This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Aortic stenosis
Q17_AORTIC_STENOSIS_WIDE
No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
78 |
4. Check minimum number of eventsNone |
78 |
5. Include endpointsNone |
78 |
6. Filter based on genotype QC (FinnGen only) |
73 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF13
Similar endpoints
↥List of similar endpoints to
Aortic stenosis
based on the number of shared cases.
Similar with more cases:
- Vertebral, anorectal, cardiavascular, thracheoesophagial, renal and limb anomaly
- Congenital malformations, deformations and chromosomal abnormalities
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded (different definition than used in FinnGen).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 73 | 34 | 39 |
| Unadjusted period prevalence (%) | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | 54.78 | 54.58 | 54.95 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 78
- Matched controls
- 780
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q25.3
ICD-10 Finland
Stenosis of aorta
+∞
112.2
78
*
I35.0
ICD-10 Finland
Aortic (valve) stenosis
25.2
43.0
37
27
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
16.5
30.0
31
30
Q25.1
ICD-10 Finland
Coarctation of aorta
340.3
25.2
24
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
11.4
23.6
32
45
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
8.9
21.2
51
136
TPH07
NOMESCO Finland
Cathetrisation of artery
7.4
16.2
32
67
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
6.8
16.1
40
105
ZXE20
NOMESCO Finland
More than three and less than five hours
7.7
15.8
29
56
XF400
NOMESCO Finland
ECG with 12 standard connections
6.7
15.6
36
88
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
15.0
13.7
23
21
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
5.6
12.8
36
103
WX892
NOMESCO Finland
Monitored bed care
7.3
12.5
22
40
B01AA03
ATC
warfarin; systemic
5.5
11.9
32
87
Q23.0
ICD-10 Finland
Congenital stenosis of aortic valve
139.8
11.8
12
*
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
42.0
11.7
14
*
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
5.2
11.5
36
111
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
6.3
10.8
22
46
I35.2
ICD-10 Finland
Aortic (valve) stenosis with insufficiency
22.8
10.8
15
8
C03CA01
ATC
furosemide; systemic
4.5
9.9
43
168
FMD10
NOMESCO Finland
Replacement of aortic valve using biological prosthesis
113.2
9.6
10
*
ZXD10
NOMESCO Finland
Scheduled procedure
4.5
9.6
49
214
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.4
9.0
54
262
Q23.11
ICD-10 Finland
Bicuspid aortic valve
56.6
8.9
10
*
FM2CE, ,
NOMESCO Finland
12.9
8.7
15
14
WX408
NOMESCO Finland
General anesthesy, balanced
4.1
8.6
39
154
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
8.7
8.4
18
26
TPH04
NOMESCO Finland
Cathetrisation of vein
4.0
7.6
30
106
Q21.09
ICD-10 Finland
Ventricular septal defect NOS
88.1
7.6
8
*
Z2221
NOMESCO Finland
Medical doctor
3.7
7.4
36
146
Q24.4
ICD-10 Finland
Congenital subaortic stenosis
+∞
7.4
7
*
Q23.10
ICD-10 Finland
Congenital insufficiency of aortic valve
+∞
7.4
7
*
Z98.8
ICD-10 Finland
Other specified postsurgical states
25.1
6.8
9
*
TFC99
NOMESCO Finland
Catheterisation of heart with other procedure
25.1
6.8
9
*
Q25.40
ICD-10 Finland
Aortic hypoplasia
75.8
6.5
7
*
XF600
NOMESCO Finland
Bloodpressure measurement
4.6
6.5
18
48
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
7.2
6.4
15
25
K83
ICPC
Heart valve disease NOS
+∞
6.3
6
*
AB2
HP
AVR bio, stent
+∞
6.3
6
*
31
HP
Congenital heart failure surgery
+∞
6.3
6
*
61
HP
Catheterization and pressure measurement of the left side of the heart
16.7
6.1
9
6
PD5BD
NOMESCO Finland
Extensive CT of aorta
16.7
6.1
9
6
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
63
255
8.65
15.83
44.5
16.3
1.96
1.31
inr
1.84
12
78
42
138
5.43
12.64
3.4
3.5
—
—
—
0
0
46
191
4.43
9.70
9.6
5.0
2763.67
1673.89
ng/l
0.79
46
157
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
16
19
10.28
8.31
14.1
9.4
0.40
0.34
u/ml
—
9
10
27
88
4.16
7.65
10.4
11.7
8.04
7.27
mmol/l
0.26
27
83
17
40
5.16
7.17
7.8
19.3
0.73
0.62
%
0.59
17
40
17
42
4.90
6.76
7.8
18.6
1.04
1.11
%
0.25
17
42
54
299
3.62
6.62
12.4
8.9
28.58
24.64
umol/l
0.23
48
285
22
72
3.86
6.07
2.5
6.7
289.18
316.29
u/l
0.22
22
66
48
259
3.22
5.92
4.2
3.5
—
—
—
0
0
26
100
3.40
5.61
10.2
16.5
104.69
103.70
mmol/l
0.48
26
100
13
22
6.86
5.50
7.5
26.7
63.48
67.93
%
0.34
13
22
29
124
3.13
5.22
4.0
3.8
1.52
1.97
mg/l
0.25
20
100
53
341
2.73
4.15
15.1
14.5
1.21
1.22
mmol/l
0.19
46
296
27
134
2.55
3.51
2.5
2.1
—
—
—
0
0
21
101
2.48
2.86
2.6
2.1
—
—
—
0
0
56
409
2.31
2.79
9.8
10.9
4.50
4.12
e9/l
0.57
47
339
20
97
2.43
2.67
2.6
2.0
—
—
—
0
0
34
209
2.11
2.58
5.1
4.5
30.56
53.60
ng/l
0.71
22
152
6
12
5.31
2.45
2.0
1.3
—
—
—
0
0
29
173
2.08
2.34
2.9
2.7
2.87
2.92
mg/l
0.03
23
149
23
127
2.15
2.25
18.3
20.5
25.79
24.69
mmol/l
1.01
23
127
5
10
5.26
2.10
1.8
4.3
100.80
101.60
%
—
5
10
5
10
5.26
2.10
1.2
5.9
—
—
—
0
0
65
532
2.33
2.08
4.7
4.4
2.07
2.12
mu/l
0.11
60
478
33
215
1.93
2.04
3.1
2.0
87.71
91.18
pmol/l
0.15
14
106
71
618
2.66
1.97
33.9
16.7
27.41
23.94
mg/l
0.44
60
489
57
449
2.00
1.95
10.0
7.2
103.00
101.51
u/l
0.03
52
419
6
17
3.73
1.87
1.0
1.5
—
—
—
0
0
5
12
4.37
1.85
1.4
4.7
0.00
0.00
g/l
—
5
12
5
12
4.37
1.85
1.4
4.7
0.00
0.00
g/l
—
5
12
12
54
2.44
1.85
2.2
1.6
—
—
—
0
0
38
269
1.80
1.76
6.1
4.3
—
—
—
0
0
5
13
4.03
1.74
1.4
4.4
0.00
0.00
g/l
—
5
13
11
54
2.21
1.40
1.7
1.8
—
—
—
0
0
54
442
1.72
1.36
31.0
15.7
76.40
80.43
ml/min/173m2
0.63
43
350
5
18
2.89
1.30
1.4
3.4
—
—
—
0
0
5
18
2.89
1.30
2.4
1.6
—
—
—
0
0
22
144
1.74
1.27
4.6
4.3
1.04
0.62
e6/l
0.56
14
84
21
139
1.70
1.16
4.6
4.5
7.77
1.42
e6/l
0.90
13
81
18
115
1.73
1.12
18.1
12.1
4.97
5.01
kpa
0.12
18
110
7
33
2.23
1.08
1.6
2.1
—
—
—
0
0
7
33
2.23
1.08
1.6
2.1
—
—
—
0
0
5
22
2.36
1.05
1.0
2.0
—
—
—
0
0
5
22
2.36
1.05
10.0
9.5
—
580.75
—
0
8
15
96
1.70
0.93
18.9
12.0
9.57
9.22
kpa
0.36
15
91
6
29
2.16
0.91
1.2
1.2
—
—
—
0
0
6
30
2.08
0.89
1.2
1.2
—
—
—
0
0
5
25
2.07
0.74
2.6
1.6
—
—
—
0
0
5
25
2.07
0.74
2.6
1.6
—
—
—
0
0
5
27
1.91
0.69
1.8
2.0
—
—
—
0
0
5
27
1.91
0.69
1.8
2.0
—
—
—
0
0
7
44
1.65
0.67
1.1
1.3
—
—
—
0
0
16
115
1.49
0.63
20.1
12.0
1.38
1.14
mmol/l
0.16
16
87
5
30
1.71
0.62
1.8
2.2
—
—
—
0
0
5
30
1.71
0.62
1.8
2.2
—
—
—
0
0
15
109
1.47
0.56
3.6
3.1
0.74
0.78
ug/l
—
10
74
7
45
1.61
0.50
1.9
1.2
—
—
—
0
0
49
440
1.31
0.48
4.8
4.4
15.09
13.01
mm/h
0.39
44
402
0
16
0.00
0.41
0.0
1.6
—
—
—
0
0
19
153
1.32
0.40
4.1
3.7
5.94
10.18
mg/mmol
0.55
11
98
20
166
1.28
0.34
6.9
4.4
0.00
0.00
estimate
—
7
54
47
435
1.20
0.28
3.8
3.4
—
—
—
0
0
35
317
1.19
0.26
6.0
5.8
0.00
0.00
estimate
—
8
57
17
143
1.24
0.26
5.1
4.8
20.71
21.47
%
—
8
72
35
320
1.17
0.23
5.1
4.2
0.00
0.00
estimate
—
8
57
35
320
1.17
0.23
5.2
4.2
0.00
0.00
estimate
—
8
54
0
11
0.00
0.21
0.0
2.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.8
—
—
—
0
0
0
13
0.00
0.21
0.0
4.5
—
32.87
—
0
13
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
5
45
1.12
0.10
1.6
1.3
—
—
—
0
0
6
55
1.10
0.09
1.2
1.1
—
—
—
0
0
6
55
1.10
0.09
1.8
2.2
—
—
—
0
0
7
66
1.07
0.08
7.1
3.3
—
—
—
0
0
9
83
1.10
0.07
2.6
2.6
487.22
372.24
nmol/l
—
9
74
13
141
0.91
0.06
2.2
2.1
—
—
—
0
0
23
219
1.07
0.05
6.1
4.3
—
—
—
0
0
18
176
1.03
0.00
4.3
3.2
52.11
54.67
u/l
0.19
18
165
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
4.1
—
3223.21
—
0
7
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
4.6
—
26.34
—
0
7
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
14.17
—
0
6
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.4
—
—
—
0
0
5
59
0.84
-0.00
14.2
12.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
5.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
6.67
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
89.20
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
110.33
—
0
6
0
6
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
87.00
—
0
6
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
5.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
50
1.00
-0.00
1.8
2.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
Mortality – FinRegistry
↥This endpoint is excluded (different definition than used in FinnGen).
Relationships between endpoints
↥Index endpoint: Q17_AORTIC_STENOSIS_WIDE – Aortic stenosis
GWS hits: -
This endpoint is excluded (different definition than used in FinnGen).