Complications of anaesthesia during labour and delivery

O15_LABOUR_ANEST_COMPLIC

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule only females	293373
2. Check conditions None	293373
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — O74 Hospital discharge: ICD-9 — 668 Hospital discharge: ICD-8 — 6629 Cause of death: ICD-10 — O74 Cause of death: ICD-9 — 668 Cause of death: ICD-8 — 6629 2 out of 7 registries used, show all original rules.	141
4. Check minimum number of events None	141
5. Include endpoints None	141
6. Filter based on genotype QC (FinnGen only)	141

Control definitions (FinnGen only)

Control exclude: O15_COMPLIC_LAB_DELIV

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF5
Parent code in ICD-10: O60-O75
Name in latin: Complicationes ex anaesthesia intra labores/partum

NAME	O15_LABOUR_ANEST_COMPLIC
CONTROL_EXCLUDE	O15_COMPLIC_LAB_DELIV
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX	2
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	O74
HD_ICD_9	668
HD_ICD_8	6629
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	O74
COD_ICD_9	668
COD_ICD_8	6629
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Complications of anaesthesia during labour and delivery based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1122	1122	-
Only index persons	1109	1109	-
Unadjusted period prevalence (%)
Whole population	0.03	0.03	-
Only index persons	0.04	0.04	-
Median age at first event (years)
Whole population	-	29.82	-
Only index persons	-	29.87	-

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	141	141	-
Unadjusted period prevalence (%)	0.05	0.05	-
Median age at first event (years)	30.09	30.09	-

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
127: Matched controls
1269

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

O74.5

ICD-10 Finland

Spinal and epidural anaesthesia-induced headache during labour and delivery

+∞

93.7

TAB22

NOMESCO Finland

Stoppin epidural fluid escape with coagulated blood

159.6

68.8

O81.4

ICD-10 Finland

Vacuum extractor delivery

36.5

19.2

O68.0

ICD-10 Finland

Labour and delivery complicated by fetal heart rate anomaly

+∞

18.1

MAE00

NOMESCO Finland

Outlet vacuum delivery

39.1

16.3

Z34.8

ICD-10 Finland

Supervision of other normal pregnancy

4.6

13.8

205

MA2AE

NOMESCO Finland

Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus

4.4

13.0

226

O74.0

ICD-10 Finland

Aspiration pneumonitis due to anaesthesia during labour and delivery

+∞

12.7

Z39.2

ICD-10 Finland

Routine postpartum follow-up

4.5

12.7

184

Z36.3

ICD-10 Finland

Antenatal screening for malformations using ultrasound and other physical methods

3.6

10.8

380

MA2HE

NOMESCO Finland

Detailed morfological ultrasound examination of fetus

3.6

10.3

244

MCA10

NOMESCO Finland

Lower uterine segment caesarean section

5.4

9.6

W78

ICPC

Pregnancy

3.5

9.4

238

O47.0

ICD-10 Finland

False labour before 37 completed weeks of gestation

4.2

9.1

112

O99.80

ICD-10 Finland

The fear of childbirth

6.6

9.0

SPAT1379

SPAT

Health check-up of pregnant person

3.6

8.8

172

WX321

NOMESCO Finland

Acute spinal anesthesia for delivery

5.2

8.6

Z34.9

ICD-10 Finland

Supervision of normal pregnancy, unspecified

3.7

8.6

160

O72.2

ICD-10 Finland

Delayed and secondary postpartum haemorrhage

+∞

8.4

O63.1

ICD-10 Finland

Prolonged second stage (of labour)

+∞

8.4

MA2JE

NOMESCO Finland

Ultrasound screening of fetal nuchal translucency

4.0

8.4

114

WX307

NOMESCO Finland

Obstetric epidural analgesia

3.8

7.6

111

O74.8

ICD-10 Finland

Other complications of anaesthesia during labour and delivery

+∞

7.4

6688X

ICD-9 Finland

Complications of the administration of anaesthetic or other sedation in labour and delivery, Other complications of anaesthesia or other sedation in labour and delivery

+∞

7.4

O60

ICD-10 Finland

Preterm labour and delivery

+∞

7.4

O99.5

ICD-10 Finland

Diseases of the respiratory system complicating pregnancy, childbirth and the puerperium

32.0

7.2

O82.10

ICD-10 Finland

Delivery by emergency caesarean section

8.3

7.1

SPAT1197

SPAT

Extensive health check-up of expecting family

3.0

6.8

194

O70.1

ICD-10 Finland

Second degree perineal laceration during delivery

+∞

6.3

O68.8

ICD-10 Finland

Labour and delivery complicated by other evidence of fetal stress

+∞

6.3

O80.0

ICD-10 Finland

Spontaneous vertex delivery

2.6

6.3

482

WX306

NOMESCO Finland

Lumbar epidural anesthesy

4.1

6.0

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3013826) Glucose [Moles/volume] in Serum or Plasma

564

2.28

5.30

9.3

4.3

6.0

6.2

mmol/l

0.48

505

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

391

2.10

4.42

2.1

1.8

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

536

2.02

4.05

5.2

3.8

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

212

2.16

3.77

1.6

1.5

—

(3044290) Cell count panel - Cerebral spinal fluid

5.93

3.72

1.0

1.1

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

2.40

2.90

2.2

1.7

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

315

1.85

2.88

2.8

2.7

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

265

1.90

2.88

2.4

2.8

41.6

14.8

ng/l

0.72

103

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

3.23

2.87

1.4

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

100

2.29

2.76

2.0

1.5

—

(3026008) Bacteria identified in Urine by Culture

306

1.80

2.62

3.4

2.1

—

(3022806) Fractional oxyhemoglobin in Capillary blood

7.35

2.57

3.8

1.3

92.9

89.8

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

731

1.74

2.50

4.2

3.1

53.9

56.6

ug/l

0.11

685

(3047352) Trisomy 18 risk [Likelihood] in Fetus

2.21

2.46

1.5

1.4

—

(3005033) Fetal Nuchal fold Thickness US

2.21

2.46

1.5

1.4

—

(3026389) Candida sp identified in Specimen by Organism specific culture

4.27

2.39

1.4

1.5

—

(3030467) Casts [#/volume] in Urine by Automated count

256

1.79

2.33

2.6

2.4

0.2

e6/l

0.31

181

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

115

2.08

2.31

1.4

1.3

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

115

2.08

2.31

1.4

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

115

2.08

2.31

1.4

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

115

2.08

2.31

1.4

1.3

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

101

2.14

2.29

1.5

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

125

1105

2.16

2.24

4.6

4.0

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

5.71

2.23

1.0

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

3.13

2.19

1.0

1.1

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

3.13

2.19

1.1

1.3

—

(36304419) Bacteria [Presence] in Urine

261

1.74

2.17

2.6

2.4

—

(40761535) Cells panel - Urine sediment

2.40

2.15

2.5

3.3

—

(4034850)

3.33

2.13

4.1

—

(3044640) Blood type and Crossmatch panel - Blood

332

1.68

2.11

3.0

1.8

—

(3050129) First trimester maternal screen panel - Serum or Plasma

127

1.97

2.09

1.7

1.4

—

(3023410) Appearance of Cerebral spinal fluid

5.14

2.09

1.0

—

(3003694) ABO and Rh group [Type] in Blood

432

1.63

2.07

2.1

1.7

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

4.67

1.96

1.0

—

(1616796) Gas panel - Central venous blood

3.87

1.95

2.0

1.3

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

493

1.59

1.95

2.1

—

(3032080) INR in Blood by Coagulation assay

260

1.69

1.95

8.5

4.7

1.1

1.0

inr

0.34

(3018095) Leukocytes [#/volume] in Urine

356

1.63

1.94

2.8

3.1

49.8

46.7

e6/l

0.04

217

(3015736) pH of Urine

447

1.60

1.94

3.1

2.8

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.97

1.89

41.6

14.3

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

2.13

1.88

1.8

1.4

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.18

1.88

2.9

3.3

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

2.38

1.86

1.3

1.1

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

110

1.95

1.84

4.6

2.4

23.4

26.2

0.55

100

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

4.28

1.84

3.2

2.1

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

4.28

1.84

1.6

1.2

—

(3034603) RHD gene allele [Genotype] in Blood or Tissue by Molecular genetics method Nominal

3.43

1.76

1.8

1.5

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

3.43

1.76

1.2

1.3

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

3.25

1.68

2.3

2.6

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

244

1.64

1.68

3.3

2.9

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

138

1.80

1.64

3.2

2.2

3783.3

71.4

ng/l

0.46

(3029937) Albumin [Presence] in Urine by Test strip

307

1.58

1.62

5.1

3.2

0.0

estimate

0.50

124

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.78

1.60

2.0

1.2

—

(3021601) Nitrite [Presence] in Urine by Test strip

577

1.51

1.60

5.1

4.0

0.0

estimate

0.50

127

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.51

1.56

16.6

9.6

23.5

25.1

mmol/l

—

(3035350) Ketones [Presence] in Urine by Test strip

580

1.49

1.54

4.2

2.9

0.0

estimate

0.00

117

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

2.17

1.54

1.4

1.8

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

3.41

1.53

1.0

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

3.41

1.53

1.0

1.1

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.95

1.53

1.9

1.3

—

(3037467) Urinalysis macro (dipstick) panel - Urine

822

1.53

1.52

5.4

3.4

—

(3019060) Gas panel - Arterial blood

2.53

1.51

12.0

5.5

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

183

1.66

1.49

1.6

2.0

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.92

1.48

2.1

1.3

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

2.58

1.47

1.9

1.3

—

(3009261) Glucose [Presence] in Urine by Test strip

585

1.47

1.45

4.2

2.9

0.0

estimate

0.00

125

(3002582) Erythrocytes [#/volume] in Urine

279

1.55

1.45

2.6

2.7

12.5

59.8

e6/l

1.28

201

(42870588) Differential panel, method unspecified - Blood

333

1.52

1.43

9.6

5.2

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

144

1.71

1.43

2.2

2.0

0.7

1.0

e6/l

0.42

(3000991) Gas panel - Venous blood

2.27

1.40

37.2

13.0

—

(3019832) Treponema pallidum Ab [Presence] in Serum

362

1.49

1.39

1.9

1.7

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

3.01

1.37

1.4

1.1

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

2.22

1.36

1.1

1.4

—

(3001019) Free T4 and TSH panel - Serum or Plasma

130

1.72

1.36

1.7

1.4

—

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

147

1.67

1.33

1.0

1.2

101.2

173.6

iu/ml

—

(3009343) pH of Capillary blood

2.17

1.33

1.2

3.5

—

7.4

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

123

1.73

1.33

1.5

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

2.43

1.31

1.1

1.2

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

2.46

1.25

1.0

1.3

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

436

1.43

1.21

1.4

1.5

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

2.36

1.20

1.0

1.1

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

246

1.50

1.19

3.2

1.7

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

2.11

1.17

1.3

1.1

—

(3012544) pH of Venous blood

2.03

1.14

9.6

2.6

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

287

1.44

1.07

1.6

2.0

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

106

0.45

1.06

8.6

3.0

31.6

32.2

—

(3044889) 12 lead EKG panel

651

1.36

1.02

2.5

2.4

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

458

1.37

1.00

4.8

2.9

—

(3014007) Fractional oxyhemoglobin in Arterial blood

1.99

0.98

35.3

15.6

95.2

95.3

—

(3012516) Albumin [Mass/volume] in Urine

177

1.50

0.97

3.9

3.4

41.0

42.7

mg/l

0.02

118

(3025941) Bacteria identified in Stool by Culture

1.73

0.95

1.5

1.3

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.67

0.95

1.1

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

126

1183

1.61

0.94

14.6

9.4

18.8

16.9

mg/l

0.32

105

871

(3017143) Hepatitis C virus Ab [Presence] in Serum

222

1.45

0.94

2.0

1.6

—

(3001604) Monocytes [#/volume] in Blood

568

1.34

0.94

7.4

5.3

0.5

e9/l

0.39

507

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

2.12

0.90

1.7

1.5

—

(3018418) pH of Serum or Plasma

251

1.41

0.90

5.7

3.4

7.4

—

(3034770) Mitochondria Ab [Titer] in Serum

2.04

0.88

1.2

—

(40768443) Skin Pathology biopsy report

2.04

0.88

1.0

1.1

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

792

1.34

0.87

9.0

5.9

72.4

68.9

u/l

0.48

732

(36660697) Celiac disease serology panel - Serum

112

0.52

0.87

1.2

1.1

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

280

1.38

0.86

3.0

2.1

2.7

2.6

mg/l

0.01

245

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.78

0.82

2.6

1.5

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

284

1.36

0.79

2.6

1.8

0.7

0.8

mg/l

0.21

205

(3006315) Basophils [#/volume] in Blood

569

1.30

0.79

7.5

5.5

0.0

e9/l

0.65

506

(3020682) Albumin/Creatinine [Ratio] in Urine

186

1.42

0.77

4.7

4.1

5.3

9.3

mg/mmol

0.42

116

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

407

1.31

0.76

15.5

6.0

1.2

mmol/l

0.23

345

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

2.12

0.75

1.2

1.0

—

(3023368) Bacteria identified in Blood by Culture

178

1.42

0.75

4.3

3.4

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

1.89

0.75

35.1

14.8

1.5

1.3

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

1.89

0.75

35.1

14.8

0.9

0.7

—

(3042936) Bacteria identified in Isolate by Culture

135

1.47

0.74

1.9

1.8

—

(3019198) Lymphocytes [#/volume] in Blood

595

1.28

0.71

7.4

5.3

1.9

2.0

e9/l

0.30

542

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.69

0.70

1.3

1.1

—

(40768797) Stomach Pathology biopsy report

129

1.45

0.67

1.2

1.1

—

(3009542) Hematocrit [Volume Fraction] of Blood

125

1190

1.44

0.65

18.5

9.8

39.4

39.6

0.23

100

999

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

130

1.44

0.65

1.4

1.6

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

1.57

0.65

1.4

1.5

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

1.69

0.62

2.6

5.3

58.8

59.3

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

1.69

0.62

2.6

4.6

3.3

4.6

e9/l

—

(40761536) Microorganisms panel - Urine sediment

123

1.43

0.61

7.2

3.2

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

132

1.42

0.61

2.2

1.4

—

(3013115) Eosinophils [#/volume] in Blood

604

1.24

0.60

7.9

6.0

0.2

e9/l

0.56

543

(3026725) Estradiol (E2) [Moles/volume] in Serum or Plasma

1.54

0.59

1.1

1.5

0.3

0.4

nmol/l

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

387

0.78

0.57

2.6

2.0

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

427

0.79

0.55

2.7

2.1

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

226

1.30

0.53

1.4

1.8

—

(3000494) Fungus identified in Specimen by Culture

127

1.39

0.52

1.5

1.3

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

1.52

0.52

1.0

1.1

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.47

0.51

1.2

—

(3007164) IgA [Mass/volume] in Serum or Plasma

315

0.79

0.47

2.1

1.4

2.3

2.1

g/l

0.32

203

(3011288) Drugs identified in Urine by Screen method

0.62

0.44

2.7

2.0

—

(3013512) EKG study

214

0.77

0.41

4.5

2.6

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

367

1.21

0.41

2.2

1.8

96.2

93.6

pmol/l

0.19

198

(3041806) Other cells [#/volume] in Blood by Manual count

0.00

0.41

0.0

1.3

—

(3049717) Cytology report of Urine Cyto stain

0.00

0.41

0.0

1.5

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

116

1111

1.25

0.41

3.6

3.1

1.5

mmol/l

0.02

111

1057

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.41

0.0

1.2

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.41

0.0

3.1

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

0.41

0.0

1.6

—

(3013707) Erythrocyte sedimentation rate by Westergren method

843

1.19

0.40

3.6

8.8

8.3

mm/h

0.22

783

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

134

1.31

0.39

2.4

2.2

3.4

6.8

e6/l

—

(3003327) Ova and parasites identified in Stool by Light microscopy

1.35

0.38

2.1

1.7

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

117

1124

1.24

0.38

3.8

3.3

2.8

mmol/l

0.04

111

1065

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

111

1061

1.22

0.38

3.2

2.9

1.1

mmol/l

0.49

106

998

(3016879) Cocaine [Presence] in Urine

125

0.70

0.37

1.6

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

929

1.18

0.36

4.4

3.9

36.0

37.0

mmol/mol

0.62

877

(40768793) Breast Pathology biopsy report

1.41

0.35

1.7

1.2

—

(3021589) Normoblasts [#/volume] in Blood

509

1.17

0.35

10.2

7.1

0.0

e9/l

0.81

414

(3018171) Choriogonadotropin [Units/volume] in Serum or Plasma

165

1.25

0.33

2.4

2.0

930.8

5506.2

u/l

—

(3023351) European house dust mite IgE Ab [Units/volume] in Serum

1.32

0.33

1.2

1.1

—

1.1

u/ml

—

(3045414) Leukocytes [Presence] in Urine

1.32

0.33

1.5

—

(3007853) Bacteria identified in Skin by Aerobe culture

119

1.29

0.33

1.5

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

232

1.20

0.32

1.2

1.3

23.1

23.2

iu/ml

—

(4010399)

1.36

0.31

1.6

1.3

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

349

1.16

0.29

1.4

1.3

0.6

2.2

u/ml

0.84

103

(3002256) Pathology report gross observation

140

1.24

0.29

1.1

1.2

—

(4035726)

1.34

0.29

1.8

1.3

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

244

1.18

0.28

1.6

1.5

—

(3022621) pH of Urine by Test strip

1.26

0.28

2.6

2.0

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

429

1.14

0.27

2.2

1.7

—

(3024354) Oxygen [Partial pressure] in Venous blood

1.23

0.22

13.6

3.0

4.9

5.1

kpa

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.0

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.1

—

91.9

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.21

0.0

1.3

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.1

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

136

1.20

0.21

1.7

1.4

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

136

1.20

0.21

1.5

2.1

2.4

mmol/l

0.35

122

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.21

0.0

3.0

—

7.2

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.1

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(3002670) Multiple inhalant allergen IgE Ab [Units/volume] in Serum

0.00

0.20

0.0

2.9

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.20

0.0

1.2

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.20

0.0

1.2

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.20

0.0

1.2

—

(1002224) Polysomnography panel

1.18

0.18

1.3

1.0

—

(3048689) Calprotectin [Mass/mass] in Stool

206

1.14

0.17

3.1

2.6

86.6

69.6

ug/g

0.29

150

(3019225) pH of Specimen

0.71

0.17

5.6

4.3

—

(3041096) Erythrocytes [Presence] in Urine by Automated

363

1.10

0.16

4.6

2.5

—

(3020961) Endomysium IgA Ab [Titer] in Serum

1.10

0.15

1.2

1.1

—

132.0

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.80

0.15

1.6

1.3

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

103

1.18

0.14

5.1

4.3

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

106

0.84

0.13

1.6

1.5

—

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

104

1.17

0.13

3.2

2.1

35.4

60.2

u/ml

0.46

(3028300) Cannabinoids [Presence] in Urine

126

0.86

0.12

1.5

1.6

—

(3000764) Benzodiazepines [Presence] in Urine

126

0.86

0.12

1.5

1.6

—

(3027008) Opiates [Presence] in Urine

125

0.87

0.10

1.5

1.6

—

(3027944) Amphetamines [Presence] in Urine

125

0.87

0.10

1.5

1.6

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

135

0.88

0.10

1.2

1.3

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

860

1.06

0.09

5.1

2.6

28.9

29.2

u/l

0.03

819

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

1.07

0.09

2.2

1.5

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

0.79

0.08

1.0

1.1

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

225

1.08

0.08

1.1

1.2

1.0

7.6

u/ml

—

101

(3028026) IgM [Mass/volume] in Serum or Plasma

1.10

0.07

3.4

1.9

1.4

g/l

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

107

1054

1.06

0.07

3.7

3.2

5.4

5.5

mmol/l

0.31

101

988

(3008898) HLA-B27 [Presence]

0.87

0.07

1.0

1.1

—

(21494755) Public health laboratory ask at order entry panel

187

1.08

0.07

1.5

1.3

—

(40760892) CBC W Ordered Manual Differential panel - Blood

326

1.06

0.06

4.3

5.1

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

105

1062

0.96

0.04

10.6

7.8

99.0

96.2

ml/min/173m2

0.75

853

(1761868) Lipid panel - Serum or Plasma

479

1.04

0.03

1.9

2.0

—

(40768804) Tissue Pathology biopsy report

518

0.98

0.01

2.3

1.9

—

(3023511) Choriogonadotropin [Units/volume] in Urine

106

0.94

0.01

1.1

1.3

—

(3022145) Colonoscopy Study observation

116

1.04

0.00

1.5

1.3

—

(3000492) Spirometry study

109

1.01

0.00

1.3

1.2

—

(40758558) Short blood count panel - Blood

279

1.00

0.00

5.4

5.9

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

167

1.02

0.00

1.4

1.5

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

1.02

0.00

1.8

1.6

—

(3036535) Thyroglobulin [Mass/volume] in Serum or Plasma

0.00

0.0

11.5

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

0.0

1.4

—

111.8

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.0

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.90

0.00

1.3

1.4

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.0

1.0

—

(3014300) Beta 2 glycoprotein 1 IgM Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

0.0

1.3

—

(4281824)

0.00

0.0

1.0

—

(3003245) Complement C1 esterase inhibitor [Mass/volume] in Serum or Plasma

0.00

0.0

1.1

—

0.3

—

(3027231) Wheat IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

0.0

1.6

—

(21491868) Cryoglobulin [Mass/volume] in Serum

0.00

0.0

1.0

—

(43055514) Macroprolactin [Presence] in Serum or Plasma

0.00

0.0

1.0

—

(40765089) Chromosome analysis panel - Blood by G-banded

0.00

0.0

1.0

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.0

2.8

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.1

—

(40757494) Bilirubin.total [Moles/volume] in Blood

0.00

0.0

1.7

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3045209) Lutropin/Follitropin [Ratio] in Serum or Plasma

0.00

0.0

1.0

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

1.6

—

(4211845)

0.00

0.0

2.3

—

(3028334) Neisseria gonorrhoeae [Presence] in Specimen by Organism specific culture

0.00

0.0

1.3

—

(40760435) Tropomyosin IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(3015183) Erythrocyte sedimentation rate

0.00

0.0

1.2

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.0

3.0

—

4.2

—

(3042631) Mycobacterium sp identified in Specimen

0.00

0.0

4.7

—

(3025130) Human papilloma virus identified in Specimen

0.91

0.00

1.2

1.9

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.0

3.0

—

105.9

—

(3016845) Adenovirus Ag [Presence] in Specimen by Immunofluorescence

0.00

0.0

1.1

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

0.93

0.00

2.1

—

10.2

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.0

3.0

—

(3006462) Nitrate [Presence] in Urine

0.00

0.0

2.3

—

(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation

0.00

0.0

1.0

—

17.6

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.0

1.6

—

(3025378) Microscopic observation [Identifier] in Cervix by Cyto stain

0.00

0.0

1.0

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.92

0.00

2.3

2.1

—

(3022217) INR in Platelet poor plasma by Coagulation assay

0.98

0.00

32.3

12.7

—

1.2

—

(3002619) Bacteria identified in Specimen by Culture

0.00

0.0

1.0

—

(3035544) Cardiolipin IgG Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.1

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

0.0

1.2

—

(3027923) C peptide [Moles/volume] in Serum or Plasma

0.00

0.0

2.4

—

1.4

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.0

1.1

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.0

1.1

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.7

—

(40760888) Immunoglobulin light chains.free panel - Serum

0.00

0.0

3.5

—

(3010838) Calcium [Moles/time] in 24 hour Urine

0.00

0.0

1.5

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

0.0

1.8

—

5.1

—

Mortality – FinRegistry

↥

Association

Association between endpoint O15_LABOUR_ANEST_COMPLIC and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_LABOUR_ANEST_COMPLIC.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: O15_LABOUR_ANEST_COMPLIC – Complications of anaesthesia during labour and delivery

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Complications of anaesthesia during labour and delivery

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints