Birth injury to skeleton

P16_BIRTHINJY_SKELETON

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — P13 Cause of death: ICD-10 — P13 2 out of 7 registries used, show all original rules.	44
4. Check minimum number of events None	44
5. Include endpoints None	44
6. Filter based on genotype QC (FinnGen only)	44

Control definitions (FinnGen only)

Control exclude: P16_BIRTH_TRAUMA

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: P1[0-5]
Name in latin: Laesio intranatalis sceleti

NAME	P16_BIRTHINJY_SKELETON
CONTROL_EXCLUDE	P16_BIRTH_TRAUMA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	P13
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	P13
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Birth injury to skeleton based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	3370	1400	1969
Only index persons	1916	787	1129
Unadjusted period prevalence (%)
Whole population	0.05	0.04	0.06
Only index persons	0.04	0.03	0.04
Median age at first event (years)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.02	0.01

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	44	24	20
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	0.04	0.05	0.02

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3013139) Helicobacter pylori Ag [Presence] in Stool

5.33

2.72

1.0

1.1

—

(3003327) Ova and parasites identified in Stool by Light microscopy

4.17

2.25

1.9

1.5

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

2.80

2.10

3.3

2.2

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

4.16

2.01

2.2

2.0

—

(3044640) Blood type and Crossmatch panel - Blood

2.46

1.76

3.6

2.4

—

(3023368) Bacteria identified in Blood by Culture

2.46

1.47

2.9

3.1

—

(3022948) Iron [Moles/volume] in Serum or Plasma

2.67

1.46

3.1

3.7

11.27

14.24

umol/l

—

(3042936) Bacteria identified in Isolate by Culture

2.85

1.42

1.3

2.0

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

2.73

1.35

2.7

4.0

21.78

22.50

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

157

1.97

1.35

3.3

2.5

37.67

37.08

mmol/mol

0.07

145

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

106

1.98

1.27

4.8

3.1

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.28

1.23

1.6

1.9

—

(3000991) Gas panel - Venous blood

2.24

1.22

10.7

13.6

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

2.15

1.20

2.5

3.4

—

(1761868) Lipid panel - Serum or Plasma

2.11

1.15

1.5

2.2

—

(40768797) Stomach Pathology biopsy report

2.55

1.12

1.2

1.6

—

(42870588) Differential panel, method unspecified - Blood

137

1.84

1.11

11.8

7.1

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.96

1.02

2.0

1.5

—

(3015736) pH of Urine

105

1.82

1.00

2.6

3.0

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

116

1.76

0.93

5.3

3.3

64.80

63.59

nmol/l

0.09

106

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

184

1.67

0.85

3.6

2.9

4.37

4.39

mmol/l

0.07

174

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

1.84

0.81

1.2

1.5

98.56

93.06

pmol/l

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.83

0.76

1.8

1.6

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

1.83

0.76

2.1

2.8

45.30

52.61

u/l

—

(3007164) IgA [Mass/volume] in Serum or Plasma

131

1.63

0.76

1.4

1.5

1.35

1.62

g/l

0.68

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

180

1.58

0.71

3.7

2.7

1.31

1.38

mmol/l

0.46

169

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.88

0.68

2.2

1.8

—

(3041096) Erythrocytes [Presence] in Urine by Automated

1.70

0.67

4.0

2.5

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

173

1.54

0.65

2.5

1.8

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

0.62

0.0

1.2

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.62

0.0

1.2

—

(3022096) Basophils/100 leukocytes in Blood

186

1.50

0.58

12.3

6.9

0.57

0.59

0.09

181

(3037467) Urinalysis macro (dipstick) panel - Urine

196

1.49

0.57

6.0

3.6

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.54

0.57

2.1

1.7

—

(3020961) Endomysium IgA Ab [Titer] in Serum

1.67

0.57

1.2

1.3

—

(3020779) Urea [Moles/volume] in Serum or Plasma

1.62

0.55

12.2

10.6

4.45

5.11

mmol/l

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

357

1.81

0.52

4.6

3.7

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

105

1.49

0.49

1.8

1.7

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

1.52

0.49

3.8

2.9

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

181

1.43

0.48

3.7

2.7

2.72

2.66

mmol/l

0.14

168

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

211

1.43

0.47

9.2

5.4

110.97

113.10

ml/min/173m2

0.17

124

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.55

0.46

7.5

11.9

26.12

24.81

mmol/l

—

(40761511) CBC panel - Blood by Automated count

338

1.59

0.46

11.2

7.1

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.69

0.45

2.6

1.4

—

(3006504) Eosinophils/100 leukocytes in Blood

193

1.40

0.44

12.3

6.7

2.77

3.17

0.31

183

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.63

0.44

1.6

2.0

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.63

0.44

1.6

2.0

—

(3044889) 12 lead EKG panel

134

0.67

0.43

3.0

2.3

—

(40768804) Tissue Pathology biopsy report

1.48

0.42

2.2

1.9

—

(3014599) Egg white IgE Ab [Units/volume] in Serum

0.00

0.42

0.0

1.9

—

6.72

—

(3013512) EKG study

1.48

0.41

8.0

2.1

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.44

0.39

1.2

1.1

—

(3002030) Lymphocytes/100 leukocytes in Blood

206

1.36

0.39

12.0

6.5

36.43

35.12

0.27

199

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.48

0.38

1.8

1.7

—

(3019069) Monocytes/100 leukocytes in Blood

197

1.35

0.37

12.4

6.7

9.00

8.47

0.47

190

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.43

0.36

2.4

2.0

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

179

1.33

0.34

3.4

2.6

1.07

1.13

mmol/l

0.25

169

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

1.38

0.33

4.1

1.4

1.20

1.37

—

(3018010) Neutrophils/100 leukocytes in Blood

200

1.31

0.32

12.3

6.5

47.04

49.92

0.83

193

(3001122) Ferritin [Mass/volume] in Serum or Plasma

161

1.32

0.31

4.0

2.9

41.73

47.67

ug/l

0.21

148

(3003694) ABO and Rh group [Type] in Blood

104

1.35

0.31

2.2

1.5

—

(3026008) Bacteria identified in Urine by Culture

1.39

0.29

2.9

2.4

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.40

0.24

2.4

1.5

—

(1616796) Gas panel - Central venous blood

0.00

0.21

0.0

1.5

—

(3009466) Valproate [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

3.6

—

428.70

—

(3002670) Multiple inhalant allergen IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

3.5

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.4

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.26

0.21

1.0

1.1

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.21

0.0

1.3

—

(3020874) Milk IgE Ab [Units/volume] in Serum

0.00

0.20

0.0

1.4

—

0.81

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

116

1.17

0.11

4.4

2.6

—

(3022313) Gas panel - Capillary blood

1.08

0.09

5.7

7.4

—

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

1.06

0.09

5.2

7.1

24.67

24.46

mmol/l

—

(3000764) Benzodiazepines [Presence] in Urine

0.80

0.09

2.4

2.1

—

(3027944) Amphetamines [Presence] in Urine

0.80

0.09

2.4

2.1

—

(3028300) Cannabinoids [Presence] in Urine

0.78

0.09

2.4

2.1

—

(3027008) Opiates [Presence] in Urine

0.78

0.09

2.4

2.1

—

(3021589) Normoblasts [#/volume] in Blood

197

1.13

0.08

17.0

8.2

0.00

e9/l

0.48

154

(46235355) HIV 1 and 2 tests - Meaningful Use set

108

1.15

0.08

3.5

2.1

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

108

1.15

0.08

3.9

2.5

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.14

0.08

3.1

1.7

—

(36304419) Bacteria [Presence] in Urine

0.89

0.07

5.0

3.9

—

(40758558) Short blood count panel - Blood

111

0.87

0.07

21.1

5.9

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

111

1.11

0.04

6.3

4.0

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

245

1.05

0.00

5.2

3.2

14.77

14.31

pmol/l

0.39

211

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.0

1.7

—

(3027231) Wheat IgE Ab [Units/volume] in Serum

0.00

0.0

1.4

—

(3020287) Protein C actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.4

—

123.43

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

0.00

0.0

1.6

—

(3026782) Osmolality of Urine

1.02

0.00

8.0

2.7

514.67

535.88

mosm/kgh2o

—

(3029493) Herpes virus 6 DNA [Presence] in Blood by NAA with probe detection

0.00

0.0

6.6

—

(4306422)

0.00

0.0

1.0

—

(3027450) Sjogrens syndrome-B extractable nuclear Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

0.00

0.0

1.7

—

(3023939) Sjogrens syndrome-A extractable nuclear Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence

0.00

0.0

1.7

—

(3027901) Hemoglobin [Mass/volume] in Arterial cord blood

0.00

0.0

1.0

—

174.80

—

(3023183) Ammonium ion [Moles/volume] in Plasma

0.00

0.0

12.0

—

57.25

—

(3006999) Ribonucleoprotein extractable nuclear Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3012336) Haptoglobin [Mass/volume] in Serum or Plasma

0.00

0.0

4.2

—

0.93

—

(3048469) 10-Hydroxycarbazepine [Moles/volume] in Serum or Plasma

0.00

0.0

2.6

—

49.80

—

(3027135) IgG subclass 1 [Mass/volume] in Serum

0.00

0.0

1.5

—

6.99

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.2

—

(3013336) Amino acids [Identifier] in Serum or Plasma

0.00

0.0

1.4

—

(3021578) Parainfluenza virus 2 Ag [Presence] in Specimen

0.00

0.0

1.0

—

(3008733) Herpes simplex virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.2

—

(3028192) IgG subclass 2 [Mass/volume] in Serum

0.00

0.0

1.5

—

2.41

—

(3026048) Bordetella pertussis IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

344

1.09

0.00

12.3

8.5

12.79

23.06

mg/l

3.15

228

(3009445) Proteinase 3 Ab [Units/volume] in Serum

0.00

0.0

1.7

—

(3005880) Parainfluenza virus 3 Ag [Presence] in Specimen

0.00

0.0

1.0

—

(3024980) IgG subclass 4 [Mass/volume] in Serum

0.00

0.0

1.5

—

0.79

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3022411) Androstenedione [Moles/volume] in Serum or Plasma

0.00

0.0

3.2

—

7.00

—

(3016921) Smith extractable nuclear Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3010464) Parainfluenza virus 1 Ag [Presence] in Specimen

0.00

0.0

1.0

—

(40767663) Brazil Nut recombinant (rBer e) 1 IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(4268621)

0.00

0.0

2.4

—

(3018405) Lactate [Moles/volume] in Arterial blood

0.00

0.0

2.7

—

1.43

—

(3003245) Complement C1 esterase inhibitor [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

0.35

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3024139) IgG subclass 3 [Mass/volume] in Serum

0.00

0.0

1.5

—

0.32

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

0.00

0.0

2.3

—

(3025245) SCL-70 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(4062490)

0.00

0.0

1.5

—

(3020629) Protein S Free Ag actual/normal in Platelet poor plasma by Immunoassay

0.00

0.0

1.0

—

100.80

—

(40760892) CBC W Ordered Manual Differential panel - Blood

0.97

0.00

3.5

3.7

—

(3005011) Chlamydia sp Ab [Titer] in Serum

0.00

0.0

1.4

—

(3023659) Complement C1 esterase inhibitor.functional/Complement C1 esterase inhibitor.total in Serum or Plasma

0.00

0.0

1.0

—

108.20

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

1.01

0.00

2.4

2.0

2.36

2.42

mmol/l

—

(3001684) Respiratory syncytial virus Ag [Presence] in Specimen

0.00

-0.00

0.0

1.1

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.4

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

-0.00

0.0

1.3

—

(3020891) Body temperature

0.00

-0.00

0.0

7.4

—

Mortality – FinRegistry

↥

Association

Association between endpoint P16_BIRTHINJY_SKELETON and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have P16_BIRTHINJY_SKELETON.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: P16_BIRTHINJY_SKELETON – Birth injury to skeleton

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Birth injury to skeleton

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints