Risteys · C3_MALE_GENITAL_NAS

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule only males	226837
2. Check conditions None	226837
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — C63 Hospital discharge: ICD-9 — 187 Hospital discharge: ICD-8 — 187 Cause of death: ICD-10 — C63 Cause of death: ICD-9 — 187 Cause of death: ICD-8 — 187 Cause of death: excluded ICD-9 — 187[1-4] Cause of death: excluded ICD-8 — 1870 Cancer registry: Topography ICD-O-3 — C63 Cancer registry: Morphology ICD-O-3 — ANY Cancer registry: Behaviour codes — 3 3 out of 7 registries used, show all original rules.	57
4. Check minimum number of events None	57
5. Include endpoints None	57
6. Filter based on genotype QC (FinnGen only)	57

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	57	-	57
Unadjusted period prevalence (%)	0.03	-	0.03
Median age at first event (years)	63.60	-	63.60

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3002256) Pathology report gross observation

8.90

10.28

1.1

1.0

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

6.30

8.27

4.0

2.0

u/l

216.8

249.2

0.86

(4035726)

9.89

7.83

1.8

1.2

—

(40768804) Tissue Pathology biopsy report

3.86

5.51

2.4

1.4

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

6.17

5.25

27.2

38.3

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

3.33

4.25

3.0

2.5

—

(3044640) Blood type and Crossmatch panel - Blood

114

3.13

4.14

3.1

2.3

—

(3000991) Gas panel - Venous blood

4.02

4.04

23.2

12.0

—

(3042936) Bacteria identified in Isolate by Culture

3.30

3.84

2.1

2.3

—

(3026008) Bacteria identified in Urine by Culture

3.11

3.82

3.9

2.8

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

3.36

3.81

3.6

2.4

e6/l

1.8

1.3

0.15

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

153

2.82

3.60

5.4

4.5

—

(3049717) Cytology report of Urine Cyto stain

5.63

3.18

1.5

1.8

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

6.47

3.12

1.4

4.3

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

189

2.58

3.04

12.1

3.8

umol/l

12.9

13.0

0.02

178

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

2.98

3.04

3.8

2.6

e6/l

1.5

1.1

—

(3003396) Base excess in Arterial blood by calculation

3.21

2.95

23.5

19.9

mmol/l

0.3

1.1

0.29

(3023368) Bacteria identified in Blood by Culture

125

2.59

2.94

8.7

3.9

—

(36304419) Bacteria [Presence] in Urine

2.67

2.87

5.0

2.3

—

(3030467) Casts [#/volume] in Urine by Automated count

104

2.61

2.83

5.0

2.5

e6/l

1.1

0.6

0.20

(3007853) Bacteria identified in Skin by Aerobe culture

2.87

2.61

1.7

1.9

—

(40758558) Short blood count panel - Blood

2.56

2.59

10.4

4.3

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

4.25

2.57

1.3

—

(42870588) Differential panel, method unspecified - Blood

133

2.39

2.51

9.8

4.6

—

(40768443) Skin Pathology biopsy report

5.44

2.47

1.0

1.1

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.59

2.29

2.5

1.6

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

5.96

2.26

1.4

1.3

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

228

2.22

2.19

14.6

5.4

e9/l

4.5

4.6

0.10

199

(3011397) Hemoglobin [Presence] in Urine by Test strip

2.42

2.19

2.9

3.3

—

(3002582) Erythrocytes [#/volume] in Urine

117

2.26

2.12

5.2

2.5

e6/l

238.8

136.8

0.17

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

5.36

2.11

1.6

1.1

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

2.66

2.04

3.5

3.2

20.9

25.5

0.96

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

137

2.14

1.95

5.0

2.8

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

3.15

1.95

1.4

1.7

—

(3027945) Reticulocytes/100 erythrocytes in Blood

2.66

1.91

2.5

1.5

1.7

1.5

0.65

(3004789) Transferrin [Mass/volume] in Serum or Plasma

2.55

1.89

3.2

3.0

g/l

2.2

2.3

0.27

(3018095) Leukocytes [#/volume] in Urine

131

2.11

1.85

5.9

3.0

e6/l

1629.5

22.8

0.50

(3032080) INR in Blood by Coagulation assay

184

2.03

1.80

6.8

11.9

inr

1.4

—

(3006315) Basophils [#/volume] in Blood

197

1.96

1.67

9.8

4.9

e9/l

0.0

0.19

174

(3001604) Monocytes [#/volume] in Blood

197

1.96

1.67

9.8

4.9

e9/l

0.6

0.09

171

(3052851) Hemolysis interference index of Serum or Plasma

3.81

1.65

20.0

3.6

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.92

1.64

1.0

1.5

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

3.23

1.63

2.8

2.5

—

(3019198) Lymphocytes [#/volume] in Blood

199

1.93

1.61

10.6

5.2

e9/l

2.8

1.8

0.50

178

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.48

1.57

2.6

1.7

—

(3000492) Spirometry study

2.55

1.51

1.1

1.4

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.37

1.43

2.4

1.6

—

(3013115) Eosinophils [#/volume] in Blood

205

1.84

1.42

10.8

5.1

e9/l

0.2

0.35

178

(3000494) Fungus identified in Specimen by Culture

2.35

1.41

1.4

2.0

—

(3037467) Urinalysis macro (dipstick) panel - Urine

263

1.86

1.41

4.9

3.4

—

(3012544) pH of Venous blood

2.21

1.25

6.0

4.1

—

(3022948) Iron [Moles/volume] in Serum or Plasma

2.07

1.25

3.7

2.8

umol/l

11.5

14.6

1.25

(3007930) Methemoglobin/Hemoglobin.total in Blood

2.78

1.24

6.4

27.8

0.9

—

(3021589) Normoblasts [#/volume] in Blood

168

1.74

1.16

17.0

8.3

e9/l

0.0

0.00

133

(3020630) Protein [Mass/volume] in Serum or Plasma

2.35

1.12

1.6

1.3

g/l

57.2

65.1

—

(3023081) Carboxyhemoglobin/Hemoglobin.total in Blood

2.51

1.11

6.4

25.6

1.9

1.4

—

(3002032) Base excess in Venous blood by calculation

2.04

1.07

5.0

3.7

mmol/l

-2.1

1.6

—

(1761868) Lipid panel - Serum or Plasma

130

0.47

1.04

2.7

3.5

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

309

1.69

1.02

12.8

5.1

u/l

80.1

72.9

0.77

285

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

2.07

1.01

1.6

1.4

—

(3003694) ABO and Rh group [Type] in Blood

1.81

0.99

1.1

1.2

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.01

0.98

1.6

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

2.36

0.97

3.3

3.6

g/l

127.5

127.7

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.36

0.97

1.3

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

262

1.62

0.94

13.5

6.2

mmol/l

6.8

7.0

0.17

246

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

1.71

0.85

6.9

3.5

ng/l

53.3

146.9

0.61

(3019060) Gas panel - Arterial blood

1.98

0.84

5.8

19.1

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.77

0.83

1.9

1.8

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

0.00

0.79

0.0

2.3

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

406

0.64

0.79

5.8

5.4

mmol/l

2.4

2.5

0.16

368

(3002385) Erythrocyte distribution width [Ratio]

320

1.56

0.78

41.4

15.1

14.2

13.7

1.22

311

(3012516) Albumin [Mass/volume] in Urine

152

0.59

0.75

3.7

3.2

mg/l

11.6

101.1

—

105

(3001122) Ferritin [Mass/volume] in Serum or Plasma

139

1.55

0.73

3.6

2.6

ug/l

175.6

191.4

0.08

126

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

1.86

0.68

9.6

3.9

mmol/l

19.0

23.9

—

(3019150) Specific gravity of Urine by Refractometry

0.55

0.62

5.0

3.4

—

1.0

—

(3017732) Neutrophils [#/volume] in Blood

0.00

0.60

0.0

4.1

—

3.4

—

(3022145) Colonoscopy Study observation

1.74

0.59

1.0

1.3

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.56

0.53

5.5

3.0

—

(3044889) 12 lead EKG panel

294

1.39

0.51

4.8

4.0

—

(3041096) Erythrocytes [Presence] in Urine by Automated

100

0.66

0.44

4.3

2.7

—

(3015736) pH of Urine

143

1.38

0.44

3.1

—

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

1.62

0.43

6.8

5.1

ng/l

87.6

109.3

—

(4034850)

0.00

0.42

0.0

11.3

—

(3020961) Endomysium IgA Ab [Titer] in Serum

0.00

0.41

0.0

1.2

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

396

0.75

0.39

4.7

4.9

mmol/l

5.9

6.2

1.19

349

(40761535) Cells panel - Urine sediment

1.43

0.39

6.4

3.5

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

374

1.34

0.38

26.5

12.3

ml/min/173m2

65.7

75.1

1.47

301

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

245

1.28

0.34

6.1

3.7

27.3

25.6

0.13

117

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

383

0.78

0.34

5.5

7.0

mmol/mol

39.3

41.6

1.08

350

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

1.39

0.33

4.0

3.0

ug/l

5.4

9.3

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

103

1.34

0.31

2.8

1.8

mg/l

3.0

2.7

0.25

(3009542) Hematocrit [Volume Fraction] of Blood

348

1.28

0.31

45.6

14.6

39.9

41.4

0.58

225

(40760892) CBC W Ordered Manual Differential panel - Blood

1.29

0.29

2.3

4.3

—

(3019309) Folate [Moles/volume] in Red Blood Cells

0.71

0.24

3.1

1.9

nmol/l

1116.7

1146.7

—

(3037522) Nuclear Ab [Titer] in Serum

1.27

0.23

1.2

1.4

—

283.3

—

(3019225) pH of Specimen

1.24

0.22

3.2

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

205

1.20

0.22

2.5

2.4

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.21

0.0

1.1

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.21

0.0

1.2

—

(3003327) Ova and parasites identified in Stool by Light microscopy

0.00

0.21

0.0

1.8

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.3

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.21

0.0

1.2

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

0.00

0.20

0.0

1.2

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.20

0.0

1.0

—

(3013512) EKG study

131

1.20

0.16

3.3

4.6

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

1.17

0.10

2.1

1.8

pmol/l

654545808.2

387.2

0.47

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

144

0.87

0.09

4.4

3.3

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

181

0.91

0.05

2.4

2.0

pmol/l

97.1

91.7

—

110

(40761511) CBC panel - Blood by Automated count

419

0.92

0.04

28.4

12.7

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

249

0.94

0.03

2.6

3.2

u/l

121.6

56.1

0.35

226

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

436

0.94

0.01

16.7

8.8

u/l

30.8

26.7

0.72

409

(3024731) MCV [Entitic volume]

447

1.03

0.00

46.6

19.2

91.6

91.3

0.19

436

(3035941) MCH [Entitic mass]

447

1.03

0.00

46.5

19.2

30.3

30.6

0.55

436

(3023103) Potassium [Moles/volume] in Serum or Plasma

427

1.03

0.00

43.6

17.8

mmol/l

4.0

0.50

412

(3000963) Hemoglobin [Mass/volume] in Blood

447

1.03

0.00

47.0

19.4

g/l

130.9

140.8

2.46

437

(3019550) Sodium [Moles/volume] in Serum or Plasma

426

1.04

0.00

42.6

17.8

mmol/l

139.8

139.6

0.09

412

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.2

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.3

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.0

1.9

—

4.2

—

(3008898) HLA-B27 [Presence]

0.00

0.0

1.0

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.0

1.2

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.0

1.9

—

105.1

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.0

1.9

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.00

0.0

1.3

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.4

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.0

3.1

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.0

1.0

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.0

1.6

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.0

1.0

—

(3009466) Valproate [Moles/volume] in Serum or Plasma

0.00

0.0

2.0

—

332.8

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.0

1.0

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.4

—

(4146454)

0.00

0.0

2.4

—

(3027008) Opiates [Presence] in Urine

0.00

0.0

1.2

—

(3000764) Benzodiazepines [Presence] in Urine

0.00

0.0

1.2

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

0.0

1.8

—

(3028300) Cannabinoids [Presence] in Urine

0.00

0.0

1.2

—

(3027944) Amphetamines [Presence] in Urine

0.00

0.0

1.2

—

(3016879) Cocaine [Presence] in Urine

0.00

0.0

1.2

—

(3011288) Drugs identified in Urine by Screen method

0.00

0.0

1.1

—

(40759040) C peptide [Moles/volume] in Serum or Plasma --post meal

0.00

0.0

1.2

—

1.5

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

0.00

0.0

1.1

—

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: C3_MALE_GENITAL_NAS_EXALLC – Malignant neoplasm of other and unspecified male genital organs, excluding all cancers (controls excluding all cancers)

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

NAME	C3_MALE_GENITAL_NAS_EXALLC
CONTROL_EXCLUDE	C3_CANCER\|C3_CANCER_WIDE_EXALLC
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX	1
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	C63
HD_ICD_9	187
HD_ICD_8	187
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	C63
COD_ICD_9	187
COD_ICD_8	187
COD_ICD_10_EXCL
COD_ICD_9_EXCL	187[1-4]
COD_ICD_8_EXCL	1870
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO	C63
CANC_TOPO_EXCL
CANC_MORPH	ANY
CANC_MORPH_EXCL
CANC_BEHAV	3

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Malignant neoplasm of other and unspecified male genital organs, excluding all cancers (controls excluding all cancers)

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Malignant neoplasm of other and unspecified male genital organs, excluding all cancers (controls excluding all cancers) (C3_MALE_GENITAL_NAS_EXALLC)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Relationships between endpoints