Tic and related disorders

KRA_PSY_TIC_EXMORE

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

-

2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 F95
  • Hospital discharge: ICD-9 3072
  • Hospital discharge: ICD-8 30620
  • Cause of death: ICD-10 F95
  • Cause of death: ICD-9 3072
  • Cause of death: ICD-8 30620

2 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

None

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Control exclude
KRA_PSY_ANYMENTAL

Extra metadata

First used in FinnGen datafreeze
DF12
Parent code in ICD-10
F90-F98
Name in latin
Perturbationes ticiformes

Case counts by codes

FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 12184 3427 8742
Only index persons 9944 2898 7046
Unadjusted period prevalence (%)
Whole population 0.20 0.10 0.24
Only index persons 0.22 0.11 0.27
Median age at first event (years)
Whole population 9.93 10.84 9.52
Only index persons 10.81 12.11 10.28

-FinnGen-

Key figures

All Female Male
Number of individuals 513 261 252
Unadjusted period prevalence (%) 0.10 0.09 0.11
Median age at first event (years) 14.66 17.04 12.20

-FinRegistry-

Age distribution of first events

01020304050607080900.0k0.5k1.0k1.5k2.0k2.5k3.0k3.5k4.0k4.5k5.0k5.5k6.0kAgeIndividuals

-FinnGen-

Age distribution of first events

0102030405060708090020406080100120140160AgeIndividuals

-FinRegistry-

Year distribution of first events

197519801985199019952000200520102015202020220.0k0.2k0.4k0.6k0.8k1.0k1.2k1.4k1.6k1.8k2.0k2.2k2.4k2.6k2.8k3.0kYearIndividuals

-FinnGen-

Year distribution of first events

197519801985199019952000200520102015202020230102030405060708090YearIndividuals

-FinRegistry-

Cumulative Incidence Function

01020304050607080901000.00.10.20.30.40.50.60.70.80.91.0AgeProbability of first incidence (%)

-FinnGen-

Cumulative Incidence Function

01020304050607080901000.00.10.20.30.40.50.60.70.80.91.0AgeProbability of first incidence (%)

