Adenocarcinoma of small intestine, excluding all cancers (controls excluding all cancers)

C3_SMALL_INTESTINE_ADENO_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cancer registry: Topography ICD-O-3 C17
  • Cancer registry: Morphology ICD-O-3 8140|8144|8145
  • Cancer registry: Behaviour codes 3

1 out of 7 registries used, show all original rules.

87

4. Check minimum number of events

None

87

5. Include endpoints

None

87

6. Filter based on genotype QC (FinnGen only)

87

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12

Similar endpoints

List of similar endpoints to Adenocarcinoma of small intestine, excluding all cancers (controls excluding all cancers) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 87 37 50
Unadjusted period prevalence (%) 0.02 0.01 0.02
Median age at first event (years) 68.91 65.83 71.18

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
83
Matched controls
830
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
130
Kela drug reimbursment
Malignant tumour
+∞
65.5
54
*
8140/3-C17.0
ICD-O-3
Adenocarcinoma, NOS, of duodenum
+∞
42.4
37
*
L01BC06
ATC
capecitabine; oral
+∞
42.4
37
*
C17.0
ICD-10 Finland
Malignant neoplasm: Duodenum
+∞
34.9
31
*
H02AB02
ATC
dexamethasone; systemic
188.0
34.8
34
*
A03FA01
ATC
metoclopramide; systemic, rectal
22.1
29.5
47
46
JFB00
NOMESCO Finland
Partial resection of small intestine
115.1
29.1
30
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
98.2
25.6
27
*
D37.2
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Small intestine
+∞
25.3
23
*
A04AA02
ATC
granisetron; systemic, transdermal
331.9
25.1
24
*
JLC30
NOMESCO Finland
Pancreatoduodenectomy
+∞
24.1
22
*
8140/3-C17.9
ICD-O-3
Adenocarcinoma, NOS, of small intestine, NOS
+∞
23.0
21
*
C17.1
ICD-10 Finland
Malignant neoplasm: Jejunum
+∞
23.0
21
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
21.8
20
*
C17.9
ICD-10 Finland
Malignant neoplasm: Small intestine, unspecified
+∞
21.8
20
*
A09AA02
ATC
multienzymes (lipase, protease etc.)
80.8
17.6
19
*
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
17.3
16
*
C17.2
ICD-10 Finland
Malignant neoplasm: Ileum
+∞
17.3
16
*
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
23.5
16.9
24
14
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
45.2
15.2
18
5
133
Kela drug reimbursment
Severe chronic pancreatic insufficiency
180.5
15.0
15
*
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
22.9
14.8
21
12
A04AA01
ATC
ondansetron; systemic, rectal
52.5
14.8
17
*
JN4AD
NOMESCO Finland
Body CT examination
25.8
14.6
20
10
Z51.5
ICD-10 Finland
Palliative care
32.2
14.1
18
7
8140/3-C17.2
ICD-O-3
Adenocarcinoma, NOS, of ileum
+∞
13.9
13
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
6.1
13.4
50
165
JN4BD
NOMESCO Finland
Extensive body CT
14.0
13.3
23
22
JAH00
NOMESCO Finland
Laparotomy
36.0
12.1
15
5
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
+∞
11.7
11
*
8140/3-C17.1
ICD-O-3
Adenocarcinoma, NOS, of jejunum
+∞
11.7
11
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
+∞
11.7
11
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
11.3
11.1
21
24
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
10.6
10
*
JN3AD
NOMESCO Finland
Abdominal CT examination
10.0
10.4
21
27
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
20.0
10.3
15
9
N02AA05
ATC
oxycodone; systemic
6.2
10.2
30
69
TPX10
NOMESCO Finland
Implantation of vascular injection port
30.4
10.2
13
5
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
10.2
10.1
20
25
JN3BD
NOMESCO Finland
Extensive abdominal CT
7.6
9.9
24
42
D13.2
ICD-10 Finland
Benign neoplasm: Duodenum
41.7
9.3
11
*
B01AB10
ATC
tinzaparin; parenteral
12.1
9.0
16
16
UJF92
NOMESCO Finland
Capsular endoscopy
56.1
8.9
10
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
4.7
8.9
36
117
C17.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of small intestine
+∞
8.5
8
*
WX408
NOMESCO Finland
General anesthesy, balanced
4.4
8.0
33
107
WX402
NOMESCO Finland
General anaesthesia
5.9
7.6
22
48
UJF32
NOMESCO Finland
Coloscopy
4.1
7.6
37
137
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
87.6
7.5
8
*
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
+∞
7.4
7
*
C25.0
ICD-10 Finland
Malignant neoplasm: Head of pancreas
+∞
7.4
7
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
7.4
7
*
Z80.0
ICD-10 Finland
Family history of malignant neoplasm of digestive organs
+∞
7.4
7
*
WW500
NOMESCO Finland
Blood transfusion
22.4
7.3
10
5
R4190
NOMESCO Finland
Nutritional therapy
33.2
7.3
9
*
TPH07
NOMESCO Finland
Cathetrisation of artery
5.8
7.3
21
46
JAH01
NOMESCO Finland
Laparoscopy
15.6
7.1
11
8
A02BC02
ATC
pantoprazole; systemic
3.8
6.9
65
402
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
3.5
6.7
40
174
ZXE20
NOMESCO Finland
More than three and less than five hours
5.4
6.6
20
46
R11
ICD-10 Finland
Nausea and vomiting
6.8
6.6
16
28
K83.1
ICD-10 Finland
Obstruction of bile duct
+∞
6.3
6
*
A04AA55
ATC
palonosetron, combinations; systemic
+∞
6.3
6
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
6.3
6
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
+∞
6.3
6
*
C78.6
ICD-10 Finland
Secondary malignant neoplasm of retroperitoneum and peritoneum
+∞
6.3
6
*
JDE00
NOMESCO Finland
Gastrojejunostomy
+∞
6.3
6
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
6.3
6
*
WB121
NOMESCO Finland
Demanding neoadjuvant cytostatic therapy
+∞
6.3
6
*
D64.9
ICD-10 Finland
Anaemia, unspecified
4.5
6.1
22
61
TPH04
NOMESCO Finland
Cathetrisation of vein
3.9
6.0
27
92

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: C3_SMALL_INTESTINE_ADENO_EXALLC – Adenocarcinoma of small intestine, excluding all cancers (controls excluding all cancers)

GWS hits: 1

This endpoint is excluded (different definition than used in FinnGen).