Endometriosis in cutaneous scar

N14_ENDOMETRIOSIS_SKIN_SCAR

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

only females

293373

2. Check conditions

None

293373

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 N80.6
  • Hospital discharge: ICD-9 6176
  • Cause of death: ICD-10 N80.6
  • Cause of death: ICD-9 6176

2 out of 7 registries used, show all original rules.

121

4. Check minimum number of events

None

121

5. Include endpoints

None

121

6. Filter based on genotype QC (FinnGen only)

121

Control definitions (FinnGen only)

Control exclude
N14_FEMALEGENNONINF

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
N80
Name in latin
Endometriosis cicatricis cutaneae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 700 700 -
Only index persons 683 683 -
Unadjusted period prevalence (%)
Whole population 0.02 0.02 -
Only index persons 0.03 0.03 -
Median age at first event (years)
Whole population - 36.97 -
Only index persons - 36.92 -

-FinnGen-

Key figures

All Female Male
Number of individuals 121 121 -
Unadjusted period prevalence (%) 0.04 0.04 -
Median age at first event (years) 36.40 36.40 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
110
Matched controls
1100
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N80.6
ICD-10 Finland
Endometriosis in cutaneous scar
+∞
127.0
96
*
N80.3
ICD-10 Finland
Endometriosis of pelvic peritoneum
+∞
24.9
23
*
N80.9
ICD-10 Finland
Endometriosis, unspecified
+∞
21.6
20
*
JAA10
NOMESCO Finland
Excision of lesion of abdominal wall
+∞
18.2
17
*
N80.0
ICD-10 Finland
Endometriosis of uterus
212.7
18.1
18
*
N81.6
ICD-10 Finland
Rectocele
198.7
17.0
17
*
6176A
ICD-9 Finland
Endometriosis in scar of skin
+∞
16.0
15
*
N80.1
ICD-10 Finland
Endometriosis of ovary
+∞
16.0
15
*
N97.9
ICD-10 Finland
Female infertility, unspecified
92.8
15.0
16
*
MCA10
NOMESCO Finland
Lower uterine segment caesarean section
5.8
14.5
49
133
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
5.1
14.1
58
196
N80.89
ICD-10 Finland
Endometriosis with other specified or multiple localization
+∞
13.8
13
*
LEF03
NOMESCO Finland
Posterior colporrpahy with sutures for primary rectocele
+∞
13.8
13
*
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
12.1
13.6
25
26
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
7.3
12.6
32
58
N83.2
ICD-10 Finland
Other and unspecified ovarian cysts
22.0
12.0
17
9
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
12.7
11.9
21
20
TLC00
NOMESCO Finland
Insertion of intrauterine device
11.1
11.7
22
24
LAC01
NOMESCO Finland
Laparoscopic excision of ovarian cyst
66.6
10.8
12
*
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
4.5
10.7
45
146
N92.6
ICD-10 Finland
Irregular menstruation, unspecified
18.4
10.7
16
10
O34.2
ICD-10 Finland
Maternal care due to uterine scar from previous surgery
5.8
10.6
32
72
JAH01
NOMESCO Finland
Laparoscopy
14.1
10.3
17
14
N81.1
ICD-10 Finland
Cystocele
60.4
9.8
11
*
O82.10
ICD-10 Finland
Delivery by emergency caesarean section
5.7
9.6
29
65
N80.4
ICD-10 Finland
Endometriosis of rectovaginal septum and vagina
+∞
9.5
9
*
JAL21
NOMESCO Finland
Laparoscopic excision or destruction of lesion of peritoneum
+∞
9.5
9
*
N92.0
ICD-10 Finland
Excessive and frequent menstruation with regular cycle
8.2
9.1
20
29
N97.8
ICD-10 Finland
Female infertility of other origin
97.1
8.5
9
*
XW3AT
NOMESCO Finland
Biopsy of other superficial organ with ultrasound guidance
+∞
8.4
8
*
D25.9
ICD-10 Finland
Leiomyoma of uterus, unspecified
8.4
8.4
18
25
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
3.4
8.0
52
230
LCA06
NOMESCO Finland
Biopsy of endometrium
9.1
7.9
16
20
JAP01
NOMESCO Finland
Laparoscopic freeing of adhesions in the peritoneal cavity
48.5
7.8
9
*
JN2CG
NOMESCO Finland
Extensive MRI examination of lower part of abdoment with high intensity magnet
48.5
7.8
9
*
N02BE01
ATC
paracetamol; systemic, rectal
5.0
7.8
100
731
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
5.4
7.7
23
51
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
5.3
7.5
23
52
N95.1
ICD-10 Finland
Menopausal and female climacteric states
+∞
7.4
7
*
WX402
NOMESCO Finland
General anaesthesia
4.5
7.2
26
70
G03GA01
ATC
chorionic gonadotrophin; parenteral
15.1
7.1
11
8
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
7.3
6.9
16
25
G03GA06
ATC
follitropin beta; parenteral
18.1
6.9
10
6
ULC02
NOMESCO Finland
Hysteroscopy
18.1
6.9
10
6
N81.2
ICD-10 Finland
Incomplete uterovaginal prolapse
42.7
6.8
8
*
N84.0
ICD-10 Finland
Polyp of corpus uteri
42.7
6.8
8
*
Z35.0
ICD-10 Finland
Supervision of pregnancy with history of infertility
24.2
6.8
9
*
O82.0
ICD-10 Finland
Delivery by elective caesarean section
4.9
6.6
21
50
N80
ICD-10 Finland
Endometriosis
73.9
6.5
7
*
N80.5
ICD-10 Finland
Endometriosis of intestine
+∞
6.3
6
*
LAA10
NOMESCO Finland
Percutaneous or transvaginal puncture and recovery of oocyte
+∞
6.3
6
*
LEF00
NOMESCO Finland
Anterior colporraphy with sutures for primary cystocele
+∞
6.3
6
*
R22.2
ICD-10 Finland
Localized swelling, mass and lump, trunk
7.5
6.3
14
21
LC2HE
NOMESCO Finland
Hystero-salpingography with ultrasound
13.6
6.2
10
8
N92.1
ICD-10 Finland
Excessive and frequent menstruation with irregular cycle
13.6
6.2
10
8
B02AA02
ATC
tranexamic acid; systemic
4.0
6.1
24
71

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
33
82
5.16
13.13
1.3
1.2
—
—
—
0
0
69
358
3.16
8.87
2.0
1.6
—
—
—
0
0
10
17
6.32
5.72
1.9
1.3
40.3
84.9
pmol/l
—
10
17
16
46
3.86
5.09
2.8
3.7
28.6
69.8
u/ml
0.41
16
46
46
246
2.40
4.90
2.2
1.8
—
—
—
0
0
21
83
2.85
4.06
1.4
1.3
—
—
—
0
0
38
213
2.14
3.46
1.9
1.7
0.7
0.8
mg/l
0.06
29
159
41
237
2.10
3.45
6.2
4.7
1.0
1.1
inr
0.59
11
71
114
999
3.44
3.36
12.9
9.0
20.0
19.3
mg/l
0.09
98
715
39
231
2.02
3.03
2.0
2.2
—
—
—
0
0
19
84
2.50
2.95
1.3
1.4
48.5
25.0
iu/l
0.93
14
74
32
178
2.08
2.93
2.8
2.4
—
—
—
0
0
22
105
2.34
2.91
2.5
2.5
13.6
14.8
umol/l
0.33
22
98
26
135
2.18
2.83
3.4
2.2
6.9
7.8
e6/l
0.16
26
117
13
49
2.85
2.72
1.4
1.2
—
—
—
0
0
82
639
1.88
2.64
5.0
3.5
—
—
—
0
0
5
12
4.30
1.84
1.4
1.1
—
—
—
0
0
73
587
1.61
1.77
2.7
2.9
—
—
—
0
0
54
407
1.59
1.69
13.1
6.4
0.0
0.0
e9/l
0.62
44
325
35
239
1.65
1.62
5.0
2.3
—
—
—
0
0
48
355
1.58
1.62
4.1
2.7
—
—
—
0
0
57
439
1.56
1.61
6.9
3.9
0.0
0.0
estimate
0.49
14
77
13
64
2.16
1.61
1.0
1.2
—
—
—
0
0
57
442
1.55
1.55
5.1
2.8
0.0
0.0
estimate
0.00
14
77
41
295
1.59
1.54
2.2
1.8
95.0
93.5
pmol/l
0.08
21
173
7
27
2.69
1.54
4.0
2.2
0.7
0.6
%
—
7
27
37
261
1.60
1.50
1.4
1.2
0.6
1.4
u/ml
0.59
13
77
38
271
1.59
1.47
4.6
2.9
62.1
65.1
e6/l
0.02
32
164
14
74
2.01
1.46
1.6
1.4
—
—
—
0
0
9
40
2.35
1.43
3.8
2.5
4.7
4.4
kpa
—
9
40
16
91
1.87
1.37
1.1
1.3
276.5
90.8
iu/ml
—
7
43
29
198
1.61
1.34
4.1
2.5
—
—
—
0
0
24
157
1.66
1.30
3.5
3.2
—
—
—
0
0
56
446
1.48
1.28
5.2
2.9
0.0
0.0
estimate
0.00
12
77
57
456
1.47
1.27
4.6
3.8
6.5
6.3
mmol/l
0.29
51
405
105
955
1.75
1.27
4.0
3.4
1.5
1.6
mmol/l
0.45
100
912
10
49
2.13
1.26
3.5
4.0
0.6
2.8
mmol/l
—
10
38
5
19
2.70
1.23
1.0
1.2
—
—
—
0
0
33
238
1.53
1.20
1.5
1.2
2.0
2.1
g/l
0.18
26
152
10
50
2.09
1.20
3.5
3.9
—
—
—
0
0
7
30
2.41
1.14
4.0
2.2
0.9
1.4
%
—
7
30
32
232
1.52
1.14
5.4
3.2
0.0
0.0
estimate
0.49
15
76
12
66
1.91
1.13
5.8
2.5
—
—
—
0
0
16
97
1.75
1.13
1.1
1.1
—
—
—
0
0
14
82
1.80
1.10
1.9
1.2
—
—
—
0
0
5
21
2.44
1.10
1.0
1.0
—
—
—
0
0
50
400
1.43
1.08
4.9
5.7
10.7
9.2
umol/l
0.62
44
380
5
22
2.33
1.04
1.8
1.2
261.7
139.7
u/ml
—
5
15
113
1069
1.86
1.01
12.8
8.5
—
—
—
0
0
58
481
1.40
1.01
7.2
5.3
1.8
2.1
e9/l
0.96
50
428
49
395
1.40
1.00
2.7
2.3
—
—
—
0
0
22
152
1.55
0.97
2.4
2.0
—
—
—
0
0
11
63
1.82
0.93
3.2
3.2
—
—
—
0
0
55
464
1.34
0.82
7.4
5.5
0.0
0.0
e9/l
0.19
48
404
15
100
1.57
0.77
1.3
1.7
—
—
—
0
0
15
100
1.57
0.77
1.3
1.2
—
—
—
0
0
30
235
1.37
0.71
3.9
4.4
—
—
—
0
0
54
462
1.30
0.71
7.5
5.4
0.5
0.5
e9/l
0.86
48
405
5
94
0.51
0.70
4.6
1.7
—
—
—
0
0
13
87
1.55
0.66
1.2
1.3
—
—
—
0
0
56
485
1.29
0.66
7.5
6.2
0.2
0.2
e9/l
0.49
51
427
61
535
1.28
0.65
9.5
8.8
3.8
4.0
e9/l
0.43
53
468
5
29
1.75
0.64
1.2
2.1
—
—
—
0
0
5
30
1.69
0.62
1.0
1.2
—
—
—
0
0
98
919
1.35
0.59
3.8
3.0
1.2
1.1
mmol/l
0.09
93
871
11
159
0.66
0.59
1.4
1.3
—
—
—
0
0
6
36
1.70
0.57
1.3
1.3
—
—
—
0
0
9
59
1.57
0.56
1.2
2.4
—
—
—
0
0
6
38
1.61
0.55
1.2
1.3
—
—
—
0
0
11
75
1.51
0.53
2.9
2.2
373.4
386.6
nmol/l
0.12
11
69
93
871
1.29
0.52
16.3
12.0
13.3
13.5
%
0.68
93
858
27
219
1.30
0.51
4.0
3.0
—
—
—
0
0
37
314
1.26
0.49
1.5
1.8
—
—
—
0
0
27
220
1.29
0.49
1.2
1.7
—
—
—
0
0
10
68
1.51
0.48
1.2
1.2
—
—
—
0
0
23
184
1.31
0.48
2.5
2.9
18.8
52.0
mg/l
1.20
18
113
30
251
1.26
0.45
2.0
2.8
9.9
15.8
ng/l
1.54
11
123
31
261
1.25
0.44
8.4
5.9
—
—
—
0
0
25
205
1.28
0.44
3.8
3.3
1.0
1.0
kg/l
—
5
28
36
311
1.22
0.41
1.7
1.6
—
—
—
0
0
5
34
1.49
0.41
2.0
2.4
—
—
—
0
0
9
66
1.39
0.39
1.2
1.2
—
26.8
—
0
6
13
98
1.37
0.39
1.4
1.3
—
—
—
0
0
23
191
1.25
0.37
3.4
3.5
2.7
10.5
mg/mmol
1.42
18
115
6
43
1.42
0.35
1.0
1.0
—
—
—
0
0
7
53
1.34
0.31
5.4
5.7
—
—
—
0
0
19
159
1.23
0.29
1.4
1.5
—
—
—
0
0
14
171
0.79
0.28
1.5
1.3
1.5
9.3
u/ml
—
5
66
10
77
1.33
0.27
2.5
2.1
—
21.4
—
0
7
9
73
1.25
0.26
1.1
1.5
—
—
—
0
0
5
37
1.37
0.24
7.2
4.7
23.0
25.3
mmol/l
—
5
37
5
37
1.37
0.24
4.2
6.7
88.3
94.9
%
—
5
37
5
38
1.33
0.23
4.2
6.6
1.0
0.7
%
—
5
38
5
38
1.33
0.23
4.2
6.6
1.3
1.3
%
—
5
38
5
39
1.29
0.23
1.8
1.7
—
—
—
0
0
29
269
1.10
0.13
1.7
1.7
—
—
—
0
0
5
47
1.07
0.09
1.6
1.2
—
—
—
0
0
12
134
0.88
0.09
2.3
3.3
62.4
203.0
ng/l
—
5
78
6
54
1.12
0.09
1.3
1.4
—
—
—
0
0
5
60
0.83
0.08
1.4
1.2
—
—
—
0
0
97
959
1.06
0.04
14.3
11.2
39.4
39.7
%
0.14
76
787
22
230
0.95
0.04
7.9
7.2
—
—
—
0
0
17
174
0.97
0.00
1.5
1.3
12.4
32.6
iu/ml
—
5
50
13
131
0.99
0.00
1.8
1.6
—
—
—
0
0
23
233
0.98
0.00
2.0
1.6
1.1
1.3
mmol/l
1.38
23
218
0
9
0.00
0.00
0.0
6.1
—
0.6
—
0
9
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
5
56
0.89
0.00
1.4
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
12.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.9
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
6.3
—
0
6
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
7.0
—
—
—
0
0
0
6
0.00
0.00
0.0
4.0
—
11.2
—
0
6
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
5
52
0.96
0.00
1.4
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.1
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint N14_ENDOMETRIOSIS_SKIN_SCAR and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have N14_ENDOMETRIOSIS_SKIN_SCAR.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: N14_ENDOMETRIOSIS_SKIN_SCAR – Endometriosis in cutaneous scar

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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