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
448
Matched controls
4480
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
F95.9
ICD-10 Finland
Tic disorder, unspecified
2334.8
170.2
154
*
F95.2
ICD-10 Finland
Combined vocal and multiple motor tic disorder [de la Tourette]
+∞
163.9
147
*
N05AX08
ATC
risperidone; systemic
161.4
116.7
119
10
F95.0
ICD-10 Finland
Transient tic disorder
+∞
106.6
98
*
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
17.2
88.8
149
126
N05AH04
ATC
quetiapine; oral
22.0
88.6
134
85
N05AX12
ATC
aripiprazole; systemic
998.2
86.6
82
*
F95.1
ICD-10 Finland
Chronic motor or vocal tic disorder
895.6
78.9
75
*
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
375.6
65.3
64
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
24.7
64.8
93
47
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
361.5
63.1
62
*
F90.0
ICD-10 Finland
Disturbance of activity and attention
34.0
60.5
79
28
N05AH03
ATC
olanzapine; systemic
135.5
56.3
59
5
N05BA04
ATC
oxazepam; oral
8.7
55.0
130
200
N06AB06
ATC
sertraline; oral
14.4
54.0
95
82
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
583.8
53.7
52
*
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
12.5
53.5
101
102
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
26.6
51.7
72
32
N06AB03
ATC
fluoxetine; oral
17.5
49.7
80
55
N06BA04
ATC
methylphenidate; oral
30.9
48.0
64
24
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
97.9
48.0
52
6
N05AD01
ATC
haloperidol; systemic
114.8
47.9
51
5
F29
ICD-10 Finland
Unspecified nonorganic psychosis
483.5
45.1
44
*
N06AX16
ATC
venlafaxine; oral
12.2
44.0
83
82
IBZ01
NOMESCO Finland
Profession-specific psychiatric evaluation
237.2
42.7
43
*
N03AE01
ATC
clonazepam; systemic
24.5
40.9
58
27
N03AX09
ATC
lamotrigine; oral
82.9
40.7
45
6
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
+∞
40.2
38
*
IGY99
NOMESCO Finland
Other psychiatric treatment contact
63.8
40.1
46
8
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
51.1
38.7
46
10
IBA04
NOMESCO Finland
Extensive initial psychiatric evaluation
142.0
37.3
39
*
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
47.4
35.7
43
10
N06AB10
ATC
escitalopram; oral
5.3
32.8
111
261
IGP01
NOMESCO Finland
Psychiatric family contact
91.8
31.2
34
*
IBA01
NOMESCO Finland
Diagnostic and symptom-mapping evaluation
171.9
31.1
32
*
N06AX12
ATC
bupropion; oral
14.9
30.9
52
39
N06AX11
ATC
mirtazapine; oral
4.6
30.5
119
324
T36
ICD-10 Finland
Poisoning by systemic antibiotics
40.1
29.8
37
10
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
+∞
28.4
27
*
IFA01
NOMESCO Finland
Psychiatric pharmacotherapy plan, not specified
+∞
28.4
27
*
IGV01
NOMESCO Finland
Psychiatric network contact
299.3
28.1
28
*
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
6.7
27.5
74
129
F93.89
ICD-10 Finland
Other childhood emotional disorders
+∞
27.4
26
*
30620
ICD-8 Finland
Special symptoms not elsewhere classified, Tics
+∞
27.4
26
*
F83
ICD-10 Finland
Mixed specific developmental disorders
+∞
27.4
26
*
N05BA01
ATC
diazepam; systemic, rectal
7.5
27.2
67
103
IGY02
NOMESCO Finland
Psychiatric monitoring contact
30.0
27.1
36
13
N06AB04
ATC
citalopram; systemic
6.1
27.0
78
149
F42.2
ICD-10 Finland
Mixed obsessional thoughts and acts
103.2
27.0
29
*
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
49.0
26.8
32
7
N03AG01
ATC
valproic acid; systemic, rectal
13.3
26.7
47
39
ICC04
NOMESCO Finland
Psychiatric treatment plan, permanent discontinuation
77.1
26.1
29
*
F84.5
ICD-10 Finland
Asperger syndrome
275.7
26.0
26
*
F95.8
ICD-10 Finland
Other tic disorders
+∞
25.2
24
*
ICB03
NOMESCO Finland
Psychiatric treatment plan, monitoring
264.1
24.9
25
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
6.4
23.8
65
115
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
68.8
23.1
26
*
331
Kela drug reimbursment
Atomoxetine, dexamphetamine, guanfacine and lisdexamphetamine
88.1
22.9
25
*
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
+∞
22.1
21
*
F80.1
ICD-10 Finland
Expressive language disorder
+∞
22.1
21
*
F42.9
ICD-10 Finland
Obsessive-compulsive disorder, unspecified
84.4
21.9
24
*
F32.00
ICD-10 Finland
Mild depressive episode without somatic syndrome
17.4
21.8
34
21
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
31.8
20.8
27
9
IBZ06
NOMESCO Finland
Evaluation concerning developmental neuropsychiatry
115.4
20.8
22
*
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
+∞
19.9
19
*
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
6.1
18.5
52
95
Z03.2
ICD-10 Finland
Observation for suspected mental and behavioural disorders
28.1
18.0
24
9
ICB02
NOMESCO Finland
Psychiatric treatment plan, extended/prolonged
+∞
17.8
17
*
N06BA09
ATC
atomoxetine; oral
187.1
17.6
18
*
IEV99
NOMESCO Finland
Other psychiatric network intervention
187.1
17.6
18
*
N06AB05
ATC
paroxetine; oral
13.4
16.9
29
23
F31.8
ICD-10 Finland
Other bipolar affective disorders
+∞
16.8
16
*
3072A
ICD-9 Finland
Special symptoms or syndromes not elsewhere classified, Tics[NYKIMISHÄIRIÖ, MÄÄRITTELEMÄTÖN]
+∞
16.8
16
*
SPAT1240
SPAT
Therapeutic discussion
3.6
16.7
83
269
N05CF01
ATC
zopiclone; oral
3.5
16.7
84
276
N04AA02
ATC
biperiden; systemic
176.3
16.6
17
*
F41.8
ICD-10 Finland
Other specified anxiety disorders
12.8
16.6
29
24
N06AX26
ATC
vortioxetine; oral
8.9
16.6
35
42
C07AA05
ATC
propranolol; systemic
3.4
16.5
89
306
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
14.3
16.2
27
20
F33.00
ICD-10 Finland
Recurrent depression, mild episode without somatic syndrome
62.3
15.9
18
*
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
+∞
15.7
15
*
N05AH02
ATC
clozapine; systemic
+∞
15.7
15
*
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
13.7
15.4
26
20
N06AX21
ATC
duloxetine; oral
6.7
15.3
39
63
XA800
NOMESCO Finland
Neuropsychological investigation
7.4
15.2
36
52
F41.1
ICD-10 Finland
Generalized anxiety disorder
9.4
15.2
31
35
F42.1
ICD-10 Finland
Predominantly compulsive acts [obsessional rituals]
46.7
15.2
18
*
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
15.8
15.0
24
16
SPAT1243
SPAT
Psychiatric/psychological examination
6.7
14.9
38
61
N05AA02
ATC
levomepromazine; systemic
58.7
14.9
17
*
F43.1
ICD-10 Finland
Post-traumatic stress disorder
19.2
14.8
22
12
P29
ICPC
Psychological sympt/compl other
5.4
14.8
45
91
F60.9
ICD-10 Finland
Personality disorder, unspecified
+∞
14.7
14
*
F84.9
ICD-10 Finland
Pervasive developmental disorder, unspecified
+∞
14.7
14
*
N05AF03
ATC
chlorprothixene; systemic
+∞
14.7
14
*
F92.8
ICD-10 Finland
Other mixed disorders of conduct and emotions
+∞
14.7
14
*
F39
ICD-10 Finland
Unspecified mood [affective] disorder
82.9
14.7
16
*
IEP99
NOMESCO Finland
Other psychiatric family intervention
154.8
14.5
15
*
P03
ICPC
Feeling depressed
3.4
13.8
70
230
F31.6
ICD-10 Finland
Bipolar affective disorder, current episode mixed
+∞
13.6
13
*
IBA03
NOMESCO Finland
Psychotherapy evaluation
+∞
13.6
13
*
G24.5
ICD-10 Finland
Blepharospasm
+∞
13.6
13
*
F99
ICD-10 Finland
Mental disorder, not otherwise specified
35.2
13.6
17
5
IDY03
NOMESCO Finland
Systematic individual therapy, cognitive-behavioural
144.2
13.5
14
*
F42.0
ICD-10 Finland
Predominantly obsessional thoughts or ruminations
26.7
13.5
18
7
N05BE01
ATC
buspirone; oral
41.4
13.2
16
*
P01
ICPC
Feeling anxious/nervous/tense
2.9
13.1
88
349
P74
ICPC
Anxiety disorder/anxiety state
7.0
13.0
32
49
SPAT1307
SPAT
Psychosocial counselling and guidance
3.3
12.9
67
224
R42
ICD-10 Finland
Dizziness and giddiness
3.2
12.7
72
256
F82
ICD-10 Finland
Specific developmental disorder of motor function
72.0
12.7
14
*
F50.9
ICD-10 Finland
Eating disorder, unspecified
33.1
12.6
16
5
F88
ICD-10 Finland
Other disorders of psychological development
+∞
12.6
12
*
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
+∞
12.6
12
*
F31.7
ICD-10 Finland
Bipolar affective disorder, currently in remission
+∞
12.6
12
*
F10.09
ICD-10 Finland
Alcohol intoxication UNS
133.6
12.5
13
*
F92.9
ICD-10 Finland
Mixed disorder of conduct and emotions, unspecified
133.6
12.5
13
*
N06AA04
ATC
clomipramine; systemic
38.7
12.3
15
*
F40.1
ICD-10 Finland
Social phobias
11.5
12.2
22
20
P99
ICPC
Psychological disorders other
22.0
12.1
17
8
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
8.3
12.0
26
33
F41.09
ICD-10 Finland
UNS Panic Syndrome
13.0
11.7
20
16
P76
ICPC
Depressive disorder
5.2
11.7
36
74
F33.4
ICD-10 Finland
Recurrent depressive disorder, currently in remission
19.6
11.7
17
9
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
5.0
11.6
37
79
N05CD07
ATC
temazepam; oral
7.0
11.6
28
42
F84.8
ICD-10 Finland
Other pervasive developmental disorders
+∞
11.5
11
*
N05AG02
ATC
pimozide; oral
+∞
11.5
11
*
F93.9
ICD-10 Finland
Childhood emotional disorder, unspecified
+∞
11.5
11
*
F31.30
ICD-10 Finland
Bipolar disorder Depressive episode without somatic syndrome
+∞
11.5
11
*
Z72.8
ICD-10 Finland
Other problems related to lifestyle
123.0
11.5
12
*
N05BA06
ATC
lorazepam; systemic, sublingual
15.6
11.4
18
12
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
11.3
158
914
N05AB03
ATC
perphenazine; systemic, rectal
25.8
11.2
15
6
N03AF01
ATC
carbamazepine; oral, rectal
9.6
11.1
22
24
R56.8
ICD-10 Finland
Other and unspecified convulsions
4.3
11.0
41
103
F98.8
ICD-10 Finland
Other specified behavioural and emotional disorders with onset usually occurring in childhood and adolescence
44.5
11.0
13
*
N05BA12
ATC
alprazolam; oral
5.9
10.9
30
54
F43.22
ICD-10 Finland
Adaptation disorder with mixed anxiety and depression
10.0
10.9
21
22
F90.9
ICD-10 Finland
Hyperkinetic disorder, unspecified
28.8
10.8
14
5
SPAT1365
SPAT
Health check-up performed during first study year due to special need in students of upper secondary schools or vocational schools
28.8
10.8
14
5
N07BB01
ATC
disulfiram; oral
13.3
10.7
18
14
F33.1
ICD-10 Finland
Recurrent depressive disorder, current episode moderate
11.6
10.6
19
17
F34.1
ICD-10 Finland
Dysthymia
10.4
10.6
20
20
G51.3
ICD-10 Finland
Clonic hemifacial spasm
112.6
10.5
11
*
F61.0
ICD-10 Finland
Mixed personality disorders
112.6
10.5
11
*
F84.0
ICD-10 Finland
Childhood autism
+∞
10.5
10
*
RT420
NOMESCO Finland
NA
+∞
10.5
10
*
Z63.8
ICD-10 Finland
Other specified problems related to primary support group
+∞
10.5
10
*
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
+∞
10.5
10
*
N05AN01
ATC
lithium; oral
+∞
10.5
10
*
Z01.8
ICD-10 Finland
Other specified special examinations
2.5
10.3
87
392
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
4.5
10.0
35
83
F33.11
ICD-10 Finland
Recurrent depression, moderate episode of somatic syndrome
41.0
10.0
12
*
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.3
9.9
100
494
R4110
NOMESCO Finland
Physiotherapy
2.3
9.8
100
496
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.6
9.7
44
132
SPAT1389
SPAT
Visit based on need for special support
3.5
9.7
45
138
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
56.2
9.7
11
*
N03AX16
ATC
pregabalin; oral
2.9
9.6
59
220
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.5
9.5
82
374
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.5
9.5
82
374
F98.9
ICD-10 Finland
Unspecified behavioural and emotional disorders with onset usually occurring in childhood and adolescence
102.1
9.4
10
*
F50.0
ICD-10 Finland
Anorexia nervosa
102.1
9.4
10
*
F81.3
ICD-10 Finland
Mixed disorder of scholastic skills
+∞
9.4
9
*
ICA03
NOMESCO Finland
Psychiatric treatment plan, outsourced psychotherapy
+∞
9.4
9
*
F20.9
ICD-10 Finland
Schizophrenia, unspecified
+∞
9.4
9
*
IER04
NOMESCO Finland
Rehabilitative psychiatric group intervention, functional
+∞
9.4
9
*
IFA99
NOMESCO Finland
Other psychiatric pharmacotherapy service
+∞
9.4
9
*
N03AX12
ATC
gabapentin; oral
3.3
9.4
47
153
M79.6
ICD-10 Finland
Pain in limb
2.1
9.4
125
698
D09
ICPC
Nausea
3.3
9.3
46
148
R53
ICD-10 Finland
Malaise and fatigue
2.5
9.3
79
357
R5599
NOMESCO Finland
Other rehabilitation service
14.1
9.2
15
11
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
11.8
9.1
16
14
IEP03
NOMESCO Finland
Focused parental counselling
16.0
9.1
14
9
SPAT1241
SPAT
Extensive assessment of psychosocial situation
11.0
8.9
16
15
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
3.3
8.8
44
143
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.3
8.8
92
461
N06BA12
ATC
lisdexamfetamine; oral
51.0
8.7
10
*
R25.3
ICD-10 Finland
Fasciculation
51.0
8.7
10
*
P27
ICPC
Fear of mental disorder
16.7
8.6
13
8
J01DB01
ATC
cefalexin; oral
1.9
8.6
342
2796
F81.8
ICD-10 Finland
Other developmental disorders of scholastic skills
91.7
8.4
9
*
F60.3
ICD-10 Finland
Emotionally unstable personality disorder
91.7
8.4
9
*
P72
ICPC
Schizophrenia
91.7
8.4
9
*
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
5.7
8.4
23
42
IER01
NOMESCO Finland
Psychoeducation, group
+∞
8.4
8
*
F33.30
ICD-10 Finland
Recurrent depression, severe episode without somatic syndrome
+∞
8.4
8
*
N05AL01
ATC
sulpiride; systemic
+∞
8.4
8
*
F20.30
ICD-10 Finland
Undifferentiated schizophrenia continuous
+∞
8.4
8
*
C02AC01
ATC
clonidine; systemic
+∞
8.4
8
*
F91.9
ICD-10 Finland
Conduct disorder, unspecified
+∞
8.4
8
*
F98.02
ICD-10 Finland
Non-organic nocturnal and diurnal enuresis
+∞
8.4
8
*
F89
ICD-10 Finland
Unspecified disorder of psychological development
+∞
8.4
8
*
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
4.1
8.3
31
79
R03AC02
ATC
salbutamol; inhalant
1.8
8.3
227
1629
AA1AD
NOMESCO Finland
CT of head and brain
2.7
8.2
55
217
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.8
8.2
54
209
N06AX22
ATC
agomelatine; oral
17.6
8.1
12
7
Z08
ICPC
Social welfare problem
34.0
8.1
10
*
Z63.7
ICD-10 Finland
Other stressful life events affecting family and household
6.1
8.1
21
36
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.5
8.0
66
294
F32.1
ICD-10 Finland
Moderate depressive episode
4.5
8.0
27
63
R06.0
ICD-10 Finland
Dyspnoea
2.3
8.0
73
343
SPAT1234
SPAT
Support of social functional capacity
6.6
7.8
19
30
F41.00
ICD-10 Finland
Moderate panic disorder
45.8
7.7
9
*
Z71.8
ICD-10 Finland
Other specified counselling
2.0
7.6
116
677
P15
ICPC
Chronic alcohol abuse
25.5
7.6
10
*
SPAT1260
SPAT
Consultation of another employee
2.3
7.6
75
364
Z00.8
ICD-10 Finland
Other general examinations
3.0
7.6
43
153
L02
ICPC
Back symptom/complaint
2.8
7.5
48
185
H53.1
ICD-10 Finland
Subjective visual disturbances
4.2
7.5
27
67
L01
ICPC
Neck symptom/complaint
2.5
7.4
57
245
IBZ02
NOMESCO Finland
Somatic assessment of psychiatric patient
+∞
7.3
7
*
IEZ99
NOMESCO Finland
Other psychiatric rehabilitation intervention
+∞
7.3
7
*
F95
ICD-10 Finland
Tic disorders
+∞
7.3
7
*
RS214
NOMESCO Finland
NA
+∞
7.3
7
*
IER02
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, group
+∞
7.3
7
*
ICC01
NOMESCO Finland
Psychiatric treatment plan, transfer to psychiatric outpatient clinic
+∞
7.3
7
*
F22.0
ICD-10 Finland
Delusional disorder
+∞
7.3
7
*
F93.80
ICD-10 Finland
Generalized anxiety in the bardom age
+∞
7.3
7
*
F51.0
ICD-10 Finland
Nonorganic insomnia
2.8
7.3
46
176
L03
ICPC
Low back symptom/complaint
2.1
7.3
91
491
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.6
7.3
53
221
N06AA09
ATC
amitriptyline; systemic
4.2
7.2
26
65
D06
ICPC
Abdominal pain localized other
2.9
7.2
42
153
Z76.8
ICD-10 Finland
Persons encountering health services in other specified circumstances
5.8
7.1
19
34
R1250
NOMESCO Finland
Evaluation of functional capability
10.3
7.1
13
13
A02BC02
ATC
pantoprazole; systemic
1.8
6.9
168
1141
M03BX01
ATC
baclofen; systemic
14.1
6.9
11
8
R1210
NOMESCO Finland
Medical assessment of need and possibilities to rehabilitation
14.1
6.9
11
8
N04BC05
ATC
pramipexole; oral
5.2
6.9
20
40
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
3.5
6.8
30
90
H13
ICPC
Plugged feeling ear
2.4
6.8
59
271
Z63.5
ICD-10 Finland
Disruption of family by separation and divorce
40.7
6.8
8
*
183
Kela drug reimbursment
Lamotrigin and topiramate
40.7
6.8
8
*
IBA02
NOMESCO Finland
Evaluation of need for psychiatric rehabilitation
22.9
6.7
9
*
N06AB08
ATC
fluvoxamine; oral
22.9
6.7
9
*
D01
ICPC
Abdominal pain/cramps general
2.2
6.7
67
328
G40.9
ICD-10 Finland
Epilepsy, unspecified
6.0
6.7
17
29
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
6.0
6.7
17
29
O99.3
ICD-10 Finland
Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium
12.5
6.6
11
9
R62.0
ICD-10 Finland
Delayed milestone
8.9
6.6
13
15
J45.9
ICD-10 Finland
Asthma, unspecified
2.2
6.6
71
360
G47.3
ICD-10 Finland
Sleep apnoea
2.5
6.6
51
218
F45.8
ICD-10 Finland
Other somatoform disorders
2.9
6.5
37
133
R4170
NOMESCO Finland
Therapy forms involving educational rehabilitation
70.8
6.4
7
*
RS312
NOMESCO Finland
NA
70.8
6.4
7
*
F10.00
ICD-10 Finland
Alcohol-related acute intoxication uncomplicated
70.8
6.4
7
*
R4140
NOMESCO Finland
Psychotherapy
70.8
6.4
7
*
F50.1
ICD-10 Finland
Atypical anorexia nervosa
70.8
6.4
7
*
F40.8
ICD-10 Finland
Other phobic anxiety disorders
70.8
6.4
7
*
F80.2
ICD-10 Finland
Receptive language disorder
70.8
6.4
7
*
F41.0
ICD-10 Finland
Panic disorder [episodic paroxysmal anxiety]
5.7
6.4
17
31
F32.8
ICD-10 Finland
Other depressive episodes
11.2
6.3
11
10
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
11.2
6.3
11
10
F94.9
ICD-10 Finland
Childhood disorder of social functioning, unspecified
+∞
6.3
6
*
F31
ICD-10 Finland
Bipolar affective disorder
+∞
6.3
6
*
F31.4
ICD-10 Finland
Bipolar affective disorder, current episode severe depression without psychotic symptoms
+∞
6.3
6
*
F10.24
ICD-10 Finland
Alcohol depence active use
+∞
6.3
6
*
F90.1
ICD-10 Finland
Hyperkinetic conduct disorder
+∞
6.3
6
*
N05AF05
ATC
zuclopenthixol; systemic
+∞
6.3
6
*
F81.9
ICD-10 Finland
Developmental disorder of scholastic skills, unspecified
+∞
6.3
6
*
F31.20
ICD-10 Finland
Bipolar disorder, manic episode with mood-congruent psychotic symptoms
+∞
6.3
6
*
F31.0
ICD-10 Finland
Bipolar affective disorder, current episode hypomanic
+∞
6.3
6
*
F54
ICD-10 Finland
Psychological and behavioural factors associated with disorders or diseases classified elsewhere
+∞
6.3
6
*
IEY01
NOMESCO Finland
Psychoeducation, individual
+∞
6.3
6
*
Z01
ICPC
Poverty/financial problem
+∞
6.3
6
*
F10.25
ICD-10 Finland
Alcohol dependence continuous use
+∞
6.3
6
*
Z61.2
ICD-10 Finland
Altered pattern of family relationships in childhood
+∞
6.3
6
*
IER03
NOMESCO Finland
Psychiatric disorder-specific group intervention
+∞
6.3
6
*
188
Kela drug reimbursment
Psychosis requiring demanding treatment
+∞
6.3
6
*
N05BA02
ATC
chlordiazepoxide; systemic
27.1
6.2
8
*
N05AF01
ATC
flupentixol; systemic
27.1
6.2
8
*
N06CA01
ATC
amitriptyline and psycholeptics; systemic
3.8
6.2
24
65
P01AB01
ATC
metronidazole; oral, rectal
1.8
6.2
108
657
A02BC01
ATC
omeprazole; systemic
2.1
6.1
68
350
IEP02
NOMESCO Finland
Child-centred family therapy
10.2
6.1
11
11
SPAT1246
SPAT
Screening of depression or other psychiatric problem
2.9
6.0
35
128
A05
ICPC
Feeling ill
2.1
6.0
65
330

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
74
54
15.85
81.77
2.6
1.6
—
—
—
0
0
175
713
3.21
32.05
2.7
2.9
2.37
2.37
mmol/l
0.02
154
635
78
188
4.71
30.64
3.3
1.4
—
—
—
0
0
393
2628
3.12
27.14
4.2
3.2
14.50
14.64
pmol/l
0.52
362
2366
172
774
2.84
25.52
1.9
1.6
100.60
97.74
pmol/l
0.37
94
395
227
1197
2.61
24.36
2.6
2.4
68.37
71.76
nmol/l
1.07
219
1113
334
2122
2.65
24.13
7.1
6.0
86.03
83.81
u/l
0.29
315
2002
20
12
17.30
23.84
1.5
1.2
—
—
—
0
0
84
275
3.46
21.31
2.4
1.3
—
—
—
0
0
283
1729
2.42
21.22
3.2
2.5
—
—
—
0
0
225
1242
2.45
21.19
7.9
6.5
1.22
1.22
mmol/l
0.02
194
1070
107
411
3.03
20.79
1.6
1.3
18.23
21.17
nmol/l
1.55
96
361
136
596
2.74
20.69
2.9
1.9
169.20
442.94
u/l
1.38
128
561
225
1268
2.38
19.93
6.0
5.7
9.90
11.30
umol/l
2.12
214
1179
425
3183
2.95
19.88
5.2
3.6
1.87
1.84
mu/l
0.18
406
2960
441
3376
3.18
19.67
14.4
8.6
139.52
139.53
mmol/l
0.03
436
3249
393
2852
2.62
19.18
3.8
2.7
5.64
5.56
mmol/l
0.54
372
2623
440
3391
3.09
18.84
14.5
8.6
3.92
3.93
mmol/l
0.21
434
3252
76
253
3.35
18.69
1.7
1.7
1121.60
1113.82
nmol/l
0.03
63
194
94
363
2.95
17.94
2.3
1.3
—
—
—
0
0
152
748
2.47
17.91
3.7
3.6
8.93
8.97
mmol/l
0.02
132
669
299
1966
2.25
17.66
7.7
6.6
0.19
0.19
e9/l
0.20
263
1749
94
366
2.92
17.66
1.6
1.6
450.38
20807887.06
pmol/l
0.50
81
322
289
1891
2.21
17.06
6.9
6.5
0.04
0.04
e9/l
0.06
249
1651
289
1892
2.21
17.02
6.9
6.5
0.55
0.54
e9/l
0.63
249
1652
201
1143
2.25
16.77
6.9
6.6
1.22
1.22
mmol/l
0.23
186
1052
342
2409
2.26
16.60
4.4
3.6
8.68
7.87
mm/h
0.57
316
2234
97
397
2.78
16.55
2.3
1.3
—
—
—
0
0
186
1030
2.26
16.50
4.9
5.4
37.93
37.45
g/l
0.53
175
970
298
2001
2.17
16.13
6.9
6.3
2.01
2.02
e9/l
0.08
261
1788
97
404
2.73
15.97
2.3
1.3
—
—
—
0
0
93
379
2.78
15.96
6.0
6.0
0.85
0.82
mmol/l
0.57
86
360
97
406
2.71
15.80
2.3
1.3
—
—
—
0
0
95
404
2.66
14.95
2.0
1.3
—
—
—
0
0
274
1823
2.08
14.70
7.1
6.8
8.58
8.27
%
0.98
262
1732
147
779
2.24
14.18
2.8
2.2
52.12
56.92
u/l
0.52
137
725
285
1940
2.06
14.18
6.9
6.4
31.73
31.85
%
0.06
271
1844
270
1810
2.04
13.93
7.1
6.6
2.93
2.93
%
0.02
254
1708
330
2381
2.08
13.86
4.1
2.6
30.67
32.18
u/l
0.30
313
2275
263
1753
2.03
13.72
7.2
6.7
0.65
0.66
%
0.22
250
1657
305
2150
2.03
13.51
10.6
7.8
3.73
3.81
e9/l
0.27
268
1859
129
666
2.25
13.14
2.9
2.9
1.02
1.02
kg/l
0.37
11
115
277
1905
1.99
12.96
6.9
6.3
53.19
53.80
%
0.37
266
1812
209
1308
2.01
12.78
6.4
6.7
—
—
—
0
0
28
61
4.80
12.26
2.0
1.1
—
—
—
0
0
249
1734
1.85
10.44
4.5
4.0
6.21
6.33
mmol/l
0.44
227
1551
105
547
2.16
10.24
3.5
2.7
—
—
—
0
0
118
643
2.08
10.24
3.8
4.0
7.38
7.40
ph
2.19
22
128
111
597
2.10
9.95
5.1
3.5
—
—
—
0
0
46
166
2.95
9.77
6.3
3.0
—
—
—
0
0
454
3901
2.42
9.68
10.6
7.2
27.54
26.99
u/l
0.23
445
3773
58
240
2.60
9.52
2.1
2.0
185.15
36.20
u/l
0.45
48
201
150
916
1.90
9.31
8.6
6.8
—
—
—
0
0
69
314
2.38
9.25
3.0
2.6
2.42
2.42
mmol/l
0.23
62
269
134
792
1.94
9.16
3.7
2.6
31.42
44.25
ng/l
0.31
69
370
243
1732
1.77
9.01
3.2
2.6
76.47
75.57
ug/l
0.04
229
1640
247
1773
1.76
8.90
10.1
8.4
0.00
0.00
e9/l
0.54
196
1429
128
755
1.93
8.76
3.0
2.7
2.73
2.69
mg/l
0.08
113
660
24
62
4.01
8.51
1.1
1.1
—
—
—
0
0
104
594
1.94
7.75
2.5
2.5
563.19
589.91
mosm/kgh2o
0.41
85
517
21
54
4.01
7.50
1.1
1.1
—
—
—
0
0
61
291
2.24
7.31
1.8
2.7
10.57
10.18
g/l
0.44
55
269
306
2408
1.67
7.29
4.4
3.4
—
—
—
0
0
376
3130
1.75
7.22
3.6
3.0
4.47
4.59
mmol/l
1.46
360
2973
148
967
1.75
7.09
3.4
2.9
30.58
71.22
e6/l
0.62
115
719
12
20
6.12
6.93
1.0
1.3
—
—
—
0
0
372
3107
1.72
6.84
3.4
2.9
1.37
1.43
mmol/l
1.78
352
2945
375
3140
1.72
6.82
3.8
3.1
2.74
2.78
mmol/l
0.48
357
2957
176
1218
1.68
6.79
1.5
1.5
0.61
1.70
u/ml
2.71
41
279
319
2565
1.64
6.74
4.4
3.6
36.98
37.63
mmol/mol
0.56
305
2441
69
358
2.07
6.69
2.1
1.5
—
—
—
0
0
74
398
2.00
6.51
7.3
7.3
1.13
1.20
mmol/l
1.13
68
376
133
865
1.73
6.40
3.4
2.8
0.33
0.28
e6/l
0.18
100
635
6
0
+∞
6.26
4.2
0.0
112.67
—
nmol/l
—
6
0
134
883
1.70
6.12
3.3
2.7
—
—
—
0
0
10
16
6.35
5.97
3.0
6.8
15.89
23.54
ug/l
—
10
16
76
429
1.91
5.80
1.3
1.2
—
—
—
0
0
168
1194
1.61
5.64
4.0
3.3
19.08
44.11
e6/l
2.25
122
776
156
1091
1.62
5.59
1.6
1.5
1.88
1.93
g/l
0.17
89
646
439
3917
1.84
5.56
14.3
8.6
19.13
22.43
mg/l
1.66
329
2798
62
331
1.99
5.56
4.0
4.4
8.62
7.07
umol/l
0.15
53
279
105
663
1.73
5.55
1.7
1.6
1.52
1.28
mmol/l
1.27
90
590
21
67
3.23
5.52
1.2
2.8
—
—
—
0
0
36
157
2.39
5.32
2.5
3.6
—
—
—
0
0
41
190
2.26
5.29
2.9
3.4
80.73
61.85
e9/l
1.01
29
115
101
641
1.72
5.23
2.4
2.5
10.93
6.97
e6/l
1.02
83
566
351
2983
1.56
5.10
3.3
2.7
1.21
1.17
mmol/l
0.58
332
2829
18
55
3.36
5.07
2.0
3.9
—
—
—
0
0
81
487
1.79
5.05
3.5
2.5
1.84
2.13
e6/l
0.23
51
258
220
1698
1.52
4.99
4.7
4.0
0.00
0.00
estimate
0.00
47
354
221
1716
1.51
4.83
3.6
2.9
0.00
0.00
estimate
0.00
45
336
26
102
2.63
4.79
2.2
2.4
—
—
—
0
0
131
908
1.59
4.78
4.6
5.4
1.09
1.13
inr
0.49
48
309
99
650
1.65
4.48
3.1
2.4
1.21
0.95
mg/l
0.45
64
453
106
714
1.61
4.32
3.1
2.9
—
—
—
0
0
401
3563
1.57
4.32
17.5
10.6
13.23
13.19
%
0.25
394
3501
31
624
0.46
4.30
1.3
1.2
—
—
—
0
0
20
73
2.81
4.23
1.3
3.1
—
—
—
0
0
215
1695
1.46
4.20
3.4
2.9
0.00
0.00
estimate
0.00
45
337
34
161
2.19
4.20
1.5
1.2
—
—
—
0
0
53
296
1.88
4.19
5.9
5.5
5.21
5.06
kpa
0.91
47
275
57
327
1.84
4.14
6.9
8.0
—
—
—
0
0
61
358
1.80
4.12
4.4
6.0
2.00
1.46
mmol/l
0.92
50
285
491
4639
2.36
3.99
21.0
11.9
88.35
88.24
fl
0.21
485
4583
491
4639
2.36
3.99
21.0
11.9
29.59
29.65
pg
0.27
485
4582
491
4640
2.36
3.97
21.1
11.9
4.66
4.65
e12/l
0.09
474
4488
448
4114
1.70
3.94
12.5
7.4
—
—
—
0
0
491
4643
2.34
3.91
21.1
12.0
6.70
6.60
e9/l
0.56
474
4491
490
4630
2.30
3.91
21.2
12.0
260.59
256.81
e9/l
0.68
476
4483
491
4648
2.31
3.82
21.2
12.0
137.42
137.49
g/l
0.04
485
4591
14
44
3.24
3.80
1.6
2.4
1.10
1.30
e9/l
—
5
26
35
175
2.07
3.79
1.6
1.4
—
—
—
0
0
123
883
1.52
3.76
4.7
4.2
—
—
—
0
0
54
315
1.80
3.73
1.2
1.3
—
—
—
0
0
12
35
3.49
3.64
1.2
1.2
—
—
—
0
0
37
193
1.99
3.58
7.3
18.7
1.13
1.23
inr
—
8
38
52
304
1.79
3.57
1.2
1.2
135.94
131.89
iu/ml
0.03
16
107
32
159
2.08
3.53
3.7
5.3
1.22
1.23
mmol/l
0.11
26
144
50
296
1.76
3.30
1.3
1.3
230.25
342.59
u/ml
0.53
45
270
74
487
1.61
3.30
1.3
1.2
18.74
20.58
iu/ml
0.08
17
153
181
1433
1.41
3.27
2.7
2.1
—
—
—
0
0
15
55
2.78
3.18
1.8
1.3
309.33
358.89
ug/g
—
6
33
106
763
1.49
3.17
2.9
2.3
—
—
—
0
0
13
44
3.01
3.15
1.2
3.3
—
—
—
0
0
55
340
1.69
3.13
3.9
2.5
2572.99
4748.57
u/l
0.45
19
145
119
886
1.45
2.99
3.3
3.1
0.00
0.00
estimate
0.50
45
341
67
442
1.59
2.97
3.1
2.7
76.31
1083.66
ng/l
2.46
29
266
8
17
4.76
2.93
1.0
1.5
—
—
—
0
0
146
1133
1.40
2.91
1.8
1.8
—
—
—
0
0
74
503
1.55
2.89
3.4
3.4
892.74
77.63
mg/l
0.48
51
360
7
13
5.44
2.87
1.7
1.1
—
—
—
0
0
6
9
6.73
2.87
1.2
1.6
—
—
—
0
0
76
523
1.53
2.81
4.1
4.1
12.19
9.26
mg/mmol
0.19
51
376
436
4055
1.50
2.75
14.8
9.0
40.42
40.70
%
0.33
346
3490
11
37
3.02
2.70
1.6
8.2
—
—
—
0
0
16
67
2.43
2.65
1.6
1.5
—
—
—
0
0
7
15
4.72
2.60
8.4
5.9
—
—
—
0
0
42
255
1.70
2.58
6.9
7.3
105.45
104.49
mmol/l
0.69
42
249
69
475
1.52
2.55
1.5
1.5
301.82
437.96
titre
1.09
11
98
38
225
1.74
2.55
1.1
1.2
—
—
—
0
0
53
344
1.60
2.53
2.7
1.8
—
—
—
0
0
91
669
1.44
2.43
2.0
1.6
—
—
—
0
0
40
246
1.68
2.36
1.5
1.3
175.29
264.65
miu/ml
0.84
14
136
14
59
2.41
2.31
3.1
6.2
3.90
2.59
mmol/l
—
7
28
92
691
1.40
2.19
3.2
3.3
144.52
131.25
ug/g
0.14
71
553
65
459
1.48
2.15
1.3
1.2
11.17
6.72
u/ml
0.24
25
177
25
138
1.85
2.13
3.2
4.9
6.51
5.53
ug/l
0.09
20
109
8
25
3.23
2.10
1.1
1.2
266.88
286.89
mg/l
—
8
19
5
10
5.04
2.07
1.0
1.0
—
—
—
0
0
39
249
1.61
2.02
7.5
5.8
—
—
—
0
0
7
21
3.36
1.97
1.1
1.3
—
—
—
0
0
8
27
2.99
1.94
1.8
3.3
—
—
—
0
0
21
115
1.86
1.85
1.3
1.3
—
—
—
0
0
38
248
1.57
1.82
7.8
4.2
0.93
0.78
%
0.18
15
65
9
35
2.60
1.81
2.1
2.7
8.00
16.40
%
—
9
35
16
81
2.01
1.76
2.9
2.8
—
—
—
0
0
34
218
1.60
1.75
1.7
1.7
9.92
14.25
iu/l
0.78
25
167
35
227
1.58
1.73
7.2
3.9
0.64
0.28
%
0.71
11
46
7
24
2.94
1.72
1.3
1.3
—
—
—
0
0
7
24
2.94
1.72
1.7
2.4
32.57
32.67
pg
—
7
24
45
310
1.50
1.71
1.6
1.5
—
—
—
0
0
27
165
1.67
1.68
1.3
1.5
331.38
199.78
u/ml
0.84
13
91
7
25
2.82
1.65
1.7
3.2
—
—
—
0
0
36
238
1.55
1.65
8.1
4.2
0.23
0.10
%
0.47
13
60
20
113
1.80
1.62
1.0
1.1
—
—
—
0
0
5
14
3.60
1.62
3.4
3.1
2.04
2.94
nmol/l
—
5
14
8
32
2.52
1.60
1.1
2.3
33.25
22.91
%
—
8
32
31
200
1.59
1.58
1.4
1.5
—
—
—
0
0
31
202
1.57
1.52
1.1
1.2
—
—
—
0
0
6
21
2.88
1.51
1.3
1.2
338.00
189.28
iu/ml
—
6
21
21
124
1.72
1.49
1.0
1.1
3.01
8.97
u/ml
1.66
12
66
28
179
1.60
1.49
3.7
2.0
—
—
—
0
0
9
37
2.46
1.48
1.7
1.7
—
—
—
0
0
18
103
1.77
1.42
11.4
7.7
—
—
—
0
0
75
942
0.76
1.39
1.6
1.6
—
—
—
0
0
41
292
1.44
1.35
2.4
1.9
14.55
13.88
nmol/l
0.11
33
265
21
128
1.67
1.35
1.5
1.7
—
—
—
0
0
20
122
1.67
1.29
1.1
1.1
—
—
—
0
0
12
62
1.96
1.28
2.4
6.9
—
—
—
0
0
8
35
2.31
1.27
1.1
1.1
—
—
—
0
0
21
131
1.63
1.25
1.3
1.6
35.00
38.03
nmol/l
0.28
21
131
21
131
1.63
1.25
1.9
1.6
—
—
—
0
0
6
25
2.42
1.24
4.3
1.5
—
—
—
0
0
19
116
1.66
1.23
1.1
1.1
1.66
8.42
u/ml
2.79
12
66
30
205
1.49
1.23
1.6
1.8
5.41
7.28
u/l
0.96
24
153
10
49
2.06
1.22
1.0
4.0
—
—
—
0
0
15
86
1.77
1.20
1.6
1.6
—
—
—
0
0
33
232
1.45
1.18
8.7
4.2
0.00
0.07
%
—
10
54
29
204
1.45
1.05
8.4
6.6
0.88
0.76
mmol/l
0.09
23
165
32
230
1.42
1.04
1.1
1.2
3.81
1.56
u/ml
0.53
20
133
127
1103
1.20
1.00
2.0
1.7
—
—
—
0
0
53
417
1.30
0.99
1.6
1.5
—
—
—
0
0
27
190
1.44
0.99
1.2
1.2
0.77
4.25
u/ml
1.69
11
62
23
157
1.49
0.98
9.7
7.7
121.52
124.40
g/l
0.29
23
150
11
62
1.79
0.95
2.2
1.7
—
—
—
0
0
7
37
1.90
0.94
2.0
1.5
286.71
295.52
mosm/kgh2o
—
7
29
45
350
1.31
0.92
1.4
1.4
—
—
—
0
0
6
28
2.16
0.91
1.8
1.0
—
—
—
0
0
50
396
1.29
0.91
1.6
1.3
—
—
—
0
0
29
211
1.40
0.90
1.1
1.2
3.10
6.86
u/ml
1.57
21
158
6
29
2.08
0.89
1.0
1.4
—
—
nmol/l
—
0
0
21
144
1.48
0.88
3.7
3.3
64.93
144.86
ng/l
1.59
14
126
16
103
1.57
0.88
1.1
1.2
—
—
—
0
0
10
56
1.80
0.88
1.2
6.1
—
—
—
0
0
6
30
2.01
0.87
1.5
1.3
—
—
—
0
0
6
30
2.01
0.87
1.8
1.2
—
—
—
0
0
6
32
1.88
0.82
1.8
1.2
—
—
—
0
0
16
106
1.53
0.79
5.5
2.5
—
—
—
0
0
43
341
1.28
0.79
2.1
1.5
—
—
—
0
0
0
27
0.00
0.77
0.0
2.8
—
17.33
—
0
27
6
34
1.77
0.76
1.5
1.1
—
—
—
0
0
10
59
1.71
0.76
1.2
1.3
—
—
—
0
0
18
124
1.47
0.76
10.9
8.6
95.07
95.88
%
0.64
18
124
117
1036
1.17
0.75
3.2
2.5
—
—
—
0
0
5
24
2.09
0.74
2.4
3.6
741.40
804.67
u/ml
—
5
24
16
108
1.50
0.74
1.5
1.7
—
85.83
—
0
12
11
68
1.63
0.72
1.5
1.4
—
1.90
—
0
7
18
126
1.44
0.71
10.8
8.5
1.09
1.13
%
0.07
18
126
14
93
1.52
0.70
2.7
1.8
3.05
7.29
iu/l
—
6
36
16
110
1.47
0.69
1.1
1.2
—
—
—
0
0
16
110
1.47
0.69
1.2
1.2
—
—
—
0
0
27
206
1.33
0.67
1.1
1.2
0.76
1.25
u/ml
0.34
18
136
45
368
1.24
0.66
1.8
2.0
—
—
—
0
0
5
28
1.79
0.66
1.0
1.1
2967.60
1623.39
miu/ml
—
5
28
11
70
1.58
0.65
1.4
1.6
—
—
—
0
0
10
62
1.63
0.65
2.4
2.7
—
—
—
0
0
5
29
1.73
0.64
1.4
4.7
2.94
2.67
mmol/l
—
5
29
5
29
1.73
0.64
3.8
1.9
91.52
91.31
%
—
5
29
110
983
1.15
0.63
2.6
2.1
—
—
—
0
0
5
30
1.67
0.61
1.0
1.2
—
—
—
0
0
5
30
1.67
0.61
5.8
3.3
1.92
1.69
umol/l
—
5
30
118
1304
0.88
0.60
2.1
2.0
—
—
—
0
0
122
1344
0.88
0.59
1.6
1.7
—
—
—
0
0
0
23
0.00
0.58
0.0
3.1
—
2.18
—
0
23
6
35
1.72
0.58
1.0
1.4
—
—
—
0
0
6
37
1.63
0.55
4.0
1.8
2.20
1.55
mmol/l
—
6
37
6
38
1.59
0.54
2.3
5.0
—
—
—
0
0
17
126
1.36
0.52
11.3
8.5
0.50
0.70
%
1.92
17
126
12
83
1.46
0.52
1.8
1.7
—
—
—
0
0
28
346
0.80
0.51
1.2
1.3
—
—
—
0
0
15
109
1.39
0.51
1.0
1.1
0.09
0.67
u/ml
—
6
43
6
41
1.47
0.50
10.3
3.6
—
—
—
0
0
17
222
0.76
0.48
2.0
1.4
—
—
—
0
0
25
202
1.25
0.44
1.9
1.7
3.38
3.92
e9/l
0.63
20
180
5
31
1.62
0.43
2.2
1.6
—
—
—
0
0
56
492
1.16
0.43
3.5
3.4
1.68
2.34
ug/l
0.41
50
451
8
56
1.44
0.42
1.0
1.1
—
—
—
0
0
8
57
1.41
0.42
1.3
1.2
—
—
—
0
0
5
33
1.52
0.41
1.2
1.3
29.91
42.59
nmol/l
—
5
28
12
89
1.36
0.38
13.5
7.3
—
—
—
0
0
16
125
1.29
0.37
1.9
1.5
—
—
—
0
0
13
99
1.32
0.36
1.1
1.2
—
—
—
0
0
6
44
1.37
0.34
2.3
2.5
—
—
—
0
0
7
53
1.33
0.31
1.0
1.2
26.96
13.06
u/l
—
7
48
7
54
1.30
0.30
2.1
3.9
1.53
1.38
mmol/l
—
7
54
12
93
1.30
0.30
4.0
4.1
—
—
—
0
0
37
328
1.14
0.27
3.4
3.1
—
—
—
0
0
161
1547
1.06
0.22
4.1
3.7
—
—
—
0
0
5
41
1.22
0.22
1.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
3.5
—
—
—
0
0
0
11
0.00
0.21
0.0
2.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.8
—
—
—
0
0
22
192
1.15
0.21
1.5
1.4
—
—
—
0
0
5
43
1.16
0.21
1.0
1.0
—
—
—
0
0
6
52
1.16
0.19
1.0
1.1
—
—
—
0
0
16
137
1.17
0.19
5.4
6.3
0.45
0.26
g/l
—
9
79
7
59
1.19
0.18
1.0
1.5
—
—
—
0
0
102
976
1.06
0.17
2.1
1.8
—
—
—
0
0
8
69
1.16
0.16
2.1
1.8
1.39
6.28
ug/l
—
8
56
22
197
1.12
0.15
1.6
1.5
—
—
—
0
0
23
209
1.11
0.13
1.1
1.1
—
—
—
0
0
27
291
0.92
0.11
3.1
2.3
0.64
0.76
ug/l
0.32
15
139
21
193
1.09
0.10
1.5
1.5
—
—
—
0
0
16
145
1.11
0.09
1.2
1.1
—
—
—
0
0
5
48
1.04
0.09
1.6
1.7
—
—
—
0
0
6
71
0.84
0.07
2.7
2.3
25.98
15.32
mu/l
—
6
66
34
327
1.04
0.05
1.1
1.2
—
—
—
0
0
12
112
1.07
0.03
1.2
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
4.0
—
1.10
—
0
6
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
270.67
—
0
6
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
6
66
0.91
0.00
1.2
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint KRA_PSY_TIC_EXMORE and mortality.

Females

Parameter HR [95% CI] p-value
KRA_PSY_TIC_EXMORE 1.34 [0.94, 1.92] 0.111
Birth year 0.994 [0.99, 1.0] 0.182

During the follow-up period (1.1.1998 — 31.12.2019), 63 out of 2389 females with KRA_PSY_TIC_EXMORE died.

Males

Parameter HR [95% CI] p-value
KRA_PSY_TIC_EXMORE 1.569 [1.19, 2.07] 0.001
Birth year 0.99 [0.98, 1.0] 0.03

During the follow-up period (1.1.1998 — 31.12.2019), 92 out of 6900 males with KRA_PSY_TIC_EXMORE died.

Mortality risk

Mortality risk for people of age

years, who have KRA_PSY_TIC_EXMORE.

N-year risk Females Males
1 0.136% 0.294%
5 0.77% 1.889%
10 1.82% 4.912%
15 3.571% 9.327%
20 6.152% 15.684%

Relationships between endpoints

Index endpoint: KRA_PSY_TIC_EXMORE – Tic and related disorders

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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