Non-seminoma of testis, excluding all cancers (controls excluding all cancers)

C3_TESTIS_NONSEMINOMA_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

only males

226837

2. Check conditions

None

226837

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C62.02&, C62.12&, C62.92&
  • Hospital discharge: ICD-9 186B
  • Cause of death: ICD-10 C62.02&, C62.12&, C62.92&
  • Cause of death: ICD-9 186B
  • Cancer registry: Topography ICD-O-3 C62
  • Cancer registry: Morphology ICD-O-3 907[01]|9080|9100
  • Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

225

4. Check minimum number of events

None

225

5. Include endpoints

None

225

6. Filter based on genotype QC (FinnGen only)

225

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12

Similar endpoints

List of similar endpoints to Non-seminoma of testis, excluding all cancers (controls excluding all cancers) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 225 - 225
Unadjusted period prevalence (%) 0.10 - 0.10
Median age at first event (years) 30.78 - 30.78

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
203
Matched controls
2029
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C62.12
ICD-10 Finland
Malignant tumor of the descending testicle, embryonic carsinoma, teratocarcinoma or coriocarsinoma
+∞
194.4
154
*
KFC00
NOMESCO Finland
Unilateral orchiectomy
1348.5
192.0
158
5
D40.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Testis
796.1
143.3
125
*
130
Kela drug reimbursment
Malignant tumour
+∞
114.8
99
*
A03FA01
ATC
metoclopramide; systemic, rectal
29.3
67.6
95
59
JN4BD
NOMESCO Finland
Extensive body CT
41.2
66.7
84
34
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
65.2
59
*
9085/3-C62.9
ICD-O-3
Mixed germ cell tumor of testis, NOS
+∞
57.0
52
*
9070/3-C62.9
ICD-O-3
Embryonal carcinoma, NOS, of testis, NOS
+∞
50.1
46
*
C62.10
ICD-10 Finland
Malignant tumor of the descending testicle, no histological verification
+∞
46.7
43
*
C62.19
ICD-10 Finland
Malignant tumor of the descending testicle, other or undetermined histology
+∞
45.6
42
*
L03AA02
ATC
filgrastim; parenteral
505.2
42.8
41
*
KF8AE
NOMESCO Finland
Ultrasound examination of scrotum
17.4
37.9
62
50
C62.92
ICD-10 Finland
Malignant tumor in unspecified location in testis, embryonic carsinoma, teratocarcinoma or coriocarsinoma
+∞
37.7
35
*
KFH50
NOMESCO Finland
Insertion of prosthetic replacement for testis
+∞
36.6
34
*
A04AA02
ATC
granisetron; systemic, transdermal
415.0
36.2
35
*
JN4AD
NOMESCO Finland
Body CT examination
61.8
35.0
40
8
H02AB02
ATC
dexamethasone; systemic
68.4
34.7
39
7
PJD53
NOMESCO Finland
Block dissection of aortic lymph nodes
+∞
32.1
30
*
C62.02
ICD-10 Finland
Malignant tumor of the non-descending testicle, embryonic carsinoma, teratocarcinoma or coriocarsinoma
+∞
31.0
29
*
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
+∞
31.0
29
*
C62.11
ICD-10 Finland
Malignant tumor of the descending testicle, seminoma
+∞
29.9
28
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.8
29.6
118
393
A04AA01
ATC
ondansetron; systemic, rectal
45.3
25.7
31
8
C62.99
ICD-10 Finland
Malignant tumor in unspecified location in testis,other or undetermined histology
+∞
25.6
24
*
C62.1
ICD-10 Finland
Malignant neoplasm: Descended testis
+∞
25.6
24
*
C62.90
ICD-10 Finland
Malignant tumor in unspecified location in testis, no histological verification
+∞
25.6
24
*
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
24.5
23
*
C77.2
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Intra-abdominal lymph nodes
+∞
23.4
22
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
7.1
20.8
55
101
9085/3-C62.1
ICD-O-3
Mixed germ cell tumor of descended testis
+∞
20.1
19
*
121
Kela drug reimbursment
Severe hypofunction of sexual glands
51.6
19.6
23
5
DFF00
NOMESCO Finland
Pure tone audiometry
9.7
18.3
38
47
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
+∞
18.0
17
*
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
+∞
16.9
16
*
9080/3-C62.9
ICD-O-3
Teratoma, malignant, NOS, of testis, NOS
+∞
16.9
16
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
16.9
16
*
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
16.6
15.8
25
17
C62.00
ICD-10 Finland
Malignant tumor of the non-descending testicle, no histological verification
+∞
15.8
15
*
9061/3-C62.9
ICD-O-3
Seminoma, NOS, of testis, NOS
+∞
15.8
15
*
WX408
NOMESCO Finland
General anesthesy, balanced
4.1
15.6
73
247
JN3AD
NOMESCO Finland
Abdominal CT examination
8.7
15.2
33
44
B01AB05
ATC
enoxaparin; parenteral
4.7
14.8
56
153
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
+∞
14.8
14
*
D70.82
ICD-10 Finland
Drug-induced neutropenia
161.1
14.7
15
*
N02BE01
ATC
paracetamol; systemic, rectal
3.9
13.8
171
1174
N45.9
ICD-10 Finland
Orchitis, epididymitis and epididymo-orchitis without abscess
9.7
13.8
28
33
7511
FHL
Orchidectomy (unilateral), also includes funicularectomy
149.6
13.6
14
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
3.4
13.1
81
333
18699
ICD-8 Finland
Malignant neoplasm of testis
+∞
12.6
12
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
12.6
12
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
12.9
12.1
21
18
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
5.9
11.9
34
67
C62.9
ICD-10 Finland
Malignant neoplasm: Testis, unspecified
+∞
11.6
11
*
9081/3-C62.9
ICD-O-3
Teratocarcinoma of testis, NOS
+∞
11.6
11
*
C62
ICD-10 Finland
Malignant neoplasm of testis
+∞
11.6
11
*
JN3BD
NOMESCO Finland
Extensive abdominal CT
6.0
11.2
31
59
B01AB10
ATC
tinzaparin; parenteral
11.5
11.1
20
19
ZXE00
NOMESCO Finland
One hour or less
2.9
10.7
82
381
E89.5
ICD-10 Finland
Postprocedural testicular hypofunction
+∞
10.5
10
*
WW500
NOMESCO Finland
Blood transfusion
20.1
10.4
15
8
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
8.0
10.3
23
32
WX402
NOMESCO Finland
General anaesthesia
3.9
10.1
44
135
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.1
9.9
40
114
N02AA05
ATC
oxycodone; systemic
5.5
9.6
28
57
L03AA13
ATC
pegfilgrastim; parenteral
+∞
9.4
9
*
9070/3-C62.1
ICD-O-3
Embryonal carcinoma, NOS, of descended testis
+∞
9.4
9
*
WZC30
NOMESCO Finland
Teaching
4.1
8.5
33
91
A04AD12
ATC
aprepitant; systemic
+∞
8.4
8
*
L03AA14
ATC
lipegfilgrastim; parenteral
+∞
8.4
8
*
C62.01
ICD-10 Finland
Malignant tumor of the non-descending testicle, seminoma
+∞
8.4
8
*
1869B
ICD-9 Finland
Malignant neoplasm of testis, Other and unspecified testis[NEOPL MAL TESTIS (SCROT),CA EMBR/TERATOCA/CHORIOCA]
+∞
8.4
8
*
KBV02
NOMESCO Finland
Cystoscopic insertion of stent into ureter
15.3
8.3
13
9
ZXE10
NOMESCO Finland
More than one and less than three hours
2.7
8.3
70
336
ZXD10
NOMESCO Finland
Scheduled procedure
2.6
8.2
70
339
Y05
ICPC
Scrotum/testis sympt/compl other
10.0
7.9
15
16
N05BA06
ATC
lorazepam; systemic, sublingual
6.6
7.8
19
31
ZX120
NOMESCO Finland
Intravenous
5.0
7.7
24
53
R50.9
ICD-10 Finland
Fever, unspecified
3.5
7.7
36
117
M04AA01
ATC
allopurinol; systemic
4.4
7.4
26
65
C61
ICD-10 Finland
Malignant neoplasm of prostate
+∞
7.3
7
*
C78.6
ICD-10 Finland
Secondary malignant neoplasm of retroperitoneum and peritoneum
+∞
7.3
7
*
Y78
ICPC
Malign neopl male genital other
+∞
7.3
7
*
9071/3-C62.9
ICD-O-3
Yolk sac tumor, NOS, of testis, NOS
+∞
7.3
7
*
XZZ00
NOMESCO Finland
Active surveillance of a diagnosed cancer
+∞
7.3
7
*
Z85.4
ICD-10 Finland
Personal history of malignant neoplasm of genital organs
+∞
7.3
7
*
Y83.9
ICD-10 Finland
Surgical procedure, unspecified as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
16.5
7.3
11
7
JN4CD
NOMESCO Finland
Very extensive body CT
20.9
7.2
10
5
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.4
7.1
25
63
WX320
NOMESCO Finland
Spinalanesthesy
3.0
6.9
40
152
N02AX02
ATC
tramadol; systemic, rectal
2.3
6.7
78
435
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
12.8
6.7
11
9
A02BC02
ATC
pantoprazole; systemic
2.1
6.5
107
697
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.2
6.4
33
116
WD135
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
6.3
6
*
C62.91
ICD-10 Finland
Malignant tumor in unspecified location in testis, seminoma
+∞
6.3
6
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
6.3
6
*
A04AA55
ATC
palonosetron, combinations; systemic
+∞
6.3
6
*
D29.2
ICD-10 Finland
Benign neoplasm: Testis
+∞
6.3
6
*
E29.1
ICD-10 Finland
Testicular hypofunction
7.1
6.2
14
21

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: C3_TESTIS_NONSEMINOMA_EXALLC – Non-seminoma of testis, excluding all cancers (controls excluding all cancers)

GWS hits: 2

This endpoint is excluded (different definition than used in FinnGen).