This is a non-core endpoint: only basic statistics are computed.
Iodine-deficiency-related thyroid disorders and allied conditions
E4_IODTHYR
No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
36 |
4. Check minimum number of eventsNone |
36 |
5. Include endpointsNone |
36 |
6. Filter based on genotype QC (FinnGen only) |
36 |
Control definitions (FinnGen only)
- Control exclude
- E4_THYROID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E01
- Name in latin
- Aliae morbositates glandulae thyreoideae ex deficientia iodi et status cognati
Similar endpoints
↥List of similar endpoints to
Iodine-deficiency-related thyroid disorders and allied conditions
based on the number of shared cases.
Similar with more cases:
- Developmental endpoint to exclude non autoimmune-cases from E4_HYTHY_AI_STRICT
- Hypothyroidism (congenital or acquired)
- Hypothyreosis and Thyroxine purchase for inclusion criteria
- Disorders of the thyroid gland
- Used for control exclusion in common control thyroid runs
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 284 | 217 | 65 |
| Only index persons | 220 | 176 | 44 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.00 |
| Only index persons | 0.01 | 0.01 | 0.00 |
| Median age at first event (years) | |||
| Whole population | 65.85 | 65.17 | 67.92 |
| Only index persons | 59.04 | 60.79 | 52.06 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 36 | 30 | 6 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.00 |
| Median age at first event (years) | 56.43 | 53.67 | 70.25 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
No data available
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma
19
85
3.62
3.49
2.4
2.1
u/l
49.3
49.4
0.01
19
77
(40762366) Oxygen capacity [Volume Fraction] in Arterial blood
8
15
6.51
3.41
6.5
6.4
—
—
—
0
0
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
22
121
3.10
2.70
2.2
1.7
pmol/l
99.8
98.4
0.06
11
48
(3019060) Gas panel - Arterial blood
9
28
3.93
2.52
5.2
3.0
—
—
—
0
0
(3001122) Ferritin [Mass/volume] in Serum or Plasma
21
120
2.80
2.30
3.7
2.2
ug/l
96.8
106.5
0.13
21
110
(3016251) Hemoglobin.gastrointestinal [Presence] in Stool
6
14
4.91
2.25
2.0
2.1
—
—
—
0
0
(3019309) Folate [Moles/volume] in Red Blood Cells
14
65
2.89
2.24
2.3
1.7
nmol/l
1136.8
1315.2
0.51
14
47
(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma
30
214
3.40
2.20
8.4
2.7
pmol/l
15.8
14.6
2.88
30
188
(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma
15
73
2.81
2.20
1.8
1.9
pmol/l
456.1
501.1
0.22
15
58
(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal
6
16
4.27
2.03
1.2
1.1
—
—
—
0
0
(42870588) Differential panel, method unspecified - Blood
17
96
2.46
1.80
5.4
5.0
—
—
—
0
0
(4010399)
7
25
3.22
1.75
1.9
1.3
—
—
—
0
0
(36660697) Celiac disease serology panel - Serum
6
20
3.38
1.66
1.2
1.2
—
—
—
0
0
(3025839) Triglyceride [Moles/volume] in Serum or Plasma
16
92
2.33
1.59
1.9
1.7
mmol/l
1.3
1.4
0.09
16
79
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
0
38
0.00
1.44
0.0
4.1
—
—
—
0
0
(3006504) Eosinophils/100 leukocytes in Blood
21
142
2.15
1.36
9.4
5.5
%
2.6
2.5
0.04
21
132
(3037467) Urinalysis macro (dipstick) panel - Urine
27
206
2.24
1.30
9.6
4.5
—
—
—
0
0
(3019069) Monocytes/100 leukocytes in Blood
21
144
2.10
1.29
10.3
5.7
%
7.9
8.3
0.28
21
134
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
8
38
2.41
1.28
1.1
1.5
—
—
—
0
0
(3018010) Neutrophils/100 leukocytes in Blood
21
145
2.08
1.26
10.9
5.4
%
60.3
57.6
0.51
21
136
(3020779) Urea [Moles/volume] in Serum or Plasma
5
19
2.88
1.26
3.8
5.9
mmol/l
10.7
11.3
—
5
19
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
5
19
2.88
1.26
1.4
1.3
—
—
—
0
0
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
8
39
2.35
1.25
1.1
1.6
—
—
—
0
0
(3019225) pH of Specimen
7
31
2.55
1.18
7.3
3.4
—
—
—
0
0
(3022096) Basophils/100 leukocytes in Blood
20
138
2.01
1.18
8.3
5.6
%
0.7
0.6
0.10
20
126
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
10
53
2.23
1.15
1.2
1.6
—
—
—
0
0
(3002030) Lymphocytes/100 leukocytes in Blood
21
149
1.98
1.13
9.5
5.6
%
27.3
27.7
0.06
21
136
(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction
7
34
2.31
1.10
2.0
3.4
u/l
175.0
250.0
—
7
29
(40761536) Microorganisms panel - Urine sediment
0
28
0.00
1.03
0.0
4.9
—
—
—
0
0
(3004789) Transferrin [Mass/volume] in Serum or Plasma
8
47
1.90
0.88
2.4
1.9
g/l
2.5
2.4
—
8
40
(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)
0
27
0.00
0.81
0.0
3.3
—
74.7
—
0
9
(3004588) Protein electrophoresis panel - Serum or Plasma
5
25
2.16
0.76
1.4
1.5
—
—
—
0
0
(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma
5
25
2.16
0.76
1.4
4.1
u/ml
20.6
71.5
—
5
25
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
22
174
1.68
0.70
2.9
2.7
—
—
—
0
0
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
7
44
1.73
0.70
1.3
1.5
—
—
—
0
0
(3031040) Bacteria [#/volume] in Urine by Automated count
26
216
1.73
0.68
9.4
5.1
—
467.3
—
0
8
(1761868) Lipid panel - Serum or Plasma
6
99
0.53
0.63
2.0
2.8
—
—
—
0
0
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
18
138
1.61
0.63
6.3
4.1
—
—
—
0
0
(3026008) Bacteria identified in Urine by Culture
15
110
1.62
0.62
5.7
2.9
—
—
—
0
0
(3033319) Streptococcus pyogenes Ag [Presence] in Throat
0
20
0.00
0.62
0.0
1.4
—
—
—
0
0
(3016293) Bicarbonate [Moles/volume] in Serum or Plasma
0
19
0.00
0.62
0.0
4.6
—
25.7
—
0
19
(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood
0
19
0.00
0.62
0.0
6.4
—
1.5
—
0
19
(3006217) Methemoglobin/Hemoglobin.total in Arterial blood
0
19
0.00
0.62
0.0
6.4
—
0.9
—
0
19
(3007853) Bacteria identified in Skin by Aerobe culture
6
35
1.85
0.61
1.3
1.4
—
—
—
0
0
(3022621) pH of Urine by Test strip
0
23
0.00
0.60
0.0
2.4
—
—
—
0
0
(3022145) Colonoscopy Study observation
6
36
1.80
0.60
1.3
1.2
—
—
—
0
0
(3009201) Thyrotropin [Units/volume] in Serum or Plasma
31
276
1.88
0.53
10.1
3.5
mu/l
1.6
1.9
1.26
31
245
(3022948) Iron [Moles/volume] in Serum or Plasma
7
49
1.53
0.49
3.0
1.8
umol/l
10.6
12.3
—
7
43
(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma
28
248
1.58
0.47
12.5
6.8
u/l
91.7
77.9
0.39
28
231
(3044889) 12 lead EKG panel
24
207
1.48
0.43
3.5
3.8
—
—
—
0
0
(3018405) Lactate [Moles/volume] in Arterial blood
0
15
0.00
0.42
0.0
3.0
—
1.0
—
0
15
(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma
0
15
0.00
0.42
0.0
1.3
—
—
—
0
0
(3014007) Fractional oxyhemoglobin in Arterial blood
0
17
0.00
0.42
0.0
6.9
—
94.5
—
0
17
(3021879) Hepatitis B virus core Ab [Presence] in Serum
0
18
0.00
0.41
0.0
1.2
—
—
—
0
0
(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma
0
18
0.00
0.41
0.0
3.3
—
0.9
—
0
12
(36304419) Bacteria [Presence] in Urine
6
89
0.61
0.39
5.8
3.2
—
—
—
0
0
(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma
6
41
1.55
0.38
6.7
4.6
%
33.3
36.5
—
6
20
(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma
13
103
1.41
0.34
1.6
2.8
ng/l
227.5
1490.0
2.10
13
85
(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum
7
55
1.34
0.32
1.6
1.3
—
13.4
—
0
25
(40760892) CBC W Ordered Manual Differential panel - Blood
5
73
0.63
0.29
2.6
5.5
—
—
—
0
0
(3035350) Ketones [Presence] in Urine by Test strip
18
154
1.34
0.29
3.4
4.5
—
0.0
—
0
40
(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma
5
37
1.41
0.25
5.0
4.7
ug/l
67.2
1.8
—
5
31
(40768797) Stomach Pathology biopsy report
5
38
1.37
0.24
1.0
1.4
—
—
—
0
0
(3000494) Fungus identified in Specimen by Culture
5
40
1.29
0.23
1.2
1.3
—
—
—
0
0
(1616796) Gas panel - Central venous blood
0
11
0.00
0.22
0.0
3.6
—
—
—
0
0
(3020891) Body temperature
0
11
0.00
0.22
0.0
2.8
—
—
—
0
0
(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma
0
11
0.00
0.22
0.0
4.2
—
—
—
0
0
(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum
0
11
0.00
0.22
0.0
1.3
—
—
—
0
0
(3014765) Yersinia sp identified in Stool by Organism specific culture
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
(42529406) Shigella sp [Presence] in Stool by Culture
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
(3006418) Campylobacter sp identified in Tissue by Organism specific culture
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
(3000330) Specific gravity of Urine by Test strip
0
12
0.00
0.21
0.0
3.3
—
—
—
0
0
(3024354) Oxygen [Partial pressure] in Venous blood
0
13
0.00
0.21
0.0
3.1
—
3.8
—
0
13
(3011397) Hemoglobin [Presence] in Urine by Test strip
8
67
1.25
0.18
3.3
3.6
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
11
128
0.80
0.17
3.0
4.5
—
—
—
0
0
(3041096) Erythrocytes [Presence] in Urine by Automated
8
96
0.79
0.16
3.5
4.3
—
—
—
0
0
(3044640) Blood type and Crossmatch panel - Blood
8
95
0.80
0.16
3.5
2.1
—
—
—
0
0
(3023368) Bacteria identified in Blood by Culture
10
87
1.21
0.11
3.6
3.7
—
—
—
0
0
(40758558) Short blood count panel - Blood
10
87
1.21
0.11
8.5
7.0
—
—
—
0
0
(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma
14
127
1.17
0.10
3.2
4.3
ng/l
15.6
31.0
—
7
94
(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma
31
299
1.26
0.09
6.7
5.3
mmol/l
2.5
2.7
0.55
31
267
(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep
5
60
0.81
0.09
2.0
1.2
—
—
—
0
0
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
10
112
0.85
0.08
4.6
3.2
—
—
—
0
0
(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma
30
291
1.19
0.08
5.8
4.6
mmol/l
1.5
1.6
0.23
30
260
(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting
27
278
0.89
0.08
4.5
4.1
mmol/l
1.1
1.2
0.54
27
244
(3009542) Hematocrit [Volume Fraction] of Blood
26
259
1.01
0.00
29.9
14.0
%
34.9
38.7
0.53
16
177
(40768804) Tissue Pathology biopsy report
13
127
1.04
0.00
1.7
1.8
—
—
—
0
0
(3015736) pH of Urine
11
115
0.94
0.00
2.9
4.3
—
—
—
0
0
(3005570) Glucose [Moles/volume] in Urine
0
5
0.00
0.00
0.0
5.6
—
—
—
0
0
(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3020287) Protein C actual/normal in Platelet poor plasma by Coagulation assay
0
5
0.00
0.00
0.0
1.2
—
108.8
—
0
5
(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3023419) Bacteria identified in Sputum by Culture
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3028707) Methadone [Presence] in Urine by Screen method
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3022806) Fractional oxyhemoglobin in Capillary blood
0
5
0.00
0.00
0.0
1.0
—
91.1
—
0
5
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
6
66
0.89
0.00
3.3
1.9
—
—
—
0
0
(3026782) Osmolality of Urine
6
65
0.91
0.00
3.2
2.8
mosm/kgh2o
458.3
524.3
—
6
57
(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(4268621)
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
(44816559) Phosphatidylethanol [Mass/volume] in Blood
