Benign neoplasm: Connective and other soft tissue of abdomen

CD2_BENIGN_CONNSOFT_ABD

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D21.4&
  • Hospital discharge: ICD-9 2155
  • Cause of death: ICD-10 D21.4&
  • Cause of death: ICD-9 2155

2 out of 7 registries used, show all original rules.

101

4. Check minimum number of events

None

101

5. Include endpoints

None

101

6. Filter based on genotype QC (FinnGen only)

101

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D21
Name in latin
Neoplasma benignum textus connectivi abdominis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 814 549 263
Only index persons 728 504 224
Unadjusted period prevalence (%)
Whole population 0.01 0.02 0.01
Only index persons 0.02 0.02 0.01
Median age at first event (years)
Whole population 46.06 43.94 50.31
Only index persons 44.26 42.22 48.84

-FinnGen-

Key figures

All Female Male
Number of individuals 101 71 30
Unadjusted period prevalence (%) 0.02 0.02 0.01
Median age at first event (years) 46.45 41.21 58.86

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
95
Matched controls
951
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D21.4
ICD-10 Finland
Benign neoplasm: Connective and other soft tissue of abdomen
+∞
94.0
74
*
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
12.1
13.5
25
27
JAA10
NOMESCO Finland
Excision of lesion of abdominal wall
+∞
8.5
8
*
9736
FHL
Subcutaneous tumor removal in operating room or anesthesia
24.6
8.2
11
5
2155X
ICD-9 Finland
Other benign neoplasm of connective and other soft tissue, Abdomen[ABDOMENIN BENIGNI PEHMYTKUDOSKASVAIN,TARK MÄÄRITTEL]
+∞
7.4
7
*
6141
FHL
Exploration or removal of a local change in the abdominal wall (umbilical cord, tumor, hematoma, endometrioma)
+∞
6.3
6
*
2155A
ICD-9 Finland
Other benign neoplasm of connective and other soft tissue, Abdomen[ABDOMENIN BENIGNI PEHMYTKUDOSKASVAIN,SIDEKUDOSPERÄI]
+∞
6.3
6
*
D48.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Connective and other soft tissue
16.4
6.0
9
6

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
32
145
2.77
4.95
3.9
3.1
91.7
73.6
ng/l
0.12
18
107
81
623
2.52
3.45
3.7
4.3
14.1
11.3
mm/h
0.84
73
571
41
248
2.10
3.15
2.9
4.0
7.4
7.4
ph
—
7
50
17
70
2.72
3.07
2.2
3.5
—
—
—
0
0
15
59
2.81
2.94
9.8
7.1
—
—
—
0
0
96
844
3.77
2.90
20.2
13.2
23.8
20.9
mg/l
0.35
84
660
20
94
2.41
2.78
1.2
1.3
—
—
—
0
0
42
276
1.89
2.44
3.2
2.0
—
—
—
0
0
32
197
1.91
2.23
6.4
3.9
—
—
—
0
0
21
111
2.13
2.21
3.2
1.7
—
—
—
0
0
13
58
2.42
2.00
1.5
1.7
—
—
—
0
0
73
596
1.81
1.89
4.1
4.3
—
—
—
0
0
96
879
2.86
1.79
23.6
15.4
74.4
73.9
umol/l
0.08
96
879
36
245
1.73
1.77
3.4
3.0
31.7
293.4
e6/l
0.50
26
188
49
366
1.66
1.70
6.9
5.6
1.2
1.2
mmol/l
0.09
43
334
55
424
1.65
1.68
4.1
3.7
0.0
0.0
estimate
—
8
82
47
349
1.65
1.65
2.3
2.0
—
—
—
0
0
32
217
1.69
1.58
3.6
2.9
0.5
0.4
e6/l
0.19
23
158
54
419
1.62
1.57
6.0
4.9
0.0
0.0
estimate
—
8
85
34
235
1.67
1.56
3.0
3.8
13.7
8.9
mg/mmol
0.15
25
151
44
327
1.61
1.51
3.8
3.2
—
—
—
0
0
29
194
1.69
1.49
3.4
3.3
—
—
—
0
0
69
575
1.63
1.45
3.7
3.7
—
—
—
0
0
61
496
1.58
1.40
9.0
9.1
4.3
4.2
e9/l
0.05
53
439
28
189
1.67
1.39
3.8
3.5
1.0
1.0
kg/l
—
5
25
10
47
2.25
1.39
1.3
1.3
—
—
—
0
0
16
91
1.90
1.39
1.5
1.4
—
—
—
0
0
31
217
1.62
1.34
3.5
2.8
—
—
—
0
0
6
24
2.59
1.32
1.3
1.2
—
—
—
0
0
39
290
1.56
1.30
4.1
3.5
185.3
59.1
e6/l
0.63
27
203
23
150
1.69
1.29
1.2
1.3
1.0
8.8
u/ml
—
6
63
6
25
2.49
1.26
1.0
1.3
—
—
—
0
0
29
204
1.59
1.22
1.9
2.6
355.3
6268.3
umol/l
1.06
23
173
23
155
1.63
1.14
1.1
1.3
10.8
30.3
iu/ml
—
6
59
52
421
1.48
1.14
4.2
3.6
0.0
0.0
estimate
—
9
85
41
319
1.48
1.08
4.5
8.3
1.2
1.1
inr
—
10
101
7
33
2.20
1.08
7.3
6.8
22.1
26.3
mmol/l
—
7
33
89
814
1.79
1.06
4.5
4.4
4.5
4.7
mmol/l
0.82
83
754
85
769
1.66
1.05
4.2
3.9
1.3
1.3
mmol/l
0.21
80
699
90
827
1.81
1.04
5.0
4.8
2.6
2.8
mmol/l
0.87
84
761
19
125
1.64
1.03
1.3
1.2
—
—
—
0
0
85
771
1.65
1.01
6.2
5.4
40.3
39.4
mmol/mol
0.35
76
723
0
29
0.00
0.99
0.0
3.6
—
0.1
—
0
8
44
352
1.44
0.99
8.7
9.2
0.0
0.0
e9/l
0.50
36
284
53
439
1.44
0.99
6.1
5.7
0.2
0.2
e9/l
0.03
46
393
88
807
1.70
0.98
4.4
4.3
1.5
1.5
mmol/l
0.47
83
742
29
214
1.50
0.98
6.5
7.2
—
—
—
0
0
30
223
1.49
0.98
2.7
3.1
80.7
68.7
mg/l
0.06
22
147
16
103
1.66
0.94
1.4
1.3
—
—
—
0
0
6
28
2.21
0.93
1.8
1.5
—
—
—
0
0
93
874
1.81
0.91
17.4
12.6
—
—
—
0
0
51
424
1.41
0.91
5.9
5.5
0.0
0.0
e9/l
0.07
44
373
87
800
1.63
0.90
4.5
4.5
5.9
5.9
mmol/l
0.04
80
739
35
275
1.42
0.85
5.3
5.1
—
—
—
0
0
52
438
1.39
0.84
5.8
5.5
2.1
2.0
e9/l
0.09
46
392
82
749
1.50
0.82
25.0
14.4
36.5
39.7
%
1.88
57
560
21
151
1.49
0.79
1.8
1.6
—
—
—
0
0
9
53
1.77
0.78
1.6
1.5
1.3
1.3
g/l
—
9
47
30
233
1.41
0.77
3.7
3.8
0.0
0.0
estimate
—
7
82
23
170
1.46
0.76
1.9
1.9
—
—
—
0
0
50
424
1.35
0.75
6.0
5.5
0.6
0.6
e9/l
0.30
43
371
7
38
1.90
0.75
20.7
7.8
—
—
—
0
0
7
38
1.90
0.75
2.7
2.5
0.6
0.7
%
—
7
38
5
25
2.05
0.74
1.4
1.2
18.3
10.9
u/l
—
5
19
17
119
1.52
0.73
1.3
1.5
176.0
394.1
titre
—
5
27
7
41
1.76
0.71
2.7
2.5
1.0
1.1
%
—
7
41
7
44
1.63
0.66
2.7
3.5
127.7
129.6
g/l
—
7
44
5
29
1.76
0.64
2.2
1.2
—
—
—
0
0
8
52
1.58
0.61
1.8
4.9
—
—
—
0
0
14
98
1.50
0.60
1.8
2.9
9.7
7.6
umol/l
0.20
14
81
19
246
0.72
0.58
1.7
1.5
—
—
—
0
0
9
59
1.58
0.57
4.7
4.4
4.4
4.7
pmol/l
—
9
51
9
59
1.58
0.57
3.6
2.1
5.1
5.0
ug/l
—
9
51
6
39
1.57
0.54
3.5
3.7
25.4
24.9
mmol/l
—
6
39
39
333
1.28
0.52
2.2
2.0
78.4
97.1
pmol/l
0.83
16
169
12
84
1.49
0.52
1.3
2.2
342.4
362.8
nmol/l
0.12
12
78
29
239
1.30
0.50
3.3
2.9
—
—
—
0
0
11
76
1.50
0.50
1.5
1.3
—
—
—
0
0
11
76
1.50
0.50
2.5
2.2
0.2
0.2
g/l
0.24
11
70
8
58
1.41
0.43
1.0
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
24
199
1.27
0.40
1.5
1.2
0.7
0.8
u/ml
—
7
60
9
69
1.33
0.38
4.4
3.1
—
—
—
0
0
9
70
1.31
0.38
2.7
4.0
—
—
—
0
0
32
278
1.22
0.36
2.8
2.5
63.9
54.2
u/l
0.75
27
256
33
288
1.22
0.35
3.9
3.7
2.4
2.4
mmol/l
0.02
33
251
13
103
1.30
0.30
1.5
1.7
—
—
—
0
0
13
104
1.29
0.28
2.2
1.5
—
—
—
0
0
9
75
1.22
0.26
1.3
1.1
—
—
—
0
0
5
37
1.37
0.24
1.2
1.1
—
—
—
0
0
7
95
0.72
0.23
1.7
1.9
—
—
—
0
0
5
42
1.20
0.22
6.0
3.8
—
—
—
0
0
18
207
0.84
0.21
1.8
1.4
18.7
21.6
nmol/l
0.50
18
170
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
2.0
—
612.2
—
0
6
0
10
0.00
0.21
0.0
2.8
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
5.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
2.8
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
5
65
0.76
0.17
2.6
4.3
—
0.6
—
0
13
8
71
1.14
0.16
1.3
1.5
—
—
—
0
0
33
308
1.11
0.13
3.3
4.1
26.5
44.3
ng/l
0.46
20
206
5
45
1.12
0.10
2.8
1.6
—
—
—
0
0
5
47
1.07
0.09
1.6
3.2
—
7.5
—
0
5
6
56
1.08
0.09
1.7
1.4
—
—
—
0
0
6
58
1.04
0.08
2.8
1.9
61.2
67.3
g/l
—
6
52
7
67
1.05
0.08
2.0
2.3
—
—
—
0
0
30
285
1.07
0.07
3.8
2.9
—
—
—
0
0
21
197
1.08
0.07
4.1
4.8
—
—
—
0
0
22
233
0.93
0.06
3.7
3.9
—
—
—
0
0
25
243
1.04
0.01
4.7
3.3
—
—
—
0
0
18
175
1.03
0.00
1.6
1.3
2.5
2.5
g/l
0.01
11
99
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
9
96
0.93
0.00
1.1
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
9.2
—
999.2
—
0
5
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
9
92
0.98
0.00
1.2
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
10.8
—
1610.4
—
0
5
0
6
0.00
0.00
0.0
3.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
5.8
—
0.7
—
0
6
6
66
0.90
0.00
2.5
4.0
—
0.5
—
0
11
0
7
0.00
0.00
0.0
4.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
7
73
0.96
0.00
2.0
4.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
1.7
—
0
5
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_CONNSOFT_ABD and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_CONNSOFT_ABD 1.671 [1.13, 2.47] 0.01
Birth year 0.997 [0.99, 1.01] 0.464

During the follow-up period (1.1.1998 — 31.12.2019), 55 out of 382 females with CD2_BENIGN_CONNSOFT_ABD died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_CONNSOFT_ABD.

N-year risk Females Males
1 0.156% No data
5 1.052% No data
10 2.632% No data
15 4.982% No data
20 8.626% No data

Relationships between endpoints

Index endpoint: CD2_BENIGN_CONNSOFT_ABD – Benign neoplasm: Connective and other soft tissue of abdomen

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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