Calcification and ossification of muscle

M13_CALCIOSSIMUSCLE

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M61 Hospital discharge: ICD-9 — 7281B\|7281X Hospital discharge: excluded ICD-10 — M61.0, M61.1 Cause of death: ICD-10 — M61 Cause of death: ICD-9 — 7281B\|7281X Cause of death: excluded ICD-10 — M61.0, M61.1 2 out of 7 registries used, show all original rules.	92
4. Check minimum number of events None	92
5. Include endpoints None	92
6. Filter based on genotype QC (FinnGen only)	90

Control definitions (FinnGen only)

Control exclude: M13_SOFTTISSUE

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: M60-M63
Name in latin: Calcificatio et ossificatio musculi

NAME	M13_CALCIOSSIMUSCLE
CONTROL_EXCLUDE	M13_SOFTTISSUE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M61
HD_ICD_9	7281B\|7281X
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL	M61[0-1]
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M61
COD_ICD_9	7281B\|7281X
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL	M61[0-1]
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Calcification and ossification of muscle based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	594	264	323
Only index persons	508	233	275
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	53.41	53.62	53.09
Only index persons	52.03	52.67	51.49

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	90	42	48
Unadjusted period prevalence (%)	0.02	0.01	0.02
Median age at first event (years)	52.55	46.97	57.44

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
92: Matched controls
920

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M61.9

ICD-10 Finland

Calcification and ossification of muscle, unspecified

+∞

40.7

M61.4

ICD-10 Finland

Other calcification of muscle

+∞

22.9

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

6.9

13.7

N03AX16

ATC

[U] pregabalin

5.0

12.1

105

M61.3

ICD-10 Finland

Calcification and ossification of muscles associated with burns

+∞

10.6

N02AX02

ATC

tramadol; systemic, rectal

4.0

9.9

240

M61.5

ICD-10 Finland

Other ossification of muscle

+∞

9.5

M61.2

ICD-10 Finland

Paralytic calcification and ossification of muscle

+∞

9.5

M75.4

ICD-10 Finland

Impingement syndrome of shoulder

55.5

8.9

M75.1

ICD-10 Finland

Rotator cuff syndrome

4.4

8.6

M79.6

ICD-10 Finland

Pain in limb

3.5

8.0

170

N06AX21

ATC

duloxetine; oral

5.1

7.3

J01MA02

ATC

ciprofloxacin; systemic

3.2

7.1

218

M16.1

ICD-10 Finland

Other primary coxarthrosis

4.5

6.9

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

3.2

6.7

193

N02BF02

ATC

pregabalin; oral

12.3

6.5

7281X

ICD-9 Finland

Disorders of muscle, ligament and fascia, Muscular calcification and ossification[CALCIFICATIO ET OSSIFICATIO MUSCULI ALIA]

+∞

6.3

T84.0

ICD-10 Finland

Mechanical complication of internal joint prosthesis

13.8

6.2

R4120

NOMESCO Finland

Occupational therapy

8.2

6.2

Z3226

NOMESCO Finland

Physiotherapist

3.7

6.2

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3020779) Urea [Moles/volume] in Serum or Plasma

4.73

7.63

10.1

6.1

9.45

10.72

mmol/l

0.15

(3014007) Fractional oxyhemoglobin in Arterial blood

4.76

6.39

11.8

9.3

95.18

92.51

1.15

(40760892) CBC W Ordered Manual Differential panel - Blood

315

2.85

5.66

6.1

5.4

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

312

2.77

5.38

3.7

2.5

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

105

3.06

5.02

1.7

1.8

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

5.13

4.80

10.0

9.5

—

(3005322) IgE [Units/volume] in Serum or Plasma

5.04

4.45

1.5

1.4

268.15

152.39

u/ml

0.24

(3023368) Bacteria identified in Blood by Culture

185

2.55

4.34

6.1

4.4

—

(3007853) Bacteria identified in Skin by Aerobe culture

3.13

4.33

3.5

1.4

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

3.02

4.25

9.8

5.1

1.11

1.07

mmol/l

0.20

(3042936) Bacteria identified in Isolate by Culture

2.89

4.22

2.5

1.9

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

144

2.61

4.13

2.1

1.7

1.31

1.57

mg/l

0.24

113

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

3.25

4.05

2.5

2.1

2.29

8.66

ug/l

1.60

(3022217) INR in Platelet poor plasma by Coagulation assay

328

2.35

3.89

14.5

12.9

1.24

1.21

inr

—

104

(3019060) Gas panel - Arterial blood

3.94

3.81

5.1

3.4

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

176

2.36

3.58

4.2

2.3

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

10.57

3.55

1.2

—

(3052851) Hemolysis interference index of Serum or Plasma

4.96

3.55

2.0

3.3

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

267

2.24

3.51

3.6

3.8

21.58

46.65

ng/l

0.99

184

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

7.46

3.43

1.0

1.9

—

(3026008) Bacteria identified in Urine by Culture

195

2.28

3.41

4.5

2.7

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

127

2.46

3.39

4.0

3.1

35.80

207.73

ng/l

1.06

103

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

150

2.36

3.34

2.3

1.8

2.22

3.15

mg/l

2.24

128

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

5.36

3.12

2.0

2.1

—

(3026493) Urate [Moles/volume] in Serum or Plasma

170

2.24

3.09

1.9

2.5

350.73

9631.51

umol/l

1.31

141

(3037522) Nuclear Ab [Titer] in Serum

2.75

3.09

1.6

1.3

337.14

408.57

titre

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

2.59

3.02

14.2

6.5

104.53

105.27

mmol/l

0.34

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

4.02

2.98

2.1

2.0

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.67

2.93

1.4

1.8

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

7.04

2.91

1.2

1.7

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

267

2.05

2.84

2.1

1.9

87.89

92.13

pmol/l

0.30

141

(3004588) Protein electrophoresis panel - Serum or Plasma

2.82

2.77

1.6

2.2

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

3.21

2.74

1.7

1.4

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

2.77

2.68

1.5

1.9

0.21

0.22

g/l

0.13

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

5.75

2.58

1.5

1.4

—

(40761535) Cells panel - Urine sediment

2.92

2.56

4.8

3.0

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.52

2.51

1.4

1.8

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

3.58

2.47

1.4

1.0

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

5.26

2.44

1.7

1.2

—

(3000991) Gas panel - Venous blood

2.62

2.43

14.8

6.5

—

(40768806) Pleura Pathology biopsy report

6.53

2.40

1.4

2.4

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

2.33

2.36

1.3

1.2

1.23

6.04

u/ml

—

(3020891) Body temperature

3.71

2.33

9.0

4.4

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

4.12

2.30

2.7

1.2

0.23

0.25

g/l

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

5.80

2.24

1.4

1.1

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

3.55

2.24

1.9

1.8

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

3.90

2.20

1.6

1.1

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

3.90

2.20

1.9

1.6

—

(3005895) Myoglobin [Mass/volume] in Serum or Plasma

3.90

2.20

3.9

2.6

295.43

272.26

ug/l

—

(3007164) IgA [Mass/volume] in Serum or Plasma

120

2.10

2.17

1.2

1.5

2.13

2.81

g/l

0.77

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

4.20

2.07

1.8

1.5

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

115

2.07

2.04

3.0

2.3

2.01

1.34

e6/l

0.29

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

2.91

1.99

1.9

2.2

—

(3037467) Urinalysis macro (dipstick) panel - Urine

466

1.83

1.98

6.3

3.5

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.82

1.92

2.0

1.5

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

3.36

1.92

1.3

1.5

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

3.03

1.91

7.2

3.3

22.51

24.02

mmol/l

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

4.34

1.85

1.0

1.3

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

2.06

1.82

1.4

1.2

40.70

64.61

iu/ml

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

2.82

1.77

1.0

1.1

—

(3021589) Normoblasts [#/volume] in Blood

292

1.73

1.76

9.0

11.1

0.00

0.01

e9/l

0.60

240

(3044640) Blood type and Crossmatch panel - Blood

230

1.76

1.74

4.8

2.3

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

2.10

1.72

4.9

3.9

235.31

258.96

u/l

0.27

(4200892) Spirometry reversibility

2.41

1.71

1.4

1.3

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

751

2.36

1.69

30.1

14.8

4.03

3.99

mmol/l

0.58

728

(3003327) Ova and parasites identified in Stool by Light microscopy

3.30

1.69

2.7

1.4

—

(3028026) IgM [Mass/volume] in Serum or Plasma

2.55

1.68

1.4

1.5

0.97

1.81

g/l

—

(3005719) IgG [Mass/volume] in Serum or Plasma

2.43

1.61

3.3

2.5

10.29

10.27

g/l

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

423

1.67

1.58

8.7

4.2

6.65

6.77

mmol/l

0.22

391

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

3.46

1.54

1.2

1.5

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

3.46

1.54

1.2

1.5

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

246

1.68

1.54

4.7

2.6

—

(3013512) EKG study

213

1.69

1.48

3.6

3.8

—

(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence

2.84

1.46

1.5

1.3

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.96

1.41

3.9

6.0

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

441

1.61

1.40

2.5

3.0

—

(3045414) Leukocytes [Presence] in Urine

3.05

1.37

2.0

1.5

—

(36304419) Bacteria [Presence] in Urine

182

1.68

1.37

4.2

2.5

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

778

2.21

1.35

29.0

15.2

84.00

79.43

umol/l

0.25

778

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

108

1.83

1.34

3.2

2.5

2.31

2.64

e6/l

0.08

(3001122) Ferritin [Mass/volume] in Serum or Plasma

300

1.59

1.33

3.9

2.5

328.90

127.29

ug/l

1.12

272

(3022145) Colonoscopy Study observation

2.04

1.30

1.2

1.3

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

714

1.92

1.29

27.2

12.9

28.65

24.71

mg/l

0.41

566

(40758558) Short blood count panel - Blood

168

1.67

1.28

4.5

7.1

—

(3002385) Erythrocyte distribution width [Ratio]

619

1.64

1.17

24.9

16.3

15.64

15.04

0.31

612

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

2.58

1.16

1.2

1.6

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

746

1.91

1.11

30.8

14.9

139.26

139.74

mmol/l

0.91

725

(46235355) HIV 1 and 2 tests - Meaningful Use set

124

1.67

1.07

1.8

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.14

1.05

1.3

1.7

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

2.34

1.04

1.2

1.6

—

(3019309) Folate [Moles/volume] in Red Blood Cells

135

1.62

1.00

1.8

1.6

824.71

1182.68

nmol/l

1.26

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

2.30

0.95

4.7

2.5

0.53

0.78

—

(3019225) pH of Specimen

1.85

0.95

11.1

6.3

—

(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum

2.22

0.93

1.8

2.7

—

1.23

—

(3034860) Kappa light chains.free [Mass/volume] in Serum

2.22

0.93

1.8

2.8

39.88

78.85

mg/l

—

(3047169) Lambda light chains.free [Mass/volume] in Serum or Plasma

2.22

0.93

1.8

2.8

23.20

29.40

mg/l

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

2.14

0.91

6.7

2.4

21.87

23.54

mmol/l

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.14

0.91

4.7

2.6

1.22

1.32

—

(3002582) Erythrocytes [#/volume] in Urine

219

1.47

0.89

4.4

2.6

122.28

376.80

e6/l

0.37

165

(3009508) Creatinine [Moles/volume] in Urine

211

1.47

0.86

3.8

2.9

6.99

7.87

mmol/l

0.56

178

(3011397) Hemoglobin [Presence] in Urine by Test strip

141

1.53

0.84

4.1

3.0

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.77

0.83

1.3

1.5

—

(3000492) Spirometry study

1.76

0.83

2.2

1.5

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

789

1.74

0.81

13.4

9.4

26.18

26.42

u/l

0.06

759

(3023421) Hepatitis B virus surface Ab [Units/volume] in Serum

0.00

0.80

0.0

1.3

—

200.73

—

(3017446) Testosterone [Moles/volume] in Serum or Plasma

1.70

0.75

2.2

2.3

14.19

13.29

nmol/l

0.08

(36660697) Celiac disease serology panel - Serum

1.76

0.72

1.0

1.2

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

113

1.50

0.67

1.2

1.5

—

(3018095) Leukocytes [#/volume] in Urine

249

1.37

0.66

5.1

2.9

367.62

76.09

e6/l

0.47

177

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

1.76

0.65

7.8

4.7

24.36

25.39

mmol/l

—

(3008898) HLA-B27 [Presence]

1.76

0.65

1.2

1.1

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

1.69

0.64

5.5

3.8

5.04

5.22

kpa

—

(40768804) Tissue Pathology biopsy report

279

1.35

0.63

2.3

2.1

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

1.57

0.63

1.2

4.8

1.92

101.69

ug/l

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.51

0.61

1.6

1.5

—

(3002256) Pathology report gross observation

1.52

0.59

1.4

1.3

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.59

0.0

1.3

—

(3015736) pH of Urine

273

1.33

0.58

3.8

2.8

—

5.69

—

(3041096) Erythrocytes [Presence] in Urine by Automated

200

0.70

0.55

3.1

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.62

0.55

1.5

1.3

—

(40761511) CBC panel - Blood by Automated count

765

1.49

0.54

21.8

13.0

—

(3025941) Bacteria identified in Stool by Culture

1.58

0.54

1.7

1.2

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.43

0.52

2.0

4.0

—

(3003694) ABO and Rh group [Type] in Blood

192

1.34

0.52

1.3

—

(3044889) 12 lead EKG panel

504

1.28

0.50

4.7

3.7

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.47

0.44

1.4

1.6

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.41

0.0

1.3

—

(3012501) Base excess in Blood by calculation

0.00

0.41

0.0

3.2

—

2.54

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.41

0.0

3.2

—

8.56

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.41

0.0

3.2

—

4.79

—

(3022313) Gas panel - Capillary blood

1.50

0.41

7.8

4.2

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

274

0.79

0.40

4.6

3.4

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.41

0.38

1.5

—

(40768797) Stomach Pathology biopsy report

1.38

0.38

1.4

1.3

—

(3000963) Hemoglobin [Mass/volume] in Blood

823

1.43

0.33

36.4

19.3

132.55

136.44

g/l

1.37

812

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.69

0.33

1.3

1.4

—

(3009542) Hematocrit [Volume Fraction] of Blood

822

1.45

0.33

37.7

19.3

39.76

40.52

0.49

773

(3035941) MCH [Entitic mass]

822

1.45

0.33

36.1

19.1

30.53

30.41

0.29

810

(3024731) MCV [Entitic volume]

822

1.45

0.33

36.1

19.2

91.71

91.18

0.57

810

(3026361) Erythrocytes [#/volume] in Blood

822

1.45

0.33

37.0

19.2

4.39

4.52

e12/l

1.46

797

(3010813) Leukocytes [#/volume] in Blood

821

1.46

0.32

37.0

19.3

6.94

6.65

e9/l

0.63

796

(3007461) Platelets [#/volume] in Blood

820

1.48

0.32

36.9

19.2

248.64

244.96

e9/l

0.21

798

(3035350) Ketones [Presence] in Urine by Test strip

332

1.19

0.30

3.8

3.2

0.00

estimate

—

(1761868) Lipid panel - Serum or Plasma

285

0.83

0.28

2.1

2.8

—

(21494755) Public health laboratory ask at order entry panel

0.71

0.25

1.3

1.4

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

692

1.19

0.22

24.3

12.8

86.78

80.97

ml/min/173m2

1.21

558

(3012516) Albumin [Mass/volume] in Urine

203

1.18

0.22

4.1

3.1

338.06

378.33

mg/l

—

136

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.20

0.22

4.0

5.2

25.00

24.83

mmol/l

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.9

—

15.89

—

(3007566) Smooth muscle Ab [Titer] in Serum

0.00

0.21

0.0

1.1

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.21

0.0

1.0

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.21

0.0

1.7

—

(3028271) Lactate [Moles/volume] in Capillary blood

0.00

0.21

0.0

2.8

—

1.42

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.2

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.21

0.0

1.2

—

(3034770) Mitochondria Ab [Titer] in Serum

0.00

0.21

0.0

1.2

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

162

0.84

0.18

2.9

3.0

0.49

0.78

ug/l

—

108

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.14

0.18

1.9

1.7

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

102

1.20

0.16

5.1

2.1

2.03

2.36

g/l

1.43

(3000494) Fungus identified in Specimen by Culture

1.17

0.10

1.6

1.4

—

(3029937) Albumin [Presence] in Urine by Test strip

185

0.90

0.09

4.9

3.5

0.00

estimate

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

1.14

0.09

1.3

1.4

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

225

0.91

0.08

3.1

4.5

18.15

19.92

—

111

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.81

0.08

1.0

1.2

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.03

0.08

1.9

1.8

—

(4035726) Immunohistochemistry procedure

1.09

0.08

1.8

1.4

—

(3020682) Albumin/Creatinine [Ratio] in Urine

217

1.08

0.07

4.7

3.6

71.26

8.07

mg/mmol

—

137

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

-0.00

0.0

1.3

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

-0.00

0.0

1.0

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

-0.00

0.0

1.4

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.7

—

(3045716) Anion gap in Serum or Plasma

0.00

-0.00

0.0

3.6

—

10.80

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

6.14

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.97

-0.00

1.3

1.6

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

0.00

-0.00

0.0

1.2

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.7

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

-0.00

0.0

1.2

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

-0.00

0.0

1.0

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

-0.00

0.0

1.0

—

13.40

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

337.40

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

14.3

—

821.13

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

-0.00

0.0

1.4

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

3.5

—

3.51

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3017569) Oxygen content in Arterial blood

0.00

-0.00

0.0

11.3

—

(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

29.80

—

(3005033) Fetal Nuchal fold Thickness US

0.00

-0.00

0.0

1.4

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

27.9

—

1612.13

—

(40760848) Basement membrane zone BP180 Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.1

—

(3015183) Erythrocyte sedimentation rate

0.00

-0.00

0.0

1.6

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

-0.00

0.0

1.0

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

-0.00

0.0

1.0

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.0

—

(3011648) Oxygen content in Venous blood

0.00

-0.00

0.0

1.0

—

10.66

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

-0.00

0.0

2.4

—

90.51

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

-0.00

0.0

15.2

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

-0.00

0.0

1.2

—

(40768441) Liver Pathology biopsy report

0.00

-0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint M13_CALCIOSSIMUSCLE and mortality.

Females

No data

Males

Parameter	HR [95% CI]	p-value
M13_CALCIOSSIMUSCLE	1.461 [1.02, 2.09]	0.037
Birth year	0.993 [0.98, 1.0]	0.108

During the follow-up period (1.1.1998 — 31.12.2019), 64 out of 217 males with M13_CALCIOSSIMUSCLE died.

Mortality risk

Mortality risk for people of age

years, who have M13_CALCIOSSIMUSCLE.

N-year risk	Females	Males
1	No data	0.288%
5	No data	2.012%
10	No data	5.072%
15	No data	9.751%
20	No data	16.361%

Relationships between endpoints

↥

Index endpoint: M13_CALCIOSSIMUSCLE – Calcification and ossification of muscle

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Calcification and ossification of muscle

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints