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Thoracic root disorders

DOID EFO Endpoint Browser PheWeb

G6_THROOT

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G54.3
  • Hospital discharge: ICD-9 — 3533
  • Cause of death: ICD-10 — G54.3
  • Cause of death: ICD-9 — 3533

2 out of 7 registries used, show all original rules.

66

4. Check minimum number of events

None

66

5. Include endpoints

None

66

6. Filter based on genotype QC (FinnGen only)

66

Control definitions (FinnGen only)

Control exclude
G6_NERPLEX

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G54
Name in latin
Morbositates radicum nervorum thoracicorum non alibi classificatae

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 501 279 218
Only index persons 448 254 194
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 52.51 54.30 50.10
Only index persons 51.22 52.91 49.02

-FinnGen-

Key figures

All Female Male
Number of individuals 66 39 27
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 51.00 49.17 53.64

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
60
Matched controls
599
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G54.3
ICD-10 Finland
Thoracic root disorders, not elsewhere classified
+∞
74.2
55
*
N03AX16
ATC
pregabalin; oral
7.1
10.3
30
74
N03AX12
ATC
gabapentin; oral
6.8
8.4
23
50
M79.2
ICD-10 Finland
Neuralgia and neuritis, unspecified
29.4
7.9
10
*
G54.0
ICD-10 Finland
Brachial plexus disorders
90.9
7.6
8
*
N06AA09
ATC
amitriptyline; systemic
8.0
7.5
17
28
R60.0
ICD-10 Finland
Localized oedema
8.7
7.1
15
22
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
19.6
7.0
10
6
N02AX02
ATC
tramadol; systemic, rectal
4.4
6.8
39
178
N06AX21
ATC
duloxetine; oral
6.3
6.6
18
38
M54.5
ICD-10 Finland
Low back pain
4.2
6.3
31
122
M54.9
ICD-10 Finland
Dorsalgia, unspecified
6.6
6.3
16
31
G56.0
ICD-10 Finland
Carpal tunnel syndrome
17.3
6.1
9
6

Mortality – FinRegistry

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Association

Association between endpoint G6_THROOT and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have G6_THROOT.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

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Index endpoint: G6_THROOT – Thoracic root disorders

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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