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Adenocarcinoma of small intestine

EFO Endpoint Browser PheWeb

C3_SMALL_INTESTINE_ADENO

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cancer registry: Topography ICD-O-3 — C17
  • Cancer registry: Morphology ICD-O-3 — 8140|8144|8145
  • Cancer registry: Behaviour codes — 3

1 out of 7 registries used, show all original rules.

96

4. Check minimum number of events

None

96

5. Include endpoints

None

96

6. Filter based on genotype QC (FinnGen only)

93

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

First used in FinnGen datafreeze
DF8

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 93 40 53
Unadjusted period prevalence (%) 0.02 0.01 0.02
Median age at first event (years) 67.91 65.40 69.81

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
96
Matched controls
960
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
130
Kela drug reimbursment
Malignant tumour
+∞
85.7
69
*
L01BC06
ATC
capecitabine; oral
+∞
58.4
50
*
A03FA01
ATC
metoclopramide; systemic, rectal
24.0
58.3
61
65
8140/3-C17.0
ICD-O-3
Adenocarcinoma, NOS, of duodenum
+∞
43.0
38
*
C17.0
ICD-10 Finland
Malignant neoplasm: Duodenum
+∞
43.0
38
*
JFB00
NOMESCO Finland
Partial resection of small intestine
336.7
42.6
40
*
H02AB02
ATC
dexamethasone; systemic
140.3
40.7
41
5
A04AA02
ATC
granisetron; systemic, transdermal
+∞
35.7
32
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
73.7
33.6
37
8
JLC30
NOMESCO Finland
Pancreatoduodenectomy
+∞
29.7
27
*
C17.1
ICD-10 Finland
Malignant neoplasm: Jejunum
+∞
29.7
27
*
8140/3-C17.9
ICD-O-3
Adenocarcinoma, NOS, of small intestine, NOS
+∞
29.7
27
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
29.7
27
*
D37.2
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Small intestine
+∞
28.6
26
*
C17.9
ICD-10 Finland
Malignant neoplasm: Small intestine, unspecified
+∞
28.6
26
*
JN3AD
NOMESCO Finland
Abdominal CT examination
11.7
28.0
36
47
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
29.8
26.0
35
18
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
52.7
23.2
27
7
JN4AD
NOMESCO Finland
Body CT examination
26.0
22.9
32
18
JN4BD
NOMESCO Finland
Extensive body CT
23.4
21.5
31
19
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
7.2
20.9
61
188
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
27.6
20.6
28
14
C17.2
ICD-10 Finland
Malignant neoplasm: Ileum
+∞
20.5
19
*
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
20.5
19
*
B01AB10
ATC
tinzaparin; parenteral
10.4
20.2
26
33
TPH07
NOMESCO Finland
Cathetrisation of artery
8.6
18.8
29
46
N02AA05
ATC
oxycodone; systemic
7.0
18.5
38
82
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
77.9
17.5
19
*
8140/3-C17.2
ICD-O-3
Adenocarcinoma, NOS, of ileum
+∞
17.2
16
*
TPX10
NOMESCO Finland
Implantation of vascular injection port
49.8
17.1
20
5
Z51.5
ICD-10 Finland
Palliative care
24.1
17.1
24
13
WX402
NOMESCO Finland
General anaesthesia
6.7
16.2
33
70
A04AA01
ATC
ondansetron; systemic, rectal
22.8
16.1
23
13
133
Kela drug reimbursment
Severe chronic pancreatic insufficiency
38.9
15.5
19
6
A09AA02
ATC
multienzymes (lipase, protease etc.); oral
27.6
15.0
20
9
WX408
NOMESCO Finland
General anesthesy, balanced
5.5
14.7
41
115
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
63.2
14.3
16
*
JAH00
NOMESCO Finland
Laparotomy
22.5
14.1
20
11
D64.9
ICD-10 Finland
Anaemia, unspecified
7.0
13.9
25
46
8140/3-C17.1
ICD-O-3
Adenocarcinoma, NOS, of jejunum
+∞
13.9
13
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
13.9
13
*
JAH01
NOMESCO Finland
Laparoscopy
23.3
13.6
19
10
WZC00
NOMESCO Finland
Treatment plan or consultation
4.8
13.1
45
148
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
11.9
13.0
24
26
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
+∞
12.8
12
*
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
148.6
12.8
13
*
JN3BD
NOMESCO Finland
Extensive abdominal CT
6.1
11.7
24
50
A04AA55
ATC
palonosetron, combinations; systemic
+∞
11.7
11
*
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
+∞
11.7
11
*
WZC30
NOMESCO Finland
Teaching
5.3
11.4
28
69
UJF32
NOMESCO Finland
Coloscopy
4.4
11.2
41
139
ZXD05
NOMESCO Finland
Urgent procedure
4.2
10.8
47
180
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
122.9
10.6
11
*
C17.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of small intestine
+∞
10.6
10
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.6
10.3
32
95
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.4
10.3
24
56
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
4.0
10.2
50
206
TPH04
NOMESCO Finland
Cathetrisation of vein
4.4
10.0
33
102
ZX120
NOMESCO Finland
Intravenous
9.4
9.8
20
26
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
110.5
9.6
10
*
ZXE20
NOMESCO Finland
More than three and less than five hours
4.8
9.6
26
69
XX3DW
NOMESCO Finland
Time consuming IT work
10.1
8.8
17
20
D13.2
ICD-10 Finland
Benign neoplasm: Duodenum
30.7
8.7
11
*
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
30.7
8.7
11
*
B01AB05
ATC
enoxaparin; parenteral
3.6
8.6
46
197
WF049
NOMESCO Finland
Radiotherapy of metastasis
98.3
8.6
9
*
Z80.0
ICD-10 Finland
Family history of malignant neoplasm of digestive organs
98.3
8.6
9
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
8.4
8
*
A79
ICPC
Malignancy NOS
+∞
8.4
8
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
+∞
8.4
8
*
D37.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other digestive organs
24.5
8.2
11
5
Z31.5
ICD-10 Finland
Genetic counselling
14.8
8.2
13
10
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
49.1
7.9
9
*
K56.5
ICD-10 Finland
Intestinal adhesions [bands] with obstruction
20.4
7.8
11
6
UJF92
NOMESCO Finland
Capsular endoscopy
20.4
7.8
11
6
A02BC02
ATC
pantoprazole; systemic
4.1
7.7
77
476
R11
ICD-10 Finland
Nausea and vomiting
4.9
7.7
19
46
TJD00
NOMESCO Finland
Insertion of nasogastric or naso-gastroduodenal tube
86.5
7.5
8
*
K56.7
ICD-10 Finland
Ileus, unspecified
17.5
7.4
11
7
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
+∞
7.4
7
*
WB123
NOMESCO Finland
Demanding adjuvant cytostatic therapy
+∞
7.4
7
*
C78.6
ICD-10 Finland
Secondary malignant neoplasm of retroperitoneum and peritoneum
+∞
7.4
7
*
WB121
NOMESCO Finland
Demanding neoadjuvant cytostatic therapy
+∞
7.4
7
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.8
7.2
27
90
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
13.6
6.8
11
9
ZXE30
NOMESCO Finland
More than five and less than seven hours
11.2
6.8
12
12
WX600
NOMESCO Finland
Single shot through catheter
74.6
6.5
7
*
WF002
NOMESCO Finland
Radical radiotherapy
74.6
6.5
7
*
R4190
NOMESCO Finland
Nutritional therapy
12.2
6.5
11
10
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.0
6.5
56
306
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
19.6
6.4
9
5
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
6.3
6
*
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
+∞
6.3
6
*
JDE00
NOMESCO Finland
Gastrojejunostomy
+∞
6.3
6
*
C17
ICD-10 Finland
Malignant neoplasm of small intestine
+∞
6.3
6
*
L03AA02
ATC
filgrastim; parenteral
+∞
6.3
6
*
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
+∞
6.3
6
*
A04AD12
ATC
aprepitant; systemic
+∞
6.3
6
*
C25.9
ICD-10 Finland
Malignant neoplasm: Pancreas, unspecified
+∞
6.3
6
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
9.6
6.3
12
14
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
13.8
6.2
10
8
ZXE00
NOMESCO Finland
One hour or less
2.9
6.2
47
237
ZXE10
NOMESCO Finland
More than one and less than three hours
2.9
6.2
44
215
R4110
NOMESCO Finland
Physiotherapy
3.1
6.0
35
152

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
31
25
17.84
33.17
1.6
1.2
—
—
—
0
0
36
78
6.78
17.37
13.8
4.1
103.42
103.87
mmol/l
0.16
36
78
71
292
6.50
16.54
14.0
3.0
32.33
35.85
g/l
5.14
71
274
42
111
5.95
16.32
1.6
1.2
—
—
—
0
0
55
187
5.55
15.90
6.6
3.6
—
—
—
0
0
54
193
5.11
14.38
4.4
1.9
—
—
—
0
0
37
98
5.52
14.09
6.6
2.0
0.78
0.82
mmol/l
1.19
37
86
52
206
4.33
11.55
3.1
1.6
—
—
—
0
0
29
76
5.03
10.92
1.6
1.3
—
—
—
0
0
27
70
4.98
10.25
5.3
2.0
35.37
33.12
u/l
0.09
27
56
23
53
5.39
9.97
1.4
1.1
—
—
—
0
0
67
355
3.94
9.11
10.3
4.1
1.18
1.22
mmol/l
2.73
61
303
72
407
4.08
8.73
20.9
5.3
3.57
4.29
e9/l
2.21
67
353
17
22
9.14
8.31
12.7
7.0
—
—
—
0
0
67
374
3.62
8.00
16.2
15.5
1.20
1.37
inr
1.01
19
113
18
46
4.59
6.80
11.0
6.0
—
—
—
0
0
28
101
3.50
6.60
3.5
1.6
—
—
—
0
0
37
164
3.04
6.17
15.5
4.6
—
—
—
0
0
44
220
2.85
5.84
5.8
2.6
7.42
7.40
ph
—
10
34
40
198
2.75
5.33
3.9
2.8
—
—
—
0
0
44
229
2.70
5.31
3.9
3.0
17.26
339.94
e6/l
0.59
36
175
34
155
2.85
5.28
1.6
1.2
—
—
—
0
0
41
208
2.70
5.18
3.9
3.0
0.41
0.35
e6/l
0.12
34
151
53
323
2.43
4.37
6.2
5.2
—
—
—
0
0
26
114
2.76
4.26
1.9
1.5
29.21
29.36
s
0.07
26
107
10
17
6.43
4.25
6.2
1.8
61.00
16.73
u/ml
—
10
17
46
269
2.36
4.10
4.4
3.6
1222.68
93.32
e6/l
0.46
36
190
19
72
3.04
4.02
5.1
3.0
—
—
—
0
0
7
8
9.32
3.84
3.9
5.6
11.80
11.70
mg/l
—
7
8
10
20
5.45
3.80
1.3
1.6
—
—
—
0
0
39
219
2.32
3.75
3.7
2.7
—
—
—
0
0
54
351
2.23
3.62
5.3
4.7
0.59
0.61
e9/l
0.22
46
310
54
353
2.21
3.55
5.3
4.7
0.03
0.04
e9/l
1.17
46
310
15
53
3.17
3.54
1.3
1.3
—
—
—
0
0
55
366
2.18
3.41
5.4
4.8
0.18
0.20
e9/l
0.40
47
322
54
358
2.16
3.37
5.3
4.8
1.59
1.82
e9/l
1.26
48
320
50
326
2.11
3.21
2.6
2.0
89.22
97.11
pmol/l
0.57
31
163
30
161
2.26
3.13
1.9
1.9
1458.25
1241.42
nmol/l
0.39
24
121
25
125
2.35
3.06
3.2
2.9
1.47
2.36
e6/l
0.35
12
64
5
5
10.44
3.01
3.0
1.8
—
—
—
0
0
12
39
3.37
2.90
1.2
1.2
—
—
—
0
0
10
29
3.73
2.78
1.3
1.4
—
—
—
0
0
5
6
8.70
2.78
1.4
1.2
27.20
30.17
umol/l
—
5
6
47
313
1.98
2.73
24.3
7.7
0.01
0.00
e9/l
0.47
38
253
20
95
2.40
2.73
1.4
1.6
—
—
—
0
0
5
7
7.45
2.58
3.0
1.6
—
—
—
0
0
8
22
3.87
2.42
5.4
1.7
—
—
—
0
0
5
8
6.52
2.40
1.2
1.5
12.91
12.85
ug/l
—
5
8
5
8
6.52
2.40
1.0
1.5
78.20
63.30
pmol/l
—
5
8
12
47
2.78
2.37
1.3
1.5
—
—
—
0
0
27
154
2.05
2.36
4.4
3.2
124.73
141.00
ng/l
0.05
22
123
17
80
2.37
2.36
1.4
1.6
—
—
—
0
0
12
49
2.66
2.20
9.6
3.1
—
—
—
0
0
61
728
0.56
1.93
3.7
4.4
1.24
1.31
mmol/l
0.33
52
663
65
759
0.56
1.82
3.8
4.9
4.31
4.56
mmol/l
1.00
58
703
7
25
2.94
1.68
3.4
2.4
—
—
—
0
0
67
771
0.57
1.66
4.1
5.5
2.60
2.67
mmol/l
0.24
57
711
65
752
0.58
1.61
3.8
4.8
1.26
1.46
mmol/l
3.23
56
691
61
500
1.60
1.38
7.2
4.0
—
—
—
0
0
47
364
1.57
1.35
8.8
5.0
0.00
0.00
estimate
-0.00
13
59
8
34
2.47
1.33
8.5
3.3
—
—
—
0
0
18
274
0.58
1.27
3.2
3.3
—
—
—
0
0
47
370
1.53
1.22
6.1
3.6
0.00
0.06
estimate
0.49
12
54
11
58
2.01
1.17
3.3
2.8
—
—
—
0
0
46
363
1.51
1.17
6.4
3.6
0.00
0.02
estimate
0.49
14
65
10
55
1.91
0.96
5.2
3.1
—
—
—
0
0
9
52
1.81
0.95
1.3
1.3
—
—
—
0
0
6
27
2.30
0.95
2.7
1.9
—
—
—
0
0
26
190
1.51
0.92
5.7
3.8
0.00
0.00
estimate
-0.00
13
58
64
556
1.45
0.92
5.7
3.9
—
—
—
0
0
8
45
1.85
0.87
9.2
3.3
—
—
—
0
0
62
690
0.71
0.78
4.8
4.6
1.87
1.95
mu/l
0.16
56
625
27
207
1.42
0.75
1.8
2.3
328.00
17756.52
umol/l
2.26
22
177
19
137
1.48
0.72
1.4
1.3
2.55
3.02
g/l
—
10
77
7
41
1.76
0.71
5.0
2.1
0.56
0.60
%
—
7
41
7
42
1.72
0.70
5.0
2.1
0.87
1.23
%
—
7
42
5
28
1.83
0.67
1.0
1.3
—
—
—
0
0
11
71
1.62
0.65
1.4
1.5
—
—
—
0
0
23
176
1.40
0.64
2.2
1.9
381.06
424.70
pmol/l
0.46
17
137
8
54
1.52
0.59
3.0
2.4
—
—
—
0
0
39
333
1.29
0.53
4.4
3.7
19.33
54.88
ng/l
2.24
28
248
22
174
1.34
0.51
5.0
3.4
—
—
—
0
0
62
565
1.27
0.49
4.2
3.9
22.52
11.96
mm/h
2.98
56
513
10
69
1.50
0.46
2.7
2.7
—
—
—
0
0
7
50
1.43
0.46
2.9
1.2
—
—
—
0
0
8
55
1.50
0.44
1.3
1.2
—
—
—
0
0
24
197
1.29
0.43
7.1
3.4
—
—
—
0
0
78
815
0.77
0.37
68.1
17.6
36.71
40.41
%
8.91
71
768
72
753
0.82
0.29
4.5
4.8
6.29
6.10
mmol/l
0.38
66
684
5
39
1.30
0.23
1.0
1.2
—
89.82
—
0
13
0
10
0.00
0.21
0.0
3.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
6
47
1.29
0.21
2.0
3.6
4.90
5.00
kpa
—
6
42
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
96.67
—
0
6
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
30
329
0.87
0.20
4.7
3.9
1.81
1.95
ug/l
0.15
23
293
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
10
82
1.25
0.18
1.8
2.5
5.75
6.47
ug/l
—
10
72
20
180
1.14
0.14
2.3
2.6
0.87
0.82
ug/l
0.12
11
120
77
786
0.90
0.10
54.9
14.3
77.97
80.68
umol/l
0.23
77
786
5
62
0.80
0.08
1.6
1.5
—
—
—
0
0
28
268
1.06
0.05
3.9
3.8
18.06
5.46
mg/mmol
0.53
19
163
57
561
1.04
0.02
4.0
3.8
14.57
14.93
pmol/l
0.56
50
498
25
243
1.04
0.01
4.8
4.1
—
—
—
0
0
25
253
0.98
0.00
3.7
3.1
2407.08
292.74
mg/l
0.43
18
161
25
255
0.97
0.00
3.2
3.0
8.05
7.51
mmol/l
0.20
20
210
77
766
1.03
0.00
45.3
11.3
—
—
—
0
0
5
56
0.89
-0.00
1.6
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
80.40
—
0
5
0
6
0.00
-0.00
0.0
1.3
—
175.47
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.3
—
14.67
—
0
6
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
9.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: C3_SMALL_INTESTINE_ADENO – Adenocarcinoma of small intestine

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).