Need for immunization against single bacterial diseases

Z21_NEED_IMMUNI_SINGLE_BACTERIAL_DISEA

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — Z23 Cause of death: ICD-10 — Z23 2 out of 7 registries used, show all original rules.	97
4. Check minimum number of events None	97
5. Include endpoints None	97
6. Filter based on genotype QC (FinnGen only)	78

Control definitions (FinnGen only)

Control exclude: Z21_PERSONS_W_POTEN_HEALTH_HAZARDS_RELATED_COMMUNICAB_DISEA

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: Z2

NAME	Z21_NEED_IMMUNI_SINGLE_BACTERIAL_DISEA
CONTROL_EXCLUDE	Z21_PERSONS_W_POTEN_HEALTH_HAZARDS_RELATED_COMMUNICAB_DISEA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	Z23
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	Z23
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Need for immunization against single bacterial diseases based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	78	46	32
Unadjusted period prevalence (%)	0.02	0.02	0.01
Median age at first event (years)	37.92	27.67	52.66

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
97: Matched controls
970

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

Z23.2

ICD-10 Finland

Need for immunization against tuberculosis [BCG]

+∞

45.4

Z23.5

ICD-10 Finland

Need for immunization against tetanus alone

+∞

33.2

Z23.8

ICD-10 Finland

Need for immunization against other single bacterial diseases

+∞

22.8

WW200

NOMESCO Finland

Immunization

20.2

14.2

Z49.0

ICD-10 Finland

Preparatory care for dialysis

98.2

8.6

190

Kela drug reimbursment

Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide

98.2

8.6

A11CC03

ATC

alfacalcidol; systemic

15.0

7.6

123

Kela drug reimbursment

Chronic disorders of vitamin D metabolism

13.5

7.3

Z49.1

ICD-10 Finland

Extracorporeal dialysis

32.7

7.3

N18.9

ICD-10 Finland

Chronic kidney disease, unspecified

15.3

7.1

Z25.1

ICD-10 Finland

Need for immunization against influenza

11.2

6.7

V03AE02

ATC

sevelamer; oral

74.5

6.5

TK800

NOMESCO Finland

Hemodialysis

19.6

6.4

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3018095) Leukocytes [#/volume] in Urine

296

2.98

6.52

8.5

4.6

38.84

31.07

e6/l

0.14

201

(3042602) Urea [Moles/volume] in Serum or Plasma --post dialysis

+∞

6.31

13.3

0.0

3.02

—

mmol/l

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

283

2.81

5.86

6.7

3.8

—

(3002582) Erythrocytes [#/volume] in Urine

257

2.72

5.50

7.5

3.7

12.96

269.79

e6/l

0.50

194

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

158

2.77

5.06

5.7

3.6

3.92

2.32

e6/l

0.31

(3025941) Bacteria identified in Stool by Culture

4.73

4.77

1.3

1.1

—

(3026782) Osmolality of Urine

160

2.61

4.45

4.9

2.5

541.75

539.18

mosm/kgh2o

0.02

131

(3003458) Phosphate [Moles/volume] in Serum or Plasma

179

2.49

4.20

23.9

11.0

1.20

1.37

mmol/l

1.84

171

(40758558) Short blood count panel - Blood

251

2.38

4.15

9.6

8.9

—

(3030467) Casts [#/volume] in Urine by Automated count

246

2.15

3.27

7.0

3.7

0.65

0.41

e6/l

0.19

181

(3005715) Vancomycin [Mass/volume] in Serum or Plasma

6.76

3.24

6.7

9.6

8.80

9.90

mg/l

—

(3000991) Gas panel - Venous blood

152

2.30

3.20

29.6

11.7

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

4.33

3.19

1.6

1.5

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

4.33

3.19

1.6

1.5

—

(3022621) pH of Urine by Test strip

3.87

3.11

3.5

1.6

—

(3006315) Basophils [#/volume] in Blood

463

2.12

3.05

11.8

8.6

0.04

e9/l

0.54

365

(3001604) Monocytes [#/volume] in Blood

464

2.11

3.02

11.8

8.6

0.68

0.60

e9/l

0.63

366

(3017143) Hepatitis C virus Ab [Presence] in Serum

120

2.33

2.93

3.3

1.5

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

165

2.18

2.93

5.5

3.6

0.82

0.79

e6/l

0.03

(40768446) Kidney Pathology biopsy report

7.02

2.91

2.3

2.6

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

4.20

2.85

1.3

1.7

—

(3013115) Eosinophils [#/volume] in Blood

481

2.07

2.81

12.9

9.2

0.21

e9/l

0.02

390

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

108

2.34

2.79

3.0

1.9

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

200

2.08

2.78

3.1

3.4

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

109

2.32

2.73

3.2

2.0

—

(3048689) Calprotectin [Mass/mass] in Stool

140

2.17

2.65

2.4

2.5

61.86

92.21

ug/g

0.61

113

(3000504) BK virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

7.45

2.58

9.6

6.0

—

(3042733) HLA Ab [Presence] in Serum

7.45

2.58

6.8

2.7

—

(40760892) CBC W Ordered Manual Differential panel - Blood

440

1.95

2.56

14.2

9.9

—

(3021601) Nitrite [Presence] in Urine by Test strip

356

1.91

2.51

6.9

4.9

0.00

estimate

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

2.37

2.48

8.2

14.0

102.83

105.25

mmol/l

0.98

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

3.05

2.44

2.2

3.4

—

(3035350) Ketones [Presence] in Urine by Test strip

359

1.89

2.42

4.6

3.2

0.00

0.02

estimate

—

(3009261) Glucose [Presence] in Urine by Test strip

359

1.89

2.42

4.7

3.2

0.00

estimate

—

(4035726) Immunohistochemistry procedure

2.60

2.42

1.5

1.7

—

(3023368) Bacteria identified in Blood by Culture

161

2.04

2.40

7.8

4.1

—

(3022411) Androstenedione [Moles/volume] in Serum or Plasma

6.51

2.40

1.4

2.8

2.72

1.70

nmol/l

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

138

2.09

2.38

3.1

2.0

—

(3007164) IgA [Mass/volume] in Serum or Plasma

270

1.90

2.38

1.9

1.6

1.67

1.71

g/l

0.07

139

(3044640) Blood type and Crossmatch panel - Blood

227

1.93

2.38

4.0

3.0

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

3.43

2.37

2.6

1.7

—

(3021589) Normoblasts [#/volume] in Blood

428

1.88

2.36

14.2

10.4

0.00

0.03

e9/l

0.50

300

(3026008) Bacteria identified in Urine by Culture

180

1.97

2.28

2.8

2.5

—

(3052851) Hemolysis interference index of Serum or Plasma

3.39

2.15

5.1

2.4

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.69

2.09

1.8

2.1

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

177

1.91

2.08

3.0

1.9

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

2.82

2.07

2.4

1.8

—

(36304419) Bacteria [Presence] in Urine

247

1.81

2.00

7.3

3.7

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.39

1.94

2.9

1.6

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

2.81

1.92

1.1

1.2

—

(3045414) Leukocytes [Presence] in Urine

3.35

1.92

2.9

1.3

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

3.02

1.91

2.6

1.9

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

191

1.83

1.87

4.0

2.8

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

3.69

1.87

2.0

2.6

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

508

1.76

1.85

14.6

11.7

3.66

3.84

e9/l

0.25

407

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

4.33

1.84

1.8

1.3

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

3.20

1.83

2.4

1.2

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

143

1.90

1.83

3.1

4.5

1.71

3.14

mg/l

0.45

116

(3027273) Bicarbonate [Moles/volume] in Venous blood

2.81

1.77

34.6

9.5

25.60

23.85

mmol/l

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

3.06

1.76

2.1

1.0

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

3.06

1.76

2.1

1.0

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

707

2.03

1.75

4.2

3.7

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

2.63

1.64

1.3

1.5

—

(3049717) Cytology report of Urine Cyto stain

3.70

1.63

3.4

1.6

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

287

1.67

1.62

1.8

1.7

0.48

4.63

u/ml

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

560

1.72

1.61

4.4

3.4

1.27

1.30

mmol/l

0.13

526

(42529406) Shigella sp [Presence] in Stool by Culture

2.82

1.61

4.1

1.1

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

2.04

1.55

1.1

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.26

1.51

1.4

1.5

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

2.44

1.47

3.9

2.2

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

2.31

1.45

3.8

2.1

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

2.31

1.45

3.9

2.3

—

(3042936) Bacteria identified in Isolate by Culture

121

1.82

1.45

3.4

1.8

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

2.31

1.41

1.2

1.3

—

(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma

2.71

1.39

4.5

4.7

28.50

30.39

umol/l

—

(3020393) Adenovirus Ag [Presence] in Stool

3.04

1.37

1.4

2.4

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

572

1.63

1.37

4.7

3.6

1.37

1.43

mmol/l

0.69

539

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

460

1.58

1.37

5.2

4.2

33.76

37.19

u/l

0.20

447

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

2.02

1.36

6.0

9.0

90.54

88.01

0.14

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

157

1.70

1.34

2.8

1.7

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

2.13

1.33

4.0

8.5

160.36

170.27

0.19

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

101

1.83

1.30

3.9

4.5

0.22

0.21

g/l

0.15

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

2.87

1.30

1.0

1.6

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

2.33

1.27

2.8

1.8

—

(3022217) INR in Platelet poor plasma by Coagulation assay

229

1.59

1.27

5.8

9.4

1.17

1.15

inr

0.04

(3037467) Urinalysis macro (dipstick) panel - Urine

516

1.56

1.25

7.7

3.9

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

2.26

1.25

1.6

2.4

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

119

1.74

1.23

5.2

3.7

323.82

589.37

ng/l

0.38

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

2.72

1.23

1.2

1.6

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

2.20

1.21

1.8

1.2

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

2.39

1.20

1.0

1.1

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

581

1.57

1.20

5.2

3.9

2.70

2.75

mmol/l

0.20

548

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

2.14

1.18

4.1

2.2

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

326

1.51

1.15

3.9

3.0

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

584

1.55

1.14

4.9

3.7

4.46

4.60

mmol/l

0.57

555

(3029937) Albumin [Presence] in Urine by Test strip

164

1.62

1.14

4.7

3.1

0.00

estimate

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

2.03

1.11

4.1

2.3

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

2.03

1.11

4.1

2.3

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.28

1.10

1.3

1.7

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

2.28

1.10

3.1

1.7

—

(3035637) Corticotropin [Mass/volume] in Plasma

2.28

1.10

1.6

2.0

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

2.45

1.10

1.6

1.4

36.80

39.67

nmol/l

—

(40768804) Tissue Pathology biopsy report

228

1.53

1.08

2.3

1.8

—

(3011648) Oxygen content in Venous blood

2.34

1.04

9.8

22.3

9.82

12.02

—

(3034770) Mitochondria Ab [Titer] in Serum

2.34

1.04

1.2

1.4

—

(40763324) Parainfluenza virus 1 RNA [Presence] in Isolate by NAA with probe detection

2.08

1.02

4.6

2.3

—

(40763470) Parainfluenza virus 4 RNA [Presence] in Isolate by NAA with probe detection

2.08

1.02

4.6

2.3

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.92

1.02

2.3

3.3

4.64

5.28

pmol/l

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.02

0.99

67.6

14.4

—

(3007853) Bacteria identified in Skin by Aerobe culture

110

1.66

0.99

2.3

1.6

—

(3028300) Cannabinoids [Presence] in Urine

1.84

0.97

1.2

2.0

—

(3027008) Opiates [Presence] in Urine

1.84

0.97

1.2

1.9

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.80

0.95

2.1

1.3

—

(3000764) Benzodiazepines [Presence] in Urine

1.80

0.95

1.2

1.9

—

(3027944) Amphetamines [Presence] in Urine

1.80

0.95

1.2

1.9

—

(3032773) Endomysium IgG Ab [Titer] in Serum

2.30

0.95

1.0

1.1

—

(21494815) CD4 cells/100 lymphocytes in Specimen

2.22

0.93

3.5

37.63

37.33

—

(3024928) Oxygen saturation in Venous blood

2.22

0.93

8.3

21.3

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

190

1.50

0.92

2.0

1.7

92.51

93.21

pmol/l

0.03

106

(3003327) Ova and parasites identified in Stool by Light microscopy

1.94

0.90

3.4

1.6

—

(3028707) Methadone [Presence] in Urine by Screen method

2.06

0.88

1.2

1.4

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

1.85

0.87

1.1

1.2

—

(36660697) Celiac disease serology panel - Serum

133

1.53

0.81

1.5

1.2

—

(3013707) Erythrocyte sedimentation rate by Westergren method

533

1.39

0.79

6.2

4.1

11.41

8.94

mm/h

0.46

497

(3014148) Varicella zoster virus Ab [Titer] in Serum

2.24

0.77

1.0

1.2

—

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

2.14

0.75

1.8

3.9

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

1.91

0.75

35.6

22.2

133.86

127.37

g/l

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

515

1.37

0.75

25.6

8.7

79.35

92.10

ml/min/173m2

2.02

412

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

574

0.73

0.75

4.0

3.4

5.68

5.60

mmol/l

0.19

533

(3019230) Fractional oxyhemoglobin in Venous blood

2.05

0.74

9.8

19.9

64.20

74.50

—

(3011288) Drugs identified in Urine by Screen method

1.81

0.73

1.1

2.4

—

(3041096) Erythrocytes [Presence] in Urine by Automated

182

1.42

0.70

4.9

2.5

—

(3014007) Fractional oxyhemoglobin in Arterial blood

1.72

0.70

67.9

15.4

93.71

95.13

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.68

0.68

1.7

1.9

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

1.83

0.67

1.0

1.1

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

1.64

0.66

67.9

14.7

1.03

1.20

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

1.64

0.66

1.3

2.0

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

1.64

0.66

67.9

14.7

0.66

0.70

—

(3002256) Pathology report gross observation

1.62

0.65

1.2

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.57

0.63

4.4

1.7

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.70

0.62

1.2

1.8

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

1.70

0.62

1.0

1.2

—

(3000330) Specific gravity of Urine by Test strip

1.70

0.62

3.8

1.8

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.60

0.0

1.4

—

(40761872) Peanut recombinant (rAra h) 2 IgE Ab [Units/volume] in Serum

0.00

0.60

0.0

1.3

—

6.34

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.71

0.58

8.3

18.9

0.53

0.56

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.52

0.56

5.1

1.5

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

255

1.32

0.55

4.6

3.0

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

1.62

0.55

1.0

1.5

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

111

1.42

0.50

1.3

1.2

1.25

6.86

u/ml

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

1.56

0.49

1.4

—

(21494755) Public health laboratory ask at order entry panel

0.57

0.48

1.0

1.5

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

270

1.28

0.47

1.9

1.7

—

(3016879) Cocaine [Presence] in Urine

1.46

0.47

1.3

2.0

—

(3013512) EKG study

131

1.36

0.46

5.5

3.2

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

193

0.74

0.44

1.8

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.48

0.43

1.1

—

(3002523) Influenza virus A Ag [Presence] in Specimen

1.59

0.43

1.0

1.2

—

(3003740) Influenza virus B Ag [Presence] in Specimen

1.59

0.43

1.0

1.2

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

151

1.32

0.43

2.4

3.1

24.63

27.32

ng/l

—

(3032836) C peptide [Moles/volume] in Serum or Plasma --fasting

1.54

0.42

13.0

1.5

0.46

0.62

nmol/l

—

(3033386) Bacteria [Presence] in Cerebral spinal fluid by Light microscopy

0.00

0.41

0.0

1.4

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.41

0.0

1.4

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.40

0.0

4.4

—

(3023520) Reticulocytes [#/volume] in Blood

1.40

0.40

2.7

4.6

38.42

67.34

e9/l

—

(3021387) Prolactin [Units/volume] in Serum or Plasma

1.41

0.39

1.8

1.6

403.60

357.86

mu/l

—

(4200892) Spirometry reversibility

1.42

0.36

2.2

1.5

—

(3027901) Hemoglobin [Mass/volume] in Arterial cord blood

1.42

0.36

1.0

157.00

163.42

g/l

—

(3003694) ABO and Rh group [Type] in Blood

250

1.23

0.35

1.8

1.6

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

111

1.31

0.32

1.4

1.2

10.90

28.08

iu/ml

—

(3022145) Colonoscopy Study observation

1.32

0.29

2.5

1.4

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

1.25

0.28

1.5

1.6

—

(3000494) Fungus identified in Specimen by Culture

1.31

0.27

3.0

1.4

—

(3022313) Gas panel - Capillary blood

172

1.21

0.24

25.9

12.2

—

(3006598) pH of Arterial cord blood

1.30

0.23

1.0

—

(3019225) pH of Specimen

1.26

0.23

16.4

5.3

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.21

0.0

1.0

—

(3016031) Almond IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.3

—

1.39

—

(3028433) Virus identified in Specimen by Culture

0.00

0.21

0.0

1.5

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.21

0.0

1.6

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.6

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.7

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

0.21

0.0

1.4

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

0.21

0.0

1.3

—

(46235689) Lupus anticoagulant aPTT, dRVVT and PT screening panel W Reflex

0.00

0.21

0.0

2.1

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

0.21

0.0

1.3

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.21

0.0

1.5

—

(1761868) Lipid panel - Serum or Plasma

213

1.17

0.21

2.2

2.3

—

(40761873) Peanut recombinant (rAra h) 1 IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.0

—

0.17

—

(3002670) Multiple inhalant allergen IgE Ab [Units/volume] in Serum

0.00

0.20

0.0

1.3

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.20

0.0

3.1

—

23.26

—

(4034850) Laboratory test

0.00

0.20

0.0

6.1

—

(3008898) HLA-B27 [Presence]

1.19

0.20

1.2

1.0

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

196

1.16

0.18

26.0

12.3

1.13

0.59

mmol/l

0.68

150

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.76

0.17

2.2

2.0

—

(40768797) Stomach Pathology biopsy report

1.12

0.15

1.2

1.3

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

0.83

0.14

2.4

1.6

621.38

463.53

pmol/l

—

(3044889) 12 lead EKG panel

379

1.09

0.12

3.6

2.7

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

204

1.10

0.09

35.0

17.6

24.59

24.15

mmol/l

0.29

204

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.15

0.09

1.4

—

(40761536) Microorganisms panel - Urine sediment

1.14

0.09

7.2

2.5

—

(40761511) CBC panel - Blood by Automated count

816

1.12

0.09

24.4

10.2

—

(3019832) Treponema pallidum Ab [Presence] in Serum

119

1.11

0.06

3.0

1.6

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

130

1.09

0.05

4.9

2.2

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

142

1.07

0.02

5.2

2.3

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.89

0.00

1.7

1.5

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

-0.00

0.0

1.0

—

(3017115) Methotrexate [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

20.6

—

0.77

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.1

—

129.49

—

(3034368) Herpes virus 6 IgM Ab [Presence] in Cerebral spinal fluid

0.00

-0.00

0.0

1.1

—

(3005011) Chlamydia sp Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3043257) Herpes virus 6 IgG Ab [Presence] in Cerebral spinal fluid

0.00

-0.00

0.0

1.2

—

(3031072) Herpes simplex virus 1 IgG Ab [Presence] in Cerebral spinal fluid

0.00

-0.00

0.0

1.1

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.1

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

-0.00

0.0

1.0

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(42870298) TPMT gene c.238G>C+460G>A+719A>G [Identifier] in Blood or Tissue by Molecular genetics method Narrative

0.00

-0.00

0.0

1.0

—

(3007695) Herpes simplex virus 2 IgG Ab [Presence] in Cerebral spinal fluid

0.00

-0.00

0.0

1.1

—

(21494434) Karyotype in Bone marrow

0.00

-0.00

0.0

1.4

—

(3006257) Acetylcholine receptor Ab [Moles/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3032352) Blasts [#/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

6.6

—

(3005593) Pancreatic islet cell Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

-0.00

0.0

4.0

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

-0.00

0.0

1.7

—

(3035401) Herpes virus 6 DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

5.8

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

-0.00

0.0

1.0

—

(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

1.0

—

137.00

—

(3000012) Reticulocyte production index

0.00

-0.00

0.0

1.8

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

23.4

—

1383.86

—

(3005791) Eosinophil cationic protein (ECP) [Mass/volume] in Serum

0.00

-0.00

0.0

2.0

—

25.05

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

-0.00

0.0

4.6

—

32.88

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

-0.00

0.0

1.7

—

(3029715) Chromosome analysis.interphase [Interpretation] in Bone marrow by FISH Narrative

0.00

-0.00

0.0

1.3

—

(3032641) Amino acids panel - Urine

0.00

-0.00

0.0

1.6

—

(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay

0.00

-0.00

0.0

2.6

—

107.71

—

(3016273) Islet cell 512 Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3022575) Varicella zoster virus IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.1

—

1221.71

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

-0.00

0.0

1.0

—

(3013924) Clostridium tetani IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.3

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

22.3

—

880.29

—

(40760109) Toxoplasma gondii IgG Ab avidity [Ratio] in Serum by Immunoassay

0.00

-0.00

0.0

1.3

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3032567) Hepatitis B virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

0.00

-0.00

0.0

2.8

—

(3018921) Toxoplasma gondii IgA Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.3

—

(3004905) Lipase [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

3.6

—

18.20

—

(42869858) Acute and chronic leukemia fusion transcript panel - Blood or Tissue by Molecular genetics method

0.00

-0.00

0.0

1.8

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

5.0

—

3.45

—

(3007798) IgG/Albumin [Mass Ratio] in Cerebral spinal fluid

0.00

-0.00

0.0

1.6

—

(3024474) Albumin [Mass/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

148.11

—

(3013247) Albumin in CSF/Albumin in Serum or Plasma

0.00

-0.00

0.0

1.0

—

3.33

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

-0.00

0.0

3.0

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.5

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

-0.00

0.0

4.1

—

(42868417) European tick borne encephalitis virus IgG Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.6

—

(40767663) Brazil Nut recombinant (rBer e) 1 IgE Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.4

—

(40758292) HTLV I+II Ab panel - Serum

0.00

-0.00

0.0

1.4

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.2

—

(3014373) Corynebacterium diphtheriae Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.6

—

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: Z21_NEED_IMMUNI_SINGLE_BACTERIAL_DISEA – Need for immunization against single bacterial diseases

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

≡ Risteys

R13

FinnGen R12 + FinRegistry

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Need for immunization against single bacterial diseases

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Need for immunization against single bacterial diseases (Z21_NEED_IMMUNI_SINGLE_BACTERIAL_DISEA)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Relationships between endpoints