Knuckle pads

M13_KNUCKLEPADS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M72.1
  • Cause of death: ICD-10 M72.1

2 out of 7 registries used, show all original rules.

59

4. Check minimum number of events

None

59

5. Include endpoints

None

59

6. Filter based on genotype QC (FinnGen only)

59

Control definitions (FinnGen only)

Control exclude
M13_SOFTTISSUE

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M72

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 435 219 216
Only index persons 400 203 197
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population - 54.15 51.83
Only index persons 52.14 53.44 50.80

-FinnGen-

Key figures

All Female Male
Number of individuals 59 28 31
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 55.75 52.08 59.06

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
53
Matched controls
529
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M72.1
ICD-10 Finland
Knuckle pads
+∞
75.9
53
*
NDM10
NOMESCO Finland
Palmar fasciotomy of hand
+∞
13.0
12
*
M75.1
ICD-10 Finland
Rotator cuff syndrome
10.4
10.9
23
36
M72.0
ICD-10 Finland
Palmar fascial fibromatosis [Dupuytren]
53.1
8.0
9
*
N02AX02
ATC
tramadol; systemic, rectal
5.5
7.9
35
138
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
5.1
7.2
29
101
M54.5
ICD-10 Finland
Low back pain
5.0
6.9
27
91
J01DA01
ATC
[U] cefalexin; systemic
4.8
6.0
42
235

