No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
71 |
4. Check minimum number of eventsNone |
71 |
5. Include endpointsNone |
71 |
6. Filter based on genotype QC (FinnGen only) |
71 |
Control definitions (FinnGen only)
- Control exclude
- E4_METABOLIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E78
- Name in latin
- Hyperchylomicronaemia
Similar endpoints
↥List of similar endpoints to
Hyperchylomicronaemia
based on the number of shared cases.
Similar with more cases:
- Disorders of lipoprotein metabolism and other lipidaemias
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 525 | 214 | 310 |
| Only index persons | 487 | 196 | 291 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 61.99 | 67.95 | 57.98 |
| Only index persons | 61.43 | 66.74 | 57.86 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 71 | 26 | 45 |
| Unadjusted period prevalence (%) | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | 57.36 | 61.20 | 55.15 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 68
- Matched controls
- 678
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E78.3
ICD-10 Finland
Hyperchylomicronaemia
+∞
89.9
65
*
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
49.4
17.9
21
6
I25.1
ICD-10 Finland
Atherosclerotic heart disease
10.2
16.0
38
75
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
8.9
13.0
31
58
C10AB02
ATC
bezafibrate; oral
+∞
11.8
11
*
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
11.9
11.7
22
26
C10AB05
ATC
fenofibrate; oral
52.7
11.4
13
*
A10BA02
ATC
metformin; oral
6.2
10.8
37
110
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
6.6
10.8
33
85
E78.00
ICD-10 Finland
Familial hypercholesterolaemia
+∞
10.7
10
*
103
Kela drug reimbursment
Diabetes, insulin-treated
5.9
10.4
37
114
C10AX09
ATC
ezetimibe; oral
13.1
10.3
18
18
C10AA05
ATC
atorvastatin; oral
5.6
10.2
43
160
C10AA01
ATC
simvastatin; oral
5.6
10.2
46
185
215
Kela drug reimbursment
Diabetes, non-insulin-treated
5.9
10.0
34
98
E78.9
ICD-10 Finland
Disorder of lipoprotein metabolism, unspecified
+∞
9.6
9
*
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
8.2
9.1
21
35
C10AA07
ATC
rosuvastatin; oral
5.6
8.7
29
79
B01AC04
ATC
clopidogrel; oral
6.9
8.7
23
47
C10AA04
ATC
fluvastatin; oral
11.2
8.6
16
18
C01DA14
ATC
isosorbide mononitrate; oral
6.6
8.4
23
49
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
5.0
7.8
29
88
I20.09
ICD-10 Finland
Unstable angina
13.1
7.7
13
12
E78.29
ICD-10 Finland
Other mixed hyperlipidaemia
+∞
7.4
7
*
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
14.2
7.4
12
10
T90
ICPC
Diabetes non-insulin dependent
4.9
7.4
27
80
A10BJ06
ATC
semaglutide; parenteral
44.6
6.9
8
*
81
HP
Angiography of the heart and coronary arteries
11.8
6.9
12
12
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
4.6
6.7
26
81
XF402
NOMESCO Finland
ECG with work load test
6.1
6.3
17
35
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
3.9
6.3
31
119
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
17.0
6.1
9
6
I20.81
ICD-10 Finland
Other angina pectoris stenosed coronary artery
7.4
6.1
14
23
Z95.1
ICD-10 Finland
Presence of aortocoronary bypass graft
12.8
6.0
10
9
Mortality – FinRegistry
↥Association
Association between endpoint E4_HYPERCHYLO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPERCHYLO | 1.618 [1.15, 2.27] | 0.005 |
| Birth year | 0.996 [0.99, 1.0] | 0.346 |
During the follow-up period (1.1.1998 — 31.12.2019), 56 out of 185 females with E4_HYPERCHYLO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPERCHYLO | 1.441 [1.03, 2.02] | 0.035 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 72 out of 267 males with E4_HYPERCHYLO died.
Mortality risk
Mortality risk for people of age
years, who have E4_HYPERCHYLO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.18% | 0.268% |
| 5 | 0.987% | 1.735% |
| 10 | 2.419% | 4.267% |
| 15 | 4.531% | 7.504% |
| 20 | 8.32% | 12.569% |
Relationships between endpoints
↥Index endpoint: E4_HYPERCHYLO – Hyperchylomicronaemia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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