Need for immunization against single bacterial diseases

Z21_NEED_IMMUNI_SINGLE_BACTERIAL_DISEA

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — Z23 Cause of death: ICD-10 — Z23 2 out of 7 registries used, show all original rules.	78
4. Check minimum number of events None	78
5. Include endpoints None	78
6. Filter based on genotype QC (FinnGen only)	78

Control definitions (FinnGen only)

Control exclude: Z21_PERSONS_W_POTEN_HEALTH_HAZARDS_RELATED_COMMUNICAB_DISEA

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: Z2

NAME	Z21_NEED_IMMUNI_SINGLE_BACTERIAL_DISEA
CONTROL_EXCLUDE	Z21_PERSONS_W_POTEN_HEALTH_HAZARDS_RELATED_COMMUNICAB_DISEA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	Z23
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	Z23
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Need for immunization against single bacterial diseases based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	78	50	28
Unadjusted period prevalence (%)	0.02	0.02	0.01
Median age at first event (years)	13.01	11.51	15.70

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
72: Matched controls
715

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

Z23.2

ICD-10 Finland

Need for immunization against tuberculosis [BCG]

+∞

41.6

Z23.8

ICD-10 Finland

Need for immunization against other single bacterial diseases

+∞

18.5

WW200

NOMESCO Finland

Immunization

54.0

14.8

Z23.5

ICD-10 Finland

Need for immunization against tetanus alone

70.2

10.9

190

Kela drug reimbursment

Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide

+∞

8.5

Z49.1

ICD-10 Finland

Extracorporeal dialysis

88.0

7.5

Z49.0

ICD-10 Finland

Preparatory care for dialysis

+∞

7.4

123

Kela drug reimbursment

Chronic disorders of vitamin D metabolism

22.6

7.3

N18.9

ICD-10 Finland

Chronic kidney disease, unspecified

25.1

6.8

A11CC03

ATC

alfacalcidol; systemic

16.1

6.6

TK800

NOMESCO Finland

Hemodialysis

20.0

6.4

138

Kela drug reimbursment

Severe anaemia associated with chronic renal failure

29.3

6.3

V03AE02

ATC

sevelamer; oral

+∞

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3042602) Urea [Moles/volume] in Serum or Plasma --post dialysis

+∞

6.33

13.3

0.0

3.0

—

mmol/l

—

(3037121) Protein [Mass/volume] in Urine

3.99

3.94

11.4

13.5

0.4

0.9

g/l

0.69

(3003458) Phosphate [Moles/volume] in Serum or Plasma

163

2.50

3.58

23.8

11.1

1.2

1.4

mmol/l

2.11

158

(3025941) Bacteria identified in Stool by Culture

4.10

3.48

1.2

1.1

—

(3005715) Vancomycin [Mass/volume] in Serum or Plasma

7.56

3.44

6.7

9.5

8.8

9.3

mg/l

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

3.95

3.32

2.2

3.6

—

(3015736) pH of Urine

217

2.34

3.31

3.8

3.3

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

164

2.35

3.12

3.2

3.4

—

(40768446) Kidney Pathology biopsy report

8.00

3.11

2.3

2.6

—

(3026782) Osmolality of Urine

134

2.41

3.08

4.6

2.6

498.5

542.3

mosm/kgh2o

0.51

109

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.52

2.86

3.7

1.6

—

(3018095) Leukocytes [#/volume] in Urine

255

2.17

2.82

8.2

4.8

44.0

32.5

e6/l

0.15

179

(40758558) Short blood count panel - Blood

225

2.11

2.62

8.1

8.5

—

(3042733) HLA Ab [Presence] in Serum

7.53

2.58

6.8

2.7

—

(3022621) pH of Urine by Test strip

4.12

2.54

3.1

1.7

—

(3052851) Hemolysis interference index of Serum or Plasma

3.93

2.44

6.0

2.4

—

(3021601) Nitrite [Presence] in Urine by Test strip

284

2.04

2.43

7.3

4.9

0.0

estimate

—

(3035350) Ketones [Presence] in Urine by Test strip

284

2.04

2.43

4.7

3.2

0.0

estimate

—

(3009261) Glucose [Presence] in Urine by Test strip

284

2.04

2.43

4.8

3.2

0.0

estimate

—

(3021447) Carbon dioxide [Partial pressure] in Venous blood

155

2.13

2.42

21.1

11.4

5.9

5.6

kpa

1.33

155

(3022411) Androstenedione [Moles/volume] in Serum or Plasma

6.58

2.40

1.4

2.8

2.7

1.7

nmol/l

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

133

2.16

2.34

3.3

1.8

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

142

2.12

2.28

6.1

3.8

0.9

0.8

e6/l

0.04

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

3.59

2.25

1.8

1.5

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

3.59

2.25

1.8

1.5

—

(3024354) Oxygen [Partial pressure] in Venous blood

151

2.08

2.24

10.5

11.2

6.8

5.4

kpa

0.76

151

(4035726)

2.71

2.23

1.5

1.8

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

137

2.09

2.15

6.3

3.8

4.2

2.5

e6/l

0.22

(3030467) Casts [#/volume] in Urine by Automated count

212

1.96

2.14

7.6

3.9

0.7

0.4

e6/l

0.19

157

(42870588) Differential panel, method unspecified - Blood

303

1.93

2.13

11.8

10.3

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

239

1.94

2.12

7.3

4.0

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

3.55

2.01

1.3

1.7

—

(3000991) Gas panel - Venous blood

141

2.01

1.98

34.8

11.7

—

(3026008) Bacteria identified in Urine by Culture

142

2.00

1.94

3.1

2.5

—

(36304419) Bacteria [Presence] in Urine

213

1.85

1.82

7.9

3.8

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.50

1.80

3.2

1.6

—

(3002582) Erythrocytes [#/volume] in Urine

223

1.83

1.78

7.7

3.9

12.1

304.1

e6/l

0.51

171

(3013139) Helicobacter pylori Ag [Presence] in Stool

2.85

1.78

1.1

1.2

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

3.10

1.77

2.4

2.0

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

2.67

1.65

1.3

1.5

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

2.67

1.65

1.6

2.5

—

(3002173) Hemoglobin [Mass/volume] in Arterial blood

2.67

1.65

31.0

11.9

109.8

123.0

g/l

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

158

1.86

1.65

4.1

3.0

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

3.74

1.64

1.4

2.6

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

3.16

1.61

2.2

1.0

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

3.16

1.61

2.7

1.2

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

3.16

1.61

2.2

1.0

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

118

1.93

1.61

3.0

1.7

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

2.20

1.59

6.0

9.4

90.5

87.3

0.18

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

2.35

1.59

4.0

9.0

160.4

168.8

0.16

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.01

1.59

3.0

2.0

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.01

1.59

3.4

2.1

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

2.74

1.55

2.3

1.7

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

2.54

1.51

1.2

1.3

—

(3042936) Bacteria identified in Isolate by Culture

1.96

1.50

3.5

1.9

—

(42529406) Shigella sp [Presence] in Stool by Culture

2.87

1.46

4.5

1.0

—

(3023368) Bacteria identified in Blood by Culture

130

1.84

1.46

9.0

3.9

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.55

1.43

67.6

15.2

—

(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma

2.74

1.39

4.5

4.7

28.5

30.4

umol/l

—

(3032773) Endomysium IgG Ab [Titer] in Serum

2.74

1.39

1.0

1.1

—

(3009542) Hematocrit [Volume Fraction] of Blood

665

2.52

1.39

43.5

16.8

37.0

38.7

1.32

588

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

1.97

1.39

4.3

5.0

0.2

g/l

0.31

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

116

1.84

1.37

3.4

5.2

1.9

3.7

mg/l

0.47

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

2.50

1.33

4.1

2.3

—

(3016502) Oxygen saturation in Arterial blood

2.18

1.32

53.1

13.3

95.8

96.9

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

2.43

1.31

2.1

1.9

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

414

1.67

1.30

4.4

3.3

1.2

1.3

mmol/l

0.59

385

(3007164) IgA [Mass/volume] in Serum or Plasma

241

1.64

1.27

1.6

1.4

1.6

g/l

0.47

115

(3024928) Oxygen saturation in Venous blood

2.51

1.27

8.3

23.5

—

(3021589) Normoblasts [#/volume] in Blood

377

1.62

1.23

12.7

10.8

0.0

e9/l

0.50

260

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

252

1.62

1.23

1.9

1.8

0.4

6.1

u/ml

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

338

1.61

1.22

6.2

4.5

34.8

33.5

u/l

0.05

330

(3044640) Blood type and Crossmatch panel - Blood

181

1.65

1.20

5.0

3.3

—

(3016543) Leukocytes [#/volume] in Cerebral spinal fluid

0.00

1.19

0.0

4.3

—

4.2

—

(3027475) Erythrocytes [#/volume] in Cerebral spinal fluid

0.00

1.19

0.0

4.3

—

1044.8

—

(3019473) Protein [Mass/volume] in Cerebral spinal fluid

0.00

1.19

0.0

3.8

—

379.7

—

(3011648) Oxygen content in Venous blood

2.60

1.17

9.8

24.2

9.8

11.5

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

2.30

1.11

35.6

24.7

133.9

124.3

g/l

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

2.30

1.11

2.4

1.8

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

2.47

1.10

1.0

1.1

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

2.08

1.08

5.1

1.5

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.08

1.08

1.4

1.6

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.16

1.06

1.9

2.2

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

2.16

1.06

4.6

2.3

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.94

1.04

4.7

1.6

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

118

1.68

1.02

3.5

2.1

—

(3023410) Appearance of Cerebral spinal fluid

0.00

1.00

0.0

4.0

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

253

1.53

0.99

5.4

4.4

—

(3020044) Glucose [Moles/volume] in Cerebral spinal fluid

0.00

0.99

0.0

3.8

—

3.5

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.97

0.0

4.4

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

592

1.75

0.96

4.4

3.7

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

421

1.52

0.96

4.7

3.5

1.4

1.5

mmol/l

0.37

393

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

2.01

0.92

3.9

2.2

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

2.01

0.92

4.0

2.4

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.08

0.89

1.0

1.8

—

(3013707) Erythrocyte sedimentation rate by Westergren method

425

1.49

0.88

4.4

4.2

11.9

8.6

mm/h

0.52

396

(3005719) IgG [Mass/volume] in Serum or Plasma

1.73

0.84

4.3

3.6

9.8

7.5

g/l

1.13

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

1.73

0.84

1.1

—

(44790047)

1.95

0.83

4.5

2.4

—

(44790048)

1.95

0.83

4.5

2.4

—

(44790049)

1.95

0.83

4.5

2.4

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

1.95

0.83

1.2

1.3

—

(3035637) Corticotropin [Mass/volume] in Plasma

1.95

0.83

1.5

2.0

—

(44806118)

1.95

0.83

4.5

2.4

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

428

1.47

0.83

5.2

3.8

2.6

2.7

mmol/l

0.24

400

(3037467) Urinalysis macro (dipstick) panel - Urine

408

1.46

0.82

8.4

4.0

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.83

0.78

8.3

19.7

0.8

1.6

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

624

1.70

0.78

25.9

11.6

83.8

58.6

umol/l

1.62

624

(3019230) Fractional oxyhemoglobin in Venous blood

2.25

0.77

9.8

21.4

64.2

73.7

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

2.25

0.77

43.8

10.2

26.6

24.3

mmol/l

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

2.15

0.76

1.0

1.1

—

(3032080) INR in Blood by Coagulation assay

154

1.50

0.75

4.1

5.1

1.1

inr

—

(40768804) Tissue Pathology biopsy report

172

1.48

0.75

2.0

1.9

—

(3027008) Opiates [Presence] in Urine

1.78

0.72

1.3

2.1

—

(3028300) Cannabinoids [Presence] in Urine

1.78

0.72

1.3

2.1

—

(3000330) Specific gravity of Urine by Test strip

1.98

0.72

3.8

1.7

—

(3000764) Benzodiazepines [Presence] in Urine

1.73

0.70

1.3

2.1

—

(3027944) Amphetamines [Presence] in Urine

1.73

0.70

1.3

2.1

—

(3002523) Influenza virus A Ag [Presence] in Specimen

1.84

0.67

1.0

1.3

—

(3003740) Influenza virus B Ag [Presence] in Specimen

1.84

0.67

1.0

1.3

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.65

0.67

2.3

1.3

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

1.77

0.65

3.2

1.8

—

(3021387) Prolactin [Units/volume] in Serum or Plasma

1.77

0.65

1.8

1.6

403.6

383.0

mu/l

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

1.71

0.62

1.0

1.5

—

(40761872) Peanut recombinant (rAra h) 2 IgE Ab [Units/volume] in Serum

0.00

0.60

0.0

1.3

—

6.3

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.54

0.59

1.9

2.0

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

0.59

0.0

4.7

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

1.72

0.58

1.5

1.4

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

144

1.42

0.58

2.0

1.8

104.2

90.7

pmol/l

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.59

0.57

1.1

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.51

0.57

2.4

1.6

—

(3014007) Fractional oxyhemoglobin in Arterial blood

1.67

0.57

79.0

14.2

93.8

95.2

—

(36660697) Celiac disease serology panel - Serum

118

1.45

0.56

1.5

1.2

—

(3003694) ABO and Rh group [Type] in Blood

201

1.36

0.54

2.0

1.5

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

1.58

0.54

79.0

13.4

0.7

—

(3016879) Cocaine [Presence] in Urine

1.58

0.54

1.3

2.2

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

1.58

0.54

79.0

13.4

0.9

1.1

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

1.54

0.53

1.0

1.2

—

(3029937) Albumin [Presence] in Urine by Test strip

129

1.41

0.51

5.1

3.1

0.0

estimate

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

369

1.30

0.49

24.0

9.2

78.9

93.8

ml/min/173m2

1.71

294

(3022145) Colonoscopy Study observation

1.50

0.48

2.6

1.3

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.47

0.48

3.2

1.5

—

(3041096) Erythrocytes [Presence] in Urine by Automated

140

1.37

0.47

5.4

2.4

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

1.44

0.46

1.6

—

(4010399)

1.60

0.43

1.4

1.6

—

(3011288) Drugs identified in Urine by Screen method

1.60

0.43

1.2

2.7

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

169

0.72

0.42

1.9

—

(3033386) Bacteria [Presence] in Cerebral spinal fluid by Light microscopy

0.00

0.41

0.0

1.4

—

(3008733) Herpes simplex virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.41

0.0

1.3

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.41

0.0

1.1

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.41

0.0

1.3

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.41

0.0

1.4

—

(3027231) Wheat IgE Ab [Units/volume] in Serum

0.00

0.41

0.0

1.2

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.41

0.0

4.5

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

0.40

0.0

1.4

—

(3000494) Fungus identified in Specimen by Culture

1.37

0.39

1.8

1.4

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.39

0.0

1.8

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

1.41

0.39

1.4

2.2

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

230

1.27

0.38

2.0

1.8

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.46

0.36

1.3

3.6

4.8

5.2

pmol/l

—

(3027901) Hemoglobin [Mass/volume] in Arterial cord blood

1.43

0.36

1.0

157.0

163.4

g/l

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

194

1.26

0.35

5.1

2.8

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

1.33

0.34

1.7

1.5

—

(3002256) Pathology report gross observation

1.27

0.30

1.3

—

(40760892) CBC W Ordered Manual Differential panel - Blood

134

1.24

0.25

7.5

6.4

—

(3006598) pH of Arterial cord blood

1.30

0.23

1.0

—

(3003327) Ova and parasites identified in Stool by Light microscopy

1.27

0.23

3.0

1.6

—

(3028433) Virus identified in Specimen by Culture

0.00

0.21

0.0

1.5

—

(4034850)

0.00

0.21

0.0

7.0

—

(3016031) Almond IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.3

—

1.4

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.21

0.0

1.5

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.21

0.0

1.2

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.2

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.2

—

(1761868) Lipid panel - Serum or Plasma

156

1.20

0.21

2.3

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.21

0.0

1.1

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

3.2

—

23.9

—

(40768793) Breast Pathology biopsy report

0.00

0.21

0.0

1.5

—

(40761873) Peanut recombinant (rAra h) 1 IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.0

