Diaper [napkin] dermatitis

L12_DIAPER

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L22
  • Hospital discharge: ICD-9 6910
  • Cause of death: ICD-10 L22
  • Cause of death: ICD-9 6910

2 out of 7 registries used, show all original rules.

60

4. Check minimum number of events

None

60

5. Include endpoints

None

60

6. Filter based on genotype QC (FinnGen only)

54

Control definitions (FinnGen only)

Control exclude
L12_DERMATITISECZEMA

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L20-L30
Name in latin
Dermatitis glutealis infantum

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1887 1086 800
Only index persons 809 478 331
Unadjusted period prevalence (%)
Whole population 0.03 0.03 0.02
Only index persons 0.02 0.02 0.01
Median age at first event (years)
Whole population 1.03 1.01 0.96
Only index persons 1.14 1.10 1.21

-FinnGen-

Key figures

All Female Male
Number of individuals 54 36 18
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 2.42 2.28 2.71

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
60
Matched controls
600
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L22
ICD-10 Finland
Diaper [napkin] dermatitis
+∞
61.3
48
*
L20.0
ICD-10 Finland
Besnier prurigo
+∞
13.0
12
*
6910A
ICD-9 Finland
Atopic dermatitis and related conditions, Diaper or napkin rash
+∞
11.8
11
*
E0000UV, ,
ATC
5.0
8.7
37
146
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
14.6
6.9
11
9
A28
ICPC
Limited function/disability NOS
5.2
6.6
16
39
TQW80
NOMESCO Finland
Local dermatologic skincare
+∞
6.4
6
*
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
+∞
6.4
6
*
L27.2
ICD-10 Finland
Dermatitis due to ingested food
+∞
6.4
6
*
D07AA02
ATC
hydrocortisone; topical
4.9
6.3
17
45

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
30
137
3.38
5.09
5.7
11.9
—
—
—
0
0
18
70
3.24
3.81
10.1
13.9
—
—
—
0
0
9
18
5.68
3.53
1.1
1.2
—
—
—
0
0
11
33
3.85
3.00
2.2
2.5
—
—
—
0
0
15
60
3.00
2.98
2.8
1.9
—
—
—
0
0
6
9
7.25
2.94
7.5
39.9
—
—
—
0
0
14
55
3.02
2.86
3.4
4.1
1160.89
539.59
ng/l
—
9
34
7
14
5.50
2.82
1.3
6.2
4.14
3.34
mmol/l
—
7
14
24
130
2.41
2.63
6.3
2.6
—
—
—
0
0
17
78
2.65
2.62
10.4
13.0
—
—
—
0
0
5
7
7.65
2.60
5.4
5.7
13.54
10.70
mg/l
—
5
7
25
139
2.37
2.58
5.3
4.0
0.04
0.15
e6/l
0.94
19
111
8
21
4.23
2.56
9.5
3.4
—
—
—
0
0
7
16
4.80
2.56
1.3
5.6
375.57
624.13
mg/l
—
7
16
18
90
2.43
2.31
5.7
4.8
—
—
—
0
0
26
153
2.23
2.31
5.3
4.3
25.23
424.09
e6/l
0.49
20
122
5
9
5.94
2.26
1.2
6.3
—
—
—
0
0
40
289
2.15
2.03
11.2
12.0
3.73
3.82
e9/l
0.12
35
235
11
46
2.70
1.98
1.8
1.4
—
—
—
0
0
5
11
4.85
1.98
1.6
1.2
—
—
—
0
0
29
188
2.05
1.94
6.2
7.8
9.66
20.26
umol/l
2.74
29
175
12
54
2.53
1.88
2.4
2.3
—
—
—
0
0
23
140
2.04
1.80
5.5
4.0
—
—
—
0
0
5
13
4.09
1.75
1.4
6.7
—
—
—
0
0
6
19
3.39
1.71
10.8
16.9
0.60
0.66
%
—
6
19
17
94
2.13
1.69
1.5
3.4
1.43
1.39
mg/l
0.02
11
68
15
79
2.20
1.68
13.1
15.2
25.67
24.89
mmol/l
0.28
15
79
6
20
3.21
1.62
10.8
16.1
1.18
1.02
%
—
6
20
8
33
2.64
1.60
1.4
1.7
—
—
—
0
0
22
142
1.87
1.41
1.6
1.8
1.89
2.16
g/l
0.24
15
81
6
24
2.66
1.34
10.8
16.4
132.67
131.79
g/l
—
6
24
21
136
1.84
1.32
4.3
3.4
—
—
—
0
0
5
18
2.93
1.31
1.4
1.1
—
—
—
0
0
11
57
2.14
1.26
7.4
3.2
2.35
2.42
g/l
0.13
11
50
5
19
2.77
1.24
4.4
2.4
—
—
—
0
0
18
114
1.83
1.20
10.4
3.3
—
7.39
—
0
23
13
74
1.97
1.18
5.3
5.1
306.38
8952.36
umol/l
0.78
13
64
5
21
2.50
1.11
5.2
26.9
24.38
24.28
mmol/l
—
5
21
54
482
2.20
1.09
25.2
12.0
24.81
22.67
mg/l
0.23
45
349
18
118
1.75
1.07
1.9
2.4
46.33
64.69
u/l
0.82
18
109
20
136
1.71
1.05
2.8
1.6
88.58
98.16
pmol/l
0.43
12
61
26
190
1.65
1.04
7.2
4.8
19.57
60.89
e6/l
1.10
20
129
9
50
1.94
1.02
3.6
2.6
285.67
359.29
nmol/l
—
9
45
17
111
1.74
1.02
7.9
3.5
—
—
—
0
0
32
248
1.62
1.01
11.7
9.0
—
—
—
0
0
37
301
1.60
0.93
9.3
4.5
—
29.40
—
0
5
18
123
1.66
0.91
2.1
1.9
—
—
—
0
0
39
323
1.59
0.89
8.3
4.6
—
—
—
0
0
12
74
1.78
0.86
12.8
8.4
23.96
24.19
mmol/l
0.19
12
74
33
265
1.55
0.85
9.2
7.8
6.75
6.12
mmol/l
0.37
33
233
7
38
1.95
0.77
2.6
1.4
—
—
—
0
0
8
129
0.56
0.74
1.5
1.9
—
—
—
0
0
7
41
1.80
0.73
3.3
1.1
3232.86
62.11
u/ml
—
7
33
7
42
1.75
0.71
16.6
11.3
104.71
105.12
mmol/l
—
7
42
5
27
1.93
0.70
1.0
1.0
—
—
—
0
0
5
27
1.93
0.70
9.0
8.1
106.00
127.59
g/l
—
5
27
13
88
1.61
0.67
13.8
11.5
—
7.42
—
0
6
5
29
1.79
0.65
2.2
2.4
—
—
—
0
0
8
124
0.59
0.63
4.6
3.6
—
—
—
0
0
19
144
1.47
0.61
2.4
1.8
—
—
—
0
0
49
444
1.57
0.60
31.9
15.2
3.99
3.96
mmol/l
0.30
49
423
49
446
1.54
0.56
31.7
15.3
139.73
139.38
mmol/l
0.77
49
427
13
92
1.53
0.56
25.3
12.5
1.16
1.33
mmol/l
1.39
13
87
20
156
1.42
0.55
2.0
2.1
—
—
—
0
0
12
87
1.47
0.46
9.4
4.0
—
1.01
—
0
18
5
33
1.56
0.42
9.2
14.3
2.98
0.48
mmol/l
—
5
24
0
16
0.00
0.41
0.0
2.0
—
—
—
0
0
10
72
1.47
0.40
15.1
10.7
—
—
—
0
0
9
70
1.34
0.39
2.7
1.5
—
—
—
0
0
6
44
1.40
0.35
1.2
1.2
—
—
—
0
0
7
53
1.36
0.32
2.1
2.0
—
—
—
0
0
8
62
1.33
0.29
1.0
1.1
—
—
—
0
0
13
107
1.27
0.24
4.8
3.7
46.34
99.84
ng/l
—
7
67
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
6
48
1.28
0.21
1.5
1.2
—
—
—
0
0
6
48
1.28
0.21
1.3
1.4
—
617.78
—
0
9
11
91
1.26
0.19
1.3
1.8
1.36
1.45
mmol/l
0.09
11
78
5
65
0.75
0.18
2.4
6.2
3.38
2.31
ug/l
—
5
57
13
111
1.22
0.17
10.1
4.1
0.00
0.02
estimate
—
5
43
24
218
1.17
0.17
9.1
5.6
0.00
0.00
estimate
—
5
46
9
81
1.13
0.16
4.8
3.9
—
—
—
0
0
24
220
1.15
0.15
7.6
3.8
0.00
0.00
estimate
—
5
49
17
189
0.86
0.14
8.4
3.6
—
6.50
—
0
17
9
108
0.80
0.14
2.0
1.9
—
—
—
0
0
51
491
1.26
0.14
23.7
9.7
—
—
—
0
0
10
116
0.83
0.13
1.5
1.7
—
—
—
0
0
24
222
1.14
0.12
7.5
3.9
0.00
0.00
estimate
—
5
48
6
53
1.15
0.09
1.2
1.2
—
42.93
—
0
11
18
166
1.12
0.09
1.7
1.7
—
—
—
0
0
37
358
1.09
0.06
4.6
3.7
4.32
4.45
mmol/l
0.40
37
328
37
358
1.09
0.06
4.9
4.0
2.44
2.61
mmol/l
0.59
37
324
47
461
1.09
0.04
26.5
12.8
73.83
63.89
umol/l
0.34
47
461
33
321
1.06
0.03
5.6
4.8
37.04
37.80
mmol/mol
0.16
33
299
22
225
0.96
0.00
4.3
3.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.4
—
10.91
—
0
8
0
5
0.00
-0.00
0.0
4.4
—
106.20
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.5
—
6.28
—
0
8
0
8
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
1.63
—
0
8
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.4
—
3.78
—
0
5
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.9
—
11.71
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
165.60
—
0
5
0
7
0.00
-0.00
0.0
2.9
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.4
—
4.79
—
0
8
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.8
—
53.33
—
0
9
0
9
0.00
-0.00
0.0
5.3
—
3.00
—
0
9
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
3.3
—
1.49
—
0
9
0
9
0.00
-0.00
0.0
1.8
—
3.84
—
0
9

Mortality – FinRegistry

Association

Association between endpoint L12_DIAPER and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_DIAPER.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: L12_DIAPER – Diaper [napkin] dermatitis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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