Iodine-deficiency-related thyroid disorders and allied conditions

E4_IODTHYR

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E01.8 Cause of death: ICD-10 — E01.8 2 out of 7 registries used, show all original rules.	36
4. Check minimum number of events None	36
5. Include endpoints None	36
6. Filter based on genotype QC (FinnGen only)	36

Control definitions (FinnGen only)

Control exclude: E4_THYROID

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: E01
Name in latin: Aliae morbositates glandulae thyreoideae ex deficientia iodi et status cognati

NAME	E4_IODTHYR
CONTROL_EXCLUDE	E4_THYROID
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E018
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E018
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Iodine-deficiency-related thyroid disorders and allied conditions based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	284	217	65
Only index persons	220	176	44
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.00
Only index persons	0.01	0.01	0.00
Median age at first event (years)
Whole population	65.85	65.17	67.92
Only index persons	59.04	60.79	52.06

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	36	30	6
Unadjusted period prevalence (%)	0.01	0.01	0.00
Median age at first event (years)	56.43	53.67	70.25

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

3.62

3.49

2.4

2.1

49.3

49.4

u/l

0.01

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

6.51

3.41

6.5

6.4

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

121

3.10

2.70

2.2

1.7

99.8

98.4

pmol/l

0.06

(3019060) Gas panel - Arterial blood

3.93

2.52

5.2

3.0

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

120

2.80

2.30

3.7

2.2

96.8

106.5

ug/l

0.13

110

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

4.91

2.25

2.0

2.1

—

(3019309) Folate [Moles/volume] in Red Blood Cells

2.89

2.24

2.3

1.7

1136.8

1315.2

nmol/l

0.51

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

214

3.40

2.20

8.4

2.7

15.8

14.6

pmol/l

2.88

188

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

2.81

2.20

1.8

1.9

456.1

501.1

pmol/l

0.22

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

4.27

2.03

1.2

1.1

—

(42870588) Differential panel, method unspecified - Blood

2.46

1.80

5.4

5.0

—

(4010399)

3.22

1.75

1.9

1.3

—

(36660697) Celiac disease serology panel - Serum

3.38

1.66

1.2

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

2.33

1.59

1.9

1.7

1.3

1.4

mmol/l

0.09

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

0.00

1.44

0.0

4.1

—

(3006504) Eosinophils/100 leukocytes in Blood

142

2.15

1.36

9.4

5.5

2.6

2.5

0.04

132

(3037467) Urinalysis macro (dipstick) panel - Urine

206

2.24

1.30

9.6

4.5

—

(3019069) Monocytes/100 leukocytes in Blood

144

2.10

1.29

10.3

5.7

7.9

8.3

0.28

134

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.41

1.28

1.1

1.5

—

(3018010) Neutrophils/100 leukocytes in Blood

145

2.08

1.26

10.9

5.4

60.3

57.6

0.51

136

(3020779) Urea [Moles/volume] in Serum or Plasma

2.88

1.26

3.8

5.9

10.7

11.3

mmol/l

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.88

1.26

1.4

1.3

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.35

1.25

1.1

1.6

—

(3019225) pH of Specimen

2.55

1.18

7.3

3.4

—

(3022096) Basophils/100 leukocytes in Blood

138

2.01

1.18

8.3

5.6

0.7

0.6

0.10

126

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.23

1.15

1.2

1.6

—

(3002030) Lymphocytes/100 leukocytes in Blood

149

1.98

1.13

9.5

5.6

27.3

27.7

0.06

136

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

2.31

1.10

2.0

3.4

175.0

250.0

u/l

—

(40761536) Microorganisms panel - Urine sediment

0.00

1.03

0.0

4.9

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

1.90

0.88

2.4

1.9

2.5

2.4

g/l

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

0.00

0.81

0.0

3.3

—

74.7

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.16

0.76

1.4

1.5

—

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

2.16

0.76

1.4

4.1

20.6

71.5

u/ml

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

174

1.68

0.70

2.9

2.7

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.73

0.70

1.3

1.5

—

(3031040) Bacteria [#/volume] in Urine by Automated count

216

1.73

0.68

9.4

5.1

—

467.3

—

(1761868) Lipid panel - Serum or Plasma

0.53

0.63

2.0

2.8

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

138

1.61

0.63

6.3

4.1

—

(3026008) Bacteria identified in Urine by Culture

110

1.62

0.62

5.7

2.9

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.00

0.62

0.0

1.4

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

0.00

0.62

0.0

4.6

—

25.7

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

0.00

0.62

0.0

6.4

—

1.5

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

0.00

0.62

0.0

6.4

—

0.9

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.85

0.61

1.3

1.4

—

(3022621) pH of Urine by Test strip

0.00

0.60

0.0

2.4

—

(3022145) Colonoscopy Study observation

1.80

0.60

1.3

1.2

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

276

1.88

0.53

10.1

3.5

1.6

1.9

mu/l

1.26

245

(3022948) Iron [Moles/volume] in Serum or Plasma

1.53

0.49

3.0

1.8

10.6

12.3

umol/l

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

248

1.58

0.47

12.5

6.8

91.7

77.9

u/l

0.39

231

(3044889) 12 lead EKG panel

207

1.48

0.43

3.5

3.8

—

(3018405) Lactate [Moles/volume] in Arterial blood

0.00

0.42

0.0

3.0

—

1.0

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.42

0.0

1.3

—

(3014007) Fractional oxyhemoglobin in Arterial blood

0.00

0.42

0.0

6.9

—

94.5

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

0.00

0.41

0.0

1.2

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

0.00

0.41

0.0

3.3

—

0.9

—

(36304419) Bacteria [Presence] in Urine

0.61

0.39

5.8

3.2

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

1.55

0.38

6.7

4.6

33.3

36.5

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

103

1.41

0.34

1.6

2.8

227.5

1490.0

ng/l

2.10

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

1.34

0.32

1.6

1.3

—

13.4

—

(40760892) CBC W Ordered Manual Differential panel - Blood

0.63

0.29

2.6

5.5

—

(3035350) Ketones [Presence] in Urine by Test strip

154

1.34

0.29

3.4

4.5

—

0.0

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

1.41

0.25

5.0

4.7

67.2

1.8

ug/l

—

(40768797) Stomach Pathology biopsy report

1.37

0.24

1.0

1.4

—

(3000494) Fungus identified in Specimen by Culture

1.29

0.23

1.2

1.3

—

(1616796) Gas panel - Central venous blood

0.00

0.22

0.0

3.6

—

(3020891) Body temperature

0.00

0.22

0.0

2.8

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.22

0.0

4.2

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

0.00

0.22

0.0

1.3

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

0.00

0.21

0.0

1.0

—

(42529406) Shigella sp [Presence] in Stool by Culture

0.00

0.21

0.0

1.0

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

0.00

0.21

0.0

1.0

—

(3000330) Specific gravity of Urine by Test strip

0.00

0.21

0.0

3.3

—

(3024354) Oxygen [Partial pressure] in Venous blood

0.00

0.21

0.0

3.1

—

3.8

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.25

0.18

3.3

3.6

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

128

0.80

0.17

3.0

4.5

—

(3041096) Erythrocytes [Presence] in Urine by Automated

0.79

0.16

3.5

4.3

—

(3044640) Blood type and Crossmatch panel - Blood

0.80

0.16

3.5

2.1

—

(3023368) Bacteria identified in Blood by Culture

1.21

0.11

3.6

3.7

—

(40758558) Short blood count panel - Blood

1.21

0.11

8.5

7.0

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

127

1.17

0.10

3.2

4.3

15.6

31.0

ng/l

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

299

1.26

0.09

6.7

5.3

2.5

2.7

mmol/l

0.55

267

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.81

0.09

2.0

1.2

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

112

0.85

0.08

4.6

3.2

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

291

1.19

0.08

5.8

4.6

1.5

1.6

mmol/l

0.23

260

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

278

0.89

0.08

4.5

4.1

1.1

1.2

mmol/l

0.54

244

(3009542) Hematocrit [Volume Fraction] of Blood

259

1.01

0.00

29.9

14.0

34.9

38.7

0.53

177

(40768804) Tissue Pathology biopsy report

127

1.04

0.00

1.7

1.8

—

(3015736) pH of Urine

115

0.94

0.00

2.9

4.3

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

5.6

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.0

—

(3020287) Protein C actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.2

—

108.8

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.0

1.2

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.0

2.2

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.0

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

0.0

1.2

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.0

1.0

—

91.1

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

0.89

0.00

3.3

1.9

—

(3026782) Osmolality of Urine

0.91

0.00

3.2

2.8

458.3

524.3

mosm/kgh2o

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(4268621)

0.00

0.0

2.0

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.0

1.4

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.0

1.2

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

2.7

—

156.2

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

0.0

1.2

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.0

2.7

—

1.3

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.3

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.0

2.7

—

4.9

—

(3021387) Prolactin [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

282.4

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.0

1.0

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

0.00

0.0

3.6

—

37.8

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

0.00

0.0

3.1

—

0.6

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.0

1.9

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

0.00

0.0

1.9

—

7.0

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.0

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

4.4

—

119.1

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

0.00

0.0

1.4

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

0.00

0.0

4.3

—

66.4

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

0.00

0.0

1.7

—

3.3

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.0

2.7

—

(3042631) Mycobacterium sp identified in Specimen

0.00

0.0

5.3

—

(3013512) EKG study

0.99

0.00

5.6

4.3

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

293

1.14

0.00

5.5

4.7

4.5

4.6

mmol/l

0.36

263

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

0.00

0.0

1.6

—

100.8

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

0.00

0.0

1.2

—

(4034850)

0.00

0.0

26.9

—

(4281824)

0.00

0.0

1.0

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.0

1.6

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.0

2.7

—

7.8

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

288

1.04

0.00

7.5

5.9

38.4

40.2

mmol/mol

1.38

265

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

0.00

0.0

3.1

—

0.7

—

(3021901) Oxygen saturation in Capillary blood

0.00

0.0

3.8

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.0

2.7

—

7.5

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint E4_IODTHYR and mortality.

Females

Parameter	HR [95% CI]	p-value
E4_IODTHYR	1.831 [1.35, 2.48]	< 0.001
Birth year	0.993 [0.98, 1.0]	0.117

During the follow-up period (1.1.1998 — 31.12.2019), 84 out of 194 females with E4_IODTHYR died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_IODTHYR.

N-year risk	Females	Males
1	0.144%	No data
5	0.997%	No data
10	2.579%	No data
15	4.928%	No data
20	8.476%	No data

Relationships between endpoints

↥

Index endpoint: E4_IODTHYR – Iodine-deficiency-related thyroid disorders and allied conditions

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Iodine-deficiency-related thyroid disorders and allied conditions

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints