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Adenocarcinoma of small intestine

C3_SMALL_INTESTINE_ADENO

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cancer registry: Topography ICD-O-3 C17
  • Cancer registry: Morphology ICD-O-3 8140|8144|8145
  • Cancer registry: Behaviour codes 3

1 out of 7 registries used, show all original rules.

87

4. Check minimum number of events

None

87

5. Include endpoints

None

87

6. Filter based on genotype QC (FinnGen only)

87

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze
DF8

Similar endpoints

List of similar endpoints to Adenocarcinoma of small intestine based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 87 37 50
Unadjusted period prevalence (%) 0.02 0.01 0.02
Median age at first event (years) 68.91 65.83 71.18

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
83
Matched controls
828
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
8140/3-C17.0
ICD-O-3
Adenocarcinoma, NOS, of duodenum
+∞
42.4
37
*
130
Kela drug reimbursment
Malignant tumour
32.1
37.7
54
45
C17.0
ICD-10 Finland
Malignant neoplasm: Duodenum
485.4
33.4
31
*
L01BC06
ATC
capecitabine; oral
40.4
29.6
37
16
JFB00
NOMESCO Finland
Partial resection of small intestine
45.9
25.0
30
10
D37.2
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Small intestine
312.9
23.9
23
*
8140/3-C17.9
ICD-O-3
Adenocarcinoma, NOS, of small intestine, NOS
+∞
23.0
21
*
JLC30
NOMESCO Finland
Pancreatoduodenectomy
294.5
22.8
22
*
C17.1
ICD-10 Finland
Malignant neoplasm: Jejunum
276.6
21.7
21
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
30.0
20.3
27
13
C17.9
ICD-10 Finland
Malignant neoplasm: Small intestine, unspecified
86.4
18.7
20
*
A03FA01
ATC
metoclopramide; systemic, rectal
8.3
17.0
47
112
H02AB02
ATC
dexamethasone; systemic
11.5
16.9
34
47
C17.2
ICD-10 Finland
Malignant neoplasm: Ileum
195.3
16.1
16
*
A09AA02
ATC
multienzymes (lipase, protease etc.)
34.6
15.1
19
7
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
19.6
14.0
21
14
8140/3-C17.2
ICD-O-3
Adenocarcinoma, NOS, of ileum
+∞
13.9
13
*
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
13.6
13.7
24
24
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
16.0
12.4
20
16
A04AA02
ATC
granisetron; systemic, transdermal
11.2
12.4
24
29
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
5.6
12.3
50
177
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
13.0
11.9
21
21
D13.2
ICD-10 Finland
Benign neoplasm: Duodenum
+∞
11.7
11
*
8140/3-C17.1
ICD-O-3
Adenocarcinoma, NOS, of jejunum
+∞
11.7
11
*
133
Kela drug reimbursment
Severe chronic pancreatic insufficiency
30.0
11.6
15
6
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
14.9
11.0
18
15
JAH00
NOMESCO Finland
Laparotomy
22.5
10.7
15
8
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
13.8
9.0
15
13
JN3BD
NOMESCO Finland
Extensive abdominal CT
5.9
8.3
24
53
UJF92
NOMESCO Finland
Capsular endoscopy
37.4
8.3
10
*
TPX10
NOMESCO Finland
Implantation of vascular injection port
13.7
7.9
13
11
N02AA05
ATC
oxycodone; systemic
4.6
7.8
30
91
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
6.6
7.7
20
38
JN4AD
NOMESCO Finland
Body CT examination
6.6
7.7
20
38
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
87.6
7.5
8
*
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
8.3
7.4
16
23
JN3AD
NOMESCO Finland
Abdominal CT examination
5.8
7.3
21
46
Z51.5
ICD-10 Finland
Palliative care
6.5
7.0
18
34
C17.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of small intestine
43.8
6.9
8
*
K56.5
ICD-10 Finland
Intestinal adhesions [bands] with obstruction
24.9
6.8
9
*
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
13.8
6.8
11
9
D64.9
ICD-10 Finland
Anaemia, unspecified
5.1
6.8
22
55
TPH07
NOMESCO Finland
Cathetrisation of artery
5.3
6.8
21
50
A04AA01
ATC
ondansetron; systemic, rectal
6.4
6.6
17
32

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_SMALL_INTESTINE_ADENO – Adenocarcinoma of small intestine

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).