No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
534 |
4. Check minimum number of eventsNone |
534 |
5. Include endpointsNone |
534 |
6. Filter based on genotype QC (FinnGen only) |
499 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF12
- Parent code in ICD-10
- F90-F98
- Name in latin
- Perturbationes ticiformes
Similar endpoints
↥List of similar endpoints to
Tic and related disorders
based on the number of shared cases.
Similar with more cases:
- Tic and related disorders
- Any mental disorder
- Psychiatric diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 12184 | 3427 | 8742 |
| Only index persons | 9944 | 2898 | 7046 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.20 | 0.10 | 0.24 |
| Only index persons | 0.22 | 0.11 | 0.27 |
| Median age at first event (years) | |||
| Whole population | 9.93 | 10.84 | 9.52 |
| Only index persons | 10.81 | 12.11 | 10.28 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 499 | 262 | 237 |
| Unadjusted period prevalence (%) | 0.10 | 0.09 | 0.11 |
| Median age at first event (years) | 15.11 | 17.72 | 12.22 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 534
- Matched controls
- 5340
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
F95.9
ICD-10 Finland
Tic disorder, unspecified
1500.4
212.7
193
*
F95.2
ICD-10 Finland
Combined vocal and multiple motor tic disorder [de la Tourette]
+∞
207.2
185
*
F95.0
ICD-10 Finland
Transient tic disorder
663.1
112.3
107
*
N05AX08
ATC
risperidone; systemic
9.4
108.1
153
218
F95.1
ICD-10 Finland
Chronic motor or vocal tic disorder
+∞
96.9
90
*
N05AD01
ATC
haloperidol; systemic
22.9
84.1
63
31
N05AX12
ATC
aripiprazole; systemic
8.2
76.2
115
173
N03AE01
ATC
clonazepam; systemic
9.8
60.0
74
86
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
4.3
53.2
185
582
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
5.0
34.7
82
186
F42.2
ICD-10 Finland
Mixed obsessional thoughts and acts
10.4
34.3
39
40
ZY010
NOMESCO Finland
Hospital outpatient
4.2
33.2
100
275
N05BA04
ATC
oxazepam; oral
3.2
31.8
169
675
F95.8
ICD-10 Finland
Other tic disorders
+∞
31.6
30
*
N06AB06
ATC
sertraline; oral
3.6
31.4
128
434
F90.0
ICD-10 Finland
Disturbance of activity and attention
3.7
31.3
117
374
30620
ICD-8 Finland
Special symptoms not elsewhere classified, Tics
+∞
30.5
29
*
IBZ01
NOMESCO Finland
Profession-specific psychiatric evaluation
5.3
30.1
65
136
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
4.4
30.1
85
222
N05AH04
ATC
quetiapine; oral
3.1
29.5
171
714
F84.5
ICD-10 Finland
Asperger syndrome
8.8
29.5
38
46
F42.9
ICD-10 Finland
Obsessive-compulsive disorder, unspecified
11.3
28.9
31
29
N05AH03
ATC
olanzapine; systemic
4.3
28.6
83
221
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
4.7
28.3
72
173
N06BA04
ATC
methylphenidate; oral
3.6
27.9
106
341
N06AB03
ATC
fluoxetine; oral
3.7
27.3
100
314
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
4.1
26.9
81
221
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
4.8
26.3
64
148
IBZ06
NOMESCO Finland
Evaluation concerning developmental neuropsychiatry
8.1
25.3
35
46
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
3.9
25.0
81
233
IGY99
NOMESCO Finland
Other psychiatric treatment contact
4.4
24.9
68
172
ZYC01
NOMESCO Finland
Remote contact by phone
4.0
22.7
70
194
N06AX16
ATC
venlafaxine; oral
3.1
22.2
109
408
N05BA01
ATC
diazepam; systemic, rectal
3.5
21.9
83
265
N03AX09
ATC
lamotrigine; oral
4.2
21.8
63
166
IBA04
NOMESCO Finland
Extensive initial psychiatric evaluation
4.3
20.7
57
145
331
Kela drug reimbursment
Atomoxetine, dexamphetamine, guanfacine and lisdexamphetamine
5.1
20.2
44
92
F29
ICD-10 Finland
Unspecified nonorganic psychosis
4.1
20.0
59
158
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
3.5
19.6
74
235
IFA01
NOMESCO Finland
Psychiatric pharmacotherapy plan, not specified
4.8
19.3
45
100
N03AG01
ATC
valproic acid; systemic, rectal
3.9
19.1
60
168
Z2445
NOMESCO Finland
Psychologist
3.2
18.9
82
284
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
2.6
18.6
136
623
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
3.7
18.0
62
185
F42.0
ICD-10 Finland
Predominantly obsessional thoughts or ruminations
7.9
18.0
25
33
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.6
17.8
123
548
3072A
ICD-9 Finland
Special symptoms or syndromes not elsewhere classified, Tics[NYKIMISHÄIRIÖ, MÄÄRITTELEMÄTÖN]
+∞
16.8
16
*
N06AX12
ATC
bupropion; oral
3.1
16.7
79
287
IBA01
NOMESCO Finland
Diagnostic and symptom-mapping evaluation
3.9
16.3
51
142
IGP01
NOMESCO Finland
Psychiatric family contact
4.1
16.0
45
116
N06AB04
ATC
citalopram; systemic
2.8
15.6
91
370
N06AB10
ATC
escitalopram; oral
2.3
15.3
152
792
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.9
15.3
77
289
N06AB05
ATC
paroxetine; oral
4.4
15.3
39
93
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
3.4
15.0
56
176
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
2.8
14.8
84
336
IGY02
NOMESCO Finland
Psychiatric monitoring contact
3.2
14.7
64
221
ICC04
NOMESCO Finland
Psychiatric treatment plan, permanent discontinuation
3.7
14.7
48
138
N05AG02
ATC
pimozide; oral
+∞
14.6
14
*
G24.5
ICD-10 Finland
Blepharospasm
82.4
14.6
16
*
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
5.4
14.5
29
56
IGV01
NOMESCO Finland
Psychiatric network contact
4.6
14.3
35
81
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
6.6
14.2
23
36
ZXY51
NOMESCO Finland
2-person team, doctor-nurse
4.8
14.2
33
73
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
4.2
14.1
39
99
Z3231
NOMESCO Finland
Registered nurse
2.1
14.1
185
1072
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
3.3
14.0
55
178
N06AX11
ATC
mirtazapine; oral
2.1
13.6
165
927
N06AX26
ATC
vortioxetine; oral
2.8
13.6
73
284
C07AA05
ATC
propranolol; systemic
2.2
13.3
131
677
T36
ICD-10 Finland
Poisoning by systemic antibiotics
3.7
13.2
44
128
ICB03
NOMESCO Finland
Psychiatric treatment plan, monitoring
4.2
13.0
35
87
SPAT1240
SPAT
Therapeutic discussion
2.4
12.9
107
512
F42.1
ICD-10 Finland
Predominantly compulsive acts [obsessional rituals]
10.0
12.3
24
25
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
3.4
12.2
45
140
N03AF01
ATC
carbamazepine; oral, rectal
5.2
12.1
25
50
SPAT1243
SPAT
Psychiatric/psychological examination
3.3
12.0
47
152
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.2
11.8
49
164
G51.3
ICD-10 Finland
Clonic hemifacial spasm
66.4
11.6
13
*
Z03.2
ICD-10 Finland
Observation for suspected mental and behavioural disorders
3.9
11.6
35
95
Z2446
NOMESCO Finland
Social worker
2.5
11.6
80
352
ICB02
NOMESCO Finland
Psychiatric treatment plan, extended/prolonged
4.7
11.5
27
60
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.4
11.4
88
407
R42
ICD-10 Finland
Dizziness and giddiness
2.4
11.3
91
429
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
3.8
11.1
34
93
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
5.0
11.1
24
50
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.1
10.9
127
694
N06AA04
ATC
clomipramine; systemic
9.9
10.8
21
22
IEV99
NOMESCO Finland
Other psychiatric network intervention
4.7
10.8
25
55
N03AX12
ATC
[U] gabapentin; oral
2.6
10.7
65
268
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.7
10.6
59
233
F95
ICD-10 Finland
Tic disorders
112.1
10.5
11
*
N05CF01
ATC
zopiclone; oral
2.2
10.4
106
551
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
2.8
10.3
56
218
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
2.8
10.3
53
201
F93.89
ICD-10 Finland
Other childhood emotional disorders
3.8
10.2
32
89
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
4.0
10.1
29
76
N04AA02
ATC
biperiden; systemic
9.0
9.9
20
23
SPAT1307
SPAT
Psychosocial counselling and guidance
2.2
9.7
89
442
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
3.6
9.6
32
93
N06BA09
ATC
atomoxetine; oral
7.1
9.4
22
32
N06BA12
ATC
lisdexamfetamine; oral
3.8
9.3
28
76
N05CD07
ATC
temazepam; oral
3.5
9.2
32
96
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
3.1
9.2
40
138
F33.00
ICD-10 Finland
Recurrent depression, mild episode without somatic syndrome
4.1
9.2
25
63
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
3.1
9.1
38
128
F83
ICD-10 Finland
Mixed specific developmental disorders
3.7
9.1
29
82
ZXE01
NOMESCO Finland
Procedure duration 0 to 9 minutes
4.3
9.0
23
55
N03AX16
ATC
[U] pregabalin
2.2
8.9
78
380
R56.8
ICD-10 Finland
Other and unspecified convulsions
2.6
8.8
51
205
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
2.0
8.8
101
547
Z00.8
ICD-10 Finland
Other general examinations
2.4
8.8
62
275
F33.4
ICD-10 Finland
Recurrent depressive disorder, currently in remission
3.7
8.5
27
76
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
3.4
8.5
31
96
T82
ICPC
Obesity
3.4
8.5
30
91
L01
ICPC
Neck symptom/complaint
2.1
8.4
90
474
N06AX21
ATC
duloxetine; oral
2.5
8.4
57
248
J45.9
ICD-10 Finland
Asthma, unspecified
2.0
8.4
97
526
N06AA09
ATC
amitriptyline; systemic
3.4
8.3
30
92
P99
ICPC
Psychological disorders other
3.4
8.3
30
92
F32.00
ICD-10 Finland
Mild depressive episode without somatic syndrome
2.9
8.2
38
136
F45.8
ICD-10 Finland
Other somatoform disorders
2.5
8.1
53
227
F92.8
ICD-10 Finland
Other mixed disorders of conduct and emotions
10.3
8.1
15
15
R53
ICD-10 Finland
Malaise and fatigue
1.9
8.1
128
772
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
2.6
8.1
46
184
R25.3
ICD-10 Finland
Fasciculation
22.4
8.0
11
5
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
7.9
110
635
ZXE20
NOMESCO Finland
More than three and less than five hours
2.3
7.9
62
288
F98.8
ICD-10 Finland
Other specified behavioural and emotional disorders with onset usually occurring in childhood and adolescence
7.1
7.8
18
26
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
2.7
7.8
42
163
P29
ICPC
Psychological sympt/compl other
2.1
7.8
79
407
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
3.0
7.7
34
118
G24.9
ICD-10 Finland
Dystonia, unspecified
45.7
7.7
9
*
XA800
NOMESCO Finland
Neuropsychological investigation
2.6
7.6
44
177
IFA99
NOMESCO Finland
Other psychiatric pharmacotherapy service
4.0
7.5
21
54
F80.1
ICD-10 Finland
Expressive language disorder
3.5
7.5
25
73
F41.8
ICD-10 Finland
Other specified anxiety disorders
2.8
7.4
37
138
F99
ICD-10 Finland
Mental disorder, not otherwise specified
3.6
7.3
24
69
H53.1
ICD-10 Finland
Subjective visual disturbances
2.8
7.3
36
133
P27
ICPC
Fear of mental disorder
3.7
7.2
23
65
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
7.2
202
1427
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.2
7.2
62
300
SPAT1058
SPAT
PEF monitoring instruction
2.7
7.1
39
153
F84.8
ICD-10 Finland
Other pervasive developmental disorders
9.0
7.1
14
16
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.8
7.0
36
136
N05BE01
ATC
buspirone; oral
4.0
7.0
20
52
M03BX01
ATC
baclofen; systemic
6.5
7.0
17
27
ZXY82
NOMESCO Finland
Nurse in multidisciplinary team
6.5
7.0
17
27
N05AF03
ATC
chlorprothixene; systemic
4.1
6.9
19
48
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.9
6.9
99
575
N05AF01
ATC
flupentixol; systemic
14.0
6.9
11
8
F84.9
ICD-10 Finland
Pervasive developmental disorder, unspecified
6.8
6.9
16
24
P76
ICPC
Depressive disorder
2.3
6.8
55
258
N05AB03
ATC
perphenazine; systemic, rectal
3.7
6.8
21
58
N02BF02
ATC
pregabalin; oral
3.0
6.8
29
99
SPAT1395
SPAT
Health check-up of persons outside student and working life
4.4
6.8
17
40
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.2
6.8
56
266
N05BA06
ATC
lorazepam; systemic, sublingual
3.5
6.8
23
68
P10
ICPC
Stammering/stuttering/tic
17.0
6.8
10
6
R25.8
ICD-10 Finland
Other and unspecified abnormal involuntary movements
17.0
6.8
10
6
SPAT1389
SPAT
Visit based on need for special support
2.2
6.7
57
274
D01
ICPC
Abdominal pain/cramps general
1.9
6.6
98
576
F84.0
ICD-10 Finland
Childhood autism
12.4
6.6
11
9
Z76.0
ICD-10 Finland
Issue of repeat prescription
1.8
6.6
122
767
G47.3
ICD-10 Finland
Sleep apnoea
2.0
6.6
72
382
P03
ICPC
Feeling depressed
1.8
6.6
100
593
P74
ICPC
Anxiety disorder/anxiety state
2.3
6.5
52
243
R03AC02
ATC
salbutamol; inhalant
1.6
6.4
290
2287
F61.0
ICD-10 Finland
Mixed personality disorders
5.6
6.3
17
31
SPAT1365
SPAT
Health check-up performed during first study year due to special need in students of upper secondary schools or vocational schools
6.1
6.3
16
27
ZY000
NOMESCO Finland
Hospital inpatient
3.8
6.2
19
52
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
2.6
6.2
36
145
F50.9
ICD-10 Finland
Eating disorder, unspecified
3.6
6.2
20
57
SPAT1241
SPAT
Extensive assessment of psychosocial situation
4.1
6.2
17
43
F90.9
ICD-10 Finland
Hyperkinetic disorder, unspecified
3.4
6.2
22
67
F88
ICD-10 Finland
Other disorders of psychological development
6.4
6.2
15
24
F34.1
ICD-10 Finland
Dysthymia
2.9
6.2
28
99
F92.9
ICD-10 Finland
Mixed disorder of conduct and emotions, unspecified
5.9
6.2
16
28
N05BA12
ATC
alprazolam; oral
2.5
6.2
38
158
Z76.8
ICD-10 Finland
Persons encountering health services in other specified circumstances
2.9
6.2
29
105
SPAT1260
SPAT
Consultation of another employee
1.9
6.1
90
527
IBA03
NOMESCO Finland
Psychotherapy evaluation
4.0
6.0
17
44
R4110
NOMESCO Finland
Physiotherapy
1.7
6.0
125
810
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
185
1013
2.26
16.78
2.7
3.0
2.37
2.37
mmol/l
0.30
163
914
412
3121
2.40
16.25
4.3
3.6
14.46
14.52
pmol/l
0.22
378
2830
138
692
2.34
15.20
2.5
1.6
1.51
1.39
%
1.30
123
637
237
1536
1.98
13.02
2.6
2.7
68.27
70.13
nmol/l
0.48
228
1418
181
1076
2.03
12.63
1.9
1.6
100.08
98.69
pmol/l
0.17
100
547
446
3657
2.33
12.13
5.2
4.1
1.88
1.85
mu/l
0.24
425
3412
410
3269
2.09
11.72
3.8
3.0
5.62
5.60
mmol/l
0.14
388
3000
348
2628
1.93
11.55
7.0
6.3
87.36
86.40
u/l
0.11
329
2472
200
1273
1.91
11.19
3.4
3.3
27.57
32.66
u/l
2.60
191
1206
462
3896
2.38
10.90
14.1
11.0
139.52
139.55
mmol/l
0.12
456
3760
99
497
2.22
10.57
1.6
1.6
445.58
15473888.01
pmol/l
0.50
85
433
113
599
2.12
10.51
1.6
1.3
18.46
19.91
nmol/l
0.60
102
518
240
1647
1.83
10.40
7.7
7.8
1.22
1.22
mmol/l
0.34
210
1429
461
3907
2.32
10.36
14.2
11.0
3.92
3.92
mmol/l
0.08
453
3754
234
1602
1.82
10.15
5.9
6.0
11.24
11.58
umol/l
0.11
222
1501
140
814
1.98
10.08
2.9
2.3
167.58
376.91
u/l
1.45
132
767
355
2767
1.84
9.89
4.4
3.7
8.91
8.22
mm/h
0.45
328
2557
194
1286
1.80
9.15
4.8
5.9
37.93
37.61
g/l
0.34
183
1207
162
1019
1.85
9.06
3.6
3.7
9.00
8.86
mmol/l
0.10
142
921
299
2255
1.74
8.90
6.9
7.3
31.69
31.84
%
0.09
286
2156
81
402
2.20
8.83
1.7
1.7
1090.01
1139.67
nmol/l
0.21
66
309
97
518
2.07
8.75
5.9
7.5
0.85
0.81
mmol/l
1.24
90
487
291
2217
1.69
8.01
6.8
7.2
53.07
53.67
%
0.37
279
2117
322
2520
1.70
8.01
10.5
9.6
3.74
3.87
e9/l
0.55
281
2169
153
987
1.77
7.69
2.7
2.6
51.94
57.25
u/l
0.63
143
908
215
1526
1.68
7.64
6.7
7.8
1.22
1.22
mmol/l
0.17
201
1417
343
2751
1.69
7.58
4.1
3.1
30.71
33.88
u/l
0.83
325
2630
138
876
1.78
7.28
2.9
3.2
1.02
1.02
kg/l
0.05
14
118
140
924
1.70
6.33
3.6
2.9
30.74
39.57
ng/l
0.22
71
440
258
2010
1.55
5.77
3.1
3.0
75.35
72.16
ug/l
0.15
242
1876
475
4300
1.95
5.59
10.5
8.2
27.53
27.53
u/l
0.00
465
4156
16
42
3.90
5.57
1.0
1.1
—
—
—
0
0
304
2470
1.54
5.51
4.6
3.9
6074.80
557.41
e6/l
—
5
29
173
1249
1.57
5.33
3.3
3.6
—
—
—
0
0
262
2085
1.50
5.09
4.4
5.1
6.20
6.36
mmol/l
0.68
237
1889
137
948
1.60
5.02
2.9
2.6
2.72
2.73
mg/l
0.03
119
816
159
1143
1.56
4.94
5.6
7.6
1.09
1.12
inr
0.26
56
380
42
209
2.10
4.56
1.8
1.6
—
—
—
0
0
389
3421
1.50
4.21
3.5
3.2
4.48
4.56
mmol/l
0.82
373
3238
386
3399
1.49
4.06
3.4
3.1
1.38
1.41
mmol/l
0.68
365
3206
389
3440
1.48
3.93
3.7
3.3
2.74
2.77
mmol/l
0.28
370
3224
58
342
1.78
3.85
1.3
1.3
235.83
307.83
u/ml
0.35
53
311
186
1442
1.44
3.84
1.5
1.6
0.59
2.25
u/ml
2.70
43
321
10
19
5.34
3.84
3.0
3.3
15.89
19.88
ug/l
—
10
19
377
3320
1.46
3.83
12.7
8.6
100.72
100.43
ml/min/173m2
0.08
306
2498
11
24
4.66
3.76
1.3
2.5
11.03
16.60
umol/l
1.11
11
24
23
98
2.41
3.62
1.6
1.5
—
—
—
0
0
333
2882
1.41
3.61
4.4
4.0
36.88
37.49
mmol/mol
0.54
317
2729
230
1870
1.40
3.59
4.8
4.5
0.00
0.00
estimate
-0.00
47
390
72
465
1.63
3.45
2.9
2.7
2.42
2.42
mmol/l
0.08
66
395
231
1890
1.39
3.43
3.6
3.3
0.00
0.00
estimate
-0.00
45
372
67
428
1.65
3.35
1.1
1.0
—
—
—
0
0
8
14
5.78
3.35
1.0
1.1
—
—
—
0
0
8
14
5.78
3.35
1.0
1.1
—
—
—
0
0
48
281
1.78
3.29
6.0
5.9
—
—
—
0
0
458
4239
1.57
3.26
14.2
10.5
19.04
21.89
mg/l
1.38
346
3058
139
1048
1.44
3.26
3.4
3.4
0.31
0.25
e6/l
0.27
107
776
59
370
1.67
3.17
2.1
2.4
182.24
31.12
u/l
0.48
49
308
365
3247
1.39
3.12
3.3
3.0
1.22
1.21
mmol/l
0.05
345
3053
81
556
1.54
3.01
1.4
1.2
17.92
24.58
iu/ml
0.35
18
164
14
51
2.79
3.00
1.0
1.1
—
—
—
0
0
37
206
1.86
2.99
1.6
1.7
—
—
—
0
0
67
441
1.59
2.99
4.1
4.1
8.38
7.78
umol/l
0.06
58
362
49
300
1.70
2.89
3.2
3.1
32.06
31.06
%
0.21
36
221
7
13
5.44
2.87
1.0
1.0
—
—
—
0
0
7
13
5.44
2.87
1.0
1.0
—
—
—
0
0
7
13
5.44
2.87
1.0
1.2
—
—
—
0
0
512
4907
2.05
2.87
21.1
15.3
40.63
41.67
%
0.54
487
4699
225
1875
1.35
2.83
3.4
3.2
0.00
0.00
estimate
-0.00
45
386
17
71
2.44
2.83
1.3
1.2
—
—
—
0
0
11
33
3.38
2.82
3.9
2.5
40036.36
41578.94
ug/l
0.12
11
33
512
4912
2.03
2.77
21.0
15.1
4.66
4.64
e12/l
0.23
494
4748
49
304
1.67
2.76
5.4
8.0
1.48
1.48
mmol/l
0.00
49
290
512
4916
2.01
2.70
21.2
15.3
137.13
137.35
g/l
0.13
506
4853
511
4904
1.98
2.69
21.1
15.2
261.26
258.71
e9/l
0.41
496
4745
12
43
2.83
2.66
1.1
1.1
—
—
—
0
0
105
780
1.43
2.64
2.4
2.9
10.43
6.19
e6/l
1.27
89
687
40
238
1.74
2.63
1.1
1.2
2.88
3.46
u/ml
0.14
28
164
6
11
5.50
2.55
2.0
2.1
—
—
—
0
0
84
603
1.47
2.53
3.5
3.1
2.04
3.04
e6/l
0.91
54
325
86
622
1.46
2.49
3.3
3.0
0.60
0.79
e6/l
0.49
55
341
13
51
2.59
2.46
1.1
1.1
—
—
—
0
0
124
966
1.37
2.36
3.3
3.5
0.00
0.00
estimate
0.50
45
379
105
796
1.40
2.35
3.0
2.8
1.17
1.06
mg/l
0.16
68
545
28
156
1.84
2.30
1.6
1.6
—
—
—
0
0
47
304
1.60
2.28
2.1
1.8
—
—
—
0
0
70
498
1.47
2.22
1.8
1.8
—
—
—
0
0
5
9
5.60
2.22
1.2
1.0
8.60
17.44
u/l
—
5
9
72
516
1.46
2.20
3.2
4.5
475.56
1328.99
ng/l
1.77
57
402
15
67
2.27
2.19
1.2
1.6
—
—
—
0
0
36
220
1.68
2.18
1.1
1.2
3.96
7.17
u/ml
1.17
26
162
109
845
1.36
2.13
1.7
1.6
1.53
1.38
mmol/l
0.70
93
750
77
564
1.43
2.10
7.2
8.8
1.13
1.19
mmol/l
1.13
71
530
5
10
5.04
2.07
1.0
1.0
—
—
—
0
0
57
396
1.49
2.04
3.8
2.6
2444.49
5204.82
u/l
0.66
20
164
56
388
1.50
2.03
5.8
7.0
1.20
1.12
mmol/l
0.09
37
274
9
32
2.84
2.01
1.1
1.0
256.11
302.00
mg/l
—
9
27
424
3963
1.34
2.00
17.6
13.3
13.83
13.75
%
0.15
419
3898
168
1399
1.29
1.99
3.4
3.2
—
—
—
0
0
5
11
4.58
1.94
1.0
1.0
—
—
—
0
0
8
27
2.99
1.94
1.0
1.1
—
—
—
0
0
54
378
1.48
1.87
1.2
1.3
134.89
128.45
iu/ml
0.05
17
132
67
490
1.42
1.85
4.2
7.4
1.96
1.54
mmol/l
0.75
54
381
34
215
1.62
1.84
1.1
1.2
0.69
1.75
u/ml
0.89
22
138
56
397
1.46
1.83
5.9
6.9
5.18
5.07
kpa
0.61
50
377
5
12
4.20
1.82
2.2
2.4
—
—
—
0
0
71
527
1.40
1.81
1.4
1.2
10.81
7.11
u/ml
0.20
26
216
8
29
2.78
1.79
1.0
1.1
—
—
—
0
0
79
603
1.36
1.71
3.8
4.3
12.19
14.39
mg/mmol
0.12
51
429
34
221
1.58
1.67
3.7
4.6
1.22
1.23
mmol/l
0.61
27
195
11
49
2.27
1.64
1.1
1.1
—
—
—
0
0
40
272
1.51
1.62
1.5
1.3
175.29
266.65
miu/ml
0.86
14
140
33
215
1.57
1.61
1.2
1.1
2.57
2.75
u/ml
0.04
24
151
29
184
1.61
1.58
1.3
1.3
—
—
—
0
0
20
115
1.77
1.54
1.9
2.5
—
—
—
0
0
16
86
1.89
1.52
1.7
1.4
317.57
330.34
ug/g
—
7
48
11
53
2.10
1.39
1.5
1.1
—
—
—
0
0
19
112
1.72
1.37
1.6
1.9
—
—
—
0
0
11
54
2.06
1.33
1.2
4.1
12.82
9.41
%
0.52
11
54
48
353
1.40
1.33
1.8
1.7
—
—
—
0
0
47
345
1.40
1.32
1.8
1.7
—
—
—
0
0
10
48
2.10
1.28
1.3
1.5
—
—
—
0
0
25
162
1.57
1.28
3.2
4.3
6.51
6.85
ug/l
0.03
20
127
15
253
0.58
1.27
1.7
1.6
—
—
—
0
0
23
147
1.59
1.25
1.0
1.1
4.22
5.53
u/ml
0.29
15
92
13
70
1.88
1.25
1.4
1.2
—
25.04
—
0
5
20
124
1.64
1.22
1.6
2.0
—
—
—
0
0
70
559
1.29
1.15
3.1
3.2
275.45
883.31
ng/l
1.19
31
316
14
233
0.59
1.14
1.6
1.7
—
—
—
0
0
17
103
1.67
1.14
1.3
1.2
—
—
—
0
0
8
40
2.01
1.12
1.3
1.3
—
—
—
0
0
15
88
1.72
1.12
1.5
1.5
—
—
—
0
0
5
21
2.39
1.09
2.0
1.5
73.60
71.90
umol/l
—
5
21
8
41
1.97
1.09
1.3
1.2
—
—
—
0
0
8
41
1.97
1.09
1.3
1.2
—
—
—
0
0
46
350
1.34
1.07
6.5
7.1
105.70
104.23
mmol/l
1.38
46
350
21
138
1.54
1.04
10.4
10.6
24.40
24.08
mmol/l
0.32
21
133
20
130
1.56
1.04
1.1
1.1
1.66
7.85
u/ml
2.74
12
72
11
61
1.82
0.99
1.1
2.4
—
—
—
0
0
97
822
1.22
0.98
2.7
2.3
—
—
—
0
0
149
1315
1.18
0.97
3.2
2.4
—
—
—
0
0
28
200
1.42
0.95
1.3
1.7
325.57
181.27
u/ml
1.07
14
113
22
150
1.49
0.94
3.1
3.2
0.12
0.13
e6/l
0.03
22
143
7
126
0.55
0.89
1.4
1.8
—
—
—
0
0
27
195
1.41
0.88
1.4
1.7
3.96
3.30
mg/l
0.26
21
125
6
30
2.01
0.87
1.3
1.2
338.00
207.07
iu/ml
—
6
30
37
284
1.33
0.84
3.8
2.7
—
—
—
0
0
11
65
1.71
0.83
1.6
1.6
—
—
—
0
0
8
47
1.71
0.81
1.1
4.2
33.25
27.00
%
—
8
47
35
269
1.32
0.80
1.7
1.8
10.08
13.46
iu/l
0.58
25
206
6
33
1.83
0.79
1.8
1.8
—
—
—
0
0
0
26
0.00
0.78
0.0
1.2
—
—
—
0
0
6
34
1.77
0.76
1.0
1.2
—
—
—
0
0
6
34
1.77
0.76
1.7
1.2
—
—
—
0
0
9
53
1.71
0.75
1.1
4.1
—
—
—
0
0
5
24
2.09
0.74
2.4
2.9
741.40
986.71
u/ml
—
5
24
5
25
2.01
0.73
1.0
1.0
2967.60
1359.44
miu/ml
—
5
25
9
56
1.62
0.72
2.3
1.3
4.54
5.19
umol/l
—
9
51
5
26
1.93
0.71
1.0
1.0
—
—
—
0
0
7
41
1.72
0.70
1.3
1.3
—
—
—
0
0
9
59
1.53
0.68
1.9
1.8
—
—
—
0
0
7
42
1.68
0.68
1.3
1.3
—
—
—
0
0
7
42
1.68
0.68
1.3
1.3
—
—
—
0
0
27
206
1.33
0.67
1.3
1.6
—
—
—
0
0
42
513
0.80
0.66
1.5
1.5
—
—
—
0
0
18
128
1.42
0.66
1.7
2.2
39.78
40.88
u/l
0.11
18
119
5
29
1.73
0.64
6.4
3.6
23.60
26.93
umol/l
—
5
29
11
71
1.56
0.62
1.9
1.8
—
—
—
0
0
5
30
1.67
0.61
1.2
1.2
104.00
81.10
%
—
5
30
181
1674
1.12
0.61
2.2
1.9
—
—
—
0
0
32
256
1.27
0.58
8.1
9.8
0.84
0.80
mmol/l
0.03
25
197
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
6
35
1.72
0.58
1.0
1.1
—
—
—
0
0
15
206
0.72
0.56
1.4
1.5
—
—
—
0
0
14
99
1.43
0.54
1.6
1.4
—
—
—
0
0
14
99
1.43
0.54
1.6
1.4
—
—
—
0
0
10
66
1.52
0.53
1.1
1.2
—
—
—
0
0
58
501
1.18
0.52
3.6
3.3
1.63
1.61
ug/l
0.02
52
449
27
215
1.27
0.52
1.3
1.2
—
—
—
0
0
7
45
1.56
0.49
2.7
1.4
—
—
—
0
0
17
128
1.34
0.48
1.1
1.1
—
—
—
0
0
27
218
1.25
0.47
1.5
1.3
—
—
—
0
0
20
156
1.29
0.45
1.0
1.1
—
—
—
0
0
7
50
1.41
0.45
1.1
1.1
—
—
—
0
0
17
130
1.32
0.44
1.0
1.1
0.13
0.60
u/ml
—
8
56
5
31
1.62
0.43
1.4
1.3
—
—
—
0
0
17
131
1.31
0.42
2.2
5.5
0.70
0.69
%
0.04
17
131
25
204
1.24
0.41
1.5
2.6
86.67
81.84
ml/min/173m2
—
9
76
0
15
0.00
0.41
0.0
1.4
—
—
—
0
0
20
159
1.27
0.40
1.0
1.2
—
—
—
0
0
40
463
0.85
0.40
1.2
1.4
—
—
—
0
0
22
178
1.25
0.39
3.6
3.9
87.33
143.70
ng/l
0.83
15
158
12
89
1.36
0.38
2.1
1.4
—
—
—
0
0
15
116
1.30
0.37
1.1
1.1
—
—
—
0
0
151
1420
1.09
0.37
3.4
2.5
—
—
—
0
0
6
43
1.40
0.35
1.0
1.1
—
—
—
0
0
14
109
1.29
0.33
2.7
2.0
3.05
6.82
iu/l
—
6
37
74
676
1.11
0.33
2.6
2.1
—
—
—
0
0
24
201
1.20
0.33
9.6
10.3
121.38
125.53
g/l
0.50
24
193
20
165
1.22
0.31
1.1
1.1
—
9.03
—
0
30
7
56
1.25
0.29
1.4
1.6
—
—
—
0
0
13
103
1.27
0.28
1.4
1.5
—
—
—
0
0
8
64
1.25
0.27
1.9
1.8
—
—
—
0
0
24
206
1.17
0.26
1.3
1.3
—
—
—
0
0
9
75
1.20
0.25
1.1
2.4
—
—
—
0
0
22
255
0.86
0.25
1.5
1.4
—
—
—
0
0
5
39
1.28
0.23
1.0
1.2
26.84
17.92
u/l
—
5
34
14
116
1.21
0.22
5.6
4.7
58.78
51.40
%
0.52
14
116
14
116
1.21
0.22
1.9
1.6
—
—
—
0
0
42
382
1.11
0.22
2.4
2.3
12.77
12.74
nmol/l
0.01
36
353
72
673
1.08
0.22
1.6
1.5
—
—
—
0
0
5
42
1.19
0.21
1.6
1.7
—
—
—
0
0
0
11
0.00
0.21
0.0
2.5
—
145.27
—
0
11
0
10
0.00
0.21
0.0
1.2
—
9.59
—
0
10
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
27.02
—
0
12
5
43
1.16
0.21
1.2
1.1
—
—
—
0
0
5
43
1.16
0.21
1.0
1.2
—
—
—
0
0
5
43
1.16
0.21
1.2
1.1
—
—
—
0
0
5
43
1.16
0.21
1.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
6
50
1.20
0.19
2.3
2.3
—
—
—
0
0
92
874
1.06
0.19
2.4
2.5
—
—
—
0
0
7
58
1.21
0.18
2.0
1.9
—
—
—
0
0
7
60
1.17
0.18
1.6
1.5
—
—
—
0
0
11
131
0.84
0.17
1.3
1.2
—
—
—
0
0
5
70
0.71
0.17
1.6
1.5
—
—
—
0
0
23
256
0.89
0.16
1.5
1.4
—
—
—
0
0
23
256
0.89
0.16
1.5
1.4
—
—
—
0
0
23
256
0.89
0.16
1.5
1.4
—
—
—
0
0
26
286
0.90
0.15
1.5
1.5
—
—
—
0
0
9
79
1.14
0.15
1.0
1.1
—
—
—
0
0
70
667
1.06
0.14
4.6
3.3
319.65
3056.81
umol/l
1.57
65
603
15
132
1.14
0.13
1.3
1.3
—
—
—
0
0
24
261
0.92
0.12
2.1
1.9
—
—
—
0
0
5
44
1.14
0.10
1.2
1.2
—
—
—
0
0
5
45
1.11
0.10
2.2
1.6
—
—
—
0
0
7
65
1.08
0.08
2.0
1.8
—
—
—
0
0
7
65
1.08
0.08
2.0
1.8
—
—
—
0
0
8
74
1.08
0.07
2.1
1.8
1.39
4.93
ug/l
—
8
67
25
235
1.07
0.07
1.5
1.4
—
—
—
0
0
7
80
0.87
0.07
1.0
1.5
26.96
15.85
u/l
—
7
70
411
4086
1.03
0.07
4.1
3.9
—
—
—
0
0
169
1665
1.02
0.06
2.7
2.7
—
—
—
0
0
28
294
0.95
0.06
3.1
2.2
0.62
0.69
ug/l
0.18
16
144
40
385
1.04
0.06
3.2
3.1
20.10
23.04
%
—
9
126
30
288
1.04
0.04
1.6
1.9
5.48
7.15
u/l
0.89
23
214
11
119
0.92
0.04
1.4
2.0
205.09
222.09
pmol/l
0.15
11
114
42
409
1.03
0.03
1.2
1.3
—
—
—
0
0
10
93
1.08
0.02
1.7
1.8
—
—
—
0
0
13
123
1.06
0.01
4.7
4.5
24.40
24.71
mmol/l
0.18
13
118
12
124
0.97
0.00
4.3
10.2
24.99
24.22
mmol/l
0.45
12
114
33
335
0.98
0.00
1.5
1.4
—
—
—
0
0
5
51
0.98
0.00
5.8
5.3
1.87
1.93
ug/l
—
5
51
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
5
55
0.91
-0.00
1.4
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
94
0.96
-0.00
1.8
1.9
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
6.33
—
0
7
5
53
0.94
-0.00
2.8
1.5
—
—
—
0
0
5
54
0.93
-0.00
2.4
1.9
—
—
—
0
0
6
63
0.95
-0.00
2.8
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
10.8
—
—
—
0
0
5
54
0.93
-0.00
2.4
1.9
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint KRA_PSY_TIC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| KRA_PSY_TIC | 1.34 [0.94, 1.92] | 0.111 |
| Birth year | 0.994 [0.99, 1.0] | 0.182 |
During the follow-up period (1.1.1998 — 31.12.2019), 63 out of 2389 females with KRA_PSY_TIC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| KRA_PSY_TIC | 1.569 [1.19, 2.07] | 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.03 |
During the follow-up period (1.1.1998 — 31.12.2019), 92 out of 6900 males with KRA_PSY_TIC died.
Mortality risk
Mortality risk for people of age
years, who have KRA_PSY_TIC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.136% | 0.294% |
| 5 | 0.77% | 1.889% |
| 10 | 1.82% | 4.912% |
| 15 | 3.571% | 9.327% |
| 20 | 6.152% | 15.684% |
Relationships between endpoints
↥Index endpoint: KRA_PSY_TIC – Tic and related disorders
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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