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Carcinoma in situ of skin of lip

CD2_INSITU_SKIN_LIP_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

-

2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D04.0&
  • Hospital discharge: ICD-9 2320
  • Cause of death: ICD-10 D04.0&
  • Cause of death: ICD-9 2320

2 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

None

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D04
Name in latin
Carcinoma in situ cutis labii (oris)

Case counts by codes

FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 97 38 59
Unadjusted period prevalence (%) 0.02 0.01 0.03
Median age at first event (years) 73.30 73.96 72.88

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
88
Matched controls
881
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D04.0
ICD-10 Finland
Carcinoma in situ: Skin of lip
+∞
126.7
88
*
L57.0
ICD-10 Finland
Actinic keratosis
45.8
45.8
59
37
TQW99
NOMESCO Finland
Other minor procedure on skin
74.7
37.3
41
10
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
31.7
37.1
52
38
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
469.7
33.2
31
*
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
45.3
32.0
39
15
ZXC20
NOMESCO Finland
Use of chemical agents
382.7
28.5
27
*
D04.3
ICD-10 Finland
Carcinoma in situ: Skin of other and unspecified parts of face
127.5
26.4
27
*
QBA25
NOMESCO Finland
Destruction of lesion of skin of trunk
+∞
25.2
23
*
EAA10
NOMESCO Finland
Excision of lesion of lip
90.6
24.4
26
*
C44.51
ICD-10 Finland
Basocellular carcinoma of the skin on the torso
+∞
22.9
21
*
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
51.6
22.3
26
7
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
21.7
20
*
C44.32
ICD-10 Finland
Spinocellular carcinoma of the skin on another or unspecified part of the face
+∞
19.5
18
*
ZQZ00
NOMESCO Finland
Treatment of several skin areas
+∞
19.5
18
*
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
27.7
19.2
26
13
R23.8
ICD-10 Finland
Other and unspecified skin changes
13.1
18.6
35
42
L56.8
ICD-10 Finland
Other specified acute skin changes due to ultraviolet radiation
+∞
18.4
17
*
ZZR00
NOMESCO Finland
Flap of skin
111.6
17.3
18
*
D04.5
ICD-10 Finland
Carcinoma in situ: Skin of trunk
207.5
17.1
17
*
EAA30
NOMESCO Finland
Partial excision of lower lip
+∞
13.9
13
*
C44.02
ICD-10 Finland
Spinocellular carcinoma of the lip skin
+∞
13.9
13
*
D06BB10
ATC
imiquimod; topical
23.7
13.6
19
10
QCE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in upper limb
34.5
13.5
17
6
ZXC10
NOMESCO Finland
Use of laser
35.6
12.1
15
5
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
+∞
11.7
11
*
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
11.3
11.6
22
25
R4110
NOMESCO Finland
Physiotherapy
5.2
11.2
44
142
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
124.1
10.7
11
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
124.1
10.7
11
*
116
Kela drug reimbursment
Prostate cancer
+∞
10.6
10
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
10.6
10
*
L02AE02
ATC
leuprorelin; implant, parenteral
+∞
9.5
9
*
C44.21
ICD-10 Finland
Basocellular carcinoma of the skin of the outer ear and the outer ear canal
+∞
9.5
9
*
C44.61
ICD-10 Finland
Basocellular carcinoma of the skin of the upper extremity including the shoulder
+∞
9.5
9
*
XF400
NOMESCO Finland
ECG with 12 standard connections
4.6
8.7
35
111
D04.6
ICD-10 Finland
Carcinoma in situ: Skin of upper limb, including shoulder
99.0
8.6
9
*
C44.41
ICD-10 Finland
Basocellular carcinoma of the skin of the scalp and neck
99.0
8.6
9
*
C44.30
ICD-10 Finland
Malignant tumor of the skin on another or unspecified part of the face without histology
+∞
8.5
8
*
WX002
NOMESCO Finland
Sedation and analgesia
4.5
8.4
34
108
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
17.1
8.0
12
8
D04.4
ICD-10 Finland
Carcinoma in situ: Skin of scalp and neck
49.5
7.9
9
*
ZXA05
NOMESCO Finland
Left side
3.9
7.7
41
162
ZXC50
NOMESCO Finland
Cryotherapy
17.7
7.4
11
7
8070/3-C44.9
ICD-O-3
Squamous cell carcinoma, NOS, of skin, NOS
+∞
7.4
7
*
8090/3-C44.5
ICD-O-3
Basal cell carcinoma, NOS, of skin of trunk
+∞
7.4
7
*
PJA12
NOMESCO Finland
Sentinel node biopsy
+∞
7.4
7
*
C44.62
ICD-10 Finland
Spinocellular carcinoma of the skin of the upper extremity including the shoulder
+∞
7.4
7
*
C44.42
ICD-10 Finland
Spinocellular carcinoma of the skin of the scalp and neck
+∞
7.4
7
*
D07AB08
ATC
desonide; topical
5.4
7.0
21
48
J01DB01
ATC
cefalexin; oral
4.4
6.5
77
540
S18
ICPC
Laceration/cut
3.2
6.3
50
258
Y77
ICPC
Malignant neoplasm prostate
+∞
6.3
6
*
DAB10
NOMESCO Finland
Partial excision of auricle
+∞
6.3
6
*
YL1BD
NOMESCO Finland
Extensive CT examination of pelvis for dose design of radiotherapy
+∞
6.3
6
*
130
Kela drug reimbursment
Malignant tumour
+∞
6.3
6
*
8070/3-C44.2
ICD-O-3
Squamous cell carcinoma, NOS, of external ear
+∞
6.3
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
40
53
12.14
31.00
2.6
1.1
—
—
—
0
0
70
192
10.51
28.89
5.2
1.6
—
—
—
0
0
22
18
15.51
22.88
1.2
1.2
—
—
—
0
0
18
24
8.98
13.17
1.3
1.2
—
—
—
0
0
24
56
5.37
10.27
7.0
8.8
—
—
—
0
0
55
269
3.41
8.18
5.1
3.6
51.8
94.4
e6/l
0.56
40
191
45
196
3.42
8.06
4.7
2.9
—
—
—
0
0
47
214
3.32
7.77
4.6
2.8
0.7
0.4
e6/l
0.30
36
152
50
239
3.25
7.58
4.6
2.9
132.6
334.2
e6/l
0.32
40
181
38
157
3.34
7.29
8.7
4.5
—
—
—
0
0
35
151
3.06
6.10
2.2
3.7
—
—
—
0
0
22
72
3.66
5.95
1.6
1.5
—
—
—
0
0
15
37
4.61
5.87
2.7
2.0
1.8
1.6
g/l
0.36
15
32
80
557
3.49
5.56
39.0
20.3
329.2
331.4
g/l
1.15
80
549
55
318
2.68
5.37
5.4
3.2
34.4
34.5
g/l
0.04
49
288
23
83
3.32
5.33
5.3
3.9
—
—
—
0
0
15
42
4.04
4.99
4.2
7.7
25.0
24.7
mmol/l
0.08
15
35
77
542
3.04
4.89
36.8
18.0
14.2
13.8
%
1.51
77
520
26
107
2.95
4.81
2.4
2.7
0.8
0.8
mmol/l
0.83
26
100
47
274
2.39
4.24
2.4
3.7
—
—
—
0
0
80
596
2.95
4.18
35.4
16.3
39.1
39.6
%
0.32
63
356
28
129
2.65
4.15
3.9
2.4
11.5
11.8
umol/l
0.10
28
116
18
65
3.17
4.12
3.1
2.0
6.4
7.3
umol/l
0.29
18
57
70
492
2.52
4.06
5.1
4.2
—
—
—
0
0
16
56
3.22
3.84
1.5
1.4
—
—
—
0
0
53
340
2.23
3.67
8.5
4.5
0.6
0.6
e9/l
0.14
45
286
41
237
2.26
3.66
7.5
4.9
—
—
—
0
0
18
70
2.93
3.63
7.7
6.9
13.0
11.9
mmol/l
0.24
18
63
12
36
3.66
3.61
7.4
8.4
—
—
—
0
0
53
342
2.21
3.60
8.5
4.5
0.0
0.0
e9/l
0.52
44
292
56
371
2.21
3.54
12.3
5.3
4.7
4.7
e9/l
0.06
50
319
22
97
2.64
3.52
6.1
6.1
1.2
1.5
mmol/l
0.06
16
74
53
345
2.18
3.49
8.8
4.6
1.9
1.8
e9/l
0.11
45
297
47
293
2.17
3.44
11.4
8.0
0.0
0.0
e9/l
0.49
40
233
38
219
2.21
3.37
3.4
2.1
—
—
—
0
0
53
352
2.11
3.24
2.9
2.1
92.4
91.2
pmol/l
0.06
28
181
53
353
2.11
3.20
8.7
4.5
0.1
0.2
e9/l
1.88
45
303
20
88
2.60
3.20
2.3
1.8
—
—
—
0
0
8
16
5.34
3.12
2.1
3.5
—
—
—
0
0
18
77
2.64
3.04
1.2
2.3
73.7
60.8
e9/l
—
7
65
69
515
2.18
3.01
5.2
4.2
—
—
—
0
0
