lacrimal apparatus disease: A non-neoplastic or neoplastic disorder that affects the lacrimal apparatus. [ NCIT:C26809 ]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
71 |
4. Check minimum number of eventsNone |
71 |
5. Include endpointsNone |
71 |
6. Filter based on genotype QC (FinnGen only) |
71 |
Control definitions (FinnGen only)
- Control exclude
- H7_LIDLACRIMALORBIT
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified disorders of lacrimal system
based on the number of shared cases.
Similar with more cases:
- Disorders of lacrimal system
- Disorders of eyelid, lacrimal system and orbit
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 803 | 490 | 308 |
| Only index persons | 648 | 405 | 243 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 44.27 | 48.86 | 36.91 |
| Only index persons | 40.49 | 46.01 | 31.31 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 71 | 47 | 24 |
| Unadjusted period prevalence (%) | 0.01 | 0.02 | 0.01 |
| Median age at first event (years) | 41.50 | 44.74 | 35.16 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 64
- Matched controls
- 638
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H04.9
ICD-10 Finland
Disorder of lacrimal system, unspecified
+∞
24.5
22
*
36809
ICD-8 Finland
Inflammation of lachrymal glands and ducts, Unspecified
+∞
17.5
16
*
H04.8
ICD-10 Finland
Other disorders of lacrimal system
+∞
14.0
13
*
36808
ICD-8 Finland
Inflammation of lachrymal glands and ducts, Alii definiti
+∞
10.7
10
*
H04.5
ICD-10 Finland
Stenosis and insufficiency of lacrimal passages
+∞
10.7
10
*
H04.10
ICD-10 Finland
Dry eye syndrome
29.9
6.4
8
*
Mortality – FinRegistry
↥Association
Association between endpoint H7_LACRINAS and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have H7_LACRINAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: H7_LACRINAS – Other and unspecified disorders of lacrimal system
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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