No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
513 |
4. Check minimum number of eventsNone |
513 |
5. Include endpointsNone |
513 |
6. Filter based on genotype QC (FinnGen only) |
513 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF12
- Parent code in ICD-10
- F90-F98
- Name in latin
- Perturbationes ticiformes
Similar endpoints
↥List of similar endpoints to
Tic and related disorders
based on the number of shared cases.
Similar with more cases:
- Tic and related disorders
- Any mental disorder
- Psychiatric diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 12184 | 3427 | 8742 |
| Only index persons | 9944 | 2898 | 7046 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.20 | 0.10 | 0.24 |
| Only index persons | 0.22 | 0.11 | 0.27 |
| Median age at first event (years) | |||
| Whole population | 9.93 | 10.84 | 9.52 |
| Only index persons | 10.81 | 12.11 | 10.28 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 513 | 261 | 252 |
| Unadjusted period prevalence (%) | 0.10 | 0.09 | 0.11 |
| Median age at first event (years) | 14.66 | 17.04 | 12.20 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 448
- Matched controls
- 4481
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
F95.9
ICD-10 Finland
Tic disorder, unspecified
+∞
172.3
154
*
F95.2
ICD-10 Finland
Combined vocal and multiple motor tic disorder [de la Tourette]
1083.7
159.9
147
*
F95.0
ICD-10 Finland
Transient tic disorder
1247.9
104.7
98
*
F95.1
ICD-10 Finland
Chronic motor or vocal tic disorder
895.6
78.9
75
*
N05AX08
ATC
risperidone; systemic
8.9
51.4
119
175
N05AD01
ATC
haloperidol; systemic
23.8
35.7
51
24
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
4.3
33.2
149
469
N05AX12
ATC
aripiprazole; systemic
7.2
31.9
82
135
N03AE01
ATC
clonazepam; systemic
9.5
27.5
58
69
30620
ICD-8 Finland
Special symptoms not elsewhere classified, Tics
+∞
27.4
26
*
F95.8
ICD-10 Finland
Other tic disorders
+∞
25.2
24
*
N05BA04
ATC
oxazepam; oral
3.6
24.2
130
461
N06AB06
ATC
sertraline; oral
4.1
22.3
95
274
N05AH04
ATC
quetiapine; oral
3.3
22.1
134
515
F90.0
ICD-10 Finland
Disturbance of activity and attention
4.7
21.8
79
194
N06BA04
ATC
methylphenidate; oral
4.8
18.4
64
150
3072A
ICD-9 Finland
Special symptoms or syndromes not elsewhere classified, Tics[NYKIMISHÄIRIÖ, MÄÄRITTELEMÄTÖN]
+∞
16.8
16
*
N06AB03
ATC
fluoxetine; oral
3.6
16.3
80
257
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
4.1
15.9
64
173
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
3.0
15.5
101
396
N06AX16
ATC
venlafaxine; oral
3.2
14.2
83
301
F42.2
ICD-10 Finland
Mixed obsessional thoughts and acts
8.8
13.7
29
35
N06BA09
ATC
atomoxetine; oral
26.7
13.5
18
7
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
3.6
13.3
62
190
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
4.2
13.3
52
137
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.4
13.0
65
211
IBZ01
NOMESCO Finland
Profession-specific psychiatric evaluation
4.8
12.9
43
96
N05BA01
ATC
diazepam; systemic, rectal
3.3
12.8
67
225
331
Kela drug reimbursment
Atomoxetine, dexamphetamine, guanfacine and lisdexamphetamine
9.7
12.6
25
27
F42.9
ICD-10 Finland
Obsessive-compulsive disorder, unspecified
10.5
12.6
24
24
G24.5
ICD-10 Finland
Blepharospasm
133.6
12.5
13
*
N05AH03
ATC
olanzapine; systemic
3.5
12.4
59
184
F84.5
ICD-10 Finland
Asperger syndrome
8.6
12.2
26
32
IGY99
NOMESCO Finland
Other psychiatric treatment contact
4.1
11.7
46
122
IBZ06
NOMESCO Finland
Evaluation concerning developmental neuropsychiatry
10.5
11.6
22
22
N05AG02
ATC
pimozide; oral
+∞
11.5
11
*
G51.3
ICD-10 Finland
Clonic hemifacial spasm
+∞
11.5
11
*
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
3.6
11.5
52
156
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
4.7
11.2
38
87
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.5
11.1
52
160
N03AX09
ATC
lamotrigine; oral
3.9
11.0
45
124
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.5
10.8
93
426
IBA04
NOMESCO Finland
Extensive initial psychiatric evaluation
4.3
10.5
39
98
N06AB04
ATC
citalopram; systemic
2.6
10.2
78
332
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.7
10.0
72
298
IGP01
NOMESCO Finland
Psychiatric family contact
4.5
9.8
34
80
N03AG01
ATC
valproic acid; systemic, rectal
3.4
9.6
47
150
F29
ICD-10 Finland
Unspecified nonorganic psychosis
3.5
9.4
44
136
N06AB10
ATC
escitalopram; oral
2.1
9.1
111
596
F42.1
ICD-10 Finland
Predominantly compulsive acts [obsessional rituals]
9.3
9.1
18
20
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
3.4
9.1
43
134
C07AA05
ATC
propranolol; systemic
2.3
8.8
89
437
R42
ICD-10 Finland
Dizziness and giddiness
2.5
8.6
72
323
N06AX12
ATC
bupropion; oral
2.9
8.5
52
192
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
2.4
8.4
74
341
N06AX11
ATC
mirtazapine; oral
2.0
8.3
119
681
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
6.1
8.1
21
36
IGV01
NOMESCO Finland
Psychiatric network contact
4.3
7.8
28
69
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
3.8
7.7
32
90
N05CF01
ATC
zopiclone; oral
2.2
7.7
84
426
F33.00
ICD-10 Finland
Recurrent depression, mild episode without somatic syndrome
6.9
7.7
18
27
F92.8
ICD-10 Finland
Other mixed disorders of conduct and emotions
10.3
7.6
14
14
IBA01
NOMESCO Finland
Diagnostic and symptom-mapping evaluation
3.7
7.6
32
92
SPAT1240
SPAT
Therapeutic discussion
2.2
7.4
83
428
F42.0
ICD-10 Finland
Predominantly obsessional thoughts or ruminations
6.4
7.3
18
29
F95
ICD-10 Finland
Tic disorders
+∞
7.3
7
*
N06AA04
ATC
clomipramine; systemic
8.1
7.2
15
19
ICB03
NOMESCO Finland
Psychiatric treatment plan, monitoring
4.3
7.1
25
61
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.1
7.1
37
126
N04AA02
ATC
biperiden; systemic
6.5
7.0
17
27
IGY02
NOMESCO Finland
Psychiatric monitoring contact
3.1
7.0
36
121
N06AB05
ATC
paroxetine; oral
3.7
6.9
29
83
M79.6
ICD-10 Finland
Pain in limb
1.9
6.9
125
774
F93.89
ICD-10 Finland
Other childhood emotional disorders
4.0
6.9
26
68
Z03.2
ICD-10 Finland
Observation for suspected mental and behavioural disorders
4.2
6.8
24
59
F80.1
ICD-10 Finland
Expressive language disorder
4.8
6.8
21
45
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.0
6.8
100
574
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.1
6.8
82
435
C02AC01
ATC
clonidine; systemic
40.7
6.8
8
*
R25.3
ICD-10 Finland
Fasciculation
17.0
6.8
10
6
ICA03
NOMESCO Finland
Psychiatric treatment plan, outsourced psychotherapy
22.9
6.7
9
*
SPAT1243
SPAT
Psychiatric/psychological examination
2.9
6.6
38
137
T36
ICD-10 Finland
Poisoning by systemic antibiotics
3.0
6.5
37
131
IFA01
NOMESCO Finland
Psychiatric pharmacotherapy plan, not specified
3.7
6.5
27
77
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.0
6.5
82
445
F84.0
ICD-10 Finland
Childhood autism
14.6
6.4
10
7
F41.8
ICD-10 Finland
Other specified anxiety disorders
3.4
6.4
29
89
F83
ICD-10 Finland
Mixed specific developmental disorders
3.7
6.4
26
73
F32.00
ICD-10 Finland
Mild depressive episode without somatic syndrome
3.0
6.3
34
119
N03AF01
ATC
carbamazepine; oral, rectal
4.2
6.3
22
54
F84.9
ICD-10 Finland
Pervasive developmental disorder, unspecified
7.2
6.3
14
20
R03AC02
ATC
salbutamol; inhalant
1.6
6.2
227
1719
Z72.8
ICD-10 Finland
Other problems related to lifestyle
8.8
6.1
12
14
SPAT1365
SPAT
Health check-up performed during first study year due to special need in students of upper secondary schools or vocational schools
6.8
6.1
14
21
ICB02
NOMESCO Finland
Psychiatric treatment plan, extended/prolonged
5.3
6.1
17
33
F31.8
ICD-10 Finland
Other bipolar affective disorders
5.7
6.0
16
29
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
393
2986
2.35
15.12
4.2
3.6
14.50
14.53
pmol/l
0.10
362
2714
175
982
2.19
14.73
2.7
3.0
2.37
2.37
mmol/l
0.20
154
883
227
1465
1.99
12.69
2.6
2.7
68.37
70.18
nmol/l
0.44
219
1352
129
675
2.22
12.67
2.5
1.6
1.54
1.40
%
1.52
115
620
172
1040
1.98
11.33
1.9
1.6
100.60
98.22
pmol/l
0.31
94
530
193
1223
1.93
11.01
3.4
3.3
27.64
32.79
u/l
2.50
183
1160
425
3500
2.25
11.01
5.2
4.2
1.87
1.84
mu/l
0.21
406
3264
334
2535
1.91
10.78
7.1
6.3
86.03
86.10
u/l
0.01
315
2382
393
3161
2.04
10.55
3.8
3.0
5.64
5.60
mmol/l
0.20
372
2903
94
471
2.22
10.10
1.6
1.6
450.38
16302149.74
pmol/l
0.50
81
411
441
3730
2.30
10.00
14.4
11.1
139.52
139.54
mmol/l
0.05
436
3597
342
2652
1.87
9.90
4.4
3.7
8.68
8.24
mm/h
0.26
316
2450
136
792
1.98
9.77
2.9
2.3
169.20
383.24
u/l
1.44
128
746
225
1548
1.81
9.57
6.0
6.1
9.90
10.97
umol/l
1.59
214
1453
440
3740
2.24
9.49
14.5
11.1
3.92
3.91
mmol/l
0.10
434
3591
107
582
2.06
9.26
1.6
1.3
18.23
19.87
nmol/l
0.71
96
503
225
1565
1.78
9.10
7.9
7.8
1.22
1.22
mmol/l
0.11
194
1346
186
1228
1.81
8.94
4.9
5.9
37.93
37.59
g/l
0.34
175
1149
285
2137
1.75
8.75
6.9
7.3
31.73
31.73
%
0.00
271
2033
93
496
2.07
8.44
6.0
7.4
0.85
0.81
mmol/l
1.00
86
467
277
2099
1.69
7.86
6.9
7.2
53.19
53.81
%
0.38
266
1997
152
981
1.78
7.68
3.7
3.6
8.93
8.87
mmol/l
0.04
132
875
147
946
1.78
7.48
2.8
2.6
52.12
56.92
u/l
0.53
137
866
76
394
2.09
7.40
1.7
1.6
1121.60
1149.74
nmol/l
0.11
63
304
305
2403
1.66
7.19
10.6
9.7
3.73
3.88
e9/l
0.67
268
2071
330
2668
1.66
6.90
4.1
3.1
30.67
33.91
u/l
0.83
313
2551
201
1451
1.63
6.52
6.9
7.9
1.22
1.22
mmol/l
0.17
186
1340
16
39
4.20
6.13
1.0
1.1
—
—
—
0
0
129
848
1.70
5.92
2.9
3.3
1.02
1.02
kg/l
0.45
11
110
167
1186
1.61
5.62
3.4
3.6
—
—
—
0
0
134
905
1.65
5.51
3.7
2.8
31.42
40.27
ng/l
0.21
69
428
10
18
5.65
5.34
3.0
3.3
15.89
19.59
ug/l
—
10
18
11
23
4.87
5.03
1.3
2.6
11.03
16.54
umol/l
1.05
11
23
243
1917
1.51
4.96
3.2
3.0
76.47
73.19
ug/l
0.15
229
1794
454
4129
1.87
4.91
10.6
8.3
27.54
27.70
u/l
0.06
445
3990
249
2000
1.48
4.51
4.5
5.1
6.21
6.37
mmol/l
0.63
227
1812
128
899
1.56
4.38
3.0
2.5
2.73
2.72
mg/l
0.02
113
774
40
203
2.05
4.15
1.8
1.6
—
—
—
0
0
376
3318
1.50
3.95
3.6
3.2
4.47
4.55
mmol/l
0.84
360
3128
364
3198
1.48
3.85
12.7
8.7
100.70
100.40
ml/min/173m2
0.08
295
2416
372
3298
1.47
3.63
3.4
3.1
1.37
1.41
mmol/l
0.76
352
3099
176
1370
1.43
3.55
1.5
1.5
0.61
1.78
u/ml
2.10
41
310
8
13
6.23
3.51
1.0
1.1
—
—
—
0
0
8
13
6.23
3.51
1.0
1.1
—
—
—
0
0
375
3338
1.46
3.51
3.8
3.3
2.74
2.77
mmol/l
0.28
357
3116
64
405
1.66
3.33
1.1
1.0
—
—
—
0
0
14
48
2.97
3.32
1.0
1.1
—
—
—
0
0
220
1797
1.39
3.32
4.7
4.5
0.00
0.00
estimate
0.00
47
378
319
2773
1.40
3.30
4.4
4.0
36.98
37.47
mmol/mol
0.39
305
2627
133
994
1.46
3.30
3.4
3.4
0.33
0.24
e6/l
0.41
100
737
22
97
2.32
3.24
1.6
1.5
—
—
—
0
0
69
450
1.62
3.20
3.0
2.8
2.42
2.42
mmol/l
0.23
62
384
47
276
1.77
3.20
6.1
6.0
—
—
—
0
0
439
4060
1.56
3.17
14.3
10.5
19.13
22.03
mg/l
1.39
329
2929
221
1817
1.38
3.17
3.6
3.3
0.00
0.00
estimate
0.00
45
360
58
363
1.67
3.15
2.1
2.5
185.15
31.19
u/l
0.47
48
302
36
196
1.90
3.11
1.6
1.7
—
—
—
0
0
7
12
5.90
3.03
1.0
1.0
—
—
—
0
0
7
12
5.90
3.03
1.0
1.0
—
—
—
0
0
7
12
5.90
3.03
1.0
1.2
—
—
—
0
0
17
69
2.51
2.99
1.3
1.2
—
—
—
0
0
16
63
2.59
2.98
1.2
1.6
—
—
—
0
0
47
287
1.70
2.81
2.1
1.8
—
—
—
0
0
28
146
1.97
2.76
1.6
1.6
—
—
—
0
0
81
568
1.51
2.74
3.5
3.2
1.84
3.09
e6/l
1.33
51
306
13
48
2.75
2.73
1.1
1.1
—
—
—
0
0
351
3147
1.37
2.71
3.3
2.9
1.21
1.21
mmol/l
0.02
332
2958
6
10
6.06
2.70
2.0
2.0
—
—
—
0
0
491
4707
2.01
2.69
21.1
15.2
4.66
4.64
e12/l
0.25
474
4552
215
1795
1.34
2.67
3.4
3.2
0.00
0.00
estimate
0.00
45
362
101
745
1.44
2.65
2.4
2.9
10.93
5.95
e6/l
1.47
83
649
490
4699
1.95
2.61
21.2
15.2
260.59
258.49
e9/l
0.31
476
4550
491
4712
1.98
2.60
21.2
15.3
137.42
137.52
g/l
0.06
485
4651
47
294
1.66
2.59
3.2
3.1
32.06
31.11
%
0.19
34
210
50
319
1.63
2.55
1.3
1.3
230.25
297.32
u/ml
0.30
45
291
82
587
1.47
2.52
3.4
3.1
0.60
0.82
e6/l
0.57
51
322
53
346
1.59
2.47
5.8
7.1
1.19
1.17
mmol/l
0.01
36
243
68
475
1.50
2.36
1.8
1.8
—
—
—
0
0
62
427
1.51
2.30
4.0
4.2
8.62
7.83
umol/l
0.07
53
354
11
41
2.72
2.29
1.1
1.1
—
—
—
0
0
74
531
1.46
2.25
7.3
8.8
1.13
1.19
mmol/l
0.90
68
499
53
355
1.55
2.23
5.9
7.0
5.21
5.10
kpa
0.62
47
330
5
9
5.60
2.22
1.2
1.0
8.60
17.44
u/l
—
5
9
5
9
5.60
2.22
1.0
1.0
—
—
—
0
0
74
533
1.45
2.21
1.3
1.2
18.74
25.63
iu/ml
0.34
17
151
119
934
1.36
2.17
3.3
3.5
0.00
0.00
estimate
0.50
45
367
37
229
1.66
2.15
7.3
14.3
1.13
1.15
inr
—
8
48
8
25
3.23
2.10
1.0
1.1
—
—
—
0
0
105
813
1.37
2.08
1.7
1.6
1.52
1.37
mmol/l
0.65
90
720
5
10
5.04
2.07
1.0
1.0
—
—
—
0
0
401
3729
1.35
2.05
17.5
13.3
13.23
13.20
%
0.19
394
3665
8
26
3.11
2.02
1.0
1.1
—
—
—
0
0
99
765
1.36
1.99
3.1
2.8
1.21
1.03
mg/l
0.26
64
524
5
11
4.58
1.94
2.2
2.5
—
—
—
0
0
40
261
1.58
1.91
1.5
1.3
175.29
268.54
miu/ml
0.88
14
138
55
386
1.48
1.89
3.9
2.6
2572.99
5041.39
u/l
0.54
19
159
11
46
2.42
1.86
1.1
1.1
—
—
—
0
0
52
365
1.47
1.79
1.2
1.3
135.94
128.73
iu/ml
0.05
16
130
76
578
1.37
1.69
4.1
4.5
12.19
14.69
mg/mmol
0.14
51
410
67
500
1.39
1.67
3.4
4.4
486.06
1349.89
ng/l
1.70
54
387
436
4142
1.35
1.65
14.8
11.6
40.42
40.71
%
0.35
346
3541
159
1346
1.26
1.63
3.4
3.2
—
—
—
0
0
8
32
2.52
1.60
1.1
1.0
266.88
302.00
mg/l
—
8
27
61
453
1.39
1.57
4.4
7.7
2.00
1.62
mmol/l
0.58
50
351
47
335
1.44
1.52
1.9
1.7
—
—
—
0
0
15
79
1.93
1.51
1.8
1.4
309.33
319.70
ug/g
—
6
43
46
328
1.44
1.49
1.8
1.7
—
—
—
0
0
25
157
1.62
1.43
3.2
4.4
6.51
6.98
ug/l
0.04
20
124
28
181
1.58
1.43
1.3
1.3
—
—
—
0
0
10
46
2.20
1.40
1.3
1.5
—
—
—
0
0
32
216
1.51
1.37
1.1
1.2
3.81
2.56
u/ml
0.25
20
125
32
216
1.51
1.37
3.7
4.7
1.22
1.23
mmol/l
0.48
26
190
19
113
1.71
1.33
1.1
1.1
1.66
8.18
u/ml
2.54
12
61
17
98
1.76
1.32
1.3
1.2
—
—
—
0
0
21
130
1.64
1.28
1.0
1.1
3.01
6.35
u/ml
0.97
12
63
18
109
1.68
1.20
1.6
1.9
—
—
—
0
0
15
86
1.77
1.20
1.5
1.5
—
—
—
0
0
65
511
1.31
1.20
1.3
1.2
11.17
6.67
u/ml
0.25
25
210
29
198
1.49
1.19
1.1
1.2
3.10
7.69
u/ml
2.10
21
144
15
248
0.59
1.19
1.7
1.6
—
—
—
0
0
67
531
1.30
1.17
3.1
3.2
76.31
883.29
ng/l
2.17
29
301
8
39
2.07
1.15
1.3
1.3
—
—
—
0
0
18
111
1.64
1.13
2.1
2.6
—
—
—
0
0
8
40
2.02
1.12
1.3
1.3
—
—
—
0
0
8
40
2.02
1.12
1.3
1.3
—
—
—
0
0
27
185
1.48
1.11
1.3
1.6
331.38
185.48
u/ml
0.98
13
108
27
187
1.47
1.06
1.4
1.8
4.12
3.28
mg/l
0.33
20
117
38
281
1.38
1.05
3.7
2.8
—
—
—
0
0
14
225
0.61
1.02
1.6
1.7
—
—
—
0
0
94
794
1.23
0.98
2.8
2.3
—
—
—
0
0
145
1277
1.19
0.98
3.3
2.4
—
—
—
0
0
9
50
1.81
0.97
2.3
1.3
4.54
5.39
umol/l
—
9
45
9
51
1.78
0.95
1.1
4.1
—
—
—
0
0
9
51
1.78
0.95
1.6
1.1
—
—
—
0
0
27
193
1.42
0.92
1.2
1.1
0.77
3.41
u/ml
1.72
11
56
27
194
1.41
0.90
1.1
1.2
0.76
1.81
u/ml
0.74
18
125
6
29
2.08
0.89
1.3
1.2
338.00
205.86
iu/ml
—
6
29
34
258
1.34
0.84
1.7
1.8
9.92
13.76
iu/l
0.68
25
199
18
121
1.51
0.83
1.7
2.0
—
—
—
0
0
175
1585
1.16
0.83
2.2
1.9
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
6
32
1.88
0.82
1.0
1.1
—
—
—
0
0
8
47
1.71
0.81
1.1
4.2
33.25
27.00
%
—
8
47
0
24
0.00
0.79
0.0
1.2
—
—
—
0
0
26
191
1.38
0.78
1.3
1.6
—
—
—
0
0
6
34
1.77
0.76
1.8
1.9
—
—
—
0
0
6
34
1.77
0.76
1.0
1.2
—
—
—
0
0
18
124
1.47
0.76
1.7
2.3
40.89
40.76
u/l
0.01
18
115
5
24
2.09
0.74
2.4
2.9
741.40
986.71
u/ml
—
5
24
5
24
2.09
0.74
1.0
1.0
—
—
—
0
0
42
336
1.27
0.73
6.9
7.3
105.45
104.17
mmol/l
1.04
42
331
5
25
2.01
0.73
1.0
1.0
2967.60
1359.44
miu/ml
—
5
25
10
60
1.68
0.72
1.7
1.6
—
—
—
0
0
7
40
1.76
0.71
1.3
1.3
—
—
—
0
0
7
41
1.72
0.70
1.3
1.3
—
—
—
0
0
7
41
1.72
0.70
1.3
1.3
—
—
—
0
0
10
61
1.65
0.69
1.1
2.4
—
—
—
0
0
11
69
1.61
0.69
1.4
1.2
—
25.04
—
0
5
5
27
1.86
0.68
1.2
1.2
104.00
81.67
%
—
5
27
5
27
1.86
0.68
1.2
1.2
—
—
—
0
0
7
121
0.57
0.68
1.4
1.9
—
—
—
0
0
20
145
1.39
0.67
3.0
3.3
0.13
0.12
e6/l
0.07
20
138
5
28
1.79
0.66
1.4
1.3
—
—
—
0
0
26
198
1.33
0.65
1.3
1.2
—
—
—
0
0
41
499
0.81
0.63
1.5
1.5
—
—
—
0
0
10
65
1.55
0.56
1.1
1.2
—
—
—
0
0
26
204
1.29
0.55
1.5
1.3
—
—
—
0
0
17
125
1.37
0.54
1.1
1.1
—
—
—
0
0
20
153
1.32
0.51
1.1
1.1
—
8.16
—
0
25
20
153
1.32
0.51
1.0
1.2
—
—
—
0
0
21
162
1.31
0.51
3.7
3.9
64.93
124.09
ng/l
1.58
14
142
6
41
1.47
0.50
1.0
1.1
—
—
—
0
0
15
200
0.74
0.48
1.4
1.5
—
—
—
0
0
20
155
1.30
0.47
1.0
1.1
—
—
—
0
0
12
85
1.42
0.47
2.1
1.4
—
—
—
0
0
56
488
1.17
0.46
3.5
3.3
1.68
1.63
ug/l
0.04
50
436
7
49
1.43
0.46
1.1
1.1
—
—
—
0
0
25
201
1.26
0.46
1.5
2.7
86.67
81.96
ml/min/173m2
—
9
74
13
95
1.38
0.44
1.6
1.4
—
—
—
0
0
13
95
1.38
0.44
1.6
1.4
—
—
—
0
0
10
70
1.44
0.42
2.0
1.8
—
—
—
0
0
5
34
1.48
0.40
1.8
1.2
—
—
—
0
0
147
1377
1.09
0.39
3.4
2.6
—
—
—
0
0
14
108
1.30
0.35
2.7
2.0
3.05
6.82
iu/l
—
6
37
15
117
1.29
0.35
1.0
1.1
0.09
0.72
u/ml
—
6
40
72
654
1.12
0.35
2.7
2.1
—
—
—
0
0
39
446
0.86
0.35
1.2
1.4
—
—
—
0
0
6
44
1.37
0.34
3.0
1.4
—
—
—
0
0
14
110
1.28
0.32
1.1
1.1
—
—
—
0
0
23
193
1.20
0.31
1.3
1.3
—
—
—
0
0
7
52
1.35
0.31
1.4
1.6
—
—
—
0
0
29
250
1.17
0.30
8.4
9.8
0.88
0.78
mmol/l
0.07
23
190
23
194
1.19
0.30
9.7
10.4
121.52
125.69
g/l
0.47
23
186
7
57
1.23
0.29
2.1
1.8
—
—
—
0
0
9
77
1.17
0.24
1.0
1.1
—
—
—
0
0
41
371
1.11
0.23
2.4
2.2
14.55
13.30
nmol/l
0.23
33
327
5
38
1.32
0.23
1.0
1.2
26.84
18.14
u/l
—
5
33
5
39
1.28
0.23
1.6
1.7
—
—
—
0
0
5
41
1.22
0.22
1.2
1.1
—
—
—
0
0
5
41
1.22
0.22
1.2
1.1
—
—
—
0
0
5
41
1.22
0.22
1.0
1.2
—
—
—
0
0
5
41
1.22
0.22
1.0
1.2
—
—
—
0
0
5
42
1.19
0.21
1.2
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
28.66
—
0
11
0
11
0.00
0.21
0.0
2.5
—
278.20
—
0
5
0
10
0.00
0.21
0.0
1.2
—
9.58
—
0
10
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
5
43
1.16
0.21
2.2
1.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
89
842
1.07
0.20
2.5
2.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
12
99
1.22
0.19
1.3
1.5
—
—
—
0
0
69
648
1.07
0.19
1.6
1.5
—
—
—
0
0
7
60
1.17
0.18
2.0
1.8
—
—
—
0
0
22
247
0.89
0.17
1.5
1.4
—
—
—
0
0
25
278
0.89
0.17
1.6
1.5
—
—
—
0
0
30
273
1.11
0.16
1.6
1.9
5.41
7.22
u/l
1.02
24
206
8
72
1.11
0.16
1.1
2.5
—
—
—
0
0
42
390
1.08
0.16
1.2
1.3
—
—
—
0
0
8
73
1.10
0.15
2.1
1.8
1.39
4.93
ug/l
—
8
67
23
253
0.90
0.14
2.1
1.9
—
—
—
0
0
11
128
0.86
0.13
1.3
1.2
—
—
—
0
0
13
113
1.15
0.13
2.0
1.6
—
—
—
0
0
23
248
0.92
0.09
1.5
1.4
—
—
—
0
0
23
248
0.92
0.09
1.5
1.4
—
—
—
0
0
23
247
0.93
0.09
1.5
1.4
—
—
—
0
0
6
57
1.05
0.08
2.2
1.9
—
—
—
0
0
6
58
1.03
0.08
1.7
1.6
—
—
—
0
0
5
60
0.83
0.08
3.2
1.8
—
—
—
0
0
394
3913
1.03
0.08
4.1
3.8
—
—
—
0
0
5
64
0.78
0.08
1.6
1.5
—
—
—
0
0
39
373
1.05
0.07
3.2
3.2
20.10
22.89
%
—
9
124
9
88
1.02
0.07
1.8
1.8
—
—
—
0
0
24
227
1.06
0.06
1.5
1.4
—
—
—
0
0
27
282
0.96
0.04
3.1
2.2
0.64
0.69
ug/l
0.13
15
139
12
112
1.07
0.03
6.0
4.9
55.77
51.43
%
0.24
12
112
33
323
1.02
0.01
1.5
1.4
—
—
—
0
0
13
125
1.04
0.00
1.2
1.3
—
—
—
0
0
12
116
1.04
0.00
1.4
2.0
206.42
222.35
pmol/l
0.15
12
111
161
1608
1.00
0.00
4.1
4.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
11.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
8
89
0.90
0.00
1.9
1.9
—
—
—
0
0
5
51
0.98
0.00
2.8
1.5
—
—
—
0
0
7
76
0.92
0.00
1.0
1.5
26.96
13.95
u/l
—
7
66
5
52
0.96
0.00
1.4
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint KRA_PSY_TIC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| KRA_PSY_TIC | 1.34 [0.94, 1.92] | 0.111 |
| Birth year | 0.994 [0.99, 1.0] | 0.182 |
During the follow-up period (1.1.1998 — 31.12.2019), 63 out of 2389 females with KRA_PSY_TIC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| KRA_PSY_TIC | 1.569 [1.19, 2.07] | 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.03 |
During the follow-up period (1.1.1998 — 31.12.2019), 92 out of 6900 males with KRA_PSY_TIC died.
Mortality risk
Mortality risk for people of age
years, who have KRA_PSY_TIC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.136% | 0.294% |
| 5 | 0.77% | 1.889% |
| 10 | 1.82% | 4.912% |
| 15 | 3.571% | 9.327% |
| 20 | 6.152% | 15.684% |
Relationships between endpoints
↥Index endpoint: KRA_PSY_TIC – Tic and related disorders
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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