No definition available.
Congenital malformations of great arteries
DOID EFO Endpoint Browser PheWeb
Q17_CONGEN_MALFO_GREAT_ARTERIES
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
797 |
4. Check minimum number of eventsNone |
797 |
5. Include endpointsNone |
797 |
6. Filter based on genotype QC (FinnGen only) |
797 |
Control definitions (FinnGen only)
- Control exclude
- Q17_CONGEN_MALFO_CIRCULATO_SYSTEM
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- Q2
- Name in latin
- Malformationes congenitae arteriarum magnarum
Similar endpoints
↥List of similar endpoints to
Congenital malformations of great arteries
based on the number of shared cases.
Similar with more cases:
- Congenital malformations of heart and great arteries
- Congenital malformations of the circulatory system
- Congenital malformations, deformations and chromosomal abnormalities
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 11820 | 5910 | 5895 |
| Only index persons | 7116 | 3524 | 3592 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.17 | 0.17 | 0.16 |
| Only index persons | 0.13 | 0.13 | 0.14 |
| Median age at first event (years) | |||
| Whole population | 0.49 | 0.43 | 0.38 |
| Only index persons | 3.34 | 3.12 | 3.56 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 797 | 411 | 386 |
| Unadjusted period prevalence (%) | 0.15 | 0.14 | 0.17 |
| Median age at first event (years) | 13.14 | 12.71 | 13.59 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 710
- Matched controls
- 6999
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q25.1
ICD-10 Finland
Coarctation of aorta
+∞
323.0
308
*
Q25.0
ICD-10 Finland
Patent ductus arteriosus
+∞
298.4
266
*
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
14.0
197.7
411
627
Q23.11
ICD-10 Finland
Bicuspid aortic valve
1608.9
140.9
133
*
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
37.3
140.7
182
64
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
11.5
132.9
280
375
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
23.3
127.8
190
108
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
29.3
125.5
173
76
XF400
NOMESCO Finland
ECG with 12 standard connections
8.1
115.8
316
633
Q21.08
ICD-10 Finland
Other specifed ventricular septal defect
+∞
98.8
93
*
74719
ICD-8 Finland
Other congenital anomalies of circulatory system, Coarctation of aorta
+∞
91.2
86
*
Q21.10
ICD-10 Finland
Persistent ostium secundum
+∞
89.0
84
*
201
Kela drug reimbursment
Chronic cardiac insufficiency
24.6
88.7
128
62
FM2CE
NOMESCO Finland
NA
12.6
87.4
166
165
Q21.00
ICD-10 Finland
Multiple ventricular septal defect
+∞
86.9
82
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.9
85.2
412
1528
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
23.5
82.1
120
60
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
10.3
77.6
164
198
B01AA03
ATC
warfarin; systemic
8.4
77.3
187
285
7471A
ICD-9 Finland
Other congenital anomalies of circulatory system, Coarctation of aorta[COARCTATIO AORTAE]
+∞
70.7
67
*
XF600
NOMESCO Finland
Bloodpressure measurement
7.7
70.0
180
297
Q21.09
ICD-10 Finland
Ventricular septal defect NOS
+∞
68.5
65
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
8.3
66.3
159
234
TFC99
NOMESCO Finland
Catheterisation of heart with other procedure
72.7
64.3
73
11
FM1DG
NOMESCO Finland
Very extensive MRI examination of heart with high intesity magnet
58.0
62.9
74
14
31
HP
Congenital heart failure surgery
654.7
62.5
61
*
61
HP
Catheterization and pressure measurement of the left side of the heart
71.5
58.0
66
10
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
5.0
56.8
214
557
XF404
NOMESCO Finland
Ambulatory ECG
7.6
56.3
143
226
XF402
NOMESCO Finland
ECG with work load test
7.9
55.7
137
206
GAE10
NOMESCO Finland
Closure of previous incision of chest wall
203.3
55.5
57
*
I35.0
ICD-10 Finland
Aortic (valve) stenosis
18.3
55.1
87
53
TPH07
NOMESCO Finland
Cathetrisation of artery
6.1
54.9
167
337
C03CA01
ATC
furosemide; systemic
5.3
52.7
182
426
ZXD10
NOMESCO Finland
Scheduled procedure
3.4
50.4
387
1838
ZXE20
NOMESCO Finland
More than three and less than five hours
4.8
50.3
192
499
Q23.0
ICD-10 Finland
Congenital stenosis of aortic valve
+∞
49.3
47
*
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
43.0
48.4
60
15
Q21.11
ICD-10 Finland
Paten or persistent foramen ovale
+∞
48.2
46
*
ZXE10
NOMESCO Finland
More than one and less than three hours
3.3
48.0
342
1520
I71.2
ICD-10 Finland
Thoracic aortic aneurysm, without mention of rupture
27.4
47.8
66
26
Q25.3
ICD-10 Finland
Stenosis of aorta
+∞
47.2
45
*
FDE32
NOMESCO Finland
Percutaneous transluminal closure of patent ductus arteriosus
+∞
47.2
45
*
Z2221
NOMESCO Finland
Medical doctor
3.3
44.8
304
1284
WX408
NOMESCO Finland
General anesthesy, balanced
3.2
43.6
316
1394
62
HP
Catheterization and pressure measurement of the right side of the heart
230.8
43.2
44
*
C03DA01
ATC
spironolactone; oral
7.1
42.5
110
175
XFE00
NOMESCO Finland
Epicardial ultrasonography
18.4
41.6
65
38
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
4.9
41.0
149
360
Q25.6
ICD-10 Finland
Stenosis of pulmonary artery
+∞
40.8
39
*
Q25.40
ICD-10 Finland
Aortic hypoplasia
+∞
40.8
39
*
Q20.3
ICD-10 Finland
Discordant ventriculoarterial connection
+∞
39.8
38
*
Q25.48
ICD-10 Finland
Other congenital malformations of the aorta
+∞
39.8
38
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.2
39.0
270
1129
Q25.41
ICD-10 Finland
Persistent right-sided aortic arch
+∞
38.7
37
*
FM1CG
NOMESCO Finland
Extensive examination of hear with high intensity magnet
42.2
38.7
48
12
ZXE30
NOMESCO Finland
More than five and less than seven hours
6.1
37.3
109
203
XF622
NOMESCO Finland
Measurement of minute volume of heart
71.3
36.1
41
6
FXA10
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia at concurrent surgical procedure
370.3
36.1
36
*
FBE32
NOMESCO Finland
Percutaneous transluminal angioplasty of pulmonary artery
+∞
34.5
33
*
Q21.30
ICD-10 Finland
Tetralogy of Fallot
+∞
32.4
31
*
Q25.78
ICD-10 Finland
Other congenital malformations of pulmonary artery
+∞
32.4
31
*
FN1BB
NOMESCO Finland
Contrast angiography of heart and/or coronary arteries after bypass surgery
24.8
32.0
45
19
FMD00
NOMESCO Finland
Replacement of aortic valve using mechanical prosthesis
117.2
31.8
34
*
Q23.10
ICD-10 Finland
Congenital insufficiency of aortic valve
+∞
31.3
30
*
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
40.6
31.3
39
10
Z98.8
ICD-10 Finland
Other specified postsurgical states
21.0
31.0
46
23
PD5CG
NOMESCO Finland
Extensive MRI examination of thoracal and abdominal aortta with high intensity magnet
113.6
30.7
33
*
C01AA05
ATC
digoxin; systemic
9.7
30.7
64
71
Q22.1
ICD-10 Finland
Congenital pulmonary valve stenosis
+∞
30.3
29
*
I35.2
ICD-10 Finland
Aortic (valve) stenosis with insufficiency
20.5
30.2
45
23
C07AB07
ATC
bisoprolol; oral
2.8
28.6
235
1056
ZXE40
NOMESCO Finland
More than seven and less than nine hours
8.3
27.0
61
78
PD5DG
NOMESCO Finland
Very extensive MRI examination of thoracal and abdominal aortta with high intensity magnet
277.2
26.8
27
*
WX402
NOMESCO Finland
General anaesthesia
2.8
26.2
201
858
WX872
NOMESCO Finland
Intensive care
7.4
26.1
64
93
74709
ICD-8 Finland
Other congenital anomalies of circulatory system, Patent ductus arteriosus
+∞
26.1
25
*
WX882
NOMESCO Finland
High dependency care
3.8
25.7
119
352
FBE10
NOMESCO Finland
Expansion or reconstruction of pulmonary artery using patch
+∞
25.0
24
*
ZXD05
NOMESCO Finland
Urgent procedure
2.5
24.1
251
1266
FBE35
NOMESCO Finland
Percutaneous transluminal angioplasty of pulmonary artery with insertion of stent
+∞
24.0
23
*
Z3231
NOMESCO Finland
Registered nurse
2.3
23.7
301
1678
205
Kela drug reimbursment
Chronic hypertension
3.2
23.7
139
493
Q21.0
ICD-10 Finland
Ventricular septal defect
+∞
22.9
22
*
5513
FHL
Coarctation resection, plastic or bypass
+∞
22.9
22
*
FDF05
NOMESCO Finland
Percutaneous transluminal occlusion of aorto-pulmonary collaterals
+∞
21.9
21
*
FHB50
NOMESCO Finland
Transatrial closure of VSD using patch
+∞
21.9
21
*
K83
ICPC
Heart valve disease NOS
39.5
21.7
27
7
R4110
NOMESCO Finland
Physiotherapy
2.4
21.3
235
1208
FJF20
NOMESCO Finland
Replacement of pulmonary valve using homograft
+∞
20.8
20
*
Q20.1
ICD-10 Finland
Double outlet right ventricle
+∞
20.8
20
*
FDJ00
NOMESCO Finland
End to end reconstruction of aorta for coarctation
+∞
20.8
20
*
FDJ42
NOMESCO Finland
Percutaneous transluminal angioplasty of thoracic aorta in coarctation
+∞
20.8
20
*
Q24.4
ICD-10 Finland
Congenital subaortic stenosis
+∞
20.8
20
*
Q23.4
ICD-10 Finland
Hypoplastic left heart syndrome
+∞
20.8
20
*
I71.9
ICD-10 Finland
Aortic aneurysm of unspecified site, without mention of rupture
33.2
20.2
26
8
C07AB02
ATC
metoprolol; systemic
3.3
20.1
111
374
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
3.6
20.0
98
302
FN1CC
NOMESCO Finland
Very extensive angiography of heart and/or coronary arteries
21.2
19.9
29
14
FFC22
NOMESCO Finland
Percutaneous transluminal closure of ostium secundum type ASD
+∞
19.8
19
*
Q20.48
ICD-10 Finland
Single ventricle
+∞
19.8
19
*
XF620
NOMESCO Finland
Examination of circulation with color method
106.6
19.5
21
*
FCA60
NOMESCO Finland
Resection of aortic root and ascending aorta with reimplantation of coronary arteries and use of composite graft with mechanical valve prosthesis
106.6
19.5
21
*
RS224
NOMESCO Finland
NA
10.9
18.9
36
34
WX704
NOMESCO Finland
Intubation
4.2
18.9
74
187
I37.1
ICD-10 Finland
Pulmonary valve insufficiency
+∞
18.7
18
*
FXA20
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia and circulatory arrest at concurrent surgical procedure
+∞
18.7
18
*
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
3.9
18.7
80
220
G04BE03
ATC
sildenafil; oral
12.6
18.6
33
27
I50.9
ICD-10 Finland
Heart failure, unspecified
4.7
18.5
64
143
C01BD01
ATC
amiodarone; systemic
10.9
17.9
34
32
XQ903
NOMESCO Finland
Production of other scan or drawing
53.2
17.9
21
*
I48
ICD-10 Finland
Atrial fibrillation and flutter
3.4
17.8
93
301
ZXE00
NOMESCO Finland
One hour or less
2.0
17.7
327
2071
FDA00
NOMESCO Finland
Aortoplasty and aorto-pulmonary shunt for HLHS
+∞
17.7
17
*
Q26.1
ICD-10 Finland
Persistent left superior vena cava
+∞
17.7
17
*
Q25.9
ICD-10 Finland
Congenital malformation of great arteries, unspecified
+∞
17.7
17
*
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
6.0
17.6
49
85
PD5BD
NOMESCO Finland
Extensive CT of aorta
15.3
16.6
27
18
WX892
NOMESCO Finland
Monitored bed care
3.3
16.4
87
284
FMD10
NOMESCO Finland
Replacement of aortic valve using biological prosthesis
20.4
16.4
24
12
O99.4
ICD-10 Finland
Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium
40.5
16.3
20
5
TFP20
NOMESCO Finland
Cardiodefibrillation
5.2
15.9
50
101
74639
ICD-8 Finland
Congenital anomalies of heart, Defectus septi ventriculorum
+∞
15.6
15
*
Q25.8
ICD-10 Finland
Other congenital malformations of great arteries
+∞
15.6
15
*
FDE10
NOMESCO Finland
Ligature of patent ductus arteriosus
+∞
15.6
15
*
Q21.19
ICD-10 Finland
Atrial septal defect NOS
+∞
15.6
15
*
Q23.3
ICD-10 Finland
Congenital mitral insufficiency
+∞
15.6
15
*
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
7.0
15.5
38
56
TPH04
NOMESCO Finland
Cathetrisation of vein
2.4
15.3
153
731
UGC02
NOMESCO Finland
Rigid bronchoscopy
9.9
14.7
29
30
Q22.0
ICD-10 Finland
Pulmonary valve atresia
+∞
14.6
14
*
Q21.32
ICD-10 Finland
Pulmonary atresia with Fallot ventricular septal defect
+∞
14.6
14
*
PC1BD
NOMESCO Finland
Extensive CT of thoracic aorta
150.9
14.4
15
*
7470A
ICD-9 Finland
Other congenital anomalies of circulatory system, Patent ductus arteriosus
150.9
14.4
15
*
PD5BG
NOMESCO Finland
MRI examination of thoracal and abdominal aortta with high intensity magnet
150.9
14.4
15
*
FC1AC
NOMESCO Finland
Angiography of thoracal aortta
36.3
14.4
18
5
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
7.4
14.0
33
46
ZXE50
NOMESCO Finland
More than nine and less than 12 hours
7.4
14.0
33
46
XF640
NOMESCO Finland
NA
8.5
14.0
30
36
FFC00
NOMESCO Finland
Suture of ostium secundum type ASD
+∞
13.5
13
*
I37.0
ICD-10 Finland
Pulmonary valve stenosis
+∞
13.5
13
*
7454B
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Ventricular septal defect[DEFECTUS SEPTI VENTRICULORUM SIMPLEX]
+∞
13.5
13
*
FBJ10
NOMESCO Finland
Anastomosis to pulmonary artery from subclavian artery with interposition graft
+∞
13.5
13
*
FJE42
NOMESCO Finland
Percutaneous transluminal expansion of pulmonary valve
+∞
13.5
13
*
Q25.21
ICD-10 Finland
Interrupted aortic arch
+∞
13.5
13
*
Q25.70
ICD-10 Finland
Aneurysm, congenital of pulmonary artery
+∞
13.5
13
*
Q21.21
ICD-10 Finland
Atrioventricular duct
+∞
13.5
13
*
1EA01
NOMESCO Finland
NA
140.6
13.4
14
*
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
6.5
13.2
34
54
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
10.6
13.2
25
24
K84
ICPC
Heart disease other
8.9
13.0
27
31
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.1
12.8
155
805
FEB10
NOMESCO Finland
Decompression and drainage of pericardium
70.2
12.5
14
*
Q20.00
ICD-10 Finland
Common arterial trunk
+∞
12.5
12
*
FAE00
NOMESCO Finland
Anastomosis to pulmonary artery from superior vena cava
+∞
12.5
12
*
FAE10
NOMESCO Finland
Bidirectional anastomosis between superior vena cava and pulmonary artery
+∞
12.5
12
*
FXA13
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia and exclusive cerebral perfusion
+∞
12.5
12
*
FBA96
NOMESCO Finland
Other suture or repair of pulmonary artery
+∞
12.5
12
*
Q25.4
ICD-10 Finland
Other congenital malformations of aorta
+∞
12.5
12
*
FLE96
NOMESCO Finland
Other repair of outlet obstruction of left ventricle
+∞
12.5
12
*
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
4.5
12.4
44
102
GAA10
NOMESCO Finland
Intercostal insertion of pleural drainage tube
8.5
12.2
26
31
602
Kela drug reimbursment
Children's severe malnutrition
4.0
12.1
48
124
C09AA05
ATC
ramipril; oral
2.6
12.1
91
372
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.1
12.0
148
770
JDB10
NOMESCO Finland
Percutaneous gastrostomy
7.6
11.9
27
36
207
Kela drug reimbursment
Chronic arrhythmias
3.2
11.7
61
197
I44.2
ICD-10 Finland
Atrioventricular block, complete
9.7
11.7
23
24
7AX01
NOMESCO Finland
NA
19.0
11.5
17
9
RK260
NOMESCO Finland
NA
23.0
11.5
16
7
I28.8
ICD-10 Finland
Other specified diseases of pulmonary vessels
+∞
11.4
11
*
Q21.9
ICD-10 Finland
Congenital malformation of cardiac septum, unspecified
+∞
11.4
11
*
Q25.45
ICD-10 Finland
Congenital aortic aneurysm
+∞
11.4
11
*
AJ1
HP
Reconstruction of the aortic base, eg composite graft, incl. valve saving operation
120.2
11.4
12
*
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.9
11.3
192
1135
J01CA04
ATC
amoxicillin; systemic
2.1
11.1
625
5425
FCA50
NOMESCO Finland
Resection and reconstruction of ascending aorta using tube graft
43.4
10.9
13
*
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
3.6
10.8
48
137
R50.9
ICD-10 Finland
Fever, unspecified
2.0
10.6
161
907
B01AB05
ATC
enoxaparin; parenteral
2.1
10.6
130
673
C09AA02
ATC
enalapril; systemic
2.5
10.5
85
361
FJD20
NOMESCO Finland
Bypass of pulmonary valve with ventriculopulmonary prosthesis or homograft
+∞
10.4
10
*
21
HP
Aortic Valve Replacement (AVR)
+∞
10.4
10
*
FPF20
NOMESCO Finland
Implantation of epicardial pacemaker with atrial and ventricular electrodes
+∞
10.4
10
*
FBE96
NOMESCO Finland
Other expansion or reconstruction of pulmonary artery
+∞
10.4
10
*
5255
FHL
Deep hypothermia (<20 °) with cardiopulmonary resuscitation
+∞
10.4
10
*
FPH00
NOMESCO Finland
Transvenous extraction of transvenous cardiac pacemaker or cardioverter-defibrillator
110.0
10.4
11
*
FCC45
NOMESCO Finland
Percutaneous insertion of stent into descending aorta
110.0
10.4
11
*
AP3
HP
Catheterization of the right and left side of the heart
32.6
10.3
13
*
TFC10
NOMESCO Finland
Catheterisation of left atrium or ventricle
18.8
10.2
15
8
FN1CD
NOMESCO Finland
Very extensive CT of coronary arteries
18.8
10.2
15
8
ZX120
NOMESCO Finland
Intravenous
2.5
10.1
83
356
C07AA07
ATC
sotalol; systemic
6.3
10.1
26
42
FM1CD
NOMESCO Finland
Very extensive CT of heart
40.1
9.9
12
*
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
9.9
154
877
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
9.6
9.7
19
20
R62.0
ICD-10 Finland
Delayed milestone
3.0
9.7
57
201
81
HP
Angiography of the heart and coronary arteries
4.9
9.6
30
62
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
9.1
9.5
19
21
FP1B5
NOMESCO Finland
Resting ECG, 12 leads
6.7
9.4
23
35
FCA75
NOMESCO Finland
Valve-sparing repair of aortic root (David, Yacoub)
99.9
9.4
10
*
Q20.40
ICD-10 Finland
Double inlet left ventricle
+∞
9.3
9
*
Q21.31
ICD-10 Finland
Tetralogy of Fallot and double outlet right ventricle
+∞
9.3
9
*
Q24.3
ICD-10 Finland
Pulmonary infundibular stenosis
+∞
9.3
9
*
FMA20
NOMESCO Finland
Plastic repair of aortic valve for stenosis
+∞
9.3
9
*
Q24.0
ICD-10 Finland
Dextrocardia
+∞
9.3
9
*
FMD40
NOMESCO Finland
Replacement of aortic root using pulmonary autograft and reimplantation of coronary arteries (Ross)
+∞
9.3
9
*
7463A
ICD-9 Finland
Other congenital anomalies of heart, Congenital stenosis of aortic valve[STENOSIS VALVULAE AORTAE CONGENITA]
+∞
9.3
9
*
FHE30
NOMESCO Finland
Repair of tetralogy of Fallot with transannular patch
+∞
9.3
9
*
Q24.9
ICD-10 Finland
Congenital malformation of heart, unspecified
+∞
9.3
9
*
5609
FHL
Other measure in this category
+∞
9.3
9
*
Z2446
NOMESCO Finland
Social worker
2.0
9.3
123
655
WZC30
NOMESCO Finland
Teaching
2.3
9.2
87
401
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
6.3
9.0
23
37
TJD20
NOMESCO Finland
Change of gastrostomy tube
5.9
9.0
24
41
F83
ICD-10 Finland
Mixed specific developmental disorders
3.1
9.0
48
159
FM1BD
NOMESCO Finland
Extensive CT of heart
36.7
9.0
11
*
I25.1
ICD-10 Finland
Atherosclerotic heart disease
2.4
8.9
73
313
I47.2
ICD-10 Finland
Ventricular tachycardia
8.6
8.7
18
21
ZX199
NOMESCO Finland
Other rote
6.6
8.6
21
32
AN1
HP
Coronary angiography
3.1
8.6
46
153
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
4.4
8.6
30
70
3A019
NOMESCO Finland
NA
11.6
8.5
15
13
PD5CD
NOMESCO Finland
Very extensive CT angiography of aorta
27.5
8.4
11
*
90492
NOMESCO Finland
NA
89.8
8.4
9
*
PD5CM
NOMESCO Finland
Extensive MRI examination of thoracal and abdominal aorta with 3 Tesla magnet
+∞
8.3
8
*
FCC50
NOMESCO Finland
Resection and reconstruction of descending aorta using tube graft
+∞
8.3
8
*
GAB00
NOMESCO Finland
Emergency thoracotomy
+∞
8.3
8
*
Q22.5
ICD-10 Finland
Ebstein anomaly
+∞
8.3
8
*
74699
ICD-8 Finland
Congenital anomalies of heart, Unspecified anomalies of heart
+∞
8.3
8
*
Q25.43
ICD-10 Finland
(Ruptured) aneurysm of sinus Valsalva
+∞
8.3
8
*
5207
FHL
VSD closure
+∞
8.3
8
*
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.1
8.3
44
146
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.9
8.1
122
682
Z3226
NOMESCO Finland
Physiotherapist
1.7
8.1
177
1122
UGC12
NOMESCO Finland
Flexible bronchoscopy
2.9
8.0
47
166
Q90.0
ICD-10 Finland
Trisomy 21, meiotic nondisjunction
33.3
8.0
10
*
WX870
NOMESCO Finland
Other postsurgical intensive care
11.7
8.0
14
12
I10
ICD-10 Finland
Essential (primary) hypertension
1.7
8.0
189
1226
324
NOMESCO Finland
NA
22.0
8.0
11
5
3A077
NOMESCO Finland
NA
22.0
8.0
11
5
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
3.0
7.9
45
156
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
4.7
7.8
25
54
XX9BW
NOMESCO Finland
Submitting image material and/or investigation material to authority or other institution
7.0
7.7
18
26
AB1
HP
AVR mechanical
44.8
7.7
9
*
FC1BC
NOMESCO Finland
Extensive angiography of thoracal aortta
44.8
7.7
9
*
ZXX09
NOMESCO Finland
Extent of procedure, more than 8 units
44.8
7.7
9
*
1CX08
NOMESCO Finland
NA
15.0
7.7
12
8
Z31.5
ICD-10 Finland
Genetic counselling
2.4
7.7
67
296
FPE20
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with atrial and ventricular electrodes
5.0
7.5
23
47
Z3229
NOMESCO Finland
Other healthcare associate professional
2.1
7.5
87
439
AA5HE
NOMESCO Finland
Brain ultrasound examination in a child
2.8
7.5
47
172
ZF61V
NOMESCO Finland
NA
79.8
7.4
8
*
5253
FHL
Cardiac lung machine
79.8
7.4
8
*
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
2.1
7.3
81
400
74659
ICD-8 Finland
Congenital anomalies of heart, Maleformatio valvulae mitralis
+∞
7.3
7
*
I37.2
ICD-10 Finland
Pulmonary valve stenosis with insufficiency
+∞
7.3
7
*
74673
ICD-8 Finland
Congenital anomalies of heart, Stenosis valvulae aortae
+∞
7.3
7
*
FDE96
NOMESCO Finland
Other closure of patent ductus arteriosus
+∞
7.3
7
*
FBE00
NOMESCO Finland
Expansion of pulmonary artery
+∞
7.3
7
*
FDJ30
NOMESCO Finland
Reconstruction of aorta for coarctation using tube graft
+∞
7.3
7
*
5512
FHL
Cleavage or ligation of the ductus arteriosus
+∞
7.3
7
*
74619
ICD-8 Finland
Congenital anomalies of heart, Transposition of great vessels
+∞
7.3
7
*
Q20.8
ICD-10 Finland
Other congenital malformations of cardiac chambers and connections
+∞
7.3
7
*
Q25.5
ICD-10 Finland
Atresia of pulmonary artery
+∞
7.3
7
*
Q23.20
ICD-10 Finland
Congenital mitral stenosis
+∞
7.3
7
*
FAE30
NOMESCO Finland
Total cavo-pulmonary connection using fenestrated patch
+∞
7.3
7
*
I36.1
ICD-10 Finland
Nonrheumatic tricuspid (valve) insufficiency
10.9
7.2
13
12
F79.0
ICD-10 Finland
Unspecified mental retardation, with the statement of no, or minimal, impairment of behaviour
4.2
7.2
26
63
H66.0
ICD-10 Finland
Acute suppurative otitis media
1.7
7.2
172
1113
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
2.8
7.2
44
161
TFP00
NOMESCO Finland
Temporary use of transvenous or epicardial pacemaker
15.7
7.2
11
7
J21.9
ICD-10 Finland
Acute bronchiolitis, unspecified
2.9
7.1
42
150
I97.0
ICD-10 Finland
Postcardiotomy syndrome
29.9
7.1
9
*
R06.0
ICD-10 Finland
Dyspnoea
1.8
7.1
122
715
XG460
NOMESCO Finland
Short time oxymetry
6.0
7.0
18
30
Q87.88
ICD-10 Finland
Other specified congenital malformation syndromes, not elsewhere classified
8.8
7.0
14
16
C07AB03
ATC
atenolol; systemic
4.0
6.9
26
66
B34.9
ICD-10 Finland
Viral infection, unspecified
2.4
6.9
55
234
C08CA02
ATC
felodipine; oral
3.2
6.9
34
108
J45.1
ICD-10 Finland
Nonallergic asthma
2.1
6.9
78
390
I27.0
ICD-10 Finland
Primary pulmonary hypertension
39.9
6.7
8
*
J21.0
ICD-10 Finland
Acute bronchiolitis due to respiratory syncytial virus
3.0
6.6
35
117
Q90.9
ICD-10 Finland
Down syndrome, unspecified
22.4
6.6
9
*
I35.9
ICD-10 Finland
Aortic valve disorder, unspecified
22.4
6.6
9
*
RS221
NOMESCO Finland
NA
3.5
6.6
29
85
R07.4
ICD-10 Finland
Chest pain, unspecified
1.8
6.5
119
707
I33.0
ICD-10 Finland
Acute and subacute infective endocarditis
12.2
6.5
11
9
Q87.06
ICD-10 Finland
Velocardiofacial syndrome
69.5
6.4
7
*
TFC20
NOMESCO Finland
Catheterisation of both sides of heart
69.5
6.4
7
*
AJ2
HP
Reconstruction of the ascending aorta
69.5
6.4
7
*
Q90
ICD-10 Finland
Down syndrome
69.5
6.4
7
*
I49.3
ICD-10 Finland
Ventricular premature depolarization
3.1
6.4
33
109
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.2
6.4
66
317
TFJ02
NOMESCO Finland
Muscle biopsy of heart
11.0
6.3
11
10
FDH10
NOMESCO Finland
Reconstruction of interrupted or hypoplastic aortic arch using patch
+∞
6.2
6
*
FLE00
NOMESCO Finland
Excision of subvalvular membrane of left ventricle
+∞
6.2
6
*
Q21.18
ICD-10 Finland
Other spedified atrial septal defect
+∞
6.2
6
*
FAE96
NOMESCO Finland
Other connection to pulmonary artery from superior vena cava
+∞
6.2
6
*
AF1
HP
Surgery of congenital heart defect
+∞
6.2
6
*
Q21.20
ICD-10 Finland
Atrial septal defect of primum type
+∞
6.2
6
*
FBJ00
NOMESCO Finland
Anastomosis to pulmonary artery from subclavian artery
+∞
6.2
6
*
Q26.3
ICD-10 Finland
Partial anomalous pulmonary venous connection
+∞
6.2
6
*
7455A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Ostium secundum type atrial septal defect
+∞
6.2
6
*
FDA96
NOMESCO Finland
Other operation for HLHS
+∞
6.2
6
*
7451B
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Transposition of great vessels[DOUBLE OUTLET RIGHT VENTRICLE]
+∞
6.2
6
*
74729
ICD-8 Finland
Other congenital anomalies of circulatory system, Maleformationes aortae aliae
+∞
6.2
6
*
FLE10
NOMESCO Finland
Myotomy or myectomy of left ventricle for outlet obstruction
+∞
6.2
6
*
Q24.8
ICD-10 Finland
Other specified congenital malformations of heart
+∞
6.2
6
*
7454A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Ventricular septal defect[DEFECTUS SEPTI VENTRICULORUM NUD]
+∞
6.2
6
*
FMC20
NOMESCO Finland
Suture of leaflet of aortic valve
+∞
6.2
6
*
Q23.9
ICD-10 Finland
Congenital malformation of aortic and mitral valves, unspecified
+∞
6.2
6
*
PD5DM
NOMESCO Finland
Very extensive MRI examination of thoracal and abdominal aorta with 3 Tesla magnet
+∞
6.2
6
*
Z95.8
ICD-10 Finland
Presence of other cardiac and vascular implants and grafts
26.5
6.2
8
*
PD5AD
NOMESCO Finland
CT of aorta
7.0
6.2
14
20
WX002
NOMESCO Finland
Sedation and analgesia
1.8
6.1
101
582
I47.1
ICD-10 Finland
Supraventricular tachycardia
2.9
6.1
35
123
Z94.1
ICD-10 Finland
Heart transplant status
8.6
6.0
12
14
Mortality – FinRegistry
↥Association
Association between endpoint Q17_CONGEN_MALFO_GREAT_ARTERIES and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CONGEN_MALFO_GREAT_ARTERIES | 3.101 [2.4, 4.0] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.421 |
During the follow-up period (1.1.1998 — 31.12.2019), 246 out of 5292 females with Q17_CONGEN_MALFO_GREAT_ARTERIES died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CONGEN_MALFO_GREAT_ARTERIES | 2.705 [2.21, 3.31] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 278 out of 5278 males with Q17_CONGEN_MALFO_GREAT_ARTERIES died.
Mortality risk
Mortality risk for people of age
years, who have Q17_CONGEN_MALFO_GREAT_ARTERIES.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.375% | 0.496% |
| 5 | 1.882% | 2.813% |
| 10 | 4.585% | 7.174% |
| 15 | 8.942% | 13.541% |
| 20 | 15.7% | 22.229% |
Relationships between endpoints
↥Index endpoint: Q17_CONGEN_MALFO_GREAT_ARTERIES – Congenital malformations of great arteries
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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