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Congenital aortic valve stenosis

Endpoint Browser PheWeb

Q17_CONGENITAL_AORTIC_VALVE_STENOSIS

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — Q23.0
  • Hospital discharge: ICD-9 — 7463A|7463B|7463D|7463X
  • Cause of death: ICD-10 — Q23.0
  • Cause of death: ICD-9 — 7463A|7463B|7463D|7463X

2 out of 7 registries used, show all original rules.

179

4. Check minimum number of events

None

179

5. Include endpoints

None

179

6. Filter based on genotype QC (FinnGen only)

167

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 167 58 109
Unadjusted period prevalence (%) 0.04 0.02 0.05
Median age at first event (years) 11.87 10.38 12.66

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
179
Matched controls
1790
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q23.0
ICD-10 Finland
Congenital stenosis of aortic valve
+∞
171.7
136
*
I35.0
ICD-10 Finland
Aortic (valve) stenosis
77.8
127.0
71
15
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
68.9
110.8
63
14
Q23.11
ICD-10 Finland
Bicuspid aortic valve
596.2
99.7
90
*
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
32.4
95.6
69
34
B01AA03
ATC
warfarin; systemic
23.1
95.2
86
69
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
19.3
92.9
121
175
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
25.6
90.8
74
48
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
19.1
89.1
94
98
201
Kela drug reimbursment
Chronic cardiac insufficiency
47.8
80.2
49
14
I35.2
ICD-10 Finland
Aortic (valve) stenosis with insufficiency
176.8
50.8
51
*
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
133.7
47.6
49
5
7463A
ICD-9 Finland
Other congenital anomalies of heart, Congenital stenosis of aortic valve[STENOSIS VALVULAE AORTAE CONGENITA]
+∞
43.5
40
*
XF402
NOMESCO Finland
ECG with work load test
14.6
43.0
43
38
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
10.7
40.6
52
66
C03CA01
ATC
furosemide; systemic
8.3
38.7
66
118
Q25.1
ICD-10 Finland
Coarctation of aorta
165.0
38.4
39
*
Q23.10
ICD-10 Finland
Congenital insufficiency of aortic valve
239.4
38.4
38
*
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
18.2
38.4
33
22
XF400
NOMESCO Finland
ECG with 12 standard connections
7.6
38.1
75
156
XF404
NOMESCO Finland
Ambulatory ECG
10.8
33.7
41
48
I71.2
ICD-10 Finland
Thoracic aortic aneurysm, without mention of rupture
49.3
32.8
39
10
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
6.5
30.6
66
147
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.7
29.6
111
400
FMD00
NOMESCO Finland
Replacement of aortic valve using mechanical prosthesis
178.9
29.6
30
*
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
8.4
28.1
42
63
C07AB07
ATC
bisoprolol; oral
5.4
27.7
85
257
XF600
NOMESCO Finland
Bloodpressure measurement
7.1
26.0
46
83
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
7.3
25.6
44
77
TPH07
NOMESCO Finland
Cathetrisation of artery
6.7
24.5
46
88
XFE00
NOMESCO Finland
Epicardial ultrasonography
42.9
23.8
29
8
ZXE20
NOMESCO Finland
More than three and less than five hours
6.0
23.5
51
112
7463D
ICD-9 Finland
Other congenital anomalies of heart, Congenital stenosis of aortic valve[BIKUSPINEN AORTALÄPPÄ]
