Hyperchylomicronaemia

E4_HYPERCHYLO

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E78.3 Hospital discharge: ICD-9 — 2723 Cause of death: ICD-10 — E78.3 Cause of death: ICD-9 — 2723 2 out of 7 registries used, show all original rules.	71
4. Check minimum number of events None	71
5. Include endpoints None	71
6. Filter based on genotype QC (FinnGen only)	71

Control definitions (FinnGen only)

Control exclude: E4_METABOLIA

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: E78
Name in latin: Hyperchylomicronaemia

NAME	E4_HYPERCHYLO
CONTROL_EXCLUDE	E4_METABOLIA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E783
HD_ICD_9	2723
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E783
COD_ICD_9	2723
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Hyperchylomicronaemia based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	525	214	310
Only index persons	487	196	291
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	61.99	67.95	57.98
Only index persons	61.43	66.74	57.86

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	71	26	45
Unadjusted period prevalence (%)	0.02	0.01	0.02
Median age at first event (years)	57.36	61.20	55.15

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
68: Matched controls
678

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

E78.3

ICD-10 Finland

Hyperchylomicronaemia

+∞

89.9

E78.5

ICD-10 Finland

Hyperlipidaemia, unspecified

49.4

17.9

I25.1

ICD-10 Finland

Atherosclerotic heart disease

10.2

16.0

206

Kela drug reimbursment

Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease

8.9

13.0

C10AB02

ATC

bezafibrate; oral

+∞

11.8

E78.01

ICD-10 Finland

Pure hypercholesterolaemia

11.9

11.7

C10AB05

ATC

fenofibrate; oral

52.7

11.4

A10BA02

ATC

metformin; oral

6.2

10.8

110

E11.9

ICD-10 Finland

Type 2 diabetes mellitus, without complications

6.6

10.8

E78.00

ICD-10 Finland

Familial hypercholesterolaemia

+∞

10.7

103

Kela drug reimbursment

Diabetes, insulin-treated

5.9

10.4

114

C10AX09

ATC

ezetimibe; oral

13.1

10.3

C10AA05

ATC

atorvastatin; oral

5.6

10.2

160

C10AA01

ATC

simvastatin; oral

5.6

10.2

185

215

Kela drug reimbursment

Diabetes, non-insulin-treated

5.9

10.0

E78.9

ICD-10 Finland

Disorder of lipoprotein metabolism, unspecified

+∞

9.6

I25.9

ICD-10 Finland

Chronic ischaemic heart disease, unspecified

8.2

9.1

C10AA07

ATC

rosuvastatin; oral

5.6

8.7

B01AC04

ATC

clopidogrel; oral

6.9

8.7

C10AA04

ATC

fluvastatin; oral

11.2

8.6

C01DA14

ATC

isosorbide mononitrate; oral

6.6

8.4

C01DA08

ATC

isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal

5.0

7.8

I20.09

ICD-10 Finland

Unstable angina

13.1

7.7

E78.29

ICD-10 Finland

Other mixed hyperlipidaemia

+∞

7.4

E11.7

ICD-10 Finland

Type 2 diabetes mellitus, with multiple complications

14.2

7.4

T90

ICPC

Diabetes non-insulin dependent

4.9

7.4

A10BJ06

ATC

semaglutide; parenteral

44.6

6.9

Angiography of the heart and coronary arteries

11.8

6.9

FN1AC

NOMESCO Finland

Angiography of heart and/or coronary arteries

4.6

6.7

XF402

NOMESCO Finland

ECG with work load test

6.1

6.3

SPAT1250

SPAT

Comprehensive monitoring of chronic illness

3.9

6.3

119

285

Kela drug reimbursment

Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)

17.0

6.1

I20.81

ICD-10 Finland

Other angina pectoris stenosed coronary artery

7.4

6.1

Z95.1

ICD-10 Finland

Presence of aortocoronary bypass graft

12.8

6.0

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3012516) Albumin [Mass/volume] in Urine

166

4.75

9.70

5.8

2.8

mg/l

248.5

36.3

1.94

115

(3009508) Creatinine [Moles/volume] in Urine

172

4.53

9.12

6.6

2.6

mmol/l

6.6

8.4

2.52

138

(3020682) Albumin/Creatinine [Ratio] in Urine

180

4.52

9.04

6.9

3.4

mg/mmol

76.1

6.2

1.41

117

(3022948) Iron [Moles/volume] in Serum or Plasma

3.61

5.65

7.0

1.5

umol/l

10.5

15.1

1.78

(4034850)

5.66

4.94

8.6

16.3

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

225

2.95

4.74

6.2

4.2

ng/l

36.9

42.8

0.20

167

(3034770) Mitochondria Ab [Titer] in Serum

9.17

4.72

1.1

—

(3007164) IgA [Mass/volume] in Serum or Plasma

2.96

4.04

1.3

1.6

g/l

2.5

3.1

0.37

(3003396) Base excess in Arterial blood by calculation

3.26

4.03

9.8

3.7

mmol/l

2.1

1.3

0.35

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

132

2.69

3.71

4.3

2.2

—

(3023368) Bacteria identified in Blood by Culture

149

2.60

3.59

6.2

4.1

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

158

2.56

3.52

3.2

1.9

u/l

167.0

186.4

0.15

148

(3013826) Glucose [Moles/volume] in Serum or Plasma

334

2.51

3.18

9.7

4.0

mmol/l

8.5

6.8

3.46

311

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

3.85

3.18

7.4

3.8

mmol/l

25.2

25.1

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

2.94

3.14

25.1

2.3

mmol/l

1.2

1.1

0.37

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

8.06

3.12

1.7

1.1

—

(3000991) Gas panel - Venous blood

3.16

3.00

17.8

3.4

—

(3014007) Fractional oxyhemoglobin in Arterial blood

3.15

2.81

11.5

3.4

94.3

92.9

0.36

(3004119) Hemoglobin [Mass/volume] in Venous blood

3.47

2.77

6.0

2.2

g/l

110.8

132.9

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.96

2.71

3.0

1.6

—

(3012544) pH of Venous blood

3.01

2.60

13.8

2.8

—

(40760888) Immunoglobulin light chains.free panel - Serum

5.84

2.60

1.2

1.5

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

2.72

2.36

2.9

1.5

—

(3032080) INR in Blood by Coagulation assay

236

2.07

2.31

12.2

9.1

inr

1.1

1.3

—

(3019060) Gas panel - Arterial blood

2.92

2.31

7.5

2.6

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

3.62

2.26

12.1

5.8

—

(3037467) Urinalysis macro (dipstick) panel - Urine

383

2.18

2.25

5.5

3.9

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

257

2.03

2.21

6.1

3.8

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

3.97

2.21

1.0

1.2

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.35

2.18

3.0

1.7

—

(3022217) INR in Platelet poor plasma by Coagulation assay

2.39

2.17

17.7

21.9

—

1.3

—

(3015736) pH of Urine

206

2.01

2.12

3.4

—

(3015235) Bicarbonate [Moles/volume] in Capillary blood

3.76

2.11

3.1

2.3

mmol/l

25.2

25.1

—

(3022914) Cancer Ag 19-9 [Units/volume] in Serum or Plasma

3.58

2.02

2.3

3.3

u/ml

136.4

79.8

—

(3036489) Thrombin time

4.80

1.97

6.8

1.3

24.8

20.2

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.88

1.94

1.7

1.5

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

3.09

1.93

5.1

2.6

mmol/l

25.9

25.2

—

(3026008) Bacteria identified in Urine by Culture

160

1.99

1.92

3.1

2.6

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

461

2.20

1.88

11.5

7.3

u/l

76.6

79.9

0.26

426

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

3.75

1.88

1.3

1.5

g/l

0.3

0.2

—

(3018095) Leukocytes [#/volume] in Urine

213

1.91

1.88

4.8

3.2

e6/l

77.2

36.5

0.26

159

(3022313) Gas panel - Capillary blood

3.26

1.85

10.0

3.1

—

(3044640) Blood type and Crossmatch panel - Blood

171

1.93

1.82

4.4

2.2

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

3.54

1.78

1.5

g/l

1.2

—

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

3.54

1.78

11.0

3.4

mmol/l

24.7

25.7

—

(3035350) Ketones [Presence] in Urine by Test strip

276

1.81

1.64

3.9

3.5

estimate

0.0

—

(3019225) pH of Specimen

2.37

1.60

11.4

4.4

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

2.60

1.59

7.5

3.0

60.1

46.5

—

(21494755) Public health laboratory ask at order entry panel

0.00

1.58

0.0

1.8

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

3.50

1.55

1.8

2.5

—

(3013290) Carbon dioxide [Partial pressure] in Blood

3.50

1.55

3.4

1.5

kpa

5.0

4.7

—

(3027315) Oxygen [Partial pressure] in Blood

3.50

1.55

3.4

1.5

kpa

9.0

8.5

—

(36304419) Bacteria [Presence] in Urine

162

1.84

1.54

4.1

2.5

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

2.20

1.48

4.8

5.0

ug/l

7.6

6.0

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

3.28

1.46

2.0

1.8

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

227

1.75

1.45

2.4

1.9

pmol/l

107.5

95.3

0.59

107

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.56

1.43

2.1

1.6

—

(3009261) Glucose [Presence] in Urine by Test strip

284

1.73

1.43

4.0

3.5

estimate

0.0

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

3.08

1.38

2.0

2.2

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

109

1.87

1.35

3.2

1.4

mg/l

3.9

1.1

0.82

(3022145) Colonoscopy Study observation

2.09

1.32

1.4

1.2

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

2.75

1.23

2.0

1.8

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.24

1.23

1.4

1.3

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

2.24

1.23

2.6

1.9

ng/l

94.9

120.6

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.02

1.22

2.8

1.5

—

(42870588) Differential panel, method unspecified - Blood

191

1.67

1.20

9.4

5.9

—

(3030467) Casts [#/volume] in Urine by Automated count

174

1.67

1.17

4.0

2.4

e6/l

0.1

0.5

2.21

131

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.48

1.16

2.4

2.1

—

(36660697) Celiac disease serology panel - Serum

2.48

1.16

1.4

1.2

—

(3021601) Nitrite [Presence] in Urine by Test strip

279

1.59

1.09

5.4

4.5

estimate

0.0

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

568

1.97

1.08

6.3

4.8

mmol/l

7.2

6.0

4.67

512

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.11

1.03

2.7

1.3

—

(40761535) Cells panel - Urine sediment

1.84

0.96

5.6

3.3

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.79

0.96

5.5

8.4

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

586

1.93

0.88

8.1

5.0

mmol/l

2.0

2.7

5.56

529

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.81

0.80

3.8

1.5

—

(40768443) Skin Pathology biopsy report

2.26

0.78

1.0

1.1

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

2.16

0.76

1.2

1.8

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.69

0.76

4.1

1.4

—

(3042936) Bacteria identified in Isolate by Culture

1.63

0.72

2.8

1.7

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

228

0.67

0.70

3.7

4.5

26.0

20.6

0.66

107

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

222

1.43

0.69

4.0

3.7

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.71

0.69

2.4

3.5

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.71

0.69

3.6

2.0

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

609

1.80

0.68

38.4

16.1

umol/l

108.6

80.4

1.97

609

(3041096) Erythrocytes [Presence] in Urine by Automated

158

1.47

0.68

3.7

3.2

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

560

1.63

0.67

7.0

4.0

mmol/l

2.8

1.3

1.52

503

(3013512) EKG study

195

1.44

0.67

6.1

3.5

—

(4035726)

1.71

0.65

1.3

1.4

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

1.83

0.60

2.5

3.1

e6/l

0.1

—

(3020891) Body temperature

1.78

0.59

18.2

2.5

—

(40768797) Stomach Pathology biopsy report

1.56

0.59

1.2

1.3

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

126

1.46

0.59

4.1

3.6

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

554

1.54

0.58

26.9

13.0

ml/min/173m2

69.4

78.2

1.68

462

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

101

1.48

0.55

9.4

2.6

ng/l

187.9

173.9

0.04

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

185

0.70

0.52

2.5

3.0

ug/l

0.6

0.7

0.24

120

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

571

1.48

0.48

33.4

13.5

mg/l

28.7

22.3

0.56

460

(3029937) Albumin [Presence] in Urine by Test strip

171

1.32

0.42

4.6

3.7

estimate

0.0

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.41

0.0

1.1

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

575

1.43

0.41

7.6

4.5

mmol/l

4.2

4.7

1.90

528

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

575

1.43

0.41

7.8

4.4

mmol/l

1.2

1.5

5.27

523

(40768804) Tissue Pathology biopsy report

229

1.29

0.41

3.4

2.1

—

(3002256) Pathology report gross observation

1.39

0.40

1.4

1.2

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

289

0.79

0.36

4.6

4.9

ug/l

2.1

0.03

254

(40758558) Short blood count panel - Blood

139

1.29

0.33

5.3

5.9

—

(40760892) CBC W Ordered Manual Differential panel - Blood

130

1.30

0.32

3.9

5.9

—

(1761868) Lipid panel - Serum or Plasma

214

0.79

0.32

3.9

2.8

—

(40761536) Microorganisms panel - Urine sediment

1.30

0.31

4.3

3.2

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.33

0.29

1.4

—

(3000494) Fungus identified in Specimen by Culture

1.24

0.28

2.4

1.5

—

(40761511) CBC panel - Blood by Automated count

599

1.28

0.22

30.6

12.9

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.21

0.0

3.9

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.1

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.1

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.1

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.2

—

(40768793) Breast Pathology biopsy report

0.00

0.21

0.0

1.3

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.7

—

(3000492) Spirometry study

1.17

0.19

1.3

1.4

—

(3003694) ABO and Rh group [Type] in Blood

141

0.82

0.18

1.6

1.3

—

(3009542) Hematocrit [Volume Fraction] of Blood

503

0.86

0.18

34.2

12.9

36.2

39.7

0.88

354

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

291

1.12

0.12

3.2

2.9

—

(3044889) 12 lead EKG panel

429

0.95

0.03

5.1

4.0

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.0

5.4

—

28.4

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

2.9

—

2.0

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.90

0.00

1.0

1.4

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.0

1.0

—

(4268621)

0.00

0.0

1.8

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.1

—

5.3

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.0

1.9

—

(3002823) Mycoplasma pneumoniae IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.2

—

(3021387) Prolactin [Units/volume] in Serum or Plasma

0.00

0.0

1.4

—

234.2

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

0.0

1.7

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

1.8

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(4027681)

0.00

0.0

1.3

—

(4306422)

0.00

0.0

1.2

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.2

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.2

—

(3009466) Valproate [Moles/volume] in Serum or Plasma

0.00

0.0

3.2

—

295.7

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.2

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.0

5.0

—

33.2

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

3.2

—

90.6

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

0.00

0.0

1.4

—

136.4

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

0.00

0.0

1.6

—

(3000012) Reticulocyte production index

0.00

0.0

3.2

—

(3037677) Mycoplasma pneumoniae IgM Ab [Titer] in Cerebral spinal fluid

0.00

0.0

1.2

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.2

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.4

—

(3042631) Mycobacterium sp identified in Specimen

0.00

0.0

2.0

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.2

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

3.0

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint E4_HYPERCHYLO and mortality.

Females

Parameter	HR [95% CI]	p-value
E4_HYPERCHYLO	1.618 [1.15, 2.27]	0.005
Birth year	0.996 [0.99, 1.0]	0.346

During the follow-up period (1.1.1998 — 31.12.2019), 56 out of 185 females with E4_HYPERCHYLO died.

Males

Parameter	HR [95% CI]	p-value
E4_HYPERCHYLO	1.441 [1.03, 2.02]	0.035
Birth year	0.986 [0.98, 1.0]	0.004

During the follow-up period (1.1.1998 — 31.12.2019), 72 out of 267 males with E4_HYPERCHYLO died.

Mortality risk

Mortality risk for people of age

years, who have E4_HYPERCHYLO.

N-year risk	Females	Males
1	0.18%	0.268%
5	0.987%	1.735%
10	2.419%	4.267%
15	4.531%	7.504%
20	8.32%	12.569%

Relationships between endpoints

↥

Index endpoint: E4_HYPERCHYLO – Hyperchylomicronaemia

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Hyperchylomicronaemia

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints