No definition available.
Congenital malformations of great arteries
DOID EFO Endpoint Browser PheWeb
Q17_CONGEN_MALFO_GREAT_ARTERIES
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
807 |
4. Check minimum number of eventsNone |
807 |
5. Include endpointsNone |
807 |
6. Filter based on genotype QC (FinnGen only) |
760 |
Control definitions (FinnGen only)
- Control exclude
- Q17_CONGEN_MALFO_CIRCULATO_SYSTEM
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- Q2
- Name in latin
- Malformationes congenitae arteriarum magnarum
Similar endpoints
↥List of similar endpoints to
Congenital malformations of great arteries
based on the number of shared cases.
Similar with more cases:
- Congenital malformations of heart and great arteries
- Congenital malformations of the circulatory system
- Congenital malformations, deformations and chromosomal abnormalities
- Congenital malformations, deformations and chromosomal abnormalities
- Any operation in hilmo
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 11820 | 5910 | 5895 |
| Only index persons | 7116 | 3524 | 3592 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.17 | 0.17 | 0.16 |
| Only index persons | 0.13 | 0.13 | 0.14 |
| Median age at first event (years) | |||
| Whole population | 0.49 | 0.43 | 0.38 |
| Only index persons | 3.34 | 3.12 | 3.56 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 760 | 393 | 367 |
| Unadjusted period prevalence (%) | 0.15 | 0.14 | 0.17 |
| Median age at first event (years) | 14.02 | 12.74 | 15.40 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 805
- Matched controls
- 7896
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
41.3
317.6
203
64
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
13.2
311.8
495
854
Q25.1
ICD-10 Finland
Coarctation of aorta
+∞
307.7
345
*
Q25.0
ICD-10 Finland
Patent ductus arteriosus
+∞
307.7
300
*
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
26.6
300.6
227
115
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
36.3
275.7
182
63
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
11.6
248.9
340
468
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
22.8
182.1
141
73
XF400
NOMESCO Finland
ECG with 12 standard connections
7.8
178.1
351
711
201
Kela drug reimbursment
Chronic cardiac insufficiency
22.3
175.6
137
72
Q23.11
ICD-10 Finland
Bicuspid aortic valve
+∞
162.1
151
*
FM2CE, ,
NOMESCO Finland
12.7
159.7
173
166
TFC99
NOMESCO Finland
Catheterisation of heart with other procedure
85.8
146.5
79
10
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
9.8
143.7
192
245
B01AA03
ATC
warfarin; systemic
8.8
140.9
209
303
61
HP
Catheterization and pressure measurement of the left side of the heart
56.1
126.2
73
14
XF402
NOMESCO Finland
ECG with work load test
9.5
119.0
158
198
FM1DG
NOMESCO Finland
Very extensive MRI examination of heart with high intesity magnet
27.4
117.9
83
33
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
7.9
116.5
186
290
XF600
NOMESCO Finland
Bloodpressure measurement
7.1
115.7
209
372
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
35.7
113.2
73
22
I35.0
ICD-10 Finland
Aortic (valve) stenosis
15.7
112.9
103
73
Q21.08
ICD-10 Finland
Other specifed ventricular septal defect
+∞
112.4
106
*
I71.2
ICD-10 Finland
Thoracic aortic aneurysm, without mention of rupture
25.9
110.1
79
33
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.9
109.1
486
1871
TPH07
NOMESCO Finland
Cathetrisation of artery
6.6
106.3
204
384
74719
ICD-8 Finland
Other congenital anomalies of circulatory system, Coarctation of aorta
1116.7
103.9
100
*
XF404
NOMESCO Finland
Ambulatory ECG
7.9
101.9
159
240
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
5.4
101.8
267
668
XFE00
NOMESCO Finland
Epicardial ultrasonography
25.3
100.9
73
31
Q21.10
ICD-10 Finland
Persistent ostium secundum
+∞
96.2
91
*
Q21.00
ICD-10 Finland
Multiple ventricular septal defect
+∞
91.8
87
*
FN1BB
NOMESCO Finland
Contrast angiography of heart and/or coronary arteries after bypass surgery
30.6
86.0
58
20
C03CA01
ATC
furosemide; systemic
5.1
85.4
224
553
ZXE20
NOMESCO Finland
More than three and less than five hours
5.0
78.4
207
511
7471A
ICD-9 Finland
Other congenital anomalies of circulatory system, Coarctation of aorta[COARCTATIO AORTAE]
+∞
77.9
74
*
Q21.09
ICD-10 Finland
Ventricular septal defect NOS
+∞
76.8
73
*
I35.2
ICD-10 Finland
Aortic (valve) stenosis with insufficiency
20.3
71.1
56
29
C03DA01
ATC
spironolactone; oral
6.3
70.8
134
244
31
HP
Congenital heart failure surgery
+∞
70.4
67
*
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
35.1
68.1
44
13
Z98.8
ICD-10 Finland
Other specified postsurgical states
20.9
64.3
50
25
GAE10
NOMESCO Finland
Closure of previous incision of chest wall
325.7
60.8
61
*
ZXE30
NOMESCO Finland
More than five and less than seven hours
6.1
60.7
116
212
WX408
NOMESCO Finland
General anesthesy, balanced
3.4
60.4
341
1408
Q25.3
ICD-10 Finland
Stenosis of aorta
+∞
59.7
57
*
C01AA05
ATC
digoxin; systemic
9.1
59.6
77
91
ZXE10
NOMESCO Finland
More than one and less than three hours
3.3
59.1
370
1621
ZXD10
NOMESCO Finland
Scheduled procedure
3.2
58.2
414
1951
G04BE03
ATC
sildenafil; oral
23.5
55.5
41
18
Q21.11
ICD-10 Finland
Paten or persistent foramen ovale
+∞
55.5
53
*
Q23.0
ICD-10 Finland
Congenital stenosis of aortic valve
+∞
55.5
53
*
Z2221
NOMESCO Finland
Medical doctor
3.2
54.9
332
1413
WX872
NOMESCO Finland
Intensive care
8.5
53.6
73
92
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
4.1
51.4
165
464
FDE32
NOMESCO Finland
Percutaneous transluminal closure of patent ductus arteriosus
+∞
50.2
48
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.1
47.3
289
1219
Q25.40
ICD-10 Finland
Aortic hypoplasia
+∞
47.0
45
*
Q25.48
ICD-10 Finland
Other congenital malformations of the aorta
+∞
46.0
44
*
ZXE40
NOMESCO Finland
More than seven and less than nine hours
8.0
45.4
64
84
FM1CG
NOMESCO Finland
Extensive examination of hear with high intensity magnet
76.0
45.2
51
7
Q20.3
ICD-10 Finland
Discordant ventriculoarterial connection
+∞
44.9
43
*
C01BD01
ATC
amiodarone; systemic
14.1
43.5
41
30
62
HP
Catheterization and pressure measurement of the right side of the heart
119.5
42.9
46
*
Q25.6
ICD-10 Finland
Stenosis of pulmonary artery
+∞
42.8
41
*
PD5CG
NOMESCO Finland
Extensive MRI examination of thoracal and abdominal aortta with high intensity magnet
420.5
41.2
41
*
XF622
NOMESCO Finland
Measurement of minute volume of heart
148.3
40.8
43
*
Q25.41
ICD-10 Finland
Persistent right-sided aortic arch
+∞
40.7
39
*
C07AB07
ATC
bisoprolol; oral
2.8
39.0
292
1350
WX882
NOMESCO Finland
High dependency care
3.9
38.6
126
355
FBE32
NOMESCO Finland
Percutaneous transluminal angioplasty of pulmonary artery
+∞
37.5
36
*
Q25.78
ICD-10 Finland
Other congenital malformations of pulmonary artery
+∞
37.5
36
*
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
7.0
36.0
57
85
FXA10
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia at concurrent surgical procedure
366.2
36.0
36
*
205
Kela drug reimbursment
Chronic hypertension
3.3
35.6
154
521
FMD00
NOMESCO Finland
Replacement of aortic valve using mechanical prosthesis
60.4
35.2
41
7
WX402
NOMESCO Finland
General anaesthesia
2.7
34.8
269
1253
XF640, ,
NOMESCO Finland
11.5
34.8
37
33
Q23.10
ICD-10 Finland
Congenital insufficiency of aortic valve
+∞
34.4
33
*
Q21.30
ICD-10 Finland
Tetralogy of Fallot
+∞
34.4
33
*
RS224, ,
NOMESCO Finland
10.3
33.9
39
39
Q22.1
ICD-10 Finland
Congenital pulmonary valve stenosis
+∞
32.3
31
*
TFP20
NOMESCO Finland
Cardiodefibrillation
5.6
31.7
63
118
WX892
NOMESCO Finland
Monitored bed care
3.8
31.4
107
309
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
9.5
31.3
38
41
ZXD05
NOMESCO Finland
Urgent procedure
2.5
30.3
273
1353
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
7.0
30.1
47
69
C07AB02
ATC
metoprolol; systemic
3.3
29.6
127
425
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
3.3
29.1
121
397
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
10.9
29.0
32
30
FBE10
NOMESCO Finland
Expansion or reconstruction of pulmonary artery using patch
+∞
28.1
27
*
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
4.0
27.8
84
222
PD5DG
NOMESCO Finland
Very extensive MRI examination of thoracal and abdominal aortta with high intensity magnet
101.8
27.6
30
*
FHB50
NOMESCO Finland
Transatrial closure of VSD using patch
+∞
27.0
26
*
Z3231
NOMESCO Finland
Registered nurse
2.3
26.7
331
1864
K83
ICPC
Heart valve disease NOS
76.4
26.7
30
*
74709
ICD-8 Finland
Other congenital anomalies of circulatory system, Patent ductus arteriosus
274.6
26.7
27
*
I48
ICD-10 Finland
Atrial fibrillation and flutter
3.3
26.6
111
364
Q24.4
ICD-10 Finland
Congenital subaortic stenosis
+∞
26.0
25
*
FBE35
NOMESCO Finland
Percutaneous transluminal angioplasty of pulmonary artery with insertion of stent
+∞
26.0
25
*
R4110
NOMESCO Finland
Physiotherapy
2.3
26.0
281
1492
I50.9
ICD-10 Finland
Heart failure, unspecified
4.0
25.9
79
210
5513
FHL
Coarctation resection, plastic or bypass
+∞
24.9
24
*
ZXE50
NOMESCO Finland
More than nine and less than 12 hours
7.5
24.6
36
49
K84
ICPC
Heart disease other
8.6
24.4
32
38
I44.2
ICD-10 Finland
Atrioventricular block, complete
9.5
24.0
29
31
FJF20
NOMESCO Finland
Replacement of pulmonary valve using homograft
+∞
23.9
23
*
I71.9
ICD-10 Finland
Aortic aneurysm of unspecified site, without mention of rupture
38.1
23.9
30
8
WX704
NOMESCO Finland
Intubation
3.6
23.7
84
248
JDB10
NOMESCO Finland
Percutaneous gastrostomy
8.5
23.6
31
37
Q21.0
ICD-10 Finland
Ventricular septal defect
+∞
22.9
22
*
Q26.1
ICD-10 Finland
Persistent left superior vena cava
+∞
22.9
22
*
Q20.1
ICD-10 Finland
Double outlet right ventricle
+∞
22.9
22
*
FDJ42
NOMESCO Finland
Percutaneous transluminal angioplasty of thoracic aorta in coarctation
+∞
22.9
22
*
FDJ00
NOMESCO Finland
End to end reconstruction of aorta for coarctation
+∞
22.9
22
*
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
5.9
22.3
41
71
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
4.7
21.8
52
114
FDF05
NOMESCO Finland
Percutaneous transluminal occlusion of aorto-pulmonary collaterals
+∞
21.8
21
*
PD5BD
NOMESCO Finland
Extensive CT of aorta
20.4
21.6
32
16
FCA60
NOMESCO Finland
Resection of aortic root and ascending aorta with reimplantation of coronary arteries and use of composite graft with mechanical valve prosthesis
80.9
21.6
24
*
O99.4
ICD-10 Finland
Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium
34.2
21.0
27
8
GAA10
NOMESCO Finland
Intercostal insertion of pleural drainage tube
8.3
21.0
28
34
Q20.48
ICD-10 Finland
Single ventricle
+∞
20.8
20
*
FXA20
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia and circulatory arrest at concurrent surgical procedure
+∞
20.8
20
*
Q23.4
ICD-10 Finland
Hypoplastic left heart syndrome
+∞
20.8
20
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.3
20.1
185
904
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
4.0
20.0
59
153
ZXE00
NOMESCO Finland
One hour or less
2.0
19.9
353
2216
602
Kela drug reimbursment
Children's severe malnutrition
4.2
19.9
55
136
FDE10
NOMESCO Finland
Ligature of patent ductus arteriosus
+∞
19.7
19
*
Q25.9
ICD-10 Finland
Congenital malformation of great arteries, unspecified
+∞
19.7
19
*
FFC22
NOMESCO Finland
Percutaneous transluminal closure of ostium secundum type ASD
+∞
19.7
19
*
PD5AD
NOMESCO Finland
CT of aorta
7.5
19.1
28
38
XF620
NOMESCO Finland
Examination of circulation with color method
46.3
19.1
23
5
I37.1
ICD-10 Finland
Pulmonary valve insufficiency
+∞
18.7
18
*
C07AA07
ATC
sotalol; systemic
6.6
18.4
30
46
207
Kela drug reimbursment
Chronic arrhythmias
3.2
18.4
76
247
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
16.3
18.2
29
18
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
4.0
18.1
54
141
FMD10
NOMESCO Finland
Replacement of aortic valve using biological prosthesis
19.5
18.1
27
14
FN1CC
NOMESCO Finland
Very extensive angiography of heart and/or coronary arteries
14.5
18.0
30
21
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.2
17.8
181
917
Q25.8
ICD-10 Finland
Other congenital malformations of great arteries
+∞
17.6
17
*
FDA00
NOMESCO Finland
Aortoplasty and aorto-pulmonary shunt for HLHS
+∞
17.6
17
*
Q23.3
ICD-10 Finland
Congenital mitral insufficiency
+∞
17.6
17
*
Q22.0
ICD-10 Finland
Pulmonary valve atresia
+∞
17.6
17
*
7470A
ICD-9 Finland
Other congenital anomalies of circulatory system, Patent ductus arteriosus
95.4
17.5
19
*
FP1B5
NOMESCO Finland
Resting ECG, 12 leads
6.0
17.4
31
52
UGC02
NOMESCO Finland
Rigid bronchoscopy
13.2
17.3
30
23
FPE20
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with atrial and ventricular electrodes
7.4
17.0
25
34
TJD20
NOMESCO Finland
Change of gastrostomy tube
7.1
17.0
26
37
XQ903
NOMESCO Finland
Production of other scan or drawing
31.6
16.9
22
7
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.2
16.9
174
885
Q25.70
ICD-10 Finland
Aneurysm, congenital of pulmonary artery
+∞
16.6
16
*
PD5BG
NOMESCO Finland
MRI examination of thoracal and abdominal aortta with high intensity magnet
170.1
16.4
17
*
1EA01, ,
NOMESCO Finland
+∞
15.6
15
*
FCA50
NOMESCO Finland
Resection and reconstruction of ascending aorta using tube graft
+∞
15.6
15
*
Q25.45
ICD-10 Finland
Congenital aortic aneurysm
+∞
15.6
15
*
Q21.19
ICD-10 Finland
Atrial septal defect NOS
+∞
15.6
15
*
PC1BD
NOMESCO Finland
Extensive CT of thoracic aorta
159.9
15.4
16
*
74639
ICD-8 Finland
Congenital anomalies of heart, Defectus septi ventriculorum
159.9
15.4
16
*
81
HP
Angiography of the heart and coronary arteries
4.9
15.4
34
70
ZX120
NOMESCO Finland
Intravenous
2.6
15.3
93
373
FC1AC
NOMESCO Finland
Angiography of thoracal aortta
45.1
15.0
18
*
R62.0
ICD-10 Finland
Delayed milestone
3.1
14.9
66
223
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
14.7
184
1002
FBJ10
NOMESCO Finland
Anastomosis to pulmonary artery from subclavian artery with interposition graft
+∞
14.5
14
*
Q20.00
ICD-10 Finland
Common arterial trunk
+∞
14.5
14
*
I37.0
ICD-10 Finland
Pulmonary valve stenosis
+∞
14.5
14
*
7454B
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Ventricular septal defect[DEFECTUS SEPTI VENTRICULORUM SIMPLEX]
+∞
14.5
14
*
FXA13
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia and exclusive cerebral perfusion
+∞
14.5
14
*
FFC00
NOMESCO Finland
Suture of ostium secundum type ASD
+∞
14.5
14
*
Q21.32
ICD-10 Finland
Pulmonary atresia with Fallot ventricular septal defect
+∞
14.5
14
*
FJE42
NOMESCO Finland
Percutaneous transluminal expansion of pulmonary valve
+∞
14.5
14
*
Q25.21
ICD-10 Finland
Interrupted aortic arch
+∞
14.5
14
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.3
14.4
56
175
C09AA02
ATC
enalapril; systemic
2.5
14.0
96
408
WZC30
NOMESCO Finland
Teaching
2.3
13.9
116
539
F83
ICD-10 Finland
Mixed specific developmental disorders
3.3
13.7
54
170
R50.9
ICD-10 Finland
Fever, unspecified
2.0
13.6
194
1104
C09AA05
ATC
ramipril; oral
2.3
13.6
113
524
AP3
HP
Catheterization of the right and left side of the heart
75.0
13.5
15
*
B01AB05
ATC
enoxaparin; parenteral
2.0
13.5
164
882
5255
FHL
Deep hypothermia (<20 °) with cardiopulmonary resuscitation
+∞
13.5
13
*
FPF20
NOMESCO Finland
Implantation of epicardial pacemaker with atrial and ventricular electrodes
+∞
13.5
13
*
Q21.21
ICD-10 Finland
Atrioventricular duct
+∞
13.5
13
*
Q25.4
ICD-10 Finland
Other congenital malformations of aorta
+∞
13.5
13
*
AJ1
HP
Reconstruction of the aortic base, eg composite graft, incl. valve saving operation
139.6
13.4
14
*
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
4.4
13.3
34
79
AA5HE
NOMESCO Finland
Brain ultrasound examination in a child
3.1
12.9
56
187
F79.0
ICD-10 Finland
Unspecified mental retardation, with the statement of no, or minimal, impairment of behaviour
4.5
12.8
31
69
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
5.4
12.5
25
47
FLE96
NOMESCO Finland
Other repair of outlet obstruction of left ventricle
+∞
12.4
12
*
FMD40
NOMESCO Finland
Replacement of aortic root using pulmonary autograft and reimplantation of coronary arteries (Ross)
+∞
12.4
12
*
Q21.9
ICD-10 Finland
Congenital malformation of cardiac septum, unspecified
+∞
12.4
12
*
FAE10
NOMESCO Finland
Bidirectional anastomosis between superior vena cava and pulmonary artery
+∞
12.4
12
*
FAE00
NOMESCO Finland
Anastomosis to pulmonary artery from superior vena cava
+∞
12.4
12
*
FBA96
NOMESCO Finland
Other suture or repair of pulmonary artery
+∞
12.4
12
*
FM1CD
NOMESCO Finland
Very extensive CT of heart
129.5
12.4
13
*
AN1
HP
Coronary angiography
3.1
12.3
52
171
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.8
12.1
234
1461
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
3.4
12.1
45
137
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
12.4
12.0
21
17
P85
ICPC
Mental retardation
4.8
11.9
27
57
Z31.5
ICD-10 Finland
Genetic counselling
2.4
11.8
84
363
FCA75
NOMESCO Finland
Valve-sparing repair of aortic root (David, Yacoub)
64.7
11.5
13
*
FEB10
NOMESCO Finland
Decompression and drainage of pericardium
18.9
11.5
17
9
FCC45
NOMESCO Finland
Percutaneous insertion of stent into descending aorta
+∞
11.4
11
*
5609
FHL
Other measure in this category
+∞
11.4
11
*
FPH00
NOMESCO Finland
Transvenous extraction of transvenous cardiac pacemaker or cardioverter-defibrillator
119.4
11.4
12
*
I28.8
ICD-10 Finland
Other specified diseases of pulmonary vessels
119.4
11.4
12
*
K78
ICPC
Atrial fibrillation/flutter
3.7
11.2
36
99
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
3.1
11.2
47
154
7AX01, ,
NOMESCO Finland
17.0
11.1
17
10
RS221, ,
NOMESCO Finland
3.8
11.0
34
91
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
3.0
10.9
48
162
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.9
10.9
144
794
Z2446
NOMESCO Finland
Social worker
2.0
10.8
130
694
FN1CD
NOMESCO Finland
Very extensive CT of coronary arteries
15.4
10.7
17
11
J01CA04
ATC
amoxicillin; systemic
2.2
10.7
719
6267
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.9
10.7
150
844
RK260, ,
NOMESCO Finland
17.8
10.6
16
9
I25.1
ICD-10 Finland
Atherosclerotic heart disease
2.3
10.5
85
388
UDC00
NOMESCO Finland
Ear microscopy
2.4
10.5
78
343
Q87.88
ICD-10 Finland
Other specified congenital malformation syndromes, not elsewhere classified
14.2
10.4
17
12
74673
ICD-8 Finland
Congenital anomalies of heart, Stenosis valvulae aortae
+∞
10.4
10
*
Q24.3
ICD-10 Finland
Pulmonary infundibular stenosis
+∞
10.4
10
*
7463A
ICD-9 Finland
Other congenital anomalies of heart, Congenital stenosis of aortic valve[STENOSIS VALVULAE AORTAE CONGENITA]
+∞
10.4
10
*
Q24.9
ICD-10 Finland
Congenital malformation of heart, unspecified
+∞
10.4
10
*
FBE96
NOMESCO Finland
Other expansion or reconstruction of pulmonary artery
+∞
10.4
10
*
Q20.40
ICD-10 Finland
Double inlet left ventricle
+∞
10.4
10
*
FJD20
NOMESCO Finland
Bypass of pulmonary valve with ventriculopulmonary prosthesis or homograft
+∞
10.4
10
*
5512
FHL
Cleavage or ligation of the ductus arteriosus
109.3
10.4
11
*
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
4.2
10.3
27
64
I33.0
ICD-10 Finland
Acute and subacute infective endocarditis
16.0
10.3
16
10
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.0
10.1
46
158
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
4.9
10.0
22
45
I36.1
ICD-10 Finland
Nonrheumatic tricuspid (valve) insufficiency
14.5
9.9
16
11
1CX08, ,
NOMESCO Finland
39.8
9.9
12
*
I97.0
ICD-10 Finland
Postcardiotomy syndrome
39.8
9.9
12
*
Z3226
NOMESCO Finland
Physiotherapist
1.8
9.8
190
1177
I50.0
ICD-10 Finland
Congestive heart failure
3.5
9.8
33
94
J21.9
ICD-10 Finland
Acute bronchiolitis, unspecified
3.0
9.8
43
145
TFC10
NOMESCO Finland
Catheterisation of left atrium or ventricle
12.1
9.8
17
14
J45.1
ICD-10 Finland
Nonallergic asthma
2.2
9.7
89
428
WX002
NOMESCO Finland
Sedation and analgesia
2.0
9.7
114
603
I47.1
ICD-10 Finland
Supraventricular tachycardia
3.0
9.4
42
143
ZXX09
NOMESCO Finland
Extent of procedure, more than 8 units
99.2
9.4
10
*
90492, ,
NOMESCO Finland
99.2
9.4
10
*
21
HP
Aortic Valve Replacement (AVR)
99.2
9.4
10
*
Q90.0
ICD-10 Finland
Trisomy 21, meiotic nondisjunction
29.8
9.3
12
*
FCC50
NOMESCO Finland
Resection and reconstruction of descending aorta using tube graft
+∞
9.3
9
*
Q90
ICD-10 Finland
Down syndrome
+∞
9.3
9
*
Q25.43
ICD-10 Finland
(Ruptured) aneurysm of sinus Valsalva
+∞
9.3
9
*
FHE30
NOMESCO Finland
Repair of tetralogy of Fallot with transannular patch
+∞
9.3
9
*
FMA20
NOMESCO Finland
Plastic repair of aortic valve for stenosis
+∞
9.3
9
*
GAB00
NOMESCO Finland
Emergency thoracotomy
+∞
9.3
9
*
Q21.31
ICD-10 Finland
Tetralogy of Fallot and double outlet right ventricle
+∞
9.3
9
*
Q24.0
ICD-10 Finland
Dextrocardia
+∞
9.3
9
*
FP4B5
NOMESCO Finland
ECG, prolonged recording (24 h)
8.6
9.2
19
22
R07.4
ICD-10 Finland
Chest pain, unspecified
1.8
9.1
151
893
Z3229
NOMESCO Finland
Other healthcare associate professional
2.1
9.0
92
461
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
2.1
9.0
90
448
PD5CD
NOMESCO Finland
Very extensive CT angiography of aorta
36.4
9.0
11
*
FM1AD
NOMESCO Finland
CT of heart
36.4
9.0
11
*
ZX199
NOMESCO Finland
Other rote
7.0
8.9
21
30
AB1
HP
AVR mechanical
23.8
8.8
12
5
TFP00
NOMESCO Finland
Temporary use of transvenous or epicardial pacemaker
12.5
8.8
15
12
C08CA02
ATC
felodipine; oral
2.8
8.6
42
150
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.5
8.6
57
238
I27.2
ICD-10 Finland
Other secondary pulmonary hypertension
49.6
8.6
10
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.2
8.5
77
368
GD1AD
NOMESCO Finland
Thorax CT examination
3.0
8.4
38
130
Q90.9
ICD-10 Finland
Down syndrome, unspecified
27.3
8.4
11
*
C07AB03
ATC
atenolol; systemic
3.3
8.4
31
94
FM1BD
NOMESCO Finland
Extensive CT of heart
19.9
8.4
12
6
I27.0
ICD-10 Finland
Primary pulmonary hypertension
89.2
8.4
9
*
R06.0
ICD-10 Finland
Dyspnoea
1.7
8.3
156
955
Q25.5
ICD-10 Finland
Atresia of pulmonary artery
+∞
8.3
8
*
5207
FHL
VSD closure
+∞
8.3
8
*
PD5CM
NOMESCO Finland
Extensive MRI examination of thoracal and abdominal aorta with 3 Tesla magnet
+∞
8.3
8
*
Q20.8
ICD-10 Finland
Other congenital malformations of cardiac chambers and connections
+∞
8.3
8
*
I37.2
ICD-10 Finland
Pulmonary valve stenosis with insufficiency
+∞
8.3
8
*
Q22.5
ICD-10 Finland
Ebstein anomaly
+∞
8.3
8
*
AA1AD
NOMESCO Finland
CT of head and brain
1.8
8.2
129
748
C08CA01
ATC
amlodipine; oral
1.7
8.2
158
973
3A019, ,
NOMESCO Finland
10.7
8.2
15
14
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.3
8.2
63
282
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.5
8.0
49
197
FPE30
NOMESCO Finland
Replacement of transvenous cardiac pacemaker pulse generator
11.6
8.0
14
12
I49.5
ICD-10 Finland
Sick sinus syndrome
4.7
7.9
18
38
F82
ICD-10 Finland
Specific developmental disorder of motor function
3.0
7.9
35
119
Z87.6
ICD-10 Finland
Personal history of certain conditions arising in the perinatal period
2.7
7.9
42
158
J21.0
ICD-10 Finland
Acute bronchiolitis due to respiratory syncytial virus
2.9
7.8
36
125
WX870
NOMESCO Finland
Other postsurgical intensive care
10.7
7.7
14
13
I47.2
ICD-10 Finland
Ventricular tachycardia
4.6
7.7
18
39
XX3BT
NOMESCO Finland
Other labeling with X-ray guidance
3.9
7.7
22
56
I10
ICD-10 Finland
Essential (primary) hypertension
1.6
7.7
229
1577
FC1BC
NOMESCO Finland
Extensive angiography of thoracal aortta
44.6
7.7
9
*
XG460
NOMESCO Finland
Short time oxymetry
6.3
7.6
19
30
FWD00
NOMESCO Finland
Reoperation for superficial haemorrhage in surgery of heart and major thoracic vessels
18.2
7.5
11
6
324, ,
NOMESCO Finland
18.2
7.5
11
6
I35.9
ICD-10 Finland
Aortic valve disorder, unspecified
18.2
7.5
11
6
B34.9
ICD-10 Finland
Viral infection, unspecified
2.2
7.4
63
294
74699
ICD-8 Finland
Congenital anomalies of heart, Unspecified anomalies of heart
79.3
7.4
8
*
ZF61V, ,
NOMESCO Finland
79.3
7.4
8
*
I49.3
ICD-10 Finland
Ventricular premature depolarization
2.7
7.4
40
152
Q23.20
ICD-10 Finland
Congenital mitral stenosis
+∞
7.2
7
*
74619
ICD-8 Finland
Congenital anomalies of heart, Transposition of great vessels
+∞
7.2
7
*
FDJ30
NOMESCO Finland
Reconstruction of aorta for coarctation using tube graft
+∞
7.2
7
*
FDE96
NOMESCO Finland
Other closure of patent ductus arteriosus
+∞
7.2
7
*
74659
ICD-8 Finland
Congenital anomalies of heart, Maleformatio valvulae mitralis
+∞
7.2
7
*
7451A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Transposition of great vessels[TRANSPOSITIO CORDIS COMPLETA]
+∞
7.2
7
*
FAE30
NOMESCO Finland
Total cavo-pulmonary connection using fenestrated patch
+∞
7.2
7
*
74729
ICD-8 Finland
Other congenital anomalies of circulatory system, Maleformationes aortae aliae
+∞
7.2
7
*
Q21.20
ICD-10 Finland
Atrial septal defect of primum type
+∞
7.2
7
*
FDH96
NOMESCO Finland
Other operation for interrupted or hypoplastic aortic arch
+∞
7.2
7
*
7455A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Ostium secundum type atrial septal defect
+∞
7.2
7
*
PD5DM
NOMESCO Finland
Very extensive MRI examination of thoracal and abdominal aorta with 3 Tesla magnet
+∞
7.2
7
*
Q26.3
ICD-10 Finland
Partial anomalous pulmonary venous connection
+∞
7.2
7
*
7454A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Ventricular septal defect[DEFECTUS SEPTI VENTRICULORUM NUD]
+∞
7.2
7
*
FBE00
NOMESCO Finland
Expansion of pulmonary artery
+∞
7.2
7
*
Q24.8
ICD-10 Finland
Other specified congenital malformations of heart
+∞
7.2
7
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.0
7.2
82
428
WX250
NOMESCO Finland
Intercostal blockade
15.6
7.2
11
7
3A077, ,
NOMESCO Finland
15.6
7.2
11
7
5253
FHL
Cardiac lung machine
29.7
7.1
9
*
I27.9
ICD-10 Finland
Pulmonary heart disease, unspecified
29.7
7.1
9
*
Z95.8
ICD-10 Finland
Presence of other cardiac and vascular implants and grafts
19.8
7.1
10
5
TFJ02
NOMESCO Finland
Muscle biopsy of heart
11.9
7.0
12
10
XX9BW
NOMESCO Finland
Submitting image material and/or investigation material to authority or other institution
5.6
7.0
19
34
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
2.6
6.9
38
145
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
3.4
6.9
24
70
3820A
ICD-9 Finland
Suppurative and unspecified otitis media, Acute suppurative otitis media
4.2
6.8
18
43
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.7
6.8
156
1003
H50.31
ICD-10 Finland
Intermittent exotropia
3.2
6.8
27
86
F98.2
ICD-10 Finland
Feeding disorder of infancy and childhood
4.0
6.7
19
48
F70.0
ICD-10 Finland
Mild mental retardation, With the statement of no, or minimal, impairment of behaviour
4.0
6.7
19
48
Z94.1
ICD-10 Finland
Heart transplant status
9.2
6.7
13
14
FXF00
NOMESCO Finland
Decannulation after ECHLA or ECLA
39.6
6.7
8
*
TFC20
NOMESCO Finland
Catheterisation of both sides of heart
39.6
6.7
8
*
H65.3
ICD-10 Finland
Chronic mucoid otitis media
2.0
6.7
75
389
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.2
6.7
53
241
Q76.30
ICD-10 Finland
Hemivertebra fusion or failure of segmentation with scoliosis
22.3
6.6
9
*
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.3
6.6
50
223
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.7
6.5
139
877
WW804
NOMESCO Finland
Transfer from treating institution to higher-Level care, accompanied by doctor
5.4
6.5
18
33
EBA15
NOMESCO Finland
Extraction of multiple teeth
2.5
6.5
39
156
M01AE01
ATC
ibuprofen; systemic, rectal
0.7
6.5
442
5061
TJD00
NOMESCO Finland
Insertion of nasogastric or naso-gastroduodenal tube
3.2
6.4
25
79
ZX108
NOMESCO Finland
Inhalation
4.1
6.4
17
41
AJ2
HP
Reconstruction of the ascending aorta
69.0
6.4
7
*
AB2
HP
AVR bio, stent
69.0
6.4
7
*
Q23.9
ICD-10 Finland
Congenital malformation of aortic and mitral valves, unspecified
+∞
6.2
6
*
AF1
HP
Surgery of congenital heart defect
+∞
6.2
6
*
Q21.18
ICD-10 Finland
Other spedified atrial septal defect
+∞
6.2
6
*
FDA96
NOMESCO Finland
Other operation for HLHS
+∞
6.2
6
*
FLE00
NOMESCO Finland
Excision of subvalvular membrane of left ventricle
+∞
6.2
6
*
FBE20
NOMESCO Finland
Reconstruction of pulmonary artery using tube graft
+∞
6.2
6
*
Q20.5
ICD-10 Finland
Discordant atrioventricular connection
+∞
6.2
6
*
FAE96
NOMESCO Finland
Other connection to pulmonary artery from superior vena cava
+∞
6.2
6
*
FMC20
NOMESCO Finland
Suture of leaflet of aortic valve
+∞
6.2
6
*
FLE10
NOMESCO Finland
Myotomy or myectomy of left ventricle for outlet obstruction
+∞
6.2
6
*
FBJ00
NOMESCO Finland
Anastomosis to pulmonary artery from subclavian artery
+∞
6.2
6
*
FDH10
NOMESCO Finland
Reconstruction of interrupted or hypoplastic aortic arch using patch
+∞
6.2
6
*
7451B
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Transposition of great vessels[DOUBLE OUTLET RIGHT VENTRICLE]
+∞
6.2
6
*
FDB20
NOMESCO Finland
Arterial switch operation for other congenital heart defect
+∞
6.2
6
*
R03BB01
ATC
ipratropium bromide; inhalant
3.6
6.1
20
56
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
2.0
6.0
64
326
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
427
918
8.59
209.12
7.5
3.5
1163.21
1057.31
ng/l
0.23
400
757
235
261
12.06
198.29
5.0
5.0
193.85
202.81
ng/l
0.08
215
233
476
1799
4.90
109.57
31.4
8.6
1.74
1.15
inr
10.94
101
537
338
1359
3.48
63.01
3.2
3.1
—
—
—
0
0
246
806
3.87
62.72
6.6
3.2
2518.65
354.71
ng/l
3.19
204
500
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
80
135
6.34
45.08
24.2
11.9
0.33
0.33
u/ml
0.06
50
83
447
2462
2.76
43.26
3.7
3.1
—
—
—
0
0
228
915
3.01
39.84
11.2
10.0
0.83
0.81
mmol/l
0.75
223
874
114
293
4.28
39.57
2.3
2.2
17.19
8.19
ug/l
2.97
108
253
132
468
3.11
27.88
26.1
10.1
0.51
0.53
mmol/l
0.01
115
369
160
632
2.85
27.86
13.9
9.7
105.92
104.80
mmol/l
2.06
160
632
36
13
28.36
26.62
6.0
12.2
—
—
—
0
0
87
247
3.75
26.02
33.0
13.4
—
—
—
0
0
746
6079
3.78
23.98
25.2
14.3
139.42
139.50
mmol/l
0.53
736
5908
744
6082
3.64
23.15
24.9
14.3
3.99
3.96
mmol/l
1.35
733
5886
59
145
4.23
21.47
1.4
1.4
—
—
—
0
0
501
3500
2.07
21.42
13.3
6.7
6.17
6.32
mmol/l
1.08
476
3249
83
261
3.36
21.19
8.5
11.8
0.69
0.60
%
1.71
83
261
404
2645
2.00
20.33
9.5
7.9
23.84
18.93
umol/l
1.59
382
2489
179
862
2.33
20.14
3.0
2.9
2.49
2.47
g/l
0.19
173
815
170
809
2.35
19.61
3.0
3.0
21.10
22.67
%
0.91
156
751
220
1178
2.14
18.98
12.8
10.7
1.29
1.27
mmol/l
0.33
214
1122
172
856
2.23
17.69
2.2
2.1
—
—
—
0
0
246
1408
2.03
17.55
4.0
3.0
70.90
34.15
ng/l
1.29
161
807
139
658
2.30
16.01
2.1
2.0
—
—
—
0
0
212
1187
2.02
15.86
4.6
3.4
1.92
1.53
mg/l
0.51
148
891
139
663
2.28
15.71
2.2
2.1
—
—
—
0
0
226
1355
1.88
13.54
3.2
2.5
435.84
309.41
u/l
0.86
219
1292
402
2869
1.75
13.37
21.1
11.6
1.20
1.23
mmol/l
10.02
388
2715
202
1173
1.92
13.31
9.4
10.4
1.25
1.23
mmol/l
0.04
169
931
292
1938
1.75
12.28
4.5
4.6
42.08
33.25
u/l
1.05
284
1850
737
6438
2.45
11.81
18.9
12.2
27.89
23.03
mg/l
3.14
597
4664
415
3056
1.69
11.76
16.6
11.4
1.21
1.22
mmol/l
5.49
377
2776
190
1137
1.84
11.18
14.1
10.3
5.17
4.99
kpa
3.49
185
1095
188
1123
1.84
11.12
14.1
10.4
1.99
0.67
mmol/l
11.56
161
780
311
2181
1.65
10.22
9.0
7.3
36.18
36.88
g/l
1.15
295
2078
705
6131
2.03
10.08
25.6
16.4
14.21
13.88
%
1.15
698
6051
238
1569
1.69
9.85
3.1
2.9
3.09
2.76
mg/l
1.34
214
1382
511
4077
1.63
9.74
7.6
6.7
99.43
105.75
u/l
1.03
489
3835
44
161
2.78
8.66
2.2
3.9
—
—
—
0
0
306
2236
1.55
7.98
3.9
4.2
—
—
—
0
0
534
4409
1.56
7.90
14.1
9.6
92.91
92.93
ml/min/173m2
0.00
439
3321
55
236
2.38
7.86
2.2
2.2
—
—
—
0
0
43
167
2.61
7.57
1.7
2.1
—
—
—
0
0
54
237
2.32
7.34
2.2
2.3
—
—
—
0
0
45
183
2.50
7.23
1.5
2.1
—
—
—
0
0
495
4116
1.47
6.32
10.5
11.5
3.89
3.64
e9/l
1.63
443
3464
133
845
1.65
6.07
5.8
5.9
1.58
1.45
%
0.89
125
796
49
226
2.20
5.97
1.7
1.4
—
—
—
0
0
49
226
2.20
5.97
1.7
1.4
—
—
—
0
0
272
2038
1.47
5.89
3.7
4.2
20.14
70.51
e6/l
0.90
222
1530
41
178
2.33
5.76
2.4
2.3
—
—
—
0
0
41
178
2.33
5.76
2.4
2.3
—
—
—
0
0
38
160
2.40
5.71
1.6
2.0
—
—
—
0
0
189
1324
1.52
5.66
2.9
3.3
4.64
5.44
e6/l
0.49
177
1165
65
341
1.95
5.64
3.1
2.5
70.07
74.76
ml/min/173m2
0.33
27
126
450
3730
1.42
5.48
7.9
9.0
29.14
33.87
%
12.69
437
3603
371
2977
1.41
5.42
3.8
3.2
80.84
81.12
ug/l
0.01
355
2807
254
1907
1.45
5.35
3.5
4.1
0.19
0.28
e6/l
0.81
202
1410
442
3672
1.40
5.19
7.9
8.9
55.22
50.79
%
9.95
429
3546
128
838
1.59
5.15
5.5
6.0
9.27
7.17
umol/l
0.83
117
700
42
194
2.19
5.13
1.6
2.1
1.31
1.33
g/l
0.04
27
169
782
7339
2.58
5.11
29.0
18.1
246.38
263.73
e9/l
10.92
767
7039
43
201
2.16
5.10
2.4
2.3
—
—
—
0
0
43
201
2.16
5.10
2.4
2.3
—
—
—
0
0
782
7340
2.58
5.09
32.8
18.5
39.49
40.04
%
2.07
751
7003
140
939
1.56
5.07
1.5
1.4
23.56
21.10
nmol/l
1.00
124
809
782
7346
2.55
4.97
29.0
18.0
4.51
4.59
e12/l
3.90
763
7023
782
7351
2.52
4.87
30.8
18.2
132.39
134.88
g/l
4.12
775
7262
13
25
5.17
4.70
1.5
1.4
24210.00
23510.67
e6/l
—
8
15
22
78
2.82
4.67
2.2
1.7
—
—
—
0
0
18
57
3.15
4.63
1.8
2.1
—
—
—
0
0
14
30
4.64
4.61
1.9
1.2
—
—
—
0
0
206
1529
1.43
4.51
3.5
2.9
59.87
60.51
u/l
0.05
193
1426
9
11
8.10
4.51
2.8
4.0
—
—
—
0
0
58
320
1.84
4.36
3.2
4.9
1.22
1.23
mmol/l
0.30
53
282
87
542
1.64
4.28
7.3
7.6
65.55
58.34
ng/l
0.59
79
520
26
106
2.45
4.24
4.5
2.9
17.63
17.38
%
0.09
15
65
63
360
1.78
4.23
2.2
1.7
—
—
—
0
0
16
50
3.18
4.21
4.3
2.8
4.06
4.03
mmol/l
0.09
16
50
28
119
2.36
4.18
1.9
1.5
—
—
—
0
0
57
319
1.81
4.11
1.7
1.8
—
—
—
0
0
110
736
1.54
4.02
1.8
1.6
456.06
18111911.28
pmol/l
0.79
95
646
190
1422
1.41
3.92
4.3
3.5
0.00
0.01
estimate
0.88
67
487
445
3807
1.33
3.81
4.3
4.1
8.60
82.71
e6/l
—
5
42
15
49
3.04
3.69
4.5
2.8
105.33
105.90
mmol/l
0.17
15
49
23
95
2.42
3.68
2.2
1.6
—
—
—
0
0
34
168
2.03
3.56
2.0
3.6
0.25
0.18
e9/l
0.76
26
121
14
40
3.48
3.54
1.1
1.1
85.78
91.37
%
—
9
19
10
21
4.72
3.50
1.9
1.6
—
—
—
0
0
18
70
2.56
3.27
2.1
2.2
—
—
—
0
0
13
38
3.39
3.25
1.2
1.2
—
—
—
0
0
13
39
3.31
3.16
1.4
1.1
69.38
90.17
%
—
8
18
28
136
2.06
3.10
4.1
2.5
139.21
135.11
g/l
0.23
19
106
690
6381
1.42
3.09
11.8
9.9
28.47
27.23
u/l
0.62
671
6182
33
171
1.93
3.06
2.0
3.6
379.04
575.39
e6/l
2.14
26
122
25
117
2.13
3.04
2.3
4.2
57.52
52.74
%
1.08
25
117
23
106
2.16
2.91
1.3
1.2
1.63
2.67
u/ml
—
8
46
23
106
2.16
2.91
1.2
1.2
4.13
3.20
u/ml
0.19
15
54
12
38
3.13
2.79
1.5
1.6
—
—
—
0
0
150
1141
1.36
2.76
4.2
3.9
3687.83
3421.43
umol/l
0.03
134
1034
22
103
2.13
2.70
3.0
3.5
21.11
28.92
mg/l
0.59
16
62
45
699
0.61
2.69
1.0
1.1
—
—
—
0
0
33
181
1.82
2.62
1.4
1.6
—
—
—
0
0
7
15
4.61
2.55
3.4
3.7
4.33
4.55
mmol/l
—
7
15
13
49
2.63
2.53
1.6
2.3
31.69
33.31
pg
0.76
13
49
61
400
1.54
2.50
3.3
2.8
—
—
—
0
0
23
114
2.01
2.46
3.7
5.5
5.00
4.88
kpa
0.37
23
114
421
3707
1.24
2.37
4.1
4.1
48.05
39.44
u/l
1.51
396
3541
29
158
1.83
2.37
1.9
2.0
—
—
—
0
0
82
578
1.44
2.37
1.7
1.6
1122.82
1170.95
nmol/l
0.18
66
442
26
137
1.89
2.35
2.6
1.5
—
—
—
0
0
27
147
1.83
2.22
1.9
1.8
—
—
—
0
0
337
2915
1.23
2.19
3.9
3.4
0.00
0.01
estimate
0.80
72
484
334
2887
1.23
2.19
5.2
4.9
0.00
0.00
estimate
0.50
72
506
21
106
1.97
2.16
1.0
1.1
—
—
—
0
0
332
2882
1.22
2.05
3.9
3.4
0.00
0.00
estimate
0.50
74
508
22
116
1.88
2.01
2.3
3.7
4.20
3.79
e9/l
0.34
22
116
53
356
1.49
1.98
3.3
3.6
4.63
4.92
pmol/l
1.50
47
325
516
4689
1.22
1.98
3.9
3.7
14.87
14.52
pmol/l
2.63
483
4323
15
69
2.15
1.96
1.1
1.2
—
—
—
0
0
15
69
2.15
1.96
1.1
1.2
—
—
—
0
0
154
1235
1.28
1.94
3.1
3.6
0.67
0.76
e6/l
0.26
90
706
63
441
1.44
1.92
9.4
6.1
—
—
—
0
0
8
27
2.92
1.89
1.4
1.6
—
—
—
0
0
7
22
3.14
1.84
1.0
1.3
1.37
1.49
g/l
—
7
22
12
238
0.49
1.73
1.0
1.1
4.17
0.37
u/ml
—
6
121
40
262
1.52
1.71
3.4
3.7
0.06
0.08
e6/l
0.20
40
254
36
526
0.66
1.71
1.5
1.5
—
—
—
0
0
207
2346
0.82
1.71
1.5
1.7
1.08
2.85
u/ml
3.05
44
437
20
109
1.82
1.69
3.5
4.6
26.70
25.28
umol/l
0.40
20
109
20
333
0.58
1.65
2.0
1.4
—
—
—
0
0
20
110
1.80
1.64
1.6
2.0
—
—
—
0
0
240
2060
1.20
1.60
4.0
3.2
—
—
—
0
0
149
1219
1.24
1.59
3.4
3.7
2.79
1.94
e6/l
0.42
86
698
33
211
1.56
1.58
10.8
10.7
254.40
467.29
iu/ml
—
5
35
14
69
2.01
1.57
1.1
1.2
—
—
—
0
0
528
4861
1.19
1.56
4.3
3.8
4.37
4.59
mmol/l
5.64
508
4602
504
4630
1.18
1.50
3.9
3.5
1.26
1.24
mmol/l
0.30
483
4347
7
27
2.56
1.48
1.0
1.6
0.94
1.07
g/l
—
7
27
6
21
2.82
1.47
1.5
1.6
—
—
—
0
0
196
1665
1.20
1.45
3.4
3.3
2.37
2.38
mmol/l
1.04
183
1514
31
447
0.67
1.41
1.0
1.2
4.41
5.83
u/ml
0.42
20
339
0
38
0.00
1.34
0.0
1.2
—
—
—
0
0
23
141
1.62
1.34
1.7
1.8
—
—
—
0
0
6
23
2.57
1.33
1.5
1.5
—
—
—
0
0
31
438
0.68
1.29
1.0
1.2
1.48
1.05
u/ml
0.24
18
313
9
43
2.06
1.27
1.2
1.9
12.76
10.43
umol/l
—
9
43
8
35
2.25
1.25
1.8
3.1
—
—
—
0
0
13
69
1.86
1.22
1.1
1.2
—
—
—
0
0
13
69
1.86
1.22
1.1
1.2
—
—
—
0
0
13
70
1.84
1.18
4.9
5.3
—
—
—
0
0
31
429
0.70
1.17
1.1
1.2
1.73
3.41
u/ml
0.91
24
323
0
32
0.00
1.16
0.0
1.2
—
—
—
0
0
43
317
1.35
1.06
1.7
1.9
—
—
—
0
0
23
329
0.68
1.05
2.3
1.8
—
—
—
0
0
54
413
1.30
1.04
2.2
2.4
5646.80
4259.95
u/l
0.12
20
143
5
22
2.24
1.01
2.0
1.2
364.40
368.12
u/l
—
5
22
28
194
1.43
0.99
1.2
1.2
—
—
—
0
0
21
139
1.49
0.93
3.9
2.4
—
—
—
0
0
34
249
1.35
0.90
4.3
3.8
31.35
36.80
umol/l
1.46
34
232
219
2356
0.88
0.89
2.0
1.9
—
—
—
0
0
520
4880
1.13
0.89
4.6
4.0
2.65
2.78
mmol/l
2.95
499
4571
5
103
0.47
0.89
1.0
1.2
0.02
16.45
u/ml
—
5
94
101
848
1.19
0.88
1.2
1.2
27.06
28.40
iu/ml
0.05
21
242
18
259
0.67
0.88
1.2
1.5
—
—
—
0
0
513
4814
1.12
0.87
4.1
3.7
1.38
1.42
mmol/l
1.61
493
4526
190
1684
1.14
0.83
2.1
1.7
91.01
96.52
pmol/l
0.93
109
856
10
56
1.76
0.83
3.0
1.3
—
—
—
0
0
505
4743
1.12
0.82
4.1
3.4
5.64
5.71
mmol/l
0.77
468
4361
41
314
1.30
0.82
1.8
1.4
—
—
—
0
0
0
24
0.00
0.79
0.0
1.5
—
—
—
0
0
6
33
1.79
0.77
5.2
5.1
—
—
—
0
0
151
1327
1.14
0.76
4.2
3.2
1.02
1.02
kg/l
0.19
18
234
36
448
0.78
0.74
1.4
1.2
—
—
—
0
0
5
24
2.05
0.73
1.4
1.3
—
—
—
0
0
5
24
2.05
0.73
1.4
1.3
—
—
—
0
0
75
625
1.20
0.73
2.6
2.1
—
—
—
0
0
25
181
1.37
0.73
1.3
1.3
276.27
349.08
ug/g
0.85
15
102
15
98
1.51
0.73
1.9
1.3
—
—
—
0
0
20
271
0.72
0.73
1.0
1.0
-1.87
-2.50
mmol/l
—
6
68
20
271
0.72
0.73
1.0
1.0
20.15
19.49
mmol/l
0.67
20
266
20
271
0.72
0.73
1.0
1.0
7.21
7.27
kpa
0.06
20
235
6
105
0.56
0.73
1.0
1.3
1.67
8.09
u/ml
—
6
95
7
38
1.81
0.73
1.3
1.6
—
—
—
0
0
17
234
0.71
0.69
1.4
1.4
—
—
—
0
0
17
234
0.71
0.69
1.4
1.4
—
—
—
0
0
20
267
0.73
0.68
1.0
1.0
3.07
3.28
kpa
0.53
20
232
17
233
0.71
0.67
1.4
1.4
—
—
—
0
0
17
233
0.71
0.67
1.4
1.4
—
—
—
0
0
28
210
1.32
0.67
1.3
2.6
—
—
—
0
0
39
473
0.80
0.67
1.2
1.3
1.22
3.15
u/ml
0.97
24
343
32
397
0.78
0.66
1.2
1.2
—
—
—
0
0
211
2236
0.90
0.66
1.7
1.7
1.90
1.78
g/l
0.53
136
1173
107
1179
0.87
0.64
2.4
2.2
—
—
—
0
0
30
373
0.78
0.63
1.4
1.3
—
—
—
0
0
13
86
1.49
0.61
3.0
1.2
—
—
—
0
0
8
49
1.61
0.61
1.1
1.3
157.57
194.97
pmol/l
—
8
49
577
5500
1.10
0.60
4.7
4.2
2.00
1.92
mu/l
0.81
543
5126
15
103
1.44
0.60
1.1
1.8
5.07
3.60
umol/l
1.05
15
94
0
21
0.00
0.60
0.0
1.6
—
—
—
0
0
77
862
0.86
0.58
4.0
3.7
23.99
21.63
%
0.54
36
359
6
34
1.74
0.58
2.7
2.3
38100.00
41823.68
ug/l
—
6
34
0
23
0.00
0.58
0.0
1.3
—
—
—
0
0
81
697
1.16
0.57
2.3
2.6
2.41
2.44
mmol/l
1.02
66
595
8
120
0.65
0.55
1.1
1.3
—
—
—
0
0
14
97
1.42
0.54
2.0
1.3
—
—
—
0
0
150
1351
1.11
0.53
1.9
1.8
1.42
1.34
mmol/l
0.42
137
1187
18
232
0.76
0.52
1.1
1.1
—
—
—
0
0
20
253
0.77
0.50
1.4
1.4
3.07
3.47
mg/l
0.14
13
181
7
44
1.57
0.49
1.9
3.0
33.46
2.98
nmol/l
—
7
44
268
2490
1.08
0.49
3.8
3.1
75.28
72.22
nmol/l
1.04
247
2319
18
229
0.77
0.48
3.8
2.4
29.41
35.18
u/ml
0.19
18
218
20
250
0.78
0.47
1.1
1.1
3.40
9.86
u/ml
2.98
13
149
18
228
0.77
0.47
1.3
4.2
7652.31
980.74
e6/l
0.47
13
170
18
228
0.77
0.47
1.3
4.2
9.85
7.15
e6/l
0.14
13
165
10
139
0.70
0.46
1.2
1.3
—
—
—
0
0
7
50
1.38
0.44
1.0
1.8
—
—
—
0
0
7
50
1.38
0.44
1.0
1.8
—
—
—
0
0
7
50
1.38
0.44
1.0
1.8
—
—
—
0
0
52
444
1.16
0.43
2.5
2.0
6.25
6.74
u/l
0.13
41
282
22
268
0.80
0.43
1.1
1.1
11.97
8.90
u/ml
0.21
16
174
111
1186
0.90
0.42
2.4
3.1
143.38
104.82
ug/g
0.24
94
967
76
829
0.89
0.42
1.3
1.2
16.09
7.44
u/ml
0.38
28
300
0
16
0.00
0.41
0.0
1.2
—
—
—
0
0
8
58
1.36
0.41
1.4
1.2
0.68
1.38
promille
—
8
47
0
17
0.00
0.40
0.0
3.3
—
—
—
0
0
460
4385
1.07
0.40
5.3
4.7
37.22
38.50
mmol/mol
2.49
436
4136
0
18
0.00
0.39
0.0
1.0
—
40.75
—
0
8
0
18
0.00
0.39
0.0
1.2
—
—
—
0
0
0
18
0.00
0.39
0.0
1.0
—
523.67
—
0
9
5
34
1.45
0.39
1.0
1.2
219.00
588.29
u/l
—
5
28
19
148
1.27
0.39
3.5
1.7
—
—
—
0
0
12
87
1.36
0.38
2.4
1.3
—
—
—
0
0
10
70
1.41
0.38
1.4
4.2
33.00
155.24
umol/l
—
5
35
26
212
1.21
0.37
1.2
1.1
—
—
—
0
0
57
498
1.13
0.36
1.4
1.3
126.50
150.87
iu/ml
0.16
18
170
5
76
0.64
0.36
1.0
1.3
—
—
—
0
0
5
78
0.63
0.35
1.6
1.8
—
—
—
0
0
84
753
1.11
0.35
2.8
2.2
—
—
—
0
0
6
42
1.40
0.35
1.5
1.3
—
—
—
0
0
14
175
0.78
0.35
1.1
1.3
—
—
—
0
0
16
124
1.27
0.34
1.3
1.2
—
1.17
—
0
7
42
467
0.88
0.33
1.4
1.5
—
—
—
0
0
26
215
1.19
0.33
1.2
1.1
—
—
—
0
0
6
46
1.28
0.32
3.0
1.9
675.50
1192.02
u/ml
—
6
46
6
46
1.28
0.32
1.3
1.5
—
—
—
0
0
74
792
0.91
0.31
1.3
1.5
—
—
—
0
0
7
53
1.30
0.30
1.0
1.3
—
—
—
0
0
8
105
0.74
0.29
1.3
1.6
—
—
—
0
0
8
63
1.25
0.27
1.1
1.3
—
—
—
0
0
454
4358
1.05
0.27
4.9
4.4
10.30
8.91
mm/h
1.28
430
4066
6
80
0.73
0.24
1.2
4.1
—
—
—
0
0
6
80
0.73
0.24
1.2
4.1
—
—
—
0
0
38
335
1.12
0.23
3.7
4.4
13.57
20.64
ug/l
0.17
27
261
33
362
0.89
0.23
1.8
1.8
—
—
—
0
0
50
449
1.10
0.22
2.6
2.0
15.62
13.53
iu/l
0.27
42
310
5
40
1.23
0.22
1.2
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
15.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
5.86
—
0
5
0
11
0.00
0.21
0.0
19.7
—
—
—
0
0
0
11
0.00
0.21
0.0
19.8
—
24.27
—
0
11
0
12
0.00
0.21
0.0
5.6
—
3.63
—
0
12
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
42
451
0.91
0.21
3.8
3.6
32.48
31.87
%
0.13
33
325
5
42
1.17
0.21
7.0
8.8
—
—
—
0
0
6
47
1.25
0.20
1.0
1.2
226.17
201.94
iu/ml
—
6
47
0
14
0.00
0.20
0.0
1.4
—
316.38
—
0
8
6
50
1.18
0.19
1.2
1.2
—
—
—
0
0
6
51
1.16
0.19
1.2
1.2
—
—
—
0
0
6
51
1.16
0.19
4.3
7.3
—
—
—
0
0
6
51
1.16
0.19
3.0
7.2
—
—
—
0
0
125
1280
0.95
0.19
2.4
2.4
—
—
—
0
0
15
126
1.17
0.17
1.1
1.2
—
—
—
0
0
8
68
1.16
0.16
1.0
1.3
—
—
—
0
0
583
5661
1.04
0.16
3.7
3.7
—
—
—
0
0
8
71
1.11
0.16
1.1
1.3
—
—
—
0
0
39
354
1.08
0.15
2.5
2.0
227.13
173.94
u/ml
0.46
23
167
23
203
1.11
0.15
1.4
1.7
36.48
39.17
nmol/l
0.24
23
198
7
84
0.82
0.14
1.0
1.1
—
—
—
0
0
14
119
1.16
0.14
1.1
1.9
—
—
—
0
0
7
87
0.79
0.14
1.0
1.1
—
—
—
0
0
7
87
0.79
0.14
1.0
1.1
—
—
—
0
0
39
358
1.07
0.12
2.4
2.0
—
—
—
0
0
24
257
0.91
0.12
1.2
1.3
333.50
250.82
miu/ml
—
10
133
21
224
0.92
0.10
1.3
1.6
—
—
—
0
0
5
44
1.12
0.10
31.8
19.5
1571.00
1349.27
nmol/l
—
5
44
5
45
1.09
0.09
1.0
1.3
2.02
1.18
nmol/l
—
5
39
59
602
0.96
0.09
3.3
2.4
29.68
31.44
u/l
0.20
53
495
176
1695
1.02
0.08
4.0
4.1
7.08
8.03
mmol/l
1.88
161
1516
5
61
0.80
0.08
7.4
10.0
—
—
—
0
0
5
62
0.79
0.08
1.0
1.1
—
—
—
0
0
13
141
0.90
0.08
1.4
1.8
149.46
216.11
pmol/l
1.46
13
133
19
172
1.09
0.08
1.6
1.9
—
—
—
0
0
61
620
0.96
0.08
3.0
2.6
1.15
0.69
ug/l
0.77
38
365
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
8
76
1.03
0.07
1.0
1.3
—
—
—
0
0
13
140
0.91
0.07
1.5
1.5
—
—
—
0
0
20
183
1.07
0.07
1.5
1.5
—
—
—
0
0
8
91
0.86
0.06
1.1
1.3
77.38
76.59
%
—
8
91
27
252
1.05
0.05
1.3
1.3
—
—
—
0
0
10
108
0.91
0.05
2.3
2.0
—
—
—
0
0
11
117
0.92
0.04
1.3
1.6
—
—
—
0
0
10
107
0.92
0.04
1.2
1.3
104.50
69.65
pmol/l
—
10
102
115
1116
1.01
0.02
4.1
4.0
13.06
11.89
mg/mmol
0.07
78
762
31
313
0.97
0.02
1.5
1.4
—
—
—
0
0
10
105
0.93
0.02
1.3
1.6
—
—
—
0
0
17
160
1.04
0.01
2.9
1.9
2.58
4.79
iu/l
—
8
54
20
190
1.03
0.01
1.9
1.7
—
—
—
0
0
21
210
0.98
0.00
1.7
1.7
—
—
—
0
0
10
98
1.00
0.00
1.2
1.1
—
—
—
0
0
111
1091
1.00
0.00
4.0
4.0
1.85
2.08
ug/l
0.27
100
989
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
7
74
0.93
-0.00
1.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
227.33
—
0
6
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
132.67
—
0
6
9
91
0.97
-0.00
1.4
1.7
—
—
—
0
0
6
67
0.88
-0.00
1.2
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
69
1.00
-0.00
1.0
1.1
—
—
—
0
0
5
51
0.96
-0.00
1.6
7.5
—
44.56
—
0
9
Mortality – FinRegistry
↥Association
Association between endpoint Q17_CONGEN_MALFO_GREAT_ARTERIES and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CONGEN_MALFO_GREAT_ARTERIES | 3.101 [2.4, 4.0] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.421 |
During the follow-up period (1.1.1998 — 31.12.2019), 246 out of 5292 females with Q17_CONGEN_MALFO_GREAT_ARTERIES died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CONGEN_MALFO_GREAT_ARTERIES | 2.705 [2.21, 3.31] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 278 out of 5278 males with Q17_CONGEN_MALFO_GREAT_ARTERIES died.
Mortality risk
Mortality risk for people of age
years, who have Q17_CONGEN_MALFO_GREAT_ARTERIES.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.375% | 0.496% |
| 5 | 1.882% | 2.813% |
| 10 | 4.585% | 7.174% |
| 15 | 8.942% | 13.541% |
| 20 | 15.7% | 22.229% |
Relationships between endpoints
↥Index endpoint: Q17_CONGEN_MALFO_GREAT_ARTERIES – Congenital malformations of great arteries
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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