Unspecified severe protein-energy malnutrition

E4_PROTMALSEVERNAS

protein energy malnutrition: A nutritional deficit that is caused by inadequate protein or calorie intake.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 E43
  • Hospital discharge: ICD-9 262
  • Cause of death: ICD-10 E43
  • Cause of death: ICD-9 262

2 out of 7 registries used, show all original rules.

52

4. Check minimum number of events

None

52

5. Include endpoints

None

52

6. Filter based on genotype QC (FinnGen only)

51

Control definitions (FinnGen only)

Control exclude
E4_MALNUTRITION

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E40-E46
Name in latin
Malnutritio gravis non specificata ex deficientia proteino-energetica

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 626 344 279
Only index persons 505 279 226
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 64.53 67.07 61.20
Only index persons 65.05 66.99 62.65

-FinnGen-

Key figures

All Female Male
Number of individuals 51 25 26
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 59.23 61.63 56.91

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
52
Matched controls
520
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E43
ICD-10 Finland
Unspecified severe protein-energy malnutrition
+∞
67.1
49
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
7.9
7.9
19
35
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
21.3
6.5
9
5

Mortality – FinRegistry

Association

Association between endpoint E4_PROTMALSEVERNAS and mortality.

Females

Parameter HR [95% CI] p-value
E4_PROTMALSEVERNAS 3.346 [1.57, 7.12] 0.002
Birth year 0.993 [0.98, 1.0] 0.107

During the follow-up period (1.1.1998 — 31.12.2019), 68 out of 201 females with E4_PROTMALSEVERNAS died.

Males

Parameter HR [95% CI] p-value
E4_PROTMALSEVERNAS 6.849 [2.06, 22.8] 0.002
Birth year 0.987 [0.98, 1.0] 0.008

During the follow-up period (1.1.1998 — 31.12.2019), 64 out of 160 males with E4_PROTMALSEVERNAS died.

Mortality risk

Mortality risk for people of age

years, who have E4_PROTMALSEVERNAS.

N-year risk Females Males
1 0.29% 1.46%
5 1.942% 8.146%
10 5.103% 19.041%
15 9.243% 33.129%
20 15.862% 49.043%

Relationships between endpoints

Index endpoint: E4_PROTMALSEVERNAS – Unspecified severe protein-energy malnutrition

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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