Granulosa cell carcinoma of ovary, excluding all cancers (controls excluding all cancers)

C3_OVARY_GRANULOSA_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

only females

293373

2. Check conditions

None

293373

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cancer registry: Topography ICD-O-3 C56
  • Cancer registry: Morphology ICD-O-3 8620
  • Cancer registry: Behaviour codes 3

1 out of 7 registries used, show all original rules.

101

4. Check minimum number of events

None

101

5. Include endpoints

None

101

6. Filter based on genotype QC (FinnGen only)

101

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12

Similar endpoints

List of similar endpoints to Granulosa cell carcinoma of ovary, excluding all cancers (controls excluding all cancers) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 101 101 -
Unadjusted period prevalence (%) 0.03 0.03 -
Median age at first event (years) 55.36 55.36 -

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
96
Matched controls
960
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
8620/3-C56.9
ICD-O-3
Adult granulosa cell tumor of ovary of ovary
+∞
138.3
96
*
C56.92
ICD-10 Finland
Malignant ovarian tumor, sex chord stroma derived
+∞
111.2
84
*
D39.10
ICD-10 Finland
Tumor of uncertain or unknown nature in the ovary without histology
69.6
43.8
49
14
B01AB10
ATC
tinzaparin; parenteral
39.8
34.1
43
19
JN4BD
NOMESCO Finland
Extensive body CT
42.9
27.8
34
12
128
Kela drug reimbursment
Cancers of female genital organs
+∞
27.4
25
*
JAL31
NOMESCO Finland
Laparoscopic omentectomy
333.2
26.0
25
*
LAF11
NOMESCO Finland
Laparoscopic bilateral salpingo-oophorectomy
22.3
24.2
36
25
B01AB05
ATC
enoxaparin; parenteral
9.5
22.4
61
149
H02AB02
ATC
dexamethasone; systemic
93.8
20.7
22
*
C56.91
ICD-10 Finland
Malignant granulosa cell tumor in ovary
+∞
20.5
19
*
JAL30
NOMESCO Finland
Omentectomy
249.3
20.4
20
*
JAL00
NOMESCO Finland
Biopsy of peritoneum
233.8
19.3
19
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
42.5
19.0
23
7
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
7.5
18.6
70
252
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
14.1
16.1
28
27
LAF01
NOMESCO Finland
Laparoscopic unilateral salpingo-oophorectomy
18.4
15.6
24
17
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
7.6
15.4
41
85
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
15.0
14
*
WX402
NOMESCO Finland
General anaesthesia
8.4
14.9
36
64
R19.0
ICD-10 Finland
Intra-abdominal and pelvic swelling, mass and lump
19.9
14.8
22
14
LAF10
NOMESCO Finland
Bilateral salpingo-oophorectomy
22.0
14.6
21
12
JAL01
NOMESCO Finland
Laparoscopic biopsy of peritoneum
87.6
14.0
15
*
LCD01
NOMESCO Finland
Total laparoscopic hysterectomy
25.9
14.0
19
9
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
27.2
13.5
18
8
LX1XE
NOMESCO Finland
Other gynecological ultrasound examination
19.8
12.2
18
11
LCD00
NOMESCO Finland
Hysterectomy
11.3
12.1
23
26
JN4AD
NOMESCO Finland
Body CT examination
20.3
11.7
17
10
C56.00
ICD-10 Finland
Malignant tumor of the ovary without histology
+∞
11.7
11
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
5.4
11.4
40
112
A04AA01
ATC
ondansetron; systemic, rectal
16.9
11.0
17
12
JAL20
NOMESCO Finland
Excision or destruction of lesion of peritoneum
122.9
10.6
11
*
L03AA13
ATC
pegfilgrastim; parenteral
+∞
10.6
10
*
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
12.7
10.3
18
17
LCD04
NOMESCO Finland
Laparoscopic hysterectomy
8.9
10.2
22
31
TPH07
NOMESCO Finland
Cathetrisation of artery
11.2
9.2
17
18
ZXE20
NOMESCO Finland
More than three and less than five hours
6.7
8.9
23
43
HA1AA
NOMESCO Finland
X-ray mammography
11.0
8.7
16
17
A03FA01
ATC
metoclopramide; systemic, rectal
4.6
8.6
33
98
ZXE10
NOMESCO Finland
More than one and less than three hours
3.7
8.5
51
225
A04AA02
ATC
granisetron; systemic, transdermal
+∞
8.4
8
*
115
Kela drug reimbursment
Breast cancer
+∞
8.4
8
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
8.4
8
*
LAF16
NOMESCO Finland
Excision of uterus, adnexes and lymph nodes for treatment of ovarian cancer
+∞
8.4
8
*
L02BG04
ATC
letrozole; oral
27.6
7.7
10
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
+∞
7.4
7
*
L02BA01
ATC
tamoxifen; oral
+∞
7.4
7
*
A04AA55
ATC
palonosetron, combinations; systemic
+∞
7.4
7
*
JEA00
NOMESCO Finland
Appendectomy
7.1
7.2
17
28
JAP00
NOMESCO Finland
Freeing of adhesions in the peritoneal cavity
24.5
6.8
9
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
3.5
6.8
38
152
WC125
NOMESCO Finland
Demanding cytostatic therapy of local tumor recidive
+∞
6.3
6
*
L03AA14
ATC
lipegfilgrastim; parenteral
+∞
6.3
6
*
PJA12
NOMESCO Finland
Sentinel node biopsy
+∞
6.3
6
*
LC2DE
NOMESCO Finland
Demanding ultrsound examination of uterus, parametrium and lower part of abdomen with speciel methods
6.0
6.0
16
31

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: C3_OVARY_GRANULOSA_EXALLC – Granulosa cell carcinoma of ovary, excluding all cancers (controls excluding all cancers)

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).