Benign neoplasm: Vertebral column

CD2_BENIGN_VERTEB_COLUMN

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D16.6& Hospital discharge: ICD-9 — 2132 Hospital discharge: ICD-8 — 21301 Cause of death: ICD-10 — D16.6& Cause of death: ICD-9 — 2132 Cause of death: ICD-8 — 21301 2 out of 7 registries used, show all original rules.	88
4. Check minimum number of events None	88
5. Include endpoints None	88
6. Filter based on genotype QC (FinnGen only)	88

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: D16
Name in latin: Neoplasma benignum columnae vertebralis

NAME	CD2_BENIGN_VERTEB_COLUMN
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D166
HD_ICD_9	2132
HD_ICD_8	21301
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D166
COD_ICD_9	2132
COD_ICD_8	21301
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Benign neoplasm: Vertebral column based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Benign neoplasm: Vertebral column

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	88	46	42
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	52.69	49.76	55.89

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
75: Matched controls
748

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

D16.6

ICD-10 Finland

Benign neoplasm: Vertebral column

+∞

71.8

21301

ICD-8 Finland

Benign neoplasm of bone and cartilage, Columnae vertebralis (sacro et coccyge exclusis)

+∞

14.0

NA2AD

NOMESCO Finland

Thoracic spine CT examination

76.0

6.5

D48.0

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Bone and articular cartilage

29.4

6.4

2132A

ICD-9 Finland

Benign neoplasm of bone and articular cartilage, Vertebral column, excluding sacrum and coccyx

+∞

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(40761535) Cells panel - Urine sediment

2.97

3.15

5.3

3.5

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

2.68

2.52

2.6

3.7

60.0

66.6

ml/min/173m2

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

2.36

2.31

6.6

8.6

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

3.22

2.22

1.4

1.3

21.1

26.0

iu/l

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

326

1.86

2.14

5.8

9.2

1.2

mmol/l

0.90

275

(3021601) Nitrite [Presence] in Urine by Test strip

345

1.86

2.13

6.6

5.2

0.0

estimate

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

169

1.96

2.11

6.1

3.4

—

(3048689) Calprotectin [Mass/mass] in Stool

2.21

2.01

1.2

2.4

177.0

100.4

ug/g

—

(3044889) 12 lead EKG panel

490

1.90

1.98

4.0

3.7

—

(40760888) Immunoglobulin light chains.free panel - Serum

4.75

1.97

2.6

2.7

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.13

1.85

1.5

1.6

—

(40768797) Stomach Pathology biopsy report

104

2.05

1.85

1.3

1.2

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.10

1.80

1.5

1.6

—

(3035350) Ketones [Presence] in Urine by Test strip

350

1.74

1.75

5.6

3.7

0.0

estimate

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

4.01

1.74

1.4

1.3

—

(40768804) Tissue Pathology biopsy report

295

1.73

1.71

2.6

2.0

—

(3009261) Glucose [Presence] in Urine by Test strip

354

1.70

1.65

5.5

3.7

0.0

estimate

—

(3020891) Body temperature

2.83

1.61

5.9

5.0

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

3.25

1.46

1.6

1.4

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

146

1.78

1.45

4.7

2.9

0.8

ug/l

0.06

104

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

2.48

1.33

4.5

4.8

49.5

52.4

—

(3009542) Hematocrit [Volume Fraction] of Blood

639

1.84

1.31

15.9

15.1

41.1

40.1

0.98

479

(3029937) Albumin [Presence] in Urine by Test strip

195

1.64

1.26

7.1

3.6

0.0

estimate

—

(3037467) Urinalysis macro (dipstick) panel - Urine

481

1.60

1.25

4.8

4.1

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

269

1.57

1.21

6.4

3.9

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

1.83

1.16

5.4

9.3

1.1

1.0

mmol/l

0.38

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

192

1.59

1.11

6.1

4.7

22.4

20.6

0.18

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

125

1.66

1.05

2.5

3.1

2.2

1.0

e6/l

0.36

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

2.35

1.05

1.4

1.5

—

(3003327) Ova and parasites identified in Stool by Light microscopy

2.35

1.05

1.4

1.5

—

(3030467) Casts [#/volume] in Urine by Automated count

195

1.55

1.03

2.7

3.3

0.2

0.3

e6/l

0.37

140

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

0.00

0.99

0.0

2.1

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

270

1.49

0.99

2.0

2.1

99.8

95.9

pmol/l

0.23

136

(3000494) Fungus identified in Specimen by Culture

1.70

0.95

2.5

1.7

—

(36304419) Bacteria [Presence] in Urine

190

1.52

0.94

2.6

3.1

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

245

1.48

0.93

3.6

3.3

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.99

0.91

2.0

1.5

—

(3032080) INR in Blood by Coagulation assay

293

1.45

0.90

8.8

6.9

1.3

1.2

inr

—

(4010399)

1.90

0.89

1.8

1.4

—

(3028026) IgM [Mass/volume] in Serum or Plasma

1.90

0.89

2.5

1.3

0.8

1.2

g/l

—

(40758558) Short blood count panel - Blood

175

1.51

0.87

11.1

6.8

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.80

0.0

1.6

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.78

0.78

2.2

1.6

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

2.24

0.77

1.4

—

(40761511) CBC panel - Blood by Automated count

752

1.70

0.70

15.4

13.1

—

(3019060) Gas panel - Arterial blood

1.72

0.70

3.4

16.1

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

121

1.50

0.69

1.6

1.8

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

717

1.59

0.68

5.2

5.1

2.8

2.7

mmol/l

0.06

659

(3001019) Free T4 and TSH panel - Serum or Plasma

1.83

0.67

1.8

1.7

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

698

1.50

0.62

4.3

4.6

1.5

mmol/l

0.02

638

(3021589) Normoblasts [#/volume] in Blood

290

1.34

0.62

10.0

9.8

0.0

e9/l

0.49

229

(3024891) Influenza virus A+B Ag [Presence] in Specimen

0.00

0.61

0.0

1.1

—

(3051387) C reactive protein [Mass/volume] in Capillary blood

0.00

0.61

0.0

3.8

—

28.4

—

(3026008) Bacteria identified in Urine by Culture

206

1.37

0.61

5.3

3.1

—

(3020779) Urea [Moles/volume] in Serum or Plasma

1.56

0.60

7.1

11.8

8.3

9.9

mmol/l

—

(3000991) Gas panel - Venous blood

1.58

0.57

10.4

9.4

—

(3031040) Bacteria [#/volume] in Urine by Automated count

461

1.31

0.56

6.2

4.2

—

5079.5

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

1.62

0.55

5.5

4.9

25.2

24.8

mmol/l

—

(3002256) Pathology report gross observation

1.52

0.55

1.1

1.3

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.58

0.54

5.2

2.9

1.0

1.4

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.47

0.52

1.6

1.5

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

1.53

0.49

1.8

2.1

365.7

402.8

nmol/l

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.53

0.49

1.9

1.7

—

(3007164) IgA [Mass/volume] in Serum or Plasma

139

1.37

0.48

1.7

1.4

2.4

2.7

g/l

0.18

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

214

1.31

0.47

2.3

2.1

208.2

173.6

u/l

0.16

203

(3023368) Bacteria identified in Blood by Culture

186

1.32

0.47

4.3

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

300

1.28

0.47

4.5

2.6

120.9

106.4

ug/l

0.17

269

(4035726)

1.51

0.46

1.6

1.3

—

(40761536) Microorganisms panel - Urine sediment

1.44

0.43

5.8

4.0

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.60

0.43

6.4

26.5

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

161

1.31

0.42

1.3

1.0

0.9

u/ml

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.41

0.0

3.5

—

3.7

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.41

0.0

2.8

—

(3024928) Oxygen saturation in Venous blood

0.00

0.41

0.0

4.0

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.41

0.0

1.2

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.41

0.0

1.2

—

(40766183) Gliadin peptide IgA Ab [Units/volume] in Serum by Immunoassay

0.00

0.41

0.0

1.1

—

4.3

—

(3013115) Eosinophils [#/volume] in Blood

374

1.24

0.39

6.6

6.0

0.2

e9/l

1.07

337

(3018095) Leukocytes [#/volume] in Urine

248

1.25

0.39

3.3

3.9

12.9

60.9

e6/l

1.65

175

(3002032) Base excess in Venous blood by calculation

1.32

0.38

7.9

5.2

2.8

1.7

mmol/l

—

(40760892) CBC W Ordered Manual Differential panel - Blood

164

1.28

0.37

7.6

5.6

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

1.42

0.36

3.2

2.7

0.2

g/l

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.39

0.35

6.8

5.5

27.3

25.2

mmol/l

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

705

1.31

0.35

5.0

4.6

mmol/l

0.14

652

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

0.66

0.35

1.3

2.2

1.2

1.4

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

428

1.21

0.34

10.5

9.9

4.5

4.1

e9/l

0.50

371

(3019198) Lymphocytes [#/volume] in Blood

372

1.19

0.30

6.5

5.9

1.8

1.9

e9/l

0.40

335

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

677

1.25

0.30

4.4

4.2

1.1

1.3

mmol/l

1.70

619

(42870588) Differential panel, method unspecified - Blood

237

1.20

0.28

5.9

5.4

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

325

1.18

0.27

5.4

4.5

—

(3002385) Erythrocyte distribution width [Ratio]

