Malignant neoplasm of testis, excluding all cancers (controls excluding all cancers)

C3_TESTIS_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

only males

226837

2. Check conditions

None

226837

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C62
  • Hospital discharge: ICD-9 186
  • Hospital discharge: ICD-8 186
  • Cause of death: ICD-10 C62
  • Cause of death: ICD-9 186
  • Cause of death: ICD-8 186
  • Cancer registry: Topography ICD-O-3 C62
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

720

4. Check minimum number of events

None

720

5. Include endpoints

None

720

6. Filter based on genotype QC (FinnGen only)

720

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12

Similar endpoints

List of similar endpoints to Malignant neoplasm of testis, excluding all cancers (controls excluding all cancers) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 720 - 720
Unadjusted period prevalence (%) 0.32 - 0.32
Median age at first event (years) 37.17 - 37.17

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
566
Matched controls
5659
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
KFC00
NOMESCO Finland
Unilateral orchiectomy
1256.7
323.0
404
11
D40.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Testis
725.5
323.0
333
11
C62.11
ICD-10 Finland
Malignant tumor of the descending testicle, seminoma
+∞
268.8
236
*
9061/3-C62.9
ICD-O-3
Seminoma, NOS, of testis, NOS
+∞
245.1
217
*
130
Kela drug reimbursment
Malignant tumour
+∞
197.8
178
*
JN4BD
NOMESCO Finland
Extensive body CT
36.8
176.3
231
104
C62.12
ICD-10 Finland
Malignant tumor of the descending testicle, embryonic carsinoma, teratocarcinoma or coriocarsinoma
+∞
160.2
146
*
A03FA01
ATC
metoclopramide; systemic, rectal
17.6
130.1
220
197
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
1298.2
112.5
106
*
C62.10
ICD-10 Finland
Malignant tumor of the descending testicle, no histological verification
+∞
98.9
92
*
KF8AE
NOMESCO Finland
Ultrasound examination of scrotum
18.6
98.3
158
115
A04AA02
ATC
granisetron; systemic, transdermal
+∞
88.9
83
*
C62.19
ICD-10 Finland
Malignant tumor of the descending testicle, other or undetermined histology
+∞
88.9
83
*
JN4AD
NOMESCO Finland
Body CT examination
22.6
84.2
125
70
KFH50
NOMESCO Finland
Insertion of prosthetic replacement for testis
282.9
74.3
74
*
9085/3-C62.9
ICD-O-3
Mixed germ cell tumor of testis, NOS
+∞
73.5
69
*
C62.1
ICD-10 Finland
Malignant neoplasm: Descended testis
+∞
70.3
66
*
H02AB02
ATC
dexamethasone; systemic
58.8
69.4
81
16
L03AA02
ATC
filgrastim; parenteral
252.5
66.7
67
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.6
63.3
334
1344
9061/3-C62.1
ICD-O-3
Seminoma, NOS, of descended testis
+∞
62.7
59
*
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
+∞
60.5
57
*
7511
FHL
Orchidectomy (unilateral), also includes funicularectomy
629.5
58.8
57
*
C62.99
ICD-10 Finland
Malignant tumor in unspecified location in testis,other or undetermined histology
+∞
54.0
51
*
C62.90
ICD-10 Finland
Malignant tumor in unspecified location in testis, no histological verification
532.2
50.2
49
*
A04AA01
ATC
ondansetron; systemic, rectal
35.9
49.8
64
20
18699
ICD-8 Finland
Malignant neoplasm of testis
+∞
49.7
47
*
9070/3-C62.9
ICD-O-3
Embryonal carcinoma, NOS, of testis, NOS
+∞
48.6
46
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
4.1
47.8
242
866
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
+∞
39.0
37
*
JN3AD
NOMESCO Finland
Abdominal CT examination
7.5
38.4
96
150
JN3BD
NOMESCO Finland
Extensive abdominal CT
6.2
38.3
111
213
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
37.9
36
*
C62.91
ICD-10 Finland
Malignant tumor in unspecified location in testis, seminoma
+∞
37.9
36
*
121
Kela drug reimbursment
Severe hypofunction of sexual glands
30.3
37.5
50
18
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
36.9
35
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
104.5
36.2
39
*
C62.00
ICD-10 Finland
Malignant tumor of the non-descending testicle, no histological verification
+∞
35.8
34
*
C62.92
ICD-10 Finland
Malignant tumor in unspecified location in testis, embryonic carsinoma, teratocarcinoma or coriocarsinoma
+∞
35.8
34
*
L03AA13
ATC
pegfilgrastim; parenteral
+∞
35.8
34
*
C62.01
ICD-10 Finland
Malignant tumor of the non-descending testicle, seminoma
+∞
33.7
32
*
PJD53
NOMESCO Finland
Block dissection of aortic lymph nodes
+∞
33.7
32
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
33.7
32
*
9680/3-C62.9
ICD-O-3
Diffuse large B-cell lymphoma, NOS, of testis, NOS
+∞
32.6
31
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
341.7
32.2
32
*
XZZ00
NOMESCO Finland
Active surveillance of a diagnosed cancer
+∞
31.5
30
*
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
330.0
31.1
31
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
23.8
29.6
42
19
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
29.4
28
*
C62.02
ICD-10 Finland
Malignant tumor of the non-descending testicle, embryonic carsinoma, teratocarcinoma or coriocarsinoma
+∞
29.4
28
*
WX408
NOMESCO Finland
General anesthesy, balanced
3.3
29.4
181
704
D70.82
ICD-10 Finland
Drug-induced neutropenia
51.5
28.7
34
7
C77.2
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Intra-abdominal lymph nodes
+∞
28.4
27
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
28.4
27
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
27.3
26
*
9085/3-C62.1
ICD-O-3
Mixed germ cell tumor of descended testis
+∞
26.2
25
*
WF002
NOMESCO Finland
Radical radiotherapy
260.9
24.9
25
*
ZXE00
NOMESCO Finland
One hour or less
2.6
24.3
234
1189
C62.9
ICD-10 Finland
Malignant neoplasm: Testis, unspecified
+∞
24.1
23
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.0
24.1
106
309
9081/3-C62.9
ICD-O-3
Teratocarcinoma of testis, NOS
+∞
23.1
22
*
C62
ICD-10 Finland
Malignant neoplasm of testis
+∞
23.1
22
*
JN4CD
NOMESCO Finland
Very extensive body CT
20.4
21.0
31
16
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
+∞
21.0
20
*
1869A
ICD-9 Finland
Malignant neoplasm of testis, Other and unspecified testis[NEOPL MAL TESTIS (SCROTALIS),SEMINOMA]
+∞
21.0
20
*
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
3.9
20.5
91
266
N02BE01
ATC
paracetamol; systemic, rectal
2.6
20.3
459
3502
N02AA05
ATC
oxycodone; systemic
4.2
19.7
80
215
WD135
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
206.8
19.7
20
*
D29.2
ICD-10 Finland
Benign neoplasm: Testis
47.8
19.3
23
5
ZXE10
NOMESCO Finland
More than one and less than three hours
2.4
18.5
196
1011
WZC30
NOMESCO Finland
Teaching
3.8
18.1
80
232
N45.9
ICD-10 Finland
Orchitis, epididymitis and epididymo-orchitis without abscess
5.9
17.8
51
94
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
17.8
17
*
Y78
ICPC
Malign neopl male genital other
+∞
17.8
17
*
YL1BD
NOMESCO Finland
Extensive CT examination of pelvis for dose design of radiotherapy
+∞
17.8
17
*
XX3DW
NOMESCO Finland
Time consuming IT work
5.6
17.8
53
103
WX320
NOMESCO Finland
Spinalanesthesy
2.8
17.7
128
531
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.1
17.5
72
196
L01BC06
ATC
capecitabine; oral
+∞
16.7
16
*
9080/3-C62.9
ICD-O-3
Teratoma, malignant, NOS, of testis, NOS
+∞
16.7
16
*
WW500
NOMESCO Finland
Blood transfusion
12.1
16.7
30
26
WX402
NOMESCO Finland
General anaesthesia
3.1
16.3
100
371
DFF00
NOMESCO Finland
Pure tone audiometry
4.1
16.1
65
174
L03AA14
ATC
lipegfilgrastim; parenteral
+∞
15.7
15
*
1869B
ICD-9 Finland
Malignant neoplasm of testis, Other and unspecified testis[NEOPL MAL TESTIS (SCROT),CA EMBR/TERATOCA/CHORIOCA]
+∞
15.7
15
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
164.2
15.5
16
*
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
6.9
14.9
37
57
Y05
ICPC
Scrotum/testis sympt/compl other
10.1
14.9
29
30
ZXD10
NOMESCO Finland
Scheduled procedure
2.2
14.7
189
1050
E29.1
ICD-10 Finland
Testicular hypofunction
6.5
14.7
38
62
Z08.7
ICD-10 Finland
Follow-up examination after combined treatment for malignant neoplasm
+∞
14.6
14
*
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
+∞
14.6
14
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
7.2
14.1
34
50
ZX090
NOMESCO Finland
Other technic of radiotherapy
+∞
13.6
13
*
A04AD12
ATC
aprepitant; systemic
+∞
13.6
13
*
116
Kela drug reimbursment
Prostate cancer
+∞
13.6
13
*
C78.6
ICD-10 Finland
Secondary malignant neoplasm of retroperitoneum and peritoneum
+∞
13.6
13
*
ZX120
NOMESCO Finland
Intravenous
3.7
13.1
58
168
B01AB10
ATC
tinzaparin; parenteral
5.5
13.0
38
73
Z51.5
ICD-10 Finland
Palliative care
11.9
12.9
23
20
JN4JR
NOMESCO Finland
Whole body extensive metabolic PET with CT
51.2
12.9
15
*
B01AB05
ATC
enoxaparin; parenteral
2.3
12.8
133
661
WF004
NOMESCO Finland
Palliative radiotherapy
+∞
12.5
12
*
Z85.4
ICD-10 Finland
Personal history of malignant neoplasm of genital organs
+∞
12.5
12
*
C20.91
ICD-10 Finland
Malignant tumor of the rectum invasive carcinoma
+∞
12.5
12
*
E89.5
ICD-10 Finland
Postprocedural testicular hypofunction
132.7
12.5
13
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.2
12.1
46
117
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
47.7
11.9
14
*
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
66.3
11.6
13
*
A02BC02
ATC
pantoprazole; systemic
1.9
11.6
300
2136
1869X
ICD-9 Finland
Malignant neoplasm of testis, Other and unspecified testis[NEOPL MAL TESTIS (SCROTALIS),EI HIST VAHV]
+∞
11.5
11
*
5703
FHL
Removal of lymph nodes from the retroperitoneal space
+∞
11.5
11
*
ZX070
NOMESCO Finland
Intensity modified radiotherapy
+∞
11.5
11
*
C83.3
ICD-10 Finland
Diffuse large B-cell lymphoma
+∞
11.5
11
*
C85.9
ICD-10 Finland
Non-Hodgkin lymphoma, unspecified
+∞
11.5
11
*
YL1AD
NOMESCO Finland
CT examination of pelvis for dose design of radiotherapy
+∞
11.5
11
*
R50.9
ICD-10 Finland
Fever, unspecified
2.7
11.4
86
358
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.5
11.3
94
415
KF8AE
SPAT
NA
9.5
11.1
22
24
JN6BD
NOMESCO Finland
Extensive CT of torso and neck
44.2
11.0
13
*
KFA00
NOMESCO Finland
Exploration of testis
10.9
10.8
20
19
Z01.1
ICD-10 Finland
Examination of ears and hearing
2.6
10.5
79
331
C25.0
ICD-10 Finland
Malignant neoplasm: Head of pancreas
+∞
10.4
10
*
9591/3-C62.9
ICD-O-3
Malignant lymphoma, non-Hodgkin, NOS, of testis, NOS
+∞
10.4
10
*
C62.09
ICD-10 Finland
Malignant tumor of the non-descending testicle, other or undetermined histology
+∞
10.4
10
*
A04AA55
ATC
palonosetron, combinations; systemic
+∞
10.4
10
*
C62.0
ICD-10 Finland
Malignant neoplasm: Undescended testis
+∞
10.4
10
*
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
6.9
10.0
24
36
JA1AE
NOMESCO Finland
Ultrasound examination of groin and abdominal wall
9.0
9.8
20
23
N05BA06
ATC
lorazepam; systemic, sublingual
3.9
9.5
38
102
JN6AD
NOMESCO Finland
CT of torso and neck
30.6
9.4
12
*
WD305
NOMESCO Finland
Simple therapy of methastized malignancy with biomodifiers
+∞
9.4
9
*
9070/3-C62.1
ICD-O-3
Embryonal carcinoma, NOS, of descended testis
+∞
9.4
9
*
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
+∞
9.4
9
*
XW000
NOMESCO Finland
Bone marrow biopsy
6.1
9.1
24
41
TPH04
NOMESCO Finland
Cathetrisation of vein
2.1
8.9
105
546
TPX10
NOMESCO Finland
Implantation of vascular injection port
6.5
8.9
22
35
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
6.5
8.9
22
35
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
50.8
8.7
10
*
2395A
ICD-9 Finland
Neoplasm of unspecified nature, Other genito-urinary organs
50.8
8.7
10
*
N50.9
ICD-10 Finland
Disorder of male genital organs, unspecified
11.8
8.6
15
13
KBV02
NOMESCO Finland
Cystoscopic insertion of stent into ureter
6.9
8.4
20
30
N46
ICD-10 Finland
Male infertility
3.7
8.4
36
103
9063/3-C62.9
ICD-O-3
Spermatocytic seminoma of testis, NOS
+∞
8.3
8
*
8140/3-C20.9
ICD-O-3
Adenocarcinoma, NOS, of rectum, NOS
+∞
8.3
8
*
L02AE02
ATC
leuprorelin; implant, parenteral
+∞
8.3
8
*
L02BB03
ATC
bicalutamide; oral
+∞
8.3
8
*
N02AX02
ATC
tramadol; systemic, rectal
1.7
8.2
198
1332
7513
FHL
Test prosthesis installation
17.5
8.1
12
7
N50.8
ICD-10 Finland
Other specified disorders of male genital organs
7.9
7.9
17
22
ZXA05
NOMESCO Finland
Left side
1.9
7.6
111
631
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.1
7.5
84
427
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
3.8
7.5
30
82
C67.9
ICD-10 Finland
Malignant neoplasm: Bladder, unspecified
81.1
7.4
8
*
KA1FN
NOMESCO Finland
Isotope renography
13.6
7.4
12
9
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
3.2
7.3
36
116
YJ1AD
NOMESCO Finland
CT examination of abdomen for dose design of radiotherapy
+∞
7.3
7
*
C64.88
ICD-10 Finland
Other malignant neoplasm of kidney, except renal pelvis
+∞
7.3
7
*
JN4DG
NOMESCO Finland
Body very extensive MRI with high intensity magnet
+∞
7.3
7
*
JN4ED
NOMESCO Finland
Body CT examination with specail preparation
+∞
7.3
7
*
C83.39
ICD-10 Finland
Diffuse non-Hodgkin's large cell lymphoma UNS
+∞
7.3
7
*
C79.5
ICD-10 Finland
Secondary malignant neoplasm of bone and bone marrow
+∞
7.3
7
*
9071/3-C62.9
ICD-O-3
Yolk sac tumor, NOS, of testis, NOS
+∞
7.3
7
*
1860B
ICD-9 Finland
Malignant neoplasm of testis, Undescended testis[NEOP MAL TEST (ABD/ING),CA EMBR/TERATOCA/CHORIOCA]
+∞
7.3
7
*
KFB00
NOMESCO Finland
Biopsy of testis
16.0
7.2
11
7
M04AA01
ATC
allopurinol; systemic
2.3
7.2
69
328
J01MA12
ATC
levofloxacin; systemic
2.1
7.1
84
438
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
8.9
7.1
14
16
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
3.4
6.9
31
94
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.1
6.7
81
425
ZYY98
NOMESCO Finland
Missed treatment contact, no notification given by patient
22.8
6.7
9
*
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.5
6.6
50
212
PJD45
NOMESCO Finland
Excision of inguinal lymph nodes
70.6
6.4
7
*
KFD43
NOMESCO Finland
Unilateral vasectomy or ligature of vas deferens
70.6
6.4
7
*
JN2CG
NOMESCO Finland
Extensive MRI examination of lower part of abdoment with high intensity magnet
14.5
6.4
10
7
Y28
ICPC
Limited function/disability (Y)
9.4
6.3
12
13
C25.9
ICD-10 Finland
Malignant neoplasm: Pancreas, unspecified
+∞
6.3
6
*
KFC10
NOMESCO Finland
Bilateral orchiectomy
+∞
6.3
6
*
C67.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of bladder
+∞
6.3
6
*
XX9CD
NOMESCO Finland
Very extensive complementary CT
+∞
6.3
6
*
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
+∞
6.3
6
*
8120/3-C67.9
ICD-O-3
Transitional cell carcinoma, NOS, of bladder, NOS
+∞
6.3
6
*
KKB10
NOMESCO Finland
Excision of retroperitoneal tumour
+∞
6.3
6
*
C85.1
ICD-10 Finland
B-cell lymphoma, unspecified
+∞
6.3
6
*
KFC96
NOMESCO Finland
Other total excision of testis or epididymis
+∞
6.3
6
*
ZX080
NOMESCO Finland
Image guided radiotherapy
+∞
6.3
6
*
C77.9
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Lymph node, unspecified
+∞
6.3
6
*
PJ2AT
NOMESCO Finland
Biopsy of lymphnode with ultrasound guidance
27.0
6.2
8
*
R59.9
ICD-10 Finland
Enlarged lymph nodes, unspecified
10.2
6.0
11
11
AA1BD
NOMESCO Finland
Extensive CT of head and brain
5.6
6.0
16
29
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.0
6.0
79
427

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: C3_TESTIS_EXALLC – Malignant neoplasm of testis, excluding all cancers (controls excluding all cancers)

GWS hits: 3

This endpoint is excluded (different definition than used in FinnGen).