—

0.2

—

(40761536) Microorganisms panel - Urine sediment

1.27

0.21

7.2

2.4

—

(3002670) Multiple inhalant allergen IgE Ab [Units/volume] in Serum

0.00

0.20

0.0

1.6

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

110

1.22

0.18

2.7

3.5

30.0

26.9

ng/l

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

112

1.19

0.15

5.8

2.5

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

104

1.18

0.13

5.6

2.4

—

(3044889) 12 lead EKG panel

275

1.09

0.08

3.1

2.7

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

0.83

0.08

2.3

1.7

713.8

486.5

pmol/l

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

197

1.09

0.07

36.6

17.7

24.6

24.2

mmol/l

0.26

197

(40761511) CBC panel - Blood by Automated count

650

1.10

0.05

27.6

10.3

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

188

1.01

0.00

29.4

12.7

1.2

0.6

mmol/l

0.64

146

(3022313) Gas panel - Capillary blood

165

1.04

0.00

30.0

12.6

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

4.3

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.2

—

139.1

—

(3043257) Herpes virus 6 IgG Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.2

—

(3013924) Clostridium tetani IgG Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(3001964) Herpes simplex virus Ag [Presence] in Specimen

0.00

0.0

4.2

—

(3005593) Pancreatic islet cell Ab [Titer] in Serum

0.00

0.0

1.0

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.0

—

(3007695) Herpes simplex virus 2 IgG Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.2

—

(3031072) Herpes simplex virus 1 IgG Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.2

—

(3005791) Eosinophil cationic protein (ECP) [Mass/volume] in Serum

0.00

0.0

2.0

—

25.0

—

(3000012) Reticulocyte production index

0.00

0.0

1.8

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.0

3.3

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.0

4.6

—

32.9

—

(3049714) Procollagen type I.N-terminal propeptide [Mass/volume] in Serum

0.00

0.0

8.8

—

255.8

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

0.00

0.0

2.3

—

1.4

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.0

1.6

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.3

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.6

—

(40758292) HTLV I+II Ab panel - Serum

0.00

0.0

1.4

—

(3002823) Mycoplasma pneumoniae IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.1

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

3.2

—

4.0

—

(3013512) EKG study

0.95

0.00

5.0

3.1

—

(3014373) Corynebacterium diphtheriae Ab [Units/volume] in Serum

0.00

0.0

1.6

—

(4268621)

0.00

0.0

2.1

—

(3037677) Mycoplasma pneumoniae IgM Ab [Titer] in Cerebral spinal fluid

0.00

0.0

1.1

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.8

—

6.3

—

(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay

0.00

0.0

3.2

—

109.4

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.0

1.6

—

(3016273) Islet cell 512 Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.4

—

(3013247) Albumin in CSF/Albumin in Serum or Plasma

0.00

0.0

1.0

—

3.3

—

(3035401) Herpes virus 6 DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

5.8

—

(3017115) Methotrexate [Moles/volume] in Serum or Plasma

0.00

0.0

20.6

—

0.8

—

(3032352) Blasts [#/volume] in Cerebral spinal fluid

0.00

0.0

6.6

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

0.0

4.6

—

(42869858) Acute and chronic leukemia fusion transcript panel - Blood or Tissue by Molecular genetics method

0.00

0.0

1.8

—

(3024474) Albumin [Mass/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

113.4

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.0

2.4

—

(40767663) Brazil Nut recombinant (rBer e) 1 IgE Ab [Units/volume] in Serum

0.00

0.0

1.4

—

(40760109) Toxoplasma gondii IgG Ab avidity [Ratio] in Serum by Immunoassay

0.00

0.0

1.4

—

(40768797) Stomach Pathology biopsy report

0.86

0.00

1.3

—

(3034368) Herpes virus 6 IgM Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.1

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.0

1.5

—

(3029715) Chromosome analysis.interphase [Interpretation] in Bone marrow by FISH Narrative

0.00

0.0

1.3

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.0

1.5

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.0

1.0

—

(21494434) Karyotype in Bone marrow

0.00

0.0

1.4

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.3

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(3028772) Osteocalcin [Mass/volume] in Serum or Plasma

0.00

0.0

2.2

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.99

0.00

1.4

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.0

1.5

—

(4027681)

0.00

0.0

1.1

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.0

1.6

—

(3018921) Toxoplasma gondii IgA Ab [Units/volume] in Serum

0.00

0.0

1.4

—

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: Z21_NEED_IMMUNI_SINGLE_BACTERIAL_DISEA – Need for immunization against single bacterial diseases

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Need for immunization against single bacterial diseases

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Need for immunization against single bacterial diseases (Z21_NEED_IMMUNI_SINGLE_BACTERIAL_DISEA)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Relationships between endpoints