amyloidosis: A disorder characterized by the localized or diffuse accumulation of amyloid protein in various anatomic sites. It may be primary, due to clonal plasma cell proliferations; secondary, due to long standing infections, chronic inflammatory disorders, or malignancies; or familial. It may affect the nerves, skin, tongue, joints, heart, liver, spleen, kidneys and adrenal glands.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
109 |
4. Check minimum number of eventsNone |
109 |
5. Include endpointsNone |
109 |
6. Filter based on genotype QC (FinnGen only) |
106 |
Control definitions (FinnGen only)
- Control exclude
- E4_METABOLIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E85
- Name in latin
- Amyloidosis systemica secundaria
Similar endpoints
↥List of similar endpoints to
Secondary systemic amyloidosis
based on the number of shared cases.
Similar with more cases:
- Amyloidosis
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1290 | 873 | 392 |
| Only index persons | 670 | 472 | 198 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.01 |
| Only index persons | 0.01 | 0.02 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 66.38 | 66.66 | 65.34 |
| Only index persons | 64.41 | 64.70 | 63.72 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 106 | 65 | 41 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 62.63 | 60.49 | 66.03 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 109
- Matched controls
- 1090
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E85.3
ICD-10 Finland
Secondary systemic amyloidosis
+∞
148.9
106
*
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
41.0
88.4
69
44
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
39.1
86.6
81
75
L01BA01
ATC
methotrexate; systemic
57.6
84.0
52
17
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
27.7
56.3
44
26
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
21.4
47.9
42
31
7140A
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SEROPOSITIVA]
105.3
45.9
48
8
E85.9
ICD-10 Finland
Amyloidosis, unspecified
+∞
42.5
38
*
71238
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Arthritis rheumatoides alia definita
168.0
42.3
42
*
N08.4*E85.9
ICD-10 Finland
Glomerular disorders in amyloidosis
+∞
40.1
36
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
127.0
34.1
35
*
71239
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Arthritis rheumatoides NUD
136.1
29.3
30
*
A07EC01
ATC
sulfasalazine; oral, rectal
10.9
29.3
39
53
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
85.4
28.7
31
5
L04AX01
ATC
azathioprine; systemic
35.1
28.0
36
15
A11CC03
ATC
alfacalcidol; systemic
97.4
27.3
29
*
L04AX03
ATC
methotrexate; systemic
9.8
27.3
40
61
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
53.3
26.6
31
8
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
11.6
25.9
31
36
L04AA01
ATC
[U] ciclosporin
320.5
25.8
25
*
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
24.1
23.8
34
20
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
24.1
23.8
34
20
C03CA01
ATC
furosemide; systemic
6.8
21.5
75
266
A49.9
ICD-10 Finland
Bacterial infection, unspecified
8.0
20.8
35
61
A12AA04
ATC
calcium carbonate; oral
72.0
20.8
23
*
Z49.1
ICD-10 Finland
Extracorporeal dialysis
90.8
20.5
22
*
2773B
ICD-9 Finland
Other and unspecified disorders of metabolism, Amyloidosis[AMYLOIDOSIS SECUNDARIA]
+∞
20.4
19
*
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
39.9
20.3
25
8
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
85.7
19.5
21
*
71200
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Juvenile rheumatoid arthritis
+∞
19.3
18
*
M08.0
ICD-10 Finland
Juvenile rheumatoid arthritis
+∞
19.3
18
*
TK800
NOMESCO Finland
Hemodialysis
37.9
19.3
24
8
L04AA13
ATC
[U] leflunomide
37.9
19.3
24
8
P01BA02
ATC
hydroxychloroquine; oral
7.6
19.1
33
59
N18.0
ICD-10 Finland
End-stage renal disease
113.9
18.2
19
*
B03XA01
ATC
erythropoietin; parenteral
213.2
18.1
18
*
9283
FHL
Subtalar joint ossification surgery (or triple)
+∞
16.0
15
*
N08.4
ICD-10 Finland
Glomerular disorders in other endocrine, nutritional and metabolic diseases
+∞
16.0
15
*
M05BA04
ATC
alendronic acid; oral
6.1
15.5
33
72
A46
ICD-10 Finland
Erysipelas
5.8
15.3
36
86
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
5.0
15.2
71
296
ZX120
NOMESCO Finland
Intravenous
6.4
15.1
30
61
L88
ICPC
Rheumatoid/seropositive arthritis
15.1
15.0
25
21
9314
FHL
Total knee endoprosthesis (also includes patellar part)
93.0
15.0
16
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
6.1
14.9
32
70
H02AB07
ATC
prednisone; oral
5.7
14.8
35
84
N02AX02
ATC
tramadol; systemic, rectal
4.9
14.7
72
310
M01CB01
ATC
sodium aurothiomalate; parenteral
35.5
14.4
18
6
J01FF01
ATC
clindamycin; systemic
4.6
14.1
54
191
D06BB04
ATC
podophyllotoxin; topical
19.6
14.1
21
13
I50.9
ICD-10 Finland
Heart failure, unspecified
5.1
14.0
39
107
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
16.9
14.0
22
16
L04AC07
ATC
tocilizumab; parenteral
+∞
13.8
13
*
L01AA02
ATC
chlorambucil; oral
159.0
13.8
14
*
NF1AA
NOMESCO Finland
Hip X-ray examination
6.0
13.8
29
62
9294
FHL
Endoprosthesis replacement of the entire hip joint (eg Charnley)
46.3
13.6
16
*
H02AB04
ATC
methylprednisolone; systemic
5.0
13.5
38
105
H02AB06
ATC
prednisolone; systemic
4.8
13.1
78
377
N19
ICD-10 Finland
Unspecified kidney failure
20.6
13.1
19
11
ZXD05
NOMESCO Finland
Urgent procedure
4.3
12.9
52
189
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
10.8
12.9
25
29
Z94.0
ICD-10 Finland
Kidney transplant status
+∞
12.7
12
*
7140B
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SERONEGATIVA]
+∞
12.7
12
*
M08.3
ICD-10 Finland
Juvenile polyarthritis (seronegative)
+∞
12.7
12
*
9273
FHL
Other surgery for toe deformity or pain condition, e.g., Morton, hammer toe
146.1
12.7
13
*
9256
FHL
Synovectomy (knee 9311)
146.1
12.7
13
*
V03AE01
ATC
polystyrene sulfonate; oral
43.0
12.6
15
*
NA1EA
NOMESCO Finland
Cervical spine X-ray examination with flexion
43.0
12.6
15
*
M04AA01
ATC
allopurinol; systemic
4.9
12.1
34
93
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.6
12.0
37
109
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
6.6
11.7
21
38
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
+∞
11.7
11
*
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
6.1
11.6
23
46
L04AB04
ATC
adalimumab; parenteral
39.7
11.6
14
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.0
11.5
53
209
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
28.6
11.5
15
6
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
6.2
11.3
22
43
ZXA05
NOMESCO Finland
Left side
4.0
11.3
49
185
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
4.9
11.1
30
79
N17.9
ICD-10 Finland
Acute renal failure, unspecified
20.5
11.1
16
9
B03XA02
ATC
darbepoetin alfa; parenteral
31.7
11.0
14
5
C90.0
ICD-10 Finland
Multiple myeloma
24.5
11.0
15
7
L04AB01
ATC
etanercept; parenteral
66.7
10.9
12
*
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
66.7
10.9
12
*
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
11.4
10.8
20
21
B01AB04
ATC
dalteparin; parenteral
10.1
10.7
21
25
127
Kela drug reimbursment
Transplant complication
121.2
10.6
11
*
NHG20
NOMESCO Finland
Fusion of talocrural joint
121.2
10.6
11
*
E85.0
ICD-10 Finland
Non-neuropathic heredofamilial amyloidosis
+∞
10.6
10
*
NDG74
NOMESCO Finland
Fusion of first IP joint
+∞
10.6
10
*
L04AA11
ATC
[U] etanercept
+∞
10.6
10
*
J01MA12
ATC
levofloxacin; systemic
4.0
10.4
40
138
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
5.4
10.3
23
51
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
14.1
10.3
17
14
I50.0
ICD-10 Finland
Congestive heart failure
5.3
10.1
23
52
N18.8
ICD-10 Finland
Other chronic renal failure
22.6
10.1
14
7
9272
FHL
Metatarsophalangeal joint resection
60.5
9.8
11
*
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
12.3
9.7
17
16
NHG76
NOMESCO Finland
Arthroplasty of other tarsometatarsal joint
19.8
9.7
14
8
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
33.3
9.6
12
*
9503
FHL
Tendon or tendon sheath cleansing surgery (tenosynovectomy)
109.1
9.6
10
*
ZZH31
NOMESCO Finland
Bone allograft, small pieces
109.1
9.6
10
*
7143C
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Juvenile chronic polyarthritis[POLYARTHRITIS JUVENILIS SERONEGATIVA]
+∞
9.5
9
*
NCB20
NOMESCO Finland
Primary total prosthetic replacement of elbow joint
+∞
9.5
9
*
137
Kela drug reimbursment
Uraemia requiring dialysis
+∞
9.5
9
*
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
8.8
9.5
20
27
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
8.5
9.3
20
28
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
10.0
9.2
18
21
H26.2
ICD-10 Finland
Complicated cataract
40.3
9.2
11
*
9732/3-C42.1
ICD-O-3
Plasma cell myeloma of bone marrow
26.7
9.1
12
5
ZXE20
NOMESCO Finland
More than three and less than five hours
4.0
9.0
32
103
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
15.8
9.0
14
10
NFC40
NOMESCO Finland
Repair of hip prosthesis by bone transplant to acetabulum
54.5
8.8
10
*
M01CB03
ATC
auranofin; oral
54.5
8.8
10
*
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
18.2
8.8
13
8
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
9.1
8.8
18
23
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
9.1
8.8
18
23
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
8.3
8.7
19
27
A07AA09
ATC
vancomycin; oral
97.3
8.5
9
*
9284
FHL
Wrist ossification surgery
97.3
8.5
9
*
M05
ICD-10 Finland
Seropositive rheumatoid arthritis
97.3
8.5
9
*
NHG24
NOMESCO Finland
Fusion of subtalar joint and between bones of ankle
97.3
8.5
9
*
NGB40
NOMESCO Finland
Primary total prosthetic replacement of knee joint with patellar part - sliding prosthesis
9.4
8.5
17
21
V03AE02
ATC
sevelamer; oral
+∞
8.4
8
*
9289
FHL
Other measure in this category
+∞
8.4
8
*
E85.4
ICD-10 Finland
Organ-limited amyloidosis
+∞
8.4
8
*
PG5RT
NOMESCO Finland
PTA of arterio-venous shunt for dialysis
+∞
8.4
8
*
L01BB01, ,
ATC
+∞
8.4
8
*
L04AA17
ATC
[U] adalimumab
+∞
8.4
8
*
L01CB
ATC
Podophyllotoxin derivatives
+∞
8.4
8
*
NC1AA
NOMESCO Finland
Elbow X-ray examination without contrast
11.4
8.3
15
15
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.3
8.3
69
375
L04AX04
ATC
lenalidomide; oral
36.3
8.2
10
*
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
4.0
8.2
28
87
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
4.0
7.8
26
79
Z49.0
ICD-10 Finland
Preparatory care for dialysis
48.6
7.8
9
*
H02AB08
ATC
triamcinolone; systemic
48.6
7.8
9
*
R4180
NOMESCO Finland
Podiatric therapy
48.6
7.8
9
*
NHM20
NOMESCO Finland
Excision of synovial ganglion of ankle or foot
48.6
7.8
9
*
NDU20
NOMESCO Finland
Removal of internal fixation device from wrist or hand
20.2
7.8
11
6
L04AA06
ATC
mycophenolic acid; systemic
20.2
7.8
11
6
T84.5
ICD-10 Finland
Infection and inflammatory reaction due to internal joint prosthesis
20.2
7.8
11
6
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
5.1
7.8
18
41
TND11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in joint, wrist or hand
27.2
7.7
10
*
L04AD01
ATC
ciclosporin; systemic
27.2
7.7
10
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
8.7
7.7
16
21
M05BX04
ATC
denosumab; parenteral
6.7
7.7
19
33
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.1
7.6
46
206
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.5
7.6
33
121
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
85.7
7.5
8
*
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
85.7
7.5
8
*
R50.9
ICD-10 Finland
Fever, unspecified
3.8
7.5
27
87
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
17.3
7.4
11
7
9531
FHL
Arthrodesis of the hand joint
+∞
7.4
7
*
E85.89
ICD-10 Finland
Other amyloidosis
+∞
7.4
7
*
NDG77
NOMESCO Finland
Other excision, reconstruction or fusion of joint of first finger
+∞
7.4
7
*
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
+∞
7.4
7
*
A12AA12
ATC
[U] calcium acetate
+∞
7.4
7
*
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
+∞
7.4
7
*
M08.4
ICD-10 Finland
Pauciarticular juvenile arthritis
+∞
7.4
7
*
153
Kela drug reimbursment
Lenalidomid
32.4
7.3
9
*
NDG30
NOMESCO Finland
Fusion of wrist, total
32.4
7.3
9
*
M05BA07
ATC
risedronic acid; oral
7.6
7.1
16
24
ZXE10
NOMESCO Finland
More than one and less than three hours
2.9
7.0
55
282
XW000
NOMESCO Finland
Bone marrow biopsy
8.1
7.0
15
21
B01AA03
ATC
warfarin; systemic
3.2
7.0
36
146
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
18.1
6.9
10
6
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.7
6.8
17
41
B01AB05
ATC
enoxaparin; parenteral
2.9
6.7
49
240
M01AH02
ATC
rofecoxib; oral
3.5
6.7
28
99
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
4.0
6.7
21
61
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
3.5
6.6
27
94
J01DA01
ATC
[U] cefalexin
3.2
6.6
82
532
NHG80
NOMESCO Finland
Fusion of first tarsometatarsal joint
7.4
6.6
15
23
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
4.4
6.6
18
47
ZXA00
NOMESCO Finland
Right side
2.9
6.6
44
206
WW200
NOMESCO Finland
Immunization
15.5
6.5
10
7
NAG42
NOMESCO Finland
Posterior fusion of cervical spine with or without fixation
74.0
6.5
7
*
NHG22
NOMESCO Finland
Fusion of subtalar joint
74.0
6.5
7
*
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
10.2
6.5
12
13
WZA10
NOMESCO Finland
Extensive medical or dental certificate
19.4
6.4
9
5
KA1AE
NOMESCO Finland
Kidney ultrasound examination
19.4
6.4
9
5
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
4.1
6.4
19
53
TPX10
NOMESCO Finland
Implantation of vascular injection port
8.5
6.3
13
17
L01AA01
ATC
cyclophosphamide; systemic
28.5
6.3
8
*
E87.5
ICD-10 Finland
Hyperkalaemia
+∞
6.3
6
*
NDB60
NOMESCO Finland
Prosthetic replacement of MCP joint of finger
+∞
6.3
6
*
N084, E853,
ICD-10 Finland
+∞
6.3
6
*
M43.4
ICD-10 Finland
Other recurrent atlantoaxial subluxation
+∞
6.3
6
*
27699
ICD-8 Finland
Amyloidosis
+∞
6.3
6
*
NHB10
NOMESCO Finland
Primary partial prosthetic replacement of ankle joint
+∞
6.3
6
*
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
4.1
6.2
19
54
TPH04
NOMESCO Finland
Cathetrisation of vein
3.1
6.2
32
129
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
6.1
6.1
16
30
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
8.0
6.1
13
18
M01AB01
ATC
indometacin; systemic, rectal
4.3
6.1
17
45
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
42
119
5.12
14.61
5.0
2.0
1.93
2.30
g/l
3.84
42
106
32
73
5.79
14.22
5.5
2.2
60.26
65.31
g/l
1.79
27
64
43
129
4.85
13.86
5.2
2.0
9.20
12.98
umol/l
2.59
43
119
26
66
4.86
10.00
2.6
1.4
—
—
—
0
0
17
17
11.61
9.42
2.2
2.1
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
15
13
13.16
8.89
3.3
2.3
0.21
0.38
u/ml
—
9
8
48
213
3.24
8.14
4.7
2.5
9866.77
7557.28
umol/l
0.09
43
169
24
67
4.31
8.12
2.5
3.0
45.38
63.62
ml/min/173m2
0.88
13
29
10
5
21.80
7.28
2.6
1.2
—
—
—
0
0
14
21
7.48
6.27
1.9
1.3
—
—
—
0
0
68
417
2.68
5.78
25.7
4.8
1.20
1.22
mmol/l
0.90
61
348
18
52
3.95
5.74
5.8
2.2
0.73
1.91
mmol/l
0.54
12
45
54
311
2.46
5.04
6.9
3.0
—
—
—
0
0
15
34
4.94
4.97
9.8
2.7
24.40
24.77
mmol/l
0.13
15
34
10
13
8.34
4.97
1.8
1.3
—
—
—
0
0
12
22
5.99
4.76
2.0
1.8
—
—
—
0
0
23
89
3.01
4.67
2.2
1.6
—
—
—
0
0
29
132
2.63
4.36
2.9
1.7
—
—
—
0
0
14
35
4.43
4.29
9.0
1.7
—
—
—
0
0
11
23
5.19
3.99
3.0
1.7
—
—
—
0
0
22
92
2.74
3.86
2.3
1.6
—
—
—
0
0
14
40
3.86
3.77
11.1
2.8
48.97
45.93
%
0.14
14
40
9
19
5.06
3.32
3.0
1.6
—
—
—
0
0
51
327
2.05
3.31
5.0
3.9
91.80
46.90
ng/l
1.04
39
250
6
7
8.98
3.30
1.2
1.3
—
—
—
0
0
6
7
8.98
3.30
1.2
1.3
—
—
—
0
0
75
903
0.46
3.29
76.1
21.4
36.45
39.45
%
5.80
70
841
11
29
4.10
3.29
1.5
1.1
—
—
—
0
0
62
794
0.49
3.18
46.1
13.8
61.25
75.31
ml/min/173m2
2.65
55
654
10
25
4.29
3.17
2.9
1.6
—
—
—
0
0
65
819
0.49
3.16
4.0
4.7
5.37
5.94
mmol/l
5.98
59
725
9
21
4.57
3.07
1.0
1.3
0.25
0.20
g/l
—
9
21
12
39
3.33
2.88
2.5
4.0
—
—
—
0
0
54
367
1.93
2.87
4.3
2.5
—
—
—
0
0
20
96
2.33
2.63
9.1
4.6
2.38
1.09
mmol/l
0.51
15
79
5
7
7.41
2.57
2.8
2.3
—
—
—
0
0
5
7
7.41
2.57
2.8
2.3
—
—
—
0
0
5
7
7.41
2.57
2.8
2.3
—
—
—
0
0
6
12
5.22
2.43
1.8
1.1
—
—
—
0
0
7
17
4.32
2.40
1.0
1.9
—
—
—
0
0
69
829
0.54
2.31
5.2
5.0
2.51
2.72
mmol/l
1.47
64
741
5
9
5.76
2.23
3.4
1.2
—
—
—
0
0
30
180
1.92
2.23
2.0
1.5
5.57
1.14
mg/l
0.71
23
139
67
808
0.56
2.19
5.1
4.5
4.51
4.66
mmol/l
0.71
62
728
6
14
4.47
2.18
1.5
1.1
—
—
—
0
0
6
14
4.47
2.18
2.7
1.9
—
—
—
0
0
6
14
4.47
2.18
2.7
1.9
—
—
—
0
0
10
37
2.87
2.13
4.3
2.3
0.86
0.68
%
—
10
37
7
20
3.67
2.09
6.7
3.1
60.71
58.95
%
—
7
20
20
106
2.09
2.08
15.4
4.3
102.65
103.76
mmol/l
0.56
20
106
67
804
0.57
2.07
5.0
4.4
1.54
1.54
mmol/l
0.00
62
719
10
38
2.79
2.06
4.3
2.3
1.15
1.21
%
—
10
38
24
137
1.96
2.05
4.8
3.0
3.13
2.36
e6/l
0.19
19
74
54
397
1.71
2.02
10.3
3.8
0.00
0.00
estimate
-0.00
16
88
54
397
1.71
2.02
13.3
4.8
0.00
0.00
estimate
-0.00
15
78
30
186
1.85
2.00
4.2
2.4
—
—
—
0
0
7
21
3.49
2.00
1.9
1.1
—
—
—
0
0
54
402
1.68
1.90
10.4
3.9
0.00
0.00
estimate
-0.00
15
78
25
149
1.88
1.88
3.9
2.8
0.58
0.96
e6/l
0.81
20
85
6
17
3.67
1.86
3.0
1.4
—
—
—
0
0
6
17
3.67
1.86
1.5
1.4
—
—
—
0
0
6
17
3.67
1.86
1.5
1.4
—
—
—
0
0
5
12
4.31
1.84
2.8
1.9
—
—
—
0
0
65
777
0.60
1.82
5.1
3.9
1.33
1.23
mmol/l
0.64
60
695
56
425
1.65
1.80
25.5
13.1
1.16
1.31
inr
0.70
12
129
6
18
3.46
1.77
2.5
1.8
—
—
—
0
0
6
18
3.46
1.77
1.3
1.4
—
—
—
0
0
5
13
3.98
1.73
1.2
1.2
—
—
—
0
0
5
13
3.98
1.73
3.4
1.3
—
—
—
0
0
38
266
1.66
1.64
6.0
3.4
63.36
5.85
mg/mmol
1.86
30
155
7
26
2.80
1.61
1.1
1.9
—
—
—
0
0
5
15
3.44
1.54
2.8
1.7
—
—
—
0
0
41
308
1.53
1.28
11.5
4.0
—
—
—
0
0
29
397
0.63
1.28
2.9
2.4
—
—
—
0
0
11
56
2.07
1.27
9.4
4.8
92.85
94.59
%
0.76
11
56
15
87
1.84
1.22
11.3
3.6
1.25
1.23
mmol/l
0.66
15
73
11
57
2.03
1.22
2.6
1.4
—
—
—
0
0
16
96
1.78
1.18
5.7
3.9
—
—
—
0
0
7
34
2.13
1.05
4.9
2.1
—
—
—
0
0
31
229
1.49
1.03
12.3
4.4
0.00
0.00
estimate
—
10
79
26
185
1.53
1.02
1.8
1.8
1126.36
1372.94
nmol/l
0.59
20
140
34
258
1.46
0.98
3.4
2.2
72.85
74.06
u/l
0.02
34
238
13
203
0.59
0.96
2.2
4.9
17.97
20.92
%
—
6
107
6
29
2.13
0.91
1.7
1.3
—
—
—
0
0
6
31
1.99
0.86
4.0
1.9
—
—
—
0
0
21
153
1.46
0.74
4.5
3.2
460.00
206.79
ng/l
0.39
21
126
7
40
1.80
0.73
11.1
4.4
23.23
24.73
mmol/l
—
7
40
7
116
0.58
0.73
3.6
4.1
39.86
33.90
%
—
7
69
73
658
1.33
0.67
22.7
7.4
78.66
80.36
u/l
0.13
73
599
8
49
1.68
0.64
2.0
1.5
—
—
—
0
0
15
107
1.47
0.59
22.6
7.3
—
—
—
0
0
6
39
1.57
0.54
1.2
2.4
31.20
37.55
u/l
—
6
34
5
36
1.41
0.38
2.2
1.1
—
—
—
0
0
5
36
1.41
0.38
2.2
1.1
—
—
—
0
0
41
365
1.20
0.35
2.1
1.9
100.57
98.34
pmol/l
0.09
27
163
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
9
114
0.77
0.21
1.3
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
4.1
—
30.77
—
0
13
6
49
1.24
0.20
2.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.9
—
—
—
0
0
12
100
1.22
0.19
2.2
1.4
—
—
—
0
0
15
166
0.89
0.10
1.1
1.2
1.20
1.88
u/ml
—
5
39
15
140
1.08
0.04
1.1
1.3
62.11
45.68
iu/ml
—
9
52
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
4.56
—
0
5
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_AMYL_SCNDSYST and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_AMYL_SCNDSYST | 7.651 [6.33, 9.25] | < 0.001 |
| Birth year | 1.0 [0.99, 1.01] | 0.982 |
During the follow-up period (1.1.1998 — 31.12.2019), 408 out of 583 females with E4_AMYL_SCNDSYST died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_AMYL_SCNDSYST | 6.313 [4.57, 8.71] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.024 |
During the follow-up period (1.1.1998 — 31.12.2019), 207 out of 270 males with E4_AMYL_SCNDSYST died.
Mortality risk
Mortality risk for people of age
years, who have E4_AMYL_SCNDSYST.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.594% | 1.358% |
| 5 | 4.313% | 7.536% |
| 10 | 11.776% | 18.552% |
| 15 | 22.493% | 31.996% |
| 20 | 36.046% | 49.217% |
Relationships between endpoints
↥Index endpoint: E4_AMYL_SCNDSYST – Secondary systemic amyloidosis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data