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Congenital malformations of aortic and mitral valves

Q17_CONGEN_MALFO_AORTIC_MITRAL_VALVES

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 Q23
  • Cause of death: ICD-10 Q23

2 out of 7 registries used, show all original rules.

1534

4. Check minimum number of events

None

1534

5. Include endpoints

None

1534

6. Filter based on genotype QC (FinnGen only)

1534

Control definitions (FinnGen only)

Control exclude
Q17_CONGEN_MALFO_CIRCULATO_SYSTEM

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF9
Parent code in ICD-10
Q2

Similar endpoints

List of similar endpoints to Congenital malformations of aortic and mitral valves based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 1534 526 1008
Unadjusted period prevalence (%) 0.35 0.18 0.44
Median age at first event (years) 51.04 46.82 53.25

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1355
Matched controls
13548
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
46.3
323.0
583
217
I35.0
ICD-10 Finland
Aortic (valve) stenosis
42.0
323.0
525
201
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
12.9
323.0
828
1466
Q23.11
ICD-10 Finland
Bicuspid aortic valve
4503599627370496.0
323.0
1161
*
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
23.2
323.0
509
342
I71.2
ICD-10 Finland
Thoracic aortic aneurysm, without mention of rupture
47.6
323.0
419
126
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
35.2
323.0
468
200
I35.2
ICD-10 Finland
Aortic (valve) stenosis with insufficiency
57.5
299.0
352
82
B01AA03
ATC
warfarin; systemic
11.3
297.5
666
1069
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
60.2
292.1
341
75
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
10.1
275.0
656
1147
FMD00
NOMESCO Finland
Replacement of aortic valve using mechanical prosthesis
125.9
225.7
239
23
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
6.4
175.8
566
1356
WX872
NOMESCO Finland
Intensive care
13.5
165.9
306
287
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
6.2
150.5
481
1101
Q25.1
ICD-10 Finland
Coarctation of aorta
+∞
149.8
141
*
Q23.0
ICD-10 Finland
Congenital stenosis of aortic valve
+∞
129.3
122
*
FMD10
NOMESCO Finland
Replacement of aortic valve using biological prosthesis
44.8
128.6
159
40
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.0
124.1
800
3598
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
7.7
122.8
314
511
Q23.10
ICD-10 Finland
Congenital insufficiency of aortic valve
+∞
121.7
115
*
I71.9
ICD-10 Finland
Aortic aneurysm of unspecified site, without mention of rupture
36.3
119.7
155
48
C07AB07
ATC
bisoprolol; oral
3.9
117.8
763
3386
K83
ICPC
Heart valve disease NOS
57.2
117.7
139
27
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
7.8
110.9
279
438
FCA60
NOMESCO Finland
Resection of aortic root and ascending aorta with reimplantation of coronary arteries and use of composite graft with mechanical valve prosthesis
122.4
95.4
102
9
PD5BD
NOMESCO Finland
Extensive CT of aorta
22.8
94.0
138
67
FCA50
NOMESCO Finland
Resection and reconstruction of ascending aorta using tube graft
86.1
86.3
96
12
ZXE20
NOMESCO Finland
More than three and less than five hours
4.4
79.7
337
955
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
17.9
79.2
126
77
XF404
NOMESCO Finland
Ambulatory ECG
5.6
77.9
250
526
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
8.0
72.6
174
245
201
Kela drug reimbursment
Chronic cardiac insufficiency
9.0
70.4
156
193
PC1BD
NOMESCO Finland
Extensive CT of thoracic aorta
63.5
67.3
78
13
PD5CG
NOMESCO Finland
Extensive MRI examination of thoracal and abdominal aortta with high intensity magnet
122.9
65.5
70
6
XF402
NOMESCO Finland
ECG with work load test
4.5
63.3
252
659
FM1DG
NOMESCO Finland
Very extensive MRI examination of heart with high intesity magnet
15.7
63.0
105
72
TPH07
NOMESCO Finland
Cathetrisation of artery
4.5
62.2
244
628
B01AB05
ATC
enoxaparin; parenteral
3.0
61.9
474
2084
Q21.10
ICD-10 Finland
Persistent ostium secundum
+∞
59.8
57
*
I48
ICD-10 Finland
Atrial fibrillation and flutter
3.5
59.8
336
1181
C03CA01
ATC
furosemide; systemic
3.2
59.0
377
1456
XF400
NOMESCO Finland
ECG with 12 standard connections
3.4
58.8
334
1183
WX408
NOMESCO Finland
General anesthesy, balanced
2.8
58.0
510
2426
ZXE30
NOMESCO Finland
More than five and less than seven hours
5.6
54.0
167
329
Q21.08
ICD-10 Finland
Other specifed ventricular septal defect
+∞
53.5
51
*
FM2CE
NOMESCO Finland
NA
13.6
52.7
93
73
TFC99
NOMESCO Finland
Catheterisation of heart with other procedure
69.6
52.6
60
9
AB1
HP
AVR mechanical
57.9
52.0
61
11
Q23.4
ICD-10 Finland
Hypoplastic left heart syndrome
+∞
50.3
48
*
Q21.09
ICD-10 Finland
Ventricular septal defect NOS
+∞
49.3
47
*
Q23.3
ICD-10 Finland
Congenital mitral insufficiency
+∞
49.3
47
*
Q21.00
ICD-10 Finland
Multiple ventricular septal defect
+∞
48.2
46
*
TFP20
NOMESCO Finland
Cardiodefibrillation
4.9
47.8
166
372
31
HP
Congenital heart failure surgery
+∞
45.0
43
*
GAE10
NOMESCO Finland
Closure of previous incision of chest wall
82.9
43.1
48
6
XF640
NOMESCO Finland
NA
8.6
42.5
95
118
XF622
NOMESCO Finland
Measurement of minute volume of heart
69.4
41.3
47
7
K84
ICPC
Heart disease other
9.2
40.7
87
100
XFE00
NOMESCO Finland
Epicardial ultrasonography
8.9
40.3
88
105
TFP00
NOMESCO Finland
Temporary use of transvenous or epicardial pacemaker
19.6
39.5
60
32
AN1
HP
Coronary angiography
3.6
38.8
195
611
R4110
NOMESCO Finland
Physiotherapy
2.4
38.7
436
2265
Q25.0
ICD-10 Finland
Patent ductus arteriosus
+∞
37.7
36
*
C03DA01
ATC
spironolactone; oral
3.7
37.6
181
547
WX402
NOMESCO Finland
General anaesthesia
2.6
37.5
314
1388
XF600
NOMESCO Finland
Bloodpressure measurement
4.0
37.3
160
438
61
HP
Catheterization and pressure measurement of the left side of the heart
13.6
36.7
64
49
AJ1
HP
Reconstruction of the aortic base, eg composite graft, incl. valve saving operation
100.3
35.9
39
*
ZXD10
NOMESCO Finland
Scheduled procedure
2.1
35.0
562
3401
PD5BG
NOMESCO Finland
MRI examination of thoracal and abdominal aortta with high intensity magnet
80.3
35.0
39
5
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
7.0
34.9
89
135
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
12.7
34.4
62
51
FM1CG
NOMESCO Finland
Extensive examination of hear with high intensity magnet
23.1
34.1
49
22
WZC30
NOMESCO Finland
Teaching
2.9
34.0
232
898
FCA70
NOMESCO Finland
Resection of aortic root and ascending aorta with reimplantation of coronary arteries and use of biological valve prosthesis and tube graft
95.0
33.9
37
*
I35.9
ICD-10 Finland
Aortic valve disorder, unspecified
34.1
33.3
43
13
Z2221
NOMESCO Finland
Medical doctor
2.2
32.7
423
2310
7471A
ICD-9 Finland
Other congenital anomalies of circulatory system, Coarctation of aorta[COARCTATIO AORTAE]
+∞
32.4
31
*
FDA00
NOMESCO Finland
Aortoplasty and aorto-pulmonary shunt for HLHS
+∞
32.4
31
*
74719
ICD-8 Finland
Other congenital anomalies of circulatory system, Coarctation of aorta
324.3
32.0
32
*
FXA10
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia at concurrent surgical procedure
116.1
31.8
34
*
PD5DG
NOMESCO Finland
Very extensive MRI examination of thoracal and abdominal aortta with high intensity magnet
319.9
30.9
31
*
I44.2
ICD-10 Finland
Atrioventricular block, complete
9.2
30.6
65
74
K78
ICPC
Atrial fibrillation/flutter
4.2
30.4
120
303
Q21.11
ICD-10 Finland
Paten or persistent foramen ovale
+∞
30.3
29
*
WX892
NOMESCO Finland
Monitored bed care
3.4
30.0
153
482
J01CA04
ATC
amoxicillin; systemic
2.3
30.0
1136
9436
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
4.4
29.8
114
279
62
HP
Catheterization and pressure measurement of the right side of the heart
58.0
29.2
34
6
I97.0
ICD-10 Finland
Postcardiotomy syndrome
28.6
29.0
39
14
C01AA05
ATC
digoxin; systemic
4.6
28.9
105
244
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
3.4
28.3
145
457
PD5AD
NOMESCO Finland
CT of aorta
12.3
28.1
51
43
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.9
27.8
613
4084
FCA75
NOMESCO Finland
Valve-sparing repair of aortic root (David, Yacoub)
148.0
27.7
29
*
ZXD05
NOMESCO Finland
Urgent procedure
2.0
27.0
423
2466
C01BD01
ATC
amiodarone; systemic
6.3
26.8
73
122
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
6.4
26.5
71
116
I33.0
ICD-10 Finland
Acute and subacute infective endocarditis
16.6
26.4
42
26
Q25.40
ICD-10 Finland
Aortic hypoplasia
+∞
26.1
25
*
AB2
HP
AVR bio, stent
24.6
25.8
36
15
Z95.3
ICD-10 Finland
Presence of xenogenic heart valve
25.6
25.3
35
14
Q20.3
ICD-10 Finland
Discordant ventriculoarterial connection
+∞
25.1
24
*
ZXE40
NOMESCO Finland
More than seven and less than nine hours
5.8
25.0
72
129
WW502
NOMESCO Finland
Autotransfusion
14.4
24.9
42
30
I35.8
ICD-10 Finland
Other aortic valve disorders
39.6
24.9
31
8
I50.9
ICD-10 Finland
Heart failure, unspecified
3.1
24.7
149
527
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
4.6
24.6
89
206
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
4.5
24.6
90
211
Z95.8
ICD-10 Finland
Presence of other cardiac and vascular implants and grafts
28.1
24.5
33
12
C09AA05
ATC
ramipril; oral
2.2
24.5
302
1582
AJ2
HP
Reconstruction of the ascending aorta
49.3
24.3
29
6
FDF05
NOMESCO Finland
Percutaneous transluminal occlusion of aorto-pulmonary collaterals
+∞
24.0
23
*
FN1CD
NOMESCO Finland
Very extensive CT of coronary arteries
14.7
24.0
40
28
FC1AC
NOMESCO Finland
Angiography of thoracal aortta
19.4
24.0
36
19
PD5CD
NOMESCO Finland
Very extensive CT angiography of aorta
23.4
22.6
32
14
FMD40
NOMESCO Finland
Replacement of aortic root using pulmonary autograft and reimplantation of coronary arteries (Ross)
+∞
21.9
21
*
Q23.8
ICD-10 Finland
Other congenital malformations of aortic and mitral valves
+∞
21.9
21
*
Q22.1
ICD-10 Finland
Congenital pulmonary valve stenosis
+∞
21.9
21
*
7463A
ICD-9 Finland
Other congenital anomalies of heart, Congenital stenosis of aortic valve[STENOSIS VALVULAE AORTAE CONGENITA]
+∞
21.9
21
*
FEB10
NOMESCO Finland
Decompression and drainage of pericardium
25.5
21.8
30
12
ZXE00
NOMESCO Finland
One hour or less
1.8
21.8
539
3641
FME20
NOMESCO Finland
Transvenous aortic valve replacement via femoral artery
14.8
21.7
36
25
21
HP
Aortic Valve Replacement (AVR)
223.4
21.7
22
*
FAE10
NOMESCO Finland
Bidirectional anastomosis between superior vena cava and pulmonary artery
+∞
20.9
20
*
Q25.3
ICD-10 Finland
Stenosis of aorta
+∞
20.9
20
*
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.9
20.5
396
2449
K99
ICPC
Cardiovascular disease other
5.8
20.2
58
104
ZXE10
NOMESCO Finland
More than one and less than three hours
1.8
20.1
468
3080
FPE20
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with atrial and ventricular electrodes
5.0
19.6
64
134
O99.4
ICD-10 Finland
Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium
25.0
19.6
27
11
R07.4
ICD-10 Finland
Chest pain, unspecified
1.9
19.5
323
1885
R01.1
ICD-10 Finland
Cardiac murmur, unspecified
5.6
19.2
56
103
FC1BC
NOMESCO Finland
Extensive angiography of thoracal aortta
26.5
19.2
26
10
WX704
NOMESCO Finland
Intubation
2.9
19.0
118
425
WX882
NOMESCO Finland
High dependency care
3.6
19.0
89
262
I35
ICD-10 Finland
Nonrheumatic aortic valve disorders
55.8
19.0
22
*
Q20.48
ICD-10 Finland
Single ventricle
+∞
18.8
18
*
Q23.9
ICD-10 Finland
Congenital malformation of aortic and mitral valves, unspecified
+∞
18.8
18
*
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
3.4
18.8
95
297
FXA20
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia and circulatory arrest at concurrent surgical procedure
70.9
18.7
21
*
FN1BB
NOMESCO Finland
Contrast angiography of heart and/or coronary arteries after bypass surgery
8.7
18.7
40
47
74639
ICD-8 Finland
Congenital anomalies of heart, Defectus septi ventriculorum
192.5
18.6
19
*
N02BE01
ATC
paracetamol; systemic, rectal
1.8
18.5
1038
8780
207
Kela drug reimbursment
Chronic arrhythmias
2.4
18.4
162
716
C07AB02
ATC
metoprolol; systemic
2.1
18.3
224
1155
Q23.1
ICD-10 Finland
Congenital insufficiency of aortic valve
+∞
17.7
17
*
I25.1
ICD-10 Finland
Atherosclerotic heart disease
2.1
17.7
233
1238
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
4.2
17.0
65
160
FAE00
NOMESCO Finland
Anastomosis to pulmonary artery from superior vena cava
+∞
16.7
16
*
Q21.0
ICD-10 Finland
Ventricular septal defect
+∞
16.7
16
*
Q24.4
ICD-10 Finland
Congenital subaortic stenosis
+∞
16.7
16
*
FFC22
NOMESCO Finland
Percutaneous transluminal closure of ostium secundum type ASD
+∞
16.7
16
*
Z95.4
ICD-10 Finland
Presence of other heart-valve replacement
35.5
16.7
21
6
ZXE50
NOMESCO Finland
More than nine and less than 12 hours
6.7
16.7
42
64
I71.00
ICD-10 Finland
Dissecting aneurysm of aorta (ruptured) [any part]
16.5
16.6
26
16
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
3.0
16.5
97
338
TPH04
NOMESCO Finland
Cathetrisation of vein
1.9
16.3
273
1586
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
3.0
16.3
98
345
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.9
16.1
285
1691
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
5.6
16.1
47
87
C09CA01
ATC
losartan; oral
1.9
16.0
274
1608
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.8
15.8
104
387
I34.1
ICD-10 Finland
Mitral (valve) prolapse
4.7
15.7
53
116
74673
ICD-8 Finland
Congenital anomalies of heart, Stenosis valvulae aortae
+∞
15.6
15
*
I37.0
ICD-10 Finland
Pulmonary valve stenosis
161.7
15.5
16
*
FMC20
NOMESCO Finland
Suture of leaflet of aortic valve
161.7
15.5
16
*
K22
ICPC
Risk factor cardiovascular disease
3.6
15.4
71
207
R50.9
ICD-10 Finland
Fever, unspecified
2.0
15.3
218
1191
7AX01
NOMESCO Finland
NA
29.0
15.2
20
7
Q25.48
ICD-10 Finland
Other congenital malformations of the aorta
+∞
14.6
14
*
5513
FHL
Coarctation resection, plastic or bypass
+∞
14.6
14
*
RS224
NOMESCO Finland
NA
8.2
14.6
32
40
GAA10
NOMESCO Finland
Intercostal insertion of pleural drainage tube
5.8
14.6
41
73
I38
ICD-10 Finland
Endocarditis, valve unspecified
36.4
14.5
18
5
5253
FHL
Cardiac lung machine
14.6
14.1
23
16
I11.9
ICD-10 Finland
Hypertensive heart disease without (congestive) heart failure
3.6
13.8
62
177
Z98.8
ICD-10 Finland
Other specified postsurgical states
5.6
13.6
39
71
FDJ00
NOMESCO Finland
End to end reconstruction of aorta for coarctation
+∞
13.6
13
*
Q23.20
ICD-10 Finland
Congenital mitral stenosis
+∞
13.6
13
*
FBE10
NOMESCO Finland
Expansion or reconstruction of pulmonary artery using patch
+∞
13.6
13
*
FBE32
NOMESCO Finland
Percutaneous transluminal angioplasty of pulmonary artery
+∞
13.6
13
*
FXA13
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia and exclusive cerebral perfusion
+∞
13.6
13
*
FMC96
NOMESCO Finland
Other operation on aortic valve for insufficiency
+∞
13.6
13
*
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
5.7
13.2
37
66
R06.0
ICD-10 Finland
Dyspnoea
1.8
13.2
265
1628
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
2.5
13.2
103
427
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.7
13.1
92
356
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.6
13.0
376
2570
AA1AD
NOMESCO Finland
CT of head and brain
1.8
13.0
257
1573
PD5CM
NOMESCO Finland
Extensive MRI examination of thoracal and abdominal aorta with 3 Tesla magnet
70.5
12.6
14
*
FWD00
NOMESCO Finland
Reoperation for superficial haemorrhage in surgery of heart and major thoracic vessels
11.1
12.5
23
21
FDJ42
NOMESCO Finland
Percutaneous transluminal angioplasty of thoracic aorta in coarctation
+∞
12.5
12
*
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
12.5
258
1598
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.9
12.5
212
1232
ZSF00
NOMESCO Finland
Procedure related to previous procedure classified in chapter F
24.5
12.5
17
7
Z3231
NOMESCO Finland
Registered nurse
1.6
12.3
373
2578
C08CA01
ATC
amlodipine; oral
1.6
12.1
365
2513
I49.3
ICD-10 Finland
Ventricular premature depolarization
2.6
11.9
85
334
G04BE03
ATC
sildenafil; oral
5.3
11.8
35
67
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
2.6
11.6
85
341
FAE30
NOMESCO Finland
Total cavo-pulmonary connection using fenestrated patch
+∞
11.5
11
*
FMA20
NOMESCO Finland
Plastic repair of aortic valve for stenosis
+∞
11.5
11
*
5255
FHL
Deep hypothermia (<20 °) with cardiopulmonary resuscitation
+∞
11.5
11
*
Q21.19
ICD-10 Finland
Atrial septal defect NOS
+∞
11.5
11
*
FBE35
NOMESCO Finland
Percutaneous transluminal angioplasty of pulmonary artery with insertion of stent
+∞
11.5
11
*
I47.1
ICD-10 Finland
Supraventricular tachycardia
3.0
11.4
65
223
FFM10
NOMESCO Finland
Occlusion or excision of atrial appendage externally with a closing device
15.2
11.3
18
12
FN1CC
NOMESCO Finland
Very extensive angiography of heart and/or coronary arteries
6.3
11.2
29
47
FM1CD
NOMESCO Finland
Very extensive CT of heart
17.2
11.2
17
10
FPD10
NOMESCO Finland
Surgical ablation of atrial fibrillation
25.2
11.1
15
6
WX870
NOMESCO Finland
Other postsurgical intensive care
11.3
11.1
20
18
211
HP
AVR mechanical
43.7
10.9
13
*
I10
ICD-10 Finland
Essential (primary) hypertension
1.5
10.8
572
4470
FNC10
NOMESCO Finland
Aorto-coronary venous bypass with single distal anastomosis
5.4
10.8
31
58
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
3.0
10.7
61
208
I71.1
ICD-10 Finland
Thoracic aortic aneurysm, ruptured
28.3
10.7
14
5
ZXX09
NOMESCO Finland
Extent of procedure, more than 8 units
60.5
10.6
12
*
FCB40
NOMESCO Finland
Resection and reconstruction of aortic arch using tube graft
60.5
10.6
12
*
ZX199
NOMESCO Finland
Other rote
8.6
10.5
22
26
K29
ICPC
Cardiovascular sympt/complt other
3.2
10.5
53
168
FHB50
NOMESCO Finland
Transatrial closure of VSD using patch
+∞
10.4
10
*
FJF20
NOMESCO Finland
Replacement of pulmonary valve using homograft
+∞
10.4
10
*
Q21.30
ICD-10 Finland
Tetralogy of Fallot
+∞
10.4
10
*
Q20.1
ICD-10 Finland
Double outlet right ventricle
+∞
10.4
10
*
WX002
NOMESCO Finland
Sedation and analgesia
1.7
10.4
216
1335
TFC10
NOMESCO Finland
Catheterisation of left atrium or ventricle
6.4
10.3
26
41
FM1AD
NOMESCO Finland
CT of heart
32.8
10.3
13
*
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
2.1
10.3
120
603
R55
ICD-10 Finland
Syncope and collapse
2.1
10.3
120
604
I50.0
ICD-10 Finland
Congestive heart failure
2.9
10.3
62
222
81
HP
Angiography of the heart and coronary arteries
2.8
10.3
64
233
Z94.1
ICD-10 Finland
Heart transplant status
9.6
10.3
20
21
I31.3
ICD-10 Finland
Pericardial effusion (noninflammatory)
23.5
10.2
14
6
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
2.9
10.2
61
217
I71.01
ICD-10 Finland
Aneurysm of the descending aorta
40.4
10.0
12
*
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
3.6
10.0
43
121
I50.1
ICD-10 Finland
Left ventricular failure
3.2
9.8
50
160
FM1DE
SPAT
NA
20.2
9.8
14
7
A02BC02
ATC
pantoprazole; systemic
1.4
9.8
683
5601
C09AA04
ATC
perindopril; oral
2.7
9.8
66
254
TFP34
NOMESCO Finland
Electrophysiological investigation
3.1
9.7
51
167
H53.1
ICD-10 Finland
Subjective visual disturbances
2.4
9.7
79
338
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.5
9.7
414
3072
XF620
NOMESCO Finland
Examination of circulation with color method
11.5
9.6
17
15
TFJ02
NOMESCO Finland
Muscle biopsy of heart
11.5
9.6
17
15
C09AA02
ATC
enalapril; systemic
1.7
9.4
197
1216
3A566
NOMESCO Finland
NA
100.7
9.4
10
*
I37.1
ICD-10 Finland
Pulmonary valve insufficiency
100.7
9.4
10
*
TGW99
NOMESCO Finland
Other minor procedure in thoracic surgery
30.2
9.4
12
*
C10AA05
ATC
atorvastatin; oral
1.5
9.4
395
2916
FMC10
NOMESCO Finland
Reduction of leaflet of aortic valve
+∞
9.4
9
*
1EA01
NOMESCO Finland
NA
+∞
9.4
9
*
Q22.0
ICD-10 Finland
Pulmonary valve atresia
+∞
9.4
9
*
GAB00
NOMESCO Finland
Emergency thoracotomy
+∞
9.4
9
*
FLE96
NOMESCO Finland
Other repair of outlet obstruction of left ventricle
+∞
9.4
9
*
7454B
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Ventricular septal defect[DEFECTUS SEPTI VENTRICULORUM SIMPLEX]
+∞
9.4
9
*
FQA00
NOMESCO Finland
Orthotopic transplantation of heart
21.8
9.4
13
6
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.0
9.3
116
599
FM1BD
NOMESCO Finland
Extensive CT of heart
13.8
9.2
15
11
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
2.2
9.1
95
455
UGC02
NOMESCO Finland
Rigid bronchoscopy
9.1
9.0
18
20
5273
FHL
Repair with flap prosthesis or graft
36.9
9.0
11
*
XQ903
NOMESCO Finland
Production of other scan or drawing
36.9
9.0
11
*
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
2.5
8.9
70
291
C07AA07
ATC
sotalol; systemic
3.3
8.9
43
133
R04.0
ICD-10 Finland
Epistaxis
2.2
8.8
84
387
FGD00
NOMESCO Finland
Repair of tricuspid valve using suture
50.3
8.7
10
*
324
NOMESCO Finland
NA
27.7
8.5
11
*
Z50.0
ICD-10 Finland
Cardiac rehabilitation
7.4
8.5
19
26
7463D
ICD-9 Finland
Other congenital anomalies of heart, Congenital stenosis of aortic valve[BIKUSPINEN AORTALÄPPÄ]
90.6
8.4
9
*
I33.9
ICD-10 Finland
Acute endocarditis, unspecified
12.8
8.4
14
11
Q21.21
ICD-10 Finland
Atrioventricular duct
+∞
8.3
8
*
FFC00
NOMESCO Finland
Suture of ostium secundum type ASD
+∞
8.3
8
*
FBA96
NOMESCO Finland
Other suture or repair of pulmonary artery
+∞
8.3
8
*
FJE42
NOMESCO Finland
Percutaneous transluminal expansion of pulmonary valve
+∞
8.3
8
*
Q32.11
ICD-10 Finland
Congenital tracheo-esophageal fissure
+∞
8.3
8
*
K73
ICPC
Congenital anomaly cardiovascular
+∞
8.3
8
*
Q26.1
ICD-10 Finland
Persistent left superior vena cava
+∞
8.3
8
*
FJF10
NOMESCO Finland
Replacement of pulmonary valve using biological prosthesis
+∞
8.3
8
*
FDA96
NOMESCO Finland
Other operation for HLHS
+∞
8.3
8
*
Q25.41
ICD-10 Finland
Persistent right-sided aortic arch
+∞
8.3
8
*
FAE96
NOMESCO Finland
Other connection to pulmonary artery from superior vena cava
+∞
8.3
8
*
R42
ICD-10 Finland
Dizziness and giddiness
1.7
8.3
196
1250
C09CA06
ATC
candesartan; oral
1.6
8.3
215
1411
GD1AD
NOMESCO Finland
Thorax CT examination
2.6
8.2
57
224
FXD00
NOMESCO Finland
Use of ECHLA without concurrent surgical procedure
14.6
8.2
13
9
602
Kela drug reimbursment
Children's severe malnutrition
4.1
8.2
30
74
J01DB01
ATC
cefalexin; oral
1.4
8.1
1009
9063
I36.1
ICD-10 Finland
Nonrheumatic tricuspid (valve) insufficiency
6.9
8.1
19
28
I71.09
ICD-10 Finland
Aortic dissection [regardless of location]
9.0
8.0
16
18
3A077
NOMESCO Finland
NA
22.2
8.0
11
5
PA6AE
NOMESCO Finland
Ulrasound examination of neck vasculature
5.9
8.0
21
36
FKB10
NOMESCO Finland
Annuloplasty of mitral valve for insufficiency using ring
5.6
8.0
22
40
A41.9
ICD-10 Finland
Sepsis, unspecified
2.7
7.9
52
199
RK260
NOMESCO Finland
NA
13.1
7.9
13
10
XF614
NOMESCO Finland
Measurement of pulmonary artery pressure
45.2
7.7
9
*
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
2.2
7.7
74
345
ZX120
NOMESCO Finland
Intravenous
1.9
7.6
114
633
FKD00
NOMESCO Finland
Replacement of mitral valve using mechanical prosthesis
25.1
7.6
10
*
I47.2
ICD-10 Finland
Ventricular tachycardia
3.8
7.6
30
80
AP1
HP
Catheterization of the left side of the heart
4.3
7.5
26
61
74699
ICD-8 Finland
Congenital anomalies of heart, Unspecified anomalies of heart
80.5
7.4
8
*
A40.8
ICD-10 Finland
Other streptococcal sepsis
5.6
7.4
20
36
0034
NOMESCO Finland
NA
+∞
7.3
7
*
7455A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Ostium secundum type atrial septal defect
+∞
7.3
7
*
3AE00
NOMESCO Finland
NA
+∞
7.3
7
*
Q24.8
ICD-10 Finland
Other specified congenital malformations of heart
+∞
7.3
7
*
Q25.4
ICD-10 Finland
Other congenital malformations of aorta
+∞
7.3
7
*
Q25.6
ICD-10 Finland
Stenosis of pulmonary artery
+∞
7.3
7
*
Q24.3
ICD-10 Finland
Pulmonary infundibular stenosis
+∞
7.3
7
*
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
2.8
7.2
46
170
FPE30
NOMESCO Finland
Replacement of transvenous cardiac pacemaker pulse generator
6.3
7.2
18
29
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
3.4
7.1
32
95
FPH00
NOMESCO Finland
Transvenous extraction of transvenous cardiac pacemaker or cardioverter-defibrillator
20.1
7.1
10
5
1CX08
NOMESCO Finland
NA
8.0
7.1
15
19
3A064
NOMESCO Finland
NA
12.1
7.1
12
10
Z71.8
ICD-10 Finland
Other specified counselling
1.5
6.9
271
1955
FXF00
NOMESCO Finland
Decannulation after ECHLA or ECLA
13.8
6.9
11
8
3A019
NOMESCO Finland
NA
13.8
6.9
11
8
XA800
NOMESCO Finland
Neuropsychological investigation
2.1
6.8
75
372
4241B
ICD-9 Finland
Other diseases of endocardium, Aortic valve disorders[STENOSIS VALVULAE AORTAE (NON RHEUMATICA)]
40.2
6.8
8
*
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.6
6.7
199
1348
I34.9
ICD-10 Finland
Nonrheumatic mitral valve disorder, unspecified
7.2
6.7
15
21
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.5
6.7
224
1559
GAB20
NOMESCO Finland
Median sternotomy
22.6
6.7
9
*
FN1BD
NOMESCO Finland
Extensive CT of coronary arteries
22.6
6.7
9
*
SPAT1097
SPAT
Recording of ECG
1.7
6.6
136
836
SPAT1249
SPAT
Treatment-related counselling outside office
1.4
6.6
435
3456
G45.3
ICD-10 Finland
Amaurosis fugax
3.9
6.6
25
65
I34.2
ICD-10 Finland
Nonrheumatic mitral (valve) stenosis
12.3
6.6
11
9
1AB02
NOMESCO Finland
NA
12.3
6.6
11
9
AA5HE
NOMESCO Finland
Brain ultrasound examination in a child
3.7
6.5
26
71
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
1.7
6.5
123
737
XF405
NOMESCO Finland
Symptom ECG
5.3
6.5
18
34
I49.4
ICD-10 Finland
Other and unspecified premature depolarization
2.7
6.5
42
160
FXM00
NOMESCO Finland
Removal of extra-, para- or intracorporeal VAD
70.1
6.4
7
*
FPF20
NOMESCO Finland
Implantation of epicardial pacemaker with atrial and ventricular electrodes
70.1
6.4
7
*
90492
NOMESCO Finland
NA
70.1
6.4
7
*
FCA96
NOMESCO Finland
Other repair of ascending aorta
70.1
6.4
7
*
I28.8
ICD-10 Finland
Other specified diseases of pulmonary vessels
70.1
6.4
7
*
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
2.0
6.4
78
401
3A422
NOMESCO Finland
NA
14.4
6.4
10
7
Z01.2
ICD-10 Finland
Dental examination
1.4
6.4
507
4149
K80
ICPC
Cardiac arrhythmia NOS
2.1
6.3
71
352
A41.8
ICD-10 Finland
Other specified sepsis
4.0
6.3
23
58
205
Kela drug reimbursment
Chronic hypertension
1.5
6.3
241
1729
I49.1
ICD-10 Finland
Atrial premature depolarization
2.8
6.3
38
140
FWW96
NOMESCO Finland
Other reoperation on heart or major thoracic vessels
18.1
6.3
9
5
AP3
HP
Catheterization of the right and left side of the heart
18.1
6.3
9
5
FMB10
NOMESCO Finland
Transannular expansion of aortic ostium
+∞
6.3
6
*
5207
FHL
VSD closure
+∞
6.3
6
*
Q21.9
ICD-10 Finland
Congenital malformation of cardiac septum, unspecified
+∞
6.3
6
*
74659
ICD-8 Finland
Congenital anomalies of heart, Maleformatio valvulae mitralis
+∞
6.3
6
*
Q25.21
ICD-10 Finland
Interrupted aortic arch
+∞
6.3
6
*
FJD20
NOMESCO Finland
Bypass of pulmonary valve with ventriculopulmonary prosthesis or homograft
+∞
6.3
6
*
Q87.14
ICD-10 Finland
Noonan's syndrome
+∞
6.3
6
*
7464A
ICD-9 Finland
Other congenital anomalies of heart, Congenital insufficiency of aortic valve
+∞
6.3
6
*
0557
NOMESCO Finland
NA
+∞
6.3
6
*
GA4AT
NOMESCO Finland
Cathetrisation of pleural cavity with ultrasound guidance
5.8
6.1
16
28
Z3226
NOMESCO Finland
Physiotherapist
1.5
6.1
225
1602
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.7
6.0
119
721

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: Q17_CONGEN_MALFO_AORTIC_MITRAL_VALVES – Congenital malformations of aortic and mitral valves

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).