35
206
2.09
2.87
3.1
2.1
3.1
2.8
mg/l
0.29
30
174
8
18
4.74
2.86
1.3
1.1
—
—
—
0
0
21
101
2.38
2.79
1.9
1.6
—
—
—
0
0
7
15
4.94
2.65
2.0
2.1
60.1
70.9
%
—
7
15
36
220
2.01
2.64
6.1
4.3
—
—
—
0
0
11
39
3.05
2.57
1.6
1.5
—
—
—
0
0
11
40
2.97
2.47
1.6
1.3
—
—
—
0
0
10
36
2.98
2.28
1.3
8.0
26.8
24.6
mmol/l
—
10
36
36
233
1.87
2.17
4.1
3.3
—
—
—
0
0
86
739
2.44
2.12
31.3
18.2
100.7
86.4
umol/l
1.16
86
739
22
356
0.51
2.08
4.4
4.1
25.1
54.6
ng/l
1.79
17
270
8
27
3.13
1.98
1.3
1.2
—
—
—
0
0
32
205
1.84
1.97
3.5
2.4
14656.5
6401.6
umol/l
0.24
26
170
11
46
2.57
1.93
2.3
2.4
—
—
—
0
0
37
250
1.78
1.91
4.5
3.2
109.8
309.1
mg/l
0.35
25
164
10
40
2.67
1.90
2.4
2.2
1.0
1.1
%
—
10
40
25
155
1.83
1.68
1.4
1.2
—
—
—
0
0
85
751
2.07
1.55
31.7
19.0
138.7
139.8
mmol/l
2.80
85
721
85
752
2.05
1.53
32.5
19.1
4.0
4.0
mmol/l
0.95
85
723
7
28
2.61
1.48
1.7
1.9
—
—
—
0
0
10
46
2.31
1.45
1.0
1.3
—
—
—
0
0
81
710
1.85
1.44
25.6
14.9
33.4
24.2
mg/l
1.29
65
563
17
263
0.57
1.27
4.4
4.1
—
—
—
0
0
36
265
1.57
1.27
5.3
4.0
24.4
7.8
mg/mmol
0.48
23
171
6
25
2.49
1.26
1.2
1.4
—
—
—
0
0
85
767
1.87
1.21
39.0
21.6
92.1
91.8
fl
0.28
85
744
85
768
1.86
1.19
39.3
21.8
128.4
134.1
g/l
2.59
85
744
85
768
1.86
1.19
38.9
21.6
30.5
30.5
pg
0.02
85
745
5
20
2.58
1.16
1.0
1.2
—
—
—
0
0
7
33
2.21
1.08
3.3
3.2
4.0
4.3
pmol/l
—
7
28
9
46
2.05
1.07
1.0
1.2
—
—
—
0
0
54
448
1.46
1.03
5.6
4.8
6.9
7.0
mmol/l
0.22
54
416
27
196
1.52
0.99
5.0
2.7
0.6
0.8
ug/l
0.56
19
139
7
37
1.96
0.96
4.0
4.1
—
—
—
0
0
8
42
1.98
0.91
3.4
2.2
8.1
11.1
g/l
—
8
34
5
23
2.24
0.77
4.0
2.9
—
—
—
0
0
10
60
1.74
0.75
6.2
4.2
—
—
—
0
0
17
119
1.52
0.73
1.6
1.3
2.5
2.9
g/l
—
5
59
5
28
1.83
0.67
1.0
1.2
—
—
—
0
0
15
207
0.67
0.66
5.4
3.6
—
—
—
0
0
14
193
0.68
0.61
1.4
1.8
459.6
437.8
pmol/l
—
9
158
8
52
1.59
0.61
1.3
1.5
—
—
—
0
0
0
22
0.00
0.60
0.0
1.1
—
—
—
0
0
9
60
1.55
0.56
1.1
1.2
—
—
—
0
0
9
63
1.47
0.54
1.1
1.6
471.1
379.5
nmol/l
—
9
57
13
93
1.46
0.51
1.5
1.3
—
—
—
0
0
78
730
1.35
0.50
19.1
14.2
—
—
—
0
0
5
32
1.59
0.43
1.8
1.8
22.8
25.5
mmol/l
—
5
24
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
0.2
—
0
16
0
17
0.00
0.41
0.0
1.2
—
1.1
—
0
17
9
67
1.38
0.39
1.1
1.3
—
—
—
0
0
6
44
1.39
0.35
2.5
2.5
0.0
0.2
e6/l
—
6
44
7
53
1.35
0.31
2.1
2.4
—
—
—
0
0
16
186
0.83
0.21
3.7
3.7
—
—
—
0
0
0
10
0.00
0.21
0.0
3.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
5
65
0.76
0.17
4.4
2.7
—
—
—
0
0
11
124
0.87
0.09
7.4
3.8
—
—
—
0
0
5
60
0.82
0.08
4.0
3.9
4.9
5.2
kpa
—
5
54
0
9
0.00
0.00
0.0
1.3
—
6.0
—
0
9
0
9
0.00
0.00
0.0
1.6
—
32.8
—
0
9
5
54
0.92
0.00
1.8
1.5
—
—
—
0
0
0
9
0.00
0.00
0.0
3.0
—
66.7
—
0
9
0
9
0.00
0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
2490.0
—
0
5
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
5
57
0.87
0.00
4.0
4.1
—
7.4
—
0
5
0
5
0.00
0.00
0.0
5.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
4.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
10
100
1.00
0.00
3.1
2.6
12.1
9.5
ug/l
—
10
86
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
250.8
—
0
5
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
329.8
—
0
5
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
5
59
0.84
0.00
2.4
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
4.7
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_INSITU_SKIN_LIP_EXALLC – Carcinoma in situ of skin of lip

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).