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Left ventricular outflow tract obstruction, narrow definition

Endpoint Browser PheWeb

Q17_LVOTO_NARROW

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — Q23, Q24.4, Q25.1, Q25.20, Q25.3, Q25.40
  • Hospital discharge: ICD-9 — 7463A|7464A|7463D|7465A|7466A|7467A|7468X|7463X|7471A|7472B|7471B
  • Hospital discharge: excluded ICD-10 — Q90|Q91|Q92|Q93|Q96|Q8780|Q8781|Q8782|Q8783|Q8784|Q8786|Q8788|Q85|Q796|Q874|Q875
  • Hospital discharge: excluded ICD-9 — 758|7595|75683
  • Cause of death: ICD-10 — Q23, Q24.4, Q25.1, Q25.20, Q25.3, Q25.40
  • Cause of death: ICD-9 — 7463A|7464A|7463D|7465A|7466A|7467A|7468X|7463X|7471A|7472B|7471B
  • Cause of death: excluded ICD-10 — Q90|Q91|Q92|Q93|Q96|Q8780|Q8781|Q8782|Q8783|Q8784|Q8786|Q8788|Q85|Q796|Q874|Q875
  • Cause of death: excluded ICD-9 — 758|7595|75683

2 out of 7 registries used, show all original rules.

1849

4. Check minimum number of events

None

1849

5. Include endpoints

None

1849

6. Filter based on genotype QC (FinnGen only)

1849

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF7

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 14391 5274 9068
Only index persons 11312 4077 7235
Unadjusted period prevalence (%)
Whole population 0.22 0.15 0.25
Only index persons 0.23 0.15 0.28
Median age at first event (years)
Whole population 18.56 15.60 20.08
Only index persons 29.81 26.79 31.51

-FinnGen-

Key figures

All Female Male
Number of individuals 1849 666 1183
Unadjusted period prevalence (%) 0.42 0.23 0.52
Median age at first event (years) 47.45 41.65 50.72

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1631
Matched controls
16295
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q23.11
ICD-10 Finland
Bicuspid aortic valve
16384.0
323.0
1161
*
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
10.8
323.0
959
1904
Q25.1
ICD-10 Finland
Coarctation of aorta
+∞
323.0
313
*
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
17.7
323.0
567
477
B01AA03
ATC
warfarin; systemic
10.8
323.0
763
1231
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
27.0
323.0
515
274
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
10.3
323.0
772
1306
I71.2
ICD-10 Finland
Thoracic aortic aneurysm, without mention of rupture
36.7
323.0
441
163
I35.0
ICD-10 Finland
Aortic (valve) stenosis
33.6
323.0
570
256
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
40.2
323.0
633
253
I35.2
ICD-10 Finland
Aortic (valve) stenosis with insufficiency
55.0
318.9
379
89
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
50.2
313.9
380
98
FMD00
NOMESCO Finland
Replacement of aortic valve using mechanical prosthesis
81.4
228.0
255
37
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
5.9
189.6
650
1637
WX872
NOMESCO Finland
Intensive care
11.6
167.0
330
348
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
5.6
157.9
544
1327
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
7.0
133.8
365
643
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.6
130.6
930
4350
Q23.0
ICD-10 Finland
Congenital stenosis of aortic valve
+∞
129.9
123
*
FMD10
NOMESCO Finland
Replacement of aortic valve using biological prosthesis
33.9
127.6
168
55
C07AB07
ATC
bisoprolol; oral
3.6
126.9
888
4061
I71.9
ICD-10 Finland
Aortic aneurysm of unspecified site, without mention of rupture
32.1
125.9
168
58
Q23.10
ICD-10 Finland
Congenital insufficiency of aortic valve
+∞
121.3
115
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
7.2
120.7
319
531
K83
ICPC
Heart valve disease NOS
36.8
117.0
151
45
201
Kela drug reimbursment
Chronic cardiac insufficiency
10.5
111.2
228
248
PD5BD
NOMESCO Finland
Extensive CT of aorta
22.0
103.6
154
77
FCA60
NOMESCO Finland
Resection of aortic root and ascending aorta with reimplantation of coronary arteries and use of composite graft with mechanical valve prosthesis
116.6
101.3
109
10
74719
ICD-8 Finland
Other congenital anomalies of circulatory system, Coarctation of aorta
960.9
93.8
91
*
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
19.3
91.6
142
80
FCA50
NOMESCO Finland
Resection and reconstruction of ascending aorta using tube graft
77.4
90.4
102
14
ZXE20
NOMESCO Finland
More than three and less than five hours
4.1
86.0
391
1169
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
7.7
83.5
206
301
FM1DG
NOMESCO Finland
Very extensive MRI examination of heart with high intesity magnet
18.0
80.0
127
76
XF402
NOMESCO Finland
ECG with work load test
4.6
78.7
305
776
XF404
NOMESCO Finland
Ambulatory ECG
4.8
78.4
293
718
7471A
ICD-9 Finland
Other congenital anomalies of circulatory system, Coarctation of aorta[COARCTATIO AORTAE]
+∞
76.6
73
*
PD5CG
NOMESCO Finland
Extensive MRI examination of thoracal and abdominal aortta with high intensity magnet
58.0
74.8
88
16
C03CA01
ATC
furosemide; systemic
3.2
74.2
471
1815
B01AB05
ATC
enoxaparin; parenteral
2.9
71.3
555
2447
PC1BD
NOMESCO Finland
Extensive CT of thoracic aorta
48.4
68.4
83
18
TPH07
NOMESCO Finland
Cathetrisation of artery
4.2
68.0
289
796
XF400
NOMESCO Finland
ECG with 12 standard connections
3.2
67.3
418
1568
I48
ICD-10 Finland
Atrial fibrillation and flutter
3.3
65.6
393
1433
WX408
NOMESCO Finland
General anesthesy, balanced
2.7
64.6
604
2942
TFC99
NOMESCO Finland
Catheterisation of heart with other procedure
39.8
60.3
76
20
31
HP
Congenital heart failure surgery
160.9
59.3
62
*
XF640
NOMESCO Finland
NA
10.4
59.1
119
122
ZXE30
NOMESCO Finland
More than five and less than seven hours
5.1
56.5
191
413
61
HP
Catheterization and pressure measurement of the left side of the heart
15.8
56.2
93
62
AB1
HP
AVR mechanical
42.3
55.5
69
17
Q21.00
ICD-10 Finland
Multiple ventricular septal defect
30.5
54.5
73
25
FM2CE
NOMESCO Finland
NA
8.7
54.4
121
148
Q21.09
ICD-10 Finland
Ventricular septal defect NOS
29.2
51.7
70
25
XFE00
NOMESCO Finland
Epicardial ultrasonography
8.6
51.6
116
144
TFP20
NOMESCO Finland
Cardiodefibrillation
4.6
51.6
194
468
C03DA01
ATC
spironolactone; oral
3.9
50.9
230
659
Q23.4
ICD-10 Finland
Hypoplastic left heart syndrome
+∞
50.2
48
*
Q23.3
ICD-10 Finland
Congenital mitral insufficiency
+∞
49.2
47
*
Q24.4
ICD-10 Finland
Congenital subaortic stenosis
+∞
48.1
46
*
ZXD10
NOMESCO Finland
Scheduled procedure
2.2
47.8
684
3989
Q25.3
ICD-10 Finland
Stenosis of aorta
480.9
47.6
47
*
Q21.08
ICD-10 Finland
Other specifed ventricular septal defect
16.0
47.5
78
51
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
14.1
46.9
81
60
GAE10
NOMESCO Finland
Closure of previous incision of chest wall
33.3
46.6
61
19
PD5BG
NOMESCO Finland
MRI examination of thoracal and abdominal aortta with high intensity magnet
164.6
46.0
48
*
XF600
NOMESCO Finland
Bloodpressure measurement
3.8
45.5
207
594
K84
ICPC
Heart disease other
8.3
44.2
101
129
Q25.40
ICD-10 Finland
Aortic hypoplasia
+∞
42.9
41
*
TFP00
NOMESCO Finland
Temporary use of transvenous or epicardial pacemaker
18.0
42.2
66
38
C01AA05
ATC
digoxin; systemic
4.6
42.0
154
360
R4110
NOMESCO Finland
Physiotherapy
2.3
41.9
509
2711
Q21.10
ICD-10 Finland
Persistent ostium secundum
12.6
41.9
76
63
AN1
HP
Coronary angiography
3.3
40.9
226
755
FM1CG
NOMESCO Finland
Extensive examination of hear with high intensity magnet
19.7
40.3
61
32
Z2221
NOMESCO Finland
Medical doctor
2.2
40.3
516
2807
62
HP
Catheterization and pressure measurement of the right side of the heart
39.6
39.8
50
13
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
4.7
39.4
142
326
AJ1
HP
Reconstruction of the aortic base, eg composite graft, incl. valve saving operation
75.4
39.1
44
6
XF622
NOMESCO Finland
Measurement of minute volume of heart
26.5
39.1
54
21
PD5DG
NOMESCO Finland
Very extensive MRI examination of thoracal and abdominal aortta with high intensity magnet
73.3
38.1
43
6
7463A
ICD-9 Finland
Other congenital anomalies of heart, Congenital stenosis of aortic valve[STENOSIS VALVULAE AORTAE CONGENITA]
+∞
37.6
36
*
I44.2
ICD-10 Finland
Atrioventricular block, complete
9.0
37.5
81
94
WX402
NOMESCO Finland
General anaesthesia
2.4
37.0
370
1774
I35.9
ICD-10 Finland
Aortic valve disorder, unspecified
32.9
36.7
48
15
I50.9
ICD-10 Finland
Heart failure, unspecified
3.3
36.0
196
645
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
5.3
36.0
114
227
C01BD01
ATC
amiodarone; systemic
6.8
36.0
93
143
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
6.0
35.9
103
182
Q25.0
ICD-10 Finland
Patent ductus arteriosus
16.2
35.7
58
37
FC1AC
NOMESCO Finland
Angiography of thoracal aortta
29.0
35.6
48
17
J01CA04
ATC
amoxicillin; systemic
2.2
34.9
1366
11370
Q20.3
ICD-10 Finland
Discordant ventriculoarterial connection
52.5
34.5
41
8
FDA00
NOMESCO Finland
Aortoplasty and aorto-pulmonary shunt for HLHS
+∞
33.4
32
*
FXA10
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia at concurrent surgical procedure
57.0
33.3
39
7
ZXE40
NOMESCO Finland
More than seven and less than nine hours
5.9
32.5
93
164
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
3.3
32.5
173
559
WX892
NOMESCO Finland
Monitored bed care
3.2
32.1
180
604
FCA70
NOMESCO Finland
Resection of aortic root and ascending aorta with reimplantation of coronary arteries and use of biological valve prosthesis and tube graft
48.5
31.6
38
8
ZXD05
NOMESCO Finland
Urgent procedure
2.0
31.0
523
3122
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
7.3
30.9
76
109
I33.0
ICD-10 Finland
Acute and subacute infective endocarditis
18.6
30.6
47
26
AB2
HP
AVR bio, stent
28.0
30.3
41
15
O99.4
ICD-10 Finland
Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium
29.2
29.9
40
14
Z95.8
ICD-10 Finland
Presence of other cardiac and vascular implants and grafts
29.2
29.9
40
14
WZC30
NOMESCO Finland
Teaching
2.5
29.6
264
1178
WW502
NOMESCO Finland
Autotransfusion
21.0
29.2
43
21
C09AA05
ATC
ramipril; oral
2.2
28.9
355
1851
FN1BB
NOMESCO Finland
Contrast angiography of heart and/or coronary arteries after bypass surgery
12.5
28.3
51
42
ZXE10
NOMESCO Finland
More than one and less than three hours
1.9
27.6
576
3685
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.8
27.5
703
4812
I97.0
ICD-10 Finland
Postcardiotomy syndrome
20.5
27.0
40
20
C07AB02
ATC
metoprolol; systemic
2.3
26.7
283
1370
I35.8
ICD-10 Finland
Other aortic valve disorders
34.7
26.5
34
10
K78
ICPC
Atrial fibrillation/flutter
3.5
26.4
132
405
AJ2
HP
Reconstruction of the ascending aorta
52.6
26.3
31
6
FN1CD
NOMESCO Finland
Very extensive CT of coronary arteries
14.5
26.2
44
31
FPE20
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with atrial and ventricular electrodes
5.1
26.1
84
171
PD5AD
NOMESCO Finland
CT of aorta
8.5
25.9
57
69
K99
ICPC
Cardiovascular disease other
6.2
25.9
71
119
74673
ICD-8 Finland
Congenital anomalies of heart, Stenosis valvulae aortae
264.4
25.8
26
*
ZXE00
NOMESCO Finland
One hour or less
1.8
25.7
652
4419
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
4.8
25.5
87
189
Z95.3
ICD-10 Finland
Presence of xenogenic heart valve
25.5
25.3
35
14
5513
FHL
Coarctation resection, plastic or bypass
+∞
25.1
24
*
FC1BC
NOMESCO Finland
Extensive angiography of thoracal aortta
39.5
24.9
31
8
21
HP
Aortic Valve Replacement (AVR)
43.5
24.6
30
7
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.9
24.3
471
2907
FCA75
NOMESCO Finland
Valve-sparing repair of aortic root (David, Yacoub)
49.1
24.3
29
6
5253
FHL
Cardiac lung machine
14.0
24.1
41
30
5273
FHL
Repair with flap prosthesis or graft
42.1
23.6
29
7
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.0
23.2
360
2044
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
4.0
23.1
96
253
FEB10
NOMESCO Finland
Decompression and drainage of pericardium
18.8
23.1
35
19
7464A
ICD-9 Finland
Other congenital anomalies of heart, Congenital insufficiency of aortic valve
+∞
23.0
22
*
FDJ00
NOMESCO Finland
End to end reconstruction of aorta for coarctation
+∞
23.0
22
*
I25.1
ICD-10 Finland
Atherosclerotic heart disease
2.1
22.9
280
1440
PD5CD
NOMESCO Finland
Very extensive CT angiography of aorta
16.7
22.7
36
22
Q20.48
ICD-10 Finland
Single ventricle
84.6
22.7
25
*
207
Kela drug reimbursment
Chronic arrhythmias
2.5
22.6
199
873
R07.4
ICD-10 Finland
Chest pain, unspecified
1.9
22.4
381
2231
74639
ICD-8 Finland
Congenital anomalies of heart, Defectus septi ventriculorum
52.7
22.1
26
5
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
8.0
22.1
50
64
ZXE50
NOMESCO Finland
More than nine and less than 12 hours
6.6
22.0
57
89
FME20
NOMESCO Finland
Transvenous aortic valve replacement via femoral artery
13.4
22.0
38
29
FMD40
NOMESCO Finland
Replacement of aortic root using pulmonary autograft and reimplantation of coronary arteries (Ross)
+∞
21.9
21
*
Q23.8
ICD-10 Finland
Other congenital malformations of aortic and mitral valves
+∞
21.9
21
*
FDF05
NOMESCO Finland
Percutaneous transluminal occlusion of aorto-pulmonary collaterals
81.2
21.7
24
*
FAE10
NOMESCO Finland
Bidirectional anastomosis between superior vena cava and pulmonary artery
222.7
21.6
22
*
Q25.48
ICD-10 Finland
Other congenital malformations of the aorta
222.7
21.6
22
*
WX882
NOMESCO Finland
High dependency care
3.3
21.1
112
360
7463D
ICD-9 Finland
Other congenital anomalies of heart, Congenital stenosis of aortic valve[BIKUSPINEN AORTALÄPPÄ]
+∞
20.9
20
*
FDJ42
NOMESCO Finland
Percutaneous transluminal angioplasty of thoracic aorta in coarctation
+∞
20.9
20
*
5255
FHL
Deep hypothermia (<20 °) with cardiopulmonary resuscitation
212.4
20.6
21
*
I34.1
ICD-10 Finland
Mitral (valve) prolapse
5.2
20.6
65
130
Q20.1
ICD-10 Finland
Double outlet right ventricle
111.4
20.6
22
*
FXA20
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia and circulatory arrest at concurrent surgical procedure
42.2
20.5
25
6
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
3.3
20.3
107
342
I71.00
ICD-10 Finland
Dissecting aneurysm of aorta (ruptured) [any part]
19.1
20.0
30
16
Z94.1
ICD-10 Finland
Heart transplant status
23.7
20.0
28
12
Q21.0
ICD-10 Finland
Ventricular septal defect
36.2
19.8
25
7
PD5CM
NOMESCO Finland
Extensive MRI examination of thoracal and abdominal aorta with 3 Tesla magnet
202.2
19.6
20
*
TPH04
NOMESCO Finland
Cathetrisation of vein
1.9
19.5
337
1973
FXA13
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia and exclusive cerebral perfusion
+∞
18.8
18
*
Q23.9
ICD-10 Finland
Congenital malformation of aortic and mitral valves, unspecified
+∞
18.8
18
*
I37.0
ICD-10 Finland
Pulmonary valve stenosis
101.1
18.6
20
*
WX704
NOMESCO Finland
Intubation
2.7
18.5
135
532
R01.1
ICD-10 Finland
Cardiac murmur, unspecified
4.5
18.2
65
149
RS224
NOMESCO Finland
NA
8.7
18.2
39
46
Q22.1
ICD-10 Finland
Congenital pulmonary valve stenosis
22.0
18.2
26
12
C09CA01
ATC
losartan; oral
1.9
18.1
314
1835
C09AA02
ATC
enalapril; systemic
2.0
17.7
260
1431
FBE10
NOMESCO Finland
Expansion or reconstruction of pulmonary artery using patch
96.0
17.6
19
*
C07AA07
ATC
sotalol; systemic
4.3
17.4
65
156
Z98.8
ICD-10 Finland
Other specified postsurgical states
6.1
17.3
47
79
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
5.5
17.3
51
95
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.7
17.1
124
488
GAA10
NOMESCO Finland
Intercostal insertion of pleural drainage tube
5.8
17.1
48
84
Z95.4
ICD-10 Finland
Presence of other heart-valve replacement
31.8
17.0
22
7
R06.0
ICD-10 Finland
Dyspnoea
1.8
17.0
325
1963
ZSF00
NOMESCO Finland
Procedure related to previous procedure classified in chapter F
35.4
16.7
21
6
N02BE01
ATC
paracetamol; systemic, rectal
1.6
16.6
1215
10466
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.8
16.4
112
425
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
2.7
16.2
111
422
FNC10
NOMESCO Finland
Aorto-coronary venous bypass with single distal anastomosis
6.8
16.1
40
60
7AX01
NOMESCO Finland
NA
24.7
16.0
22
9
205
Kela drug reimbursment
Chronic hypertension
1.8
15.9
317
1934
I11.9
ICD-10 Finland
Hypertensive heart disease without (congestive) heart failure
3.8
15.9
68
185
I10
ICD-10 Finland
Essential (primary) hypertension
1.6
15.9
684
5160
R50.9
ICD-10 Finland
Fever, unspecified
1.9
15.7
266
1538
Z3231
NOMESCO Finland
Registered nurse
1.6
15.7
465
3189
C08CA01
ATC
amlodipine; oral
1.7
15.6
433
2915
FAE00
NOMESCO Finland
Anastomosis to pulmonary artery from superior vena cava
85.8
15.6
17
*
I35
ICD-10 Finland
Nonrheumatic aortic valve disorders
19.4
15.6
23
12
81
HP
Angiography of the heart and coronary arteries
3.0
15.3
88
300
FN1CC
NOMESCO Finland
Very extensive angiography of heart and/or coronary arteries
6.8
15.3
38
57
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
2.7
15.3
107
415
FWD00
NOMESCO Finland
Reoperation for superficial haemorrhage in surgery of heart and major thoracic vessels
10.5
15.2
29
28
AA1AD
NOMESCO Finland
CT of head and brain
1.8
14.9
304
1867
I38
ICD-10 Finland
Endocarditis, valve unspecified
32.0
14.8
19
6
I33.9
ICD-10 Finland
Acute endocarditis, unspecified
32.0
14.8
19
6
TFJ02
NOMESCO Finland
Muscle biopsy of heart
21.2
14.7
21
10
FMC20
NOMESCO Finland
Suture of leaflet of aortic valve
80.8
14.6
16
*
I47.1
ICD-10 Finland
Supraventricular tachycardia
3.1
14.5
80
266
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.8
14.2
257
1516
FCC45
NOMESCO Finland
Percutaneous insertion of stent into descending aorta
75.7
13.6
15
*
FBE35
NOMESCO Finland
Percutaneous transluminal angioplasty of pulmonary artery with insertion of stent
75.7
13.6
15
*
FAE30
NOMESCO Finland
Total cavo-pulmonary connection using fenestrated patch
+∞
13.6
13
*
Q23.20
ICD-10 Finland
Congenital mitral stenosis
+∞
13.6
13
*
74699
ICD-8 Finland
Congenital anomalies of heart, Unspecified anomalies of heart
141.0
13.5
14
*
FMC96
NOMESCO Finland
Other operation on aortic valve for insufficiency
141.0
13.5
14
*
FFM10
NOMESCO Finland
Occlusion or excision of atrial appendage externally with a closing device
21.3
13.3
19
9
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
13.3
310
1976
74709
ICD-8 Finland
Other congenital anomalies of circulatory system, Patent ductus arteriosus
40.4
13.2
16
*
C10AA05
ATC
atorvastatin; oral
1.6
13.1
458
3254
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
3.0
12.9
76
265
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.6
12.7
436
3077
XF620
NOMESCO Finland
Examination of circulation with color method
12.4
12.6
22
18
FCB40
NOMESCO Finland
Resection and reconstruction of aortic arch using tube graft
70.4
12.6
14
*
K22
ICPC
Risk factor cardiovascular disease
2.9
12.6
78
281
I37.1
ICD-10 Finland
Pulmonary valve insufficiency
32.3
12.6
16
5
Q21.11
ICD-10 Finland
Paten or persistent foramen ovale
6.0
12.6
34
58
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
3.0
12.6
72
246
FPE30
NOMESCO Finland
Replacement of transvenous cardiac pacemaker pulse generator
9.4
12.5
25
27
FBE32
NOMESCO Finland
Percutaneous transluminal angioplasty of pulmonary artery
24.5
12.5
17
7
FLE96
NOMESCO Finland
Other repair of outlet obstruction of left ventricle
130.9
12.4
13
*
TFC10
NOMESCO Finland
Catheterisation of left atrium or ventricle
6.1
12.4
33
55
G04BE03
ATC
sildenafil; oral
4.6
12.3
42
94
FQA00
NOMESCO Finland
Orthotopic transplantation of heart
37.8
12.2
15
*
I71.09
ICD-10 Finland
Aortic dissection [regardless of location]
12.5
12.1
21
17
K29
ICPC
Cardiovascular sympt/complt other
3.3
12.1
61
192
PA1BD
NOMESCO Finland
Extensive CT of aortic arch and branches
47.0
11.9
14
*
Q21.21
ICD-10 Finland
Atrioventricular duct
47.0
11.9
14
*
I49.3
ICD-10 Finland
Ventricular premature depolarization
2.4
11.8
96
406
FM1BD
NOMESCO Finland
Extensive CT of heart
14.8
11.8
19
13
WX870
NOMESCO Finland
Other postsurgical intensive care
9.0
11.7
24
27
FPD10
NOMESCO Finland
Surgical ablation of atrial fibrillation
30.2
11.6
15
5
FXD00
NOMESCO Finland
Use of ECHLA without concurrent surgical procedure
30.2
11.6
15
5
XQ903
NOMESCO Finland
Production of other scan or drawing
23.0
11.6
16
7
FBA96
NOMESCO Finland
Other suture or repair of pulmonary artery
+∞
11.5
11
*
FMA20
NOMESCO Finland
Plastic repair of aortic valve for stenosis
+∞
11.5
11
*
FGD00
NOMESCO Finland
Repair of tricuspid valve using suture
+∞
11.5
11
*
7468X
ICD-9 Finland
Other congenital anomalies of heart, Other specified anomalies of heart[MUU SYDÄMEN EPÄMUODOSTUMA]
+∞
11.5
11
*
7466A
ICD-9 Finland
Other congenital anomalies of heart, Congenital mitral insufficiency
+∞
11.5
11
*
Q23.1
ICD-10 Finland
Congenital insufficiency of aortic valve
+∞
11.5
11
*
74679
ICD-8 Finland
Congenital anomalies of heart, Aliae malformationes valvulae aortae sive ventriculi sinistri
120.7
11.4
12
*
GAB00
NOMESCO Finland
Emergency thoracotomy