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
37
201
3.25
4.60
4.6
6.3
1.8
1.7
e9/l
0.33
31
177
36
194
3.19
4.51
4.6
6.3
0.1
0.0
e9/l
2.09
29
162
37
203
3.21
4.48
4.6
7.3
0.2
0.2
e9/l
0.44
29
175
35
193
3.00
4.09
4.7
6.4
0.6
0.6
e9/l
0.15
28
160
23
101
3.09
4.02
2.9
1.9
2.4
3.2
mg/l
1.14
23
79
42
259
3.16
3.96
5.2
12.0
4.4
4.4
e9/l
0.08
34
217
28
140
2.90
3.86
4.5
4.5
—
—
—
0
0
32
179
2.72
3.48
4.8
3.4
84.5
80.9
e6/l
0.02
25
122
41
274
2.63
2.92
6.4
4.8
6.4
6.8
mmol/l
0.83
41
253
31
183
2.46
2.87
2.6
1.9
90.6
92.1
pmol/l
0.06
16
94
24
126
2.53
2.85
3.6
3.9
—
—
—
0
0
5
6
8.95
2.80
2.6
1.3
—
—
—
0
0
13
53
2.86
2.48
1.0
1.3
—
—
—
0
0
14
60
2.75
2.44
4.4
2.1
2.4
2.4
g/l
0.02
14
55
33
212
2.26
2.40
8.9
9.9
0.0
0.0
e9/l
0.71
24
169
43
311
2.41
2.33
7.1
3.9
—
—
—
0
0
24
137
2.27
2.29
4.0
2.8
—
—
—
0
0
14
62
2.65
2.29
4.6
2.1
12.7
12.4
umol/l
0.07
14
57
12
50
2.76
2.19
1.9
2.4
1.5
1.7
%
0.33
12
44
25
152
2.12
2.00
6.5
3.2
—
—
—
0
0
7
22
3.47
1.95
2.7
2.0
—
—
—
0
0
6
17
3.80
1.89
2.3
3.2
—
—
—
0
0
43
326
2.18
1.87
4.3
3.7
13.9
12.3
mm/h
0.25
43
291
8
30
2.92
1.80
6.0
3.9
—
—
—
0
0
31
212
1.97
1.75
8.4
3.7
34.9
35.4
g/l
0.14
31
199
17
96
2.08
1.60
3.2
3.1
30.0
100.2
ng/l
0.76
17
81
31
219
1.88
1.53
4.5
4.0
0.0
0.0
estimate
—
8
47
13
67
2.21
1.52
2.5
2.0
—
—
—
0
0
12
60
2.26
1.51
3.0
1.6
—
—
—
0
0
7
28
2.70
1.50
8.1
10.2
—
—
—
0
0
26
176
1.85
1.45
5.4
2.5
90.2
130.7
ug/l
0.96
26
162
5
17
3.11
1.39
2.6
4.1
—
—
—
0
0
28
197
1.80
1.36
13.6
8.3
1.3
1.2
inr
0.06
11
58
8
38
2.27
1.24
2.5
1.5
—
—
—
0
0
30
221
1.73
1.21
6.1
5.2
0.0
0.0
estimate
—
9
40
23
158
1.75
1.18
2.5
2.2
—
—
—
0
0
19
124
1.79
1.15
3.1
8.0
—
—
—
0
0
8
41
2.10
1.14
6.3
2.7
—
—
—
0
0
16
100
1.82
1.11
3.8
4.6
—
—
—
0
0
10
53
2.07
1.09
1.2
1.3
—
—
—
0
0
30
226
1.67
1.09
4.6
3.9
0.0
0.0
estimate
—
9
42
5
22
2.39
1.05
4.0
2.8
—
—
—
0
0
11
177
0.53
1.03
2.9
2.8
—
—
—
0
0
9
50
1.94
1.02
3.4
1.6
—
—
—
0
0
54
487
2.28
1.01
24.0
15.9
3.9
4.0
mmol/l
0.30
54
468
54
486
2.31
1.01
24.0
15.8
139.5
139.7
mmol/l
0.17
54
467
6
27
2.36
0.96
2.5
2.1
0.6
0.1
e6/l
—
6
27
14
88
1.77
0.95
2.4
5.4
—
—
—
0
0
25
186
1.60
0.92
2.4
2.3
—
—
—
0
0
6
31
2.04
0.87
2.7
3.9
—
0.4
—
0
8
6
32
1.97
0.84
1.8
1.6
—
—
—
0
0
6
32
1.97
0.84
5.7
3.2
—
7.4
—
0
6
23
172
1.55
0.81
4.0
4.0
—
—
—
0
0
9
55
1.75
0.78
1.0
1.5
—
—
—
0
0
54
498
1.99
0.74
23.3
16.2
89.1
79.4
umol/l
0.43
54
498
7
41
1.80
0.73
7.0
2.7
2.9
2.1
mmol/l
—
7
30
45
395
1.59
0.72
22.5
17.4
13.8
13.9
%
0.14
45
380
5
27
1.93
0.70
3.0
4.2
—
0.0
—
0
7
40
344
1.51
0.69
3.7
3.8
—
—
—
0
0
5
29
1.79
0.65
1.0
1.3
—
—
—
0
0
10
64
1.68
0.63
15.5
4.3
1.1
1.0
mmol/l
—
10
59
6
34
1.85
0.61
2.7
3.7
—
0.9
—
0
10
18
137
1.45
0.56
3.8
4.0
—
—
—
0
0
7
49
1.49
0.48
4.0
1.5
—
—
—
0
0
5
31
1.67
0.44
17.2
11.2
94.3
93.2
%
—
5
31
5
32
1.61
0.43
1.0
1.3
—
—
—
0
0
10
71
1.49
0.42
4.0
1.8
—
—
—
0
0
5
33
1.56
0.42
1.8
1.4
—
—
—
0
0
5
33
1.56
0.42
1.0
4.1
—
—
—
0
0
0
15
0.00
0.42
0.0
1.6
—
1.3
—
0
15
0
15
0.00
0.42
0.0
1.6
—
0.3
—
0
15
0
15
0.00
0.42
0.0
3.9
—
—
—
0
0
5
34
1.51
0.41
1.0
5.1
69.7
68.6
g/l
—
5
29
9
65
1.45
0.41
1.6
1.3
—
—
—
0
0
6
45
1.37
0.35
14.0
8.6
—
—
—
0
0
6
45
1.37
0.35
6.3
3.2
—
—
—
0
0
13
102
1.35
0.33
1.5
1.4
1.3
1.4
mg/l
—
8
81
15
121
1.32
0.32
5.1
4.7
0.0
0.0
estimate
—
9
42
17
140
1.30
0.32
4.7
3.7
8.6
9.6
mg/mmol
0.04
12
86
13
103
1.34
0.31
2.5
1.9
455.7
412.0
pmol/l
0.26
13
87
26
229
1.24
0.29
10.0
5.6
1.2
1.2
mmol/l
0.40
26
200
20
172
1.25
0.27
2.4
4.2
48.0
42.5
ng/l
0.07
11
125
0
11
0.00
0.21
0.0
2.0
—
—
—
0
0
0
11
0.00
0.21
0.0
3.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
12
0.00
0.21
0.0
2.7
—
—
—
0
0
0
14
0.00
0.20
0.0
9.4
—
—
—
0
0
10
81
1.28
0.20
1.2
1.6
2.1
2.9
g/l
—
5
50
20
180
1.17
0.16
4.2
4.8
2.0
1.9
ug/l
0.08
20
154
5
47
1.07
0.09
1.0
2.4
4.7
10.5
ug/l
—
5
39
42
427
0.94
0.01
22.4
15.1
40.0
39.4
%
0.20
29
299
13
124
1.06
0.01
5.8
3.2
—
—
—
0
0
13
126
1.04
0.00
1.8
1.4
—
—
—
0
0
13
126
1.04
0.00
1.8
1.6
1.1
1.4
mmol/l
1.28
13
98
50
497
1.04
0.00
17.0
12.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
3.6
—
108.4
—
0
5
0
7
0.00
0.00
0.0
1.1
—
66.5
—
0
7
0
9
0.00
0.00
0.0
1.2
—
55.7
—
0
9
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
—
—
0
0
0
5
0.00
0.00
0.0
3.6
—
4.0
—
0
5
0
5
0.00
0.00
0.0
2.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
4.8
—
11.5
—
0
5
0
5
0.00
0.00
0.0
3.6
—
—
—
0
0
0
7
0.00
0.00
0.0
21.9
—
1831.3
—
0
7
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
2.0
—
—
—
0
0
0
9
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
6.8
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
90.0
—
0
6
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
2.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint M13_KNUCKLEPADS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have M13_KNUCKLEPADS.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: M13_KNUCKLEPADS – Knuckle pads

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data