+∞
23.4
22
*
B01AB05
ATC
enoxaparin; parenteral
5.0
22.4
64
178
FM2CE, ,
NOMESCO Finland
8.6
21.5
30
41
FMD40
NOMESCO Finland
Replacement of aortic root using pulmonary autograft and reimplantation of coronary arteries (Ross)
+∞
21.3
20
*
ZXE30
NOMESCO Finland
More than five and less than seven hours
7.4
20.5
33
53
5273
FHL
Repair with flap prosthesis or graft
+∞
20.2
19
*
K83
ICPC
Heart valve disease NOS
223.7
20.0
20
*
61
HP
Catheterization and pressure measurement of the left side of the heart
52.4
19.7
23
5
C03DA01
ATC
spironolactone; oral
7.0
18.0
30
50
5253
FHL
Cardiac lung machine
105.7
17.9
19
*
WX872
NOMESCO Finland
Intensive care
14.8
17.9
30
24
C01AA05
ATC
digoxin; systemic
17.2
17.8
28
19
I48
ICD-10 Finland
Atrial fibrillation and flutter
6.1
16.5
32
62
7471A
ICD-9 Finland
Other congenital anomalies of circulatory system, Coarctation of aorta[COARCTATIO AORTAE]
+∞
15.9
15
*
Q24.4
ICD-10 Finland
Congenital subaortic stenosis
+∞
15.9
15
*
31
HP
Congenital heart failure surgery
42.2
15.7
19
5
WX408
NOMESCO Finland
General anesthesy, balanced
3.6
15.1
76
307
Q21.09
ICD-10 Finland
Ventricular septal defect NOS
62.2
15.1
17
*
FM1DG
NOMESCO Finland
Very extensive MRI examination of heart with high intesity magnet
17.4
14.9
23
15
FCA60
NOMESCO Finland
Resection of aortic root and ascending aorta with reimplantation of coronary arteries and use of composite graft with mechanical valve prosthesis
87.5
14.8
16
*
XF640, ,
NOMESCO Finland
26.4
14.1
19
8
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
81.1
13.8
15
*
Q25.40
ICD-10 Finland
Aortic hypoplasia
+∞
13.7
13
*
74673
ICD-8 Finland
Congenital anomalies of heart, Stenosis valvulae aortae
+∞
13.7
13
*
207
Kela drug reimbursment
Chronic arrhythmias
6.6
13.4
23
39
ZXD10
NOMESCO Finland
Scheduled procedure
3.1
12.7
89
430
WX892
NOMESCO Finland
Monitored bed care
5.1
12.7
29
65
Q25.0
ICD-10 Finland
Patent ductus arteriosus
20.7
11.8
17
9
Q21.00
ICD-10 Finland
Multiple ventricular septal defect
24.9
11.8
16
7
WZC30
NOMESCO Finland
Teaching
4.0
11.6
38
113
Q25.3
ICD-10 Finland
Stenosis of aorta
+∞
11.6
11
*
TFC99
NOMESCO Finland
Catheterisation of heart with other procedure
15.2
11.2
18
13
ZXE10
NOMESCO Finland
More than one and less than three hours
2.9
10.8
76
361
Q20.3
ICD-10 Finland
Discordant ventriculoarterial connection
63.9
10.8
12
*
Z2221
NOMESCO Finland
Medical doctor
3.0
10.7
70
320
C07AA07
ATC
sotalol; systemic
17.4
10.6
16
10
PD5CG
NOMESCO Finland
Extensive MRI examination of thoracal and abdominal aortta with high intensity magnet
116.6
10.5
11
*
FMA20
NOMESCO Finland
Plastic repair of aortic valve for stenosis
+∞
10.5
10
*
TFP20
NOMESCO Finland
Cardiodefibrillation
12.4
10.3
18
16
Z98.8
ICD-10 Finland
Other specified postsurgical states
23.2
9.5
13
6
Q23.9
ICD-10 Finland
Congenital malformation of aortic and mitral valves, unspecified
+∞
9.5
9
*
ZXE40
NOMESCO Finland
More than seven and less than nine hours
9.9
9.3
18
20
GAE10
NOMESCO Finland
Closure of previous incision of chest wall
16.7
9.2
14
9
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
25.6
9.0
12
5
FM1CG
NOMESCO Finland
Extensive examination of hear with high intensity magnet
25.6
9.0
12
5
ZXD05
NOMESCO Finland
Urgent procedure
2.7
8.7
66
321
PD5BG
NOMESCO Finland
MRI examination of thoracal and abdominal aortta with high intensity magnet
94.3
8.5
9
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.9
8.5
47
193
FC1BC
NOMESCO Finland
Extensive angiography of thoracal aortta
+∞
8.4
8
*
FCA50
NOMESCO Finland
Resection and reconstruction of ascending aorta using tube graft
+∞
8.4
8
*
I50.9
ICD-10 Finland
Heart failure, unspecified
4.9
8.3
19
42
Z01.8
ICD-10 Finland
Other specified special examinations
2.8
8.3
50
215
Q21.08
ICD-10 Finland
Other specifed ventricular septal defect
9.6
8.2
16
18
I71.9
ICD-10 Finland
Aortic aneurysm of unspecified site, without mention of rupture
35.1
8.2
10
*
R4110
NOMESCO Finland
Physiotherapy
2.6
8.1
65
323
C09AA02
ATC
enalapril; systemic
3.9
8.0
25
71
ZX120
NOMESCO Finland
Intravenous
3.9
7.7
24
68
I47.1
ICD-10 Finland
Supraventricular tachycardia
7.7
7.7
17
24
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
10.7
7.7
14
14
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
2.5
7.5
65
332
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
4.3
7.4
20
51
XF622
NOMESCO Finland
Measurement of minute volume of heart
16.6
7.3
11
7
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
16.6
7.3
11
7
O99.4
ICD-10 Finland
Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium
31.4
7.2
9
*
62
HP
Catheterization and pressure measurement of the right side of the heart
31.4
7.2
9
*
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
10.7
7.2
13
13
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.6
7.1
52
245
Q21.10
ICD-10 Finland
Persistent ostium secundum
8.8
7.0
14
17
C07AB02
ATC
metoprolol; systemic
3.5
6.9
26
84
K84
ICPC
Heart disease other
17.5
6.8
10
6
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
41.7
6.8
8
*
FMD10
NOMESCO Finland
Replacement of aortic valve using biological prosthesis
41.7
6.8
8
*
I33.0
ICD-10 Finland
Acute and subacute infective endocarditis
23.5
6.7
9
*
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.3
6.7
92
569
81
HP
Angiography of the heart and coronary arteries
12.9
6.7
11
9
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
10.6
6.6
12
12
I35.9
ICD-10 Finland
Aortic valve disorder, unspecified
72.3
6.5
7
*
Q25.48
ICD-10 Finland
Other congenital malformations of the aorta
72.3
6.5
7
*
WX402
NOMESCO Finland
General anaesthesia
2.4
6.3
53
265
74719
ICD-8 Finland
Other congenital anomalies of circulatory system, Coarctation of aorta
+∞
6.3
6
*
5513
FHL
Coarctation resection, plastic or bypass
+∞
6.3
6
*
AP3
HP
Catheterization of the right and left side of the heart
+∞
6.3
6
*
FJE42
NOMESCO Finland
Percutaneous transluminal expansion of pulmonary valve
+∞
6.3
6
*
5255
FHL
Deep hypothermia (<20 °) with cardiopulmonary resuscitation
+∞
6.3
6
*
ZSF00
NOMESCO Finland
Procedure related to previous procedure classified in chapter F
+∞
6.3
6
*
PD5DG
NOMESCO Finland
Very extensive MRI examination of thoracal and abdominal aortta with high intensity magnet
+∞
6.3
6
*
5271
FHL
Valvulotomy
+∞
6.3
6
*
I49.5
ICD-10 Finland
Sick sinus syndrome
13.1
6.2
10
8
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
3.3
6.1
24
80

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
132
182
24.81
106.97
7.7
5.4
647.23
911.51
ng/l
0.83
124
148
58
67
12.33
49.05
4.4
4.3
121.68
146.87
ng/l
0.28
53
60
123
403
7.56
39.24
51.5
7.7
2.22
1.17
inr
8.03
31
134
47
66
9.30
33.56
2.5
2.4
16.76
11.08
ug/l
0.56
47
60
136
719
4.71
19.19
5.4
2.8
—
—
—
0
0
72
263
3.91
16.96
5.0
4.4
—
—
—
0
0
79
309
3.79
16.79
4.4
2.8
52.99
29.15
ng/l
0.85
58
160
31
63
5.74
15.16
33.2
15.4
0.83
0.70
%
1.48
31
63
86
375
3.49
15.15
3.5
2.6
—
—
—
0
0
30
64
5.43
13.88
33.7
15.2
1.39
1.65
%
0.43
30
64
126
727
3.48
13.48
14.8
7.2
6.28
6.49
mmol/l
0.78
121
671
42
125
4.08
12.88
1.8
1.6
—
—
—
0
0
105
572
3.02
11.87
8.9
7.3
18.47
12.63
umol/l
1.40
99
545
45
153
3.59
11.31
2.4
2.1
—
—
—
0
0
101
549
2.93
11.29
3.9
2.8
—
—
—
0
0
53
209
3.18
10.44
5.4
3.2
—
—
—
0
0
60
256
3.02
10.30
6.5
3.2
1.57
1.21
mg/l
0.35
38
194
36
112
3.77
10.25
30.2
15.4
0.57
1.01
mmol/l
0.28
31
92
40
136
3.50
9.97
19.8
12.3
107.05
104.19
mmol/l
4.34
40
136
23
52
4.93
9.87
9.0
14.5
0.81
0.67
%
1.56
23
52
35
111
3.68
9.67
31.1
15.4
5.43
5.27
kpa
0.54
35
104
35
111
3.68
9.67
31.1
15.4
15.81
13.75
kpa
1.41
35
105
20
25
8.86
9.64
10.1
22.7
74.31
73.00
%
0.13
20
25
24
60
4.46
9.12
41.3
20.9
—
—
—
0
0
23
56
4.57
9.03
9.0
13.5
1.14
1.71
%
1.70
23
56
167
1318
4.98
8.01
30.2
13.3
139.24
139.49
mmol/l
0.90
167
1282
167
1327
4.86
7.72
30.0
13.2
4.01
3.95
mmol/l
1.79
167
1289
40
162
2.89
7.32
15.8
9.7
5.01
5.02
kpa
0.06
40
154
17
26
7.11
7.31
11.8
23.2
—
—
—
0
0
29
99
3.30
7.08
8.1
4.9
77.83
64.57
e9/l
1.01
23
72
34
131
2.97
6.78
17.6
10.4
9.81
9.73
kpa
0.11
34
125
92
573
2.25
6.57
19.3
11.7
1.19
1.22
mmol/l
2.74
87
516
43
191
2.65
6.57
31.7
13.5
25.15
25.05
mmol/l
0.09
43
191
35
143
2.80
6.26
15.7
8.8
—
—
—
0
0
86
532
2.19
6.14
26.5
11.7
1.18
1.22
mmol/l
4.16
86
503
45
211
2.51
6.12
10.5
9.8
1.54
1.49
mmol/l
0.04
40
167
56
297
2.29
5.76
2.5
3.0
3.57
2.82
mg/l
1.21
51
258
48
241
2.36
5.59
11.2
10.7
1.29
1.24
mmol/l
0.47
48
233
43
206
2.43
5.55
31.5
10.5
—
—
—
0
0
30
126
2.66
5.06
42.3
14.0
1.57
1.50
mmol/l
0.11
30
120
11
18
6.43
4.68
8.3
30.5
11.67
12.34
%
0.29
11
18
72
451
2.00
4.67
1.5
1.5
—
—
—
0
0
168
1453
3.54
4.46
20.5
9.3
—
—
—
0
0
26
119
2.39
3.66
1.2
1.2
—
—
—
0
0
162
1411
2.56
3.53
23.1
11.5
39.40
23.11
mg/l
5.60
140
988
83
588
1.77
3.42
3.3
3.1
108.46
84.15
ug/l
0.55
77
556
97
720
1.76
3.39
10.9
10.6
0.00
0.00
e9/l
0.38
84
566
10
23
4.54
3.36
5.5
5.0
3.99
3.84
mmol/l
—
10
23
7
12
6.02
3.05
3.3
1.4
33.86
33.08
pg
—
7
12
10
26
4.01
3.03
1.8
8.2
—
—
—
0
0
115
913
1.73
3.02
7.6
6.6
90.87
97.66
u/l
0.54
115
865
11
34
3.38
2.78
3.6
3.1
—
—
—
0
0
5
7
7.31
2.56
1.4
1.4
—
—
—
0
0
24
124
2.08
2.55
1.3
1.3
424.80
367.53
u/ml
0.07
24
109
31
177
1.91
2.51
2.6
1.7
—
—
—
0
0
95
740
1.60
2.50
8.2
9.2
—
—
—
0
0
8
21
3.94
2.49
3.0
7.7
5.15
4.92
kpa
—
8
21
8
21
3.94
2.49
3.0
7.7
6.95
9.00
kpa
—
8
21
11
38
3.02
2.46
6.4
7.8
—
—
—
0
0
46
301
1.71
2.39
3.8
3.8
0.13
0.01
estimate
0.43
15
97
5
8
6.39
2.38
1.2
3.1
—
—
—
0
0
5
8
6.39
2.38
1.2
3.1
107.00
107.00
mmol/l
—
5
8
5
8
6.39
2.38
1.2
3.1
3.90
3.95
mmol/l
—
5
8
64
461
1.60
2.29
6.2
4.6
347.64
27.71
e6/l
0.61
53
322
6
14
4.39
2.17
1.3
1.4
—
—
—
0
0
56
396
1.60
2.14
5.3
4.0
200.64
38.39
e6/l
0.48
49
309
102
827
1.54
2.13
9.3
8.9
0.21
0.21
e9/l
0.15
95
732
99
799
1.53
2.10
7.8
8.3
0.04
0.04
e9/l
0.05
93
694
99
800
1.53
2.08
7.8
8.3
0.59
0.57
e9/l
0.46
93
696
13
58
2.34
1.96
6.7
12.7
—
—
—
0
0
6
16
3.84
1.95
5.8
3.1
—
—
—
0
0
101
828
1.50
1.93
7.7
8.4
1.71
2.07
e9/l
5.35
95
740
172
1622
2.54
1.91
42.0
17.4
38.92
40.99
%
4.28
167
1547
5
12
4.25
1.83
2.4
3.3
6.88
7.26
mmol/l
—
5
12
7
23
3.12
1.82
2.9
14.8
—
—
—
0
0
50
359
1.54
1.76
5.5
3.8
0.52
0.15
e6/l
0.78
42
271
7
24
2.99
1.74
3.1
2.8
—
—
—
0
0
6
19
3.23
1.67
5.8
2.9
—
—
—
0
0
5
14
3.64
1.62
1.8
3.2
1.82
1.38
mmol/l
—
5
14
113
972
1.44
1.54
3.8
3.7
14.87
14.59
pmol/l
0.57
106
906
5
15
3.40
1.53
2.4
2.9
1.26
1.21
mmol/l
—
5
15
5
15
3.40
1.53
9.8
1.1
13.40
13.20
%
—
5
15
7
27
2.66
1.53
2.4
4.5
51.00
67.56
%
—
7
27
7
27
2.66
1.53
2.6
4.4
18.71
6.07
%
—
7
27
9
37
2.51
1.50
17.6
9.8
—
—
—
0
0
9
38
2.44
1.48
1.9
1.7
—
—
—
0
0
57
436
1.45
1.46
6.2
8.2
—
—
—
0
0
9
39
2.38
1.45
1.2
3.1
—
—
—
0
0
5
17
2.99
1.37
1.6
2.4
—
—
—
0
0
40
292
1.48
1.29
3.8
4.3
7.40
7.40
ph
—
9
44
5
18
2.83
1.29
1.6
11.7
—
—
—
0
0
98
839
1.37
1.27
5.2
4.0
—
—
—
0
0
10
186
0.51
1.26
1.3
1.3
—
—
—
0
0
6
25
2.45
1.25
2.8
4.4
18.50
26.08
%
—
6
25
47
361
1.41
1.16
5.7
3.8
—
—
—
0
0
21
137
1.60
1.12
1.5
1.3
—
—
—
0
0
50
391
1.39
1.11
1.9
1.8
—
—
—
0
0
11
59
1.92
1.10
2.0
1.8
—
—
—
0
0
12
67
1.85
1.07
1.2
1.1
—
—
—
0
0
5
22
2.31
1.04
1.2
1.1
—
—
—
0
0
38
288
1.41
1.01
4.7
2.6
—
—
—
0
0
5
23
2.21
0.98
7.2
5.4
4.49
2.53
ug/l
—
5
23
72
608
1.31
0.96
5.8
4.7
0.00
0.00
estimate
-0.00
17
103
6
27
2.26
0.94
1.3
5.8
59.33
49.41
%
—
6
27
102
904
1.30
0.94
12.7
10.7
4.03
3.71
e9/l
0.89
95
778
12
71
1.74
0.91
2.0
1.4
—
—
—
0
0
15
95
1.63
0.90
2.1
7.3
0.00
0.09
%
—
8
33
6
29
2.10
0.90
2.7
4.1
29.87
38.08
%
—
6
29
72
613
1.29
0.89
4.2
3.3
0.00
0.01
estimate
0.50
18
101
6
30
2.03
0.88
2.8
4.6
29.17
17.40
%
—
6
30
6
111
0.52
0.86
4.5
1.6
—
—
—
0
0
20
138
1.51
0.86
3.0
3.7
9.53
9.27
g/l
0.13
20
133
13
81
1.65
0.84
1.2
1.2
—
—
—
0
0
8
46
1.77
0.83
2.9
2.5
—
—
—
0
0
17
114
1.54
0.83
1.9
2.1
1.20
1.03
g/l
0.21
17
109
12
74
1.67
0.80
2.3
1.2
—
—
—
0
0
127
1171
1.29
0.80
4.5
4.1
1.87
1.92
mu/l
0.21
122
1100
10
59
1.74
0.77
1.7
6.0
1.21
1.23
mmol/l
—
10
52
36
448
0.75
0.76
2.3
2.1
—
—
—
0
0
5
27
1.88
0.69
1.2
5.0
3.99
3.22
e9/l
—
5
27
29
226
1.34
0.67
5.7
3.5
1.37
1.95
e6/l
0.28
19
136
15
104
1.48
0.65
2.1
6.9
0.75
0.84
%
—
8
43
0
21
0.00
0.60
0.0
1.1
—
—
—
0
0
0
22
0.00
0.59
0.0
1.4
—
—
—
0
0
0
22
0.00
0.59
0.0
1.1
—
28.22
—
0
17
21
272
0.74
0.59
1.9
1.9
—
—
—
0
0
13
90
1.48
0.57
2.2
7.5
0.00
0.04
%
—
6
27
70
622
1.21
0.55
4.2
3.4
0.00
0.00
estimate
-0.00
16
95
13
93
1.43
0.49
2.2
6.5
2.00
0.57
%
—
6
35
14
102
1.40
0.49
2.4
3.9
—
—
—
0
0
11
79
1.42
0.42
4.0
3.1
—
—
—
0
0
30
252
1.23
0.41
1.7
1.5
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
247.50
—
0
15
0
16
0.00
0.41
0.0
1.8
—
—
—
0
0
0
17
0.00
0.41
0.0
1.0
—
2.84
—
0
10
0
17
0.00
0.41
0.0
1.0
—
—
—
0
0
0
17
0.00
0.41
0.0
1.7
—
233.84
—
0
17
14
106
1.35
0.40
4.1
7.2
47.55
59.79
ng/l
0.68
14
101
5
35
1.44
0.39
7.8
18.8
1.26
1.17
mmol/l
—
5
30
5
36
1.40
0.38
1.0
4.6
—
—
—
0
0
9
69
1.32
0.38
3.9
1.9
—
—
—
0
0
12
90
1.36
0.37
1.8
2.7
88.61
4802.00
u/l
—
7
39
35
303
1.19
0.36
5.2
3.3
—
—
—
0
0
6
45
1.34
0.34
1.2
1.2
—
—
—
0
0
44
491
0.86
0.33
1.3
1.6
0.75
1.59
u/ml
0.86
11
100
6
46
1.31
0.33
1.2
1.2
—
—
—
0
0
16
128
1.27
0.33
1.7
1.7
—
—
—
0
0
10
131
0.75
0.32
1.2
1.3
—
—
—
0
0
7
57
1.24
0.29
1.4
1.3
—
—
—
0
0
7
57
1.24
0.29
1.7
1.2
—
—
—
0
0
49
445
1.14
0.29
2.3
2.3
—
—
—
0
0
38
340
1.15
0.27
2.8
2.9
—
—
—
0
0
19
161
1.20
0.25
2.7
2.6
418.74
361.56
nmol/l
0.43
19
151
143
1393
1.13
0.23
35.1
14.7
334.99
335.83
g/l
0.55
143
1384
13
107
1.23
0.22
1.5
1.3
36.80
145.57
iu/ml
—
5
42
5
41
1.23
0.22
1.0
4.3
126.00
332.71
e6/l
—
5
31
5
41
1.23
0.22
1.0
4.2
1.40
3.27
e6/l
—
5
30
42
457
0.89
0.22
1.5
1.7
2.17
1.97
g/l
0.35
30
249
0
11
0.00
0.21
0.0
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
3.4
—
2.65
—
0
11
0
10
0.00
0.21
0.0
1.7
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
369.25
—
0
12
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
2.8
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
6
49
1.23
0.20
1.2
1.5
—
—
—
0
0
13
154
0.83
0.20
1.0
1.3
44.35
9.55
u/ml
—
6
62
6
51
1.18
0.19
1.3
1.3
—
—
—
0
0
6
53
1.14
0.19
1.0
1.6
—
—
—
0
0
33
356
0.91
0.15
1.6
1.7
—
—
—
0
0
14
159
0.87
0.13
1.6
1.5
—
—
—
0
0
5
44
1.14
0.10
1.0
1.1
—
—
—
0
0
5
44
1.14
0.10
1.2
3.9
466.60
469.05
mg/l
—
5
44
5
46
1.09
0.09
2.4
1.4
—
—
—
0
0
7
63
1.12
0.08
1.0
1.0
—
—
—
0
0
7
67
1.05
0.08
6.3
5.7
—
—
—
0
0
6
70
0.85
0.08
3.8
1.7
—
—
—
0
0
9
86
1.05
0.07
2.0
1.6
—
—
—
0
0
14
128
1.10
0.07
1.6
1.5
—
—
—
0
0
33
316
1.05
0.06
2.2
1.7
95.06
97.61
pmol/l
0.13
23
159
31
298
1.05
0.05
4.8
3.1
1.01
1.02
kg/l
—
5
39
33
318
1.05
0.04
2.2
1.8
—
—
—
0
0
15
160
0.93
0.04
1.6
1.5
—
—
—
0
0
15
160
0.93
0.04
2.1
1.5
—
—
—
0
0
14
149
0.93
0.03
1.6
1.5
—
—
—
0
0
15
159
0.94
0.03
1.6
1.5
—
—
—
0
0
11
117
0.94
0.02
1.6
1.5
—
—
—
0
0
19
197
0.96
0.01
1.5
1.3
—
—
—
0
0
10
103
0.97
0.00
1.2
1.3
—
—
—
0
0
12
122
0.98
0.00
1.6
1.8
—
—
—
0
0
15
152
0.99
0.00
1.4
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
170.00
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
11.95
—
0
5
5
57
0.87
-0.00
1.4
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
8.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
93
0.97
-0.00
1.9
2.3
—
32.40
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
49
1.02
-0.00
2.6
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
1642.14
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
5.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.5
—
18.50
—
0
8
0
8
0.00
-0.00
0.0
1.0
—
2.36
—
0
8
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0

Mortality – FinRegistry

↥

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

↥

Index endpoint: Q17_CONGENITAL_AORTIC_VALVE_STENOSIS – Congenital aortic valve stenosis

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).