120.7
11.4
12
*
90492
NOMESCO Finland
NA
120.7
11.4
12
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.0
11.2
139
712
211
HP
AVR mechanical
25.2
11.1
15
6
FFC22
NOMESCO Finland
Percutaneous transluminal closure of ostium secundum type ASD
12.8
11.1
19
15
I71.1
ICD-10 Finland
Thoracic aortic aneurysm, ruptured
20.2
11.1
16
8
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
2.3
11.1
102
458
I50.0
ICD-10 Finland
Congestive heart failure
2.6
11.0
78
306
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
3.4
10.9
52
157
I50.1
ICD-10 Finland
Left ventricular failure
2.9
10.8
65
232
ZX199
NOMESCO Finland
Other rote
7.2
10.8
25
35
7454B
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Ventricular septal defect[DEFECTUS SEPTI VENTRICULORUM SIMPLEX]
28.2
10.7
14
5
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
2.2
10.6
113
542
Q25.21
ICD-10 Finland
Interrupted aortic arch
110.6
10.4
11
*
74619
ICD-8 Finland
Congenital anomalies of heart, Transposition of great vessels
+∞
10.4
10
*
FHB50
NOMESCO Finland
Transatrial closure of VSD using patch
18.9
10.3
15
8
RK260
NOMESCO Finland
NA
18.9
10.3
15
8
FM1AD
NOMESCO Finland
CT of heart
23.5
10.2
14
6
H53.1
ICD-10 Finland
Subjective visual disturbances
2.3
10.2
93
415
WX002
NOMESCO Finland
Sedation and analgesia
1.6
10.2
251
1619
AP3
HP
Catheterization of the right and left side of the heart
13.2
10.2
17
13
AP1
HP
Catheterization of the left side of the heart
4.7
10.1
33
71
Q21.19
ICD-10 Finland
Atrial septal defect NOS
11.4
10.1
18
16
I47.2
ICD-10 Finland
Ventricular tachycardia
4.0
10.0
39
100
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
1.9
9.9
142
770
602
Kela drug reimbursment
Children's severe malnutrition
4.0
9.9
38
96
FKD00
NOMESCO Finland
Replacement of mitral valve using mechanical prosthesis
16.8
9.9
15
9
TFP34
NOMESCO Finland
Electrophysiological investigation
3.0
9.9
56
190
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.6
9.9
249
1613
FXF00
NOMESCO Finland
Decannulation after ECHLA or ECLA
26.2
9.8
13
5
FM1CD
NOMESCO Finland
Very extensive CT of heart
9.6
9.8
19
20
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.3
9.7
90
406
1EA01
NOMESCO Finland
NA
55.3
9.6
11
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.5
9.6
481
3644
R55
ICD-10 Finland
Syncope and collapse
1.9
9.5
137
744
C09AA04
ATC
perindopril; oral
2.5
9.5
71
287
ZX120
NOMESCO Finland
Intravenous
1.9
9.5
140
767
GAB20
NOMESCO Finland
Median sternotomy
100.5
9.4
10
*
3A566
NOMESCO Finland
NA
100.5
9.4
10
*
Q26.1
ICD-10 Finland
Persistent left superior vena cava
17.6
9.4
14
8
Q21.30
ICD-10 Finland
Tetralogy of Fallot
17.6
9.4
14
8
74659
ICD-8 Finland
Congenital anomalies of heart, Maleformatio valvulae mitralis
+∞
9.4
9
*
Q25.9
ICD-10 Finland
Congenital malformation of great arteries, unspecified
+∞
9.4
9
*
FCA96
NOMESCO Finland
Other repair of ascending aorta
+∞
9.4
9
*
FDA96
NOMESCO Finland
Other operation for HLHS
+∞
9.4
9
*
FJF10
NOMESCO Finland
Replacement of pulmonary valve using biological prosthesis
+∞
9.4
9
*
I31.3
ICD-10 Finland
Pericardial effusion (noninflammatory)
12.4
9.4
16
13
I49.4
ICD-10 Finland
Other and unspecified premature depolarization
2.9
9.3
54
188
M01AE01
ATC
ibuprofen; systemic, rectal
0.7
9.3
1096
12132
1CX08
NOMESCO Finland
NA
10.7
9.3
17
16
127
Kela drug reimbursment
Transplant complication
3.3
9.3
45
139
FKB10
NOMESCO Finland
Annuloplasty of mitral valve for insufficiency using ring
5.7
9.2
25
44
I71.01
ICD-10 Finland
Aneurysm of the descending aorta
13.7
9.2
15
11
3A064
NOMESCO Finland
NA
15.7
9.0
14
9
7455A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Ostium secundum type atrial septal defect
36.9
9.0
11
*
Q24.8
ICD-10 Finland
Other specified congenital malformations of heart
36.9
9.0
11
*
7470A
ICD-9 Finland
Other congenital anomalies of circulatory system, Patent ductus arteriosus
36.9
9.0
11
*
C09CA06
ATC
candesartan; oral
1.6
9.0
249
1652
I34.2
ICD-10 Finland
Nonrheumatic mitral (valve) stenosis
18.7
8.9
13
7
Z50.0
ICD-10 Finland
Cardiac rehabilitation
5.5
8.9
25
46
A41.9
ICD-10 Finland
Sepsis, unspecified
2.7
8.9
57
213
I34.9
ICD-10 Finland
Nonrheumatic mitral valve disorder, unspecified
8.6
8.8
18
21
FPJ04
NOMESCO Finland
Revision of pacemaker generator with atrial and ventricular electrodes
14.1
8.7
14
10
Q25.78
ICD-10 Finland
Other congenital malformations of pulmonary artery
50.2
8.7
10
*
4241B
ICD-9 Finland
Other diseases of endocardium, Aortic valve disorders[STENOSIS VALVULAE AORTAE (NON RHEUMATICA)]
50.2
8.7
10
*
FPF20
NOMESCO Finland
Implantation of epicardial pacemaker with atrial and ventricular electrodes
50.2
8.7
10
*
UGC02
NOMESCO Finland
Rigid bronchoscopy
6.6
8.7
21
32
R04.0
ICD-10 Finland
Epistaxis
2.1
8.6
97
481
FJF20
NOMESCO Finland
Replacement of pulmonary valve using homograft
27.6
8.5
11
*
R42
ICD-10 Finland
Dizziness and giddiness
1.6
8.5
229
1508
5207
FHL
VSD closure
90.4
8.4
9
*
K73
ICPC
Congenital anomaly cardiovascular
90.4
8.4
9
*
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
2.0
8.4
106
548
J01DB01
ATC
cefalexin; oral
1.4
8.4
1197
10804
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
2.2
8.4
79
362
B34.9
ICD-10 Finland
Viral infection, unspecified
2.5
8.4
64
263
7451B
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Transposition of great vessels[DOUBLE OUTLET RIGHT VENTRICLE]
+∞
8.3
8
*
7465A
ICD-9 Finland
Other congenital anomalies of heart, Congenital mitral stenosis
+∞
8.3
8
*
74729
ICD-8 Finland
Other congenital anomalies of circulatory system, Maleformationes aortae aliae
+∞
8.3
8
*
Q32.11
ICD-10 Finland
Congenital tracheo-esophageal fissure
+∞
8.3
8
*
FDH96
NOMESCO Finland
Other operation for interrupted or hypoplastic aortic arch
+∞
8.3
8
*
I49.5
ICD-10 Finland
Sick sinus syndrome
3.1
8.3
44
146
XF602
NOMESCO Finland
Bloodpressure monitoring
4.2
8.3
30
73
ZXX09
NOMESCO Finland
Extent of procedure, more than 8 units
14.5
8.2
13
9
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
2.2
8.2
82
386
SAA03
NOMESCO Finland
Extended examination of mouth
1.4
8.1
600
4852
FCC50
NOMESCO Finland
Resection and reconstruction of descending aorta using tube graft
33.5
8.1
10
*
Q87.4
ICD-10 Finland
Marfan syndrome
33.5
8.1
10
*
FJE42
NOMESCO Finland
Percutaneous transluminal expansion of pulmonary valve
33.5
8.1
10
*
4241A
ICD-9 Finland
Other diseases of endocardium, Aortic valve disorders[INSUFFICIENTIA VALVULAE AORTAE (NON RHEUMATICA)]
17.2
8.1
12
7
Z3226
NOMESCO Finland
Physiotherapist
1.5
8.0
273
1899
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
3.7
8.0
33
90
324
NOMESCO Finland
NA
22.1
8.0
11
5
Q22.0
ICD-10 Finland
Pulmonary valve atresia
22.1
8.0
11
5
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
3.9
7.9
31
81
A02BC02
ATC
pantoprazole; systemic
1.3
7.9
794
6738
C03EB01
ATC
furosemide and potassium-sparing agents; systemic
3.2
7.9
40
129
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
1.9
7.9
120
669
I36.1
ICD-10 Finland
Nonrheumatic tricuspid (valve) insufficiency
5.4
7.8
22
41
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
4.9
7.8
24
50
PH1AC
NOMESCO Finland
Flebography of over extremity with X-ray
5.1
7.7
23
46
Q24.3
ICD-10 Finland
Pulmonary infundibular stenosis
45.2
7.7
9
*
7454A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Ventricular septal defect[DEFECTUS SEPTI VENTRICULORUM NUD]
45.2
7.7
9
*
FMC10
NOMESCO Finland
Reduction of leaflet of aortic valve
45.2
7.7
9
*
7460C
ICD-9 Finland
Other congenital anomalies of heart, Anomalies of pulmonary valve[VITIUM VALVULAE PULMONALIS CONGENITA CUM STENOSIS]
45.2
7.7
9
*
Q21.9
ICD-10 Finland
Congenital malformation of cardiac septum, unspecified
15.1
7.7
12
8
FPH00
NOMESCO Finland
Transvenous extraction of transvenous cardiac pacemaker or cardioverter-defibrillator
15.1
7.7
12
8
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.5
7.7
273
1916
3A077
NOMESCO Finland
NA
18.4
7.6
11
6
FFC00
NOMESCO Finland
Suture of ostium secundum type ASD
11.9
7.6
13
11
3A422
NOMESCO Finland
NA
25.1
7.6
10
*
TFC20
NOMESCO Finland
Catheterisation of both sides of heart
25.1
7.6
10
*
I44.1
ICD-10 Finland
Atrioventricular block, second degree
3.9
7.6
29
75
XA800
NOMESCO Finland
Neuropsychological investigation
2.0
7.5
89
453
26
HP
Aortic root """"composite graft""""
80.4
7.4
8
*
FAE96
NOMESCO Finland
Other connection to pulmonary artery from superior vena cava
80.4
7.4
8
*
74663
ICD-8 Finland
Congenital anomalies of heart, Stenosis valvulae pulmonalis
80.4
7.4
8
*
C07AB03
ATC
atenolol; systemic
2.3
7.4
62
270
PA6AE
NOMESCO Finland
Ulrasound examination of neck vasculature
5.3
7.4
21
40
TGW99
NOMESCO Finland
Other minor procedure in thoracic surgery
13.4
7.4
12
9
4241C
ICD-9 Finland
Other diseases of endocardium, Aortic valve disorders[INSUFFICIENTIA/STENOSIS VALVULAE AORTAE (NON RHEUM)]
+∞
7.3
7
*
PD5DM
NOMESCO Finland
Very extensive MRI examination of thoracal and abdominal aorta with 3 Tesla magnet
+∞
7.3
7
*
FXM00
NOMESCO Finland
Removal of extra-, para- or intracorporeal VAD
+∞
7.3
7
*
FLE00
NOMESCO Finland
Excision of subvalvular membrane of left ventricle
+∞
7.3
7
*
FDJ30
NOMESCO Finland
Reconstruction of aorta for coarctation using tube graft
+∞
7.3
7
*
Q25.4
ICD-10 Finland
Other congenital malformations of aorta
+∞
7.3
7
*
I37.2
ICD-10 Finland
Pulmonary valve stenosis with insufficiency
+∞
7.3
7
*
AP2
HP
Catheterization of the right side of the heart
15.8
7.2
11
7
I49.1
ICD-10 Finland
Atrial premature depolarization
2.7
7.2
46
172
XF405
NOMESCO Finland
Symptom ECG
4.8
7.1
22
46
SPAT1249
SPAT
Treatment-related counselling outside office
1.4
7.1
525
4225
1AB02
NOMESCO Finland
NA
12.1
7.1
12
10
R31
ICD-10 Finland
Unspecified haematuria
1.8
7.0
120
693
Z95.9
ICD-10 Finland
Presence of cardiac and vascular implant and graft, unspecified
8.8
7.0
14
16
Z95.1
ICD-10 Finland
Presence of aortocoronary bypass graft
2.4
7.0
54
226
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
3.0
7.0
37
124
R62.0
ICD-10 Finland
Delayed milestone
3.0
7.0
37
124
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
2.9
6.9
38
131
342
Kela drug reimbursment
Dronedarone
7.6
6.9
15
20
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
2.1
6.9
71
341
TFP35
NOMESCO Finland
Electroanatomical mapping
3.7
6.9
28
77
FM1DE
SPAT
NA
8.3
6.8
14
17
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
3.6
6.8
28
78
74689
ICD-8 Finland
Congenital anomalies of heart, Aliae definitae
40.2
6.8
8
*
Q20.40
ICD-10 Finland
Double inlet left ventricle
40.2
6.8
8
*
5609
FHL
Other measure in this category
40.2
6.8
8
*
FQA10
NOMESCO Finland
Orthotopic transplantation of heart with bicaval anastomosis
40.2
6.8
8
*
I71.6
ICD-10 Finland
Thoracoabdominal aortic aneurysm, without mention of rupture
16.7
6.7
10
6
Q25.6
ICD-10 Finland
Stenosis of pulmonary artery
22.6
6.7
9
*
Y0399
ICD-8 Finland
Investigation of circulatory system
5.5
6.6
18
33
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
2.4
6.6
51
215
GD1AD
NOMESCO Finland
Thorax CT examination
2.2
6.5
63
292
Z2446
NOMESCO Finland
Social worker
1.7
6.5
134
823
R00.2
ICD-10 Finland
Palpitations
2.0
6.5
83
433
ZXE60
NOMESCO Finland
More than 12 and less than 15 hours
5.0
6.5
19
38
FJA10
NOMESCO Finland
Transvenous biopsy of right ventricle
6.2
6.5
16
26
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.6
6.5
151
958
Z34.8
ICD-10 Finland
Supervision of other normal pregnancy
0.4
6.4
26
632
FDB20
NOMESCO Finland
Arterial switch operation for other congenital heart defect
70.1
6.4
7
*
L04AA06
ATC
mycophenolic acid; systemic
2.7
6.4
39
144
Q25.41
ICD-10 Finland
Persistent right-sided aortic arch
14.3
6.4
10
7
J01FA06
ATC
roxithromycin; oral
1.3
6.4
467
3738
AA5HE
NOMESCO Finland
Brain ultrasound examination in a child
3.1
6.4
32
104
FN1AD
NOMESCO Finland
CT of coronary arteries
3.9
6.4
24
62
SPAT1263
SPAT
Sampling
1.3
6.4
549
4508
J21.0
ICD-10 Finland
Acute bronchiolitis due to respiratory syncytial virus
3.3
6.4
29
88
K80
ICPC
Cardiac arrhythmia NOS
2.0
6.3
80
416
A40.8
ICD-10 Finland
Other streptococcal sepsis
4.6
6.3
20
44
I20.81
ICD-10 Finland
Other angina pectoris stenosed coronary artery
1.9
6.3
84
450
FDJ20
NOMESCO Finland
Aortoplasty for coarctation using patch
+∞
6.2
6
*
FDG10
NOMESCO Finland
Reconstruction of ascending aorta for supravalvular aortic stenosis using patch
+∞
6.2
6
*
FFK20
NOMESCO Finland
Atrio-pulmonary anastomosis
+∞
6.2
6
*
0557
NOMESCO Finland
NA
+∞
6.2
6
*
FDH10
NOMESCO Finland
Reconstruction of interrupted or hypoplastic aortic arch using patch
+∞
6.2
6
*
474
NOMESCO Finland
NA
26.8
6.2
8
*
D73.5
ICD-10 Finland
Infarction of spleen
26.8
6.2
8
*
I28.8
ICD-10 Finland
Other specified diseases of pulmonary vessels
26.8
6.2
8
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.5
6.2
195
1332
N02AX02
ATC
tramadol; systemic, rectal
1.3
6.2
509
4143
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
2.7
6.2
40
150
-
ICD-10 Finland
NA
3.1
6.2
31
101
Z01.2
ICD-10 Finland
Dental examination
1.3
6.2
607
5069
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
2.7
6.2
40
151
C10AA03
ATC
pravastatin; oral
2.0
6.2
75
387
GD1LA
NOMESCO Finland
GD
3.6
6.1
25
70
Z71.8
ICD-10 Finland
Other specified counselling
1.4
6.0
315
2382

Mortality – FinRegistry

↥

Association

Association between endpoint Q17_LVOTO_NARROW and mortality.

Females

Parameter HR [95% CI] p-value
Q17_LVOTO_NARROW 2.247 [1.81, 2.8] < 0.001
Birth year 0.991 [0.98, 1.0] 0.053

During the follow-up period (1.1.1998 — 31.12.2019), 263 out of 3839 females with Q17_LVOTO_NARROW died.

Males

Parameter HR [95% CI] p-value
Q17_LVOTO_NARROW 1.537 [1.3, 1.81] < 0.001
Birth year 0.99 [0.98, 1.0] 0.082

During the follow-up period (1.1.1998 — 31.12.2019), 418 out of 6581 males with Q17_LVOTO_NARROW died.

Mortality risk

Mortality risk for people of age

years, who have Q17_LVOTO_NARROW.

N-year risk Females Males
1 0.212% 0.276%
5 1.202% 1.713%
10 2.968% 4.62%
15 5.465% 8.948%
20 9.766% 15.278%

Relationships between endpoints

↥

Index endpoint: Q17_LVOTO_NARROW – Left ventricular outflow tract obstruction, narrow definition

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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