Other leukaemias of specified cell type

CD2_OTHER_LEUKAEMIA_SPECIFIED_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

-

2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C94
  • Hospital discharge: ICD-9 207[0-8]
  • Hospital discharge: ICD-8 207[0-2]
  • Cause of death: ICD-10 C94
  • Cause of death: ICD-9 207[0-8]
  • Cause of death: ICD-8 207[0-2]

2 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

None

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF8
Parent code in ICD-10
C81-C96
Name in latin
Aliae leuc(h)aemiae typo cellulari specificato

Case counts by codes

FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 89 48 41
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 54.77 52.22 57.76

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
80
Matched controls
801
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
213.2
37.4
36
*
127
Kela drug reimbursment
Transplant complication
104.4
30.7
32
5
C94.0
ICD-10 Finland
Acute erythroid leukaemia
+∞
25.4
23
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
35.0
21.9
28
12
XW000
NOMESCO Finland
Bone marrow biopsy
39.8
21.8
27
10
C94.7
ICD-10 Finland
Other specified leukaemias
+∞
19.6
18
*
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
20.9
19.2
29
21
L04AA06
ATC
mycophenolic acid; systemic
55.9
18.3
21
5
L04AD01
ATC
ciclosporin; systemic
55.9
18.3
21
5
ZX120
NOMESCO Finland
Intravenous
14.2
15.9
28
29
L04AA01
ATC
[U] ciclosporin; systemic
34.9
15.1
19
7
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
65.6
14.4
16
*
C92.0
ICD-10 Finland
Acute myeloblastic leukaemia [AML]
+∞
13.9
13
*
L03AA02
ATC
filgrastim; parenteral
167.2
13.9
14
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
9.9
13.2
28
41
WW500
NOMESCO Finland
Blood transfusion
20.3
12.9
19
12
GD1AA
NOMESCO Finland
Thorax X-ray examination
6.0
12.9
54
205
H02AB02
ATC
dexamethasone; systemic
153.0
12.8
13
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
76.5
12.0
13
*
C91.0
ICD-10 Finland
Acute lymphoblastic leukaemia [ALL]
+∞
11.7
11
*
Z94.0
ICD-10 Finland
Kidney transplant status
41.7
11.7
14
*
H02AB09
ATC
hydrocortisone; systemic
41.7
11.7
14
*
R50.9
ICD-10 Finland
Fever, unspecified
8.3
11.5
27
46
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
10.3
11.4
23
30
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
51.0
11.3
13
*
R4110
NOMESCO Finland
Physiotherapy
5.7
10.9
38
110
Z94.8
ICD-10 Finland
Other transplanted organ and tissue status
+∞
10.6
10
*
TK800
NOMESCO Finland
Hemodialysis
23.8
10.2
14
7
Z49.1
ICD-10 Finland
Extracorporeal dialysis
62.9
9.9
11
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
34.8
9.7
12
*
ZX108
NOMESCO Finland
Inhalation
112.8
9.6
10
*
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
+∞
9.6
9
*
C03CA01
ATC
furosemide; systemic
5.0
9.5
37
118
J01MA12
ATC
levofloxacin; systemic
6.1
9.4
28
65
H02AB04
ATC
methylprednisolone; systemic
6.0
9.1
27
62
A05AA02
ATC
ursodeoxycholic acid; oral
56.4
8.9
10
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
5.8
8.9
27
64
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
16.9
8.5
13
9
C94.4
ICD-10 Finland
Acute panmyelosis with myelofibrosis
+∞
8.5
8
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
8.5
8
*
ZZR00
NOMESCO Finland
Flap of skin
+∞
8.5
8
*
9835/3-C42.1
ICD-O-3
Precursor cell lymphoblastic leukemia, NOS, of bone marrow
+∞
8.5
8
*
C94.2
ICD-10 Finland
Acute megakaryoblastic leukaemia
+∞
8.5
8
*
TAB00
NOMESCO Finland
Lumbar puncture
13.8
8.5
14
12
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
37.6
8.3
10
*
A11CC03
ATC
alfacalcidol; systemic
37.6
8.3
10
*
TGC00
NOMESCO Finland
Bronchial lavation
17.3
8.0
12
8
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
50.1
7.9
9
*
KA1AE
NOMESCO Finland
Kidney ultrasound examination
50.1
7.9
9
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
6.4
7.8
21
42
N18.8
ICD-10 Finland
Other chronic renal failure
28.2
7.8
10
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
8.0
7.6
17
26
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
87.9
7.6
8
*
J05AB01
ATC
aciclovir; systemic
4.6
7.5
29
88
JN4BD
NOMESCO Finland
Extensive body CT
10.3
7.4
14
16
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
7.4
7
*
C94.1
ICD-10 Finland
Chronic erythremia
+∞
7.4
7
*
D47.1
ICD-10 Finland
Chronic myeloproliferative disease
+∞
7.4
7
*
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
11.7
7.4
13
13
A12AA04
ATC
calcium carbonate; oral
33.3
7.3
9
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
4.6
7.1
27
80
B03XA02
ATC
darbepoetin alfa; parenteral
43.9
6.9
8
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
10.1
6.9
13
15
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
10.1
6.9
13
15
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
8.7
6.8
14
19
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
8.7
6.8
14
19
J01MA14
ATC
moxifloxacin; systemic
7.1
6.7
16
27
ZXA00
NOMESCO Finland
Right side
3.9
6.6
33
123
TPH04
NOMESCO Finland
Cathetrisation of vein
4.1
6.6
28
92
6BA02
NOMESCO Finland
NA
75.6
6.5
7
*
Z94.1
ICD-10 Finland
Heart transplant status
75.6
6.5
7
*
B03XA01
ATC
erythropoietin; parenteral
75.6
6.5
7
*
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
12.5
6.5
11
10
J05AB11
ATC
valaciclovir; oral
5.0
6.4
21
53
TPX10
NOMESCO Finland
Implantation of vascular injection port
20.0
6.4
9
5
ZX112
NOMESCO Finland
Subcutaneous
29.2
6.4
8
*
9961/3-C42.1
ICD-O-3
Primary myelofibrosis of bone marrow
+∞
6.3
6
*
C90.0
ICD-10 Finland
Multiple myeloma
+∞
6.3
6
*
NEA10
NOMESCO Finland
Exploration of soft tissue of pelvis, percutaneous
+∞
6.3
6
*
C94.5
ICD-10 Finland
Acute myelofibrosis
+∞
6.3
6
*
WD135
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
6.3
6
*
20700
ICD-8 Finland
Other and unspecified leukaemia, Leukaemia, acute
+∞
6.3
6
*
WX408
NOMESCO Finland
General anesthesy, balanced
3.8
6.3
30
109
L01BB02
ATC
mercaptopurine; oral
16.6
6.1
9
6

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
25
24
14.10
23.79
2.1
1.3
—
—
—
0
0
42
88
8.14
21.62
22.0
5.2
1.1
1.1
mmol/l
0.16
42
82
22
24
11.85
19.04
1.5
1.2
—
—
—
0
0
20
21
11.99
17.69
12.5
5.3
1.8
1.4
mg/l
0.95
20
21
31
58
7.67
17.35
6.0
2.8
71.3
66.6
e9/l
0.33
22
44
40
101
6.38
16.53
11.3
2.4
0.8
0.8
mmol/l
0.90
40
94
34
77
6.53
15.65
8.9
2.7
1.9
1.6
%
1.29
34
70
54
186
5.84
15.57
17.0
3.0
7.4
7.4
ph
—
8
25
20
9
28.12
15.02
1.6
1.0
—
—
—
0
0
49
163
5.46
14.52
12.4
4.2
—
—
—
0
0
68
321
5.74
12.54
25.9
5.7
1.2
1.2
mmol/l
0.37
62
285
30
73
5.69
12.53
2.4
1.4
—
—
—
0
0
17
9
22.93
12.14
1.6
1.0
137.4
—
u/ml
—
7
0
15
5
35.53
12.09
1.4
1.0
—
—
—
0
0
23
46
6.39
11.74
14.7
5.4
1.8
0.3
%
2.01
17
14
15
6
29.63
11.58
2.8
2.0
—
—
—
0
0
56
244
4.49
11.00
18.0
5.3
—
—
—
0
0
22
46
6.02
10.68
1.5
1.3
—
—
—
0
0
14
6
27.25
10.62
1.4
1.0
—
—
—
0
0
14
6
27.25
10.62
3.6
2.5
—
—
—
0
0
21
43
6.08
10.40
14.6
5.6
0.5
0.0
%
1.82
16
12
44
172
4.08
9.80
21.2
4.4
—
—
—
0
0
67
353
4.63
9.70
20.9
5.4
55.2
56.9
%
0.39
67
330
13
6
24.98
9.67
1.7
1.0
—
—
—
0
0
30
93
4.36
9.10
5.5
2.2
2.1
2.4
g/l
1.19
30
87
18
41
5.25
7.84
13.1
5.9
1.3
0.0
%
—
9
10
11
6
20.62
7.82
6.6
5.0
13.2
11.8
mg/l
—
11
6
30
106
3.76
7.44
2.5
1.5
—
—
—
0
0
7
0
+∞
7.39
1.0
0.0
—
—
—
0
0
29
101
3.78
7.33
5.8
2.2
12.1
14.8
umol/l
1.48
29
93
22
64
4.24
7.11
12.2
8.4
—
—
—
0
0
25
80
3.96
7.11
2.5
1.9
—
—
—
0
0
34
135
3.46
7.02
2.4
1.7
—
—
—
0
0
10
7
15.86
6.57
3.1
1.4
—
—
—
0
0
10
7
15.86
6.57
3.1
1.4
—
—
—
0
0
10
7
15.86
6.57
3.1
1.4
—
—
—
0
0
10
7
15.86
6.57
3.1
1.4
—
—
—
0
0
59
338
3.21
6.41
25.3
3.8
11.5
12.4
umol/l
0.27
59
315
17
44
4.54
6.33
13.4
5.4
0.4
0.0
%
0.98
11
11
6
0
+∞
6.32
1.3
0.0
—
—
—
0
0
43
208
3.07
6.27
8.4
2.0
—
—
—
0
0
41
196
3.02
6.06
6.0
1.8
2.3
2.4
mmol/l
1.10
41
158
34
147
3.12
5.98
4.6
2.3
3.6
5.8
e6/l
0.97
34
124
55
313
2.98
5.87
29.1
7.5
0.0
0.0
e9/l
1.12
45
235
26
97
3.37
5.81
3.6
1.9
—
—
—
0
0
41
201
2.93
5.73
5.8
2.9
—
—
—
0
0
42
209
2.91
5.71
5.9
3.0
0.2
0.5
e6/l
1.22
37
149
10
18
6.13
5.45
6.4
4.3
23.4
22.5
mmol/l
—
10
13
48
262
2.81
5.41
26.9
6.7
1.2
1.2
inr
0.07
14
63
43
223
2.80
5.33
6.8
3.0
38.8
61.5
e6/l
0.27
38
163
5
0
+∞
5.25
3.0
0.0
—
—
—
0
0
41
210
2.77
5.17
3.8
3.2
—
—
—
0
0
16
49
3.76
4.73
9.1
9.2
108.8
122.1
g/l
2.01
16
49
7
5
15.01
4.65
9.1
1.4
—
—
—
0
0
8
8
10.83
4.62
19.6
4.9
—
—
—
0
0
30
141
2.70
4.36
16.3
5.5
—
—
—
0
0
12
32
4.18
4.24
10.3
10.9
0.7
0.6
%
0.28
12
32
40
219
2.50
4.24
2.9
1.5
—
—
—
0
0
11
28
4.34
4.11
2.4
1.2
—
—
—
0
0
12
33
4.05
4.08
10.3
10.7
1.4
1.7
%
0.28
12
33
7
8
9.37
3.84
1.1
1.0
—
—
—
0
0
31
157
2.50
3.81
3.8
1.3
2.1
2.5
g/l
0.43
24
78
44
262
2.34
3.77
8.4
3.5
67.5
167.6
e6/l
0.98
38
174
14
46
3.42
3.72
5.6
3.4
—
—
—
0
0
13
44
3.29
3.29
5.9
1.2
—
—
—
0
0
6
8
7.94
3.10
2.5
1.3
—
—
—
0
0
5
5
10.48
3.01
2.6
1.6
—
—
—
0
0
30
168
2.19
2.84
8.6
4.0
0.0
0.0
estimate
—
7
60
7
14
5.33
2.78
8.0
1.0
—
—
—
0
0
7
14
5.33
2.78
4.6
1.8
—
—
—
0
0
6
10
6.34
2.74
4.2
1.1
—
—
—
0
0
32
187
2.11
2.70
2.0
1.4
—
—
—
0
0
51
355
2.02
2.66
6.8
3.4
0.0
0.0
estimate
—
9
55
43
283
2.00
2.62
1.7
1.9
86.2
93.5
pmol/l
0.46
26
140
45
302
1.99
2.58
6.9
2.4
327.9
102.2
ug/l
3.65
45
277
50
351
1.97
2.50
8.6
4.7
0.0
0.0
estimate
—
8
58
11
41
2.92
2.38
8.4
3.4
—
—
—
0
0
18
89
2.28
2.25
3.0
1.4
—
—
—
0
0
5
9
5.81
2.24
1.2
1.0
—
—
—
0
0
29
174
1.99
2.23
5.5
3.1
—
—
—
0
0
7
19
3.90
2.20
14.4
7.1
—
—
—
0
0
42
287
1.88
2.20
4.9
3.0
—
—
—
0
0
6
14
4.51
2.19
6.2
2.9
3.5
5.3
e9/l
—
6
14
6
14
4.51
2.19
7.5
4.1
54.8
60.6
%
—
6
14
14
63
2.45
2.14
1.8
1.0
—
—
—
0
0
7
20
3.71
2.10
8.4
1.1
55.0
4.2
e6/l
—
7
15
7
20
3.71
2.10
8.4
1.2
64.3
470.9
e6/l
—
7
15
48
350
1.81
1.98
7.1
3.4
0.0
0.0
estimate
—
9
60
7
22
3.36
1.92
3.7
3.3
—
—
—
0
0
10
40
2.69
1.91
21.9
2.2
1.2
1.2
mmol/l
—
10
35
34
226
1.82
1.89
6.1
4.0
28.4
6.9
mg/mmol
1.01
27
138
9
35
2.74
1.86
5.9
5.7
—
—
—
0
0
32
214
1.77
1.72
5.7
3.3
1628.6
353.9
mg/l
0.37
27
133
5
15
3.47
1.54
1.8
2.9
82.2
53.7
mmol/l
—
5
15
6
21
2.99
1.53
1.3
1.1
—
—
—
0
0
59
481
1.67
1.45
6.1
3.6
—
—
—
0
0
5
18
2.88
1.30
3.2
1.4
59.4
36.9
nmol/l
—
5
18
5
20
2.59
1.16
1.2
1.2
—
—
—
0
0
5
21
2.46
1.10
1.0
1.2
—
—
—
0
0
11
61
1.92
1.04
1.0
1.2
—
—
—
0
0
0
29
0.00
0.99
0.0
1.1
—
—
—
0
0
9
52
1.81
0.95
8.0
2.7
—
—
—
0
0
6
29
2.14
0.91
2.3
1.1
—
—
—
0
0
16
231
0.63
0.89
2.2
2.9
—
—
—
0
0
58
502
1.45
0.86
8.7
4.0
—
—
—
0
0
10
58
1.82
0.83
11.2
6.0
24.6
25.2
mmol/l
—
10
58
24
180
1.46
0.76
7.7
3.3
—
—
—
0
0
5
24
2.15
0.76
3.2
4.9
1.3
1.7
%
—
5
24
5
25
2.06
0.74
3.4
3.8
0.5
0.1
g/l
—
5
10
5
28
1.83
0.67
1.0
1.1
—
—
—
0
0
9
59
1.58
0.57
1.8
3.5
296.9
310.1
ng/l
—
9
52
11
74
1.56
0.56
1.3
1.4
—
—
—
0
0
10
66
1.58
0.55
2.0
1.4
—
—
—
0
0
9
63
1.48
0.54
11.2
3.1
—
—
—
0
0
67
618
1.34
0.52
60.0
14.0
14.5
13.6
%
3.36
67
608
7
46
1.57
0.49
1.1
1.2
—
—
—
0
0
65
696
0.75
0.49
5.9
4.2
5.9
6.0
mmol/l
0.60
59
637
31
261
1.29
0.47
7.7
3.3
37.2
51.7
ng/l
0.38
26
173
7
49
1.46
0.47
4.3
3.8
—
—
—
0
0
14
180
0.74
0.42
6.4
3.9
—
—
—
0
0
73
765
0.75
0.40
40.9
10.9
—
—
—
0
0
77
733
1.37
0.40
58.5
11.4
27.2
22.5
mg/l
0.90
72
537
5
75
0.65
0.37
1.2
2.0
—
—
—
0
0
6
46
1.33
0.34
2.3
1.3
—
—
—
0
0
9
72
1.28
0.27
2.9
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
0.6
—
0
5
0
10
0.00
0.21
0.0
1.1
—
1.5
—
0
5
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
10
115
0.85
0.11
1.1
1.3
5.2
8.8
u/ml
—
5
36
70
685
1.10
0.09
45.2
13.0
34.2
40.4
%
3.82
55
517
11
123
0.88
0.08
1.0
1.3
17.5
35.5
iu/ml
—
5
43
9
88
1.03
0.07
1.1
1.1
—
—
—
0
0
76
767
0.94
0.02
56.8
12.7
111.4
76.0
umol/l
1.79
76
767
68
674
1.04
0.00
4.9
4.5
2.0
1.9
mu/l
0.43
63
621
6
60
1.00
0.00
1.2
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
3.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
6
67
0.89
0.00
1.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
3.2
—
2.2
—
0
5

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: CD2_OTHER_LEUKAEMIA_SPECIFIED_EXALLC – Other leukaemias of specified cell type

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).