Complications of anaesthesia during labour and delivery

O15_LABOUR_ANEST_COMPLIC

No definition available.

Endpoint definition

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Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule only females	293218
2. Check conditions None	293218
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — O74 Hospital discharge: ICD-9 — 668 Hospital discharge: ICD-8 — 6629 Cause of death: ICD-10 — O74 Cause of death: ICD-9 — 668 Cause of death: ICD-8 — 6629 2 out of 7 registries used, show all original rules.	147
4. Check minimum number of events None	147
5. Include endpoints None	147
6. Filter based on genotype QC (FinnGen only)	143

Control definitions (FinnGen only)

Control exclude: O15_COMPLIC_LAB_DELIV

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF5
Parent code in ICD-10: O60-O75
Name in latin: Complicationes ex anaesthesia intra labores/partum

NAME	O15_LABOUR_ANEST_COMPLIC
CONTROL_EXCLUDE	O15_COMPLIC_LAB_DELIV
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX	2
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	O74
HD_ICD_9	668
HD_ICD_8	6629
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	O74
COD_ICD_9	668
COD_ICD_8	6629
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Complications of anaesthesia during labour and delivery based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1122	1122	-
Only index persons	1109	1109	-
Unadjusted period prevalence (%)
Whole population	0.03	0.03	-
Only index persons	0.04	0.04	-
Median age at first event (years)
Whole population	-	29.82	-
Only index persons	-	29.87	-

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	143	143	-
Unadjusted period prevalence (%)	0.05	0.05	-
Median age at first event (years)	30.45	30.45	-

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
147: Matched controls
1470

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

O74.5

ICD-10 Finland

Spinal and epidural anaesthesia-induced headache during labour and delivery

+∞

113.8

TAB22

NOMESCO Finland

Stoppin epidural fluid escape with coagulated blood

191.7

82.5

O68.0

ICD-10 Finland

Labour and delivery complicated by fetal heart rate anomaly

+∞

22.5

ZXD05

NOMESCO Finland

Urgent procedure

5.1

21.9

278

O81.4

ICD-10 Finland

Vacuum extractor delivery

27.4

21.4

MCA10

NOMESCO Finland

Lower uterine segment caesarean section

5.8

17.3

MAE00

NOMESCO Finland

Outlet vacuum delivery

22.4

16.2

O74.0

ICD-10 Finland

Aspiration pneumonitis due to anaesthesia during labour and delivery

+∞

15.9

Z34.8

ICD-10 Finland

Supervision of other normal pregnancy

3.9

14.9

284

WX321

NOMESCO Finland

Acute spinal anesthesia for delivery

5.6

14.8

MA2AE

NOMESCO Finland

Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus

3.7

13.7

311

MA2HE

NOMESCO Finland

Detailed morfological ultrasound examination of fetus

3.5

12.2

293

O99.80

ICD-10 Finland

The fear of childbirth

4.8

12.1

Z39.2

ICD-10 Finland

Routine postpartum follow-up

3.5

12.1

267

SPAT1379

SPAT

Health check-up of pregnant person

3.5

11.5

227

WX306

NOMESCO Finland

Lumbar epidural anesthesy

4.6

11.4

Z36.3

ICD-10 Finland

Antenatal screening for malformations using ultrasound and other physical methods

3.3

11.3

485

W78

ICPC

Pregnancy

3.1

10.6

351

MA2JE

NOMESCO Finland

Ultrasound screening of fetal nuchal translucency

3.5

10.1

166

O47.0

ICD-10 Finland

False labour before 37 completed weeks of gestation

3.5

9.8

151

O63.1

ICD-10 Finland

Prolonged second stage (of labour)

+∞

9.5

Z3232

NOMESCO Finland

Midwife

3.2

9.0

171

O82.10

ICD-10 Finland

Delivery by emergency caesarean section

9.2

8.9

O72.2

ICD-10 Finland

Delayed and secondary postpartum haemorrhage

95.3

8.5

O60

ICD-10 Finland

Preterm labour and delivery

+∞

8.4

Z34.0

ICD-10 Finland

Supervision of normal first pregnancy

2.8

7.8

238

SPAT1380

SPAT

Postpartum check-up

2.9

7.8

197

Z34.9

ICD-10 Finland

Supervision of normal pregnancy, unspecified

2.8

7.6

214

O74.8

ICD-10 Finland

Other complications of anaesthesia during labour and delivery

+∞

7.3

6688X

ICD-9 Finland

Complications of the administration of anaesthetic or other sedation in labour and delivery, Other complications of anaesthesia or other sedation in labour and delivery

+∞

7.3

O70.1

ICD-10 Finland

Second degree perineal laceration during delivery

+∞

7.3

ZXE00

NOMESCO Finland

One hour or less

2.6

7.3

400

O24.4

ICD-10 Finland

Diabetes mellitus arising in pregnancy

3.1

7.2

140

WX307

NOMESCO Finland

Obstetric epidural analgesia

2.8

7.0

181

WX602

NOMESCO Finland

Repeated or continuing anesthesia shots throug a catheter

3.1

7.0

124

SPAT1197

SPAT

Extensive health check-up of expecting family

2.6

6.8

275

O64.1

ICD-10 Finland

Obstructed labour due to breech presentation

+∞

6.3

O64.0

ICD-10 Finland

Obstructed labour due to incomplete rotation of fetal head

+∞

6.3

O68.8

ICD-10 Finland

Labour and delivery complicated by other evidence of fetal stress

+∞

6.3

O80.0

ICD-10 Finland

Spontaneous vertex delivery

2.4

6.2

592

O34.2

ICD-10 Finland

Maternal care due to uterine scar from previous surgery

5.9

6.0

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

205

2.72

6.72

1.7

1.5

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

396

2.40

6.27

2.1

1.7

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

578

2.37

6.01

9.0

4.3

5.93

6.18

mmol/l

0.53

519

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

547

2.13

4.80

3.4

2.3

—

(3050129) First trimester maternal screen panel - Serum or Plasma

116

2.63

4.41

1.7

1.4

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

2.75

4.21

2.2

1.7

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

2.68

4.04

1.5

1.4

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

2.64

3.78

1.5

1.4

—

(3005033) Fetal Nuchal fold Thickness US

2.64

3.78

1.5

1.4

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

3.26

3.64

1.3

1.1

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

107

2.49

3.62

2.0

1.5

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

108

2.46

3.55

1.5

1.3

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

108

2.46

3.55

1.5

1.3

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

108

2.46

3.55

1.5

1.3

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

108

2.46

3.55

1.5

1.3

—

(3003694) ABO and Rh group [Type] in Blood

437

1.87

3.38

2.1

1.7

—

(3044290) Cell count panel - Cerebral spinal fluid

4.97

3.29

1.0

1.1

—

(3022806) Fractional oxyhemoglobin in Capillary blood

8.87

3.29

3.3

1.3

93.42

89.77

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

2.58

3.22

1.8

1.4

—

(3026008) Bacteria identified in Urine by Culture

322

1.89

3.18

3.3

2.1

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

327

1.86

3.01

2.7

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

757

1.83

2.97

4.1

3.1

52.99

56.19

ug/l

0.15

708

(46235355) HIV 1 and 2 tests - Meaningful Use set

507

1.77

2.92

2.1

—

(3044640) Blood type and Crossmatch panel - Blood

331

1.83

2.88

2.8

1.9

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

114

2.21

2.74

1.6

1.5

—

(3019832) Treponema pallidum Ab [Presence] in Serum

362

1.78

2.72

1.9

1.7

—

(3030467) Casts [#/volume] in Urine by Automated count

262

1.84

2.67

2.5

0.18

0.24

e6/l

0.26

185

(3011397) Hemoglobin [Presence] in Urine by Test strip

246

1.86

2.66

3.2

2.9

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

279

1.82

2.65

2.4

2.7

41.64

14.89

ng/l

0.72

103

(3018095) Leukocytes [#/volume] in Urine

366

1.75

2.60

2.7

3.1

49.02

45.22

e6/l

0.05

224

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

3.13

2.55

1.4

—

(3026389) Candida sp identified in Specimen by Organism specific culture

3.97

2.50

1.4

—

(36304419) Bacteria [Presence] in Urine

269

1.79

2.43

2.5

2.4

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

182

1.89

2.36

1.6

2.0

—

(3021601) Nitrite [Presence] in Urine by Test strip

596

1.66

2.36

5.1

4.0

0.00

0.01

estimate

0.50

129

(3035350) Ketones [Presence] in Urine by Test strip

599

1.64

2.29

4.1

2.9

0.00

estimate

-0.00

128

(3037467) Urinalysis macro (dipstick) panel - Urine

102

844

1.68

2.19

5.4

3.5

—

(3009261) Glucose [Presence] in Urine by Test strip

604

1.62

2.18

4.1

2.9

0.00

estimate

-0.00

127

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

130

1156

2.08

2.16

4.5

4.1

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

5.13

2.08

1.0

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

5.13

2.08

1.6

1.3

—

(40761535) Cells panel - Urine sediment

2.35

2.08

2.5

3.2

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.93

2.04

14.9

9.8

23.56

25.22

mmol/l

—

(3029937) Albumin [Presence] in Urine by Test strip

318

1.65

1.99

5.0

3.3

0.00

0.01

estimate

0.50

126

(4034850) Laboratory test

3.07

1.96

4.1

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

4.66

1.95

1.0

1.1

—

(3001019) Free T4 and TSH panel - Serum or Plasma

130

1.91

1.95

1.7

1.4

—

(1616796) Gas panel - Central venous blood

3.86

1.95

2.0

1.3

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

2.75

1.90

1.1

1.3

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

2.75

1.90

1.0

1.1

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

245

1.68

1.88

3.0

1.8

—

(3034603) RHD gene allele [Genotype] in Blood or Tissue by Molecular genetics method Nominal

3.63

1.85

1.8

1.4

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

4.27

1.84

3.2

2.1

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

4.27

1.84

1.0

—

(3023410) Appearance of Cerebral spinal fluid

4.27

1.84

1.0

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.86

1.82

41.6

13.9

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.11

1.77

2.9

3.2

—

(3013290) Carbon dioxide [Partial pressure] in Blood

3.66

1.63

5.0

1.6

4.96

5.11

kpa

—

(3027315) Oxygen [Partial pressure] in Blood

3.66

1.63

5.0

1.6

9.88

9.32

kpa

—

(3002582) Erythrocytes [#/volume] in Urine

289

1.58

1.62

2.5

2.7

12.28

149.90

e6/l

0.75

208

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

307

1.57

1.60

1.4

2.0

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.77

1.60

2.0

1.2

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

147

1.76

1.60

2.2

2.0

0.71

1.00

e6/l

0.42

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

2.93

1.52

2.3

2.7

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

2.93

1.52

1.2

1.3

—

(3019060) Gas panel - Arterial blood

2.52

1.51

12.0

5.5

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

118

1.80

1.50

4.6

2.4

23.37

26.08

0.54

107

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.92

1.48

1.9

1.3

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

2.13

1.48

1.4

1.7

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

3.20

1.45

1.0

1.1

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

3.20

1.45

1.0

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.90

1.44

2.1

1.3

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

144

1.71

1.43

3.2

2.2

3783.27

68.07

ng/l

0.46

(3022217) INR in Platelet poor plasma by Coagulation assay

315

1.52

1.42

12.2

6.5

1.06

1.04

inr

0.10

117

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

2.48

1.41

1.9

1.3

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.83

1.38

1.1

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

3.01

1.37

1.4

1.1

—

(3000991) Gas panel - Venous blood

2.22

1.36

37.2

13.0

—

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

148

1.66

1.30

1.0

1.3

101.16

161.04

iu/ml

—

(3009343) pH of Capillary blood

2.11

1.29

1.2

3.5

—

7.43

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

478

1.43

1.29

4.7

2.9

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

2.29

1.26

1.1

1.2

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

132

1225

1.76

1.26

14.1

9.3

18.37

17.03

mg/l

0.23

108

898

(3012516) Albumin [Mass/volume] in Urine

176

1.58

1.21

3.8

3.5

38.92

42.42

mg/l

0.05

117

(3047007) Chlamydophila sp Ab [Presence] in Serum

2.36

1.20

1.0

1.3

—

(3012544) pH of Venous blood

2.03

1.14

9.6

2.9

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

116

1056

1.47

1.08

4.3

4.5

13.95

14.22

pmol/l

0.70

111

978

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

2.02

1.06

1.1

1.4

—

(40760892) CBC W Ordered Manual Differential panel - Blood

553

1.35

1.00

8.8

6.2

—

(3001604) Monocytes [#/volume] in Blood

592

1.35

0.99

7.2

5.3

0.50

0.52

e9/l

0.39

525

(3014007) Fractional oxyhemoglobin in Arterial blood

1.99

0.98

35.3

15.6

95.21

95.28

—

(40761536) Microorganisms panel - Urine sediment

126

1.58

0.97

6.7

3.3

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

126

1.58

0.97

3.8

2.6

0.85

0.82

mmol/l

0.47

120

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

143

1.55

0.96

1.3

1.6

—

(3020682) Albumin/Creatinine [Ratio] in Urine

186

1.48

0.96

4.4

4.0

5.04

9.17

mg/mmol

0.46

115

(3025941) Bacteria identified in Stool by Culture

1.73

0.95

1.5

1.3

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

2.27

0.94

1.7

1.5

—

(3018418) pH of Serum or Plasma

258

1.41

0.93

5.6

3.6

7.41

7.40

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

105

0.46

0.92

8.6

3.0

31.60

32.22

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

2.19

0.92

1.0

1.1

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

232

1.43

0.91

2.0

1.6

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

1.91

0.89

1.3

1.1

—

(40768443) Skin Pathology biopsy report

2.04

0.88

1.0

1.1

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

243

1.41

0.87

1.3

1.8

—

(3006315) Basophils [#/volume] in Blood

591

1.32

0.87

7.3

5.4

0.04

e9/l

0.68

521

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

457

1.33

0.86

1.4

1.5

—

(3034770) Mitochondria Ab [Titer] in Serum

1.97

0.85

1.2

—

(3019198) Lymphocytes [#/volume] in Blood

622

1.31

0.85

7.1

5.2

1.90

1.97

e9/l

0.36

564

(3044889) 12 lead EKG panel

672

1.31

0.84

2.5

2.4

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.75

0.78

2.6

1.5

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

294

1.35

0.77

2.6

1.7

0.73

0.76

mg/l

0.06

211

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

1.88

0.74

35.1

14.8

0.86

0.71

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

1.88

0.74

35.1

14.8

1.47

1.27

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

296

1.33

0.74

3.0

2.0

2.60

2.58

mg/l

0.02

260

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

2.03

0.73

1.2

1.1

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

1.79

0.72

5.6

2.5

78.00

100.53

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

1.95

0.71

14.4

2.5

22.60

24.28

mmol/l

—

(3013115) Eosinophils [#/volume] in Blood

623

1.27

0.71

7.7

5.9

0.22

0.16

e9/l

0.66

556

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

1.81

0.67

1.0

1.6

95.80

53.83

ng/l

—

(3042936) Bacteria identified in Isolate by Culture

139

1.42

0.64

1.9

1.8

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.59

0.64

1.3

1.1

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

413

0.77

0.63

2.5

2.1

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.52

0.63

1.2

—

(3005136) Cladosporium herbarum IgE Ab [Units/volume] in Serum

1.69

0.62

1.0

—

0.02

—

(3023368) Bacteria identified in Blood by Culture

185

1.36

0.61

4.3

3.3

—

(3026725) Estradiol (E2) [Moles/volume] in Serum or Plasma

1.54

0.59

1.1

1.5

0.31

0.39

nmol/l

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

420

1.25

0.58

15.5

6.0

1.21

1.22

mmol/l

0.29

358

(3014576) Chloride [Moles/volume] in Serum or Plasma

1.55

0.58

28.7

9.4

103.91

105.16

mmol/l

0.43

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

364

1.26

0.56

1.3

0.56

2.19

u/ml

0.88

107

(40768797) Stomach Pathology biopsy report

134

1.39

0.56

1.2

1.1

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

134

1.39

0.56

2.2

1.4

—

(3011288) Drugs identified in Urine by Screen method

0.60

0.54

2.7

2.0

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

1.49

0.53

1.4

1.5

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

103

961

1.24

0.53

4.3

3.8

35.87

36.84

mmol/mol

0.64

909

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

237

1.28

0.50

1.2

20.70

21.99

iu/ml

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

454

0.81

0.50

2.7

2.2

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

257

1.26

0.48

1.6

1.5

—

(3023351) European house dust mite IgE Ab [Units/volume] in Serum

1.51

0.48

1.1

—

7.69

u/ml

—

(3013707) Erythrocyte sedimentation rate by Westergren method

875

1.21

0.47

3.5

3.6

8.59

8.27

mm/h

0.13

811

(3048689) Calprotectin [Mass/mass] in Stool

213

1.27

0.45

2.8

2.5

81.75

68.82

ug/g

0.23

154

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

140

1.33

0.44

2.3

2.2

3.37

7.10

e6/l

—

(3000494) Fungus identified in Specimen by Culture

131

1.34

0.44

1.5

1.2

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

1.63

0.43

2.6

5.2

58.80

58.61

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

1.63

0.43

2.6

4.5

3.27

4.53

e9/l

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.2

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.1

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.2

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.2

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.2

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.2

—

(3049717) Cytology report of Urine Cyto stain

0.00

0.41

0.0

1.5

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.2

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.41

0.0

1.2

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.40

0.0

2.9

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

0.40

0.0

1.6

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

1.44

0.39

1.2

—

(36660697) Celiac disease serology panel - Serum

114

0.68

0.39

1.1

1.2

—

(3041096) Erythrocytes [Presence] in Urine by Automated

379

1.19

0.38

4.4

2.5

—

(3003327) Ova and parasites identified in Stool by Light microscopy

1.30

0.37

2.1

1.7

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

1.45

0.36

1.0

1.1

—

(40768793) Breast Pathology biopsy report

1.45

0.36

1.7

1.2

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

119

1144

1.21

0.36

3.5

3.1

1.53

mmol/l

0.06

114

1090

(3045414) Leukocytes [Presence] in Urine

1.41

0.35

1.5

1.4

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

120

1155

1.21

0.35

3.7

3.3

2.85

2.83

mmol/l

0.10

114

1096

(3021589) Normoblasts [#/volume] in Blood

529

1.16

0.34

10.2

7.0

0.00

e9/l

0.81

428

(3002256) Pathology report gross observation

146

1.27

0.34

1.1

1.2

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

451

1.16

0.34

2.3

1.7

—

(3018171) Choriogonadotropin [Units/volume] in Serum or Plasma

176

1.23

0.31

2.4

2.1

1724.45

6948.78

u/l

0.98

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

1.31

0.31

2.0

1.5

—

(4200892) Spirometry reversibility

1.31

0.31

1.6

1.3

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

139

1.25

0.30

1.6

1.4

—

(3007853) Bacteria identified in Skin by Aerobe culture

131

1.25

0.28

1.5

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

113

1089

1.16

0.28

3.2

2.8

1.07

1.13

mmol/l

0.53

108

1025

(3016879) Cocaine [Presence] in Urine

128

0.77

0.28

1.5

1.6

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

380

1.15

0.27

2.2

1.8

96.22

93.89

pmol/l

0.17

208

(4035726) Immunohistochemistry procedure

1.32

0.27

1.8

1.3

—

(3022621) pH of Urine by Test strip

1.21

0.27

2.6

2.2

—

(3019225) pH of Specimen

0.69

0.27

5.6

4.2

—

(3007164) IgA [Mass/volume] in Serum or Plasma

327

0.86

0.26

2.0

1.4

2.16

2.06

g/l

0.16

213

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.76

0.23

1.6

1.3

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

230

1.16

0.22

1.1

1.2

1.04

7.40

u/ml

—

104

(3024354) Oxygen [Partial pressure] in Venous blood

1.23

0.22

13.6

3.1

4.94

5.19

kpa

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

145

1.19

0.22

1.5

2.1

2.38

2.41

mmol/l

0.39

129

(3020961) Endomysium IgA Ab [Titer] in Serum

1.26

0.21

1.2

1.1

—

132.00

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.0

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

0.21

0.0

1.9

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.1

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.1

—

122.18

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.21

0.0

3.0

—

7.32

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.21

0.0

1.3

—

(3002670) Multiple inhalant allergen IgE Ab [Units/volume] in Serum

0.00

0.20

0.0

1.1

—

(3013512) EKG study

217

0.86

0.20

4.2

2.6

—

(1002224) Polysomnography panel

1.17

0.18

1.3

1.0

—

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

110

1.20

0.18

3.0

2.1

34.28

57.56

u/ml

0.46

102

(21494755) Public health laboratory ask at order entry panel

200

1.12

0.13

1.5

1.2

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

136

0.87

0.11

1.2

1.3

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

107

1.13

0.09

5.1

4.3

—

(3022145) Colonoscopy Study observation

117

1.12

0.08

1.5

1.3

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

0.77

0.08

1.0

1.1

—

(3028026) IgM [Mass/volume] in Serum or Plasma

1.04

0.07

3.4

1.9

1.38

1.43

g/l

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.87

0.07

2.3

2.2

—

(3008898) HLA-B27 [Presence]

1.09

0.07

1.0

1.1

—

(3028300) Cannabinoids [Presence] in Urine

132

0.90

0.07

1.4

1.6

—

(3000764) Benzodiazepines [Presence] in Urine

132

0.90

0.07

1.4

1.6

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

102

0.87

0.06

2.1

—

10.98

—

(3027944) Amphetamines [Presence] in Urine

131

0.91

0.06

1.4

1.6

—

(3027008) Opiates [Presence] in Urine

131

0.91

0.06

1.4

1.6

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

110

1088

1.04

0.04

3.7

3.2

5.44

5.51

mmol/l

0.31

103

1019

(1001926) Buprenorphine [Presence] in Urine by Screen method

109

0.91

0.04

1.5

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

111

1101

1.03

0.02

10.1

7.8

99.13

96.65

ml/min/173m2

0.64

883

(3000492) Spirometry study

116

0.94

0.01

1.3

1.2

—

(40758558) Short blood count panel - Blood

286

1.02

0.00

5.3

5.9

—

(40768804) Tissue Pathology biopsy report

528

1.01

0.00

2.2

1.9

—

(1761868) Lipid panel - Serum or Plasma

493

0.99

0.00

1.9

2.0

—

(3023511) Choriogonadotropin [Units/volume] in Urine

115

0.95

0.00

1.1

1.3

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

168

1.01

0.00

1.4

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

0.93

0.00

1.8

1.6

—

(43055514) Macroprolactin [Presence] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

-0.00

0.0

1.6

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

-0.00

0.0

1.0

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

-0.00

0.0

1.0

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

-0.00

0.0

1.3

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

-0.00

0.0

1.0

—

(21491868) Cryoglobulin [Mass/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

-0.00

0.0

3.0

—

105.88

—

(3036535) Thyroglobulin [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

10.0

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

-0.00

0.0

2.8

—

(40760435) Tropomyosin IgE Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3035544) Cardiolipin IgG Ab [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

(3045209) Lutropin/Follitropin [Ratio] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

-0.00

0.0

1.1

—

(3025130) Human papilloma virus identified in Specimen

0.91

-0.00

1.2

1.8

—

(3028334) Neisseria gonorrhoeae [Presence] in Specimen by Organism specific culture

0.00

-0.00

0.0

1.1

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

111.80

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

-0.00

0.0

3.0

—

4.19

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(4281824) Cell count and differential, peritoneal fluid

0.00

-0.00

0.0

1.0

—

(3006462) Nitrate [Presence] in Urine

0.00

-0.00

0.0

2.3

—

(40757494) Bilirubin.total [Moles/volume] in Blood

0.00

-0.00

0.0

1.7

—

(40760888) Immunoglobulin light chains.free panel - Serum

0.00

-0.00

0.0

3.2

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

-0.00

0.0

1.1

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

-0.00

0.0

1.6

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

2.8

—

421.00

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

-0.00

0.0

1.1

—

(40761873) Peanut recombinant (rAra h) 1 IgE Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

0.06

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

-0.00

0.0

3.0

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.93

-0.00

1.3

—

(40768795) Lymph node Pathology biopsy report

0.00

-0.00

0.0

1.0

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.1

—

(3003245) Complement C1 esterase inhibitor [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.1

—

0.31

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

-0.00

0.0

1.8

—

(3042631) Mycobacterium sp identified in Specimen

0.00

-0.00

0.0

4.7

—

(3006270) Folate [Moles/volume] in Blood

0.00

-0.00

0.0

1.0

—

432.00

—

(3025378) Microscopic observation [Identifier] in Cervix by Cyto stain

0.00

-0.00

0.0

1.0

—

(3014300) Beta 2 glycoprotein 1 IgM Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.2

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

-0.00

0.0

1.7

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.2

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.7

—

(3015183) Erythrocyte sedimentation rate

0.00

-0.00

0.0

1.2

—

(3001556) Androgen free Index in Serum or Plasma

0.00

-0.00

0.0

1.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint O15_LABOUR_ANEST_COMPLIC and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_LABOUR_ANEST_COMPLIC.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: O15_LABOUR_ANEST_COMPLIC – Complications of anaesthesia during labour and delivery

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Complications of anaesthesia during labour and delivery

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints