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Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx, excluding all cancers (controls excluding all cancers)

C3_LIP_ORAL_PHARYNX_NAS_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C14
  • Hospital discharge: ICD-9 149
  • Hospital discharge: ICD-8 149
  • Cause of death: ICD-10 C14
  • Cause of death: ICD-9 149
  • Cause of death: ICD-8 149
  • Cancer registry: Topography ICD-O-3 C14
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

85

4. Check minimum number of events

None

85

5. Include endpoints

None

85

6. Filter based on genotype QC (FinnGen only)

85

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12

Similar endpoints

List of similar endpoints to Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx, excluding all cancers (controls excluding all cancers) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 85 19 66
Unadjusted period prevalence (%) 0.02 0.01 0.03
Median age at first event (years) 67.29 65.01 67.95

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
25
20
17.29
26.69
1.6
1.4
—
—
—
0
0
21
32
8.39
13.92
2.9
1.3
0.2
0.2
g/l
0.68
21
24
44
172
4.23
9.93
3.3
1.6
—
—
—
0
0
39
147
4.05
9.12
4.2
4.1
—
—
—
0
0
28
87
4.31
8.45
7.7
2.8
0.8
0.8
mmol/l
3.28
28
81
56
299
3.56
7.28
13.9
6.2
4.3
4.2
e9/l
0.10
51
251
38
164
3.38
6.91
3.7
2.2
—
—
—
0
0
48
239
3.32
6.89
6.4
8.9
1.4
1.4
inr
0.04
12
66
23
75
3.83
6.35
2.4
1.9
—
—
—
0
0
16
43
4.35
5.68
1.6
1.1
—
—
—
0
0
23
84
3.38
5.30
2.0
1.8
—
—
—
0
0
37
184
2.79
4.95
5.2
5.5
—
—
—
0
0
10
25
4.40
3.82
10.4
7.3
—
—
—
0
0
44
267
2.34
3.63
6.1
5.5
0.7
0.6
e9/l
0.74
39
225
44
267
2.34
3.63
7.0
5.5
0.0
0.0
e9/l
0.45
39
229
42
251
2.33
3.57
6.5
5.6
64.4
57.5
%
2.55
37
227
42
252
2.32
3.53
5.5
5.8
22.8
27.2
%
1.48
37
224
5
6
8.75
2.78
1.0
1.3
—
—
—
0
0
20
100
2.31
2.46
2.0
2.3
2.5
2.4
mmol/l
0.95
14
78
15
68
2.46
2.27
9.1
6.2
1.5
1.8
mmol/l
—
9
54
20
107
2.14
2.08
4.6
4.8
—
—
—
0
0
26
154
1.99
2.08
5.5
3.6
7.4
7.4
ph
—
5
25
14
65
2.38
2.01
1.3
1.5
—
—
—
0
0
23
136
1.95
1.83
1.4
1.3
—
—
—
0
0
8
30
2.84
1.77
8.5
7.3
24.9
25.1
mmol/l
—
8
30
21
122
1.96
1.75
2.0
2.0
9.3
5.1
e6/l
0.41
16
108
5
14
3.72
1.64
2.2
1.7
—
—
—
0
0
19
109
1.96
1.64
1.8
2.4
428.2
560.4
mosm/kgh2o
1.79
14
88
20
120
1.87
1.51
10.8
5.0
—
—
—
0
0
7
29
2.54
1.42
3.4
2.3
—
—
—
0
0
69
596
1.84
1.36
25.6
12.5
32.0
24.9
mg/l
1.16
59
453
26
179
1.65
1.23
2.7
2.7
110.3
389.7
e6/l
0.34
19
135
50
590
0.63
1.22
5.2
6.3
39.6
41.5
mmol/mol
0.96
43
543
7
30
2.45
1.15
1.4
1.8
10.8
9.1
g/l
—
7
25
53
614
0.64
1.14
4.7
5.4
2.7
2.6
mmol/l
0.42
47
558
9
47
2.02
1.06
8.1
3.6
—
—
—
0
0
24
168
1.60
1.05
2.8
2.6
1.3
0.3
e6/l
0.52
18
121
51
423
1.51
1.04
5.1
3.7
14.0
15.1
pmol/l
1.69
45
373
10
54
1.97
1.01
2.8
3.2
—
—
—
0
0
23
161
1.59
1.01
2.7
2.5
—
—
—
0
0
10
55
1.93
0.97
2.9
2.4
—
—
—
0
0
15
223
0.60
0.96
4.3
4.2
10.8
12.2
mg/mmol
—
9
138
7
37
1.97
0.96
2.7
2.3
—
—
—
0
0
7
37
1.97
0.96
4.7
3.5
1.3
1.2
mmol/l
—
7
32
11
63
1.86
0.95
2.0
3.9
—
—
—
0
0
6
28
2.23
0.93
1.2
1.1
—
—
—
0
0
27
200
1.51
0.92
2.9
3.2
240.3
67.7
e6/l
0.48
20
144
20
140
1.56
0.87
3.9
2.8
—
—
—
0
0
11
65
1.80
0.87
1.0
1.6
—
—
—
0
0
8
45
1.86
0.87
1.0
1.3
—
—
—
0
0
8
45
1.86
0.87
1.0
1.6
—
—
—
0
0
8
48
1.73
0.81
9.0
8.6
—
—
—
0
0
6
34
1.82
0.78
2.7
5.0
25.0
25.2
mmol/l
—
6
27
5
23
2.24
0.77
1.8
1.4
—
—
—
0
0
69
628
1.52
0.75
23.2
12.0
—
—
—
0
0
53
594
0.71
0.72
3.9
4.8
1.5
1.4
mmol/l
0.68
46
540
7
42
1.73
0.70
2.3
2.4
120.7
126.3
g/l
—
7
42
52
453
1.38
0.69
4.9
4.0
—
—
—
0
0
7
43
1.68
0.68
1.0
1.2
—
—
—
0
0
16
217
0.68
0.66
2.6
3.3
6.6
7.6
mmol/l
0.71
16
182
54
599
0.73
0.64
4.3
4.8
4.7
4.5
mmol/l
0.58
48
547
5
30
1.71
0.62
10.6
8.2
25.6
25.6
mmol/l
—
5
25
30
243
1.36
0.62
10.4
8.6
0.0
0.0
e9/l
0.00
25
200
0
20
0.00
0.61
0.0
1.4
—
—
—
0
0
12
81
1.56
0.61
1.3
1.2
—
—
—
0
0
6
38
1.62
0.55
10.5
8.1
0.6
0.8
%
—
6
38
6
38
1.62
0.55
10.5
8.2
95.1
92.0
%
—
6
38
6
39
1.58
0.54
10.5
8.1
1.6
1.7
%
—
6
39
9
64
1.45
0.53
2.2
3.8
1.8
2.3
mmol/l
—
9
51
16
209
0.71
0.53
2.8
3.5
38.1
373.7
mg/l
—
10
139
69
643
1.39
0.50
30.7
15.3
83.2
85.8
umol/l
0.15
69
643
58
529
1.30
0.48
24.0
13.0
39.0
40.7
%
0.61
37
365
15
193
0.73
0.45
2.5
3.4
—
—
—
0
0
44
392
1.25
0.42
5.5
3.7
—
—
—
0
0
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
16
127
1.32
0.37
3.1
3.6
—
—
—
0
0
6
44
1.39
0.35
2.8
2.0
—
—
—
0
0
6
46
1.33
0.34
9.5
2.8
4.4
3.3
e9/l
—
6
33
31
273
1.21
0.31
3.7
3.9
23.8
44.0
ng/l
1.51
26
198
52
482
1.20
0.30
28.4
14.2
14.0
13.6
%
1.81
52
470
7
56
1.27
0.30
3.7
3.5
473.0
170.0
ng/l
—
7
49
21
242
0.82
0.27
2.2
2.0
100.4
91.2
pmol/l
0.46
12
120
0
11
0.00
0.21
0.0
3.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
104.7
—
0
10
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
4.2
—
0
10
57
542
1.16
0.20
6.6
4.4
3.4
2.0
mu/l
2.28
51
481
55
577
0.87
0.20
3.4
4.3
1.3
1.3
mmol/l
0.08
48
523
18
200
0.87
0.14
3.0
2.5
0.8
0.8
ug/l
0.01
13
125
57
590
0.90
0.13
4.4
4.7
5.8
6.2
mmol/l
1.79
52
526
21
192
1.12
0.12
3.5
3.8
—
—
—
0
0
5
44
1.14
0.10
4.8
3.3
—
—
—
0
0
14
154
0.89
0.09
4.8
2.8
—
—
—
0
0
6
58
1.04
0.08
1.3
1.1
—
—
—
0
0
26
270
0.95
0.04
7.4
4.4
0.0
0.0
estimate
—
5
51
26
270
0.95
0.04
4.8
3.4
0.0
0.0
estimate
—
5
50
27
278
0.96
0.02
4.3
3.4
0.0
0.0
estimate
—
5
51
21
204
1.04
0.00
4.4
3.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
6
60
1.00
0.00
1.2
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_LIP_ORAL_PHARYNX_NAS_EXALLC – Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx, excluding all cancers (controls excluding all cancers)

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).