Enterohaemorrhagic Escherichia coli infection

EHEC

dysentery: Acute inflammation of the intestine associated with infectious diarrhea of various etiologies, generally acquired by eating contaminated food containing toxins, biological derived from bacteria or other microorganisms. Dysentery is characterized initially by watery feces then by bloody mucoid stools. It is often associated with abdominal pain; fever; and dehydration.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — A04.3 Cause of death: ICD-10 — A04.3 2 out of 7 registries used, show all original rules.	61
4. Check minimum number of events None	61
5. Include endpoints None	61
6. Filter based on genotype QC (FinnGen only)	61

Control definitions (FinnGen only)

Control exclude: IBD_BACT_INTEST_INFECTIONS

Extra metadata

First used in FinnGen datafreeze: DF2
Parent code in ICD-10: A04
Name in latin: Infectio ab Escherichia coli enterohaemorrhagica

NAME	EHEC
CONTROL_EXCLUDE	IBD_BACT_INTEST_INFECTIONS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	A043
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	A043
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Enterohaemorrhagic Escherichia coli infection based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	663	320	339
Only index persons	530	259	271
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	18.74	22.76	14.55
Only index persons	26.35	31.04	21.86

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	61	38	23
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	54.07	54.06	54.07

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
54: Matched controls
541

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

A04.3

ICD-10 Finland

Enterohaemorrhagic Escherichia coli infection

+∞

72.1

A09

ICD-10 Finland

Other gastroenteritis and colitis of infectious and unspecified origin

10.9

13.9

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

19.57

17.36

3.3

1.4

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

11.79

16.86

3.6

1.4

—

(3023368) Bacteria identified in Blood by Culture

5.46

9.94

8.0

5.0

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

26.92

9.83

2.1

1.2

—

(3003327) Ova and parasites identified in Stool by Light microscopy

8.42

8.82

2.6

1.4

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

8.35

6.92

3.3

2.1

—

(3020779) Urea [Moles/volume] in Serum or Plasma

5.63

6.06

10.2

9.5

9.0

7.4

mmol/l

0.34

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

5.88

5.49

2.7

1.3

—

(3025941) Bacteria identified in Stool by Culture

5.06

5.40

2.1

1.2

—

(3048689) Calprotectin [Mass/mass] in Stool

3.80

5.31

3.5

1.7

379.6

121.2

ug/g

0.93

(42870588) Differential panel, method unspecified - Blood

149

3.41

5.28

12.6

5.8

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

15.05

5.24

3.6

1.7

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

15.05

5.24

3.6

1.7

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

11.27

4.67

2.1

1.6

—

(3019060) Gas panel - Arterial blood

4.57

4.50

13.4

19.4

—

(3018010) Neutrophils/100 leukocytes in Blood

229

3.17

4.43

12.7

6.1

61.2

57.4

1.05

221

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

12.94

4.39

4.0

1.7

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

12.94

4.39

4.0

1.7

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

12.94

4.39

4.0

1.7

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

12.94

4.39

4.0

1.7

—

(3002030) Lymphocytes/100 leukocytes in Blood

232

3.10

4.27

13.1

6.1

23.9

28.1

1.59

222

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

8.99

4.20

2.4

1.6

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

8.99

4.20

2.5

1.6

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

4.15

4.00

1.9

1.2

—

(3022313) Gas panel - Capillary blood

8.17

4.00

3.6

1.8

—

(3022145) Colonoscopy Study observation

3.74

3.94

1.9

1.3

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

150

2.78

3.69

5.7

2.8

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

3.03

3.31

2.6

1.8

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

7.02

3.28

2.9

2.7

3.5

3.8

g/l

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

5.58

3.17

2.1

1.1

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

247

2.61

3.16

12.1

6.3

11.1

10.3

umol/l

0.21

234

(36660697) Celiac disease serology panel - Serum

3.32

3.15

1.5

1.0

—

(42529406) Shigella sp [Presence] in Stool by Culture

5.24

3.03

2.1

1.1

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

5.24

3.03

2.1

1.1

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

10.72

3.03

1.6

1.2

—

(40758558) Short blood count panel - Blood

115

2.61

3.03

16.0

6.4

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

5.92

2.96

1.6

1.3

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

5.92

2.96

1.6

1.3

—

(3044640) Blood type and Crossmatch panel - Blood

141

2.47

2.87

3.9

2.2

—

(40768797) Stomach Pathology biopsy report

3.01

2.85

1.6

1.2

—

(3026782) Osmolality of Urine

2.70

2.82

3.5

2.3

563.7

567.1

mosm/kgh2o

0.02

(3042936) Bacteria identified in Isolate by Culture

2.88

2.80

2.7

2.5

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

8.93

2.80

1.4

3.7

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

8.93

2.80

2.2

1.0

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

8.93

2.80

1.4

1.3

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

161

2.37

2.68

5.3

3.4

29.5

27.4

u/l

0.24

154

(36304419) Bacteria [Presence] in Urine

121

2.45

2.68

5.6

2.6

—

(3023419) Bacteria identified in Sputum by Culture

7.64

2.59

5.2

2.9

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

7.64

2.59

3.0

1.7

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

7.64

2.59

2.8

1.7

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

3.13

2.53

3.0

1.8

353.1

426.5

nmol/l

0.50

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

5.41

2.46

1.7

1.2

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

4.50

2.44

1.9

1.6

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

127

2.30

2.37

2.2

109.2

139.7

u/l

0.66

122

(3024561) Albumin [Mass/volume] in Serum or Plasma

169

2.21

2.33

11.4

5.1

32.6

35.9

g/l

1.69

164

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

2.36

2.27

4.6

2.4

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

5.93

2.25

3.2

1.7

—

(3037467) Urinalysis macro (dipstick) panel - Urine

344

2.37

2.20

5.8

4.1

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

149

2.15

2.11

5.8

2.5

48.0

59.5

u/l

1.15

142

(3000494) Fungus identified in Specimen by Culture

2.58

2.08

1.8

1.9

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.76

2.06

2.4

1.5

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

3.62

2.03

1.6

1.2

—

(3000850) Epithelial cells [#/volume] in Urine

2.27

2.02

5.3

2.2

6.1

4.4

e6/l

0.36

(3001019) Free T4 and TSH panel - Serum or Plasma

3.25

2.02

1.8

1.3

—

(3021447) Carbon dioxide [Partial pressure] in Venous blood

2.79

1.95

6.7

2.1

5.6

kpa

—

(3000991) Gas panel - Venous blood

3.13

1.94

7.9

9.7

—

(40768443) Skin Pathology biopsy report

3.79

1.89

1.0

1.1

—

(3032080) INR in Blood by Coagulation assay

163

2.04

1.89

8.3

7.4

1.2

inr

—

(3002032) Base excess in Venous blood by calculation

2.72

1.86

6.7

2.1

1.7

2.3

mmol/l

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.58

1.83

2.5

1.5

—

(3018418) pH of Serum or Plasma

123

2.08

1.81

13.2

3.1

7.4

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

3.03

1.70

8.0

10.2

1.4

1.3

mmol/l

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

3.79

1.65

18.0

7.7

25.4

24.6

mmol/l

—

(3012516) Albumin [Mass/volume] in Urine

103

2.06

1.63

3.3

2.9

64.6

83.3

mg/l

—

(3012544) pH of Venous blood

2.52

1.63

6.9

2.5

—

(3024354) Oxygen [Partial pressure] in Venous blood

2.63

1.60

7.5

2.2

4.8

5.1

kpa

—

(4035726)

2.79

1.56

2.6

1.3

—

(3015736) pH of Urine

199

1.87

1.56

4.7

3.6

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

2.24

1.50

3.1

2.0

21.1

23.9

0.13

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.31

1.49

1.5

1.6

—

(3007164) IgA [Mass/volume] in Serum or Plasma

124

1.91

1.44

1.8

1.2

1.8

2.2

g/l

0.72

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

167

1.84

1.44

5.6

4.2

21.7

40.5

ng/l

0.70

110

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

169

1.81

1.38

2.4

1.9

81.0

95.5

pmol/l

0.85

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

449

2.07

1.34

24.6

10.8

90.1

89.2

ml/min/173m2

0.08

353

(3022948) Iron [Moles/volume] in Serum or Plasma

2.06

1.31

3.2

1.9

10.6

14.7

umol/l

0.77

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

2.93

1.31

1.6

1.7

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.93

1.31

2.2

2.1

—

(4010399)

2.40

1.30

1.1

1.4

—

(3022621) pH of Urine by Test strip

2.33

1.27

3.6

3.1

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.77

1.24

2.8

2.3

—

(3019225) pH of Specimen

2.27

1.24

4.1

3.6

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

2.05

1.24

3.7

1.9

2.5

2.4

g/l

0.02

(3002385) Erythrocyte distribution width [Ratio]

429

1.92

1.11

32.7

15.3

14.0

13.4

1.42

419

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.84

1.10

1.9

1.6

—

(3035350) Ketones [Presence] in Urine by Test strip

245

1.64

1.07

5.9

3.9

0.0

estimate

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

387

1.77

1.07

3.7

3.8

14.9

14.7

pmol/l

0.15

354

(3021589) Normoblasts [#/volume] in Blood

208

1.64

1.05

26.4

8.8

0.0

e9/l

0.00

167

(40760892) CBC W Ordered Manual Differential panel - Blood

119

1.73

1.03

7.8

5.3

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

389

1.74

1.03

3.7

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

111

1.74

1.02

4.0

4.2

—

(3009508) Creatinine [Moles/volume] in Urine

129

1.69

0.99

3.8

2.6

7.4

8.1

mmol/l

0.26

114

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

2.35

0.96

1.2

1.3

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.90

0.90

3.7

8.5

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

2.03

0.87

2.5

—

(3021601) Nitrite [Presence] in Urine by Test strip

246

1.53

0.83

9.4

5.3

0.0

estimate

—

(3029937) Albumin [Presence] in Urine by Test strip

144

1.58

0.82

4.3

3.9

0.0

estimate

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.81

0.0

1.5

—

(3026008) Bacteria identified in Urine by Culture

127

1.59

0.80

3.4

3.2

—

(3000330) Specific gravity of Urine by Test strip

2.27

0.78

2.2

2.5

—

(3002256) Pathology report gross observation

1.74

0.78

1.7

1.1

—

(3014007) Fractional oxyhemoglobin in Arterial blood

2.18

0.76

2.0

11.9

82.2

93.0

—

(3020682) Albumin/Creatinine [Ratio] in Urine

111

1.60

0.76

4.3

3.7

6.6

14.6

mg/mmol

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

1.65

0.74

1.6

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

223

1.47

0.71

6.6

4.9

—

(3009261) Glucose [Presence] in Urine by Test strip

253

1.46

0.69

6.4

3.9

0.0

estimate

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

114

1.55

0.68

2.1

2.3

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.58

0.66

1.6

1.5

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

1.79

0.65

11.4

2.8

117.2

129.7

g/l

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

133

1.50

0.65

1.7

1.2

0.3

0.7

u/ml

—

(3009542) Hematocrit [Volume Fraction] of Blood

464

1.60

0.62

25.2

13.4

38.9

40.5

0.76

365

(21494755) Public health laboratory ask at order entry panel

1.55

0.60

1.5

1.2

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.69

0.57

1.0

—

(3041096) Erythrocytes [Presence] in Urine by Automated

149

1.40

0.50

6.4

3.1

—

(3013512) EKG study

124

1.39

0.44

5.1

3.7

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

124

1.39

0.44

1.8

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

200

1.33

0.43

6.3

3.9

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

125

1.38

0.42

1.8

1.6

—

(40761535) Cells panel - Urine sediment

1.56

0.42

4.2

4.0

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.51

0.41

1.0

1.1

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

1.47

0.37

1.7

1.3

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

128

1.34

0.37

2.1

1.7

1.3

mmol/l

0.72

115

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

103

1.33

0.31

2.0

2.2

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

0.00

0.21

0.0

1.3

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.21

0.0

2.4

—

(4094501)

0.00

0.21

0.0

1.3

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.21

0.0

2.0

—

4.1

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.21

0.0

2.0

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.21

0.0

2.0

—

106.3

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.21

0.0

2.1

—

1.5

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.21

0.0

2.1

—

7.6

—

(3003694) ABO and Rh group [Type] in Blood

160

1.18

0.16

1.7

1.6

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

163

1.15

0.12

2.2

2.0

—

(3000492) Spirometry study

1.12

0.10

2.0

1.3

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.06

0.09

2.5

1.5

—

(3019832) Treponema pallidum Ab [Presence] in Serum

107

0.92

0.02

1.3

1.7

—

(40768804) Tissue Pathology biopsy report

177

0.95

0.01

3.1

1.8

—

(3044889) 12 lead EKG panel

325

1.03

0.00

4.5

3.3

—

(1761868) Lipid panel - Serum or Plasma

186

1.03

0.00

2.3

2.4

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.0

1.3

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.3

—

(3034603) RHD gene allele [Genotype] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.0

1.2

—

(3023420) DNA double strand Ab [Units/volume] in Serum

0.00

0.0

1.6

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

5.4

—

832.3

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.2

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.0

1.6

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

4.1

—

593.4

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3019497) Choriogonadotropin.beta subunit free [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.96

0.00

2.3

2.4

—

(3018658) Beta 2 glycoprotein 1 IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

3.1

—

2.5

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.0

1.1

—

(3005082) Progesterone [Moles/volume] in Serum or Plasma

0.00

0.0

1.4

—

27.3

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

0.95

0.00

6.6

2.9

10.9

292.6

ng/l

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.03

0.00

1.9

1.5

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.0

2.0

—

(3014326) Insulin-like growth factor-I [Moles/volume] in Serum or Plasma

0.00

0.0

1.8

—

30.3

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.0

1.4

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.90

0.00

1.8

2.2

—

(4281824)

0.00

0.0

1.0

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

130.1

—

Mortality – FinRegistry

↥

Association

Association between endpoint EHEC and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have EHEC.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: EHEC – Enterohaemorrhagic Escherichia coli infection

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Enterohaemorrhagic Escherichia coli infection

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints