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Tic and related disorders

Endpoint Browser PheWeb

KRA_PSY_TIC_EXMORE

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

-

2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F95
  • Hospital discharge: ICD-9 — 3072
  • Hospital discharge: ICD-8 — 30620
  • Cause of death: ICD-10 — F95
  • Cause of death: ICD-9 — 3072
  • Cause of death: ICD-8 — 30620

2 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

None

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Control exclude
KRA_PSY_ANYMENTAL

Extra metadata

First used in FinnGen datafreeze
DF12
Parent code in ICD-10
F90-F98
Name in latin
Perturbationes ticiformes

Case counts by codes

↥

FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 12184 3427 8742
Only index persons 9944 2898 7046
Unadjusted period prevalence (%)
Whole population 0.20 0.10 0.24
Only index persons 0.22 0.11 0.27
Median age at first event (years)
Whole population 9.93 10.84 9.52
Only index persons 10.81 12.11 10.28

-FinnGen-

Key figures

All Female Male
Number of individuals 499 262 237
Unadjusted period prevalence (%) 0.10 0.09 0.11
Median age at first event (years) 15.11 17.72 12.22

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
534
Matched controls
5340
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N05AX08
ATC
risperidone; systemic
125.7
300.6
153
17
F95.9
ICD-10 Finland
Tic disorder, unspecified
+∞
216.9
193
*
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
19.4
205.4
185
142
F95.2
ICD-10 Finland
Combined vocal and multiple motor tic disorder [de la Tourette]
2959.0
204.9
185
*
N05AH04
ATC
quetiapine; oral
17.5
182.0
171
140
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
59.5
143.0
81
16
ZY010
NOMESCO Finland
Hospital outpatient
24.4
134.0
100
50
F90.0
ICD-10 Finland
Disturbance of activity and attention
16.2
126.2
117
91
N05AX12
ATC
aripiprazole; systemic
+∞
125.0
115
*
IGY99
NOMESCO Finland
Other psychiatric treatment contact
70.7
124.1
68
11
N03AE01
ATC
clonazepam; systemic
45.1
122.9
74
19
N06AB06
ATC
sertraline; oral
12.9
118.7
128
127
F95.0
ICD-10 Finland
Transient tic disorder
+∞
116.0
107
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
12.8
113.9
123
122
N06BA04
ATC
methylphenidate; oral
15.5
112.7
106
84
N06AX16
ATC
venlafaxine; oral
13.4
105.9
109
100
N06AB03
ATC
fluoxetine; oral
14.4
102.4
100
84
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
16.3
97.8
88
64
IGY02
NOMESCO Finland
Psychiatric monitoring contact
32.9
97.6
64
22
F95.1
ICD-10 Finland
Chronic motor or vocal tic disorder
+∞
96.9
90
*
N03AX09
ATC
lamotrigine; oral
30.9
94.1
63
23
N05BA04
ATC
oxazepam; oral
7.4
93.4
169
314
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
41.6
91.5
56
15
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
336.8
86.4
85
*
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
27.5
84.8
59
24
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
322.2
83.1
82
*
Z2445
NOMESCO Finland
Psychologist
13.7
82.7
82
70
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
7.7
82.4
136
227
N05AH03
ATC
olanzapine; systemic
196.0
81.7
83
5
ICC04
NOMESCO Finland
Psychiatric treatment plan, permanent discontinuation
43.9
79.6
48
12
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
158.7
78.4
81
6
N06AX12
ATC
bupropion; oral
12.5
75.6
79
73
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
40.9
73.3
45
12
N03AG01
ATC
valproic acid; systemic, rectal
17.2
70.2
60
39
T36
ICD-10 Finland
Poisoning by systemic antibiotics
34.2
68.2
44
14
331
Kela drug reimbursment
Atomoxetine, dexamphetamine, guanfacine and lisdexamphetamine
31.9
66.8
44
15
ZYC01
NOMESCO Finland
Remote contact by phone
12.2
66.6
70
65
IBZ01
NOMESCO Finland
Profession-specific psychiatric evaluation
372.9
66.0
65
*
N06AB10
ATC
escitalopram; oral
5.7
65.5
152
350
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
145.1
61.3
64
5
F29
ICD-10 Finland
Unspecified nonorganic psychosis
659.2
61.0
59
*
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
8.4
59.3
84
116
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
9.6
58.9
74
88
N05AD01
ATC
haloperidol; systemic
101.9
58.3
63
7
IBA04
NOMESCO Finland
Extensive initial psychiatric evaluation
212.2
56.2
57
*
N06AX26
ATC
vortioxetine; oral
8.2
51.3
73
101
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
20.0
49.6
39
21
N05BA01
ATC
diazepam; systemic, rectal
6.9
49.4
83
138
N06AX11
ATC
mirtazapine; oral
4.3
48.8
165
505
IBA01
NOMESCO Finland
Diagnostic and symptom-mapping evaluation
140.6
48.7
51
*
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
9.2
48.5
62
75
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
10.3
48.0
56
60
N06AB04
ATC
citalopram; systemic
6.2
47.9
91
171
IFA01
NOMESCO Finland
Psychiatric pharmacotherapy plan, not specified
+∞
47.6
45
*
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
13.2
46.8
46
38
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
5.0
41.6
101
236
IGP01
NOMESCO Finland
Psychiatric family contact
81.5
40.6
45
6
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
6.4
40.5
72
126
F84.5
ICD-10 Finland
Asperger syndrome
405.0
38.6
38
*
F32.00
ICD-10 Finland
Mild depressive episode without somatic syndrome
12.7
38.0
38
32
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
7.8
38.0
55
77
Z2446
NOMESCO Finland
Social worker
5.5
37.9
80
165
IBZ06
NOMESCO Finland
Evaluation concerning developmental neuropsychiatry
+∞
36.9
35
*
P74
ICPC
Anxiety disorder/anxiety state
7.9
36.2
52
72
ICB03
NOMESCO Finland
Psychiatric treatment plan, monitoring
370.4
35.4
35
*
IGV01
NOMESCO Finland
Psychiatric network contact
370.4
35.4
35
*
F42.2
ICD-10 Finland
Mixed obsessional thoughts and acts
84.1
35.3
39
5
C07AA05
ATC
propranolol; systemic
3.8
35.1
131
421
SPAT1240
SPAT
Therapeutic discussion
4.2
34.9
107
299
ZXY51
NOMESCO Finland
2-person team, doctor-nurse
+∞
34.8
33
*
P76
ICPC
Depressive disorder
7.1
34.7
55
85
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
81.8
34.3
38
5
N06AB05
ATC
paroxetine; oral
10.2
33.7
39
41
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
+∞
32.6
31
*
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
11.6
32.3
34
31
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.9
31.8
77
178
F95.8
ICD-10 Finland
Other tic disorders
+∞
31.6
30
*
IDY03
NOMESCO Finland
Systematic individual therapy, cognitive-behavioural
64.1
31.5
36
6
F93.89
ICD-10 Finland
Other childhood emotional disorders
169.8
31.0
32
*
Z3231
NOMESCO Finland
Registered nurse
3.1
30.9
185
789
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
+∞
30.5
29
*
F83
ICD-10 Finland
Mixed specific developmental disorders
+∞
30.5
29
*
30620
ICD-8 Finland
Special symptoms not elsewhere classified, Tics
+∞
30.5
29
*
P29
ICPC
Psychological sympt/compl other
4.6
30.5
79
193
N06AX21
ATC
duloxetine; oral
6.0
30.3
57
105
P99
ICPC
Psychological disorders other
12.7
30.1
30
25
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
7.6
28.8
42
59
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
10.6
28.5
32
32
F41.1
ICD-10 Finland
Generalized anxiety disorder
6.1
28.4
52
93
ICB02
NOMESCO Finland
Psychiatric treatment plan, extended/prolonged
+∞
28.4
27
*
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
35.0
28.1
36
11
P03
ICPC
Feeling depressed
3.8
28.1
100
308
F42.9
ICD-10 Finland
Obsessive-compulsive disorder, unspecified
82.2
28.1
31
*
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
5.9
28.0
53
98
SPAT1307
SPAT
Psychosocial counselling and guidance
4.0
27.7
89
255
F80.1
ICD-10 Finland
Expressive language disorder
+∞
26.3
25
*
F40.1
ICD-10 Finland
Social phobias
9.4
26.2
32
36
XA800
NOMESCO Finland
Neuropsychological investigation
6.4
25.5
44
74
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
+∞
25.2
24
*
SPAT1243
SPAT
Psychiatric/psychological examination
5.9
25.1
47
86
IEV99
NOMESCO Finland
Other psychiatric network intervention
261.7
24.9
25
*
N05CF01
ATC
zopiclone; oral
3.3
24.3
106
371
Z03.2
ICD-10 Finland
Observation for suspected mental and behavioural disorders
21.9
24.2
35
17
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
+∞
24.1
23
*
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
+∞
24.1
23
*
F41.8
ICD-10 Finland
Other specified anxiety disorders
7.2
24.1
37
55
F42.0
ICD-10 Finland
Predominantly obsessional thoughts or ruminations
87.3
22.9
25
*
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
5.2
22.7
49
102
IFA99
NOMESCO Finland
Other psychiatric pharmacotherapy service
+∞
22.0
21
*
F42.1
ICD-10 Finland
Predominantly compulsive acts [obsessional rituals]
83.7
21.8
24
*
N04AA02
ATC
biperiden; systemic
+∞
21.0
20
*
N03AX12
ATC
[U] gabapentin; oral
4.0
20.9
65
181
N05AB03
ATC
perphenazine; systemic, rectal
218.2
20.7
21
*
F34.1
ICD-10 Finland
Dysthymia
26.8
20.6
28
11
F33.4
ICD-10 Finland
Recurrent depressive disorder, currently in remission
28.3
20.2
27
10
R56.8
ICD-10 Finland
Other and unspecified convulsions
4.5
19.8
51
123
P01
ICPC
Feeling anxious/nervous/tense
2.7
19.7
132
581
F99
ICD-10 Finland
Mental disorder, not otherwise specified
41.8
19.7
24
6
N03AX16
ATC
[U] pregabalin
3.4
19.6
78
256
N05CD07
ATC
temazepam; oral
6.6
19.5
32
51
F33.00
ICD-10 Finland
Recurrent depression, mild episode without somatic syndrome
32.7
19.4
25
8
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
6.2
19.4
34
58
N06BA12
ATC
lisdexamfetamine; oral
21.0
19.3
28
14
N06AA04
ATC
clomipramine; systemic
72.6
18.8
21
*
F43.1
ICD-10 Finland
Post-traumatic stress disorder
14.2
18.5
31
23
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
4.6
18.4
45
104
F31.8
ICD-10 Finland
Other bipolar affective disorders
54.5
18.1
21
*
N05BA12
ATC
alprazolam; oral
5.2
17.8
38
78
ZXY82
NOMESCO Finland
Nurse in multidisciplinary team
+∞
17.8
17
*
N05AH02
ATC
clozapine; systemic
+∞
17.8
17
*
N05AA02
ATC
levomepromazine; systemic
38.1
17.7
22
6
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
4.8
17.3
40
88
R53
ICD-10 Finland
Malaise and fatigue
2.5
17.3
128
588
N06AA09
ATC
amitriptyline; systemic
6.2
17.2
30
51
N06BA09
ATC
atomoxetine; oral
32.7
17.2
22
7
IEP99
NOMESCO Finland
Other psychiatric family intervention
51.8
17.1
20
*
3072A
ICD-9 Finland
Special symptoms or syndromes not elsewhere classified, Tics[NYKIMISHÄIRIÖ, MÄÄRITTELEMÄTÖN]
+∞
16.8
16
*
F84.9
ICD-10 Finland
Pervasive developmental disorder, unspecified
+∞
16.8
16
*
F98.8
ICD-10 Finland
Other specified behavioural and emotional disorders with onset usually occurring in childhood and adolescence
93.0
16.7
18
*
IBA03
NOMESCO Finland
Psychotherapy evaluation
175.2
16.6
17
*
F39
ICD-10 Finland
Unspecified mood [affective] disorder
24.0
16.6
23
10
N05AF03
ATC
chlorprothixene; systemic
49.1
16.1
19
*
N05BA06
ATC
lorazepam; systemic, sublingual
21.8
16.1
23
11
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.6
15.9
56
169
R42
ICD-10 Finland
Dizziness and giddiness
2.8
15.9
91
367
N05BE01
ATC
buspirone; oral
34.5
15.8
20
6
P72
ICPC
Schizophrenia
+∞
15.7
15
*
F88
ICD-10 Finland
Other disorders of psychological development
+∞
15.7
15
*
F92.8
ICD-10 Finland
Other mixed disorders of conduct and emotions
+∞
15.7
15
*
F61.0
ICD-10 Finland
Mixed personality disorders
87.7
15.6
17
*
F92.9
ICD-10 Finland
Mixed disorder of conduct and emotions, unspecified
164.6
15.6
16
*
N06AX22
ATC
agomelatine; oral
39.3
15.5
19
5
Z01.8
ICD-10 Finland
Other specified special examinations
2.5
15.5
110
494
F33.1
ICD-10 Finland
Recurrent depressive disorder, current episode moderate
13.6
15.3
26
20
T82
ICPC
Obesity
5.4
15.0
30
58
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.4
15.0
127
617
F41.09
ICD-10 Finland
UNS Panic Syndrome
11.3
14.7
27
25
F84.8
ICD-10 Finland
Other pervasive developmental disorders
+∞
14.6
14
*
F31.6
ICD-10 Finland
Bipolar affective disorder, current episode mixed
+∞
14.6
14
*
F31.30
ICD-10 Finland
Bipolar disorder Depressive episode without somatic syndrome
+∞
14.6
14
*
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
+∞
14.6
14
*
N05AG02
ATC
pimozide; oral
+∞
14.6
14
*
IER02
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, group
+∞
14.6
14
*
F10.09
ICD-10 Finland
Alcohol intoxication UNS
82.4
14.6
16
*
G24.5
ICD-10 Finland
Blepharospasm
82.4
14.6
16
*
F90.9
ICD-10 Finland
Hyperkinetic disorder, unspecified
17.6
14.4
22
13
ZY000
NOMESCO Finland
Hospital inpatient
28.1
14.4
19
7
F50.9
ICD-10 Finland
Eating disorder, unspecified
23.0
14.3
20
9
N02BF02
ATC
pregabalin; oral
5.3
14.3
29
57
SPAT1389
SPAT
Visit based on need for special support
3.3
14.0
57
189
N03AF01
ATC
carbamazepine; oral, rectal
11.3
13.6
25
23
F60.9
ICD-10 Finland
Personality disorder, unspecified
77.2
13.6
15
*
F20.30
ICD-10 Finland
Undifferentiated schizophrenia continuous
+∞
13.6
13
*
F50.0
ICD-10 Finland
Anorexia nervosa
+∞
13.6
13
*
N05AN01
ATC
lithium; oral
143.5
13.5
14
*
F31.7
ICD-10 Finland
Bipolar affective disorder, currently in remission
143.5
13.5
14
*
ZXY80
NOMESCO Finland
Doctor in multidisciplinary team
143.5
13.5
14
*
IAZ98
NOMESCO Finland
Other internal psychiatric consultation
143.5
13.5
14
*
F43.22
ICD-10 Finland
Adaptation disorder with mixed anxiety and depression
5.1
13.5
29
60
F51.0
ICD-10 Finland
Nonorganic insomnia
2.7
13.3
80
329
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
5.0
13.2
29
61
F33.11
ICD-10 Finland
Recurrent depression, moderate episode of somatic syndrome
41.2
13.2
16
*
SPAT1222
SPAT
Counselling/guidance promoting independent living
3.0
13.2
62
224
Z71.8
ICD-10 Finland
Other specified counselling
2.1
13.1
180
1056
F45.8
ICD-10 Finland
Other somatoform disorders
3.3
13.1
53
175
AA1AD
NOMESCO Finland
CT of head and brain
2.7
13.0
79
327
Z76.8
ICD-10 Finland
Persons encountering health services in other specified circumstances
4.9
13.0
29
62
ZXE20
NOMESCO Finland
More than three and less than five hours
3.0
12.9
62
226
Z3226
NOMESCO Finland
Physiotherapist
2.5
12.9
95
431
IER01
NOMESCO Finland
Psychoeducation, group
51.3
12.9
15
*
F82
ICD-10 Finland
Specific developmental disorder of motor function
51.3
12.9
15
*
J45.9
ICD-10 Finland
Asthma, unspecified
2.4
12.9
97
445
Z2221
NOMESCO Finland
Medical doctor
2.2
12.6
129
674
ZXE01
NOMESCO Finland
Procedure duration 0 to 9 minutes
11.4
12.6
23
21
IBB01
NOMESCO Finland
Psychiatric functioning capacity evaluation
+∞
12.5
12
*
F93.9
ICD-10 Finland
Childhood emotional disorder, unspecified
+∞
12.5
12
*
F81.3
ICD-10 Finland
Mixed disorder of scholastic skills
+∞
12.5
12
*
IAB01
NOMESCO Finland
Psychiatric pharmacotherapy consultation
+∞
12.5
12
*
G51.3
ICD-10 Finland
Clonic hemifacial spasm
133.0
12.5
13
*
L01
ICPC
Neck symptom/complaint
2.5
12.4
90
405
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.0
12.4
202
1255
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
3.1
12.4
53
181
Z00.8
ICD-10 Finland
Other general examinations
2.9
12.2
62
233
N07BB01
ATC
disulfiram; oral
12.8
12.2
21
17
P27
ICPC
Fear of mental disorder
10.4
12.1
23
23
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
3.9
12.0
36
97
A02BC02
ATC
pantoprazole; systemic
1.9
11.9
230
1508
R4110
NOMESCO Finland
Physiotherapy
2.2
11.9
125
659
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.3
11.9
99
474
F81.8
ICD-10 Finland
Other developmental disorders of scholastic skills
+∞
11.5
11
*
F84.0
ICD-10 Finland
Childhood autism
+∞
11.5
11
*
F95
ICD-10 Finland
Tic disorders
+∞
11.5
11
*
F33.30
ICD-10 Finland
Recurrent depression, severe episode without somatic syndrome
+∞
11.5
11
*
ZXY60
NOMESCO Finland
2-person team, nurses
+∞
11.5
11
*
F98.9
ICD-10 Finland
Unspecified behavioural and emotional disorders with onset usually occurring in childhood and adolescence
122.6
11.5
12
*
ZXY81
NOMESCO Finland
Psychologist in multidisciplinary team
122.6
11.5
12
*
F89
ICD-10 Finland
Unspecified disorder of psychological development
122.6
11.5
12
*
IEP03
NOMESCO Finland
Focused parental counselling
15.5
11.4
18
12
D01
ICPC
Abdominal pain/cramps general
2.3
11.3
98
477
G47.3
ICD-10 Finland
Sleep apnoea
2.6
11.3
72
305
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.2
11.2
105
528
R06.0
ICD-10 Finland
Dyspnoea
2.3
11.0
99
489
G40.9
ICD-10 Finland
Epilepsy, unspecified
5.6
11.0
21
39
Z76.0
ICD-10 Finland
Issue of repeat prescription
2.1
10.7
122
661
F31.0
ICD-10 Finland
Bipolar affective disorder, current episode hypomanic
112.1
10.5
11
*
IEY01
NOMESCO Finland
Psychoeducation, individual
112.1
10.5
11
*
F60.3
ICD-10 Finland
Emotionally unstable personality disorder
112.1
10.5
11
*
ZXY52
NOMESCO Finland
2-person team, doctor-psychologist
+∞
10.4
10
*
F20.9
ICD-10 Finland
Schizophrenia, unspecified
+∞
10.4
10
*
IAZ99
NOMESCO Finland
Other psychiatric consultation
+∞
10.4
10
*
RT420, ,
NOMESCO Finland
+∞
10.4
10
*
IER04
NOMESCO Finland
Rehabilitative psychiatric group intervention, functional
+∞
10.4
10
*
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
16.4
10.4
16
10
N03AF02
ATC
oxcarbazepine; oral
5.1
10.3
22
45
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
3.6
10.3
34
98
F32.8
ICD-10 Finland
Other depressive episodes
19.2
10.3
15
8
Z08
ICPC
Social welfare problem
23.9
10.3
14
6
H53.1
ICD-10 Finland
Subjective visual disturbances
3.5
10.2
36
109
O99.3
ICD-10 Finland
Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium
11.6
10.1
18
16
Z3229
NOMESCO Finland
Other healthcare associate professional
2.9
10.1
48
174
ZXE10
NOMESCO Finland
More than one and less than three hours
2.0
10.1
146
861
Z72.8
ICD-10 Finland
Other problems related to lifestyle
40.9
10.0
12
*
D09
ICPC
Nausea
2.7
10.0
58
234
SPAT1260
SPAT
Consultation of another employee
2.2
9.9
90
445
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
5.3
9.9
20
39
F41.0
ICD-10 Finland
Panic disorder [episodic paroxysmal anxiety]
4.8
9.8
22
47
A04
ICPC
Weakness/tiredness general
2.2
9.8
93
468
A06AD11
ATC
lactulose; oral
2.9
9.8
47
171
R51.80
ICD-10 Finland
Headache
2.1
9.8
103
541
R03AC02
ATC
salbutamol; inhalant
1.8
9.7
290
2134
N06CA01
ATC
amitriptyline and psycholeptics; systemic
3.9
9.7
29
78
ZXY01
NOMESCO Finland
Chief Physician, Head of Department or Deputy Chief Physician
56.0
9.7
11
*
M79.6
ICD-10 Finland
Pain in limb
1.9
9.7
177
1125
M03BX01
ATC
baclofen; systemic
11.7
9.6
17
15
N04BC05
ATC
pramipexole; oral
4.7
9.6
22
48
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.1
9.6
102
537
SPAT1301
SPAT
No procedures
1.9
9.5
159
981
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.3
9.4
78
371
F31
ICD-10 Finland
Bipolar affective disorder
+∞
9.4
9
*
F31.4
ICD-10 Finland
Bipolar affective disorder, current episode severe depression without psychotic symptoms
+∞
9.4
9
*
ICA03
NOMESCO Finland
Psychiatric treatment plan, outsourced psychotherapy
+∞
9.4
9
*
ICB06, ,
NOMESCO Finland
+∞
9.4
9
*
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
10.9
9.3
17
16
L28
ICPC
Limited function/disability (L)
2.7
9.3
53
212
P06
ICPC
Sleep disturbance
2.5
9.3
62
268
R25.3
ICD-10 Finland
Fasciculation
37.4
9.0
11
*
L02
ICPC
Back symptom/complaint
2.4
9.0
66
297
N05CF02
ATC
zolpidem; oral
2.7
9.0
51
203
SPAT1215
SPAT
Assessment of need for medical rehabilitation
4.3
9.0
23
55
F32
ICD-10 Finland
Depressive episode
3.9
8.9
26
69
SPAT1395
SPAT
Health check-up of persons outside student and working life
9.7
8.8
17
18
A01
ICPC
Pain general/multiple sites
2.9
8.8
41
147
E66.8
ICD-10 Finland
Other obesity
3.9
8.7
26
70
T74.1
ICD-10 Finland
Physical abuse
7.8
8.7
19
25
N05AL01
ATC
sulpiride; systemic
50.8
8.7
10
*
F33.8
ICD-10 Finland
Other recurrent depressive disorders
50.8
8.7
10
*
A28
ICPC
Limited function/disability NOS
2.8
8.6
44
166
R1250
NOMESCO Finland
Evaluation of functional capability
10.3
8.6
16
16
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.2
8.6
75
365
Z07
ICPC
Education problem
6.6
8.6
21
33
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
3.8
8.5
26
71
R5599
NOMESCO Finland
Other rehabilitation service
7.5
8.5
19
26
F42
ICD-10 Finland
Obsessive-compulsive disorder
28.0
8.5
11
*
Z63.8
ICD-10 Finland
Other specified problems related to primary support group
28.0
8.5
11
*
N05AF01
ATC
flupentixol; systemic
28.0
8.5
11
*
S18
ICPC
Laceration/cut
1.8
8.5
185
1231
C02AC02
ATC
guanfacine; oral
91.4
8.4
9
*
G24.9
ICD-10 Finland
Dystonia, unspecified
91.4
8.4
9
*
N02AX02
ATC
tramadol; systemic, rectal
1.9
8.4
122
715
IEY06
NOMESCO Finland
Psychiatric treatment and rehabilitation coaching
+∞
8.4
8
*
ZYB04
NOMESCO Finland
Outreach service in patient’s home or everyday environment
+∞
8.4
8
*
R44.3
ICD-10 Finland
Hallucinations, unspecified
+∞
8.4
8
*
IBB03
NOMESCO Finland
Assessment of vocational rehabilitation needs in a mental health context
+∞
8.4
8
*
N05AX15
ATC
cariprazine; oral
+∞
8.4
8
*
F10.00
ICD-10 Finland
Alcohol-related acute intoxication uncomplicated
+∞
8.4
8
*
F98.02
ICD-10 Finland
Non-organic nocturnal and diurnal enuresis
+∞
8.4
8
*
F91.9
ICD-10 Finland
Conduct disorder, unspecified
+∞
8.4
8
*
N05AE04
ATC
ziprasidone; systemic
+∞
8.4
8
*
C02AC01
ATC
clonidine; systemic
+∞
8.4
8
*
F41.08
ICD-10 Finland
Mild or other specified panic syndrome
+∞
8.4
8
*
D06
ICPC
Abdominal pain localized other
2.4
8.3
57
249
Z63.7
ICD-10 Finland
Other stressful life events affecting family and household
3.9
8.3
24
63
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.1
8.3
89
470
R1210
NOMESCO Finland
Medical assessment of need and possibilities to rehabilitation
14.8
8.2
13
9
P79
ICPC
Phobia/compulsive disorder
14.8
8.2
13
9
SPAT1284
SPAT
Extensive health certificate
4.5
8.2
20
46
SPAT1058
SPAT
PEF monitoring instruction
2.9
8.2
39
142
R03BB04
ATC
tiotropium bromide; inhalant
4.1
8.1
22
55
F32.1
ICD-10 Finland
Moderate depressive episode
3.2
8.1
32
104
P19
ICPC
Drug abuse
17.5
8.1
12
7
P10
ICPC
Stammering/stuttering/tic
33.9
8.1
10
*
A06AC01
ATC
ispaghula (psylla seeds); oral
2.2
8.0
71
347
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.4
8.0
59
267
R07.4
ICD-10 Finland
Chest pain, unspecified
2.0
8.0
92
498
R11
ICD-10 Finland
Nausea and vomiting
2.5
8.0
51
216
P22
ICPC
Child behaviour symptom/complaint
4.1
8.0
22
56
R13
ICD-10 Finland
Dysphagia
3.6
7.9
26
75
N06AX05
ATC
trazodone; oral
13.3
7.9
13
10
K59.09
ICD-10 Finland
Constipation, unspecified
3.4
7.9
28
85
SPAT1365
SPAT
Health check-up performed during first study year due to special need in students of upper secondary schools or vocational schools
8.6
7.9
16
19
IBA02
NOMESCO Finland
Evaluation of need for psychiatric rehabilitation
11.0
7.8
14
13
N06AG02
ATC
moclobemide; oral
11.0
7.8
14
13
SPAT1246
SPAT
Screening of depression or other psychiatric problem
2.8
7.8
40
151
P15
ICPC
Chronic alcohol abuse
9.6
7.8
15
16
XKD00
NOMESCO Finland
Uroflowmetry
2.8
7.8
38
140
ZXD10
NOMESCO Finland
Scheduled procedure
1.8
7.8
160
1043
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.2
7.8
67
324
N06AB08
ATC
fluvoxamine; oral
15.3
7.7
12
8
Z01.1
ICD-10 Finland
Examination of ears and hearing
2.1
7.7
76
387
F80.2
ICD-10 Finland
Receptive language disorder
45.7
7.7
9
*
Z01
ICPC
Poverty/financial problem
45.7
7.7
9
*
F50.1
ICD-10 Finland
Atypical anorexia nervosa
45.7
7.7
9
*
F41.3
ICD-10 Finland
Other mixed anxiety disorders
7.6
7.7
17
23
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
2.5
7.7
49
207
NA1AD
NOMESCO Finland
Cervical spine CT examination
4.1
7.7
21
53
R4120
NOMESCO Finland
Occupational therapy
3.2
7.7
30
97
P28
ICPC
Limited function/disability (P)
18.7
7.6
11
6
F41.00
ICD-10 Finland
Moderate panic disorder
18.7
7.6
11
6
A29
ICPC
General symptom/complaint other
2.3
7.6
58
266
J01FA06
ATC
roxithromycin; oral
1.8
7.6
125
761
R25.8
ICD-10 Finland
Other and unspecified abnormal involuntary movements
25.4
7.6
10
*
N01
ICPC
Headache
1.8
7.5
128
787
SPAT1310
SPAT
Counselling related to known health issue
1.7
7.5
174
1171
F10.24
ICD-10 Finland
Alcohol depence active use
81.2
7.4
8
*
R4170
NOMESCO Finland
Therapy forms involving educational rehabilitation
81.2
7.4
8
*
ICC01
NOMESCO Finland
Psychiatric treatment plan, transfer to psychiatric outpatient clinic
81.2
7.4
8
*
F44.9
ICD-10 Finland
Dissociative [conversion] disorder, unspecified
81.2
7.4
8
*
Z63.5
ICD-10 Finland
Disruption of family by separation and divorce
81.2
7.4
8
*
L03
ICPC
Low back symptom/complaint
1.8
7.4
130
808
S29
ICPC
Skin symptom/complaint other
1.9
7.4
97
549
SPAT1216
SPAT
Assessment of functional ability
2.4
7.3
49
212
ZXY83
NOMESCO Finland
Social worker in multidisciplinary team
+∞
7.3
7
*
F90.1
ICD-10 Finland
Hyperkinetic conduct disorder
+∞
7.3
7
*
ZXY49
NOMESCO Finland
Other health care provider
+∞
7.3
7
*
F93.80
ICD-10 Finland
Generalized anxiety in the bardom age
+∞
7.3
7
*
F94.9
ICD-10 Finland
Childhood disorder of social functioning, unspecified
+∞
7.3
7
*
IBC98
NOMESCO Finland
Other child protection assessment
+∞
7.3
7
*
IBB02
NOMESCO Finland
Psychiatric evaluation of working capacity and rehabilitation
+∞
7.3
7
*
IER03
NOMESCO Finland
Psychiatric disorder-specific group intervention
+∞
7.3
7
*
IBZ02
NOMESCO Finland
Somatic assessment of psychiatric patient
+∞
7.3
7
*
188
Kela drug reimbursment
Psychosis requiring demanding treatment
+∞
7.3
7
*
RS214, ,
NOMESCO Finland
+∞
7.3
7
*
ZXA00
NOMESCO Finland
Right side
2.0
7.3
82
439
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
7.3
146
942
S01
ICPC
Pain/tenderness of skin
3.4
7.2
25
75
A02BA02
ATC
ranitidine; systemic
2.5
7.2
46
195
F81.9
ICD-10 Finland
Developmental disorder of scholastic skills, unspecified
30.5
7.2
9
*
F81.0
ICD-10 Finland
Specific reading disorder
30.5
7.2
9
*
IEP01
NOMESCO Finland
Psychoeducation, family
20.3
7.2
10
5
ZXE17
NOMESCO Finland
Procedure duration 150 to 179 minutes
8.1
7.1
15
19
SPAT1234
SPAT
Support of social functional capacity
5.8
7.1
19
34
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
2.4
7.1
52
234
A05
ICPC
Feeling ill
2.0
7.1
82
443
R00.2
ICD-10 Finland
Palpitations
2.7
7.1
39
153
L17
ICPC
Foot/toe symptom/complaint
1.8
7.1
140
898
SPAT1283
SPAT
Restricted health certificate
1.7
7.1
153
1007
R32
ICD-10 Finland
Unspecified urinary incontinence
10.2
7.1
13
13
P24
ICPC
Specific learning problem
4.3
7.1
18
43
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.7
7.0
39
154
P01AB01
ATC
metronidazole; oral, rectal
1.8
6.9
137
879
G43.0
ICD-10 Finland
Migraine without aura [common migraine]
2.4
6.9
47
205
SHA02
NOMESCO Finland
Stomatognathic treatment, basic
2.5
6.9
43
180
SPAT1241
SPAT
Extensive assessment of psychosocial situation
6.2
6.8
17
28
SPAT1221
SPAT
Guidance concerning rehabilitation services and livelihood
9.5
6.8
13
14
N39.4
ICD-10 Finland
Other specified urinary incontinence
3.6
6.8
22
63
IEZ99
NOMESCO Finland
Other psychiatric rehabilitation intervention
40.6
6.8
8
*
K59.0
ICD-10 Finland
Constipation
3.0
6.7
30
105
N17
ICPC
Vertigo/dizziness
2.3
6.7
53
247
C07AB07
ATC
bisoprolol; oral
1.8
6.6
106
638
J01DB01
ATC
cefalexin; oral
1.7
6.6
408
3485
XF400
NOMESCO Finland
ECG with 12 standard connections
2.1
6.6
68
353
R96
ICPC
Asthma
2.5
6.6
42
178
R50.9
ICD-10 Finland
Fever, unspecified
1.9
6.6
92
531
G44.2
ICD-10 Finland
Tension-type headache
2.1
6.5
61
305
K30
ICD-10 Finland
Functional dyspepsia
2.4
6.5
45
198
F15.1
ICD-10 Finland
Mental and behavioural disorders due to use of other stimulants, including caffeine, harmful use
70.7
6.4
7
*
ZXY56
NOMESCO Finland
2-person team, nurse-psychologist
70.7
6.4
7
*
R4140
NOMESCO Finland
Psychotherapy
70.7
6.4
7
*
TAB00
NOMESCO Finland
Lumbar puncture
3.0
6.4
28
97
IEP02
NOMESCO Finland
Child-centred family therapy
6.7
6.4
15
23
F33
ICD-10 Finland
Recurrent depressive disorder
6.7
6.4
15
23
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.9
6.3
89
514
IGY02, ,
SPAT
18.3
6.3
9
5
F40.8
ICD-10 Finland
Other phobic anxiety disorders
18.3
6.3
9
5
N02BF01
ATC
gabapentin; oral
3.1
6.3
25
82
IAB07
NOMESCO Finland
Consultation concerning a patient with self-harm intention
+∞
6.3
6
*
IBZ08
NOMESCO Finland
Gender identity assessment
+∞
6.3
6
*
RT230, ,
NOMESCO Finland
+∞
6.3
6
*
N05AE05
ATC
lurasidone; oral
+∞
6.3
6
*
N05AX16
ATC
brexpiprazole; oral
+∞
6.3
6
*
X84
ICD-10 Finland
Intentional self-harm by unspecified means
+∞
6.3
6
*
F22.0
ICD-10 Finland
Delusional disorder
+∞
6.3
6
*
F64.0
ICD-10 Finland
Transsexualism
+∞
6.3
6
*
F34.9
ICD-10 Finland
Persistent mood [affective] disorder, unspecified
+∞
6.3
6
*
Z61.2
ICD-10 Finland
Altered pattern of family relationships in childhood
+∞
6.3
6
*
N05AF05
ATC
zuclopenthixol; systemic
+∞
6.3
6
*
IBZ07
NOMESCO Finland
Neurological assessment in psychiatry
+∞
6.3
6
*
ZXY57
NOMESCO Finland
2-person team, nurse-social worker
+∞
6.3
6
*
F20.09
ICD-10 Finland
Paranoid schizophrenia UNS
+∞
6.3
6
*
F31.20
ICD-10 Finland
Bipolar disorder, manic episode with mood-congruent psychotic symptoms
+∞
6.3
6
*
IDP99
NOMESCO Finland
Other psychotherapeutic family intervention
+∞
6.3
6
*
F54
ICD-10 Finland
Psychological and behavioural factors associated with disorders or diseases classified elsewhere
+∞
6.3
6
*
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
2.4
6.2
44
195
SPAT1254
SPAT
Administration of medicine
1.8
6.2
98
587
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.1
6.2
26
88
TLC00
NOMESCO Finland
Insertion of intrauterine device
2.9
6.2
28
99
S04
ICPC
Lump/swelling localized
2.0
6.2
66
347
Z09.4
ICD-10 Finland
Follow-up examination after treatment of fracture
2.9
6.2
29
105
K96
ICPC
Haemorrhoids
3.7
6.1
19
53
ZXE00
NOMESCO Finland
One hour or less
1.6
6.1
173
1217
X44
ICD-10 Finland
Accidental poisoning by and exposure to other and unspecified drugs, medicaments and biological substances
10.2
6.1
11
11
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.9
6.0
77
431

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
78
43
21.07
99.47
2.5
1.7
—
—
—
0
0
185
727
3.36
36.40
2.7
3.0
2.37
2.37
mmol/l
0.13
163
653
83
188
5.04
35.23
3.2
1.4
—
—
—
0
0
412
2699
3.30
30.90
4.3
3.3
14.46
14.64
pmol/l
0.81
378
2434
181
774
3.02
30.00
1.9
1.5
100.08
98.52
pmol/l
0.18
100
392
237
1216
2.71
27.33
2.6
2.5
68.27
72.43
nmol/l
1.53
228
1132
348
2171
2.73
26.78
7.0
6.1
87.36
85.81
u/l
0.19
329
2049
90
271
3.79
26.05
2.3
1.3
—
—
—
0
0
240
1282
2.58
24.96
7.7
6.9
1.22
1.22
mmol/l
0.09
210
1117
298
1772
2.54
24.54
3.2
2.5
—
—
—
0
0
113
416
3.18
23.76
1.6
1.3
18.46
21.09
nmol/l
1.33
102
368
446
3270
3.21
23.42
5.2
3.6
1.88
1.85
mu/l
0.23
425
3041
462
3471
3.46
22.95
14.1
8.9
139.52
139.52
mmol/l
0.02
456
3334
140
602
2.80
22.13
2.9
2.0
167.58
444.44
u/l
1.43
132
567
410
2913
2.75
22.10
3.8
2.7
5.62
5.56
mmol/l
0.45
388
2678
461
3486
3.36
22.08
14.2
8.9
3.92
3.93
mmol/l
0.34
453
3338
81
254
3.58
21.93
1.7
1.7
1090.01
1118.11
nmol/l
0.10
66
196
101
364
3.19
21.90
2.2
1.3
—
—
—
0
0
234
1295
2.44
21.84
5.9
6.0
11.24
12.29
umol/l
0.39
222
1205
162
759
2.63
21.55
3.6
3.6
9.00
8.85
mmol/l
0.10
142
692
317
2046
2.35
20.31
7.4
7.0
0.19
0.19
e9/l
0.25
278
1810
104
398
3.00
20.24
2.2
1.3
—
—
—
0
0
215
1185
2.36
19.82
6.7
7.0
1.22
1.22
mmol/l
0.10
201
1104
99
374
3.02
19.68
1.6
1.6
445.58
20489733.45
pmol/l
0.50
85
327
104
405
2.95
19.58
2.2
1.3
—
—
—
0
0
104
407
2.93
19.39
2.3
1.3
—
—
—
0
0
305
1967
2.28
19.16
6.8
6.9
0.04
0.04
e9/l
0.04
261
1708
305
1971
2.28
19.01
6.8
6.8
0.55
0.54
e9/l
0.51
261
1714
102
405
2.88
18.47
1.9
1.3
—
—
—
0
0
293
1884
2.23
18.21
6.7
7.2
—
—
—
0
0
194
1058
2.31
17.98
4.8
5.7
37.93
37.42
g/l
0.60
183
996
314
2086
2.23
17.87
6.7
6.7
2.03
2.03
e9/l
0.00
275
1864
355
2498
2.26
17.25
4.4
3.6
8.91
7.96
mm/h
0.69
328
2306
97
402
2.73
16.07
5.9
6.5
0.85
0.83
mmol/l
0.66
90
384
288
1902
2.12
15.98
7.1
7.1
8.53
8.27
%
0.85
274
1809
153
791
2.31
15.77
2.7
2.2
51.94
56.86
u/l
0.56
143
736
343
2435
2.14
15.54
4.1
2.7
30.71
32.57
u/l
0.39
325
2329
322
2233
2.11
15.51
10.5
8.3
3.74
3.79
e9/l
0.17
281
1918
284
1887
2.08
15.26
7.0
7.0
2.89
2.96
%
0.17
268
1790
299
2026
2.08
15.21
6.9
6.8
31.69
31.97
%
0.17
286
1936
277
1827
2.07
15.14
7.0
7.1
0.65
0.66
%
0.18
262
1728
29
54
5.62
15.11
2.0
1.1
—
—
—
0
0
138
696
2.33
14.98
2.9
3.0
1.02
1.02
kg/l
0.04
14
128
21
10
21.79
14.76
1.7
1.1
—
—
—
0
0
291
1991
2.01
13.98
6.8
6.6
53.07
53.70
%
0.39
279
1900
262
1789
1.91
12.05
4.4
4.2
6.20
6.35
mmol/l
0.61
237
1599
475
4017
2.65
11.83
10.5
7.3
27.53
26.96
u/l
0.25
465
3877
125
663
2.16
11.72
3.7
4.2
7.38
7.40
ph
2.09
22
135
258
1771
1.88
11.51
3.1
2.7
75.35
76.43
ug/l
0.05
242
1676
137
760
2.08
11.39
2.9
2.8
2.72
2.74
mg/l
0.05
119
667
140
796
2.03
10.82
3.6
2.6
30.74
44.50
ng/l
0.35
71
373
109
566
2.16
10.71
3.4
2.7
—
—
—
0
0
48
170
3.00
10.52
6.1
3.0
—
—
—
0
0
212
1398
1.86
10.47
3.0
2.7
6.25
5.98
ph
0.89
12
160
72
317
2.47
10.37
2.9
2.8
2.42
2.42
mmol/l
0.08
66
270
261
1855
1.80
9.93
9.8
8.8
0.00
0.00
e9/l
0.54
207
1482
59
241
2.63
9.92
2.1
2.2
182.24
37.80
u/l
0.45
49
206
114
619
2.07
9.91
5.1
3.7
—
—
—
0
0
158
964
1.91
9.83
8.7
7.5
—
—
—
0
0
304
2272
1.78
9.64
4.6
3.4
6074.80
700.64
e6/l
—
5
36
25
64
4.05
8.97
1.2
1.1
—
—
—
0
0
108
614
1.95
8.14
2.8
2.6
552.43
585.59
mosm/kgh2o
0.58
89
536
389
3209
1.78
7.98
3.5
3.0
4.48
4.59
mmol/l
1.34
373
3066
333
2632
1.70
7.96
4.4
3.6
36.88
37.62
mmol/mol
0.70
317
2504
186
1261
1.73
7.88
1.5
1.5
0.59
1.64
u/ml
2.78
43
288
386
3184
1.77
7.84
3.4
2.9
1.38
1.43
mmol/l
1.57
365
3032
22
57
3.98
7.77
1.1
1.1
—
—
—
0
0
389
3219
1.77
7.77
3.7
3.1
2.74
2.78
mmol/l
0.44
370
3048
154
996
1.77
7.67
3.4
3.0
29.30
69.82
e6/l
0.64
121
739
318
2503
1.67
7.53
4.4
3.5
—
—
—
0
0
159
1050
1.73
7.31
5.6
8.6
1.09
1.15
inr
0.70
56
352
7
0
+∞
7.31
3.7
0.0
118.14
—
nmol/l
—
7
0
49
215
2.41
7.10
5.4
8.0
1.48
1.50
mmol/l
0.02
49
210
67
337
2.13
7.03
4.1
4.8
8.38
7.01
umol/l
0.14
58
282
73
381
2.06
6.95
2.1
1.5
—
—
—
0
0
139
900
1.74
6.79
3.4
2.9
0.31
0.29
e6/l
0.06
107
664
24
73
3.40
6.77
1.2
2.6
—
—
—
0
0
63
315
2.13
6.71
1.8
2.8
10.57
10.08
g/l
0.62
57
291
458
4048
1.92
6.56
14.2
8.8
19.04
22.25
mg/l
1.63
346
2895
77
422
1.96
6.40
7.2
7.9
1.13
1.20
mmol/l
1.30
71
400
365
3047
1.63
6.23
3.3
2.8
1.22
1.17
mmol/l
0.65
345
2894
175
1232
1.63
6.14
4.0
3.4
18.31
42.50
e6/l
2.30
128
801
165
1146
1.64
6.11
1.5
1.5
1.88
1.91
g/l
0.11
93
673
138
918
1.68
6.03
3.2
2.8
—
—
—
0
0
79
446
1.91
6.01
1.3
1.2
—
—
—
0
0
109
684
1.75
5.88
1.7
1.7
1.53
1.29
mmol/l
1.34
93
608
105
663
1.73
5.52
2.4
2.7
10.43
8.12
e6/l
0.45
89
598
230
1769
1.53
5.32
4.8
4.0
0.00
0.00
estimate
-0.00
47
360
105
673
1.70
5.21
3.0
2.6
1.17
0.91
mg/l
0.48
68
469
231
1788
1.51
5.14
3.6
2.9
0.00
0.00
estimate
-0.00
45
340
84
511
1.76
5.01
3.5
2.6
2.04
2.05
e6/l
0.01
54
274
512
4802
2.61
4.95
21.1
12.3
40.63
41.68
%
0.53
487
4575
12
20
6.11
4.93
1.4
1.8
—
—
—
0
0
81
491
1.77
4.89
1.4
1.2
17.92
20.27
iu/ml
0.11
18
155
424
3756
1.63
4.88
17.6
10.9
13.83
13.76
%
0.14
419
3692
26
101
2.65
4.88
2.2
2.4
—
—
—
0
0
58
317
1.93
4.86
1.3
1.3
235.83
290.30
u/ml
0.36
53
288
512
4809
2.57
4.80
21.0
12.1
88.29
88.20
fl
0.17
506
4747
512
4809
2.57
4.80
21.0
12.1
29.56
29.62
pg
0.34
506
4746
67
386
1.84
4.78
4.2
6.9
1.96
1.43
mmol/l
1.01
54
312
512
4810
2.56
4.78
21.1
12.2
6.72
6.62
e9/l
0.58
494
4646
512
4810
2.56
4.78
21.0
12.2
4.66
4.65
e12/l
0.09
494
4644
36
165
2.27
4.77
2.5
3.6
—
—
—
0
0
466
4241
1.78
4.72
12.5
7.4
—
—
—
0
0
511
4800
2.50
4.70
21.1
12.2
261.26
257.06
e9/l
0.80
496
4640
512
4817
2.53
4.63
21.2
12.3
137.13
137.31
g/l
0.10
506
4756
112
754
1.61
4.56
3.0
2.8
—
—
—
0
0
42
209
2.10
4.56
2.9
3.5
79.28
62.73
e9/l
0.87
30
127
18
60
3.07
4.44
2.0
3.9
—
—
—
0
0
225
1771
1.47
4.43
3.4
2.9
0.00
0.00
estimate
0.50
45
361
61
351
1.83
4.38
6.7
8.8
—
—
—
0
0
32
640
0.47
4.34
1.3
1.2
—
—
—
0
0
56
316
1.86
4.27
1.2
1.3
—
—
—
0
0
37
180
2.13
4.26
1.6
1.4
—
—
—
0
0
35
168
2.16
4.17
1.5
1.2
—
—
—
0
0
10
17
5.97
4.14
3.0
6.4
15.89
24.00
ug/l
—
10
17
56
322
1.83
4.03
5.9
5.6
5.18
5.04
kpa
0.84
50
307
54
307
1.84
4.03
1.2
1.2
134.89
135.67
iu/ml
0.01
17
108
77
486
1.68
4.02
1.5
1.5
301.82
507.57
titre
1.48
11
103
114
796
1.55
3.95
2.8
2.2
—
—
—
0
0
34
166
2.12
3.90
3.7
5.4
1.22
1.23
mmol/l
0.19
27
151
10
19
5.34
3.84
1.5
2.4
—
—
—
0
0
16
55
2.97
3.76
1.7
1.3
317.57
342.10
ug/g
—
7
33
20
80
2.56
3.58
1.3
3.9
—
—
—
0
0
78
510
1.62
3.56
3.3
3.4
2517.54
69.51
mg/l
1.07
53
367
153
1161
1.45
3.50
1.8
1.8
—
—
—
0
0
46
263
1.82
3.40
6.5
7.6
105.70
104.59
mmol/l
0.91
46
263
124
914
1.46
3.28
3.3
3.1
0.00
0.01
estimate
0.88
45
345
57
352
1.69
3.24
3.8
2.5
2444.49
4630.20
u/l
0.48
20
153
70
457
1.61
3.22
3.1
2.7
275.45
1107.18
ng/l
1.60
31
276
79
534
1.56
3.14
3.8
3.9
12.19
9.78
mg/mmol
0.15
51
380
71
468
1.60
3.14
1.4
1.2
10.81
7.75
u/ml
0.16
26
184
185
1476
1.39
3.13
2.7
2.0
—
—
—
0
0
7
13
5.44
2.87
1.7
1.2
—
—
—
0
0
13
47
2.81
2.83
1.2
3.9
—
—
—
0
0
17
72
2.41
2.75
1.6
1.5
—
—
—
0
0
8
19
4.26
2.68
1.0
1.4
—
—
—
0
0
9
24
3.80
2.68
1.1
1.1
256.11
286.89
mg/l
—
9
19
56
363
1.61
2.67
2.7
1.8
—
—
—
0
0
12
41
2.97
2.63
1.2
1.2
—
—
—
0
0
39
231
1.74
2.60
1.2
1.2
—
—
—
0
0
92
670
1.45
2.57
1.9
1.5
—
—
—
0
0
96
707
1.44
2.53
3.2
3.3
147.95
130.48
ug/g
0.19
74
568
7
16
4.42
2.48
8.4
5.6
—
—
—
0
0
6
12
5.04
2.41
1.2
1.4
—
—
—
0
0
41
255
1.66
2.32
7.7
4.5
0.93
0.83
%
0.12
15
82
40
249
1.66
2.26
1.5
1.3
175.29
261.77
miu/ml
0.80
14
136
38
235
1.66
2.20
7.2
4.2
0.54
0.41
%
0.21
13
69
22
115
1.95
2.19
1.3
1.3
—
—
—
0
0
39
245
1.64
2.14
7.9
4.5
0.23
0.08
%
0.57
13
72
40
254
1.62
2.11
1.1
1.2
2.88
2.33
u/ml
0.14
28
171
14
62
2.29
2.09
3.1
6.1
3.90
2.52
mmol/l
—
7
30
11
43
2.59
2.09
1.2
2.8
12.82
11.09
%
0.21
11
43
5
10
5.04
2.07
1.0
1.1
148.13
169.18
mmol/24h
—
5
10
7
20
3.53
2.06
1.1
1.3
—
—
—
0
0
47
315
1.54
1.99
1.6
1.5
—
—
—
0
0
42
277
1.56
1.91
7.3
5.9
—
—
—
0
0
33
205
1.65
1.91
1.1
1.2
—
—
—
0
0
23
129
1.82
1.88
1.5
1.7
—
—
—
0
0
8
28
2.88
1.87
1.5
4.0
—
—
—
0
0
36
232
1.59
1.81
1.1
1.2
3.96
6.58
u/ml
0.87
26
171
21
117
1.83
1.77
1.0
1.1
—
—
—
0
0
33
210
1.61
1.75
1.2
1.2
2.57
2.04
u/ml
0.13
24
148
28
171
1.67
1.74
1.3
1.6
325.57
190.21
u/ml
0.96
14
90
7
24
2.94
1.72
1.3
1.3
—
—
—
0
0
16
82
1.98
1.71
2.7
3.1
—
—
—
0
0
25
149
1.71
1.70
3.2
4.8
6.51
5.27
ug/l
0.12
20
119
10
41
2.47
1.65
1.6
9.2
—
—
—
0
0
36
238
1.55
1.65
8.5
4.6
0.00
0.09
%
—
10
65
7
26
2.71
1.58
1.7
2.3
32.57
32.58
pg
—
7
26
7
26
2.71
1.58
1.6
4.0
—
—
—
0
0
23
137
1.71
1.58
1.0
1.1
4.22
7.56
u/ml
0.79
15
86
17
92
1.88
1.57
1.5
1.6
—
—
—
0
0
19
108
1.79
1.52
11.3
8.1
—
—
—
0
0
6
21
2.88
1.51
1.3
1.2
338.00
188.95
iu/ml
—
6
21
79
997
0.76
1.50
1.7
1.6
—
—
—
0
0
32
211
1.55
1.49
8.1
6.8
0.84
0.74
mmol/l
0.08
25
170
35
236
1.52
1.48
1.7
1.7
10.08
13.50
iu/l
0.58
25
178
34
228
1.52
1.48
1.1
1.2
0.69
1.18
u/ml
0.40
22
148
20
117
1.74
1.47
1.0
1.1
—
—
—
0
0
9
38
2.39
1.46
1.7
1.5
—
—
—
0
0
11
52
2.14
1.45
1.3
1.1
3.05
15.87
u/ml
—
5
38
5
16
3.14
1.44
3.4
3.0
2.04
2.64
nmol/l
—
5
16
9
39
2.33
1.43
2.1
3.2
8.00
14.69
%
—
9
39
32
214
1.53
1.42
1.3
1.5
—
—
—
0
0
9
41
2.22
1.37
1.1
1.1
—
—
—
0
0
42
300
1.43
1.36
2.4
1.9
12.77
13.34
nmol/l
0.10
36
282
10
47
2.15
1.34
1.6
2.7
40.89
37.77
%
—
10
47
29
194
1.52
1.29
3.6
2.1
—
—
—
0
0
8
34
2.37
1.29
1.1
2.8
33.25
25.29
%
—
8
34
12
62
1.96
1.28
2.3
6.8
—
—
—
0
0
22
138
1.62
1.28
1.8
1.7
—
—
—
0
0
14
77
1.84
1.26
3.2
2.1
—
—
—
0
0
17
100
1.72
1.25
2.2
6.0
0.70
0.69
%
0.05
17
100
19
117
1.65
1.19
5.2
2.6
—
—
—
0
0
132
1133
1.22
1.16
1.9
1.7
—
—
—
0
0
24
161
1.51
1.08
9.6
7.6
121.38
123.69
g/l
0.24
24
155
7
32
2.20
1.08
4.6
3.4
1.90
1.68
umol/l
—
7
32
11
59
1.88
1.08
1.5
7.4
—
—
—
0
0
20
130
1.56
1.04
1.1
1.1
1.66
8.77
u/ml
2.91
12
73
5
22
2.28
1.03
2.0
1.2
73.60
76.73
umol/l
—
5
22
13
75
1.75
1.03
1.5
1.3
—
4.66
—
0
8
54
424
1.30
1.02
1.6
1.5
—
—
—
0
0
20
132
1.54
0.98
1.3
1.6
35.40
38.21
nmol/l
0.24
20
132
30
216
1.41
0.98
1.6
1.8
5.48
7.25
u/l
0.88
23
157
0
30
0.00
0.97
0.0
2.7
—
21.27
—
0
30
10
54
1.87
0.97
1.0
5.2
—
—
—
0
0
46
356
1.32
0.97
1.4
1.4
—
—
—
0
0
22
149
1.50
0.97
3.6
3.3
87.33
148.51
ng/l
0.86
15
131
47
366
1.31
0.95
2.1
1.5
—
—
—
0
0
6
27
2.24
0.93
4.3
2.1
—
—
—
0
0
13
78
1.68
0.92
1.3
1.5
—
—
—
0
0
52
415
1.28
0.89
1.6
1.4
—
—
—
0
0
6
30
2.01
0.87
1.5
1.3
—
—
—
0
0
122
1070
1.18
0.86
3.3
2.6
—
—
—
0
0
6
31
1.95
0.84
1.0
1.4
—
—
nmol/l
—
0
0
6
31
1.95
0.84
1.8
1.0
—
—
—
0
0
19
129
1.49
0.84
10.9
8.8
95.23
95.93
%
0.55
19
129
6
32
1.88
0.82
1.8
1.3
—
—
—
0
0
0
24
0.00
0.79
0.0
3.0
—
2.06
—
0
24
70
588
1.22
0.79
4.6
3.1
319.65
4411.11
umol/l
1.75
65
541
17
115
1.49
0.77
1.5
1.7
—
80.00
—
0
14
6
34
1.77
0.76
1.8
1.3
—
—
—
0
0
9
54
1.68
0.75
1.9
3.8
1.59
1.36
mmol/l
—
9
54
5
24
2.09
0.74
2.4
3.6
741.40
576.96
u/ml
—
5
24
5
25
2.01
0.73
6.4
4.0
23.60
25.51
umol/l
—
5
25
7
39
1.81
0.72
1.4
1.1
—
—
—
0
0
5
26
1.93
0.71
1.2
2.4
37.54
15.69
umol/l
—
5
26
7
41
1.72
0.70
1.1
1.6
4.80
2.30
u/ml
—
7
41
7
42
1.68
0.68
2.1
4.9
—
—
—
0
0
5
27
1.86
0.68
1.4
1.3
—
—
—
0
0
115
1025
1.16
0.67
2.6
2.3
—
—
—
0
0
11
70
1.58
0.65
1.3
1.1
—
—
—
0
0
46
378
1.24
0.65
1.8
2.0
—
—
—
0
0
7
44
1.60
0.65
10.1
3.5
—
—
—
0
0
5
29
1.73
0.64
1.0
1.1
2967.60
1674.41
miu/ml
—
5
29
121
1339
0.88
0.62
2.2
2.0
—
—
—
0
0
5
30
1.67
0.61
3.8
2.0
91.52
91.44
%
—
5
30
18
131
1.39
0.60
11.3
8.7
0.53
0.68
%
1.34
18
131
17
123
1.39
0.58
1.0
1.1
0.13
0.52
u/ml
—
8
52
6
36
1.67
0.57
2.0
1.6
285.33
294.70
mosm/kgh2o
—
6
27
28
350
0.79
0.56
1.2
1.3
—
—
—
0
0
10
65
1.55
0.56
1.2
1.3
—
—
—
0
0
18
133
1.37
0.55
1.9
1.6
—
—
—
0
0
16
116
1.39
0.55
1.1
1.2
—
—
—
0
0
6
38
1.59
0.54
1.0
1.3
—
—
—
0
0
6
38
1.59
0.54
4.0
1.8
2.20
1.57
mmol/l
—
6
38
16
117
1.38
0.53
1.1
1.1
—
—
—
0
0
16
117
1.38
0.53
1.2
1.1
—
—
—
0
0
14
100
1.41
0.52
2.7
1.9
3.05
7.18
iu/l
—
6
40
9
64
1.41
0.51
1.2
1.1
—
—
—
0
0
58
502
1.17
0.51
3.6
3.4
1.63
2.31
ug/l
0.44
52
461
13
92
1.42
0.51
3.8
4.0
—
—
—
0
0
129
1402
0.89
0.50
1.6
1.7
—
—
—
0
0
10
68
1.48
0.47
2.4
2.6
—
—
—
0
0
12
86
1.40
0.45
1.8
1.6
—
—
—
0
0
18
230
0.78
0.44
1.9
1.4
—
—
—
0
0
26
211
1.24
0.44
1.1
1.1
—
—
—
0
0
5
32
1.57
0.42
2.2
1.6
—
—
—
0
0
5
34
1.47
0.40
5.8
5.6
1.87
1.68
ug/l
—
5
34
5
35
1.43
0.39
1.0
1.1
—
—
—
0
0
14
107
1.32
0.37
1.1
1.1
—
—
—
0
0
5
37
1.35
0.37
1.6
10.1
11.24
12.02
%
—
5
37
169
1601
1.08
0.34
2.7
2.5
—
—
—
0
0
25
209
1.21
0.34
1.9
1.7
3.38
5.70
e9/l
0.89
20
191
12
91
1.33
0.34
4.3
6.2
24.99
24.04
mmol/l
0.59
12
83
12
91
1.33
0.34
13.5
7.3
—
—
—
0
0
6
47
1.28
0.32
1.0
1.0
—
—
—
0
0
38
335
1.14
0.30
3.4
3.2
—
—
—
0
0
7
55
1.28
0.30
1.0
1.3
26.96
12.88
u/l
—
7
50
17
144
1.19
0.22
5.2
6.3
0.42
0.24
g/l
—
10
85
0
11
0.00
0.21
0.0
2.0
—
—
—
0
0
0
11
0.00
0.21
0.0
7.2
—
31.00
—
0
11
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
3.2
—
—
—
0
0
22
193
1.15
0.20
1.5
1.5
—
—
—
0
0
6
50
1.20
0.19
1.0
1.4
—
—
—
0
0
6
53
1.13
0.18
1.0
1.1
—
—
—
0
0
7
60
1.17
0.18
1.0
1.5
—
—
—
0
0
8
70
1.14
0.16
2.1
1.7
1.39
6.18
ug/l
—
8
57
6
80
0.75
0.15
2.7
2.2
25.98
14.75
mu/l
—
6
75
22
198
1.12
0.14
1.6
1.5
—
—
—
0
0
104
1002
1.05
0.14
2.1
1.8
—
—
—
0
0
17
152
1.12
0.12
1.2
1.2
—
—
—
0
0
28
300
0.93
0.10
3.1
2.3
0.62
0.76
ug/l
0.42
16
142
5
46
1.09
0.09
1.8
1.4
—
—
—
0
0
36
340
1.06
0.09
1.1
1.2
—
—
—
0
0
21
194
1.09
0.09
1.5
1.5
—
—
—
0
0
12
113
1.06
0.02
1.2
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
3.46
—
0
9
0
7
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
275.00
—
0
7
7
69
1.01
-0.00
1.1
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
4.3
—
1.18
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
33.40
—
0
5
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
2.14
—
0
5
5
50
1.00
-0.00
1.6
1.7
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint KRA_PSY_TIC_EXMORE and mortality.

Females

Parameter HR [95% CI] p-value
KRA_PSY_TIC_EXMORE 1.34 [0.94, 1.92] 0.111
Birth year 0.994 [0.99, 1.0] 0.182

During the follow-up period (1.1.1998 — 31.12.2019), 63 out of 2389 females with KRA_PSY_TIC_EXMORE died.

Males

Parameter HR [95% CI] p-value
KRA_PSY_TIC_EXMORE 1.569 [1.19, 2.07] 0.001
Birth year 0.99 [0.98, 1.0] 0.03

During the follow-up period (1.1.1998 — 31.12.2019), 92 out of 6900 males with KRA_PSY_TIC_EXMORE died.

Mortality risk

Mortality risk for people of age

years, who have KRA_PSY_TIC_EXMORE.

N-year risk Females Males
1 0.136% 0.294%
5 0.77% 1.889%
10 1.82% 4.912%
15 3.571% 9.327%
20 6.152% 15.684%

Relationships between endpoints

↥

Index endpoint: KRA_PSY_TIC_EXMORE – Tic and related disorders

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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