Other changes in lacrimal passages

H7_LACRIPAS

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H04.6 Hospital discharge: ICD-9 — 3756 Hospital discharge: ICD-8 — 36805 Cause of death: ICD-10 — H04.6 Cause of death: ICD-9 — 3756 Cause of death: ICD-8 — 36805 2 out of 7 registries used, show all original rules.	48
4. Check minimum number of events None	48
5. Include endpoints None	48
6. Filter based on genotype QC (FinnGen only)	48

Control definitions (FinnGen only)

Control exclude: H7_LIDLACRIMALORBIT

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: H04
Name in latin: Aliae morbositates apparati lacrimalis

NAME	H7_LACRIPAS
CONTROL_EXCLUDE	H7_LIDLACRIMALORBIT
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H046
HD_ICD_9	3756
HD_ICD_8	36805
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H046
COD_ICD_9	3756
COD_ICD_8	36805
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Other changes in lacrimal passages based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	334	214	120
Only index persons	291	191	100
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.00
Only index persons	0.01	0.01	0.00
Median age at first event (years)
Whole population	-	54.59	38.23
Only index persons	49.58	54.40	40.38

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	48	42	6
Unadjusted period prevalence (%)	0.01	0.01	0.00
Median age at first event (years)	52.29	54.91	33.90

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3007853) Bacteria identified in Skin by Aerobe culture

4.12

4.60

2.4

1.4

—

(3015171) Extractable nuclear Ab [Units/volume] in Serum

7.23

3.31

1.3

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

5.77

3.20

1.9

1.4

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

4.93

2.58

2.0

1.2

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

239

2.71

2.44

11.9

9.7

4.6

4.1

e9/l

0.49

209

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

2.75

2.42

2.9

9.1

43.1

ng/l

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

132

2.43

2.29

4.0

2.7

26.4

28.4

u/l

0.37

124

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

2.58

2.23

1.7

1.5

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

246

2.56

2.18

3.4

2.7

42.1

45.1

u/l

0.11

228

(3000492) Spirometry study

3.22

2.13

1.3

1.6

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

4.41

2.11

3.5

1.9

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

2.50

2.10

6.8

3.8

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

2.39

1.93

1.3

26.9

33.3

iu/ml

—

(3002256) Pathology report gross observation

2.62

1.79

1.4

1.1

—

(3013707) Erythrocyte sedimentation rate by Westergren method

308

2.42

1.77

4.8

4.1

11.9

12.1

mm/h

0.05

276

(42870588) Differential panel, method unspecified - Blood

127

2.16

1.76

8.6

4.2

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

321

2.47

1.66

5.0

4.4

14.9

pmol/l

0.01

283

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

139

2.08

1.62

5.9

2.8

—

(3021601) Nitrite [Presence] in Urine by Test strip

195

2.05

1.57

9.1

5.1

0.0

estimate

—

(3035350) Ketones [Presence] in Urine by Test strip

196

2.03

1.54

7.0

3.8

0.0

estimate

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

2.96

1.48

2.2

1.2

—

(3018095) Leukocytes [#/volume] in Urine

143

1.99

1.47

6.0

4.2

26.0

58.3

e6/l

0.59

102

(3002385) Erythrocyte distribution width [Ratio]

352

2.54

1.45

24.5

16.1

13.8

13.7

0.00

345

(3009261) Glucose [Presence] in Urine by Test strip

199

1.98

1.45

7.1

3.7

0.0

estimate

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

210

1.96

1.40

6.4

6.5

10.8

9.5

umol/l

0.42

195

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.37

1.39

1.7

—

(3019060) Gas panel - Arterial blood

2.71

1.35

3.5

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

2.10

1.31

3.5

2.6

1.9

0.6

e6/l

—

(40758558) Short blood count panel - Blood

113

1.95

1.30

12.2

6.0

—

(36304419) Bacteria [Presence] in Urine

113

1.95

1.30

4.8

2.8

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

122

1.92

1.29

3.8

2.2

88.8

135.7

u/l

0.66

113

(3004588) Protein electrophoresis panel - Serum or Plasma

2.59

1.28

3.7

2.0

—

(3045414) Leukocytes [Presence] in Urine

2.67

1.18

2.4

1.7

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.39

1.13

1.7

—

(3021447) Carbon dioxide [Partial pressure] in Venous blood

2.24

1.08

3.0

2.3

6.1

5.7

kpa

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

367

2.15

0.99

6.1

5.1

39.7

39.2

mmol/mol

0.12

337

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.78

0.91

1.9

2.0

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.83

0.88

2.0

1.9

—

(3015736) pH of Urine

156

1.62

0.80

6.8

3.3

—

(3000494) Fungus identified in Specimen by Culture

1.78

0.79

1.4

1.3

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

1.73

0.79

1.2

11.6

u/ml

—

(3000991) Gas panel - Venous blood

2.31

0.79

3.0

3.1

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

2.31

0.79

3.0

2.7

1.1

1.2

mmol/l

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.98

0.78

1.3

1.4

—

(3024354) Oxygen [Partial pressure] in Venous blood

2.03

0.73

3.8

2.3

4.4

4.3

kpa

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

377

1.91

0.72

18.9

13.1

83.2

82.0

ml/min/173m2

0.13

303

(3007164) IgA [Mass/volume] in Serum or Plasma

1.65

0.70

1.8

1.4

2.8

g/l

—

(3023368) Bacteria identified in Blood by Culture

1.63

0.69

9.9

4.0

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

1.68

0.66

4.1

2.6

1.2

2.7

e6/l

—

(3044889) 12 lead EKG panel

281

1.56

0.65

5.0

3.4

—

(40768804) Tissue Pathology biopsy report

172

1.52

0.65

2.0

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

163

1.51

0.64

2.2

1.8

111.5

102.2

pmol/l

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

1.58

0.61

1.9

2.5

2.7

2.5

g/l

—

(3012544) pH of Venous blood

1.76

0.59

3.3

2.5

—

(3026008) Bacteria identified in Urine by Culture

147

1.48

0.57

5.8

3.0

—

(3037467) Urinalysis macro (dipstick) panel - Urine

287

1.48

0.54

6.7

4.4

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

178

1.44

0.52

3.6

2.6

211.1

75.3

ug/l

0.60

164

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

189

1.42

0.50

5.6

5.5

1.2

mmol/l

0.89

156

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

161

1.42

0.48

7.9

3.5

—

(3032080) INR in Blood by Coagulation assay

153

1.40

0.45

11.9

6.7

1.4

1.2

inr

—

(3042936) Bacteria identified in Isolate by Culture

1.43

0.44

2.1

2.0

—

(36660697) Celiac disease serology panel - Serum

1.63

0.44

1.4

1.1

—

(3029937) Albumin [Presence] in Urine by Test strip

107

1.44

0.43

9.1

3.9

0.0

estimate

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.42

0.0

1.7

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.42

0.0

1.4

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

264

1.36

0.40

3.8

3.3

—

(3012516) Albumin [Mass/volume] in Urine

1.42

0.38

3.5

2.9

7858.7

46.4

mg/l

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.53

0.38

3.0

1.4

—

(3022145) Colonoscopy Study observation

1.49

0.37

1.3

1.2

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

150

1.32

0.33

8.4

3.8

13.2

61.2

ng/l

0.96

101

(3013512) EKG study

122

1.33

0.32

5.7

3.5

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.32

0.31

1.4

1.7

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.32

0.30

2.5

1.6

—

(3044640) Blood type and Crossmatch panel - Blood

116

1.29

0.26

3.9

1.8

—

(3003694) ABO and Rh group [Type] in Blood

124

0.76

0.25

1.3

1.5

—

(3026493) Urate [Moles/volume] in Serum or Plasma

107

1.29

0.25

2.8

2.5

293.9

3956.7

umol/l

0.50

(40761536) Microorganisms panel - Urine sediment

1.39

0.24

7.6

3.5

—

(3020682) Albumin/Creatinine [Ratio] in Urine

1.30

0.24

3.4

3.9

4.8

7.3

mg/mmol

—

(3027801) Oxygen [Partial pressure] in Arterial blood

1.31

0.24

4.8

3.7

9.1

12.9

kpa

—

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

1.31

0.24

4.8

3.7

5.3

kpa

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.24

0.23

3.2

1.4

—

(3009041) Cardiolipin IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.0

—

4.5

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.21

0.0

1.5

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.21

0.0

1.0

—

(3021901) Oxygen saturation in Capillary blood

0.00

0.21

0.0

2.9

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

3.5

—

26.6

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

0.00

0.21

0.0

1.5

—

(3037756) Immunofixation for Serum or Plasma

0.00

0.21

0.0

1.4

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.21

0.0

1.0

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.21

0.0

3.5

—

(40766189) Gliadin peptide IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.0

—

1.3

—

(3021387) Prolactin [Units/volume] in Serum or Plasma

0.00

0.20

0.0

1.8

—

293.9

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.20

0.20

1.3

1.8

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.21

0.17

3.9

1.8

—

(3041096) Erythrocytes [Presence] in Urine by Automated

125

1.17

0.12

5.5

3.2

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.13

0.09

1.8

—

(40768797) Stomach Pathology biopsy report

1.13

0.09

2.3

1.2

—

(3009542) Hematocrit [Volume Fraction] of Blood

368

1.16

0.08

24.3

13.0

39.7

39.6

0.04

257

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

197

1.12

0.08

5.4

3.8

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.14

0.06

1.5

1.4

—

(1761868) Lipid panel - Serum or Plasma

149

0.91

0.04

2.6

2.9

—

(40760892) CBC W Ordered Manual Differential panel - Blood

101

0.99

0.00

4.5

4.8

—

(3021960) Folate [Moles/volume] in Serum or Plasma

102

0.98

0.00

1.7

1.4

12.8

24.1

nmol/l

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.0

1.3

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3006257) Acetylcholine receptor Ab [Moles/volume] in Serum

0.00

0.0

1.4

—

(3016038) Potassium [Moles/volume] in Urine

0.00

0.0

1.0

—

32.6

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.0

1.4

—

(3012413) Glucose [Moles/volume] in Serum or Plasma --2 hours post meal

0.00

0.0

1.7

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(4281824)

0.00

0.0

1.0

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.2

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.0

2.6

—

3.9

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.2

—

(4268621)

0.00

0.0

1.8

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.0

1.0

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

0.0

1.0

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

1.6

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.0

2.6

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.0

1.7

—

31.3

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

0.00

0.0

1.3

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(42529215) Follitropin [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

1.7

—

19.0

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.0

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.0

1.3

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.0

1.3

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.0

2.6

—

108.6

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3048689) Calprotectin [Mass/mass] in Stool

0.92

0.00

4.8

1.6

54.6

159.2

ug/g

—

(3019309) Folate [Moles/volume] in Red Blood Cells

1.01

0.00

3.0

1.6

1484.0

1181.5

nmol/l

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

0.0

1.4

—

17.4

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

0.00

0.0

1.1

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(40768806) Pleura Pathology biopsy report

0.00

0.0

1.0

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.04

0.00

2.3

2.2

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.0

2.4

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.0

1.3

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint H7_LACRIPAS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H7_LACRIPAS.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

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Index endpoint: H7_LACRIPAS – Other changes in lacrimal passages

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other changes in lacrimal passages

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints