Vibratory urticaria

L12_URTICA_VIBR

vibratory urticaria: This very rare form of angioedema develops in reply to contact with vibration. In vibratory angioedema, symptoms develop within two to five minutes after contact with vibration and dissolve after about an hour. Patients with this disorder do not suffer from dermographism or pressure urticaria. Vibratory angioedema is diagnosed by holding a vibrating device such as a laboratory vortex machine against the forearm for four minutes. Speedy swelling of the whole forearm extending into the upper arm is also noted later. The principal treatment is avoidance of vibratory stimulants. Antihistamines have also been proven helpful.[

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L50.4 Hospital discharge: ICD-9 — 7084 Cause of death: ICD-10 — L50.4 Cause of death: ICD-9 — 7084 2 out of 7 registries used, show all original rules.	27
4. Check minimum number of events None	27
5. Include endpoints None	27
6. Filter based on genotype QC (FinnGen only)	27

Control definitions (FinnGen only)

Control exclude: L12_URTICARIAERYTHEMA

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L50
Name in latin: Urticaria ex vibratione

NAME	L12_URTICA_VIBR
CONTROL_EXCLUDE	L12_URTICARIAERYTHEMA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L504
HD_ICD_9	7084
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L504
COD_ICD_9	7084
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Vibratory urticaria based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	154	107	45
Only index persons	138	99	39
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	47.17	48.81	42.73
Only index persons	45.55	47.80	39.84

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	27	20	7
Unadjusted period prevalence (%)	0.01	0.01	0.00
Median age at first event (years)	49.52	47.34	55.76

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3019225) pH of Specimen

4.81

2.17

3.3

3.5

—

(36660697) Celiac disease serology panel - Serum

3.55

1.69

1.2

1.1

—

(3009261) Glucose [Presence] in Urine by Test strip

123

0.42

1.18

3.6

4.0

—

0.0

—

(40758558) Short blood count panel - Blood

2.19

1.11

7.9

5.7

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

0.40

1.05

4.2

3.9

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.00

1.05

0.0

1.9

—

(3021601) Nitrite [Presence] in Urine by Test strip

119

0.45

1.00

4.6

5.3

—

0.0

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

177

0.49

0.95

3.4

3.5

—

(42870588) Differential panel, method unspecified - Blood

2.08

0.93

10.5

6.1

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

239

0.46

0.91

11.8

14.1

3.9

mmol/l

0.76

228

(3019550) Sodium [Moles/volume] in Serum or Plasma

238

0.47

0.88

11.7

14.1

140.7

139.6

mmol/l

1.11

228

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.84

0.0

2.0

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

209

0.50

0.83

6.0

5.3

37.0

39.3

mmol/mol

0.92

193

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

231

0.48

0.80

6.5

4.7

2.8

mmol/l

0.01

212

(3035350) Ketones [Presence] in Urine by Test strip

119

0.54

0.80

3.3

4.1

—

0.0

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

229

0.51

0.77

5.5

4.2

5.0

4.8

mmol/l

0.47

210

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

175

1.90

0.69

11.0

8.2

63.0

74.6

u/l

3.22

160

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.61

0.0

2.0

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.79

0.55

1.7

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

1.68

0.50

3.5

3.1

582.3

771.6

ng/l

—

(3022948) Iron [Moles/volume] in Serum or Plasma

1.57

0.43

2.8

3.0

13.9

13.8

umol/l

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.42

0.0

2.1

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

0.00

0.42

0.0

2.0

—

0.0

—

(3008152) Bicarbonate [Moles/volume] in Arterial blood

0.00

0.42

0.0

12.3

—

25.1

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.52

0.42

1.0

1.5

—

(40761536) Microorganisms panel - Urine sediment

0.00

0.41

0.0

2.9

—

(3019069) Monocytes/100 leukocytes in Blood

103

1.51

0.38

12.2

5.4

9.2

7.8

1.07

(3006315) Basophils [#/volume] in Blood

114

1.47

0.35

11.0

5.8

0.1

0.0

e9/l

0.72

101

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.43

0.34

1.9

2.2

—

(3018010) Neutrophils/100 leukocytes in Blood

105

1.46

0.33

11.2

5.0

59.8

56.2

0.62

(3001604) Monocytes [#/volume] in Blood

115

1.45

0.33

11.0

5.7

0.6

e9/l

0.42

101

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

0.63

0.31

3.4

3.3

—

(3002030) Lymphocytes/100 leukocytes in Blood

107

1.41

0.29

12.1

5.1

26.4

28.8

0.34

(3044889) 12 lead EKG panel

161

0.73

0.25

2.9

3.4

—

(3019198) Lymphocytes [#/volume] in Blood

120

1.35

0.23

11.1

5.6

1.6

1.9

e9/l

0.94

105

(3013115) Eosinophils [#/volume] in Blood

120

1.35

0.23

11.1

6.3

0.3

0.2

e9/l

0.72

108

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.22

0.0

1.5

—

(3019473) Protein [Mass/volume] in Cerebral spinal fluid

0.00

0.22

0.0

1.2

—

611.0

—

(3018405) Lactate [Moles/volume] in Arterial blood

0.00

0.22

0.0

9.8

—

1.2

—

(3019060) Gas panel - Arterial blood

0.00

0.21

0.0

6.8

—

(3020961) Endomysium IgA Ab [Titer] in Serum

0.00

0.21

0.0

1.2

—

(3015736) pH of Urine

0.78

0.17

3.1

4.1

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.17

0.10

1.8

2.2

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.78

0.09

1.0

1.6

—

(36304419) Bacteria [Presence] in Urine

0.75

0.09

1.8

2.5

—

(3031040) Bacteria [#/volume] in Urine by Automated count

152

0.84

0.09

2.5

4.0

—

43.4

—

(3018418) pH of Serum or Plasma

1.16

0.09

1.8

3.9

—

7.4

—

(3044640) Blood type and Crossmatch panel - Blood

1.16

0.09

2.3

2.2

—

(3037467) Urinalysis macro (dipstick) panel - Urine

156

0.91

0.01

4.9

4.2

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

115

0.93

0.00

4.4

4.2

—

(40768804) Tissue Pathology biopsy report

1.02

0.00

1.6

1.9

—

(3023368) Bacteria identified in Blood by Culture

1.05

0.00

1.4

4.4

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

0.00

0.0

2.0

—

0.3

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

1.00

0.00

1.8

1.6

0.4

0.7

mg/l

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

0.83

0.00

4.0

5.0

—

(3020044) Glucose [Moles/volume] in Cerebral spinal fluid

0.00

0.0

1.1

—

3.6

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

0.00

0.0

2.0

—

1.2

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.0

1.0

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

0.00

0.0

1.4

—

68.1

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.0

1.4

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

218

1.05

0.00

4.9

4.4

5.6

5.9

mmol/l

0.78

196

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.0

1.0

—

(3047181) Lactate [Moles/volume] in Blood

0.00

0.0

10.9

—

0.9

—

(3018572) Chloride [Moles/volume] in Blood

0.00

0.0

10.3

—

104.3

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

0.00

0.0

1.6

—

(3049717) Cytology report of Urine Cyto stain

0.00

0.0

2.7

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

0.0

1.1

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.4

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

0.00

0.0

2.6

—

1.0

—

(3011288) Drugs identified in Urine by Screen method

0.00

0.0

1.0

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.2

—

(3012413) Glucose [Moles/volume] in Serum or Plasma --2 hours post meal

0.00

0.0

1.6

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

3.0

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.4

—

(4094501)

0.00

0.0

1.0

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(3032836) C peptide [Moles/volume] in Serum or Plasma --fasting

0.00

0.0

1.2

—

1.0

—

(3020891) Body temperature

0.00

0.0

4.0

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.4

—

(1761868) Lipid panel - Serum or Plasma

1.00

0.00

1.8

3.0

—

(3003694) ABO and Rh group [Type] in Blood

0.96

0.00

2.2

1.4

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

0.00

0.0

2.6

—

0.7

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.0

3.4

—

(3044941) Cell count panel - Synovial fluid

0.00

0.0

1.3

—

(3025547) Thyroglobulin Ab [Units/volume] in Serum or Plasma

0.00

0.0

2.2

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

6.8

—

33.5

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.0

1.0

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.4

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.4

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.0

1.3

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.4

—

(3039000) Anion gap in Blood

0.00

0.0

10.3

—

10.0

—

(3009542) Hematocrit [Volume Fraction] of Blood

215

1.13

0.00

16.1

12.5

40.2

0.02

159

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

0.00

0.0

1.3

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.0

2.1

—

33.4

—

(4034850)

0.00

0.0

12.8

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

0.00

0.0

1.5

—

24.8

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_URTICA_VIBR and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_URTICA_VIBR.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: L12_URTICA_VIBR – Vibratory urticaria

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Vibratory urticaria

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints