Unspecified severe protein-energy malnutrition

E4_PROTMALSEVERNAS

protein energy malnutrition: A nutritional deficit that is caused by inadequate protein or calorie intake.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E43 Hospital discharge: ICD-9 — 262 Cause of death: ICD-10 — E43 Cause of death: ICD-9 — 262 2 out of 7 registries used, show all original rules.	58
4. Check minimum number of events None	58
5. Include endpoints None	58
6. Filter based on genotype QC (FinnGen only)	58

Control definitions (FinnGen only)

Control exclude: E4_MALNUTRITION

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: E40-E46
Name in latin: Malnutritio gravis non specificata ex deficientia proteino-energetica

NAME	E4_PROTMALSEVERNAS
CONTROL_EXCLUDE	E4_MALNUTRITION
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E43
HD_ICD_9	262
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E43
COD_ICD_9	262
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Unspecified severe protein-energy malnutrition based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	626	344	279
Only index persons	505	279	226
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	64.53	67.07	61.20
Only index persons	65.05	66.99	62.65

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	58	30	28
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	60.51	61.15	59.82

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
52: Matched controls
520

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

E43

ICD-10 Finland

Unspecified severe protein-energy malnutrition

+∞

67.1

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

7.9

504

Kela drug reimbursment

Conditions requiring daily forced enteral nutrition

21.3

6.5

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

8.49

10.96

1.6

1.3

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

12.11

9.85

1.5

1.0

—

(3023368) Bacteria identified in Blood by Culture

112

4.80

8.12

4.6

3.6

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

232

5.75

7.71

13.9

6.2

1.2

mmol/l

2.01

202

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

221

4.66

6.64

7.8

5.4

9.1

20.7

umol/l

3.32

208

(3003396) Base excess in Arterial blood by calculation

4.75

6.54

16.6

5.8

1.6

1.5

mmol/l

0.02

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

146

3.92

6.18

4.0

79.2

26.8

ng/l

0.88

103

(3013826) Glucose [Moles/volume] in Serum or Plasma

284

5.00

5.74

12.8

4.6

6.9

6.6

mmol/l

0.45

264

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

184

3.79

5.69

5.0

2.5

71.0

74.9

nmol/l

0.37

166

(3032080) INR in Blood by Coagulation assay

169

3.70

5.61

5.3

8.6

1.2

inr

0.47

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

3.96

5.36

4.2

2.3

2.4

mmol/l

0.53

(3019060) Gas panel - Arterial blood

4.99

4.58

4.8

2.6

—

(3007853) Bacteria identified in Skin by Aerobe culture

3.87

4.29

2.2

1.3

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

5.05

4.28

1.6

1.4

—

(3044640) Blood type and Crossmatch panel - Blood

143

3.06

4.18

3.1

2.0

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

172

2.92

3.88

2.6

1.7

85.0

96.6

pmol/l

0.72

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

13.15

3.85

1.5

2.0

—

(3042936) Bacteria identified in Isolate by Culture

3.36

3.69

2.4

1.7

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

4.14

3.68

1.5

1.2

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

10.95

3.58

2.2

1.8

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

10.95

3.58

1.2

2.0

—

(3005895) Myoglobin [Mass/volume] in Serum or Plasma

6.43

3.47

2.5

1.3

500.6

212.7

ug/l

—

(3052851) Hemolysis interference index of Serum or Plasma

7.77

3.47

4.0

4.1

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

3.07

3.33

2.8

1.8

—

(3031040) Bacteria [#/volume] in Urine by Automated count

296

3.02

3.29

7.0

4.0

—

40.5

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

7.06

3.29

2.4

2.0

—

(3020044) Glucose [Moles/volume] in Cerebral spinal fluid

8.19

3.13

3.7

1.1

3.4

3.7

mmol/l

—

(3018418) pH of Serum or Plasma

137

2.63

3.13

5.3

3.6

7.4

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

2.88

3.00

1.6

2.7

2.2

2.4

g/l

0.65

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

5.96

2.96

4.1

5.1

162.9

193.8

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

118

2.57

2.88

1.7

1.5

0.6

0.7

u/ml

—

(36660697) Celiac disease serology panel - Serum

3.43

2.87

1.3

1.2

—

(3022313) Gas panel - Capillary blood

3.43

2.87

15.1

6.0

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

203

2.45

2.79

5.0

3.4

—

(40761535) Cells panel - Urine sediment

3.18

2.74

3.8

3.3

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

171

2.39

2.66

5.2

3.4

—

(3019473) Protein [Mass/volume] in Cerebral spinal fluid

5.94

2.61

3.7

1.1

310.0

560.6

mg/l

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

7.67

2.60

1.4

1.1

—

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

3.35

2.55

17.5

6.6

24.2

24.4

mmol/l

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

101

2.50

2.55

3.3

1.9

—

(3026008) Bacteria identified in Urine by Culture

149

2.35

2.51

5.1

2.9

—

(3020630) Protein [Mass/volume] in Serum or Plasma

3.61

2.43

1.4

1.5

59.3

66.5

g/l

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

104

2.41

2.38

6.1

3.9

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

5.01

2.33

2.8

1.4

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

5.01

2.33

2.8

1.4

—

(3007164) IgA [Mass/volume] in Serum or Plasma

105

2.38

2.32

2.2

1.4

1.8

2.2

g/l

0.48

(3044290) Cell count panel - Cerebral spinal fluid

5.95

2.26

4.2

1.1

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

5.35

2.11

1.6

1.4

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

5.35

2.11

1.6

1.4

—

(3020891) Body temperature

3.40

2.10

5.3

6.0

—

(3036489) Thrombin time

4.33

2.09

6.0

4.7

23.5

20.7

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

2.78

2.07

13.7

9.3

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

280

2.20

2.05

16.4

7.3

3.9

4.2

e9/l

0.27

239

(42529406) Shigella sp [Presence] in Stool by Culture

4.05

1.99

1.5

1.1

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

4.05

1.99

1.5

1.1

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

4.86

1.98

1.8

1.4

—

(3049717) Cytology report of Urine Cyto stain

4.45

1.86

2.0

3.9

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

4.45

1.86

3.0

1.4

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.49

1.82

3.2

1.7

—

(3019225) pH of Specimen

2.93

1.80

5.9

2.3

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

3.59

1.79

10.5

4.8

91.8

87.8

—

(3004588) Protein electrophoresis panel - Serum or Plasma

3.17

1.78

1.1

1.6

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.44

1.75

3.1

1.6

—

(42870588) Differential panel, method unspecified - Blood

159

2.01

1.74

15.7

4.5

—

(3000991) Gas panel - Venous blood

2.39

1.69

32.8

7.3

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

3.80

1.65

1.2

1.3

—

(3034770) Mitochondria Ab [Titer] in Serum

3.80

1.65

1.4

1.6

—

(3020961) Endomysium IgA Ab [Titer] in Serum

2.92

1.64

1.3

1.2

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

2.13

1.62

3.6

2.1

1.7

0.8

mg/l

1.68

(3004119) Hemoglobin [Mass/volume] in Venous blood

2.80

1.57

5.7

6.1

122.7

125.0

g/l

—

(3012544) pH of Venous blood

2.30

1.57

13.3

5.2

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

3.54

1.55

1.6

1.1

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

3.06

1.55

1.8

1.5

—

(3025941) Bacteria identified in Stool by Culture

2.70

1.50

2.3

1.2

—

(3015736) pH of Urine

180

1.81

1.34

5.5

3.8

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

2.49

1.33

1.9

4.8

3.4

8.3

ug/l

—

(3018095) Leukocytes [#/volume] in Urine

172

1.80

1.31

6.2

3.9

414.4

44.1

e6/l

0.95

127

(3000494) Fungus identified in Specimen by Culture

2.21

1.25

1.7

1.3

—

(40758558) Short blood count panel - Blood

131

1.80

1.21

9.8

5.8

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

1.18

0.0

2.1

—

(3003327) Ova and parasites identified in Stool by Light microscopy

2.64

1.17

1.2

1.4

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

2.16

1.17

19.1

4.5

22.8

24.1

mmol/l

—

(3037467) Urinalysis macro (dipstick) panel - Urine

305

1.71

1.09

6.2

4.1

—

(3021589) Normoblasts [#/volume] in Blood

227

1.67

1.07

21.9

9.1

0.0

e9/l

0.00

182

(40768804) Tissue Pathology biopsy report

145

1.70

1.05

2.0

2.1

—

(40760892) CBC W Ordered Manual Differential panel - Blood

111

1.75

1.02

8.6

6.0

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

1.01

0.0

1.8

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.90

1.00

1.3

1.7

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

2.36

0.96

1.5

1.2

—

(36304419) Bacteria [Presence] in Urine

132

1.65

0.91

5.8

3.3

—

(4035726)

1.97

0.84

1.7

1.3

—

(3035350) Ketones [Presence] in Urine by Test strip

237

1.55

0.84

6.4

4.0

0.0

estimate

—

(1761868) Lipid panel - Serum or Plasma

155

0.57

0.80

3.6

3.0

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.76

0.78

1.4

1.6

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.28

0.78

52.8

7.9

—

(3022621) pH of Urine by Test strip

2.01

0.72

6.0

2.0

—

(3029937) Albumin [Presence] in Urine by Test strip

140

1.53

0.70

7.4

4.1

0.0

estimate

—

(3022096) Basophils/100 leukocytes in Blood

228

1.44

0.63

16.9

4.7

0.7

0.6

0.13

212

(3018010) Neutrophils/100 leukocytes in Blood

238

1.44

0.62

16.7

5.0

58.2

54.4

0.68

222

(3019069) Monocytes/100 leukocytes in Blood

238

1.44

0.62

16.6

5.2

8.3

8.6

0.33

222

(1002224) Polysomnography panel

0.00

0.61

0.0

1.1

—

(3009542) Hematocrit [Volume Fraction] of Blood

424

1.57

0.60

34.3

12.9

37.1

40.2

2.23

309

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.60

0.0

1.5

—

(3016879) Cocaine [Presence] in Urine

0.00

0.60

0.0

1.8

—

(3000764) Benzodiazepines [Presence] in Urine

0.00

0.60

0.0

1.8

—

(3027944) Amphetamines [Presence] in Urine

0.00

0.60

0.0

1.8

—

(3027008) Opiates [Presence] in Urine

0.00

0.59

0.0

1.7

—

(3028300) Cannabinoids [Presence] in Urine

0.00

0.59

0.0

1.7

—

(3002030) Lymphocytes/100 leukocytes in Blood

241

1.41

0.57

16.7

5.1

27.9

30.6

0.51

227

(40768797) Stomach Pathology biopsy report

1.60

0.54

1.7

1.2

—

(3006504) Eosinophils/100 leukocytes in Blood

235

1.37

0.50

17.0

4.8

2.4

2.8

0.64

220

(3021601) Nitrite [Presence] in Urine by Test strip

235

1.37

0.50

8.3

5.4

0.0

estimate

—

(3022145) Colonoscopy Study observation

1.56

0.50

1.1

1.3

—

(3003694) ABO and Rh group [Type] in Blood

132

1.41

0.47

1.6

1.4

—

(3013512) EKG study

125

1.39

0.43

4.0

3.4

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.42

0.0

1.2

—

(3011288) Drugs identified in Urine by Screen method

0.00

0.41

0.0

1.9

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.00

0.40

0.0

1.9

—

(3044889) 12 lead EKG panel

301

1.31

0.40

4.2

3.6

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

186

1.29

0.35

7.2

4.2

—

(3009261) Glucose [Presence] in Urine by Test strip

238

1.25

0.30

7.0

4.0

0.0

estimate

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.27

0.23

4.2

3.9

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.21

0.0

1.4

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.21

0.0

1.1

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.21

0.0

1.1

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.5

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.21

0.0

1.3

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.21

0.0

1.3

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

0.21

0.0

2.4

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.21

0.0

1.3

—

(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation

0.00

0.21

0.0

2.1

—

194.0

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.21

0.0

1.3

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.21

0.0

1.3

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.5

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.21

0.0

1.4

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

2.2

—

35.8

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.6

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.21

0.0

1.7

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.20

0.0

5.7

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.23

0.19

61.1

7.7

24.8

24.6

mmol/l

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.21

0.19

1.3

1.5

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.15

0.18

1.4

1.7

—

(3020682) Albumin/Creatinine [Ratio] in Urine

121

1.21

0.17

3.4

4.2

23.8

9.7

mg/mmol

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

122

1.19

0.15

2.5

4.5

12.7

2.0

ug/l

0.57

109

(3041096) Erythrocytes [Presence] in Urine by Automated

138

0.84

0.15

5.7

3.7

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.21

0.14

1.6

1.9

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.05

0.09

1.2

1.6

—

(3026493) Urate [Moles/volume] in Serum or Plasma

111

0.99

0.00

8.5

2.6

326.4

8096.4

umol/l

0.79

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.05

0.00

1.5

1.6

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

302

0.99

0.00

3.3

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.0

2.7

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

2.0

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

2.0

—

(3003245) Complement C1 esterase inhibitor [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

0.4

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

2.2

—

(3001684) Respiratory syncytial virus Ag [Presence] in Specimen

0.00

0.0

1.0

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.0

1.7

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.5

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.0

1.3

—

13.8

—

(40761536) Microorganisms panel - Urine sediment

1.02

0.00

5.8

3.9

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.0

2.4

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

0.0

1.0

—

(3012413) Glucose [Moles/volume] in Serum or Plasma --2 hours post meal

0.00

0.0

1.2

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.2

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.0

1.2

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.0

2.6

—

106.4

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.98

0.00

1.7

2.1

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.2

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.0

3.5

—

8.3

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.4

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.0

3.5

—

1.5

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.0

2.6

—

4.1

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.0

1.3

—

(3011951) Aspergillus fumigatus IgE Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.0

1.4

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.90

0.00

1.7

2.4

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

2.0

—

0.8

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

4.2

—

(4094501)

0.00

0.0

1.3

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.0

2.6

—

Mortality – FinRegistry

↥

Association

Association between endpoint E4_PROTMALSEVERNAS and mortality.

Females

Parameter	HR [95% CI]	p-value
E4_PROTMALSEVERNAS	3.346 [1.57, 7.12]	0.002
Birth year	0.993 [0.98, 1.0]	0.107

During the follow-up period (1.1.1998 — 31.12.2019), 68 out of 201 females with E4_PROTMALSEVERNAS died.

Males

Parameter	HR [95% CI]	p-value
E4_PROTMALSEVERNAS	6.849 [2.06, 22.8]	0.002
Birth year	0.987 [0.98, 1.0]	0.008

During the follow-up period (1.1.1998 — 31.12.2019), 64 out of 160 males with E4_PROTMALSEVERNAS died.

Mortality risk

Mortality risk for people of age

years, who have E4_PROTMALSEVERNAS.

N-year risk	Females	Males
1	0.29%	1.46%
5	1.942%	8.146%
10	5.103%	19.041%
15	9.243%	33.129%
20	15.862%	49.043%

Relationships between endpoints

↥

Index endpoint: E4_PROTMALSEVERNAS – Unspecified severe protein-energy malnutrition

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Unspecified severe protein-energy malnutrition

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints