Benign neoplasm: Epididymis

CD2_BENIGN_EPIDIDYMIS

testicular carcinoma: A primary or metastatic malignant neoplasm that affects the testis. Representative examples include seminoma, embryonal carcinoma, sarcoma, leukemia, and lymphoma.

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

only males

226837

2. Check conditions

None

226837

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D29.3&
  • Hospital discharge: ICD-9 2223
  • Cause of death: ICD-10 D29.3&
  • Cause of death: ICD-9 2223

2 out of 7 registries used, show all original rules.

113

4. Check minimum number of events

None

113

5. Include endpoints

None

113

6. Filter based on genotype QC (FinnGen only)

113

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D29
Name in latin
Neoplasma benignum epididymidis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 908 - 908
Only index persons 837 - 837
Unadjusted period prevalence (%)
Whole population 0.03 - 0.03
Only index persons 0.03 - 0.03
Median age at first event (years)
Whole population - - 51.60
Only index persons - - 50.67

-FinnGen-

Key figures

All Female Male
Number of individuals 113 - 113
Unadjusted period prevalence (%) 0.05 - 0.05
Median age at first event (years) 53.40 - 53.40

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
102
Matched controls
1020
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D29.3
ICD-10 Finland
Benign neoplasm: Epididymis
+∞
112.2
86
*
KFD16
NOMESCO Finland
Partial excision of epididymis
+∞
25.0
23
*
2223A
ICD-9 Finland
Benign neoplasm of male genital organs, Epididymis
+∞
17.2
16
*
KF8AE
NOMESCO Finland
Ultrasound examination of scrotum
12.4
9.2
16
15
N43.4
ICD-10 Finland
Spermatocele
10.9
8.7
16
17
D40.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Testis
48.9
7.8
9
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
48
292
2.12
3.62
1.8
2.0
—
—
—
0
0
45
287
1.94
2.85
3.5
2.8
38.5
261.7
e6/l
0.50
34
222
90
726
2.18
2.84
3.3
3.7
1.8
2.0
mu/l
0.75
83
654
5
6
8.64
2.77
2.2
2.0
—
—
—
0
0
56
390
1.86
2.68
5.9
8.1
1.2
1.2
inr
0.05
16
108
31
179
2.01
2.57
3.6
2.7
624.4
609.8
mosm/kgh2o
0.13
25
153
31
182
1.97
2.45
2.3
3.2
—
—
—
0
0
73
573
1.77
2.19
4.1
3.9
—
—
—
0
0
102
895
2.43
2.15
13.9
15.2
28.4
26.7
mg/l
0.18
84
719
105
949
2.50
2.05
17.1
18.3
90.4
86.9
umol/l
0.72
105
949
8
27
3.11
1.98
3.4
5.3
—
—
—
0
0
45
316
1.70
1.95
4.1
3.2
36.6
108.5
e6/l
0.42
33
237
8
28
2.99
1.90
1.1
1.1
—
—
—
0
0
38
260
1.70
1.79
3.7
2.8
0.5
0.6
e6/l
0.11
27
196
35
235
1.71
1.76
3.3
4.1
7.4
7.4
ph
—
10
42
42
301
1.63
1.64
1.8
2.0
77.3
89.5
pmol/l
1.10
23
168
102
923
2.08
1.51
14.0
14.7
—
—
—
0
0
91
796
1.74
1.50
14.5
16.3
42.0
41.4
%
0.31
61
593
18
104
1.87
1.47
1.3
1.4
—
—
—
0
0
16
91
1.88
1.37
1.5
1.4
—
—
—
0
0
16
94
1.82
1.25
1.3
1.3
—
—
—
0
0
8
40
2.07
1.14
3.4
4.7
—
—
—
0
0
7
32
2.26
1.10
3.6
2.4
—
—
—
0
0
33
244
1.50
1.08
4.0
2.7
—
—
—
0
0
100
922
1.74
1.05
18.2
17.9
4.0
4.0
mmol/l
0.85
100
905
7
37
1.95
0.96
5.0
2.7
—
—
—
0
0
99
918
1.63
0.91
18.3
17.8
139.6
139.6
mmol/l
0.10
99
900
37
289
1.42
0.91
4.5
2.9
62.7
55.6
u/l
0.79
32
274
46
376
1.38
0.86
4.0
3.9
18.1
51.5
ng/l
2.60
37
272
12
75
1.67
0.78
2.5
4.0
—
—
—
0
0
9
54
1.72
0.77
6.0
6.7
26.3
24.2
mmol/l
—
9
54
21
154
1.45
0.71
1.8
1.9
31.2
29.8
s
0.31
21
149
29
227
1.37
0.69
3.4
3.1
—
—
—
0
0
24
182
1.40
0.69
4.0
5.5
—
—
—
0
0
92
856
1.40
0.66
5.0
4.6
6.0
6.2
mmol/l
1.50
85
788
6
104
0.55
0.65
1.7
1.3
—
292.7
—
0
22
32
257
1.34
0.65
4.1
4.2
—
—
—
0
0
47
402
1.29
0.61
7.5
6.7
27.3
25.6
%
0.47
42
384
73
661
1.29
0.61
5.2
4.5
1.9
2.4
ug/l
0.48
63
593
48
414
1.28
0.58
3.2
3.5
0.0
0.0
estimate
—
7
62
47
407
1.27
0.55
4.8
4.8
0.0
0.0
estimate
—
8
68
6
100
0.58
0.54
1.2
1.4
—
—
—
0
0
70
636
1.26
0.54
3.9
4.1
—
—
—
0
0
6
40
1.53
0.52
1.3
1.2
—
—
—
0
0
44
382
1.25
0.49
10.7
10.4
0.0
0.0
e9/l
0.52
36
315
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
2.8
—
3.0
—
0
16
8
61
1.33
0.40
6.4
3.6
—
—
—
0
0
13
98
1.37
0.39
2.5
4.5
—
—
—
0
0
11
146
0.73
0.39
1.6
2.0
—
—
—
0
0
25
209
1.25
0.38
7.6
6.6
—
—
—
0
0
25
209
1.25
0.38
1.5
1.3
—
—
—
0
0
79
835
0.82
0.37
6.9
6.3
40.3
41.5
mmol/mol
0.62
74
788
91
869
1.24
0.35
4.1
4.1
1.3
1.4
mmol/l
0.38
85
798
6
45
1.35
0.34
1.7
1.9
—
—
—
0
0
45
405
1.18
0.34
3.4
3.5
0.0
0.0
estimate
—
7
67
10
74
1.39
0.33
1.2
1.4
—
—
—
0
0
47
426
1.18
0.32
5.7
6.5
0.7
0.6
e9/l
0.32
41
372
47
428
1.17
0.30
5.8
6.6
0.0
0.0
e9/l
0.02
42
376
16
193
0.80
0.29
2.8
3.6
—
—
—
0
0
5
73
0.67
0.27
1.4
3.8
—
—
—
0
0
13
159
0.79
0.27
1.2
1.3
0.9
1.2
u/ml
—
6
52
13
105
1.27
0.26
7.2
7.6
96.8
95.7
%
0.67
13
100
14
115
1.25
0.25
7.5
7.4
5.0
5.0
kpa
0.04
14
107
14
115
1.25
0.25
7.4
7.4
13.3
11.5
kpa
0.53
14
109
31
277
1.16
0.25
4.0
5.2
—
—
—
0
0
12
97
1.27
0.24
2.3
4.4
3.2
1.6
mmol/l
—
7
74
5
38
1.33
0.23
1.4
1.8
—
—
—
0
0
0
10
0.00
0.21
0.0
2.3
—
—
—
0
0
0
12
0.00
0.21
0.0
13.0
—
1090.3
—
0
12
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
9
110
0.80
0.21
1.4
1.6
—
—
—
0
0
6
48
1.26
0.20
11.3
9.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
7
62
1.14
0.17
1.7
2.4
—
—
—
0
0
5
70
0.70
0.17
1.2
1.5
—
—
—
0
0
30
275
1.12
0.16
2.8
2.5
—
—
—
0
0
9
82
1.11
0.15
2.3
2.9
4.3
4.7
kpa
—
9
77
9
82
1.11
0.15
1.4
1.4
—
—
—
0
0
20
220
0.89
0.13
3.9
3.8
0.0
0.0
estimate
—
7
58
12
104
1.17
0.13
1.5
1.5
—
—
—
0
0
41
388
1.09
0.12
3.4
2.8
0.7
0.7
ug/l
0.22
28
247
31
290
1.10
0.12
3.6
3.4
8.8
8.6
mmol/l
0.09
25
246
29
272
1.09
0.10
4.0
3.6
30.2
85.1
mg/l
1.85
20
193
15
165
0.90
0.09
5.5
3.8
0.8
0.8
mmol/l
0.16
15
153
7
67
1.05
0.08
6.7
7.8
24.4
24.1
mmol/l
—
7
62
11
98
1.14
0.08
2.5
4.3
6.1
5.7
kpa
0.92
11
93
6
73
0.81
0.08
2.8
4.7
—
—
—
0
0
28
295
0.93
0.07
5.9
4.3
4.9
12.8
mg/mmol
1.33
18
205
10
89
1.14
0.07
8.7
7.7
—
—
—
0
0
9
104
0.85
0.06
1.3
1.5
—
—
—
0
0
10
108
0.92
0.03
1.3
1.5
—
—
—
0
0
13
138
0.93
0.02
2.2
1.8
—
—
—
0
0
34
342
0.99
0.00
3.5
2.9
—
—
—
0
0
29
291
1.00
0.00
8.2
6.2
—
—
—
0
0
0
8
0.00
0.00
0.0
3.3
—
34.1
—
0
8
0
5
0.00
0.00
0.0
1.0
—
49.4
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
9.0
—
0.6
—
0
8
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
138.2
—
0
5
0
8
0.00
0.00
0.0
1.9
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
2.7
—
—
—
0
0
5
52
0.96
0.00
15.0
9.6
24.2
24.3
mmol/l
—
5
47
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
7
75
0.93
0.00
1.1
1.5
—
—
—
0
0
5
49
1.02
0.00
5.0
2.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
9
94
0.95
0.00
1.7
1.9
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
5
58
0.86
0.00
2.8
2.8
0.9
1.6
%
—
5
58

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_EPIDIDYMIS and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_EPIDIDYMIS 0.951 [0.75, 1.2] 0.673
Birth year 0.985 [0.98, 0.99] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 98 out of 637 males with CD2_BENIGN_EPIDIDYMIS died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_EPIDIDYMIS.

N-year risk Females Males
1 No data 0.15%
5 No data 1.044%
10 No data 2.681%
15 No data 5.038%
20 No data 8.452%

Relationships between endpoints

Index endpoint: CD2_BENIGN_EPIDIDYMIS – Benign neoplasm: Epididymis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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