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3004616) Nuclear Ab [Presence] in Serum
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay
0
9
0.00
0.00
0.0
2.7
—
156.2
—
0
9
(3042111) Morphology [Interpretation] in Bone marrow Narrative
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3008037) Lactate [Moles/volume] in Venous blood
0
6
0.00
0.00
0.0
2.7
—
1.3
—
0
6
(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3013290) Carbon dioxide [Partial pressure] in Blood
0
9
0.00
0.00
0.0
2.7
—
4.9
—
0
9
(3021387) Prolactin [Units/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
1.0
—
282.4
—
0
7
(3044290) Cell count panel - Cerebral spinal fluid
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood
0
7
0.00
0.00
0.0
3.6
—
37.8
—
0
7
(3024889) Methemoglobin/Hemoglobin.total in Venous blood
0
7
0.00
0.00
0.0
3.1
—
0.6
—
0
7
(3014051) Protein [Presence] in Urine by Test strip
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
(3030905) Polymorphonuclear cells [#/volume] in Blood
0
7
0.00
0.00
0.0
1.9
—
7.0
—
0
7
(40768795) Lymph node Pathology biopsy report
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay
0
9
0.00
0.00
0.0
4.4
—
119.1
—
0
9
(36305247) Microscopic observation [Identifier] in Isolate by Gram stain
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
(3032035) Polymorphonuclear cells/100 leukocytes in Blood
0
7
0.00
0.00
0.0
4.3
—
66.4
—
0
7
(3023150) Myeloperoxidase Ab [Units/volume] in Serum
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay
0
9
0.00
0.00
0.0
1.7
—
3.3
—
0
9
(1761482) Bacteria [#/volume] in Urine by Culture
0
7
0.00
0.00
0.0
2.7
—
—
—
0
0
(3042631) Mycobacterium sp identified in Specimen
0
6
0.00
0.00
0.0
5.3
—
—
—
0
0
(3013512) EKG study
9
91
0.99
0.00
5.6
4.3
—
—
—
0
0
(3019900) Cholesterol [Moles/volume] in Serum or Plasma
30
293
1.14
0.00
5.5
4.7
mmol/l
4.5
4.6
0.36
30
263
(3005702) Mycobacterium sp identified in Specimen by Organism specific culture
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method
0
8
0.00
0.00
0.0
1.6
—
100.8
—
0
8
(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(4034850)
0
9
0.00
0.00
0.0
26.9
—
—
—
0
0
(4281824)
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
(3027315) Oxygen [Partial pressure] in Blood
0
9
0.00
0.00
0.0
2.7
—
7.8
—
0
9
(3004410) Hemoglobin A1c/Hemoglobin.total in Blood
29
288
1.04
0.00
7.5
5.9
mmol/mol
38.4
40.2
1.38
29
265
(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood
0
7
0.00
0.00
0.0
3.1
—
0.7
—
0
7
(3021901) Oxygen saturation in Capillary blood
0
6
0.00
0.00
0.0
3.8
—
—
—
0
0
(3038515) Glucose [Moles/volume] in Venous blood
0
6
0.00
0.00
0.0
2.7
—
7.5
—
0
6
(1617658) Protocol used for examination of sentinel lymph nodes
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_IODTHYR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_IODTHYR | 1.831 [1.35, 2.48] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.117 |
During the follow-up period (1.1.1998 — 31.12.2019), 84 out of 194 females with E4_IODTHYR died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have E4_IODTHYR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.144% | No data |
| 5 | 0.997% | No data |
| 10 | 2.579% | No data |
| 15 | 4.928% | No data |
| 20 | 8.476% | No data |
Relationships between endpoints
↥Index endpoint: E4_IODTHYR – Iodine-deficiency-related thyroid disorders and allied conditions
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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