Bicuspidal aortic valve syndrome

Q17_BICUSP_AORTIC_VALVE

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 Q23.11
  • Cause of death: ICD-10 Q23.11

2 out of 7 registries used, show all original rules.

1421

4. Check minimum number of events

None

1421

5. Include endpoints

None

1421

6. Filter based on genotype QC (FinnGen only)

1356

Control definitions (FinnGen only)

Control exclude
Q17_CONGEN_MALFO_CIRCULATO_SYSTEM

Extra metadata

First used in FinnGen datafreeze
DF12

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 1356 421 935
Unadjusted period prevalence (%) 0.34 0.15 0.43
Median age at first event (years) 54.91 53.16 55.69

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1421
Matched controls
14210
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
WX872
NOMESCO Finland
Intensive care
12.9
315.1
340
337
B01AA03
ATC
warfarin; systemic
12.0
307.7
713
1098
Q23.11
ICD-10 Finland
Bicuspid aortic valve
+∞
307.7
1421
*
I35.0
ICD-10 Finland
Aortic (valve) stenosis
42.0
307.7
613
252
FMD00
NOMESCO Finland
Replacement of aortic valve using mechanical prosthesis
108.9
307.7
266
30
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
9.3
307.7
717
1409
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
18.6
307.7
514
421
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
62.6
307.7
418
94
I35.2
ICD-10 Finland
Aortic (valve) stenosis with insufficiency
65.7
307.7
426
92
I71.2
ICD-10 Finland
Thoracic aortic aneurysm, without mention of rupture
53.1
307.7
525
155
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
45.3
307.7
668
273
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
29.1
307.7
457
228
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
11.2
307.7
919
2004
FMD10
NOMESCO Finland
Replacement of aortic valve using biological prosthesis
60.9
307.7
195
37
I71.9
ICD-10 Finland
Aortic aneurysm of unspecified site, without mention of rupture
50.4
303.5
177
40
K83
ICPC
Heart valve disease NOS
53.9
297.6
171
36
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
5.7
226.2
654
1862
PD5BD
NOMESCO Finland
Extensive CT of aorta
26.2
222.2
157
67
FCA60
NOMESCO Finland
Resection of aortic root and ascending aorta with reimplantation of coronary arteries and use of composite graft with mechanical valve prosthesis
103.2
220.5
114
12
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
5.4
192.2
521
1378
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
6.9
180.5
322
575
PC1BD
NOMESCO Finland
Extensive CT of thoracic aorta
65.3
155.9
86
14
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
15.4
155.5
140
100
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
6.9
146.7
253
432
C07AB07
ATC
bisoprolol; oral
4.1
144.9
907
4281
Q25.1
ICD-10 Finland
Coarctation of aorta
+∞
132.4
125
*
AB1
HP
AVR mechanical
55.7
121.5
69
13
FCA50
NOMESCO Finland
Resection and reconstruction of ascending aorta using tube graft
181.9
113.2
117
7
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.3
106.8
859
4458
PD5AD
NOMESCO Finland
CT of aorta
10.3
89.6
103
107
TFP00
NOMESCO Finland
Temporary use of transvenous or epicardial pacemaker
17.7
86.4
71
42
B01AB05
ATC
enoxaparin; parenteral
3.0
85.2
563
2530
Q23.0
ICD-10 Finland
Congenital stenosis of aortic valve
+∞
82.1
78
*
K84
ICPC
Heart disease other
8.8
79.6
103
125
XF640, ,
NOMESCO Finland
9.0
79.3
101
120
Q23.10
ICD-10 Finland
Congenital insufficiency of aortic valve
+∞
75.7
72
*
Z95.3
ICD-10 Finland
Presence of xenogenic heart valve
38.7
72.9
45
12
I48
ICD-10 Finland
Atrial fibrillation and flutter
3.2
71.7
362
1377
FME20
NOMESCO Finland
Transvenous aortic valve replacement via femoral artery
17.6
68.1
56
33
I97.0
ICD-10 Finland
Postcardiotomy syndrome
32.4
67.8
44
14
TFP20
NOMESCO Finland
Cardiodefibrillation
4.4
67.1
185
468
PD5CG
NOMESCO Finland
Extensive MRI examination of thoracal and abdominal aortta with high intensity magnet
96.2
66.6
73
8
I35.9
ICD-10 Finland
Aortic valve disorder, unspecified
23.6
66.3
48
21
XF404
NOMESCO Finland
Ambulatory ECG
4.1
66.2
206
570
I33.0
ICD-10 Finland
Acute and subacute infective endocarditis
18.6
64.9
52
29
I35.8
ICD-10 Finland
Other aortic valve disorders
29.5
64.3
43
15
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
5.6
64.0
128
247
FM1CG
NOMESCO Finland
Extensive examination of hear with high intensity magnet
27.7
63.0
43
16
ZXE20
NOMESCO Finland
More than three and less than five hours
3.2
62.2
291
1050
ZXE30
NOMESCO Finland
More than five and less than seven hours
4.9
57.5
133
291
XF402
NOMESCO Finland
ECG with work load test
3.5
56.9
227
740
FM1DG
NOMESCO Finland
Very extensive MRI examination of heart with high intesity magnet
8.5
56.8
75
93
FC1AC
NOMESCO Finland
Angiography of thoracal aortta
24.2
55.8
40
17
WW502
NOMESCO Finland
Autotransfusion
16.7
55.8
47
29
XFE00
NOMESCO Finland
Epicardial ultrasonography
8.2
54.9
74
94
Z95.8
ICD-10 Finland
Presence of other cardiac and vascular implants and grafts
23.6
53.8
39
17
TPH07
NOMESCO Finland
Cathetrisation of artery
3.3
53.8
239
832
AN1
HP
Coronary angiography
3.4
51.8
213
706
I44.2
ICD-10 Finland
Atrioventricular block, complete
6.9
49.6
78
118
K78
ICPC
Atrial fibrillation/flutter
4.1
49.5
144
377
FN1CD
NOMESCO Finland
Very extensive CT of coronary arteries
16.2
47.9
41
26
201
Kela drug reimbursment
Chronic cardiac insufficiency
4.8
47.9
113
251
C03CA01
ATC
furosemide; systemic
2.5
47.8
381
1800
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
5.8
45.9
87
159
WX408
NOMESCO Finland
General anesthesy, balanced
2.3
44.4
458
2416
C01BD01
ATC
amiodarone; systemic
5.8
42.1
79
143
AJ1
HP
Reconstruction of the aortic base, eg composite graft, incl. valve saving operation
79.3
41.1
46
6
Q21.10
ICD-10 Finland
Persistent ostium secundum
+∞
39.8
38
*
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
8.6
39.6
51
61
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
3.4
39.6
155
495
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
4.4
38.9
102
246
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
3.2
37.5
158
528
AB2
HP
AVR bio, stent
133.6
36.9
39
*
PD5BG
NOMESCO Finland
MRI examination of thoracal and abdominal aortta with high intensity magnet
100.2
35.9
39
*
J01CA04
ATC
amoxicillin; systemic
2.6
35.5
1227
10034
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.0
35.4
676
4427
K99
ICPC
Cardiovascular disease other
5.8
35.1
65
116
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
3.7
34.9
119
347
XF400
NOMESCO Finland
ECG with 12 standard connections
2.5
34.8
265
1207
FCA75
NOMESCO Finland
Valve-sparing repair of aortic root (David, Yacoub)
179.3
33.9
35
*
Q21.08
ICD-10 Finland
Other specifed ventricular septal defect
+∞
32.4
31
*
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
4.3
32.4
85
205
R01.1
ICD-10 Finland
Cardiac murmur, unspecified
5.6
31.2
60
111
74719
ICD-8 Finland
Other congenital anomalies of circulatory system, Coarctation of aorta
319.6
30.9
31
*
AJ2
HP
Reconstruction of the ascending aorta
87.1
30.9
34
*
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
3.2
30.8
128
423
WX402
NOMESCO Finland
General anaesthesia
2.1
30.6
361
1966
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
4.5
30.5
76
176
7471A
ICD-9 Finland
Other congenital anomalies of circulatory system, Coarctation of aorta[COARCTATIO AORTAE]
+∞
30.3
29
*
FCA70
NOMESCO Finland
Resection of aortic root and ascending aorta with reimplantation of coronary arteries and use of biological valve prosthesis and tube graft
46.1
29.7
36
8
I50.9
ICD-10 Finland
Heart failure, unspecified
2.7
29.5
169
668
ZXD10
NOMESCO Finland
Scheduled procedure
1.9
29.4
544
3464
PD5DG
NOMESCO Finland
Very extensive MRI examination of thoracal and abdominal aortta with high intensity magnet
81.9
28.9
32
*
R4110
NOMESCO Finland
Physiotherapy
2.0
28.8
424
2497
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
3.7
28.3
93
264
C09AA05
ATC
ramipril; oral
2.0
27.5
357
2005
FPE20
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with atrial and ventricular electrodes
4.2
27.2
73
179
Q21.09
ICD-10 Finland
Ventricular septal defect NOS
+∞
27.2
26
*
C03DA01
ATC
spironolactone; oral
2.6
26.4
172
723
Q21.11
ICD-10 Finland
Paten or persistent foramen ovale
+∞
26.1
25
*
WZC30
NOMESCO Finland
Teaching
2.2
25.7
258
1310
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.9
25.6
457
2849
FM2CE, ,
NOMESCO Finland
9.6
25.4
30
32
Q25.0
ICD-10 Finland
Patent ductus arteriosus
+∞
25.1
24
*
Q21.00
ICD-10 Finland
Multiple ventricular septal defect
+∞
25.1
24
*
O99.4
ICD-10 Finland
Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium
39.6
24.9
31
8
I35
ICD-10 Finland
Nonrheumatic aortic valve disorders
57.1
24.1
28
5
PD5CD
NOMESCO Finland
Very extensive CT angiography of aorta
24.1
23.5
33
14
I11.9
ICD-10 Finland
Hypertensive heart disease without (congestive) heart failure
3.7
23.4
76
214
FC1BC
NOMESCO Finland
Extensive angiography of thoracal aortta
29.6
21.9
29
10
I71.00
ICD-10 Finland
Dissecting aneurysm of aorta (ruptured) [any part]
25.5
21.8
30
12
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.8
20.7
405
2568
WX892
NOMESCO Finland
Monitored bed care
2.6
20.6
131
543
Z95.4
ICD-10 Finland
Presence of other heart-valve replacement
27.5
20.1
27
10
FEB10
NOMESCO Finland
Decompression and drainage of pericardium
19.1
20.0
30
16
61
HP
Catheterization and pressure measurement of the left side of the heart
6.2
19.4
33
54
ZXE40
NOMESCO Finland
More than seven and less than nine hours
4.3
19.4
50
119
21
HP
Aortic Valve Replacement (AVR)
34.8
18.9
24
7
H53.1
ICD-10 Finland
Subjective visual disturbances
2.7
18.8
105
408
FMD40
NOMESCO Finland
Replacement of aortic root using pulmonary autograft and reimplantation of coronary arteries (Ross)
+∞
18.8
18
*
Z2221
NOMESCO Finland
Medical doctor
1.8
18.6
373
2373
XF600
NOMESCO Finland
Bloodpressure measurement
2.7
18.5
107
423
FNC10
NOMESCO Finland
Aorto-coronary venous bypass with single distal anastomosis
5.5
18.1
35
65
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
2.8
18.0
94
353
C07AB02
ATC
metoprolol; systemic
2.0
17.9
227
1246
I47.1
ICD-10 Finland
Supraventricular tachycardia
3.2
17.7
71
229
K22
ICPC
Risk factor cardiovascular disease
2.8
17.7
90
333
A40.8
ICD-10 Finland
Other streptococcal sepsis
7.1
17.4
26
37
C09CA01
ATC
losartan; oral
1.8
17.3
339
2137
C10AA05
ATC
atorvastatin; oral
1.6
17.2
539
3850
ZXE00
NOMESCO Finland
One hour or less
1.7
17.2
515
3639
G45.3
ICD-10 Finland
Amaurosis fugax
4.9
17.1
38
80
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.6
17.0
101
405
N02BE01
ATC
paracetamol; systemic, rectal
1.9
16.9
1201
10543
PC1AD
NOMESCO Finland
CT of thoracic aorta
22.2
16.9
24
11
C01AA05
ATC
digoxin; systemic
2.9
16.8
80
285
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.6
16.8
99
395
31
HP
Congenital heart failure surgery
+∞
16.7
16
*
TFP34
NOMESCO Finland
Electrophysiological investigation
3.3
16.5
62
192
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
2.7
16.4
90
346
AA1AD
NOMESCO Finland
CT of head and brain
1.7
16.3
338
2161
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.8
16.2
268
1602
FM1AD
NOMESCO Finland
CT of heart
30.4
16.1
21
7
FMC20
NOMESCO Finland
Suture of leaflet of aortic valve
+∞
15.7
15
*
Q25.40
ICD-10 Finland
Aortic hypoplasia
+∞
15.7
15
*
PD5CM
NOMESCO Finland
Extensive MRI examination of thoracal and abdominal aorta with 3 Tesla magnet
+∞
15.7
15
*
K29
ICPC
Cardiovascular sympt/complt other
3.2
15.5
63
205
ZXE50
NOMESCO Finland
More than nine and less than 12 hours
5.1
15.3
32
64
I50.1
ICD-10 Finland
Left ventricular failure
3.0
15.2
68
234
R06.0
ICD-10 Finland
Dyspnoea
1.7
15.2
334
2165
R55
ICD-10 Finland
Syncope and collapse
2.1
15.0
144
712
R50.9
ICD-10 Finland
Fever, unspecified
1.9
14.9
226
1313
207
Kela drug reimbursment
Chronic arrhythmias
2.0
14.7
178
958
I71.09
ICD-10 Finland
Aortic dissection [regardless of location]
21.3
14.7
21
10
74673
ICD-8 Finland
Congenital anomalies of heart, Stenosis valvulae aortae
+∞
14.6
14
*
Q23.1
ICD-10 Finland
Congenital insufficiency of aortic valve
+∞
14.6
14
*
R07.4
ICD-10 Finland
Chest pain, unspecified
1.7
14.4
368
2477
C09AA04
ATC
perindopril; oral
2.8
14.3
73
271
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
3.8
14.0
42
112
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
2.4
14.0
94
400
5513
FHL
Coarctation resection, plastic or bypass
+∞
13.6
13
*
7463A
ICD-9 Finland
Other congenital anomalies of heart, Congenital stenosis of aortic valve[STENOSIS VALVULAE AORTAE CONGENITA]
+∞
13.6
13
*
C08CA01
ATC
amlodipine; oral
1.6
12.8
452
3271
I10
ICD-10 Finland
Essential (primary) hypertension
1.5
12.7
721
5774
FFM10
NOMESCO Finland
Occlusion or excision of atrial appendage externally with a closing device
15.6
12.6
20
13
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
12.5
299
1968
Q21.0
ICD-10 Finland
Ventricular septal defect
+∞
12.5
12
*
Q23.9
ICD-10 Finland
Congenital malformation of aortic and mitral valves, unspecified
+∞
12.5
12
*
I49.3
ICD-10 Finland
Ventricular premature depolarization
2.2
12.5
105
492
I38
ICD-10 Finland
Endocarditis, valve unspecified
20.2
12.5
18
9
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
2.3
12.2
93
419
I71.1
ICD-10 Finland
Thoracic aortic aneurysm, ruptured
16.6
11.7
18
11
TPH04
NOMESCO Finland
Cathetrisation of vein
1.6
11.6
279
1838
I33.9
ICD-10 Finland
Acute endocarditis, unspecified
23.1
11.6
16
7
I50.0
ICD-10 Finland
Congestive heart failure
2.5
11.6
74
308
R42
ICD-10 Finland
Dizziness and giddiness
1.7
11.5
244
1556
Q24.4
ICD-10 Finland
Congenital subaortic stenosis
+∞
11.5
11
*
Q25.48
ICD-10 Finland
Other congenital malformations of the aorta
+∞
11.5
11
*
ZXD05
NOMESCO Finland
Urgent procedure
1.6
11.5
387
2761
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
2.3
11.2
87
395
FM1DE, ,
SPAT
12.8
11.1
19
15
GD1LA
NOMESCO Finland
GD
4.3
11.0
28
66
I31.3
ICD-10 Finland
Pericardial effusion (noninflammatory)
14.0
11.0
18
13
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
1.9
11.0
152
855
G45.0
ICD-10 Finland
Vertebro-basilar artery syndrome
3.6
10.9
36
103
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
2.8
10.8
52
187
I34.1
ICD-10 Finland
Mitral (valve) prolapse
3.0
10.8
46
155
250, ,
Kela drug reimbursment
4.6
10.7
25
55
74639
ICD-8 Finland
Congenital anomalies of heart, Defectus septi ventriculorum
60.5
10.6
12
*
FCB40
NOMESCO Finland
Resection and reconstruction of aortic arch using tube graft
60.5
10.6
12
*
SPAT1249
SPAT
Treatment-related counselling outside office
1.5
10.6
475
3586
Z50.0
ICD-10 Finland
Cardiac rehabilitation
5.3
10.6
21
40
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
3.8
10.5
31
82
FMC10
NOMESCO Finland
Reduction of leaflet of aortic valve
110.8
10.4
11
*
FXA20
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia and circulatory arrest at concurrent surgical procedure
110.8
10.4
11
*
Q25.3
ICD-10 Finland
Stenosis of aorta
+∞
10.4
10
*
FDJ42
NOMESCO Finland
Percutaneous transluminal angioplasty of thoracic aorta in coarctation
+∞
10.4
10
*
211
HP
AVR mechanical
32.8
10.3
13
*
WZC00
NOMESCO Finland
Treatment plan or consultation
1.5
10.2
466
3526
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.7
10.0
209
1324
Z71.8
ICD-10 Finland
Other specified counselling
1.5
9.8
385
2822
TFC10
NOMESCO Finland
Catheterisation of left atrium or ventricle
4.4
9.8
24
55
FPD10
NOMESCO Finland
Surgical ablation of atrial fibrillation
20.2
9.8
14
7
5253
FHL
Cardiac lung machine
10.7
9.8
18
17
K80
ICPC
Cardiac arrhythmia NOS
2.1
9.8
95
472
FMC96
NOMESCO Finland
Other operation on aortic valve for insufficiency
55.4
9.7
11
*
GAE10
NOMESCO Finland
Closure of previous incision of chest wall
55.4
9.7
11
*
C09CA06
ATC
candesartan; oral
1.6
9.6
288
1993
Q22.1
ICD-10 Finland
Congenital pulmonary valve stenosis
+∞
9.4
9
*
FDJ00
NOMESCO Finland
End to end reconstruction of aorta for coarctation
+∞
9.4
9
*
7463D
ICD-9 Finland
Other congenital anomalies of heart, Congenital stenosis of aortic valve[BIKUSPINEN AORTALÄPPÄ]
+∞
9.4
9
*
Q32.11
ICD-10 Finland
Congenital tracheo-esophageal fissure
+∞
9.4
9
*
FWD00
NOMESCO Finland
Reoperation for superficial haemorrhage in surgery of heart and major thoracic vessels
8.1
9.3
20
25
WX704
NOMESCO Finland
Intubation
2.0
9.1
107
569
I44.7
ICD-10 Finland
Left bundle-branch block, unspecified
4.3
9.1
23
54
GAA10
NOMESCO Finland
Intercostal insertion of pleural drainage tube
3.5
9.1
30
86
FP4B5
NOMESCO Finland
ECG, prolonged recording (24 h)
3.7
9.0
28
77
62
HP
Catheterization and pressure measurement of the right side of the heart
12.6
8.9
15
12
C10AX09
ATC
ezetimibe; oral
1.6
8.8
208
1359
I42.0
ICD-10 Finland
Dilated cardiomyopathy
2.9
8.7
40
141
Q96.0
ICD-10 Finland
Karyotype 45,X
50.3
8.7
10
*
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
2.7
8.6
46
176
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.8
8.6
127
729
XF620
NOMESCO Finland
Examination of circulation with color method
11.6
8.6
15
13
I49.1
ICD-10 Finland
Atrial premature depolarization
2.6
8.5
50
200
I49.4
ICD-10 Finland
Other and unspecified premature depolarization
2.6
8.5
50
200
FXD00
NOMESCO Finland
Use of ECHLA without concurrent surgical procedure
27.7
8.5
11
*
PA1BD
NOMESCO Finland
Extensive CT of aortic arch and branches
27.7
8.5
11
*
ZSF00
NOMESCO Finland
Procedure related to previous procedure classified in chapter F
20.2
8.5
12
6
GD1AD
NOMESCO Finland
Thorax CT examination
2.1
8.4
78
381
TFP44
NOMESCO Finland
Ablation treatment of typical atrial flutter
4.5
8.4
20
45
FCA96
NOMESCO Finland
Other repair of ascending aorta
+∞
8.3
8
*
FMA20
NOMESCO Finland
Plastic repair of aortic valve for stenosis
+∞
8.3
8
*
C07AA07
ATC
sotalol; systemic
2.8
8.3
40
145
ZXE10
NOMESCO Finland
More than one and less than three hours
1.4
8.2
422
3239
I48.1
ICD-10 Finland
Persistent atrial fibrillation
2.6
8.2
45
174
Z01.2
ICD-10 Finland
Dental examination
1.4
8.2
594
4839
SPAT1079
SPAT
Echocardiography
4.2
8.2
21
50
81
HP
Angiography of the heart and coronary arteries
2.2
8.2
64
292
N02AX02
ATC
tramadol; systemic, rectal
1.4
8.0
530
4252
PH1AC
NOMESCO Finland
Flebography of over extremity with X-ray
3.7
7.9
24
65
A02BC02
ATC
pantoprazole; systemic
1.4
7.9
827
7141
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.7
7.9
163
1029
N02AJ06
ATC
codeine and paracetamol; systemic
1.4
7.8
547
4422
WX002
NOMESCO Finland
Sedation and analgesia
1.6
7.8
220
1496
FM1AT
NOMESCO Finland
Percutaneous implantation of aortic valve endoprosthesis
45.2
7.7
9
*
Q96.9
ICD-10 Finland
Turner syndrome, unspecified
45.2
7.7
9
*
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.7
7.7
147
908
I71.6
ICD-10 Finland
Thoracoabdominal aortic aneurysm, without mention of rupture
18.5
7.6
11
6
R04.0
ICD-10 Finland
Epistaxis
1.9
7.6
89
475
I48.2
ICD-10 Finland
Chronic atrial fibrillation
2.5
7.6
47
194
SAA02
NOMESCO Finland
Basic examination of mouth
1.4
7.5
906
7975
FPE30
NOMESCO Finland
Replacement of transvenous cardiac pacemaker pulse generator
4.4
7.4
18
41
RD211, ,
NOMESCO Finland
2.2
7.4
58
266
I37.0
ICD-10 Finland
Pulmonary valve stenosis
+∞
7.3
7
*
ABX
HP
Other aortic valve operation
+∞
7.3
7
*
FHB50
NOMESCO Finland
Transatrial closure of VSD using patch
+∞
7.3
7
*
FM1CD
NOMESCO Finland
Very extensive CT of heart
9.4
7.3
14
15
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
2.8
7.2
36
133
FM1EE, ,
SPAT
3.7
7.2
22
60
AQ1
HP
Conventional electrophysiological examination
4.0
7.2
20
51
FCC45
NOMESCO Finland
Percutaneous insertion of stent into descending aorta
20.1
7.1
10
5
I72.1
ICD-10 Finland
Aneurysm and dissection of artery of upper extremity
20.1
7.1
10
5
M01AE01
ATC
ibuprofen; systemic, rectal
0.7
7.0
1066
11502
I44.0
ICD-10 Finland
Atrioventricular block, first degree
3.5
7.0
23
66
AP1
HP
Catheterization of the left side of the heart
3.4
6.8
24
72
I34.9
ICD-10 Finland
Nonrheumatic mitral valve disorder, unspecified
8.3
6.8
14
17
FN1AD
NOMESCO Finland
CT of coronary arteries
2.9
6.8
30
104
TFC99
NOMESCO Finland
Catheterisation of heart with other procedure
16.8
6.7
10
6
SPAT1263
SPAT
Sampling
1.4
6.7
489
3954
AA5BD
NOMESCO Finland
CT of cerebral ischaemia
3.0
6.7
29
99
FXF00
NOMESCO Finland
Decannulation after ECHLA or ECLA
22.6
6.7
9
*
3A422, ,
NOMESCO Finland
22.6
6.7
9
*
I48.3
ICD-10 Finland
Typical atrial flutter
4.0
6.6
18
45
FKB10
NOMESCO Finland
Annuloplasty of mitral valve for insufficiency using ring
4.0
6.6
18
45
J01DB01
ATC
cefalexin; oral
1.4
6.6
1099
10062
I71.01
ICD-10 Finland
Aneurysm of the descending aorta
12.3
6.6
11
9
R00.2
ICD-10 Finland
Palpitations
1.8
6.5
90
506
WX882
NOMESCO Finland
High dependency care
2.4
6.4
43
184
474, ,
NOMESCO Finland
70.2
6.4
7
*
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
2.3
6.4
47
210
SAA03
NOMESCO Finland
Extended examination of mouth
1.3
6.3
523
4303
FXZ00
NOMESCO Finland
Off-pump cardiac operation
6.0
6.3
16
27
Z95.1
ICD-10 Finland
Presence of aortocoronary bypass graft
2.2
6.3
50
231
I34.2
ICD-10 Finland
Nonrheumatic mitral (valve) stenosis
18.1
6.3
9
5
FLE96
NOMESCO Finland
Other repair of outlet obstruction of left ventricle
+∞
6.3
6
*
PD5DM
NOMESCO Finland
Very extensive MRI examination of thoracal and abdominal aorta with 3 Tesla magnet
+∞
6.3
6
*
Q21.19
ICD-10 Finland
Atrial septal defect NOS
+∞
6.3
6
*
74679
ICD-8 Finland
Congenital anomalies of heart, Aliae malformationes valvulae aortae sive ventriculi sinistri
+∞
6.3
6
*
FFC00
NOMESCO Finland
Suture of ostium secundum type ASD
+∞
6.3
6
*
K73
ICPC
Congenital anomaly cardiovascular
+∞
6.3
6
*
I47.2
ICD-10 Finland
Ventricular tachycardia
2.7
6.0
30
111
I42.9
ICD-10 Finland
Cardiomyopathy, unspecified
3.4
6.0
21
63

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
953
2735
8.54
307.65
4.0
3.1
783.39
1197.27
ng/l
2.79
885
2301
595
1686
5.35
203.72
3.9
2.5
30.52
29.81
s
1.83
583
1642
426
927
6.13
196.12
2.5
2.3
17.99
7.75
ug/l
9.55
415
839
998
4903
4.48
153.57
51.9
12.3
1.95
1.23
inr
50.90
335
1452
330
760
5.35
139.06
3.1
2.8
163.82
177.19
ng/l
0.25
310
681
481
2026
3.08
81.02
4.9
3.6
2034.72
570.02
ng/l
6.55
438
1528
1153
7950
3.39
74.34
6.0
3.5
—
—
—
0
0
58
33
18.28
71.73
10.8
6.2
—
—
—
0
0
53
28
19.62
67.77
9.5
6.3
—
—
—
0
0
614
3203
2.61
66.02
2.6
2.2
358.52
293.07
u/l
0.66
587
3029
841
5138
2.56
64.09
3.0
2.6
—
—
—
0
0
515
2648
2.48
54.94
2.4
2.5
—
—
—
0
0
42
22
19.64
53.78
7.6
6.8
—
—
—
0
0
966
6622
2.43
52.43
8.5
5.4
6.60
6.72
mmol/l
1.13
932
6220
676
4037
2.29
49.99
3.8
3.4
83.67
59.72
ng/l
0.66
478
2726
49
41
12.34
49.00
9.5
6.4
25.80
25.09
mmol/l
0.56
44
35
271
1084
2.85
47.34
7.8
9.3
7.80
8.92
mmol/l
2.56
263
1038
529
2914
2.30
46.71
5.4
4.4
—
—
—
0
0
377
1812
2.47
45.23
4.5
4.6
0.83
0.81
mmol/l
2.20
364
1730
587
3429
2.21
44.41
2.5
2.5
—
—
—
0
0
273
1160
2.68
42.07
16.5
9.6
97.55
95.96
%
6.21
266
1120
285
1275
2.55
39.31
16.2
9.1
5.19
5.13
kpa
0.68
278
1230
285
1275
2.55
39.31
16.2
9.1
14.13
12.54
kpa
3.93
277
1233
834
5755
2.09
39.13
6.0
6.8
15.03
12.26
umol/l
5.36
797
5504
1376
11897
5.94
38.64
23.9
15.1
139.35
139.69
mmol/l
6.95
1361
11613
144
447
3.47
38.46
4.2
3.0
22.66
21.91
s
0.79
134
407
283
1275
2.52
38.39
16.2
9.1
1.08
1.03
mmol/l
0.09
248
1030
1378
11943
6.08
38.22
23.6
15.1
4.01
3.98
mmol/l
3.68
1362
11637
191
741
2.82
34.74
15.1
11.3
95.42
94.26
%
2.74
191
735
480
2875
2.01
31.54
5.2
4.4
74.95
90.12
%
20.51
473
2820
321
1665
2.20
30.85
2.4
2.6
13.45
14.01
umol/l
0.47
308
1567
248
1183
2.33
29.02
3.1
3.5
1.64
1.75
%
0.93
237
1079
87
235
3.88
28.44
5.7
5.3
—
—
—
0
0
172
703
2.65
28.04
19.2
7.8
24.88
24.55
mmol/l
0.68
166
670
171
710
2.60
26.97
13.9
5.6
—
—
—
0
0
1331
11728
3.13
26.25
18.5
13.2
34.26
23.89
mg/l
19.46
1164
9110
292
1549
2.11
26.06
2.4
2.6
2.38
2.35
g/l
0.46
280
1449
160
659
2.61
25.61
5.2
4.2
120.44
131.67
g/l
7.25
154
644
276
1455
2.11
24.94
2.5
2.7
23.28
24.26
%
0.37
246
1259
1368
12309
3.99
24.80
18.7
12.1
—
—
—
0
0
504
3283
1.83
24.33
1.4
1.4
—
—
—
0
0
153
633
2.59
24.24
22.9
12.6
—
—
—
0
0
64
158
4.19
23.64
10.3
6.6
10.69
10.71
mg/l
0.01
57
146
673
4806
1.76
23.57
10.9
7.1
1.18
1.21
mmol/l
20.49
637
4438
1381
12577
4.48
23.01
22.3
15.0
80.46
78.74
umol/l
1.16
1381
12572
720
5266
1.74
22.97
10.8
7.7
1.18
1.21
mmol/l
18.71
628
4553
211
1039
2.21
22.54
11.8
10.5
—
—
—
0
0
1056
8660
1.85
22.29
7.4
7.7
75.91
80.49
u/l
3.06
1015
8227
116
450
2.72
20.84
8.5
5.0
—
—
—
0
0
561
3921
1.71
20.33
3.4
3.6
35.13
38.37
u/l
0.32
542
3730
274
1615
1.86
17.43
2.4
2.1
—
—
—
0
0
110
454
2.54
17.43
1.9
2.0
1.33
1.50
g/l
0.92
72
393
684
5219
1.60
16.46
11.0
9.8
0.00
0.00
e9/l
0.03
592
4258
387
2578
1.69
15.98
2.4
2.3
3.20
2.92
mg/l
1.16
356
2213
372
2472
1.68
15.42
2.9
1.9
1.20
1.10
mg/l
0.29
261
1863
103
445
2.42
14.80
3.2
2.1
1.83
2.30
ug/l
0.22
94
406
1174
10356
1.77
14.64
23.1
15.8
14.30
15.04
%
0.98
1160
10187
985
8338
1.59
14.09
4.0
3.9
10.68
10.48
mm/h
0.20
930
7761
195
1100
1.90
14.03
4.0
5.3
2.00
1.90
mmol/l
0.16
164
905
607
4628
1.54
13.86
3.0
2.8
217.07
147.53
ug/l
0.38
572
4314
605
4613
1.54
13.79
5.5
5.5
35.83
36.09
g/l
0.52
572
4336
1164
10294
1.72
13.75
4.5
4.2
1.93
2.13
mu/l
0.62
1082
9483
1404
13331
5.45
13.71
29.5
19.3
39.85
41.25
%
17.54
1342
12571
426
3011
1.59
13.51
5.4
3.7
—
—
—
0
0
1404
13341
5.38
13.48
28.5
19.1
234.47
247.19
e9/l
12.46
1381
13011
1404
13348
5.33
13.32
28.3
19.0
30.21
30.30
pg
1.32
1391
13186
1404
13348
5.33
13.32
28.3
19.0
90.44
90.43
fl
0.03
1391
13188
1404
13349
5.33
13.30
28.5
19.1
6.82
6.68
e9/l
1.83
1378
12977
1404
13350
5.32
13.27
28.4
19.1
4.44
4.63
e12/l
29.16
1377
12984
1404
13353
5.30
13.20
28.8
19.2
132.98
139.60
g/l
41.12
1391
13186
161
871
1.96
13.10
3.7
3.3
74.11
71.88
e9/l
0.29
121
664
1348
12591
2.37
12.20
11.3
10.0
28.63
29.74
u/l
1.43
1309
12229
966
8328
1.50
11.08
3.8
3.5
14.92
14.71
pmol/l
1.65
887
7609
1227
11200
1.70
10.59
4.4
3.8
1.32
1.36
mmol/l
1.03
1168
10415
398
2911
1.51
10.34
6.8
7.3
—
—
—
0
0
211
1330
1.69
10.30
1.2
1.3
—
—
—
0
0
98
498
2.04
9.51
2.7
4.0
0.70
0.66
%
0.70
98
498
403
2998
1.48
9.51
3.9
4.2
7.40
7.40
ph
0.55
85
576
39
130
3.06
9.32
2.9
2.4
32.77
33.12
pg
0.24
39
130
49
186
2.69
9.26
1.4
1.2
6.61
5.89
u/ml
0.09
31
87
1269
11785
1.72
9.06
5.4
4.6
2.68
2.80
mmol/l
5.57
1215
11003
1258
11656
1.69
9.06
4.8
4.3
4.48
4.65
mmol/l
8.04
1207
10953
1211
11115
1.61
9.05
4.2
4.2
5.89
5.95
mmol/l
0.85
1124
10260
75
353
2.19
8.89
20.9
7.5
1.29
1.25
mmol/l
0.25
69
307
1250
11594
1.65
8.57
4.8
4.2
1.37
1.38
mmol/l
0.44
1195
10828
788
6706
1.39
8.48
9.3
9.7
4.13
4.07
e9/l
0.32
705
5850
1161
10598
1.52
8.43
5.0
5.4
38.25
39.56
mmol/mol
5.94
1099
9944
400
3032
1.44
8.39
3.3
3.1
0.36
0.45
e6/l
0.51
311
2282
432
3325
1.43
8.33
3.3
3.2
344.48
79.06
e6/l
0.43
332
2554
702
5874
1.39
8.29
6.6
6.5
0.60
0.59
e9/l
0.77
626
5094
703
5884
1.39
8.29
6.5
6.5
0.04
0.04
e9/l
0.12
626
5099
722
6081
1.38
8.13
6.9
6.8
0.20
0.20
e9/l
0.14
648
5369
11
5
22.15
8.02
17.1
4.6
—
—
—
0
0
716
6038
1.37
7.92
6.6
6.6
1.73
2.02
e9/l
5.35
649
5366
663
5546
1.37
7.61
6.7
7.0
—
—
—
0
0
390
2992
1.42
7.53
3.2
3.1
—
—
—
0
0
306
2247
1.46
7.48
2.7
2.6
4.37
4.79
e6/l
0.21
272
2024
641
5344
1.36
7.47
6.8
6.7
0.71
0.68
%
0.73
608
5041
655
5513
1.35
7.03
6.7
6.7
3.07
2.93
%
0.67
619
5203
658
5543
1.35
7.02
7.0
7.0
9.09
8.71
%
2.83
623
5235
672
5696
1.34
6.80
6.8
6.7
26.36
28.83
%
7.67
639
5397
663
5624
1.34
6.61
6.7
6.5
58.06
56.18
%
3.97
630
5323
472
3834
1.35
6.21
3.8
3.7
40.68
72.35
e6/l
1.35
349
2729
778
6848
1.30
5.56
4.1
3.9
180.75
1358.33
e6/l
0.89
12
103
33
134
2.50
5.56
2.6
2.3
—
—
—
0
0
501
4190
1.30
5.16
1.8
2.0
—
—
—
0
0
25
93
2.72
5.02
1.2
1.4
6.23
6.47
mmol/l
0.26
25
86
427
3511
1.31
4.95
2.9
2.7
61.25
81.75
u/l
0.43
393
3294
24
89
2.73
4.85
6.4
3.5
—
—
—
0
0
247
1886
1.37
4.69
2.9
2.8
0.66
0.93
e6/l
1.41
157
1066
183
1333
1.43
4.58
1.8
1.7
—
—
—
0
0
26
106
2.48
4.39
1.6
1.5
2657.90
1818.74
e6/l
0.44
21
70
13
29
4.51
4.25
15.8
15.1
—
—
—
0
0
16
51
3.16
4.21
1.3
1.4
—
—
—
0
0
14
42
3.36
4.05
1.2
1.2
—
—
—
0
0
19
69
2.78
4.02
7.4
3.8
—
—
—
0
0
21
82
2.58
3.89
1.4
1.5
—
—
—
0
0
826
7507
1.24
3.82
4.0
3.9
—
—
—
0
0
7
8
8.79
3.77
1.0
1.0
—
—
—
0
0
268
2141
1.31
3.73
2.8
2.8
546.82
568.95
mosm/kgh2o
0.84
221
1843
30
142
2.14
3.66
2.0
2.8
0.83
0.87
nmol/l
0.13
24
103
8
13
6.18
3.50
1.8
1.2
—
—
—
0
0
22
94
2.36
3.42
1.6
1.4
—
—
—
0
0
122
872
1.44
3.41
3.5
3.0
—
—
—
0
0
112
793
1.45
3.30
3.6
4.3
1.23
1.22
mmol/l
0.04
100
698
22
96
2.31
3.27
1.5
1.4
97836.15
22132.61
e6/l
0.80
13
54
278
2270
1.28
3.26
1.4
1.5
20.72
20.25
nmol/l
0.22
249
1958
7
11
6.39
3.18
1.4
1.3
—
—
—
0
0
177
1374
1.33
3.02
1.7
1.5
—
—
—
0
0
11
31
3.57
2.99
1.8
2.3
—
—
—
0
0
53
330
1.63
2.83
1.1
1.1
—
—
—
0
0
66
434
1.55
2.82
2.9
3.2
—
—
—
0
0
16
65
2.48
2.79
1.2
1.2
1.10
1.06
ratio
—
6
23
50
309
1.64
2.76
1.6
1.6
—
—
—
0
0
335
2852
1.23
2.70
4.0
3.5
0.00
0.01
estimate
0.88
108
975
219
1785
1.27
2.60
3.1
3.0
1.69
1.47
e6/l
0.14
130
972
47
292
1.63
2.56
1.6
1.6
88.96
120.32
u/ml
0.92
12
52
38
223
1.72
2.56
2.5
2.1
—
—
—
0
0
354
3066
1.21
2.38
2.7
2.8
2336.90
5212.33
umol/l
1.11
325
2745
39
240
1.64
2.24
3.2
5.1
2.03
2.56
mmol/l
0.74
31
156
26
142
1.85
2.24
1.2
1.1
—
—
—
0
0
84
611
1.40
2.21
3.9
3.5
4.53
4.66
pmol/l
0.48
75
547
285
2447
1.21
2.09
3.7
3.2
—
—
—
0
0
5
10
5.01
2.07
1.0
1.0
—
—
—
0
0
5
10
5.01
2.07
1.0
1.0
—
—
—
0
0
21
379
0.55
2.05
1.2
1.3
88.87
220.50
miu/ml
—
10
169
48
318
1.53
2.05
1.2
1.4
282.91
265.11
u/ml
0.16
37
186
20
104
1.94
2.01
5.3
7.6
12.01
11.46
%
0.25
20
104
19
97
1.97
2.00
1.6
1.6
—
—
—
0
0
7
172
0.40
1.91
1.1
1.5
—
—
—
0
0
45
301
1.51
1.87
4.9
3.2
—
—
—
0
0
579
5316
1.15
1.84
4.6
4.4
0.00
0.00
estimate
0.50
122
1021
580
5331
1.15
1.81
3.6
3.2
0.00
0.00
estimate
0.50
126
1054
7
167
0.42
1.79
1.1
1.4
—
—
—
0
0
7
168
0.41
1.79
1.1
1.4
—
—
—
0
0
452
4088
1.15
1.76
1.9
1.9
95.03
95.38
pmol/l
0.06
258
2242
68
499
1.38
1.75
1.3
1.3
—
—
—
0
0
5
13
3.86
1.71
1.0
1.1
—
—
—
0
0
29
180
1.62
1.67
1.2
1.5
70.71
65.69
mmol/l
0.22
24
151
30
188
1.61
1.67
1.3
1.6
—
—
—
0
0
135
1100
1.25
1.66
2.6
2.6
0.21
0.22
g/l
1.31
130
1031
106
839
1.28
1.65
4.8
4.8
0.70
0.16
%
0.39
33
238
16
83
1.94
1.65
5.6
2.1
—
—
—
0
0
202
1723
1.20
1.60
1.6
1.7
1270.80
1173.71
nmol/l
0.84
161
1330
14
70
2.01
1.59
2.9
4.6
—
—
—
0
0
294
2594
1.17
1.58
2.9
2.7
—
—
—
0
0
0
42
0.00
1.52
0.0
1.0
—
16.92
—
0
27
13
65
2.01
1.49
3.0
2.9
1088.08
1198.68
u/ml
0.05
13
65
579
5376
1.13
1.48
3.6
3.3
0.00
0.00
estimate
0.50
120
953
163
1375
1.21
1.47
2.9
3.2
9.78
8.45
umol/l
0.35
149
1222
117
953
1.25
1.47
3.3
2.7
10.94
10.43
g/l
0.72
111
887
153
1286
1.21
1.43
1.4
1.4
—
—
—
0
0
29
431
0.67
1.37
2.3
3.4
—
—
—
0
0
58
436
1.34
1.34
2.1
1.6
—
—
—
0
0
23
144
1.61
1.32
2.3
2.9
—
—
—
0
0
5
18
2.78
1.28
1.4
1.3
—
—
—
0
0
10
48
2.09
1.28
1.0
1.1
—
—
—
0
0
175
1509
1.18
1.26
1.4
1.3
546.67
482.80
titre
0.17
39
300
108
889
1.23
1.26
4.7
4.7
0.23
0.14
%
0.33
35
296
47
347
1.37
1.24
1.3
1.1
—
—
—
0
0
15
85
1.77
1.23
1.1
1.1
—
—
—
0
0
47
348
1.36
1.22
1.2
1.1
—
—
—
0
0
35
247
1.43
1.19
3.9
4.2
—
—
—
0
0
113
942
1.22
1.18
4.6
4.7
0.95
0.95
%
0.00
40
350
0
34
0.00
1.16
0.0
3.0
—
—
—
0
0
103
853
1.22
1.15
4.5
4.5
0.76
0.68
%
0.18
34
291
23
150
1.54
1.14
1.0
1.2
—
—
—
0
0
375
3441
1.12
1.13
3.3
3.4
2.34
2.35
mmol/l
1.03
335
3075
14
80
1.76
1.13
22.9
32.8
136.44
132.66
ug/l
—
9
69
7
31
2.26
1.10
1.1
2.2
—
—
—
0
0
47
355
1.34
1.10
12.7
9.1
—
—
—
0
0
35
252
1.40
1.09
2.1
2.3
126.80
132.57
g/l
0.66
25
184
11
59
1.87
1.07
1.0
1.2
188.91
236.31
iu/ml
0.29
11
59
53
411
1.30
1.04
1.3
1.2
0.33
1.06
u/ml
—
8
32
340
3119
1.12
1.03
1.6
1.7
1.42
1.44
mmol/l
0.15
287
2653
199
1767
1.15
1.01
2.1
3.2
2.43
2.44
mmol/l
0.60
168
1562
23
155
1.49
1.01
2.1
2.4
—
—
—
0
0
107
904
1.20
1.01
2.9
3.7
—
—
—
0
0
18
115
1.57
0.99
2.8
2.7
—
—
—
0
0
101
850
1.20
0.99
6.7
4.6
7.42
7.41
ph
—
8
96
80
658
1.23
0.98
6.8
4.9
—
—
—
0
0
63
505
1.26
0.97
2.0
2.2
—
—
—
0
0
44
337
1.32
0.96
1.5
2.6
12374.25
3847.44
u/l
—
10
127
9
51
1.77
0.94
1.0
1.0
—
—
—
0
0
94
791
1.20
0.93
1.5
1.4
—
—
—
0
0
24
167
1.44
0.92
2.3
3.4
—
—
—
0
0
20
291
0.68
0.92
3.0
3.5
—
—
—
0
0
18
118
1.53
0.91
2.8
2.7
105.72
105.24
mmol/l
0.23
18
118
18
118
1.53
0.91
2.8
2.7
3.96
4.04
mmol/l
0.66
18
118
23
323
0.71
0.88
1.5
1.6
459.35
520.76
mg/l
0.73
23
306
12
72
1.67
0.85
1.2
1.3
1.39
1.51
g/l
1.35
12
72
156
1383
1.14
0.84
1.4
1.5
—
—
—
0
0
40
510
0.78
0.82
2.0
2.5
—
—
—
0
0
30
223
1.35
0.82
1.4
1.2
23.42
36.64
u/ml
—
5
18
6
32
1.88
0.82
1.2
2.1
—
—
—
0
0
8
47
1.71
0.80
1.0
1.0
—
—
—
0
0
52
640
0.81
0.80
1.8
2.5
—
—
—
0
0
6
33
1.82
0.79
1.2
1.4
—
—
—
0
0
5
100
0.50
0.77
1.0
1.1
—
—
—
0
0
0
28
0.00
0.76
0.0
1.5
—
77.47
—
0
23
13
197
0.66
0.75
1.5
1.4
—
—
—
0
0
34
262
1.31
0.75
1.7
1.7
11394.00
14816.43
e6/l
0.34
22
196
52
633
0.81
0.73
1.7
2.5
—
—
—
0
0
73
617
1.19
0.73
3.8
2.4
—
—
—
0
0
112
1274
0.87
0.73
1.6
1.6
—
—
—
0
0
53
642
0.82
0.72
2.1
2.5
—
—
—
0
0
5
26
1.93
0.70
1.8
1.1
—
—
—
0
0
5
26
1.93
0.70
1.8
1.1
—
—
—
0
0
5
26
1.93
0.70
1.8
1.1
—
—
—
0
0
21
286
0.73
0.70
2.2
2.3
90.85
99.12
ug/min
0.05
16
167
7
41
1.71
0.70
1.3
2.4
—
—
—
0
0
9
142
0.63
0.70
1.6
2.1
—
—
—
0
0
52
627
0.82
0.68
1.8
2.4
—
—
—
0
0
5
27
1.85
0.68
1.2
1.3
—
—
—
0
0
5
27
1.85
0.68
1.2
1.3
—
—
—
0
0
5
27
1.85
0.68
1.2
1.3
—
—
—
0
0
9
59
1.53
0.68
2.3
2.4
20.89
159.40
ug/l
—
9
51
7
119
0.59
0.67
10.7
15.1
716.86
811.65
nmol/l
—
7
114
60
711
0.84
0.66
1.3
1.2
—
—
—
0
0
7
44
1.59
0.65
5.1
3.0
—
—
—
0
0
74
635
1.17
0.64
1.2
1.2
—
—
—
0
0
5
29
1.73
0.64
1.8
1.9
—
—
—
0
0
18
129
1.40
0.63
1.1
1.3
—
—
nmol/l
—
0
0
327
3073
1.08
0.62
2.8
2.8
0.70
0.70
ug/l
0.01
194
1868
20
147
1.37
0.62
1.1
1.4
0.53
0.62
nmol/l
0.72
20
140
18
130
1.39
0.61
2.2
2.8
39.97
36.26
%
0.51
18
130
200
1840
1.10
0.61
1.5
1.6
—
—
—
0
0
25
191
1.31
0.61
1.2
1.4
—
—
—
0
0
544
5214
1.07
0.61
4.2
4.3
2.03
2.33
ug/l
0.67
488
4739
0
23
0.00
0.58
0.0
1.0
—
—
—
0
0
0
23
0.00
0.58
0.0
1.6
—
7.14
—
0
7
39
319
1.23
0.57
1.4
1.5
255.43
285.65
ug/g
0.33
21
190
8
54
1.48
0.57
1.3
1.2
139.69
193.94
mmol/24h
—
8
54
170
1559
1.10
0.56
1.7
1.7
—
—
—
0
0
13
90
1.45
0.55
1.4
1.5
1.03
1.01
g/l
0.08
13
90
78
887
0.87
0.54
1.5
1.4
—
—
—
0
0
12
82
1.47
0.54
1.8
1.6
3.27
3.64
mg/l
0.27
12
77
9
60
1.50
0.54
2.6
2.4
2.00
1.74
umol/l
—
9
55
27
213
1.27
0.54
3.0
3.9
826.87
1373.02
u/ml
0.16
27
202
31
249
1.25
0.54
1.1
1.1
—
—
—
0
0
51
599
0.85
0.54
1.8
2.6
—
—
—
0
0
89
1002
0.88
0.54
3.9
4.5
3.15
22.02
ug/l
1.60
72
834
22
283
0.77
0.53
1.2
1.6
3.55
3.73
mmol/l
0.61
22
265
13
91
1.43
0.53
1.4
1.3
6.62
2.00
u/ml
—
7
54
40
479
0.83
0.52
1.7
1.9
217.90
217.49
pmol/l
0.01
40
453
31
250
1.25
0.52
1.1
1.1
—
—
—
0
0
6
98
0.61
0.52
1.2
1.1
356.50
292.15
mg/l
—
6
88
457
4377
1.06
0.52
3.2
3.0
5.84
5.82
ph
0.05
35
405
14
100
1.40
0.52
1.1
1.2
—
—
—
0
0
34
278
1.23
0.51
1.1
1.2
—
—
—
0
0
22
281
0.78
0.51
1.7
1.7
323.06
944.57
e6/l
0.64
17
221
22
281
0.78
0.51
1.7
1.7
4.06
44.00
e6/l
1.12
17
212
19
145
1.31
0.49
1.1
1.4
—
0.35
nmol/l
—
0
10
11
155
0.71
0.48
1.4
1.3
—
—
—
0
0
28
226
1.24
0.48
2.3
2.8
16.20
16.72
%
0.31
11
125
10
68
1.47
0.47
1.1
1.1
—
—
—
0
0
47
402
1.17
0.46
1.7
1.7
—
—
—
0
0
39
459
0.85
0.44
1.0
1.1
—
—
—
0
0
10
69
1.45
0.44
1.1
1.0
—
—
—
0
0
8
57
1.41
0.42
1.3
1.4
—
—
—
0
0
0
16
0.00
0.41
0.0
1.4
—
19.71
—
0
7
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.4
—
26.86
—
0
7
27
222
1.22
0.41
3.0
4.3
—
—
—
0
0
13
172
0.75
0.41
2.7
3.7
2.27
1.38
%
0.40
13
159
8
60
1.34
0.40
1.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
5.5
—
—
—
0
0
67
598
1.13
0.39
1.1
1.1
—
—
—
0
0
49
428
1.15
0.39
2.4
2.5
—
—
—
0
0
22
178
1.24
0.39
5.0
3.9
—
—
—
0
0
99
1080
0.91
0.38
2.3
2.3
367.15
360.29
nmol/l
0.14
88
1009
221
2093
1.07
0.37
1.5
1.7
72527900.18
37500421.66
pmol/l
0.20
182
1784
27
226
1.20
0.36
4.4
3.8
—
—
—
0
0
13
168
0.77
0.35
1.8
1.6
—
—
—
0
0
98
1065
0.91
0.35
1.9
1.8
—
—
—
0
0
10
134
0.74
0.35
1.2
1.2
—
—
—
0
0
310
2974
1.05
0.34
3.1
3.0
—
—
—
0
0
6
44
1.37
0.34
1.7
1.6
—
—
—
0
0
40
349
1.15
0.34
1.4
1.3
—
1688.00
—
0
5
6
88
0.68
0.33
1.0
1.5
80.00
79.84
umol/l
—
6
88
333
3206
1.05
0.32
3.3
3.3
754.07
233.30
mg/l
0.83
229
2186
17
137
1.24
0.32
1.1
1.4
—
—
—
0
0
26
220
1.19
0.32
1.0
1.1
—
—
—
0
0
35
305
1.15
0.31
3.9
3.6
69.06
71.35
mg/l
0.02
25
240
35
305
1.15
0.31
3.9
3.6
33.30
34.31
mg/l
0.04
26
242
22
261
0.84
0.30
1.8
1.7
—
—
—
0
0
7
55
1.27
0.30
4.6
3.3
—
—
—
0
0
13
163
0.80
0.29
3.5
3.1
20.77
21.18
nmol/l
0.05
13
156
11
141
0.78
0.29
1.3
1.4
—
—
—
0
0
16
195
0.82
0.29
1.0
1.1
1.31
2.65
u/ml
—
8
96
449
4613
0.96
0.28
2.6
2.7
—
—
—
0
0
11
85
1.30
0.28
1.0
1.1
—
—
—
0
0
50
451
1.11
0.27
1.2
1.2
—
—
—
0
0
8
64
1.25
0.27
1.0
1.3
—
—
—
0
0
8
64
1.25
0.27
2.4
1.7
—
—
—
0
0
8
64
1.25
0.27
10.0
2.0
9.38
9.92
mmol/l
—
8
64
164
1724
0.94
0.27
1.3
1.3
1.79
11.45
u/ml
7.42
63
688
844
8316
1.04
0.27
3.2
3.3
47.92
52.16
u/l
1.12
795
7878
38
338
1.13
0.26
2.0
2.4
9.55
10.41
g/l
0.66
33
312
240
2307
1.05
0.26
2.0
1.9
—
—
—
0
0
76
703
1.09
0.26
1.2
1.2
87.46
158.66
iu/ml
1.44
31
267
5
74
0.67
0.26
1.2
1.2
—
—
—
0
0
32
282
1.14
0.25
2.0
1.4
—
—
—
0
0
21
179
1.18
0.25
1.4
1.4
—
—
—
0
0
137
1442
0.94
0.24
1.3
1.4
—
—
—
0
0
26
227
1.15
0.24
1.1
1.1
—
—
—
0
0
19
162
1.18
0.23
1.2
1.3
—
—
—
0
0
115
1089
1.06
0.22
2.3
2.6
32.77
83.06
u/l
0.62
98
956
11
88
1.25
0.22
1.5
1.9
—
—
—
0
0
25
219
1.14
0.22
2.0
3.6
4.02
4.15
e9/l
0.09
25
219
0
10
0.00
0.21
0.0
1.3
—
38.40
—
0
10
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
10
123
0.81
0.20
1.1
1.2
1.64
1.43
nmol/l
—
10
107
21
183
1.15
0.20
1.9
1.8
—
—
—
0
0
23
202
1.14
0.20
1.7
1.7
1.01
0.81
g/l
0.40
15
160
138
1442
0.95
0.20
2.0
2.3
13.28
13.52
nmol/l
0.15
127
1323
32
288
1.11
0.20
1.3
2.5
37.51
38.29
g/l
0.28
27
263
15
127
1.18
0.19
1.2
1.5
0.34
0.31
nmol/l
—
9
100
62
664
0.93
0.19
2.6
2.4
—
—
—
0
0
12
143
0.84
0.18
2.3
1.9
—
—
—
0
0
13
109
1.19
0.18
1.1
1.3
—
—
—
0
0
38
415
0.91
0.18
3.3
3.8
33.03
3424.00
u/ml
0.78
33
351
93
979
0.95
0.18
2.6
4.5
—
—
—
0
0
40
435
0.92
0.18
3.1
4.3
0.33
0.26
g/l
0.25
22
222
121
1264
0.95
0.18
1.4
1.4
—
—
—
0
0
14
119
1.18
0.17
1.4
1.3
7.77
6.56
g/l
—
9
85
14
119
1.18
0.17
1.4
1.3
2.29
2.79
g/l
—
9
85
14
119
1.18
0.17
1.4
1.3
—
—
—
0
0
14
119
1.18
0.17
1.4
1.3
0.37
0.39
g/l
—
9
83
7
61
1.15
0.17
4.0
3.0
—
—
—
0
0
249
2422
1.03
0.17
1.6
1.5
2.35
2.47
g/l
0.65
172
1508
154
1484
1.04
0.17
1.1
1.2
—
—
—
0
0
345
3376
1.03
0.16
3.5
3.9
7.62
9.56
mg/mmol
0.51
232
2256
22
246
0.89
0.16
1.0
1.1
1.23
1.10
u/ml
—
10
127
177
1828
0.96
0.16
1.2
1.3
39.74
31.14
iu/ml
0.37
51
565
25
225
1.11
0.16
2.3
4.0
57.48
55.94
%
0.27
25
225
8
71
1.13
0.16
1.1
1.1
—
—
—
0
0
6
80
0.75
0.15
1.7
1.6
—
—
—
0
0
106
1016
1.05
0.15
1.4
1.5
—
—
—
0
0
19
169
1.13
0.14
1.7
2.3
—
1546.67
—
0
6
20
179
1.12
0.14
1.0
1.1
16.63
4.74
u/ml
—
6
75
8
98
0.82
0.13
1.7
1.2
2.71
2.02
mmol/l
—
8
91
39
418
0.93
0.13
1.5
1.6
—
—
—
0
0
23
253
0.91
0.13
1.0
1.1
5.31
7.90
u/ml
0.37
12
147
18
161
1.12
0.13
1.2
1.4
155.93
171.31
pmol/l
0.34
18
161
88
915
0.96
0.12
1.5
1.5
—
—
—
0
0
13
114
1.14
0.12
1.9
2.7
1.32
2.00
g/24h
—
8
63
75
781
0.96
0.11
2.7
3.2
4.39
5.95
e9/l
0.91
63
665
30
279
1.08
0.11
1.1
1.1
1.38
3.91
u/ml
1.55
19
167
61
585
1.04
0.09
1.6
1.6
—
—
—
0
0
10
87
1.15
0.09
1.5
1.6
—
—
—
0
0
23
247
0.93
0.08
1.0
1.1
3.43
2.17
u/ml
0.15
11
140
15
136
1.10
0.08
2.3
4.2
—
—
—
0
0
6
58
1.03
0.08
1.0
1.4
180.33
464.94
u/l
—
6
52
5
62
0.81
0.08
1.0
1.3
—
—
—
0
0
5
64
0.78
0.08
4.6
4.0
1.75
1.42
ug/l
—
5
59
5
64
0.78
0.08
2.0
1.6
—
—
—
0
0
20
185
1.08
0.08
1.1
1.2
—
—
—
0
0
7
65
1.08
0.08
2.6
2.1
3.69
3.14
ug/l
—
7
59
22
205
1.07
0.08
3.2
2.7
—
—
—
0
0
8
75
1.07
0.07
2.1
2.8
41375.00
40150.73
ug/l
—
8
75
12
108
1.11
0.07
1.1
1.2
—
—
—
0
0
9
85
1.06
0.07
1.0
1.0
—
—
—
0
0
15
163
0.92
0.07
1.1
1.2
—
—
—
0
0
9
87
1.03
0.07
1.0
1.2
—
—
—
0
0
8
92
0.87
0.06
1.0
1.1
—
8.94
—
0
20
79
811
0.97
0.06
2.3
2.4
17.33
21.15
au/ml
—
10
56
28
295
0.95
0.06
1.2
1.2
—
—
—
0
0
145
1475
0.98
0.06
2.4
2.8
121.05
146.18
ug/g
0.38
116
1216
98
959
1.02
0.06
1.1
1.2
—
—
—
0
0
243
2406
1.01
0.05
4.3
3.4
1.02
1.02
kg/l
0.66
42
319
21
200
1.05
0.03
1.0
1.1
1.51
1.46
g/l
0.16
21
184
21
201
1.05
0.03
1.6
1.7
—
—
—
0
0
363
3646
0.99
0.02
3.1
3.4
7.98
8.44
mmol/l
1.08
317
3141
266
2648
1.01
0.01
1.3
1.3
2.83
1.71
u/ml
0.44
78
715
14
147
0.95
0.01
1.6
1.5
—
—
—
0
0
436
4349
1.00
0.01
2.2
2.3
77.76
74.08
nmol/l
1.65
401
3960
10
94
1.06
0.01
1.1
1.1
—
—
—
0
0
20
196
1.02
0.00
1.1
1.2
—
—
—
0
0
10
101
0.99
0.00
1.3
1.9
—
—
—
0
0
26
259
1.00
0.00
2.0
1.8
2.98
5.59
iu/l
1.81
12
88
74
741
1.00
0.00
1.2
1.3
17.92
60.42
au/ml
—
6
42
10
97
1.03
0.00
2.1
2.4
—
—
—
0
0
20
197
1.02
0.00
1.0
1.1
0.98
4.20
u/ml
—
6
102
42
415
1.01
0.00
1.6
1.5
35.24
21.39
iu/l
1.55
36
338
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
5
59
0.85
0.00
7.0
7.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
5
50
1.00
0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
2.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
6
61
0.98
-0.00
1.2
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.9
—
1.56
—
0
8
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
6
65
0.92
-0.00
3.7
5.4
6.47
8.42
mg/l
—
6
57
6
63
0.95
-0.00
1.8
3.1
1850.67
2012.44
ml
—
6
57
0
6
0.00
-0.00
0.0
1.0
—
155.17
—
0
6
7
69
1.01
-0.00
1.3
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
5.0
—
420.44
—
0
9
0
8
0.00
-0.00
0.0
1.3
—
7.08
—
0
8
0
8
0.00
-0.00
0.0
2.3
—
199.75
—
0
8
6
65
0.92
-0.00
4.5
3.0
—
—
—
0
0
8
80
1.00
-0.00
1.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
15.37
—
0
6
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
4.1
—
—
—
0
0
6
65
0.92
-0.00
9.0
6.1
—
—
—
0
0
8
87
0.92
-0.00
1.7
1.8
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: Q17_BICUSP_AORTIC_VALVE – Bicuspidal aortic valve syndrome

GWS hits: 1

This endpoint is excluded (different definition than used in FinnGen).