Malignant neoplasm of penis, excluding all cancers (controls excluding all cancers)

C3_PENIS_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

only males

226837

2. Check conditions

None

226837

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C60
  • Hospital discharge: ICD-9 187[1-4]
  • Hospital discharge: ICD-8 1870
  • Cause of death: ICD-10 C60
  • Cause of death: ICD-9 187[1-4]
  • Cause of death: ICD-8 1870
  • Cancer registry: Topography ICD-O-3 C60
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

217

4. Check minimum number of events

None

217

5. Include endpoints

None

217

6. Filter based on genotype QC (FinnGen only)

217

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12

Similar endpoints

List of similar endpoints to Malignant neoplasm of penis, excluding all cancers (controls excluding all cancers) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 217 - 217
Unadjusted period prevalence (%) 0.10 - 0.10
Median age at first event (years) 66.87 - 66.87

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
112
Matched controls
1120
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C60.1
ICD-10 Finland
Malignant neoplasm: Glans penis
+∞
94.6
77
*
C60.9
ICD-10 Finland
Malignant neoplasm: Penis, unspecified
+∞
57.3
50
*
PJA12
NOMESCO Finland
Sentinel node biopsy
+∞
52.2
46
*
8070/3-C60.9
ICD-O-3
Squamous cell carcinoma, NOS, of penis, NOS
+∞
51.0
45
*
KGC00
NOMESCO Finland
Partial amputation of penis
+∞
38.8
35
*
KGB00
NOMESCO Finland
Biopsy of penis
+∞
38.8
35
*
8070/3-C60.1
ICD-O-3
Squamous cell carcinoma, NOS, of glans penis
+∞
37.6
34
*
C60.0
ICD-10 Finland
Malignant neoplasm: Prepuce
+∞
35.3
32
*
D40.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other male genital organs
+∞
34.1
31
*
JA1AE
NOMESCO Finland
Ultrasound examination of groin and abdominal wall
87.0
33.5
36
6
PJD55
NOMESCO Finland
Block dissection of inguinal lymph nodes
+∞
30.6
28
*
JN4BD
NOMESCO Finland
Extensive body CT
27.6
25.5
35
18
KGD00
NOMESCO Finland
Partial excision of glans penis
+∞
23.8
22
*
KGD05
NOMESCO Finland
Partial excision of body of penis
+∞
22.7
21
*
130
Kela drug reimbursment
Malignant tumour
+∞
21.5
20
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
+∞
21.5
20
*
KGH10
NOMESCO Finland
Operation for phimosis
18.9
21.3
33
24
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
20.4
19
*
PJ5AQ
NOMESCO Finland
Sentinell lymphnode SPECT with low dose CT
+∞
19.3
18
*
N48.1
ICD-10 Finland
Balanoposthitis
17.3
18.2
29
22
C60.2
ICD-10 Finland
Malignant neoplasm: Body of penis
+∞
18.2
17
*
H02AB02
ATC
dexamethasone; systemic
99.2
16.0
17
*
KGD96
NOMESCO Finland
Other partial excision of penis
+∞
16.0
15
*
N47
ICD-10 Finland
Redundant prepuce, phimosis and paraphimosis
12.6
15.9
29
30
JN4AD
NOMESCO Finland
Body CT examination
22.4
15.4
22
12
C60.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of penis
+∞
14.9
14
*
JN2AE
NOMESCO Finland
Ultrasound examination of lower part of abdomen without contrast
61.5
14.2
16
*
C77.4
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Inguinal and lower limb lymph nodes
+∞
13.8
13
*
WF002
NOMESCO Finland
Radical radiotherapy
+∞
13.8
13
*
116
Kela drug reimbursment
Prostate cancer
+∞
13.8
13
*
ZXE10
NOMESCO Finland
More than one and less than three hours
4.8
13.5
63
238
TKD00
NOMESCO Finland
Dilatation of urethra
145.5
12.7
13
*
WX402
NOMESCO Finland
General anaesthesia
6.4
12.6
36
77
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
5.7
12.2
39
96
WX408
NOMESCO Finland
General anesthesy, balanced
4.8
11.7
46
141
XKD00
NOMESCO Finland
Uroflowmetry
4.8
11.5
45
137
UKC02
NOMESCO Finland
Cystoscopy
4.8
11.4
44
132
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
9.7
11.3
23
29
WZC30
NOMESCO Finland
Teaching
7.9
11.2
26
41
YL1BD
NOMESCO Finland
Extensive CT examination of pelvis for dose design of radiotherapy
+∞
10.6
10
*
PJD45
NOMESCO Finland
Excision of inguinal lymph nodes
+∞
10.6
10
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
4.2
9.7
43
145
PJD54
NOMESCO Finland
Block dissection of iliac lymph nodes
+∞
9.5
9
*
KGC10
NOMESCO Finland
Total amputation of penis
+∞
9.5
9
*
L02AE02
ATC
leuprorelin; implant, parenteral
+∞
9.5
9
*
KGD10
NOMESCO Finland
Destruction of lesion of penis
+∞
9.5
9
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
9.5
9
*
ZZA00
NOMESCO Finland
Split skin graft
15.8
9.0
14
10
Z51.5
ICD-10 Finland
Palliative care
15.8
9.0
14
10
KDH10
NOMESCO Finland
Meatoplasty of urethra
54.3
8.8
10
*
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
6.1
8.7
24
48
L90.0
ICD-10 Finland
Lichen sclerosus et atrophicus
97.0
8.5
9
*
WX240
NOMESCO Finland
Penis blockade
97.0
8.5
9
*
JN3BD
NOMESCO Finland
Extensive abdominal CT
5.7
8.5
25
54
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
+∞
8.4
8
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
8.4
8
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
8.4
8
*
TKC20
NOMESCO Finland
Catheterisation of bladder
6.4
8.0
21
39
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
16.6
7.9
12
8
ZXE20
NOMESCO Finland
More than three and less than five hours
4.5
7.9
29
80
R74.8
ICD-10 Finland
Abnormal levels of other serum enzymes
10.0
7.8
15
17
R33
ICD-10 Finland
Retention of urine
5.1
7.8
25
60
D07.4
ICD-10 Finland
Carcinoma in situ: Penis
85.4
7.5
8
*
N48.8
ICD-10 Finland
Other specified disorders of penis
85.4
7.5
8
*
JN4CD
NOMESCO Finland
Very extensive body CT
17.2
7.4
11
7
8051/3-C60.9
ICD-O-3
Verrucous carcinoma, NOS, of penis, NOS
+∞
7.4
7
*
D29.0
ICD-10 Finland
Benign neoplasm: Penis
+∞
7.4
7
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
7.4
7
*
PJ5AN
NOMESCO Finland
Localisation of sentinell lymphnode with isotope imaging
+∞
7.4
7
*
A04AA02
ATC
granisetron; systemic, transdermal
+∞
7.4
7
*
JN2BG
NOMESCO Finland
MRI examination of lower part of abdoment with high intensity magnet
+∞
7.4
7
*
L02BB03
ATC
bicalutamide; oral
+∞
7.4
7
*
WX320
NOMESCO Finland
Spinalanesthesy
3.5
7.1
37
137
A03FA01
ATC
metoclopramide; systemic, rectal
5.7
7.1
20
41
J01DB01
ATC
cefalexin; oral
3.5
6.5
95
689
TKC10
NOMESCO Finland
Percutaneous puncture of bladder
19.3
6.4
9
5
Y04
ICPC
Penis symptom/complaint other
28.4
6.3
8
*
A04AD12
ATC
aprepitant; systemic
+∞
6.3
6
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
6.3
6
*
8070/3-C60.0
ICD-O-3
Squamous cell carcinoma, NOS, of prepuce
+∞
6.3
6
*
N35.9
ICD-10 Finland
Urethral stricture, unspecified
13.5
6.2
10
8

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: C3_PENIS_EXALLC – Malignant neoplasm of penis, excluding all cancers (controls excluding all cancers)

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).