Acrodermatitis chronica atrophicans

L12_ACRODERMATITIS

acrodermatitis chronica atrophicans: An acrodermatitis characterized by a chronically progressive course, leading to widespread atrophy of the skin. It is a clinical manifestation of Lyme borreliosis.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L90.4
  • Hospital discharge: ICD-9 7018C
  • Hospital discharge: ICD-8 70190
  • Cause of death: ICD-10 L90.4
  • Cause of death: ICD-9 7018C
  • Cause of death: ICD-8 70190

2 out of 7 registries used, show all original rules.

51

4. Check minimum number of events

None

51

5. Include endpoints

None

51

6. Filter based on genotype QC (FinnGen only)

51

Control definitions (FinnGen only)

Control exclude
L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L90
Name in latin
Acrodermatitis chronica atrophicans

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 334 248 84
Only index persons 309 234 75
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.00
Only index persons 0.01 0.01 0.00
Median age at first event (years)
Whole population 62.27 64.11 57.42
Only index persons 62.64 64.30 57.46

-FinnGen-

Key figures

All Female Male
Number of individuals 51 33 18
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 64.19 64.31 63.97

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
11
15
9.07
7.88
1.3
1.2
—
—
—
0
0
18
52
4.80
6.13
1.3
1.3
496.0
805.3
titre
—
5
15
9
12
8.82
4.57
1.1
1.2
1.2
1.1
g/l
—
9
12
9
12
8.82
4.57
1.1
1.2
0.3
0.2
g/l
—
9
12
19
86
2.93
3.13
1.5
1.2
35.5
40.8
iu/ml
—
5
35
29
171
2.61
2.81
3.6
3.4
—
—
—
0
0
25
140
2.54
2.66
7.5
5.2
—
—
—
0
0
5
7
7.75
2.60
1.4
1.4
—
—
—
0
0
7
16
4.89
2.57
1.1
1.3
—
—
—
0
0
43
324
3.08
2.52
5.4
4.5
12.4
11.7
mm/h
0.11
38
289
28
174
2.35
2.29
2.6
1.9
—
—
—
0
0
41
305
2.76
2.20
5.0
4.0
—
—
—
0
0
6
16
4.10
2.00
12.8
7.3
26.5
25.0
mmol/l
—
6
16
7
22
3.52
1.96
2.7
3.3
—
—
—
0
0
28
192
2.02
1.62
8.1
7.9
0.0
0.0
e9/l
0.50
23
156
11
52
2.42
1.58
1.7
1.6
—
—
—
0
0
13
68
2.22
1.50
2.5
3.2
0.8
0.8
mmol/l
0.47
13
63
13
68
2.22
1.50
1.8
2.0
—
—
—
0
0
9
41
2.45
1.46
1.3
1.1
—
—
—
0
0
18
109
2.01
1.44
10.8
8.5
—
—
—
0
0
5
17
3.14
1.39
2.0
1.4
—
—
—
0
0
10
48
2.35
1.38
2.3
2.4
5.3
7.7
umol/l
—
10
43
14
78
2.10
1.38
1.5
1.2
1.4
14.2
u/ml
—
5
31
8
36
2.44
1.31
18.6
8.1
—
—
—
0
0
10
53
2.10
1.10
1.9
3.6
1.8
1.6
%
—
10
48
15
93
1.87
1.09
3.3
4.7
—
—
—
0
0
21
145
1.76
1.09
2.6
2.9
—
—
—
0
0
9
51
1.93
1.01
8.2
4.0
1.1
1.1
mmol/l
—
9
46
0
31
0.00
1.00
0.0
7.5
—
24.4
—
0
31
44
388
1.97
0.93
25.0
15.3
39.0
39.8
%
0.23
33
262
22
164
1.60
0.82
6.0
8.5
1.2
1.3
inr
—
6
48
15
102
1.67
0.79
4.5
3.3
—
—
—
0
0
22
168
1.54
0.72
3.8
3.4
12.8
52.0
e6/l
1.75
15
119
7
42
1.77
0.72
1.1
1.1
—
—
—
0
0
18
132
1.56
0.70
4.0
2.2
75.8
58.1
u/l
0.53
18
121
23
179
1.52
0.69
2.2
2.0
111.0
92.3
pmol/l
—
10
83
5
28
1.87
0.68
8.8
9.0
94.0
93.8
%
—
5
28
18
134
1.53
0.65
3.2
2.6
—
—
—
0
0
8
51
1.67
0.64
1.9
1.3
—
—
—
0
0
29
240
1.48
0.63
8.7
6.3
12.2
11.0
umol/l
0.39
29
225
0
21
0.00
0.61
0.0
3.9
—
1.4
—
0
21
6
38
1.65
0.56
1.3
2.0
—
—
—
0
0
6
39
1.61
0.55
1.0
1.2
—
—
—
0
0
13
93
1.53
0.55
1.1
1.4
6.3
2.6
g/l
—
7
45
5
31
1.68
0.44
8.8
8.2
0.4
0.7
%
—
5
31
5
31
1.68
0.44
8.8
8.3
1.3
1.5
%
—
5
31
5
32
1.62
0.43
1.4
4.1
—
0.3
—
0
6
8
60
1.39
0.43
1.9
2.0
—
—
—
0
0
0
16
0.00
0.42
0.0
1.1
—
—
—
0
0
15
117
1.40
0.41
3.3
3.6
—
—
—
0
0
5
35
1.47
0.40
1.4
4.2
—
0.0
—
0
8
5
35
1.47
0.40
1.4
4.1
—
0.0
—
0
7
11
143
0.71
0.39
4.0
3.2
—
—
—
0
0
6
42
1.48
0.37
9.3
7.5
112.0
121.3
g/l
—
6
42
6
42
1.48
0.37
4.2
1.3
—
—
—
0
0
20
168
1.31
0.34
2.5
4.1
27.7
25.8
ng/l
0.04
11
120
7
55
1.32
0.31
34.0
27.7
—
1.5
—
0
6
5
38
1.35
0.24
1.4
4.0
—
0.6
—
0
9
5
40
1.28
0.23
5.6
4.3
—
—
—
0
0
9
112
0.76
0.23
4.6
5.3
2.1
2.3
ug/l
—
9
96
5
41
1.24
0.22
20.8
3.6
—
—
—
0
0
5
42
1.21
0.22
1.2
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
3.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
3.7
—
86.1
—
0
10
0
10
0.00
0.21
0.0
6.3
—
1.0
—
0
10
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
204.7
—
0
7
6
48
1.28
0.21
9.2
7.0
0.5
1.7
mmol/l
—
6
38
6
48
1.28
0.21
9.3
7.0
11.9
11.4
kpa
—
6
48
6
48
1.28
0.21
9.5
7.0
5.3
5.0
kpa
—
6
48
0
13
0.00
0.21
0.0
7.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.7
—
132.4
—
0
8
7
60
1.19
0.19
1.6
1.5
—
—
—
0
0
5
46
1.10
0.10
3.6
4.8
—
—
—
0
0
44
431
1.15
0.08
4.7
4.6
4.8
4.6
mmol/l
0.52
38
400
43
418
1.18
0.07
6.0
6.3
38.1
40.0
mmol/mol
1.10
37
390
43
418
1.18
0.07
4.3
4.1
1.1
1.3
mmol/l
0.91
37
380
11
120
0.89
0.05
1.5
1.5
—
—
—
0
0
14
130
1.11
0.05
2.6
2.0
—
—
—
0
0
11
111
0.99
0.00
3.8
3.9
—
—
—
0
0
14
139
1.01
0.00
3.6
4.2
—
—
—
0
0
30
303
0.98
0.00
3.8
3.9
—
—
—
0
0
0
7
0.00
0.00
0.0
6.0
—
10.3
—
0
7
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
7
71
0.98
0.00
3.7
2.1
15.2
14.1
umol/l
—
7
63
6
65
0.91
0.00
4.2
2.1
2.5
2.4
g/l
—
6
58
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
6.0
—
103.0
—
0
7
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
3.6
—
0
5
0
7
0.00
0.00
0.0
3.1
—
—
—
0
0
0
7
0.00
0.00
0.0
3.1
—
3.9
—
0
7
0
5
0.00
0.00
0.0
1.0
—
12.2
—
0
5
0
5
0.00
0.00
0.0
11.0
—
—
—
0
0
0
7
0.00
0.00
0.0
3.1
—
108.4
—
0
7
43
429
1.01
0.00
4.8
4.7
1.6
1.5
mmol/l
0.49
37
393
6
63
0.95
0.00
1.2
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
44
440
1.00
0.00
5.1
5.3
2.9
2.7
mmol/l
0.66
38
407
0
7
0.00
0.00
0.0
4.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint L12_ACRODERMATITIS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_ACRODERMATITIS.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: L12_ACRODERMATITIS – Acrodermatitis chronica atrophicans

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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