Fractures involving multiple body regions

ST19_FRACT_INVOLVI_MULTIPLE_BODY_REGIONS

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — T02 Cause of death: ICD-10 — T02 2 out of 7 registries used, show all original rules.	76
4. Check minimum number of events None	76
5. Include endpoints None	76
6. Filter based on genotype QC (FinnGen only)	76

Control definitions (FinnGen only)

Control exclude: ST19_INJURI_INVOLVI_MULTIPLE_BODY_REGIONS

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: T0[0-7]
Name in latin: Fracturae regionum multarum corporis

NAME	ST19_FRACT_INVOLVI_MULTIPLE_BODY_REGIONS
CONTROL_EXCLUDE	ST19_INJURI_INVOLVI_MULTIPLE_BODY_REGIONS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	T02
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	T02
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Fractures involving multiple body regions based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	824	329	486
Only index persons	693	273	420
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.02
Median age at first event (years)
Whole population	53.75	63.34	46.96
Only index persons	52.08	60.94	46.32

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	76	28	48
Unadjusted period prevalence (%)	0.02	0.01	0.02
Median age at first event (years)	50.59	55.57	47.68

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
67: Matched controls
670

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

T02.1

ICD-10 Finland

Fractures involving thorax with lower back and pelvis

+∞

18.6

X59

ICD-10 Finland

Exposure to unspecified factor

7.4

11.8

V49.9

ICD-10 Finland

Car occupant [any] injured in unspecified traffic accident

25.7

11.8

T02.8

ICD-10 Finland

Fractures involving other combinations of body regions

+∞

11.8

S32.0

ICD-10 Finland

Fracture of lumbar vertebra

26.3

9.8

S72.3

ICD-10 Finland

Fracture of shaft of femur

35.9

9.8

T02.3

ICD-10 Finland

Fractures involving multiple regions of one lower limb

+∞

9.6

T02.9

ICD-10 Finland

Multiple fractures, unspecified

+∞

9.6

NGU20

NOMESCO Finland

Removal of internal fixation device from knee or lower leg

20.5

8.4

S22.4

ICD-10 Finland

Multiple fractures of ribs

15.7

8.3

QDB05

NOMESCO Finland

Revision of wound of skin of lower limb

28.9

7.8

X58

ICD-10 Finland

Exposure to other specified factors

6.5

7.7

S32.7

ICD-10 Finland

Multiple fractures of lumbar spine and pelvis

89.6

7.6

NCU20

NOMESCO Finland

Removal of internal fixation device from elbow or forearm

89.6

7.6

S72.1

ICD-10 Finland

Pertrochanteric fracture

23.1

7.4

T93.2

ICD-10 Finland

Sequelae of other fractures of lower limb

76.9

6.5

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

4.0

6.5

131

NCJ62

NOMESCO Finland

Internal fixation of fracture of forearm using plate

29.8

6.4

T02.2

ICD-10 Finland

Fractures involving multiple regions of one upper limb

+∞

6.3

V48.9

ICD-10 Finland

Car occupant injured in noncollision transport accident, unspecified car occupant injured in traffic accident

+∞

6.3

NEJ50

NOMESCO Finland

Operation of fracture of pelvic ring

+∞

6.3

NFJ60

NOMESCO Finland

Internal fixation of fracture of other parts of femur with intramedullary nail

17.0

6.1

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3042936) Bacteria identified in Isolate by Culture

3.34

4.73

3.9

1.7

—

(3044640) Blood type and Crossmatch panel - Blood

178

2.79

4.53

2.8

2.3

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

233

2.65

4.19

7.2

4.7

33.59

35.95

g/l

1.38

221

(3032080) INR in Blood by Coagulation assay

222

2.55

3.90

9.7

8.6

1.02

1.24

inr

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

3.36

3.32

14.6

5.1

1.23

1.22

mmol/l

0.02

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

279

2.37

3.32

4.8

4.1

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

125

2.49

3.18

3.1

2.3

—

(3000991) Gas panel - Venous blood

3.13

2.60

17.6

5.2

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

3.50

2.40

45.4

6.2

—

(3052851) Hemolysis interference index of Serum or Plasma

4.55

2.19

4.0

4.5

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

247

1.97

2.18

16.7

5.8

1.22

1.21

mmol/l

0.23

231

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

211

1.89

1.90

2.4

1.8

81.90

99.58

pmol/l

1.72

104

(3023368) Bacteria identified in Blood by Culture

152

1.96

1.88

4.8

4.4

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.30

1.84

2.1

1.6

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

207

1.84

1.74

3.4

3.1

37.81

30.68

u/l

0.33

197

(3018171) Choriogonadotropin [Units/volume] in Serum or Plasma

4.04

1.74

1.6

3.5

—

1731.98

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

264

1.78

1.66

16.5

7.1

1.22

1.21

mmol/l

0.20

226

(3049717) Cytology report of Urine Cyto stain

3.74

1.64

1.2

2.9

—

(3028026) IgM [Mass/volume] in Serum or Plasma

0.00

1.58

0.0

1.6

—

1.22

—

(3008152) Bicarbonate [Moles/volume] in Arterial blood

2.24

1.36

32.7

7.3

26.90

24.24

mmol/l

—

(3019060) Gas panel - Arterial blood

2.24

1.36

28.9

5.1

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.03

1.34

1.4

1.7

—

(3018418) pH of Serum or Plasma

168

1.73

1.33

3.7

4.3

7.41

7.40

—

(3044889) 12 lead EKG panel

416

1.69

1.29

3.7

3.6

—

(3002582) Erythrocytes [#/volume] in Urine

188

1.68

1.26

3.9

2.8

78.53

38.12

e6/l

0.41

145

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

2.74

1.23

1.4

1.8

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

226

1.63

1.20

4.4

3.5

27.17

27.15

ng/l

0.00

148

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.60

1.17

19.2

6.0

27.60

23.75

mmol/l

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

210

1.62

1.15

4.2

2.9

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.83

1.14

1.5

1.9

—

(3045414) Leukocytes [Presence] in Urine

2.36

1.05

1.8

1.4

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.98

1.02

4.0

4.1

—

(3022621) pH of Urine by Test strip

2.04

1.00

2.7

2.6

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.98

0.97

2.3

1.7

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.82

0.95

1.4

1.7

—

(3020961) Endomysium IgA Ab [Titer] in Serum

2.24

0.94

1.2

1.1

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

105

1.66

0.91

3.1

2.3

0.81

1.05

e6/l

—

(1761868) Lipid panel - Serum or Plasma

240

0.62

0.90

2.6

—

(36304419) Bacteria [Presence] in Urine

158

1.55

0.88

4.0

2.7

—

(3012544) pH of Venous blood

1.78

0.83

4.1

3.6

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.95

0.83

1.5

1.8

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

1.64

0.83

3.4

2.3

0.39

3.21

e6/l

—

(3018095) Leukocytes [#/volume] in Urine

215

1.48

0.82

4.7

3.5

133.59

36.41

e6/l

0.50

152

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

615

1.75

0.79

21.8

13.5

29.49

21.37

mg/l

1.18

476

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

0.00

0.79

0.0

2.6

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

162

1.50

0.78

2.2

3.0

1416.59

1342.32

ng/l

0.05

134

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.73

0.70

4.4

4.7

1.24

1.22

mmol/l

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.91

0.70

1.8

2.6

1.28

1.43

—

(3012516) Albumin [Mass/volume] in Urine

149

1.46

0.67

2.3

3.3

55.35

91.48

mg/l

0.39

(40761536) Microorganisms panel - Urine sediment

1.67

0.64

3.4

4.0

—

(3026008) Bacteria identified in Urine by Culture

160

1.43

0.62

3.8

3.5

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.71

0.62

1.0

1.3

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.60

0.0

1.0

—

(3002256) Pathology report gross observation

1.62

0.59

1.3

—

(3030467) Casts [#/volume] in Urine by Automated count

164

1.39

0.54

4.3

2.6

0.09

0.32

e6/l

1.20

118

(40761535) Cells panel - Urine sediment

1.58

0.54

2.7

3.1

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

650

1.67

0.53

23.8

15.3

73.25

79.27

umol/l

1.40

650

(3000494) Fungus identified in Specimen by Culture

1.54

0.50

3.0

1.3

—

(21494755) Public health laboratory ask at order entry panel

0.60

0.49

1.0

1.4

—

(36660697) Celiac disease serology panel - Serum

1.47

0.47

1.0

1.3

—

(3020682) Albumin/Creatinine [Ratio] in Urine

159

1.35

0.46

3.1

4.0

14.69

11.47

mg/mmol

0.14

107

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

124

1.37

0.43

1.2

1.4

0.44

0.95

u/ml

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.5

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

405

1.27

0.41

2.9

3.2

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

0.00

0.41

0.0

1.4

—

(40761511) CBC panel - Blood by Automated count

640

1.40

0.39

20.4

12.6

—

(3029937) Albumin [Presence] in Urine by Test strip

154

1.31

0.39

5.5

4.1

0.00

estimate

—

(4010399)

1.50

0.37

1.2

1.3

—

(3022145) Colonoscopy Study observation

1.35

0.32

1.4

—

(40768797) Stomach Pathology biopsy report

1.33

0.28

2.0

1.2

—

(42870588) Differential panel, method unspecified - Blood

199

1.22

0.28

4.9

6.0

—

(3000492) Spirometry study

1.24

0.28

1.4

1.5

—

(3002385) Erythrocyte distribution width [Ratio]

518

1.22

0.27

27.5

16.5

14.13

13.72

1.23

510

(3018677) aPTT in Platelet poor plasma by Coagulation assay

1.32

0.25

2.3

1.8

31.10

29.20

—

(3037522) Nuclear Ab [Titer] in Serum

1.32

0.25

1.5

—

693.33

—

(3037467) Urinalysis macro (dipstick) panel - Urine

398

1.19

0.25

5.6

4.7

—

(3006504) Eosinophils/100 leukocytes in Blood

280

1.18

0.24

4.7

6.1

3.27

2.71

0.33

265

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

107

1.26

0.23

1.8

2.0

367.77

499.80

pmol/l

0.95

(3019225) pH of Specimen

1.23

0.22

6.2

4.6

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.23

0.22

1.4

2.1

—

(3019069) Monocytes/100 leukocytes in Blood

282

1.17

0.21

5.1

6.5

7.58

8.76

0.94

271

(40768806) Pleura Pathology biopsy report

0.00

0.21

0.0

2.0

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.21

0.0

1.1

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.21

0.0

5.1

—

8.42

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.21

0.0

5.1

—

5.19

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.21

0.0

1.3

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.20

0.0

1.1

—

(3023421) Hepatitis B virus surface Ab [Units/volume] in Serum

0.00

0.20

0.0

2.0

—

441.00

—

(40768804) Tissue Pathology biopsy report

215

1.17

0.20

2.7

1.8

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

1.23

0.19

3.9

4.4

29.14

30.47

—

(3013512) EKG study

158

1.18

0.18

4.6

3.4

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.17

0.16

1.1

1.8

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

104

1.18

0.13

1.4

1.5

—

(3041096) Erythrocytes [Presence] in Urine by Automated

172

1.14

0.13

6.0

3.7

—

(3002030) Lymphocytes/100 leukocytes in Blood

291

1.11

0.12

4.7

6.1

26.19

27.97

0.33

278

(46235355) HIV 1 and 2 tests - Meaningful Use set

136

0.86

0.12

1.4

2.1

—

(3022096) Basophils/100 leukocytes in Blood

272

1.11

0.11

4.6

6.0

0.58

0.64

0.24

256

(3011397) Hemoglobin [Presence] in Urine by Test strip

145

0.88

0.10

3.0

3.6

—

(40758558) Short blood count panel - Blood

145

1.13

0.10

2.7

7.3

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

156

1.12

0.09

2.1

2.3

0.71

0.68

ug/l

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.77

0.08

2.6

1.3

—

(3022217) INR in Platelet poor plasma by Coagulation assay

1.05

0.08

26.7

18.5

—

1.46

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.82

0.08

1.5

1.9

—

(3000963) Hemoglobin [Mass/volume] in Blood

680

1.16

0.07

29.7

19.8

134.93

138.46

g/l

0.85

669

(3024731) MCV [Entitic volume]

680

1.16

0.07

29.6

19.6

91.33

90.90

0.36

670

(3035941) MCH [Entitic mass]

680

1.16

0.07

29.5

19.6

30.41

30.39

0.03

670

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

232

0.93

0.06

5.9

4.1

—

(3015736) pH of Urine

242

0.93

0.06

5.5

3.6

—

(3009542) Hematocrit [Volume Fraction] of Blood

579

1.08

0.05

24.1

13.7

39.09

40.95

0.59

452

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

570

0.93

0.04

19.5

12.2

89.20

84.83

ml/min/173m2

0.66

451

(3021601) Nitrite [Presence] in Urine by Test strip

301

1.05

0.03

6.7

5.6

0.00

estimate

—

(3007164) IgA [Mass/volume] in Serum or Plasma

127

0.93

0.02

1.1

1.6

1.82

2.98

g/l

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

103

0.97

0.00

1.4

1.7

—

(40760892) CBC W Ordered Manual Differential panel - Blood

143

0.97

0.00

3.4

5.6

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

213

0.98

0.00

2.7

3.4

24.74

21.56

—

(3009261) Glucose [Presence] in Urine by Test strip

305

1.03

0.00

5.2

3.9

0.00

estimate

—

(3003694) ABO and Rh group [Type] in Blood

185

0.96

0.00

1.3

1.5

—

(3035350) Ketones [Presence] in Urine by Test strip

302

0.99

0.00

5.3

3.9

0.00

estimate

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.4

—

(3047826) Mullerian inhibiting substance [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

5.43

—

(40768441) Liver Pathology biopsy report

0.00

0.0

1.0

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

0.0

1.4

—

(4027681)

0.00

0.0

1.1

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

0.00

0.0

1.1

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.3

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.0

1.1

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

0.0

1.6

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.0

2.9

—

91.27

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(3046294) Neutrophil cytoplasmic Ab.classic [Titer] in Serum

0.00

0.0

1.2

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

0.0

1.2

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.0

1.0

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(3012441) Differential panel - Pleural fluid

0.00

0.0

1.5

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.0

1.3

—

230.00

—

(3003434) Protein [Mass/volume] in Pleural fluid

0.00

0.0

1.6

—

32.16

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.3

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.0

1.2

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

0.0

1.8

—

892.83

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.6

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

0.00

0.0

3.1

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3017704) Immunofixation for Urine

0.00

0.0

1.2

—

(3044927) Protein electrophoresis panel - Urine

0.00

0.0

1.1

—

(4062490)

0.00

0.0

1.1

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.95

0.00

1.1

2.3

—

(3036782) Glucose [Moles/volume] in Pleural fluid

0.00

0.0

1.5

—

6.60

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.0

3.0

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.0

1.3

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.89

0.00

1.2

1.3

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.98

0.00

1.2

2.1

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.3

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.3

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

0.00

0.0

1.2

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.3

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

0.00

0.0

2.0

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

0.0

1.6

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

0.0

1.5

—

18.43

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.2

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.00

0.00

5.5

8.9

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.2

—

(21494434) Karyotype in Bone marrow

0.00

0.0

1.0

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.2

—

(3045788) Cell count panel - Pleural fluid

0.00

0.0

1.4

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

5.6

—

18.14

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

0.0

1.2

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint ST19_FRACT_INVOLVI_MULTIPLE_BODY_REGIONS and mortality.

Females

Parameter	HR [95% CI]	p-value
ST19_FRACT_INVOLVI_MULTIPLE_BODY_REGIONS	1.38 [0.97, 1.97]	0.075
Birth year	0.996 [0.99, 1.0]	0.376

During the follow-up period (1.1.1998 — 31.12.2019), 74 out of 246 females with ST19_FRACT_INVOLVI_MULTIPLE_BODY_REGIONS died.

Males

Parameter	HR [95% CI]	p-value
ST19_FRACT_INVOLVI_MULTIPLE_BODY_REGIONS	1.784 [1.18, 2.69]	0.006
Birth year	0.985 [0.98, 0.99]	0.002

During the follow-up period (1.1.1998 — 31.12.2019), 78 out of 369 males with ST19_FRACT_INVOLVI_MULTIPLE_BODY_REGIONS died.

Mortality risk

Mortality risk for people of age

years, who have ST19_FRACT_INVOLVI_MULTIPLE_BODY_REGIONS.

N-year risk	Females	Males
1	0.161%	0.346%
5	0.839%	2.057%
10	2.117%	4.647%
15	4.204%	8.732%
20	7.137%	14.969%

Relationships between endpoints

↥

Index endpoint: ST19_FRACT_INVOLVI_MULTIPLE_BODY_REGIONS – Fractures involving multiple body regions

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Fractures involving multiple body regions

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints