
—
—
0
0
45
320
2.11
2.32
5.2
3.9
7.0
6.4
mmol/l
0.92
40
300
7
19
3.97
2.21
1.7
1.5
—
—
—
0
0
38
259
2.01
2.15
7.6
4.4
0.0
0.0
estimate
—
8
51
7
20
3.76
2.11
2.0
2.8
1.4
1.0
mmol/l
—
7
20
5
10
5.28
2.10
3.6
5.2
—
—
—
0
0
38
262
1.97
2.05
6.5
3.4
0.0
0.0
estimate
—
8
47
9
33
2.97
2.01
2.0
5.5
1.7
1.5
%
—
9
33
9
33
2.97
2.01
2.0
5.5
0.8
0.8
%
—
9
33
7
22
3.41
1.93
22.7
3.6
24.0
24.8
mmol/l
—
7
22
10
40
2.75
1.93
15.5
5.3
—
—
—
0
0
5
12
4.39
1.85
1.2
1.6
1.2
1.2
g/l
—
5
12
5
12
4.39
1.85
1.2
1.6
0.3
0.3
g/l
—
5
12
23
142
1.92
1.65
17.4
7.2
—
—
—
0
0
49
386
1.87
1.60
6.3
3.8
—
—
—
0
0
21
127
1.93
1.60
3.3
4.1
—
—
—
0
0
36
262
1.76
1.51
6.4
3.4
0.0
0.0
estimate
—
7
54
33
239
1.71
1.37
6.0
3.5
36.0
36.0
g/l
0.01
33
228
19
117
1.85
1.36
2.6
2.4
4.6
4.4
e6/l
0.05
19
105
17
103
1.86
1.27
9.3
3.7
—
—
—
0
0
7
31
2.39
1.14
2.3
5.8
92.0
94.4
%
—
7
31
27
194
1.63
1.12
4.6
3.1
77.1
37.4
e6/l
0.43
22
134
5
21
2.48
1.11
3.6
3.5
—
—
—
0
0
31
232
1.60
1.08
2.3
2.0
—
—
—
0
0
21
145
1.64
1.00
4.8
2.4
—
—
—
0
0
7
36
2.05
1.00
2.0
1.7
—
—
—
0
0
28
208
1.57
0.99
3.4
4.1
27.6
32.3
ng/l
0.23
20
136
10
55
1.95
0.98
2.0
1.7
—
—
—
0
0
6
27
2.33
0.96
1.7
3.5
0.6
0.1
e6/l
—
6
27
23
166
1.57
0.91
17.1
4.0
—
—
—
0
0
0
27
0.00
0.79
0.0
1.0
—
—
—
0
0
12
79
1.62
0.68
1.0
1.2
—
—
—
0
0
20
149
1.48
0.68
9.2
3.7
0.0
0.0
estimate
—
8
53
5
28
1.84
0.67
2.6
1.2
—
—
—
0
0
7
44
1.65
0.67
12.7
4.1
—
—
—
0
0
7
44
1.65
0.67
2.3
3.6
—
—
—
0
0
27
214
1.42
0.67
8.0
10.3
1.6
1.3
inr
—
10
64
20
150
1.46
0.65
2.0
3.8
—
—
—
0
0
9
62
1.52
0.56
1.7
1.6
—
—
—
0
0
11
77
1.51
0.49
2.3
1.7
—
—
—
0
0
13
95
1.45
0.48
1.9
1.9
—
—
—
0
0
8
59
1.40
0.43
2.1
1.7
—
—
—
0
0
9
65
1.44
0.41
1.4
1.3
—
—
—
0
0
18
147
1.30
0.35
2.6
3.9
11.6
10.5
mg/mmol
0.05
11
90
50
464
1.26
0.33
3.9
3.9
15.1
14.8
pmol/l
0.40
43
425
8
61
1.35
0.29
10.6
3.1
1.1
1.1
mmol/l
—
8
54
8
62
1.33
0.29
1.4
1.5
—
—
—
0
0
19
161
1.25
0.28
3.6
2.9
—
—
—
0
0
44
407
1.21
0.28
4.1
3.3
—
—
—
0
0
17
144
1.24
0.25
5.6
4.1
—
—
—
0
0
5
42
1.20
0.22
1.0
3.1
4.0
3.9
e9/l
—
5
33
23
204
1.19
0.22
7.8
3.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
6
47
1.30
0.21
2.8
2.9
3.3
3.5
ug/l
—
6
42
6
47
1.30
0.21
2.8
2.9
—
—
—
0
0
6
47
1.30
0.21
1.5
1.7
—
—
—
0
0
0
13
0.00
0.21
0.0
1.7
—
—
—
0
0
16
138
1.21
0.19
2.3
3.1
57.6
58.6
mg/l
0.01
11
88
10
120
0.81
0.18
2.3
1.4
1.8
2.7
g/l
—
5
65
8
67
1.22
0.17
1.5
1.3
—
—
—
0
0
18
163
1.14
0.12
4.9
1.9
—
—
—
0
0
20
217
0.89
0.11
1.6
1.8
108.7
94.2
pmol/l
—
9
104
5
48
1.04
0.09
1.8
1.8
0.2
0.2
g/l
—
5
43
5
61
0.81
0.08
1.6
1.5
—
—
—
0
0
15
163
0.90
0.08
1.6
1.4
—
—
—
0
0
56
547
1.11
0.08
4.8
4.3
5.8
5.8
mmol/l
0.10
51
505
14
128
1.12
0.07
13.3
2.8
93.7
93.0
%
0.05
14
128
62
610
1.13
0.07
15.1
11.8
—
—
—
0
0
20
192
1.06
0.02
2.7
3.0
—
—
—
0
0
59
597
0.93
0.02
23.4
14.1
4.0
4.0
mmol/l
0.11
59
582
54
546
0.95
0.00
5.2
4.7
2.2
1.9
mu/l
0.41
49
503
16
165
0.96
0.00
2.8
2.2
158.1
237.0
u/l
0.30
16
156
53
525
1.04
0.00
23.0
12.6
39.1
40.1
%
0.35
35
396
59
595
0.95
0.00
23.2
14.2
139.1
139.6
mmol/l
0.82
59
580
65
649
1.02
0.00
30.1
18.5
7.2
6.6
e9/l
1.18
65
636
65
647
1.05
0.00
30.0
18.6
260.2
254.5
e9/l
0.28
65
637
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
7
72
0.97
0.00
1.7
2.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
8
80
1.00
0.00
1.1
1.2
—
—
—
0
0
65
648
1.04
0.00
30.3
18.5
4.4
4.5
e12/l
0.25
65
634
0
5
0.00
0.00
0.0
1.0
—
1.0
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
2.8
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.9
—
33.1
—
0
9
62
618
1.03
0.00
21.7
14.4
80.5
74.7
umol/l
0.51
62
618
0
5
0.00
0.00
0.0
1.2
—
51.8
—
0
5
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
65
648
1.04
0.00
29.9
18.4
30.2
30.1
pg
0.07
65
643
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
65
648
1.04
0.00
29.9
18.5
90.5
90.6
fl
0.13
65
643
65
648
1.04
0.00
30.0
18.6
133.8
134.7
g/l
0.19
65
643
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.3
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint H7_LACRINAS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H7_LACRINAS.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

↥

Index endpoint: H7_LACRINAS – Other and unspecified disorders of lacrimal system

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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