Fractures involving multiple body regions

ST19_FRACT_INVOLVI_MULTIPLE_BODY_REGIONS

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — T02 Cause of death: ICD-10 — T02 2 out of 7 registries used, show all original rules.	81
4. Check minimum number of events None	81
5. Include endpoints None	81
6. Filter based on genotype QC (FinnGen only)	79

Control definitions (FinnGen only)

Control exclude: ST19_INJURI_INVOLVI_MULTIPLE_BODY_REGIONS

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: T0[0-7]
Name in latin: Fracturae regionum multarum corporis

NAME	ST19_FRACT_INVOLVI_MULTIPLE_BODY_REGIONS
CONTROL_EXCLUDE	ST19_INJURI_INVOLVI_MULTIPLE_BODY_REGIONS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	T02
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	T02
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Fractures involving multiple body regions based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	824	329	486
Only index persons	693	273	420
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.02
Median age at first event (years)
Whole population	53.75	63.34	46.96
Only index persons	52.08	60.94	46.32

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	79	28	51
Unadjusted period prevalence (%)	0.02	0.01	0.02
Median age at first event (years)	54.29	61.38	50.39

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
81: Matched controls
810

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

T02.1

ICD-10 Finland

Fractures involving thorax with lower back and pelvis

+∞

25.3

X59

ICD-10 Finland

Exposure to unspecified factor

7.0

17.2

104

S32.0

ICD-10 Finland

Fracture of lumbar vertebra

21.1

11.8

T02.3

ICD-10 Finland

Fractures involving multiple regions of one lower limb

+∞

11.7

T02.9

ICD-10 Finland

Multiple fractures, unspecified

+∞

11.7

T02.8

ICD-10 Finland

Fractures involving other combinations of body regions

+∞

11.7

S22.4

ICD-10 Finland

Multiple fractures of ribs

30.1

11.6

ZXD05

NOMESCO Finland

Urgent procedure

4.9

11.6

158

S72.3

ICD-10 Finland

Fracture of shaft of femur

125.6

10.7

ZXE20

NOMESCO Finland

More than three and less than five hours

5.9

10.6

V49.9

ICD-10 Finland

Car occupant [any] injured in unspecified traffic accident

16.2

10.2

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

4.4

10.0

166

X58

ICD-10 Finland

Exposure to other specified factors

5.0

9.5

S32.7

ICD-10 Finland

Multiple fractures of lumbar spine and pelvis

41.8

9.3

NGU20

NOMESCO Finland

Removal of internal fixation device from knee or lower leg

27.8

9.2

NFJ60

NOMESCO Finland

Internal fixation of fracture of other parts of femur with intramedullary nail

100.0

8.6

NEJ50

NOMESCO Finland

Operation of fracture of pelvic ring

+∞

8.5

T93.2

ICD-10 Finland

Sequelae of other fractures of lower limb

+∞

8.5

T02.2

ICD-10 Finland

Fractures involving multiple regions of one upper limb

+∞

8.5

T81.4

ICD-10 Finland

Infection following a procedure, not elsewhere classified

5.2

8.0

NCU20

NOMESCO Finland

Removal of internal fixation device from elbow or forearm

87.8

7.6

T02.7

ICD-10 Finland

Fractures involving thorax with lower back and pelvis with limb(s)

+∞

7.4

S72.1

ICD-10 Finland

Pertrochanteric fracture

18.7

6.9

WX700

NOMESCO Finland

Respiratory and circulatory monitoring

4.1

6.9

NGJ62

NOMESCO Finland

Internal fixation of fracture of knee or lower leg using plate and screws, other or unspecified

75.6

6.5

T90.5

ICD-10 Finland

Sequelae of intracranial injury

29.2

6.4

S82.3

ICD-10 Finland

Fracture of lower end of tibia

29.2

6.4

NGJ70

NOMESCO Finland

External fixation of fracture of knee or lower leg, other or unspecified

+∞

6.3

ZZA00

NOMESCO Finland

Split skin graft

11.3

6.3

NH1AA

NOMESCO Finland

Ankle X-ray examination without contrast

7.9

6.0

NE1AA

NOMESCO Finland

Pelvis X-ray examination

7.1

6.0

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3042936) Bacteria identified in Isolate by Culture

3.84

6.46

3.7

1.7

—

(3044640) Blood type and Crossmatch panel - Blood

188

2.92

5.25

2.8

2.3

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

244

2.90

5.24

6.8

4.8

33.14

36.03

g/l

2.03

230

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

293

2.70

4.52

3.0

2.5

—

(3022217) INR in Platelet poor plasma by Coagulation assay

283

2.45

3.78

12.8

12.2

1.01

1.31

inr

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

133

2.55

3.55

2.9

2.2

—

(3000991) Gas panel - Venous blood

3.67

3.33

15.1

5.1

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

3.10

2.98

14.6

4.8

1.23

1.24

mmol/l

0.02

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

224

2.09

2.63

2.4

1.8

86.25

98.63

pmol/l

1.11

109

(3007853) Bacteria identified in Skin by Aerobe culture

2.52

2.47

2.1

1.6

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

3.24

2.22

45.4

5.9

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

2.34

2.14

4.7

6.4

1.06

1.03

mmol/l

0.23

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

268

1.88

2.03

16.2

5.6

1.22

1.21

mmol/l

0.11

249

(3023368) Bacteria identified in Blood by Culture

164

1.97

2.02

5.1

4.2

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

4.76

1.97

1.8

1.4

—

(3052851) Hemolysis interference index of Serum or Plasma

3.72

1.87

4.0

—

(3002582) Erythrocytes [#/volume] in Urine

202

1.87

3.7

2.9

78.50

36.26

e6/l

0.52

157

(3021901) Oxygen saturation in Capillary blood

4.36

1.85

2.8

2.3

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

284

1.81

1.83

15.9

7.0

1.22

1.21

mmol/l

0.03

244

(3026008) Bacteria identified in Urine by Culture

173

1.84

1.70

3.9

3.4

—

(3049717) Cytology report of Urine Cyto stain

3.73

1.64

1.2

2.9

—

(3028026) IgM [Mass/volume] in Serum or Plasma

0.00

1.55

0.0

1.6

—

1.20

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.11

1.55

1.4

1.7

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.98

1.53

1.5

1.9

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

223

1.72

1.50

3.3

29.16

30.08

u/l

0.13

212

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

2.64

1.49

26.6

6.5

25.00

25.23

mmol/l

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.47

1.48

2.3

1.7

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

243

1.69

1.44

4.7

3.5

25.98

26.53

ng/l

0.03

162

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

642

2.09

1.39

22.7

13.6

28.92

21.60

mg/l

1.10

500

(3022313) Gas panel - Capillary blood

2.73

1.39

2.2

3.0

—

(3044889) 12 lead EKG panel

442

1.67

1.31

3.6

—

(3018095) Leukocytes [#/volume] in Urine

230

1.65

1.31

4.4

3.6

115.16

34.72

e6/l

0.49

164

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

221

1.65

1.31

4.1

3.0

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

110

1.82

1.29

3.0

2.3

0.74

0.98

e6/l

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

2.73

1.23

1.4

1.8

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

104

1.80

1.21

3.2

2.4

0.38

2.87

e6/l

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.04

1.18

4.0

3.9

—

(3023465) Gamma globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.59

1.17

1.2

1.1

10.82

11.04

g/l

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.90

1.15

1.4

1.7

—

(3030467) Casts [#/volume] in Urine by Automated count

174

1.63

1.14

4.0

2.6

0.24

0.30

e6/l

0.15

127

(3018418) pH of Serum or Plasma

184

1.61

1.11

3.7

4.3

7.40

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.47

1.10

19.2

5.7

27.60

23.95

mmol/l

—

(3019060) Gas panel - Arterial blood

2.12

1.09

28.9

5.0

—

(36304419) Bacteria [Presence] in Urine

167

1.62

1.09

3.9

2.7

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.22

1.08

1.4

1.8

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.22

1.08

1.0

1.2

—

(3005229) Alpha 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.35

1.05

1.2

8.62

7.82

g/l

—

(3043747) Beta 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.35

1.05

1.2

4.22

3.76

g/l

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.35

1.05

1.2

—

(3000494) Fungus identified in Specimen by Culture

1.87

1.03

2.7

1.3

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

683

1.96

0.99

24.9

15.4

73.81

79.65

umol/l

1.43

683

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.23

0.93

3.7

2.5

1.08

1.40

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

2.23

0.93

3.7

2.5

0.65

0.69

—

(3020961) Endomysium IgA Ab [Titer] in Serum

2.08

0.89

1.2

1.1

—

(3045414) Leukocytes [Presence] in Urine

2.25

0.77

1.8

1.3

—

(3022621) pH of Urine by Test strip

1.87

0.75

2.7

2.5

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.69

0.69

1.3

2.1

—

(40761511) CBC panel - Blood by Automated count

673

1.63

0.68

21.3

12.6

—

(3025941) Bacteria identified in Stool by Culture

1.77

0.65

1.2

1.3

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.70

0.64

4.0

4.4

1.24

1.22

mmol/l

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

1.71

0.62

8.8

3.3

50.20

54.72

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.61

0.0

1.0

—

(3037467) Urinalysis macro (dipstick) panel - Urine

420

1.35

0.61

5.9

4.6

—

(40761536) Microorganisms panel - Urine sediment

1.56

0.60

3.4

3.9

—

(3012516) Albumin [Mass/volume] in Urine

161

1.41

0.60

2.3

3.3

51.86

85.68

mg/l

0.39

104

(3002385) Erythrocyte distribution width [Ratio]

555

1.40

0.59

28.0

16.4

15.55

14.45

0.73

549

(1761868) Lipid panel - Serum or Plasma

252

0.73

0.55

2.6

2.7

—

(3006504) Eosinophils/100 leukocytes in Blood

296

1.32

0.54

4.7

6.1

3.35

2.71

0.44

283

(3019069) Monocytes/100 leukocytes in Blood

298

1.31

0.51

5.1

6.5

7.65

8.70

0.92

288

(21494755) Public health laboratory ask at order entry panel

0.59

0.49

1.0

1.4

—

(36660697) Celiac disease serology panel - Serum

1.44

0.46

1.0

1.3

—

(3022096) Basophils/100 leukocytes in Blood

285

1.27

0.42

4.6

6.0

0.63

0.01

271

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.41

0.0

1.1

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.5

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

0.00

0.41

0.0

1.4

—

(3002030) Lymphocytes/100 leukocytes in Blood

306

1.25

0.40

4.7

6.1

25.38

27.82

0.54

294

(3002256) Pathology report gross observation

1.44

0.39

1.3

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

426

1.25

0.38

2.8

3.1

—

(3000492) Spirometry study

1.32

0.38

1.3

1.5

—

(3020682) Albumin/Creatinine [Ratio] in Urine

173

1.29

0.38

3.0

3.8

13.74

10.74

mg/mmol

0.14

116

(40760892) CBC W Ordered Manual Differential panel - Blood

299

1.24

0.36

5.1

6.9

—

(3019225) pH of Specimen

1.39

0.35

5.3

4.3

—

(4200892) Spirometry reversibility

1.33

0.34

1.2

1.3

—

(40758558) Short blood count panel - Blood

148

1.28

0.33

2.7

7.3

—

(40768797) Stomach Pathology biopsy report

1.32

0.30

1.9

1.2

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

131

1.28

0.30

1.2

1.4

0.44

0.95

u/ml

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.69

0.27

1.2

1.9

—

(3041096) Erythrocytes [Presence] in Urine by Automated

182

1.21

0.24

6.5

3.6

—

(3000963) Hemoglobin [Mass/volume] in Blood

716

1.39

0.24

31.1

19.7

133.61

138.67

g/l

1.51

701

(3035941) MCH [Entitic mass]

716

1.39

0.24

30.9

19.5

30.47

30.43

0.07

703

(3024731) MCV [Entitic volume]

716

1.39

0.24

31.0

19.5

91.52

91.00

0.47

703

(40761535) Cells panel - Urine sediment

1.27

0.23

3.0

3.2

—

(3018301) Testosterone Free [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

195.80

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(40768806) Pleura Pathology biopsy report

