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Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx, including Hilmo

Endpoint Browser

C3_LIP_ORAL_PHARYNX_NAS_WIDE

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — C14
  • Hospital discharge: ICD-9 — 149
  • Hospital discharge: ICD-8 — 149
  • Cause of death: ICD-10 — C14
  • Cause of death: ICD-9 — 149
  • Cause of death: ICD-8 — 149
  • Cancer registry: Topography ICD-O-3 — C14
  • Cancer registry: Morphology ICD-O-3 — ANY
  • Cancer registry: Behaviour codes — 3

3 out of 7 registries used, show all original rules.

93

4. Check minimum number of events

None

93

5. Include endpoints

None

93

6. Filter based on genotype QC (FinnGen only)

89

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

First used in FinnGen datafreeze
DF12

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 89 20 69
Unadjusted period prevalence (%) 0.03 0.01 0.03
Median age at first event (years) 67.35 65.36 67.93

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
93
Matched controls
930
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
130
Kela drug reimbursment
Malignant tumour
+∞
41.9
37
*
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
480.9
34.3
32
*
A03FA01
ATC
metoclopramide; systemic, rectal
14.6
33.7
38
42
JDB10
NOMESCO Finland
Percutaneous gastrostomy
435.8
31.9
30
*
UDQ12
NOMESCO Finland
Flexible laryngoscopy
14.3
28.0
30
30
WZC00
NOMESCO Finland
Treatment plan or consultation
9.7
27.9
55
121
C14.0
ICD-10 Finland
Malignant neoplasm: Pharynx, unspecified
+∞
27.4
25
*
UJC01
NOMESCO Finland
Scopy of lower throat
131.4
27.4
28
*
WF002
NOMESCO Finland
Radical radiotherapy
355.5
27.2
26
*
C14.1
ICD-10 Finland
Malignant neoplasm of laryngopharynx unspecified
+∞
25.1
23
*
R13
ICD-10 Finland
Dysphagia
11.9
22.7
27
31
N02AA05
ATC
oxycodone; systemic
7.8
19.6
36
70
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
19.4
18
*
H02AB02
ATC
dexamethasone; systemic
66.8
18.9
21
*
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
117.9
18.3
19
*
GBB00
NOMESCO Finland
Tracheostomy
62.8
17.8
20
*
8070/3-C14.0
ICD-O-3
Squamous cell carcinoma, NOS, of pharynx, NOS
+∞
17.2
16
*
UDQ22
NOMESCO Finland
Microlaryngoscopy
102.9
16.2
17
*
A04AA02
ATC
granisetron; systemic, transdermal
+∞
16.1
15
*
XX3DW
NOMESCO Finland
Time consuming IT work
17.5
15.9
25
19
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
15.0
14
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
20.4
14.3
21
13
DQB10
NOMESCO Finland
Endoscopic excision of lesion of larynx
+∞
13.9
13
*
ENA10
NOMESCO Finland
Biopsy of pharynx
+∞
13.9
13
*
C14.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of lip, oral cavity and pharynx
+∞
13.9
13
*
C32.0
ICD-10 Finland
Malignant neoplasm: Glottis
+∞
12.8
12
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
12.8
12
*
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
31.8
12.5
16
6
R4190
NOMESCO Finland
Nutritional therapy
54.3
12.3
14
*
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
136.2
11.7
12
*
D14.1
ICD-10 Finland
Benign neoplasm: Larynx
136.2
11.7
12
*
A04AA01
ATC
ondansetron; systemic, rectal
40.6
11.6
14
*
Z51.5
ICD-10 Finland
Palliative care
18.6
11.3
17
11
WX408
NOMESCO Finland
General anesthesy, balanced
4.7
11.3
36
110
EBA15
NOMESCO Finland
Extraction of multiple teeth
15.6
11.2
18
14
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
123.3
10.7
11
*
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
4.2
10.6
51
210
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
+∞
10.6
10
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
10.6
10
*
DQA10
NOMESCO Finland
Biopsy of larynx
+∞
10.6
10
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
10.1
10.6
21
26
EJA10
NOMESCO Finland
Biopsy of tongue or floor of mouth
61.6
9.9
11
*
EBA10
NOMESCO Finland
Operative extraction of tooth
5.8
9.6
20
42
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
+∞
9.5
9
*
C13.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of hypopharynx
+∞
9.5
9
*
DQB30
NOMESCO Finland
Laryngectomy
+∞
9.5
9
*
8070/3-C32.9
ICD-O-3
Squamous cell carcinoma, NOS, of larynx, NOS
+∞
9.5
9
*
C77.0
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Lymph nodes of head, face and neck
+∞
9.5
9
*
ZX095
NOMESCO Finland
Combined chemoradiotherapy
+∞
9.5
9
*
SAA03
NOMESCO Finland
Extended examination of mouth
3.9
9.5
44
174
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
4.9
8.8
23
59
JN4AD
NOMESCO Finland
Body CT examination
12.5
8.7
15
14
D38.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Larynx
+∞
8.5
8
*
C32.9
ICD-10 Finland
Malignant neoplasm: Larynx, unspecified
+∞
8.5
8
*
TJD20
NOMESCO Finland
Change of gastrostomy tube
+∞
8.5
8
*
PJD81
NOMESCO Finland
Excision of lymph nodes from upper part of neck
+∞
8.5
8
*
UJC12
NOMESCO Finland
Flexible oesophagoscopy
+∞
8.5
8
*
C13.9
ICD-10 Finland
Malignant neoplasm: Hypopharynx, unspecified
+∞
8.5
8
*
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
12.4
7.6
13
12
ZX090
NOMESCO Finland
Other technic of radiotherapy
86.7
7.5
8
*
C32.1
ICD-10 Finland
Malignant neoplasm: Supraglottis
+∞
7.4
7
*
DQE00
NOMESCO Finland
Implantation of prosthetic replacement for larynx
+∞
7.4
7
*
L03AA02
ATC
filgrastim; parenteral
+∞
7.4
7
*
PJD71
NOMESCO Finland
Extended sparing excision of cervical lymph nodes
+∞
7.4
7
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
7.4
7
*
YA1VG
NOMESCO Finland
MRI examination of head and neck with high intesity magnet for dose design of radiotherapy
+∞
7.4
7
*
ZX070
NOMESCO Finland
Intensity modified radiotherapy
+∞
7.4
7
*
K05.31
ICD-10 Finland
Periodontitis pronounced
4.7
7.3
19
48
UDQ02
NOMESCO Finland
Direct laryngoscopy
22.1
7.3
10
5
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
32.8
7.3
9
*
WX402
NOMESCO Finland
General anaesthesia
4.1
7.1
23
69
UDH02
NOMESCO Finland
Rhinopharyngoscopy
6.9
7.0
17
29
R22.1
ICD-10 Finland
Localized swelling, mass and lump, neck
15.8
6.6
10
7
H03AA01
ATC
levothyroxine sodium; systemic
3.5
6.5
28
102
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
74.8
6.5
7
*
SXA10
NOMESCO Finland
Oral mucosal sampling
74.8
6.5
7
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.2
6.5
35
147
TGB20
NOMESCO Finland
Tracheostomy tube replacement
+∞
6.3
6
*
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
+∞
6.3
6
*
OAB73
NOMESCO Finland
Prevention and treatment of malnutrition
+∞
6.3
6
*
JCA55
NOMESCO Finland
Endoscopic dilatation of oesophagus
+∞
6.3
6
*
C09.0
ICD-10 Finland
Malignant neoplasm: Tonsillar fossa
+∞
6.3
6
*
116
Kela drug reimbursment
Prostate cancer
+∞
6.3
6
*
JDB00
NOMESCO Finland
Gastrostomy
+∞
6.3
6
*
D10.9
ICD-10 Finland
Benign neoplasm: Pharynx, unspecified
+∞
6.3
6
*
Z51.0
ICD-10 Finland
Radiotherapy session
+∞
6.3
6
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
+∞
6.3
6
*
C32.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of larynx
+∞
6.3
6
*
8070/3-C13.9
ICD-O-3
Squamous cell carcinoma, NOS, of hypopharynx, NOS
+∞
6.3
6
*
JN4KR
NOMESCO Finland
Whole body very extensive metabolic PET with CT
+∞
6.3
6
*
A04AD12
ATC
aprepitant; systemic
+∞
6.3
6
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.5
6.3
26
92
R07.0
ICD-10 Finland
Pain in throat
11.1
6.2
11
11
A07AA02
ATC
nystatin; oral
6.7
6.1
15
26
SCA01
NOMESCO Finland
Preventive oral health care, short
3.3
6.0
29
113

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
26
17
20.69
17.49
1.6
1.4
—
—
—
0
0
25
37
8.87
17.09
2.8
1.5
0.21
0.22
g/l
0.30
25
29
34
94
5.13
12.18
7.2
2.4
0.77
0.84
mmol/l
4.21
34
86
49
183
4.55
11.96
3.6
1.5
—
—
—
0
0
42
157
4.05
9.90
4.1
3.8
—
—
—
0
0
64
335
3.92
8.90
12.9
5.6
4.36
4.11
e9/l
0.44
57
287
26
79
4.18
7.97
2.5
1.9
—
—
—
0
0
42
179
3.46
7.81
4.0
2.1
—
—
—
0
0
18
43
4.95
7.40
1.8
1.0
—
—
—
0
0
55
285
3.28
7.29
9.7
4.9
1.21
1.21
mmol/l
0.00
50
245
58
318
3.19
6.84
14.9
15.8
1.29
1.34
inr
0.14
16
89
51
281
2.80
5.63
5.8
5.4
—
—
—
0
0
21
71
3.53
5.40
8.5
6.1
1.51
1.95
mmol/l
0.21
14
59
51
303
2.51
4.55
6.4
5.4
1.63
1.79
e9/l
0.67
45
268
50
298
2.47
4.39
5.7
5.2
0.65
0.59
e9/l
0.69
42
259
50
298
2.47
4.39
6.4
5.2
0.04
0.04
e9/l
0.33
42
262
51
308
2.45
4.33
5.8
5.2
0.16
0.20
e9/l
0.92
44
270
47
281
2.36
3.99
6.0
5.2
65.13
57.43
%
3.49
42
258
22
92
2.82
3.93
2.0
1.8
—
—
—
0
0
32
165
2.43
3.75
6.5
3.1
7.39
7.39
ph
—
7
23
19
77
2.84
3.57
7.8
5.7
102.95
103.22
mmol/l
0.07
19
77
11
28
4.31
3.42
10.0
6.7
—
—
—
0
0
29
150
2.36
3.33
1.5
1.2
—
—
—
0
0
23
107
2.53
3.31
2.5
2.3
2.47
2.43
mmol/l
0.47
17
84
6
7
9.05
3.31
1.0
1.1
—
—
—
0
0
14
51
3.05
3.15
6.5
3.5
—
—
—
0
0
10
26
4.18
3.08
9.3
7.9
24.65
25.02
mmol/l
—
10
26
55
391
2.00
2.66
4.2
3.7
—
43.20
—
0
5
25
134
2.18
2.59
10.5
5.0
—
—
—
0
0
16
70
2.55
2.58
1.3
1.5
—
—
—
0
0
12
46
2.85
2.47
10.0
7.7
—
—
—
0
0
10
37
2.90
2.14
9.9
8.4
95.85
91.83
%
—
10
37
10
37
2.90
2.14
9.9
8.2
0.54
0.77
%
—
10
37
10
38
2.82
2.08
9.5
8.2
1.69
1.82
%
—
10
38
10
38
2.82
2.08
3.8
3.3
1.26
1.21
mmol/l
—
10
32
23
132
1.99
1.97
2.0
1.9
8.54
4.19
e6/l
0.50
18
119
12
54
2.40
1.83
3.3
3.2
—
—
—
0
0
10
42
2.54
1.68
4.0
2.5
120.10
127.81
g/l
—
10
42
24
148
1.84
1.65
4.1
2.7
—
—
—
0
0
77
663
1.94
1.60
25.9
11.9
30.51
23.92
mg/l
1.20
67
498
27
176
1.75
1.55
2.6
2.5
1.14
0.25
e6/l
0.56
20
130
26
168
1.76
1.54
2.5
2.4
—
—
—
0
0
14
74
2.05
1.48
1.0
1.7
—
—
—
0
0
58
470
1.62
1.41
5.2
3.6
14.25
15.06
pmol/l
1.25
51
414
21
132
1.76
1.35
4.0
3.3
679.63
166.48
ng/l
0.56
16
113
20
124
1.78
1.35
1.7
2.4
432.53
570.55
mosm/kgh2o
2.18
15
102
8
34
2.48
1.33
1.4
1.5
10.68
9.41
g/l
—
8
29
5
18
2.87
1.30
2.2
1.7
—
—
—
0
0
60
496
1.59
1.30
5.0
3.9
—
—
—
0
0
27
188
1.61
1.20
2.6
2.6
109.69
367.25
e6/l
0.33
19
144
37
278
1.55
1.19
9.9
7.8
0.00
0.00
e9/l
-0.00
31
231
60
685
0.65
1.11
4.5
5.3
2.70
2.66
mmol/l
0.13
53
622
12
67
1.91
1.10
3.7
2.9
2.97
2.46
mmol/l
0.17
12
54
7
33
2.21
1.08
5.9
3.7
—
—
—
0
0
10
53
1.99
1.06
1.0
1.2
—
—
—
0
0
10
53
1.99
1.06
1.0
1.5
—
—
—
0
0
7
34
2.14
1.05
3.4
2.1
—
—
—
0
0
57
650
0.68
0.96
4.8
6.1
39.68
41.22
mmol/mol
0.76
49
597
29
217
1.49
0.93
2.8
3.1
230.08
59.78
e6/l
0.50
21
155
10
57
1.85
0.87
2.9
2.3
—
—
—
0
0
6
31
2.00
0.86
1.2
1.2
—
—
—
0
0
59
663
0.70
0.84
3.8
4.7
1.47
1.40
mmol/l
0.60
51
603
60
670
0.71
0.80
4.2
4.8
4.67
4.52
mmol/l
0.45
53
610
5
25
2.05
0.74
1.8
1.5
—
—
—
0
0
5
25
2.05
0.74
3.8
4.0
4.06
4.00
mmol/l
—
5
25
18
243
0.68
0.72
3.9
4.0
16.81
9.23
mg/mmol
0.32
11
149
5
26
1.97
0.72
4.2
4.0
4.32
1.12
mmol/l
—
5
26
13
86
1.59
0.70
1.2
1.2
—
—
—
0
0
7
43
1.68
0.68
2.7
2.4
—
—
—
0
0
19
140
1.45
0.65
3.4
3.4
—
—
—
0
0
5
29
1.76
0.65
1.0
1.4
—
—
—
0
0
77
714
1.46
0.63
31.4
14.4
82.40
84.52
umol/l
0.13
77
714
0
22
0.00
0.60
0.0
1.5
—
—
—
0
0
6
37
1.66
0.57
6.0
2.2
0.63
0.54
%
—
6
37
6
37
1.66
0.57
6.0
2.2
2.07
1.12
%
—
6
37
75
701
1.36
0.50
22.2
11.6
—
—
—
0
0
7
49
1.46
0.47
1.0
1.2
—
—
—
0
0
7
49
1.46
0.47
8.3
2.6
4.47
3.91
e9/l
—
7
36
18
226
0.75
0.46
2.5
3.3
—
—
—
0
0
48
430
1.24
0.42
5.4
3.5
—
—
—
0
0
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
65
603
1.26
0.41
6.5
4.3
3.44
1.96
mu/l
2.92
58
532
78
741
1.33
0.39
36.8
17.4
37.65
41.17
%
3.89
69
683
18
220
0.77
0.38
3.2
2.6
0.74
0.74
ug/l
0.00
13
136
60
643
0.81
0.37
3.4
4.3
1.30
1.33
mmol/l
0.11
52
582
19
229
0.79
0.36
2.7
3.4
60.29
339.65
mg/l
0.51
12
150
34
303
1.19
0.29
3.8
3.9
24.61
43.16
ng/l
1.46
29
219
60
564
1.18
0.27
28.0
13.1
14.41
15.05
%
0.64
60
552
63
659
0.86
0.21
4.1
4.6
5.84
6.14
mmol/l
1.48
56
590
0
11
0.00
0.21
0.0
2.2
—
—
—
0
0
0
11
0.00
0.21
0.0
3.6
—
—
—
0
0
0
11
0.00
0.21
0.0
2.2
—
104.82
—
0
11
0
11
0.00
0.21
0.0
2.2
—
4.19
—
0
11
6
47
1.30
0.21
2.8
1.9
—
—
—
0
0
7
60
1.18
0.18
1.3
1.2
—
—
—
0
0
7
60
1.18
0.18
3.7
3.4
473.00
157.85
ng/l
—
7
53
24
263
0.88
0.15
2.1
1.9
98.08
92.22
pmol/l
0.28
13
132
5
44
1.14
0.10
3.0
1.2
—
—
—
0
0
6
70
0.85
0.08
1.2
1.3
—
—
—
0
0
32
305
1.07
0.07
4.2
3.1
0.00
0.00
estimate
—
5
54
31
296
1.07
0.07
6.9
4.2
0.00
0.00
estimate
—
6
55
31
297
1.07
0.06
4.6
3.2
0.00
0.00
estimate
—
6
59
22
211
1.06
0.03
3.4
3.9
—
—
—
0
0
16
168
0.94
0.02
4.4
2.6
—
—
—
0
0
0
5
0.00
0.00
0.0
2.6
—
618.80
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
185.77
—
0
9
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
49
1.02
-0.00
4.8
2.9
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

↥

Index endpoint: C3_LIP_ORAL_PHARYNX_NAS_WIDE – Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx, including Hilmo

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).