597

1.19

0.26

19.8

16.9

13.6

13.8

0.49

586

(3002582) Erythrocytes [#/volume] in Urine

220

1.19

0.25

2.6

3.4

82.1

24.3

e6/l

0.35

164

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

692

1.22

0.24

4.4

4.7

5.7

6.0

mmol/l

0.79

634

(3000330) Specific gravity of Urine by Test strip

1.33

0.23

4.2

4.3

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

117

1.23

0.22

2.6

3.2

0.8

2.3

e6/l

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

123

0.79

0.22

1.8

1.7

—

(40768795) Lymph node Pathology biopsy report

0.00

0.21

0.0

1.0

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.21

0.0

1.1

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.21

0.0

1.5

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.5

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.7

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.21

0.0

1.1

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.7

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.6

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.21

0.0

1.1

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.21

0.0

1.6

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.21

0.0

1.4

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.6

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.6

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.21

0.0

1.1

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.2

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.3

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.21

0.0

1.2

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.21

0.0

1.2

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.21

0.0

2.4

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

(3019230) Fractional oxyhemoglobin in Venous blood

0.00

0.20

0.0

2.7

—

56.4

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

727

1.21

0.20

16.3

14.2

19.1

21.8

mg/l

0.39

570

(3001604) Monocytes [#/volume] in Blood

362

1.14

0.19

6.6

5.7

0.5

0.6

e9/l

1.71

316

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

666

1.17

0.18

13.0

13.2

84.1

81.6

ml/min/173m2

0.37

542

(3041096) Erythrocytes [Presence] in Urine by Automated

187

1.16

0.18

3.9

3.7

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

1.21

0.17

2.6

2.3

3.3

4.9

ug/l

—

(3042936) Bacteria identified in Isolate by Culture

111

1.20

0.17

2.0

2.5

—

(3022145) Colonoscopy Study observation

1.14

0.16

1.4

1.3

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

161

1.15

0.14

3.3

2.0

2.8

3.1

mg/l

0.33

142

(1761868) Lipid panel - Serum or Plasma

260

0.89

0.13

3.2

3.0

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

470

1.10

0.11

2.8

3.0

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

154

1.13

0.11

3.1

1.7

8.5

1.3

mg/l

0.55

122

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.17

0.10

1.0

—

(3006315) Basophils [#/volume] in Blood

362

1.09

0.10

6.8

5.8

0.0

e9/l

0.07

319

(3044640) Blood type and Crossmatch panel - Blood

215

1.09

0.08

3.8

2.7

—

(3022948) Iron [Moles/volume] in Serum or Plasma

123

0.88

0.08

2.6

2.7

13.3

12.8

umol/l

0.11

112

(3023520) Reticulocytes [#/volume] in Blood

0.79

0.08

3.6

2.5

48.4

73.2

e9/l

—

(36660697) Celiac disease serology panel - Serum

1.12

0.08

1.1

1.2

—

(3000492) Spirometry study

0.85

0.08

1.5

1.3

—

(3012544) pH of Venous blood

1.06

0.07

8.0

5.2

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.03

0.07

1.6

1.3

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

0.86

0.07

3.9

3.2

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

297

1.07

0.06

4.2

4.0

47.5

39.8

ng/l

0.12

201

(3007853) Bacteria identified in Skin by Aerobe culture

1.13

0.06

3.5

1.6

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

120

1.10

0.05

8.8

4.1

0.8

mmol/l

0.02

110

(3003694) ABO and Rh group [Type] in Blood

179

0.94

0.03

1.3

—

(3013512) EKG study

189

0.94

0.03

4.5

4.2

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.03

0.00

1.5

1.6

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

127

1.03

0.00

1.5

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

164

0.97

0.00

3.9

2.7

—

(3012516) Albumin [Mass/volume] in Urine

196

1.03

0.00

3.1

3.5

27.1

69.6

mg/l

1.43

134

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

574

0.98

0.00

8.4

8.0

71.1

77.5

u/l

0.66

530

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.87

0.00

1.8

1.9

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.02

0.00

1.4

1.9

—

(3045788) Cell count panel - Pleural fluid

0.00

0.0

1.4

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.3

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

1.8

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.0

2.3

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3010838) Calcium [Moles/time] in 24 hour Urine

0.00

0.0

1.0

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.3

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.0

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

0.0

1.2

—

35.9

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.0

1.7

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.6

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.02

0.00

1.4

1.6

—

(3024474) Albumin [Mass/volume] in Cerebral spinal fluid

0.00

0.0

1.1

—

278.1

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.3

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.2

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

0.00

0.0

2.0

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

0.0

1.5

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3011648) Oxygen content in Venous blood

0.00

0.0

2.5

—

11.4

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

1.6

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

0.0

2.4

—

(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma

0.00

0.0

9.4

—

0.6

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.7

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.0

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.6

—

(3043453) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum

0.00

0.0

1.2

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.90

0.00

1.7

2.1

—

(21494755) Public health laboratory ask at order entry panel

0.88

0.00

1.3

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.3

—

(3000012) Reticulocyte production index

0.00

0.0

1.0

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.4

—

128.2

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

0.91

0.00

1.5

1.6

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

0.94

0.00

1.4

—

(21491868) Cryoglobulin [Mass/volume] in Serum

0.00

0.0

1.0

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.6

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.0

1.9

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.0

1.3

—

(3029634) Reagin Ab [Titer] in Serum by VDRL

0.00

0.0

2.4

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

1.2

—

0.9

—

(36306090) Helicobacter pylori [Presence] in Tissue by Organism specific culture

0.00

0.0

1.0

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.6

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.0

1.1

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.3

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.1

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

0.0

1.3

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.9

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

2.4

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

0.0

1.6

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

7.3

—

728.7

—

(3009550) Parvovirus B19 IgG Ab [Titer] in Serum

0.00

0.0

1.1

—

(4281824)

0.00

0.0

1.0

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.3

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

2.2

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

0.0

1.3

—

(3041423) Sjogrens syndrome-A extractable nuclear 60kD Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.0

1.6

—

(3014271) Vancomycin [Susceptibility]

0.00

0.0

2.0

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

9.0

—

1214.2

—

(3040151) Glucose [Moles/volume] in Capillary blood

0.00

0.0

2.7

—

6.9

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.0

1.6

—

(4027681)

0.00

0.0

1.4

—

(3009876) Amylase isoenzyme 3 panel - Serum or Plasma

0.00

0.0

1.2

—

(3020682) Albumin/Creatinine [Ratio] in Urine

210

1.00

0.00

3.6

4.2

5.8

10.5

mg/mmol

0.62

138

(42529215) Follitropin [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

1.7

—

38.0

—

(3022217) INR in Platelet poor plasma by Coagulation assay

0.98

0.00

17.6

17.0

—

1.2

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.0

1.3

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.3

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

0.0

4.1

—

118.6

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.0

1.7

—

(3044927) Protein electrophoresis panel - Urine

0.00

0.0

1.2

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.6

—

(3005715) Vancomycin [Mass/volume] in Serum or Plasma

0.00

0.0

11.7

—

10.3

—

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: CD2_BENIGN_VERTEB_COLUMN – Benign neoplasm: Vertebral column

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Benign neoplasm: Vertebral column

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Benign neoplasm: Vertebral column (CD2_BENIGN_VERTEB_COLUMN)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Relationships between endpoints