Complications of anaesthesia during pregnancy

O15_PREG_ANESTH_COMPL

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule only females	293373
2. Check conditions None	293373
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — O29 Cause of death: ICD-10 — O29 2 out of 7 registries used, show all original rules.	81
4. Check minimum number of events None	81
5. Include endpoints None	81
6. Filter based on genotype QC (FinnGen only)	81

Control definitions (FinnGen only)

Control exclude: O15_PREG_OTHER_MAT_DISORD

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF3
Parent code in ICD-10: O20-O29
Name in latin: Complicationes anaesthesiae in graviditate

NAME	O15_PREG_ANESTH_COMPL
CONTROL_EXCLUDE	O15_PREG_OTHER_MAT_DISORD
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX	2
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	O29
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	O29
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Complications of anaesthesia during pregnancy based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	550	550	-
Only index persons	550	550	-
Unadjusted period prevalence (%)
Whole population	0.02	0.02	-
Only index persons	0.02	0.02	-
Median age at first event (years)
Whole population	-	30.03	-
Only index persons	-	30.03	-

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	81	81	-
Unadjusted period prevalence (%)	0.03	0.03	-
Median age at first event (years)	29.71	29.71	-

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
74: Matched controls
738

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

O29.4

ICD-10 Finland

Spinal and epidural anaesthesia-induced headache during pregnancy

+∞

56.7

TAB22

NOMESCO Finland

Stoppin epidural fluid escape with coagulated blood

61.4

26.5

O24.4

ICD-10 Finland

Diabetes mellitus arising in pregnancy

185.1

25.4

O29.9

ICD-10 Finland

Complication of anaesthesia during pregnancy, unspecified

+∞

12.9

O24.9

ICD-10 Finland

Diabetes mellitus in pregnancy, unspecified

141.1

11.8

O20.9

ICD-10 Finland

Haemorrhage in early pregnancy, unspecified

38.8

10.7

O29.0

ICD-10 Finland

Pulmonary complications of anaesthesia during pregnancy

+∞

10.7

Z34.8

ICD-10 Finland

Supervision of other normal pregnancy

5.0

9.7

161

O20.0

ICD-10 Finland

Threatened abortion

+∞

9.6

MA2AE

NOMESCO Finland

Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus

4.7

9.2

176

MA2HE

NOMESCO Finland

Detailed morfological ultrasound examination of fetus

4.8

9.2

181

O47.0

ICD-10 Finland

False labour before 37 completed weeks of gestation

5.3

8.3

O21.0

ICD-10 Finland

Mild hyperemesis gravidarum

+∞

7.4

WX321

NOMESCO Finland

Acute spinal anesthesia for delivery

6.5

7.3

WX306

NOMESCO Finland

Lumbar epidural anesthesy

4.8

6.3

O24.0

ICD-10 Finland

Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent

+∞

6.3

O26.6

ICD-10 Finland

Liver disorders in pregnancy, childbirth and the puerperium

+∞

6.3

MCA10

NOMESCO Finland

Lower uterine segment caesarean section

4.0

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

3.31

3.89

1.8

1.5

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

10.53

3.02

2.0

1.6

5.0

5.3

mmol/l

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

110

2.37

2.74

2.0

—

(3045414) Leukocytes [Presence] in Urine

3.92

2.67

2.1

1.6

—

(3037467) Urinalysis macro (dipstick) panel - Urine

473

2.32

2.66

4.8

3.4

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

236

2.05

2.50

2.1

1.9

—

(3012544) pH of Venous blood

3.74

2.34

2.9

2.7

—

(3023511) Choriogonadotropin [Units/volume] in Urine

2.52

2.22

1.6

1.2

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

5.25

2.10

2.4

2.3

0.7

0.6

—

(3009261) Glucose [Presence] in Urine by Test strip

322

1.89

2.08

3.3

2.7

0.0

estimate

0.00

(3022621) pH of Urine by Test strip

3.03

2.07

2.9

2.2

—

(3035350) Ketones [Presence] in Urine by Test strip

314

1.88

2.04

3.3

2.7

0.0

estimate

0.00

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

241

1.89

2.03

3.2

2.4

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

2.33

2.01

1.8

1.4

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

133

2.02

1.97

1.9

2.5

5.5

13.6

ng/l

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

4.76

1.97

1.2

1.0

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

4.76

1.97

2.4

2.7

24.1

23.3

mmol/l

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

4.76

1.97

2.4

2.2

2.5

0.9

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

2.43

1.96

2.1

2.0

2.4

g/l

0.04

(3047826) Mullerian inhibiting substance [Mass/volume] in Serum or Plasma

0.00

1.94

0.0

1.1

—

3.3

—

(3020682) Albumin/Creatinine [Ratio] in Urine

2.26

1.89

3.0

3.5

2.6

22.5

mg/mmol

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

292

1.82

1.86

4.2

3.5

6.3

6.0

mmol/l

0.44

242

(3021447) Carbon dioxide [Partial pressure] in Venous blood

3.23

1.84

2.3

2.7

5.5

5.3

kpa

—

(3024354) Oxygen [Partial pressure] in Venous blood

3.51

1.78

2.2

2.4

5.4

5.2

kpa

—

(3000850) Epithelial cells [#/volume] in Urine

2.10

1.77

3.6

2.0

5.4

8.3

e6/l

0.60

(3021601) Nitrite [Presence] in Urine by Test strip

315

1.78

1.75

4.2

3.8

0.0

estimate

—

(3014051) Protein [Presence] in Urine by Test strip

4.02

1.74

2.8

1.6

—

(3000991) Gas panel - Venous blood

3.32

1.69

1.8

6.8

—

(1002224) Polysomnography panel

2.96

1.69

1.1

1.0

—

(3019150) Specific gravity of Urine by Refractometry

132

1.92

1.68

3.5

2.4

1.0

kg/l

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

329

1.74

1.63

4.6

3.8

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

675

2.50

1.59

11.4

8.5

16.7

17.7

mg/l

0.11

478

(3038177) Helicobacter pylori Ab [Presence] in Serum

3.48

1.54

1.0

1.1

—

(3020961) Endomysium IgA Ab [Titer] in Serum

2.61

1.53

1.1

—

(3026008) Bacteria identified in Urine by Culture

162

1.79

1.50

3.8

1.7

—

(3029937) Albumin [Presence] in Urine by Test strip

163

1.77

1.46

3.8

2.7

0.0

estimate

0.49

(3024561) Albumin [Mass/volume] in Serum or Plasma

189

1.74

1.46

3.4

3.6

36.2

37.2

g/l

0.37

180

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

216

1.71

1.44

1.5

1.7

97.3

95.2

pmol/l

0.07

124

(3032080) INR in Blood by Coagulation assay

131

1.81

1.42

2.3

4.7

1.0

inr

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

600

2.01

1.41

9.4

7.0

3.9

mmol/l

0.04

569

(3014576) Chloride [Moles/volume] in Serum or Plasma

2.73

1.39

5.3

7.2

104.2

107.3

mmol/l

—

(3002582) Erythrocytes [#/volume] in Urine

142

1.75

1.32

4.4

2.3

25.9

76.3

e6/l

0.57

102

(3007853) Bacteria identified in Skin by Aerobe culture

2.03

1.26

1.5

1.3

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

673

2.15

1.24

11.0

7.8

61.7

64.8

umol/l

1.87

673

(3021589) Normoblasts [#/volume] in Blood

282

1.57

1.17

5.9

6.8

0.0

e9/l

0.00

231

(3019550) Sodium [Moles/volume] in Serum or Plasma

600

1.83

1.16

9.6

7.0

139.2

139.4

mmol/l

0.36

575

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

2.30

1.11

1.3

1.1

—

(3000330) Specific gravity of Urine by Test strip

2.47

1.10

2.8

2.0

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

158

1.64

1.10

5.6

2.6

—

(3041096) Erythrocytes [Presence] in Urine by Automated

195

1.58

1.05

2.5

2.1

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.98

1.04

1.7

1.2

—

(3023368) Bacteria identified in Blood by Culture

101

1.73

1.03

3.4

2.9

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

1.87

1.03

3.2

2.4

0.8

mmol/l

0.19

(3015736) pH of Urine

242

1.53

1.02

3.0

2.5

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

0.00

1.00

0.0

1.6

—

1.2

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

199

1.54

0.96

1.6

1.2

0.8

0.7

u/ml

—

(3018171) Choriogonadotropin [Units/volume] in Serum or Plasma

1.74

0.95

2.9

2.2

47159.1

5336.3

u/l

—

(3042936) Bacteria identified in Isolate by Culture

1.81

0.95

1.8

1.9

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

264

1.50

0.95

1.9

1.8

—

(40766189) Gliadin peptide IgG Ab [Units/volume] in Serum by Immunoassay

2.23

0.93

1.0

—

0.9

—

(3044889) 12 lead EKG panel

336

1.45

0.85

2.9

2.1

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

1.83

0.84

1.4

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.78

0.83

1.1

1.8

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

0.00

0.80

0.0

1.7

—

0.2

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.74

0.80

1.1

1.3

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

135

1.53

0.78

3.4

2.9

—

(3034274) Bile acid [Moles/volume] in Serum --fasting

2.15

0.76

1.2

1.7

2.8

4.7

umol/l

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

2.15

0.76

1.2

1.1

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.15

0.76

2.0

1.2

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

2.06

0.74

1.6

1.2

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

2.06

0.74

1.2

1.0

—

(40761535) Cells panel - Urine sediment

2.06

0.74

4.4

3.3

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

2.06

0.74

1.2

1.0

—

(3030467) Casts [#/volume] in Urine by Automated count

128

1.52

0.74

5.0

2.3

0.0

0.4

e6/l

1.50

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

1.59

0.72

1.4

97.6

177.4

iu/ml

—

(42529406) Shigella sp [Presence] in Stool by Culture

1.98

0.72

1.2

1.1

—

(3025941) Bacteria identified in Stool by Culture

1.73

0.70

1.3

1.1

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

102

0.56

0.67

1.5

1.4

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

102

0.56

0.67

1.5

1.4

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

101

0.56

0.67

1.5

1.4

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

101

0.56

0.67

1.5

1.4

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

101

0.56

0.67

1.0

1.5

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

661

1.60

0.64

5.1

4.2

—

(36304419) Bacteria [Presence] in Urine

132

1.47

0.64

4.6

2.2

—

(3007164) IgA [Mass/volume] in Serum or Plasma

178

1.41

0.62

1.5

1.2

1.8

2.1

g/l

0.74

108

(3014133) Dog dander IgE Ab [Units/volume] in Serum

0.00

0.61

0.0

1.1

—

3.5

—

(3023430) Cat dander IgE Ab [Units/volume] in Serum

0.00

0.61

0.0

1.1

—

1.4

—

(3018095) Leukocytes [#/volume] in Urine

188

1.39

0.61

4.7

3.0

24.8

50.9

e6/l

0.46

110

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

1.77

0.59

1.7

2.5

0.2

g/l

—

(3000492) Spirometry study

1.56

0.57

1.6

1.2

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

1.49

0.54

1.4

392.2

434.5

pmol/l

0.47

(3000494) Fungus identified in Specimen by Culture

1.46

0.54

1.0

1.1

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

580

1.39

0.53

7.7

6.6

100.4

98.6

ml/min/173m2

0.37

434

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.57

0.50

1.1

1.8

—

(40760892) CBC W Ordered Manual Differential panel - Blood

177

1.33

0.47

4.2

4.4

—

(36660697) Celiac disease serology panel - Serum

1.51

0.47

1.3

1.1

—

(3003338) MCHC [Mass/volume]

640

1.39

0.44

17.6

10.6

334.3

332.8

g/l

0.79

635

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

1.65

0.44

1.8

1.7

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.41

0.0

1.1

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

0.00

0.41

0.0

1.3

—

(3003327) Ova and parasites identified in Stool by Light microscopy

1.50

0.41

1.0

1.8

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.41

0.0

2.0

—

(3005136) Cladosporium herbarum IgE Ab [Units/volume] in Serum

0.00

0.40

0.0

1.1

—

0.1

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.44

0.39

1.2

1.9

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

146

1.30

0.36

1.9

1.6

—

(3002385) Erythrocyte distribution width [Ratio]

636

1.31

0.34

12.0

10.7

13.3

13.5

0.69

628

(42870588) Differential panel, method unspecified - Blood

195

1.25

0.33

3.6

4.9

—

(40761536) Microorganisms panel - Urine sediment

1.32

0.29

4.0

2.4

—

(3009542) Hematocrit [Volume Fraction] of Blood

683

1.32

0.28

11.5

9.5

39.2

39.5

0.22

587

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.67

0.27

1.2

1.3

—

(3002256) Pathology report gross observation

1.30

0.27

1.2

1.1

—

(3019832) Treponema pallidum Ab [Presence] in Serum

248

1.20

0.26

1.8

1.7

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

181

1.22

0.26

2.3

1.8

—

(3005033) Fetal Nuchal fold Thickness US

0.72

0.25

1.5

1.4

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.71

0.25

1.5

1.4

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.70

0.25

1.5

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

1.34

0.23

1.2

3.3

172.0

227.0

u/l

—

(3021387) Prolactin [Units/volume] in Serum or Plasma

1.30

0.23

2.0

1.4

462.6

299.2

mu/l

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.30

0.23

2.0

2.1

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.23

0.22

2.2

2.5

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.23

0.22

1.4

1.2

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

0.21

0.0

1.0

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.21

0.0

1.0

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

0.00

0.21

0.0

1.3

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

0.20

0.0

1.2

—

(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence

0.00

0.20

0.0

1.6

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

168

1.17

0.18

1.4

1.5

—

(3044640) Blood type and Crossmatch panel - Blood

198

1.15

0.16

2.0

1.8

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

497

1.13

0.15

2.9

2.5

24.2

27.4

u/l

0.57

479

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

107

0.82

0.14

1.4

1.5

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.19

0.11

1.4

1.7

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.10

0.09

1.0

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

334

1.08

0.09

2.0

2.1

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

1.07

0.08

1.5

2.0

2.4

mmol/l

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

1.07

0.07

1.4

13.7

19.1

iu/l

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

1.03

0.07

1.3

1.8

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

257

1.08

0.06

1.7

1.5

—

(40758558) Short blood count panel - Blood

141

0.91

0.06

11.2

7.1

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

151

0.91

0.06

1.6

1.5

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

150

0.92

0.04

2.1

1.7

—

(1761868) Lipid panel - Serum or Plasma

260

1.06

0.04

1.4

1.8

—

(3003694) ABO and Rh group [Type] in Blood

270

1.06

0.04

1.9

1.8

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

139

0.92

0.04

2.0

1.5

—

(40768804) Tissue Pathology biopsy report

261

1.05

0.03

1.8

1.9

—

(3050129) First trimester maternal screen panel - Serum or Plasma

112

1.08

0.03

1.4

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

269

1.01

0.00

2.6

2.3

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

285

0.97

0.00

2.4

2.1

71.1

71.5

nmol/l

0.03

272

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

135

0.96

0.00

1.5

1.2

13.8

13.0

iu/ml

—

(3013512) EKG study

115

0.95

0.00

2.3

2.5

—

(21494755) Public health laboratory ask at order entry panel

115

1.05

0.00

1.3

1.2

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

246

1.02

0.00

2.4

2.1

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

0.89

0.00

1.8

1.4

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(42529201) Cancer Ag 19-9 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

5.4

—

46.2

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.0

1.2

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.1

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.0

1.4

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.0

1.4

—

(3016616) Dehydroepiandrosterone sulfate (DHEA-S) [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

8.2

—

(3006270) Folate [Moles/volume] in Blood

0.00

0.0

1.2

—

488.6

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

(4211845)

0.00

0.0

2.3

—

(3011391) Calcitriol [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

(1616796) Gas panel - Central venous blood

0.00

0.0

1.0

—

(3029396) Erythrocyte agglutination [Presence] in Blood

0.00

0.0

3.2

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

0.0

1.0

—

(3045209) Lutropin/Follitropin [Ratio] in Serum or Plasma

0.00

0.0

1.0

—

(3028286) Albumin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

40.1

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.3

—

(3043849) Epstein Barr virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

0.00

0.0

1.7

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.0

1.4

—

(3036603) Volume of Urine

0.00

0.0

1.2

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3002222) Hepatitis E virus IgM Ab [Presence] in Serum

0.00

0.0

1.0

—

(3011288) Drugs identified in Urine by Screen method

0.98

0.00

1.4

1.6

—

(3006462) Nitrate [Presence] in Urine

0.00

0.0

2.3

—

(3018921) Toxoplasma gondii IgA Ab [Units/volume] in Serum

0.00

0.0

1.4

—

(3023465) Gamma globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

8.7

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.0

3.2

—

1.3

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

0.0

1.6

—

(3006922) Hepatitis E virus Ab [Presence] in Serum

0.00

0.0

1.1

—

(3046294) Neutrophil cytoplasmic Ab.classic [Titer] in Serum

0.00

0.0

1.3

—

(3029023) Hepatitis E virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(44813793)

0.00

0.0

1.0

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.1

—

158.9

—

(21491868) Cryoglobulin [Mass/volume] in Serum

0.00

0.0

1.0

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.0

2.8

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

0.0

4.2

—

386.2

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.0

3.2

—

6.8

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.1

—

(3008898) HLA-B27 [Presence]

0.89

0.00

1.0

1.1

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.1

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.1

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.8

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.0

3.5

—

14.4

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.1

—

(3022145) Colonoscopy Study observation

0.90

0.00

1.0

1.5

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.98

0.00

1.4

1.3

—

(21494815) CD4 cells/100 lymphocytes in Specimen

0.00

0.0

2.6

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.1

—

(40760109) Toxoplasma gondii IgG Ab avidity [Ratio] in Serum by Immunoassay

0.00

0.0

1.4

—

(3016244) Insulin [Units/volume] in Serum or Plasma

0.00

0.0

4.4

—

27.1

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.0

1.0

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.0

2.8

—

104.6

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.2

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.0

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.0

2.8

—

4.0

—

(3001556) Androgen free Index in Serum or Plasma

0.00

0.0

1.2

—

(40768797) Stomach Pathology biopsy report

0.98

0.00

1.0

1.1

—

(3028679) Herpes simplex virus Ab [Presence] in Serum

0.00

0.0

1.4

—

(3023420) DNA double strand Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

1.02

0.00

2.0

1.7

—

Mortality – FinRegistry

↥

Association

Association between endpoint O15_PREG_ANESTH_COMPL and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_PREG_ANESTH_COMPL.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: O15_PREG_ANESTH_COMPL – Complications of anaesthesia during pregnancy

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Complications of anaesthesia during pregnancy

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints