No definition available.
Malignant neoplasm of hypopharynx, excluding all cancers (controls excluding all cancers)
C3_HYPOPHARYNX_EXALLC
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
239 |
4. Check minimum number of eventsNone |
239 |
5. Include endpoints |
239 |
6. Filter based on genotype QC (FinnGen only) |
239 |
Control definitions (FinnGen only)
- Control exclude
- C3_CANCER, C3_CANCER_WIDE_EXALLC
Extra metadata
- First used in FinnGen datafreeze
- DF12
Similar endpoints
↥List of similar endpoints to
Malignant neoplasm of hypopharynx, excluding all cancers (controls excluding all cancers)
based on the number of shared cases.
Similar with more cases:
- Malignant neoplasm of head and neck, excluding all cancers (controls excluding all cancers)
- Malignant neoplasm, excluding all cancers (controls excluding all cancers)
- Malignant neoplasm, wide definition for exclusion
- Malignant neoplasm, wide definition for exclusion, excluding all cancers (controls excluding all cancers)
- Neoplasms
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded (different definition than used in FinnGen).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 239 | 39 | 200 |
| Unadjusted period prevalence (%) | 0.08 | 0.01 | 0.09 |
| Median age at first event (years) | 67.96 | 65.14 | 68.51 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 126
- Matched controls
- 1260
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
130
Kela drug reimbursment
Malignant tumour
+∞
110.1
89
*
UJC01
NOMESCO Finland
Scopy of lower throat
491.7
95.0
84
5
JDB10
NOMESCO Finland
Percutaneous gastrostomy
458.6
92.1
82
5
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
382.1
90.9
82
6
8070/3-C13.9
ICD-O-3
Squamous cell carcinoma, NOS, of hypopharynx, NOS
+∞
79.9
68
*
WF002
NOMESCO Finland
Radical radiotherapy
563.4
66.1
60
*
C13.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of hypopharynx
+∞
65.4
57
*
C13.9
ICD-10 Finland
Malignant neoplasm: Hypopharynx, unspecified
+∞
48.0
43
*
A03FA01
ATC
metoclopramide; systemic, rectal
27.4
47.1
69
53
N02AA05
ATC
oxycodone; systemic
18.0
37.9
65
70
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
36.2
33
*
H02AB02
ATC
dexamethasone; systemic
103.3
35.1
37
5
R4190
NOMESCO Finland
Nutritional therapy
119.6
33.7
35
*
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
63.1
29.1
33
7
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
339.8
27.9
27
*
GBB00
NOMESCO Finland
Tracheostomy
57.8
27.0
31
7
YA1VG
NOMESCO Finland
MRI examination of head and neck with high intesity magnet for dose design of radiotherapy
+∞
25.9
24
*
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
+∞
25.9
24
*
UJC02
NOMESCO Finland
Rigid oesophagoscopy
113.5
25.8
27
*
D10.7
ICD-10 Finland
Benign neoplasm: Hypopharynx
+∞
24.8
23
*
C13.1
ICD-10 Finland
Malignant neoplasm: Aryepiglottic fold, hypopharyngeal aspect
+∞
24.8
23
*
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
67.9
24.2
27
5
C12
ICD-10 Finland
Malignant neoplasm of piriform sinus
+∞
23.7
22
*
XX3DW
NOMESCO Finland
Time consuming IT work
20.7
22.7
34
22
C77.0
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Lymph nodes of head, face and neck
+∞
22.6
21
*
GDA98
NOMESCO Finland
Other bronchoscopic incision, excision of lesion or repair of lung
263.7
22.3
22
*
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
12.0
21.7
42
50
C13.2
ICD-10 Finland
Malignant neoplasm: Posterior wall of hypopharynx
+∞
21.5
20
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
29.5
21.1
28
12
A04AA01
ATC
ondansetron; systemic, rectal
69.5
20.7
23
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
6.8
20.5
64
165
A04AA02
ATC
granisetron; systemic, transdermal
+∞
20.3
19
*
ZX090
NOMESCO Finland
Other technic of radiotherapy
+∞
20.3
19
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
20.3
19
*
UDQ12
NOMESCO Finland
Flexible laryngoscopy
16.7
19.8
32
25
YA1CD
NOMESCO Finland
Very extensive CT examination of head and neck for dose design of radiotherapy
+∞
19.2
18
*
WX408
NOMESCO Finland
General anesthesy, balanced
6.2
18.4
62
171
C13.0
ICD-10 Finland
Malignant neoplasm: Postcricoid region
+∞
18.1
17
*
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
+∞
18.1
17
*
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
110.8
18.1
19
*
D38.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Larynx
110.8
18.1
19
*
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
49.7
17.9
21
5
Z51.5
ICD-10 Finland
Palliative care
23.6
17.7
25
13
WZC30
NOMESCO Finland
Teaching
9.6
17.6
38
54
ZX095
NOMESCO Finland
Combined chemoradiotherapy
+∞
17.1
16
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
9.1
17.0
38
57
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
13.6
16.6
29
27
EBA15
NOMESCO Finland
Extraction of large number of teeth
16.9
16.4
26
19
D37.08
ICD-10 Finland
Tumor of uncertain or unknown nature in other part of lip, oral cavity and pharynx
+∞
16.0
15
*
UDH02
NOMESCO Finland
Rhinopharyngoscopy
11.2
15.6
30
34
UDQ22
NOMESCO Finland
Microlaryngoscopy
52.0
15.5
18
*
GD1AD
NOMESCO Finland
Thorax CT examination
15.3
14.1
23
18
8070/3-C12.9
ICD-O-3
Squamous cell carcinoma, NOS, of pyriform sinus
+∞
13.8
13
*
R22.1
ICD-10 Finland
Localized swelling, mass and lump, neck
17.7
13.7
21
14
WX402
NOMESCO Finland
General anaesthesia
6.8
13.4
36
70
EP1DG
NOMESCO Finland
Very extensive examination of soft tissue of neck with high intesity magnet
77.9
12.9
14
*
8070/3-C13.2
ICD-O-3
Squamous cell carcinoma, NOS, of posterior wall of hypopharynx
+∞
12.7
12
*
WF004
NOMESCO Finland
Palliative radiotherapy
+∞
12.7
12
*
DQE00
NOMESCO Finland
Implantation of prosthetic replacement for larynx
+∞
12.7
12
*
JN4KR
NOMESCO Finland
Whole body very extensive metabolic PET with CT
+∞
12.7
12
*
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
4.1
12.6
70
294
R13
ICD-10 Finland
Dysphagia
8.5
12.5
28
41
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
7.3
12.4
31
54
WX002
NOMESCO Finland
Sedation and analgesia
4.7
11.8
46
137
PJD71
NOMESCO Finland
Extended sparing excision of cervical lymph nodes
+∞
11.6
11
*
ZZQ00
NOMESCO Finland
Free microvascular graft of skin
+∞
11.6
11
*
JN4JR
NOMESCO Finland
Whole body extensive metabolic PET with CT
+∞
11.6
11
*
ZX070
NOMESCO Finland
Intensity modified radiotherapy
+∞
11.6
11
*
ENA10
NOMESCO Finland
Biopsy of pharynx
+∞
11.6
11
*
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
+∞
11.6
11
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
11.6
11
*
PJD81
NOMESCO Finland
Excision of lymph nodes from upper part of neck
+∞
11.6
11
*
UJC12
NOMESCO Finland
Flexible oesophagoscopy
131.4
11.6
12
*
ZXE00
NOMESCO Finland
One hour or less
3.8
11.6
69
302
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
11.7
11.5
21
21
UGC12
NOMESCO Finland
Flexible bronchoscopy
7.5
11.2
27
44
PJ3AT
NOMESCO Finland
Cytology of lymphnode with ultrasound guidance
119.5
10.6
11
*
PJD51
NOMESCO Finland
Block dissection of cervical lymph nodes
+∞
10.6
10
*
TGB20
NOMESCO Finland
Tracheostomy tube replacement
+∞
10.6
10
*
A04AD12
ATC
aprepitant; systemic
+∞
10.6
10
*
TJD20
NOMESCO Finland
Change of gastrostomy tube
35.9
10.5
13
*
A06AD11
ATC
lactulose; oral
4.7
10.5
39
109
WW500
NOMESCO Finland
Blood transfusion
18.7
10.2
15
9
DQA10
NOMESCO Finland
Biopsy of larynx
59.7
9.8
11
*
ZXB10
NOMESCO Finland
Medial
59.7
9.8
11
*
R07.0
ICD-10 Finland
Pain in throat
9.9
9.7
19
22
UDQ02
NOMESCO Finland
Direct laryngoscopy
32.8
9.6
12
*
JCA55
NOMESCO Finland
Endoscopic dilatation of oesophagus
32.8
9.6
12
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
107.7
9.5
10
*
D14.1
ICD-10 Finland
Benign neoplasm: Larynx
107.7
9.5
10
*
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
+∞
9.5
9
*
A07AA02
ATC
nystatin; oral
9.1
9.3
19
24
JN4BD
NOMESCO Finland
Extensive body CT
9.1
9.3
19
24
ZZA00
NOMESCO Finland
Split skin graft
14.0
9.1
15
12
Z2446
NOMESCO Finland
Social worker
7.5
8.6
20
31
EN1AD
NOMESCO Finland
CT examination of mouth and soft tissues of neck
96.1
8.5
9
*
A04AA55
ATC
palonosetron, combinations; systemic
+∞
8.4
8
*
8070/3-C13.1
ICD-O-3
Squamous cell carcinoma, NOS, of hypopharyngeal aspect of aryepiglottic fold
+∞
8.4
8
*
ENB30
NOMESCO Finland
Laryngopharyngectomy
+∞
8.4
8
*
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
9.5
8.1
16
19
N06AX11
ATC
mirtazapine; oral
3.3
8.0
49
204
EBA10
NOMESCO Finland
Surgical removal of tooth
5.0
8.0
26
62
ZXD10
NOMESCO Finland
Scheduled procedure
3.0
7.8
61
299
N05CF01
ATC
zopiclone; oral
3.0
7.7
55
255
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.9
7.7
34
110
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.1
7.4
51
228
RD210
NOMESCO Finland
NA
17.0
7.4
11
7
JDB00
NOMESCO Finland
Gastrostomy
+∞
7.4
7
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
7.4
7
*
DQB30
NOMESCO Finland
Laryngectomy
+∞
7.4
7
*
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
+∞
7.4
7
*
GBB13
NOMESCO Finland
Revision of tracheostomy
+∞
7.4
7
*
C32.1
ICD-10 Finland
Malignant neoplasm: Supraglottis
+∞
7.4
7
*
JCW98
NOMESCO Finland
Other transluminal endoscopic procedure on oesophagus
+∞
7.4
7
*
R4110
NOMESCO Finland
Physiotherapy
3.1
7.1
45
191
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
5.3
7.0
21
46
A02BC05
ATC
esomeprazole; systemic
2.8
6.9
62
325
ZXE10
NOMESCO Finland
More than one and less than three hours
2.8
6.9
55
270
QA1S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in head
42.4
6.8
8
*
ZXE50
NOMESCO Finland
More than nine and less than 12 hours
24.0
6.8
9
*
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
24.0
6.8
9
*
SAA03
NOMESCO Finland
Extended examination of mouth
2.9
6.7
50
234
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
8.9
6.5
13
16
K22.2
ICD-10 Finland
Oesophageal obstruction
19.2
6.4
9
5
C32.9
ICD-10 Finland
Malignant neoplasm: Larynx, unspecified
+∞
6.3
6
*
D10.9
ICD-10 Finland
Benign neoplasm: Pharynx, unspecified
+∞
6.3
6
*
Z43.1
ICD-10 Finland
Attention to gastrostomy
+∞
6.3
6
*
YX9BD
NOMESCO Finland
Other extensive CT eamination for dose design of radiotherapy
+∞
6.3
6
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
6.3
6
*
ENB00
NOMESCO Finland
Excision or exploration of lesion of pharynx
+∞
6.3
6
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.6
6.2
66
375
ZXD05
NOMESCO Finland
Urgent procedure
2.7
6.1
53
268
Mortality – FinRegistry
↥This endpoint is excluded (different definition than used in FinnGen).
Relationships between endpoints
↥Index endpoint: C3_HYPOPHARYNX_EXALLC – Malignant neoplasm of hypopharynx, excluding all cancers (controls excluding all cancers)
GWS hits: 1
This endpoint is excluded (different definition than used in FinnGen).