Seminoma of testis, excluding all cancers (controls excluding all cancers)

C3_TESTIS_SEMINOMA_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

only males

226837

2. Check conditions

None

226837

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C62.01&, C62.11&, C62.91&
  • Hospital discharge: ICD-9 186A
  • Cause of death: ICD-10 C62.01&, C62.11&, C62.91&
  • Cause of death: ICD-9 186A
  • Cancer registry: Topography ICD-O-3 C62
  • Cancer registry: Morphology ICD-O-3 9061
  • Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

362

4. Check minimum number of events

None

362

5. Include endpoints

None

362

6. Filter based on genotype QC (FinnGen only)

362

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12

Similar endpoints

List of similar endpoints to Seminoma of testis, excluding all cancers (controls excluding all cancers) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 362 - 362
Unadjusted period prevalence (%) 0.16 - 0.16
Median age at first event (years) 37.93 - 37.93

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
328
Matched controls
3280
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C62.11
ICD-10 Finland
Malignant tumor of the descending testicle, seminoma
+∞
309.6
246
*
KFC00
NOMESCO Finland
Unilateral orchiectomy
3434.6
271.0
224
*
9061/3-C62.9
ICD-O-3
Seminoma, NOS, of testis, NOS
+∞
264.9
217
*
D40.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Testis
560.8
200.3
180
7
JN4BD
NOMESCO Finland
Extensive body CT
30.6
99.3
137
75
130
Kela drug reimbursment
Malignant tumour
+∞
99.1
90
*
9061/3-C62.1
ICD-O-3
Seminoma, NOS, of descended testis
+∞
63.6
59
*
C62.10
ICD-10 Finland
Malignant tumor of the descending testicle, no histological verification
+∞
62.5
58
*
A03FA01
ATC
metoclopramide; systemic, rectal
16.0
62.2
107
96
KF8AE
NOMESCO Finland
Ultrasound examination of scrotum
25.7
61.9
88
46
JN4AD
NOMESCO Finland
Body CT examination
29.6
56.0
76
33
C62.1
ICD-10 Finland
Malignant neoplasm: Descended testis
+∞
49.2
46
*
KFH50
NOMESCO Finland
Insertion of prosthetic replacement for testis
+∞
44.8
42
*
C62.91
ICD-10 Finland
Malignant tumor in unspecified location in testis, seminoma
+∞
41.5
39
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
40.5
38
*
A04AA02
ATC
granisetron; systemic, transdermal
424.4
38.9
38
*
H02AB02
ATC
dexamethasone; systemic
50.6
37.0
44
10
C62.01
ICD-10 Finland
Malignant tumor of the non-descending testicle, seminoma
+∞
36.1
34
*
C62.12
ICD-10 Finland
Malignant tumor of the descending testicle, embryonic carsinoma, teratocarcinoma or coriocarsinoma
+∞
33.9
32
*
7511
FHL
Orchidectomy (unilateral), also includes funicularectomy
189.0
33.4
34
*
18699
ICD-8 Finland
Malignant neoplasm of testis
+∞
31.8
30
*
C62.19
ICD-10 Finland
Malignant tumor of the descending testicle, other or undetermined histology
+∞
31.8
30
*
JN3BD
NOMESCO Finland
Extensive abdominal CT
7.5
30.3
77
129
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.9
30.0
187
825
C62.99
ICD-10 Finland
Malignant tumor in unspecified location in testis,other or undetermined histology
+∞
29.6
28
*
C62.90
ICD-10 Finland
Malignant tumor in unspecified location in testis, no histological verification
+∞
29.6
28
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
4.2
28.8
138
479
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
+∞
26.4
25
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
25.3
24
*
L03AA02
ATC
filgrastim; parenteral
269.7
25.0
25
*
JN3AD
NOMESCO Finland
Abdominal CT examination
8.4
24.0
55
77
C62.00
ICD-10 Finland
Malignant tumor of the non-descending testicle, no histological verification
+∞
23.2
22
*
121
Kela drug reimbursment
Severe hypofunction of sexual glands
20.9
23.1
34
18
XZZ00
NOMESCO Finland
Active surveillance of a diagnosed cancer
+∞
22.1
21
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
18.9
18
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
17.9
17
*
1869A
ICD-9 Finland
Malignant neoplasm of testis, Other and unspecified testis[NEOPL MAL TESTIS (SCROTALIS),SEMINOMA]
+∞
17.9
17
*
A04AA01
ATC
ondansetron; systemic, rectal
20.0
17.6
26
14
WX408
NOMESCO Finland
General anesthesy, balanced
3.2
17.1
106
421
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
67.0
16.9
19
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
178.7
16.7
17
*
N02AA05
ATC
oxycodone; systemic
5.0
16.0
54
125
WF002
NOMESCO Finland
Radical radiotherapy
89.5
15.7
17
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
84.0
14.7
16
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
14.7
14
*
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
+∞
14.7
14
*
L01BC06
ATC
capecitabine; oral
+∞
13.6
13
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.7
13.6
63
197
D70.82
ICD-10 Finland
Drug-induced neutropenia
145.8
13.6
14
*
D29.2
ICD-10 Finland
Benign neoplasm: Testis
145.8
13.6
14
*
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
4.0
13.1
55
157
Z08.7
ICD-10 Finland
Follow-up examination after combined treatment for malignant neoplasm
+∞
12.6
12
*
C77.2
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Intra-abdominal lymph nodes
+∞
12.6
12
*
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
12.6
12
*
9085/3-C62.9
ICD-O-3
Mixed germ cell tumor of testis, NOS
+∞
12.6
12
*
ZXE00
NOMESCO Finland
One hour or less
2.5
12.3
126
656
E29.1
ICD-10 Finland
Testicular hypofunction
7.6
11.8
27
38
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
11.5
11
*
C62.9
ICD-10 Finland
Malignant neoplasm: Testis, unspecified
+∞
11.5
11
*
WZC30
NOMESCO Finland
Teaching
3.8
10.9
48
143
WX320
NOMESCO Finland
Spinalanesthesy
2.8
10.8
75
311
N02BE01
ATC
paracetamol; systemic, rectal
2.4
10.5
263
2048
L03AA13
ATC
pegfilgrastim; parenteral
+∞
10.5
10
*
C25.0
ICD-10 Finland
Malignant neoplasm: Head of pancreas
+∞
10.5
10
*
Y78
ICPC
Malign neopl male genital other
+∞
10.5
10
*
C62
ICD-10 Finland
Malignant neoplasm of testis
+∞
10.5
10
*
C62.92
ICD-10 Finland
Malignant tumor in unspecified location in testis, embryonic carsinoma, teratocarcinoma or coriocarsinoma
+∞
10.5
10
*
WW500
NOMESCO Finland
Blood transfusion
11.1
10.4
19
18
N46
ICD-10 Finland
Male infertility
6.2
10.2
27
47
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.8
9.7
42
123
JN4CD
NOMESCO Finland
Very extensive body CT
9.5
9.7
19
21
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
102.9
9.5
10
*
ZXE10
NOMESCO Finland
More than one and less than three hours
2.3
9.4
111
604
C62.0
ICD-10 Finland
Malignant neoplasm: Undescended testis
+∞
9.4
9
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
7.1
9.3
22
33
XX3DW
NOMESCO Finland
Time consuming IT work
5.2
8.7
26
53
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
6.7
8.6
21
33
ZX120
NOMESCO Finland
Intravenous
3.9
8.6
35
98
7513
FHL
Test prosthesis installation
92.3
8.5
9
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.7
8.4
61
256
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
+∞
8.4
8
*
WF004
NOMESCO Finland
Palliative radiotherapy
+∞
8.4
8
*
PJD53
NOMESCO Finland
Block dissection of aortic lymph nodes
+∞
8.4
8
*
2395A
ICD-9 Finland
Neoplasm of unspecified nature, Other genito-urinary organs
+∞
8.4
8
*
C62.02
ICD-10 Finland
Malignant tumor of the non-descending testicle, embryonic carsinoma, teratocarcinoma or coriocarsinoma
+∞
8.4
8
*
C20.91
ICD-10 Finland
Malignant tumor of the rectum invasive carcinoma
+∞
8.4
8
*
1869X
ICD-9 Finland
Malignant neoplasm of testis, Other and unspecified testis[NEOPL MAL TESTIS (SCROTALIS),EI HIST VAHV]
+∞
8.4
8
*
YL1BD
NOMESCO Finland
Extensive CT examination of pelvis for dose design of radiotherapy
+∞
8.4
8
*
JA1AE
NOMESCO Finland
Ultrasound examination of groin and abdominal wall
9.8
7.9
15
16
ZXD10
NOMESCO Finland
Scheduled procedure
2.1
7.8
109
629
YJ1AD
NOMESCO Finland
CT examination of abdomen for dose design of radiotherapy
81.9
7.4
8
*
JN4JR
NOMESCO Finland
Whole body extensive metabolic PET with CT
81.9
7.4
8
*
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
5.4
7.4
21
41
EP1AE
NOMESCO Finland
Neck ultrasound examination
6.0
7.3
19
33
C67.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of bladder
+∞
7.3
7
*
C67.9
ICD-10 Finland
Malignant neoplasm: Bladder, unspecified
+∞
7.3
7
*
C64.88
ICD-10 Finland
Other malignant neoplasm of kidney, except renal pelvis
+∞
7.3
7
*
WX402
NOMESCO Finland
General anaesthesia
2.7
7.3
52
216
KFA00
NOMESCO Finland
Exploration of testis
16.2
7.3
11
7
R50.9
ICD-10 Finland
Fever, unspecified
2.7
7.2
49
200
B01AB05
ATC
enoxaparin; parenteral
2.2
6.9
75
386
B01AB10
ATC
tinzaparin; parenteral
5.4
6.7
19
37
Z51.5
ICD-10 Finland
Palliative care
8.1
6.7
14
18
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.8
6.7
27
76
Z85.4
ICD-10 Finland
Personal history of malignant neoplasm of genital organs
+∞
6.3
6
*
C67.2
ICD-10 Finland
Malignant neoplasm: Lateral wall of bladder
+∞
6.3
6
*
C62.09
ICD-10 Finland
Malignant tumor of the non-descending testicle, other or undetermined histology
+∞
6.3
6
*
C25.9
ICD-10 Finland
Malignant neoplasm: Pancreas, unspecified
+∞
6.3
6
*
8120/3-C67.9
ICD-O-3
Transitional cell carcinoma, NOS, of bladder, NOS
+∞
6.3
6
*
E89.5
ICD-10 Finland
Postprocedural testicular hypofunction
+∞
6.3
6
*
Z08.0
ICD-10 Finland
Follow-up examination after surgery for malignant neoplasm
+∞
6.3
6
*
9063/3-C62.9
ICD-O-3
Spermatocytic seminoma of testis, NOS
+∞
6.3
6
*
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
6.2
6.1
15
25

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: C3_TESTIS_SEMINOMA_EXALLC – Seminoma of testis, excluding all cancers (controls excluding all cancers)

GWS hits: 2

This endpoint is excluded (different definition than used in FinnGen).