0.00

0.21

0.0

2.0

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.21

0.0

5.1

—

5.19

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.21

0.0

5.1

—

8.42

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.21

0.0

1.3

—

(4062490) Immunoglobulin typing, IgG

0.00

0.21

0.0

1.1

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.21

0.0

1.1

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.21

0.0

1.3

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.6

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.21

0.0

1.1

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.21

0.0

1.3

—

(40768804) Tissue Pathology biopsy report

224

1.17

0.20

2.6

1.9

—

(3029937) Albumin [Presence] in Urine by Test strip

166

1.19

0.20

5.5

4.0

0.00

estimate

—

(3023421) Hepatitis B virus surface Ab [Units/volume] in Serum

0.00

0.20

0.0

2.0

—

365.20

—

(3013512) EKG study

167

1.18

0.19

5.7

3.4

—

(3022145) Colonoscopy Study observation

1.25

0.19

1.4

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

1.14

0.18

3.6

4.6

29.86

30.32

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.71

0.17

2.6

1.4

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.78

0.16

1.2

2.2

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.17

0.16

1.1

1.8

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

139

0.84

0.15

1.4

2.0

—

(3021601) Nitrite [Presence] in Urine by Test strip

318

1.12

0.14

7.6

5.4

0.00

estimate

—

(3009261) Glucose [Presence] in Urine by Test strip

322

1.10

0.10

5.4

3.9

0.00

estimate

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

224

1.10

0.09

3.2

3.5

23.06

21.71

0.27

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.78

0.08

1.2

2.1

—

(3015736) pH of Urine

265

1.09

0.08

5.8

3.6

6.10

5.70

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

108

1.13

0.08

1.4

1.5

—

(3007164) IgA [Mass/volume] in Serum or Plasma

132

0.89

0.07

1.1

1.6

1.82

2.96

g/l

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

152

0.90

0.07

2.9

3.5

—

(3035350) Ketones [Presence] in Urine by Test strip

320

1.05

0.04

5.5

3.9

0.00

estimate

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

162

1.06

0.02

2.1

2.4

0.71

0.68

ug/l

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

246

0.97

0.00

6.3

4.0

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

102

0.98

0.00

1.4

1.7

—

(3003694) ABO and Rh group [Type] in Blood

188

1.01

0.00

1.3

1.5

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

604

0.97

0.00

20.4

12.2

87.14

83.95

ml/min/173m2

0.45

477

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.97

-0.00

5.5

9.1

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

3.1

—

(3036782) Glucose [Moles/volume] in Pleural fluid

0.00

-0.00

0.0

1.4

—

6.53

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

-0.00

0.0

1.6

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

-0.00

0.0

1.6

—

(3036535) Thyroglobulin [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

4.2

—

(3046294) Neutrophil cytoplasmic Ab.classic [Titer] in Serum

0.00

-0.00

0.0

1.2

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

-0.00

0.0

1.3

—

230.00

—

(40768441) Liver Pathology biopsy report

0.00

-0.00

0.0

1.0

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.3

—

(3003434) Protein [Mass/volume] in Pleural fluid

0.00

-0.00

0.0

1.6

—

32.16

—

(3044927) Protein electrophoresis panel - Urine

0.00

-0.00

0.0

1.1

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

-0.00

0.0

1.2

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.7

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.3

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

-0.00

0.0

1.2

—

(3000034) Microalbumin [Mass/volume] in Urine

0.00

-0.00

0.0

3.8

—

31.92

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.8

—

(3007798) IgG/Albumin [Mass Ratio] in Cerebral spinal fluid

0.00

-0.00

0.0

1.5

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

4.3

—

12.95

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

-0.00

0.0

1.0

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.1

—

(21494434) Karyotype in Bone marrow

0.00

-0.00

0.0

1.0

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

-0.00

0.0

1.3

—

(3028167) CD3+CD4+ (T4 helper) cells [#/volume] in Blood

0.00

-0.00

0.0

3.0

—

413.83

—

(3045788) Cell count panel - Pleural fluid

0.00

-0.00

0.0

1.4

—

(3005570) Glucose [Moles/volume] in Urine

0.00

-0.00

0.0

2.6

—

(21494815) CD4 cells/100 lymphocytes in Specimen

0.00

-0.00

0.0

1.8

—

42.66

—

(3000012) Reticulocyte production index

0.00

-0.00

0.0

1.6

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

-0.00

0.0

1.4

—

(3012441) Differential panel - Pleural fluid

0.00

-0.00

0.0

1.5

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

-0.00

0.0

1.1

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

-0.00

0.0

1.2

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.7

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

0.00

-0.00

0.0

1.1

—

(3047826) Mullerian inhibiting substance [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

6.81

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.3

—

(3017704) Immunofixation for Urine

0.00

-0.00

0.0

1.2

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

-0.00

0.0

2.9

—

91.27

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

-0.00

0.0

1.0

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

-0.00

0.0

1.5

—

18.43

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

-0.00

0.0

1.2

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.3

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.8

—

892.83

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.90

-0.00

1.2

—

(3011391) Calcitriol [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint ST19_FRACT_INVOLVI_MULTIPLE_BODY_REGIONS and mortality.

Females

Parameter	HR [95% CI]	p-value
ST19_FRACT_INVOLVI_MULTIPLE_BODY_REGIONS	1.38 [0.97, 1.97]	0.075
Birth year	0.996 [0.99, 1.0]	0.376

During the follow-up period (1.1.1998 — 31.12.2019), 74 out of 246 females with ST19_FRACT_INVOLVI_MULTIPLE_BODY_REGIONS died.

Males

Parameter	HR [95% CI]	p-value
ST19_FRACT_INVOLVI_MULTIPLE_BODY_REGIONS	1.784 [1.18, 2.69]	0.006
Birth year	0.985 [0.98, 0.99]	0.002

During the follow-up period (1.1.1998 — 31.12.2019), 78 out of 369 males with ST19_FRACT_INVOLVI_MULTIPLE_BODY_REGIONS died.

Mortality risk

Mortality risk for people of age

years, who have ST19_FRACT_INVOLVI_MULTIPLE_BODY_REGIONS.

N-year risk	Females	Males
1	0.161%	0.346%
5	0.839%	2.057%
10	2.117%	4.647%
15	4.204%	8.732%
20	7.137%	14.969%

Relationships between endpoints

↥

Index endpoint: ST19_FRACT_INVOLVI_MULTIPLE_BODY_REGIONS – Fractures involving multiple body regions

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Fractures involving multiple body regions

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints