This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Non-neuropathic heredofamilial amyloidosis
E4_AMYL_NONNEURO
No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
42 |
4. Check minimum number of eventsNone |
42 |
5. Include endpointsNone |
42 |
6. Filter based on genotype QC (FinnGen only) |
42 |
Control definitions (FinnGen only)
- Control exclude
- E4_METABOLIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E85
- Name in latin
- Amyloidosis (heredo)familialis non neuropathica
Similar endpoints
↥List of similar endpoints to
Non-neuropathic heredofamilial amyloidosis
based on the number of shared cases.
Similar with more cases:
- Amyloidosis
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 340 | 178 | 158 |
| Only index persons | 227 | 120 | 107 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.00 | 0.01 | 0.00 |
| Only index persons | 0.00 | 0.00 | 0.00 |
| Median age at first event (years) | |||
| Whole population | 63.80 | 64.07 | 63.99 |
| Only index persons | 62.36 | 60.71 | 64.20 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 42 | 24 | 18 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 56.82 | 50.91 | 64.71 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
No data available
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3004588) Protein electrophoresis panel - Serum or Plasma
12
17
9.48
8.48
4.3
1.3
—
—
—
0
0
(3037756) Immunofixation for Serum or Plasma
9
6
18.53
6.22
2.3
1.3
—
—
—
0
0
(40760888) Immunoglobulin light chains.free panel - Serum
8
5
19.22
5.65
9.0
1.2
—
—
—
0
0
(3013005) Retinol [Moles/volume] in Serum or Plasma
5
0
+∞
5.30
2.8
0.0
umol/l
2.3
—
—
5
0
(40763571) Iron/Transferrin [Ratio] in Serum or Plasma
14
44
4.27
4.23
4.3
1.6
%
18.0
20.3
0.35
14
37
(3022948) Iron [Moles/volume] in Serum or Plasma
15
53
3.85
3.84
4.6
1.6
umol/l
10.4
12.6
0.75
15
46
(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma
25
128
3.35
3.57
4.3
1.8
nmol/l
80.0
75.5
0.35
25
107
(42870588) Differential panel, method unspecified - Blood
22
110
3.10
3.18
10.0
5.0
—
—
—
0
0
(3000494) Fungus identified in Specimen by Culture
11
36
3.78
3.07
2.4
1.7
—
—
—
0
0
(3000620) Complement C3 [Mass/volume] in Serum or Plasma
5
5
11.09
3.06
1.4
1.6
g/l
1.1
1.0
—
5
5
(3017766) Complement C4 [Mass/volume] in Serum or Plasma
5
5
11.09
3.06
1.4
1.6
g/l
0.2
0.2
—
5
5
(3042936) Bacteria identified in Isolate by Culture
14
57
3.18
2.80
2.6
2.2
—
—
—
0
0
(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
6
10
6.78
2.80
2.7
1.0
—
—
—
0
0
(3023368) Bacteria identified in Blood by Culture
17
78
2.98
2.79
7.9
4.8
—
—
—
0
0
(3005719) IgG [Mass/volume] in Serum or Plasma
8
22
4.24
2.51
5.3
1.5
g/l
7.0
10.3
—
8
17
(3012544) pH of Venous blood
9
29
3.66
2.40
4.1
2.2
—
—
—
0
0
(3006504) Eosinophils/100 leukocytes in Blood
25
155
2.51
2.16
13.1
4.8
%
2.5
2.5
0.04
25
146
(3019069) Monocytes/100 leukocytes in Blood
25
156
2.49
2.12
13.2
5.0
%
8.2
8.7
0.37
25
147
(40758558) Short blood count panel - Blood
16
81
2.58
2.10
8.4
7.3
—
—
—
0
0
(3002030) Lymphocytes/100 leukocytes in Blood
25
159
2.41
1.99
13.5
4.9
%
29.0
27.8
0.19
25
150
(3022096) Basophils/100 leukocytes in Blood
24
154
2.30
1.83
13.7
4.6
%
0.6
0.7
0.52
24
143
(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection
5
13
4.21
1.77
2.0
1.5
—
—
—
0
0
(3018010) Neutrophils/100 leukocytes in Blood
24
157
2.23
1.71
12.2
4.7
%
58.0
56.6
0.21
24
149
(3044640) Blood type and Crossmatch panel - Blood
18
105
2.25
1.68
3.2
2.0
—
—
—
0
0
(3022313) Gas panel - Capillary blood
5
14
3.90
1.66
6.0
2.9
—
—
—
0
0
(3016293) Bicarbonate [Moles/volume] in Serum or Plasma
5
14
3.90
1.66
1.8
3.9
mmol/l
27.3
24.1
—
5
14
(3007853) Bacteria identified in Skin by Aerobe culture
9
37
2.81
1.60
1.7
1.9
—
—
—
0
0
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
20
129
2.05
1.41
6.3
2.9
—
—
—
0
0
(3019060) Gas panel - Arterial blood
5
18
3.01
1.32
3.8
3.3
—
—
—
0
0
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
8
37
2.43
1.30
1.3
1.6
—
—
—
0
0
(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection
0
33
0.00
1.22
0.0
2.1
—
—
—
0
0
(3020564) Creatinine [Moles/volume] in Serum or Plasma
31
361
0.46
1.21
40.1
16.0
umol/l
96.3
74.0
1.41
31
361
(3032080) INR in Blood by Coagulation assay
19
128
1.88
1.13
7.5
9.3
inr
1.0
1.2
—
5
41
(3015377) Calcium [Moles/volume] in Serum or Plasma
18
120
1.88
1.10
3.5
3.2
mmol/l
2.3
2.4
1.06
18
100
(3012095) Magnesium [Moles/volume] in Serum or Plasma
10
54
2.12
1.07
7.9
3.9
mmol/l
0.8
0.8
—
10
49
(3003694) ABO and Rh group [Type] in Blood
5
100
0.43
1.07
1.4
1.4
—
—
—
0
0
(3014111) Lactate [Moles/volume] in Serum or Plasma
5
22
2.44
1.06
6.4
3.4
mmol/l
1.0
1.4
—
5
22
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
9
51
1.97
1.03
1.6
2.1
—
—
—
0
0
(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection
0
32
0.00
1.00
0.0
1.9
—
—
—
0
0
(40761511) CBC panel - Blood by Automated count
32
364
0.49
0.98
35.2
13.0
—
—
—
0
0
(3037467) Urinalysis macro (dipstick) panel - Urine
28
220
1.82
0.97
5.8
4.3
—
—
—
0
0
(3011397) Hemoglobin [Presence] in Urine by Test strip
12
75
1.84
0.86
5.1
3.3
—
—
—
0
0
(1761868) Lipid panel - Serum or Plasma
9
137
0.56
0.78
2.2
2.9
—
—
—
0
0
(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma
9
57
1.73
0.78
7.0
3.0
ng/l
57.4
79.7
—
9
44
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
7
39
1.95
0.77
1.3
1.6
—
—
—
0
0
(3019900) Cholesterol [Moles/volume] in Serum or Plasma
30
342
0.57
0.76
6.3
4.3
mmol/l
4.4
4.6
0.76
30
316
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
5
25
2.13
0.75
2.8
1.6
—
—
—
0
0
(3015736) pH of Urine
9
130
0.61
0.65
6.3
3.2
—
—
—
0
0
(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma
15
108
1.60
0.65
3.3
2.0
u/l
93.4
162.0
1.13
15
100
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
11
73
1.69
0.64
3.2
1.9
—
—
—
0
0
(3013139) Helicobacter pylori Ag [Presence] in Stool
0
22
0.00
0.61
0.0
1.5
—
—
—
0
0
(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal
0
23
0.00
0.60
0.0
1.0
—
—
—
0
0
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
16
203
0.66
0.57
2.8
3.1
—
—
—
0
0
(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma
8
118
0.60
0.56
2.5
5.0
ug/l
1.0
2.0
—
8
101
(3002582) Erythrocytes [#/volume] in Urine
15
113
1.51
0.52
5.7
2.8
e6/l
18.1
645.9
0.55
15
85
(3020682) Albumin/Creatinine [Ratio] in Urine
14
104
1.52
0.52
4.1
3.6
mg/mmol
36.2
6.1
—
7
60
(3018095) Leukocytes [#/volume] in Urine
16
123
1.49
0.51
7.9
3.3
e6/l
12.6
94.1
0.76
16
89
(3012516) Albumin [Mass/volume] in Urine
13
96
1.51
0.49
5.4
2.9
mg/l
287.0
35.6
—
7
60
(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma
15
115
1.47
0.48
4.1
3.3
u/l
29.3
26.7
0.17
15
109
(36304419) Bacteria [Presence] in Urine
13
97
1.49
0.47
4.8
2.8
—
—
—
0
0
(3019225) pH of Specimen
5
31
1.69
0.45
7.0
3.5
—
—
—
0
0
(3020460) C reactive protein [Mass/volume] in Serum or Plasma
32
349
0.65
0.44
44.6
13.8
mg/l
34.7
21.0
0.98
25
270
(40761535) Cells panel - Urine sediment
5
32
1.64
0.44
7.6
2.8
—
—
—
0
0
(3022621) pH of Urine by Test strip
5
32
1.64
0.44
1.2
2.6
—
—
—
0
0
(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma
11
80
1.51
0.44
3.9
2.2
mg/l
3.4
3.2
0.10
11
68
(3001122) Ferritin [Mass/volume] in Serum or Plasma
17
136
1.42
0.43
6.5
2.3
ug/l
207.1
104.0
0.62
17
119
(3016251) Hemoglobin.gastrointestinal [Presence] in Stool
0
16
0.00
0.42
0.0
2.9
—
—
—
0
0
(40760892) CBC W Ordered Manual Differential panel - Blood
11
81
1.49
0.41
14.1
3.8
—
—
—
0
0
(3026008) Bacteria identified in Urine by Culture
13
101
1.42
0.37
2.9
3.2
—
—
—
0
0
(3030467) Casts [#/volume] in Urine by Automated count
13
101
1.42
0.37
5.2
2.8
e6/l
0.2
0.5
0.43
13
70
(3041096) Erythrocytes [Presence] in Urine by Automated
8
107
0.69
0.34
3.1
3.5
—
—
—
0
0
(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma
8
63
1.33
0.30
1.8
4.2
mmol/l
2.4
2.5
—
8
54
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
12
143
0.77
0.23
5.0
3.8
—
—
—
0
0
(3002256) Pathology report gross observation
5
41
1.25
0.23
1.6
1.3
—
—
—
0
0
(3010130) Cytomegalovirus IgG Ab [Units/volume] in Serum or Plasma
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
(40768804) Tissue Pathology biopsy report
17
148
1.25
0.21
3.1
2.0
—
—
—
0
0
(46235355) HIV 1 and 2 tests - Meaningful Use set
6
48
1.29
0.21
1.8
1.9
—
—
—
0
0
(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
(3017895) Helicobacter pylori Ab [Units/volume] in Serum
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
(3016879) Cocaine [Presence] in Urine
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
(3023421) Hepatitis B virus surface Ab [Units/volume] in Serum
0
13
0.00
0.21
0.0
1.4
—
162.7
—
0
8
(1761482) Bacteria [#/volume] in Urine by Culture
0
13
0.00
0.21
0.0
4.0
—
—
—
0
0
(1002224) Polysomnography panel
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
18
159
1.23
0.19
7.0
3.7
—
—
—
0
0
(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma
20
179
1.22
0.19
8.3
7.0
umol/l
9.2
11.1
0.56
20
166
(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma
24
260
0.82
0.18
6.8
4.0
pmol/l
15.6
15.2
0.29
24
229
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
12
136
0.84
0.13
2.9
1.8
pmol/l
77.9
101.2
—
7
64
(3021601) Nitrite [Presence] in Urine by Test strip
19
177
1.13
0.08
6.0
4.6
estimate
0.0
0.0
—
5
41
(3031040) Bacteria [#/volume] in Urine by Automated count
21
221
0.90
0.06
6.9
4.2
—
9.3
—
0
6
(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma
12
111
1.11
0.04
3.3
2.2
u/l
48.8
55.8
0.40
12
100
(3009542) Hematocrit [Volume Fraction] of Blood
30
307
0.92
0.02
27.6
14.1
%
40.8
39.4
0.47
20
217
(3009261) Glucose [Presence] in Urine by Test strip
19
183
1.07
0.02
4.6
3.6
estimate
0.0
0.0
—
5
39
(3044889) 12 lead EKG panel
25
244
1.06
0.01
5.4
3.7
—
—
—
0
0
(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma
14
139
1.01
0.00
6.6
4.0
ng/l
98.2
43.3
—
9
96
(3013512) EKG study
10
103
0.96
0.00
5.1
3.9
—
—
—
0
0
(3035285) Chloride [Moles/volume] in Venous blood
0
5
0.00
0.00
0.0
3.4
—
105.2
—
0
5
(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
(3050238) Crystals [Presence] in Synovial fluid by Light microscopy
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(1001926) Buprenorphine [Presence] in Urine by Screen method
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
(3016650) Hepatitis A virus Ab [Presence] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.5
—
2.8
—
0
6
(36306090) Helicobacter pylori [Presence] in Tissue by Organism specific culture
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay
0
7
0.00
0.00
0.0
6.1
—
92.8
—
0
7
(40768793) Breast Pathology biopsy report
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
(40768800) Prostate Pathology biopsy report
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.2
—
17.9
—
0
5
(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
(3041354) Potassium [Moles/volume] in Venous blood
0
5
0.00
0.00
0.0
3.4
—
3.8
—
0
5
(4094501)
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3039443) Prostate specific Ag panel - Serum or Plasma
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
(44816559) Phosphatidylethanol [Mass/volume] in Blood
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
(3004616) Nuclear Ab [Presence] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
(3025839) Triglyceride [Moles/volume] in Serum or Plasma
9
90
1.00
0.00
1.6
1.7
mmol/l
1.5
1.3
—
9
75
(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3035999) Lactate [Moles/volume] in Cerebral spinal fluid
0
6
0.00
0.00
0.0
1.0
—
1.6
—
0
6
(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(3044290) Cell count panel - Cerebral spinal fluid
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3033705) Calcium.ionized [Moles/volume] in Venous blood
0
5
0.00
0.00
0.0
3.4
—
—
—
0
0
(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3032773) Endomysium IgG Ab [Titer] in Serum
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma
0
9
0.00
0.00
0.0
1.7
—
41.3
—
0
9
(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.2
—
0.9
—
0
5
(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma
0
9
0.00
0.00
0.0
2.9
—
19.3
—
0
9
(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3023183) Ammonium ion [Moles/volume] in Plasma
0
6
0.00
0.00
0.0
2.2
—
38.0
—
0
6
Mortality – FinRegistry
↥Association
Association between endpoint E4_AMYL_NONNEURO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_AMYL_NONNEURO | 8.55 [5.5, 13.29] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.112 |
During the follow-up period (1.1.1998 — 31.12.2019), 88 out of 152 females with E4_AMYL_NONNEURO died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have E4_AMYL_NONNEURO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.804% | No data |
| 5 | 4.461% | No data |
| 10 | 10.862% | No data |
| 15 | 19.995% | No data |
| 20 | 33.185% | No data |
Relationships between endpoints
↥Index endpoint: E4_AMYL_NONNEURO – Non-neuropathic heredofamilial amyloidosis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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