No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
53 |
4. Check minimum number of eventsNone |
53 |
5. Include endpointsNone |
53 |
6. Filter based on genotype QC (FinnGen only) |
50 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Similar endpoints
↥List of similar endpoints to
Aortic stenosis
based on the number of shared cases.
Similar with more cases:
- Aortic stenosis
- Congenital malformations of great arteries
- Left ventricular outflow tract obstruction, narrow definition
- Left ventricular outflow tract obstruction (LVOTO), broad definition
- Congenital malformations of heart and great arteries
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded (different definition than used in FinnGen).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 50 | 24 | 26 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 28.01 | 22.88 | 32.75 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 53
- Matched controls
- 530
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q25.3
ICD-10 Finland
Stenosis of aorta
+∞
75.9
53
*
Q25.1
ICD-10 Finland
Coarctation of aorta
311.9
21.2
20
*
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
13.3
19.8
38
85
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
29.1
19.5
27
18
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
13.3
19.1
24
31
ZXE20
NOMESCO Finland
More than three and less than five hours
12.5
18.2
24
33
I35.0
ICD-10 Finland
Aortic (valve) stenosis
36.3
17.4
22
10
TPH07
NOMESCO Finland
Cathetrisation of artery
10.9
16.8
25
40
C03CA01
ATC
furosemide; systemic
9.0
14.8
31
72
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
23.9
14.7
21
14
XF400
NOMESCO Finland
ECG with 12 standard connections
8.3
13.4
26
55
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
7.6
12.3
27
64
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
7.7
12.3
25
55
Q23.0
ICD-10 Finland
Congenital stenosis of aortic valve
135.8
10.8
11
*
WX408
NOMESCO Finland
General anesthesy, balanced
5.9
9.6
29
90
FM2CE, ,
NOMESCO Finland
18.4
9.3
14
10
B01AA03
ATC
warfarin; systemic
9.4
9.2
20
32
I35.2
ICD-10 Finland
Aortic (valve) stenosis with insufficiency
33.9
8.9
11
*
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
106.3
8.7
9
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.6
8.4
36
146
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
13.1
8.1
14
14
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
15.2
8.1
13
11
Q23.11
ICD-10 Finland
Bicuspid aortic valve
53.1
8.0
9
*
ZXD10
NOMESCO Finland
Scheduled procedure
5.1
7.9
33
130
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
5.3
7.7
21
58
Q21.09
ICD-10 Finland
Ventricular septal defect NOS
92.5
7.6
8
*
Q24.4
ICD-10 Finland
Congenital subaortic stenosis
+∞
7.5
7
*
TFC99
NOMESCO Finland
Catheterisation of heart with other procedure
46.1
7.0
8
*
61
HP
Catheterization and pressure measurement of the left side of the heart
79.0
6.6
7
*
XF600
NOMESCO Finland
Bloodpressure measurement
7.2
6.5
16
30
Z98.8
ICD-10 Finland
Other specified postsurgical states
30.7
6.4
8
*
31
HP
Congenital heart failure surgery
+∞
6.4
6
*
ZXE10
NOMESCO Finland
More than one and less than three hours
4.2
6.3
28
111
WX892
NOMESCO Finland
Monitored bed care
7.0
6.1
15
28
TPH04
NOMESCO Finland
Cathetrisation of vein
4.5
6.1
20
63
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
36
96
9.57
15.22
11.1
5.2
2571.16
1602.64
ng/l
0.54
36
79
41
141
9.43
13.02
46.8
11.2
2.16
1.26
inr
—
7
38
26
70
6.33
10.14
5.3
5.8
32.38
30.54
s
0.81
26
70
19
39
7.04
9.71
8.9
8.7
78.63
83.79
%
0.39
19
39
27
93
4.88
7.56
4.1
4.1
—
—
—
0
0
16
31
6.92
6.36
4.1
8.9
190.88
175.61
%
0.29
16
31
23
84
4.07
5.70
4.3
4.5
1.73
2.19
mg/l
0.18
15
68
42
253
4.18
4.63
19.1
15.1
6.35
6.26
mmol/l
0.11
42
236
21
82
3.59
4.59
2.6
2.1
—
—
—
0
0
14
36
4.90
4.42
9.1
21.2
0.83
0.61
%
1.95
14
36
14
37
4.76
4.31
9.1
20.7
1.02
1.15
%
0.39
14
37
18
66
3.62
4.28
2.6
2.1
—
—
—
0
0
7
7
11.27
4.14
4.6
2.9
1096.29
95.39
ug/l
—
7
7
17
63
3.50
3.95
2.6
2.0
—
—
—
0
0
17
68
3.21
3.47
12.5
19.3
105.88
104.00
mmol/l
0.80
17
68
23
112
2.86
3.32
5.0
4.2
26.52
44.30
ng/l
0.45
16
77
29
172
2.52
2.71
5.0
3.8
—
—
—
0
0
6
11
5.99
2.62
1.0
1.7
—
—
—
0
0
5
8
6.75
2.42
1.8
4.9
100.80
106.38
%
—
5
8
12
52
2.69
2.05
4.5
3.3
19.92
23.27
%
0.55
12
45
5
11
4.89
1.98
2.0
1.4
—
—
—
0
0
7
24
3.20
1.79
1.6
2.4
—
—
—
0
0
7
24
3.20
1.79
1.6
2.4
—
—
—
0
0
19
110
2.13
1.73
21.3
21.7
25.42
24.63
mmol/l
0.81
19
110
5
17
3.13
1.39
1.0
2.2
—
—
—
0
0
48
419
2.54
1.33
15.4
10.5
24.81
25.00
u/l
0.03
48
402
5
18
2.95
1.31
10.0
8.9
—
634.57
—
0
7
12
65
2.09
1.26
4.5
3.0
11.79
12.94
umol/l
0.36
12
59
8
38
2.30
1.25
2.4
1.6
—
—
—
0
0
35
278
1.76
1.09
10.9
11.3
4.42
3.74
e9/l
0.93
29
226
5
22
2.40
1.05
1.8
2.2
—
—
—
0
0
5
22
2.40
1.05
1.8
2.2
—
—
—
0
0
24
175
1.68
1.00
7.3
4.4
—
—
—
0
0
7
37
2.02
0.98
2.0
1.8
—
—
—
0
0
17
113
1.74
0.98
2.9
1.8
85.29
87.54
pmol/l
—
7
59
33
263
1.68
0.97
29.4
12.4
78.66
86.85
ml/min/173m2
1.13
26
205
46
407
1.98
0.93
39.3
19.8
14.11
14.59
%
0.82
46
398
5
24
2.19
0.77
1.8
2.4
—
—
—
0
0
5
24
2.19
0.77
1.8
2.4
—
—
—
0
0
5
28
1.87
0.68
1.6
1.2
—
—
—
0
0
14
99
1.56
0.62
22.2
12.3
1.22
0.86
mmol/l
0.23
14
76
18
137
1.48
0.57
6.7
3.6
—
—
—
0
0
5
31
1.67
0.44
1.2
1.2
—
—
—
0
0
34
301
1.36
0.43
5.4
4.0
1.38
1.42
mmol/l
0.26
34
278
0
16
0.00
0.42
0.0
1.6
—
—
—
0
0
5
34
1.52
0.41
14.2
9.9
—
—
—
0
0
34
306
1.31
0.35
6.0
4.4
2.49
2.68
mmol/l
0.61
34
282
14
111
1.36
0.34
4.7
3.7
51.07
55.50
u/l
0.31
14
106
8
66
1.25
0.28
2.8
2.8
476.63
341.50
nmol/l
—
8
58
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
5.6
—
42.13
—
0
10
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
11
119
0.90
0.04
2.0
2.1
—
—
—
0
0
33
335
0.96
0.00
4.0
3.7
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
2.0
—
—
—
0
0
0
9
0.00
0.00
0.0
2.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
110.33
—
0
6
0
6
0.00
-0.00
0.0
5.2
—
26.90
—
0
6
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
6.42
—
0
6
Mortality – FinRegistry
↥This endpoint is excluded (different definition than used in FinnGen).
Relationships between endpoints
↥Index endpoint: Q17_AORTIC_STENOSIS – Aortic stenosis
GWS hits: -
This endpoint is excluded (different definition than used in FinnGen).